Document 7R58ZmQXkgq4pBKpjLxmoKQro

FILE NAME: Oil Industry and American Petroleum Institute (API) DATE: 1949 Feb 1 DOC#: API023 DOCUMENT DESCRIPTION: Minutes of the Subcommittee on Carcinogenicity with Attachments i January *, 19*9 He. Bebfft A. U m Battering Laboratory of Applied Physiology Collage of Medicine niTwreity of Ciaclimoti Claclati 19, oblo Soar Doetor Kahoe: I a t rani inliwl of the proylsloaa n t forth la the lottar of agreement datad Jam 15, 19*8, thereby a fiaart to jay the Jhdnareltr of Ciaolamtl a haTanna of $25,000 on January 1, 19*9 ad tha Unisareity agraad to retara any W1--** rwmnTnd la tha fand on Jam 30, 19*9 I t la ay m teretaadlag th at olmmmtairina beyond the oanfcrol of tha Oainmrsity have delayed tha nark planned for the period andlag Jam 3 0 , 19*9 and th at I t may ha poealhle th at tha *65,000 remitted hgr la tta r datad Ja l? 6, 19*8 ay ha an ffician t to coros* a ll azpaodltaras for tha period. XT th is la trae 70a m j foal I t o l i i ha niaamaearj for no to oeod job tha $25,000 nhloh la non due and payable. A atata-- it af f a r nlahaa la tha s e tte r v i li ha appreciated. *ary tm ly poors, UTS:d oc : Mr. Lacey Valter Or. Mainar body API 04822 *- Standard Oil Developm ent Company R esea rch and D evelopm ent Departm ent 15 w e s t 51s t s t r e e t , New Y o rk 19, n . y . u p-ISCHF.R MANAOKH January 7, 1949 jir D. V. Stroop American Petroleum Institute 50 West 50th Street He York City pear Mr. Stroop: You will recall that among the recommendations adopted at the meeting of the A.P.I. Medical Advisory Committee Sub-Comm it tee on Carcinogenicity on November 11, 1948, at Chicago, Item 4 (appear ing in the minutes) reads as follows: "That the fundamental chemical and physical studies that are indicated to investigate the operational technical aspects of this problem may require considerably more money than anticipated; and it is recommended that the technical advisers group consider the problem again and present their recommendations to the Sub committee on Carcinogenicity." In this connection, Hr. Mclver Woody, Chairman of the Sub committee on Carcinogenicity, has written me as follows: "Now that Dr. A. Wesley Horton has been selected by Dr. Kehoe to investigate the chemical aspects of the problem, it will be greatly appreciated if you would oall a meeting of the technical advisers to confer with Dr. Horton on methods of selecting samples for future testing, taking into account the nature of the crude, its source, the temperature conditions, etc." As I understand the situation, it is desired that the tech nical advisers redefine the objectives of the program to be coordlnated by Dr. Horton and aid him with the selection of suitable samples for study by the Kettering laboratory of Applied Physiology, University of Cincinnati, College of Medicine, under the direction of Dr. R. A. Kehoe. Y V Itr.D.V.S. I -2 1/7/49 I shall be glad to conduct this meeting In response to Dr. W oody's Invitation and would suggest the date of January 31, 1949, In the A.P.I. Board Room on the 20th floor at 89 fluihefeliBi fj.arff', New York City, at 10:00 A.M. Since the group will wish to arrive at definite conclu sions and recommendations, it is hoped that the technical advisers will find it convenient to attend this meeting in person. If you are in agreement with this method of putting into effect the recommendation adopted by the Medical Advisory Com mittee, I shall appreciate your extending an invitation to Dr. Horton and the associate members of the Medical Advisory Committee to attend this meeting and to others who you feel would be in terested in participating in the discussion. Please advise. Very truly yours, HGMFHC CC:Dr.Mei.Woody Dr.J.P.Holt API 04824 \ M ORATORY OF APPLIED PHYSIOLOGY - , OF MEDICINE-- EDEN AVENUE UNIVERSITY OF CINCINNATI CINCINNATI 19. OHIO J anuary 12, 1949 (via air mail) CABLE ADDRESS: KETLAB. CINCINNATI TELEPHONE: UNIVERSITY 2665 Mr. D. V. Stroop, American Petroleum Institute, 50 West 5Cth Street, N e w York 20, N e w York. Dear Mr. Stroop: In reply to your letter of Jan u a r y 10th, I shall plan to attend the m e e t i n g of the Sub-Committee on Carcinogenicity on Monday, January 31st. Very truly yours, AWH:fe A. W e s l e y H o r t o n API 04825 ' \ I Esso Standard Oil Company M edical Departm ent E s s o B u ild in g . 