Document 7R61jawqRm3L9BBvpy7R5dRN8

omscare: + RAY UNAIK EDUNAIKAINED UNAIKED UNAIKAINED UNAIKED i}AMLEO AMLEO 2016 AO2a 2, ao - fich is SA eer ite gt RECEIVED RECEIVED wnt 31377 543- FYI Class Coulette AbstraOct Abstract rganically synthesized lysinoalanine was fed to weanling rats at animalsKaryomegalic levels of 0 0.025 0.05 0.1 and 0.5 in a purified diet alterations were observed in the renal tubular cells of all fed the lysinoalanine diets for 4 wk and the high lose level also caused tubular necrosis Renal lesions were observed alco after oral or.ip administration of 30 mg lysinbalanine for 7 days and consisted of dilatation of proximal rT tubules necrosis of epithelial cells and karyomegalia limited almost analogous oe exclusively to the outer medullary stripe The administration of relatively small quantities of lysinoalanine produced lesions to those seen in rats fed treated proteins for much longer periods of time DIETARY e EFFECT OF VARIOUS COMPONENTS ON ABSORPTION AND TISSUE DISTRIBUTION OF ORALLY ADMINISTERED INORGANIC TIN IN RATS P. Fritsch G. de Saint Blanquat and R. Derache Groupe de Recherches sur la Toxicologie des Aliments et des Boissons INSERM U 87 Universit^'Paul Sabatier Institut de Physiologie 2 rue Fran^ois Fran^ois Magendie 31400 - Toulouse France Received 12 February 1976 Abstract absorption of tin from the intestinal tract and its distribution in the tissues was studied in groups of rats given labelled stannous chloride by gastric intubation in conjunction with various other food namely given components sucrose sacorbic acid potassium nitrate ethanol as a 20 solution a solution of albumin and an emulsion of sunflower oil . and % Tween 20. Each of these was given alone with the tin salt and an additional group of rats was given the first three and the tin salt all together In all groups 90-99 of the administered adioactivity was excreted in the faeces within 48 hr at which time fuecal excretion and retention in the alimentary tract accounted for 38.7-99.9 of the dose Only traces of 113Sn were detected in the wide range of organs and tissues eGxaalmtined irrespective of the other food components administered with the tin -- ee TNHALATION OF TALC BABY POWDER BY HAYSTHRS TNHALATION meme A.P. Wehner G.M. Zwicker and W.C. Cannon Biology Department Battello C.R. Watson Systems Department Battelle Pacific Northwest Laboratories Richland WA 99352 and , W.W. Carlton Department of Microbiology and Pathology School of Veterinary Science and Medicine Purdue University West Lafayette IN 47907 USA Received 25 September 1976 Abstract of 50 male and 50 female Syrian golden hamsters were exposed to talc aerosol for 3 30 or 150 day 5 days for 30 days or for 30 or 150 day either until they died naturally or for a maximum of 300 days The mean concentration of the respirable aerosol fraction was approximately 3 litre and the mass mean aerodynamic diameter was 6 m Following the - = 544-- exposures the animals were observed for the remainder of their life span At death lungs trachea larynx liver one kidney stomach uterus one ovary or one testis and all tissues showing gross lesions were collected for histopathological examination Deposition of tale particles in the lungs of the exposed anicals was demonstrated by ray fluorescence and by ray diffraction The exposures to talc aerosol had no effect on body weight survival or the type incidence or degree of histopathological change in the exposed groups compared with exposed controls ~~ EVALUATION OF THE CORNEAL IRRITANCY OF TEST SHAMPOOS AND DETERGENTS IN VARIOUS ANIMAL SPECIES L.L. Gershbein Neurophysiological Laboratories of Northwest Institute for Medical Research 5656 West Addison Street Chicago Illinois 60634 and J.E. McDonald Department of Ophthalmology Loyola University Stritch School of Medicine Maywood Illinois 60153 USA Received 4 September 1976 Abstract commercial shampoos two cationic detergents 2 Roccal and % Isothan 15 a nonionic agent 20 Neutronyx 600 and a 1 v mixture of the last two products were instilled into the eyes of several animal species and the corneal changes were followed To evaluate corneal change the area intensity and vascularity of the opacity were rated and scored In a few instances the eyes were rinsed with water after the test agent had been in contact with the comea for a short period in these . cases the initial contact of the agent with the cornea was shown to be critical Corneal sensitivity was highest in the rabbit hamster and mouse intermediate in the rat and guinea and possibly lowest in the dog cat rhesus monkey and chicken SERUM ALKALINE PHOSPHATASE AND MICROSOMAL ENZYMES IN THE HEAGLE DOG R.T. Keefe P.M. Newberne and T. Myers Department of Nutrition and Food Science Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Received 16 February 1976 Abstract association between increased serum alkaline phosphatase activity and increased hepatic microsomal activity in the beagle has been investigated Low doses of a combination of ethanol 633 day propylene glycol 672 day and chloroform 30 day raised alkaline phosphatase activities in both serum and liver without concurrently increasing three microsomal enzymes aminopyrine demethylase nitroanisole demethylase and benzo pyrene hydroxylase Studies with enzyme inhibitors suggested that the increases in hepatic and serum phosphatase levels were predominantly due to enzyme of the hepatic type ' . . Tee SahS.s Vo me e athe tae aev + ... des &: JNJ 000250554