Document 7vgg9j9Vm0Z7nbpZkOYDQDdR

AR226-2853 Material ted Copies to: E I. du Font de Nemours and Company Haskell Labi .atory for Toxicology and Industrial Medicine HASKELL LABORATORY REPORT NO. 960-76 MR Haskell No. T5752-- Other Codes Sample Ready for Testing 9- 28-76 "Submittea by Organic Chemicals ^epartment^Jackson Laboratory .a \s I Jis ACUTE ORAL TEST Procedure: The test material, as an aqheous solution, was administered by intragastrie intubation to young adult ChR-CD male rats in single doses, ;one animal per dose level. Survivors were sacrificed 14 days later. V/ h i Results : Dose (mg/kg) 25,000* 17,000 11,000 7,282 4,713 3,219 2,250 2,141 1,401 670 Solution <%) 90 70 70 30 30 30 10 30 30 10 Mortality** D 2 d. S 14 d. S 14 d. S n. 14 d. S 14 d. S 14 d. S 14 d. S 14 d. S 14 d. S 14 d. _Clinical Signs Lethal Dose: Drowsiness on day of dosing, and lethargy and weight loss on the day after dos ing. ' Sublethal Doses: Weight loss for 1-3 days aTtlr dosing at 4,713 mg/kg and above. ? ALO 25,000 mg/kg S u m m a r y -a-s- v-- eryj l--ow- toxicit^ when oavdumiiunui,s>t.ecriecdu uoir.aalul;y tlou y;uoung adult ChR-CD male rats in single doses; its oproximate LTeefthhaall Dnonsae. (fAALTD.)m iso 25,0n0o0n mg/kg ofc body weight. ** D - ( > d. = Found dead f ) days after dosing, S - ( ) d. Sacrificed ( ) days after dosing. CVFidhg Date Issued: December 17, 1976 Report by: Approved by: cihhaarrles V. Crazier Research Toxico . lichae1 Kdpln Chief, Oral Toxicology Section * Si ! Company Sanitized. Does not contain TSC CB1