15 W e s t 51s t s t r e e t , N ew Y o rk 19. N. Y . W OODY. M. D. * C! , 1 * 0 1 0 * 1. D 1. K T O . . s DENHOLM . M. D M B O I C A L DI I S E C T O R p slM. M . D. "Si.H O B P B Y H I C I A J P LEONE, m . d . CIAN A L B E R T C. ORUNOW , M. D. C L IN IC IA N C L Y D E M. B E R R Y . PH . D. IN D U ST R IA L BYO lK N IM T January 12, 19^+9 t Hr. D.V. Stroop American Petroleum Institute 50 Vest 50th Street Hew York 20, S.Y. > a r Mr. StroopS A special meeting of the Subcommittee on Carcinogenicity will te held in Room 1000, 15 Vest 51st Street, Rev York City, at 9 0 0 A.M. on Tuesday, February 1st, 19^9 . I hope you can arrange to be preeent, especially as both Mr. E.O.M. Fischer and Dr. A. Wesley Horton may have something interesting to tell us. II McIVsEH Very truly yours, API 04826 4 U N IV ERSITY O F CINCINNATI CO LLEG E O F M EDICIN E C IN CIN N A TI 1 0 , OHIO l a b o r a t o r y o f a pplic o p h y s io l o c y January 12, 1949 Mr. D. 7. S t r o o p , The American Petroleum 5G W e s t jjth S t r e e t , N e v Y o r k City 2^. Institute, C A B L I AD O REIS i K IT LA B. CINCINNATI TCLIPHON Cs UNIVERSITY 2 6 B Dear Mr. Stroop: T h a n k s very m u c h f o r y our* l e t t e r of J a n u a r y 4 to v h i c h I a m g l a d to reply. I have checked up on our expenditures up to the present time, and I have considered carefully our probable expenditures during the first half of the year 1949. It seems quite clear to me that ve shall not be able to carry out the e x t e n s i v e v o r k t h a t v o u l d b e d e s i r a b l e b e t w e e n n o w a n d J u n e *0, 1949. We shall do the best ve can, but even so it seems quite clear to m e that the fun d s n o w in our hands will support; our vork a d e q u a t e l y u n t i l J u l y 1. T h e r e is n o n e c e s s i t y , there f o r e , for your sending us the additional $ 25uu. at this time. I a n t i c i p a t e that v e s h a l l b e a b l e to get o u r w o r k v e i l u n d e r v a y before July 1, and certainly the sums previously agreed upon will be r e q u i r e d to c o n d u c t the w o r k p r o p e r l y a f t e r J u l y 1. With kindest personal regards, Cordially yours Dob er t A. Kehoe, M* D- C .C .: M r . L a c e y W a l k e r Dr. Mclver Woody API 04827 1 ! iammrj 20, 19*9 Mr. Jcha S. Soma Standard Oil Co. (law Jereey) 30 EocJoefeUar Plant Hov lark 20, 1.1. Soar Mr. ftiaoin; For joor fllo Z an returning herevlth the .nmrnrandng (l-13-*9) ft-- Doctor Pa*, vhich jm handed to In Washington on Jtaaary 13th. It now devalopa that five a-- hera of the API Nodical Adrlearj Ccanlttee bar been larited to attend the National Cancer Conference In Neaphla, February 25-27, 19*9- All, or aoet, af theee nanbara vili attead a nettiTig af th API Sdbec-- lttee on Carclnogemlclty to he held on Fahraary lat. At that tino th adbjeet of Doctor Pae'a -- oramina vili he dlesaeeed to a conciasion vhich vili he tra7-- 1ttod te jnoa. Tory truly jaura, BTS:4 Xaeloeure ce: Mr. VUllan B. loyd, *. API 04828 4 m ; -1 '; ! ` . ' 4 1A3A9 It tea not ten brought to ny ottostioa that tte Chalrnan of tte Medleal Adrlaory OToep of API tea boon aated to participate la tte AMarlen Cneer Soelety Mooting In afeloh tte federal Owrowont vlll loo tote port. It oo teppena ttet Jane? tea already ten trootfrt lato tte platore. Tte Aaorlen Conner Society grogp bare loomed tkroegfc eon oteanol ttet Jetreay tea ten taking n oca rotter extenoire roooarok n tte beery catalytic eyele goo probln. Jm ftet, Sr. Molt tea already teen aated to participate In tte forthogoing Aaorlooa Conoer Society eating. loowNIjig to inpilteinta ttet m k*ra node, It aeon oat probable ttetbeeill bore to participate. Slnoe It la jroteblettet tte tearlen API any te noted to note a atotwnt to tteTpreeo relative to tte nonpar jorobim on related te tte potroleno Indnakry^ tkla aattar la being broogtt te peer attootln nor. Hr. Streep vlU nndaobtedly giro joo all otter pertinaet detalla. - t: A Sr. Sotert e. Page (0 0 11 ) API 04829 * 4* S ta n d a r d O il C o m pa n y (indiana) , .PAMS 'T. DIB"'0" O F R E S E A R C H R esearch Department W hiting R esearch L aboratory P. O. B o x 431, W h it in g , I n d ia n a January 26, 19U9 API Medical Advisory Committee Mr. D. V. Stroop i( American Petroleum Institute 50 West 50th Street New York 20, New York Dear Sirs Replying to your letter of January 10, I regret to advise it will be impossible for me to attend the meeting scheduled for Monday, January 51> 1?U9. ' Very truly yours, E. W. ALALE EIA/lsg cc H.G.M. Fischer . P.S. I am greatly interested in the decisions and recommend ations which will be made in this meeting and trust that you will send me a copy of the minutes. E.W.A. API 04830  Mnmras SUBCOMMITTEE 05 CABCIBOQZFICnT Tebruarv 1. 1W) .meeting of the Subcommittee on Carcinogenicity was conrened at 10 A.M., Tuesday, fetoruary l*t, 19^9. at 15 West 51st Street, Sew lark City. jjp/gTBS FBKSXBT: T.M. Trank A.*. Hoag J.P. Holt T.J. Kelly W.B. Levis M.1T. levquist CJL. Swan Hclver Woody A.X. Dooley H.O.H. Tischer H.F. Lankelma K.O. KacKensie H.H. Warrick S.B. Wilson (representing H.H. Zuideaa) TISlTCESj. B.C. Cole ffESTS: A.W, Horton - University of Cincinnati D.7. Stroop - American Petroleum Institute TOTAL IS ATTEHDASCS - 17 MBtHKRS ABSEST L.E. Curtis L.C. Beard B.S. Bonelb A.J. Koewisg, Jr. t Hr. Tischer, reporting on the January 3lst meeting of the technical advisors of the t Subcommittee presented the following objectives for discussion! 1 - Xstabllsh in what crudes and fractions thereof, compounds are present that Bay have carcinogenic properties and the types of processes that may either concentrate or create them and, if so, under what conditions. 2 - Xstabllsh analytical procedures to permit distinguishing between fractions that according to biological testing possess carcinogenic properties and those that do not. It would be helpful if a carcinogenic index could be devised for a refiner API 04831 s 9 to evaluate the degree of carcinogenicity of materials and products greed that the following processes and materials should he studied: It **8 OfRAlflHT TgETtlUL PPOCTRRTjj!; Qas oil cracking Viscosity breaking of residues Haphtha reforming Coking das reversion Steam cracking mfALYTIC PROCESSES: Houdry TCC FCC Eoudryflow Cycloversion Hydroforraing Desulfurization (marginal case) SPECIFIC PRODUCTS: Sod waxes . Slack waxes Certain raw lube stocks (untreated) Solvent extracts (furfural, phenol, aulfurdioxide) icid oils from acid sludge (marginal case) PRODUCTS ISOM OTHER ITOUSTRIES: Coal tar Vater gas tar Shale oil - domestic and British sources. tossy will make available to Dr. Horton all its available data and information tod It is to be hoped that other oompanies will do the same. Sr. Horton reviewed the Kettering laboratory report which was distributed to the msbers last lovember, pointing out that the findings contained in the body of the nport are baaed on histological study of tissue sections, as well as on gross observations, while the graph, which was prepared earlier, is based on gross observations only. He was requested to prepare a summary of the report, including o revised graph showing cancers as determined by histological examinations and the pads of malignancy. ' &r. Horton then reported on the status of the building program at Kettering laboratory, saying that adequate space for the chemical laboratory should be avail able by April 1st; the "<1 rooms should be ready for use about June 1st. Holt described the meeting to be held in Memphis February 2hth to 27th under jbe sponsorship of the American Cancer Society and the Xational Cancer Institute wtPBsJj at which Dr. Hoag, Dr. levquist, Dr. Woody, Mr. Fischer and he will be I**bers of the panel on environmental cancer. Hecorders will take down all that aid in the panel discussions, have it mimeographed for use of the participants -2- API 04832  t ft next session; and the moderator of each panel will present a summary at the * oeral meeting at the close of the conference. The proceedings of the meeting ^ll be published in the Society's magazine and other journals. pr. Hoag was glad that the petroleum industry is being represented so that in durate statements may he corrected. Ee cited as an example the tendency of ^informed persons to say that refined paraffin wax produced cancer. Ee felt the various companies should try to get the facts to the employees and said he is preparing an article for Socony's employee magazine titled "Some Things You Should Enow About Cancer", and including some discussion of skin cancer. Kf, Cole was of the opinion that all these recent developments were forcing the etroleum industry to take action. Ee suggested that all iPX companies should institute the indicated control steps soon. Dr. Kelly reported that a bulletin "Environmental Cancer" has been published by the Bational Cancer Institute and is available from the Superintendent of Documents, Washington, D.C. at a price of twenty cents. pr, Drank reported that local management was supporting his medical program and that more Information (possibly including pictures) from the API would be helpful la informing management more thoroughly of the problem. pr. Swan stressed the importance of any publicity or information being accurate -J and complete. Dr. Levis said that in the matter of giving out information it was essential to b factual and to create the opportunity for its release. Nr. Stroop believed that the publicity problem was not so disturbing; that the API had a good defense against possible misstatements because of the investigations now in progress by the AFX and the individual companies. Dr. MacKenzie said that with the Cancer Society now. in the picture, added weigit vould be given to the problem. Ee cited reports on incidence of skin cancer among I various groups and recommended that in all information releases, the complete story be given to show that there are other things than certain petroleum products i tAlch may cause skin cancer. Dr. Bewquist recommended that the statement now on file with the APX be reviewed and trought up to date if necessary. Dr. Holt pointed out that in his opinion, and it was the view of the Jersey Company, that the employees should be told that a potential hazard exists relative to the handling of high boiling oils, and that reasonable precautionary measures should be instituted to prevent akin contact and ingestion of these materials. These views and suggestions are based on the biological and experimental results which have shown that these materials cause the development of cancer when applied repeatedly to the skin of mice and other animals. Dr. Hoag S a i d that Socony has started an educational program by first informing local plant doctors who, in turn,are gradually telling foremen groups and the employees about cancer, including skin cancer. He said that the men have been "3" API 04833 5> 0 to the medical department when they notice warts or other skin lesions. _r< Savquiet vas of the opinion that it would he inadvisable to single out the skin cancer and that it would he better to tie it in with other conditions, igv examination directed toward skin cancer should he tied in with the periodic 0garninat ions. Kf, Tischer pointed out that with precautionary measures in effect, such as tagging lines and tanks, provision of showers, emphasis on personal hygiene, the men will Ik shy* they are told merely that the materials are irritants, they may be- c0ne careless and not follow the precautions. gr. Tischer, in response to a request for information, said that, while not all fractions boiling above 700 T. were carcinogenic, they should be considered as suspicious until proven otherwise. Wanes were in a class by themselves. The normally crystalline carcinogens in crudes (e.g. Lima crude) may be concentrated during certain steps in wax processing. The 700 7. cut-point applied only to hydrocarbons; other carcinogenic compounds that boil below 700 7. may be present, such as aromatic amines perhaps in shade oils, certain sulfur and oxygenated cob*. pounds. Dr. Eolt, in discussing the effect of dilution, sadd tests show that 65-69^ nixtures of decanted oil in non-carcinogenic oil have essentially the same potency &s undiluted decanted oil, $0$ mixtures about 3/4 the original potency, 29$ aixtures 1/3 to 1/4 of the original potency. Ho data are avadlable as yet on the potencies of blends containing less than 25$ decanted oils. gr. Tischer, in reply to an inquiry about crank-case drainings, said that he had no information as to their carcinogenicity but would suspect them because of the severe conditions that crank-case oils may undergo. Dr. Trank said he had seen a statement that pipeline paint may be carcinogenic. It was decided to hold another meeting of the Subcommittee after the Memphis seating and before the Detroit meeting, the time and place to be determined by the Chairman. 4.1. Dooley Secretary Mclver Woody Chairman API 04834 5 * U N IV E R S IT Y O F CINCINNATI C O LLEG E O r M EDICIN E CIN CIN N A TI 1 9 , OH IO I ta, ULk**on*TORy o r a f f l ib o p h y s io l o g y _ -,, _ . reoruary r2-dO , - - - CAB LB ADDKBSSi KBTLAB. CINCINNATI TCLEFHONBi U N m u ir r 2 6B Mr. D* V. S c r o o p , American Petroleum =0 W e s t 5 0 t h S t r e e t , ;ev Y o r k C i t y 20. Institute, pear Mr. Stroop: I am sending you herewith an account of the financial status of the American P e t r o l e u m Institute project for the i nvestigation of petroleum c ompounds as of J a n u a r y 1, 19^9- Very truly yours, ef Enc. E. R. Fortlagef, Sec r e t a r y to Dr. Kehoe API 04835 ^ * UNIVERSITY OP CINCINNATI KETTERING LABORATORY OF APPLIED PHYSIOLOGY ACCOUNT -OP TEE AMERICAN PETROLEUM INSTITUTE For the Fourth Quarter of 1948 (Based on Proportion of Time Actually Spent on Project) ' Robert A. K e h o e - S u pervision Francis Heyroth - Chemical and Toxicological Asst. Karl Kitzmiller - Pathological Assistance Wesley Horton - Chemical Assistance Sylvan Witherup - fl R j. F. T r e o n - If If Dan Duvall Tom Gahegan Ruth Tlger - Technical Assistance - n n - N R I 34.60 41.57 138.40 420.00 60.00 31.11 44.44 16.28 _____ 789.92 prr,T.ANECUS E X P E N S E Traveling Expense - November and December Chicago to Cinti. (Dr. Wesley Horton) 1J. 6 1 Cinti, to Chicago 108.03 Philadelphia to H.Y. " " 22.37 Cinti, to Chicago (Dr. R. A. Keboe ) 52.50 Cinti, to Chicago (Dr. F. F. Heyroth) 4 1 . 8 8 Proportion of Secretarial, Library, Janitors, Wash Boys, Draftsman, Shipping Clerks, Animal Caretakers, Hl8topathological Preparation ............. . . . . 242.39, / 238.55 Proportion of Heat, Gas, Electricity, Steam, Telephone, ' Maintenance, Pensions, Annuities etc d ........... 393.00 1663.86 Balance Remaining for Work in 1948 at end of Third Quarter 1948 ............. $24,261.84 Expendtures 4th Quarter 1948 ............. 1,663.86 Balance Remaining for Work In 1949 . . . . 22,597*98 API 04836 D v s 4^ . ^'\ - f - J /^ A w a .U.-, J * * ------ i# 19*3 dp. je. V. C. A. 0. LaLBoie, tenfce E . J r i . . , DPuwPDonBtyl&ra*&BlAe iU lt reu JlB&ufActurlag and Coapany Co. j r . D . A In r i , AlaBfTwa Ccnpany of AaarloA l f . & asll to ra flo ld , Rapaolds Jtetala Ccacsuqr . 1. J * U C B f 9 n l V 4 n * l O l l r pOAuotf CflHpao? pr* . "&tiftejr* asrlo aa PotrolaaB Znatitut IriMT O B AOOOtmt Cff 411 flaerld farth , er iUaltod oc t .X 1b ___ A ll B40lp ht 0ff t0 3h AooGrda&oe lth y bM t adgnaat BtvibBUm af thrAnr-------* ontlnuad foy a Boocid ffB l i A9*8. ThU 4 B4d of th libyary v lth n t t Ite o r^ U 4 latMUM iB . tk i N t ln t id 1B 19*6} PoparoMtod .AtriM f m v *m m ` All kSjaA* I t r a t v th tituto {vfcie& das to the ob to b* pfovld th rvioM i M n t a l srfe# x *5 A l s o immttcLim (ovmr that lneowas ln th rat of tq>pli4 af aparcwal# hut th 4 pyMflj 4*6ld4d ml A a g a h l y ln UteSAtUM 4 M >th ogpertBBBta! tu w k tamm m t m u t&an th fw d U l tf Diotatod bat not M d * ttte. r^ c i s g r x -i a g g ; "! : g . r API 04837 1 i .piatta Company of imertea Sbar of Ispesso as ItoAlsod b a i a m o Remolala from 1947 Appropri*tion - 1000.00 Roeolpts 1940 ...................... 3000.00 pffiemn PUdo urn Zaetltuto Sfcm of Xxpoaao as Itamliad Baiane from 1947 Appropriation........... 9300.00 RoeelpU 1 9 4 8 .......................... 9300.00 Balance for 1949 Appropriation.................. 2. durant da famours bara of Xxpoaao as Itorn!tod Roeolpta 1948 . . . . . . . . 4000.00 4000,00 9300.00 5000.00 9300.00 5000. rlvaala Balt Xfg. Ster of Balaaoo duo from 1 9 4 ? ....... .......... 9000.00 tecolota 1948 ....... . . . . . . . . . 4000.00 TWO* Balaaoo duo om 1948 Appropriatiam aooo.oo 9000.00 )lda Metals Stero of Baiane duo Rooolpts 1948 as X 1947 . . 4000.00 8000.00 -TRWTW 4000.00 4000.00 Riversai Oil PredueU Stero of Rooolpts 1948 ............... Baiane duo Bm 1948 Appropriati 1000.00 0000.00 1000.00 API 04838 ____ otiybrsity or c a c i w u f i KSTT&HI10 LABORATORY QF APPLI PHYSIOLOGY ACCOORT or TH1 PLOORII PRQJBCT 1943 (Basad os Proportion of Tine Actually Spant on Project) ^ rt A. Yahoo pel* Hayroth yd U r g a n t ,ob Chola if 0k Outra jorla C h r is tia n 0 La*ick 0 Black*ton yle* Pox 1 Broarlng i S ellar i* Blaekston fl* 9;Mtuhiichel* 'Appal >lden l 8l0Mn Supervision (Oanaral) Sapervi ion Principal lava*tigstor Supervisor of Analytical Work Pathological Assistance Rsvlev of Literatura lavlav of Literature Analytical Asst, and Axperlaontal Analytical Assistance Sub. BOOS MOTHS* food and Aspan*as Incurred in the Collection of Saaplea by Ixperinastai Subject............... laboratory Supplies tlon of Secretarial, Library, Wash Boya, Shipping Clarks, Draftasan ate . . . . . . . . . . . . . . . . . Proportion of Beat, lee,, Talfibone, Paatago, Bleatrialty, Pensions, Annuitioa. Postage, nalntananaa ate . . . . . 303 59.56 1779.72 239.94 22.67 1300.00 36.10 1312.03 903.98 606.06 464.25 131.10 49.00 426.67 9T.02 415.08 205.30 3637.36 2 0 3 7 .0 0 2923.54 2177*33 3047.43 TOTAL................... Receipts 1948 ................. . 16,500.00 halaaca due on 1943 appropriation 3.000.00 Total Receipts Tovard proeeeutlon of Progran............ . . 19,500.00 Total Expenditure* 1943 ........ Balance P-- 1n1i^ for 1949 . . . . 18.823.21 $ 676.79 13,323*21 API 04839 Copy from D. V. Stroop for Information of Members and Associates of API Medical Advisory Committee. ..................... . ........ 3-1U-U9 March 8, 19^9 Dr. W. A. LaLande, Jr., Pennsylvania Salt Manufacturing Co. Mr. C. 0. Henke, E. I. du Pont de Nemours and Co. Dr. D. A. Irwin, Aluminum Company of America Mr. Basil Horsfield, Reynolds Metals Co. Mr. E. M. Matson, Universal Oil Products Co. Mr. D. V. Stroop, American Petroleum Institute Gentlemen: Prior to our meeting on March 30, I send herewith the summarized account of all expenditures made in connection with the work on fluorides for the year I9U8. All receipts have been included and are itemized on the second sheet of the account. In accordance with my best Judgment, I have assumed that the contribution of the American Petroleum Institute (which has been continued for a second year) should be added to the sum to be spent in I9W . This has made it possible to provide the services of the library without curtailing the experimental work, and also to absorb the Increase in the cost of experimentation (over that estimated in 19h6) represented in necessary increases in the salaries of personnel and increases in the cost of supplies of all kinds. I trust that this will meet general approval, but the matter should be discussed at the meeting and a policy decided upon for the future. The cost of the library work will be decreased considerably in 19^9, since the intensive work of surveying prior I literature has been done. This will provide additional funds for i the experimental work proper. It was necessary to curtail the work somewhat in the last quarter of 19W , so as not to make in roads upon the funds available for subsequent years. Sincerely yours, RAK ef Dictated but not read. Enc. // Robert A. Kehoe Robert A. Kehoe, M.D. API 04840 API 04841 UNIVERSITY OF CINCINNATI KETTERING LABORATORY OF APPLIED PHYSIOLOGY ACCOUNT OF THE FLUORINE PROJECT . 19W SALARIES (Based, on Proportion of Tine Actually Spent on Project) Robert A. Kehoe Francis Heyroth Edvard Largent Jacob Cholak Frank Dutra Marjorie Christian John Lesick Elmo Blackston Charles Fox Leo Broering Jim Zoller Morris Blackston Jim Roth Anton Michels John Cappel Vm. Holden Howard Sigmon - Supervision (General) $ - Supervision - Principal Investigator - Supervisor of Analytical Work - Pathological Assistance - Reviev of Literature - Reviev of Literature - Analytical Asst, and Experimental. Sub. - Analytical Assistance _ f` If _ ft ft It tf tt tt ft tt ft tf It If 8.33 59.56 1,779-72 239.91* 22.67 1 ,800.00 36.10 1 ,312.08 983.98 606.06 h64.25 131.10 1*9.00 1*26.67 97.02 1*1 5 .0 8 205.80 8,637.36 MISCELLANEOUS EXPENSE Food and Expenses Incurred in the Collection of Samples by Experimental Subject .............................. Laboratory Supplies ........................... Proportion of Secretarial, Library, Wash Boys, Shipping Clerks, Draftsman, etc............................... Proportion of Heat, Gas, Telephone, Postage, Electricity, Pensions, Annuities, Postage, Maintenance, etc....... 2,037.00 2,923.54 2,177.88 3,047.43 TOTAL 18, 823.21 Receipts 1948 ......................... $ 16,500.00 Balance due on 1948 Appropriation.... 3 ,000.00 Total Receipts Toward Prosecution of P r o g r a m ......................... Total Expenditures 1948 .............. 19,500.00 1 8 ,823.21 Balance Remaining for 1949 ........... 676.79 API 04842 ) m ih itebs SUBCOMMITTEE OH CISC IHOOSBI CITY March II, 1?^9 A meeting of the Subcommittee on Carcinogenicity was convened, at 10 A,iM., Triday, March 11th, 19^9. at 15 West 51st Street, Hew Tork City. . ywHEBS FBB8WT .1. Hoag J.P. Holt W.B. levis M.H. lewquist Mclver Woody ftOESTSt H.S. Bonsib A.B. Dooley H.O.M. Tischer H.F. Lankelma K.S. MacKensie A.W, Horton University of Cincinnati * J.J. Phalr- University of Cincinnati D.Y. Stroqp American Petroleum Institute TOTAL IH AfTZHDAVCS - 13 gHBlSS ABSEHT: L.X. Curtis T.M. Trank T.J. Hally II C.A. Swan L.C. Beard AJi K oevingt Jr* \ H.H. Zuidema ' Dr. J.J. Phair, Professor of Preventive Medicine, University of Cincinnati, was introduced. Minutes of the seating of Pebruary 1st were Approved. Dr. Horton reported that his laboratory equipment is being assembled and his new facilities will be available about May 1st. In the mantime, he is visiting refineries and studying the various types of catalytic cracking units and their operation for the purpose of making the proper choice of samples. He stated that Shell had offered to cooperate in a pilot-plant operation to yield ! samples which could be used to determine effects of variables, such as natures of API 04843 ) * fei, temperature, rate of through-put, etc. Be thought this approach to the problem might yield, valuable data and eamplee that could be studied concurrently vith: (a) the search for an analytical tool, and (b) the animal testing of the list of materials recommended by the technical advisors to the Subcommittee in Its January 31st, 19^9 meeting. Sr. Holt said that beforB deciding on the Inclusion of the pilot plant approach, the technical advisors should be consulted. Nr. ?ischer felt that the pilot plant phase, while of scientific interest, might not answer the practical problems because of the great variations in feed stocks. He feared that it might bog down the animal testing program and believed that it ghould receive a low priority until answers to the practical phases of the problem Had been obtained. Nr. Bonsib agreed with Mr. JTischer's comments because of the feedstocks. 'Jr' variations in " Sr. Horton replied that refinery sasples would present these same variations and cosplicatlons. It was hia plan to get the pilot plant runs on three selected feeds containing; 0, 30 and 60 per cent aromatics respectively. Mr. lankelma, while agreeing with Mr. Vlseher, believed that sooner or later this phase would have to be a part of the study. Nr. Mackenzie thought that the nature of the charge stock was of minor importance compared to operating conditions; and that one run on a paraffinic Btock should settle the question of the effects of time and temperature. Nr. iischer said that his company had tested sauries from different feed stocks and had concluded that fluid-catalytic cracking operations presented a carcino genicity problem. He recommended that the analytical study be given priority. Dr Horton urged that Shell's offer be considered because of the time required ito prepare the samples. He pointed out that oil 3^32 wae being fractionated and that the fractions would be tested on animals, in attempt was being made to Isolate the carcinogens in hope of obtaining an analytical tool. Zt wa^ the unanimous opinion of the Subcommittee that the analytical work on oil 3632 should go ahead. Dr. Horton said that this analytical work may be long and complex; he thought that the other phases should not be delayed. Dr. Holt divided the problem into four aspects: ' 1. Does a problem exlstf That was the question two or three yearB ago. Work to date indicates that there 1b a potential problem. -2API 04844  \ 2. Where does it exist; in what operation, oils, fractions, materials, etc. is there a hazard that requires protective measures? 3* Can these operations be changed to control the problem) k. Development of a technique to eliminate animal testing. If a study of the processes were added, there would not be sufficient facilities available. He recommended that a list be made of all samples to be studied and that the Subcommittee then schedule them for priority in testing. Kr. iischer said that such a list of samples had been approved at the last meeting of the technical advisors and that Dr. Horton was to collect the samples listed and report to the Subcommittee. The proposed schedule of testing them and the analytical work on oil j6jZ should be continued concurrently. His personal view was that samples obtained from a pilot plant run should be placed way down on the list. Dr. Horton estimated that when the new facilities are available about June 1st, if,500 mice could be handled which would mean that 150 to 200 samples could be undergoing tests at one time. Dr. Hoag said that the first oils to study were those to which exposures are now occurring, in order to determine control measures. Dr. Hewquiat was of the opinion that, while it was very Important to test various oils in order to determine which ones present a hazard and call for protective ~ measures; nevertheless, the analytical work should be continued. Also, because of the limited number of samples that can be tested, the pilot plant studies should get under way. . Dr. Voody said that this question would be up for discussion again at the April meeting in Detreit and that, in the meantime. Dr. Horton would discuss it with Dr. Zehoe and Dr. Heyroth. Dr. Holt proposed that Dr. Horton prepare a summary showing the total number of samples that may be desirable to study at Cincinnati between July 19^9 and July 1951 and the order in which they should be studied. Dr. Horton agreed to submit such a list by Nay 15th. Deporting on the Hational Cancer Conference recently held in Memphis, Dr. Hoag said that Dr. Holt and Mr. Tischer were to be congratulated on their handling of the subject. Dr. Hewqulst added that tEe cancer question was now an open story. He also commended Dr. Holt for his presentation; no hysteria was aroused and what was said was not embarrassing. Dr. Voody submitted a revision of our confidential memorandum of April 2nd, 19^8 proposed by Dr. Curtis. On page 3, the third sentence in the last paragraph was changed to read as follows: -3- ) 1 "Experiments in the laboratory have shown that certain of the high-boiling materials from these newer processes cause the de velopment of tumors and cancers on mice." and the foot-note was omitted. Dr. Fhair said that he planned to get acquainted with the medical directors of the Tarius companies to see what medical records are available and to determine whether epidemiological techniques could be applied to advantage. The long "incubation period" was one of the factors that complicated the problem. The adoption of control measures might be better than attempts to eliminate the hazard. In re sponse to a question from Dr. Eewquist, Dr. Fhair said that a cancer registry for the petroleum industry was an inherent objective of the control program. He added that he had doubts as to the successful enforcement of laws requiring the reporting of cancer cases, as has been proposed by some investigators. The next meeting of the Subcommittee will be held in Detroit April 1st, 19**9. A.i, Dooley Secretary Hclver Woody Chairman API 04846 PERSONAL AMD COHFIDENTIAL MEMORANDUM FOR INFORMATION OF W. R. BOYD, JR.. PRESIDENT. AMERICAN PETROLEUM INSTITUTE It has "been stated that petroleum products cause cancer. To the informed, this sounds like a very serious matter and in the interest of undergt&nding and proper evaluation of such a statement, the following facts are presented. Very little is accurately known about the causes of cancer. Causative jgents which have been cited in the Technical Literature include soot, coal and ^ s tar, asphalt, crude oil, unrefined paraffin wax, certain chemicals, pitch, arsenic compounds, nickel compounds, chromium compounds, and sunlight. It has also been recently proposed that cosmic rays may contribute to cancer. There is also medical evidence, although controversial, that mechanical irritations such as injuries caused by blows may be contributive. Other possible producing causes yhich have been cited are Internal secretions produced by the body Itself. The number of cases of cancer reported to have been caused by contact vith industrial materials is exceedingly small as compared to those which arise from unknown causes. With regard to the petroleum Industry, few cases of cancer have been reported. Reference is made to the Government Bulletin No. 28U of the U. S. Public Health Service from which the' following abstract is taken: Disabling morbidity and mortality from cancer amoxg male employees of oil refining company with reference to age, site and duration. V. M. Gafafer and Fosedith Sitgreaves. Public Health Reports 55: 1517 (Aug. 23) 19*0. "The authors studied the records of the members of a sick benefit plan connected with an oil refining company. The study covers a period of 6 years, from 1933 to 1936, during which there'was approximately' 60,000 years of membership for the male employees. There were 70 cases of cancer, *6 of which ended in death. The eases which did not end in death terminated in recovery or in sufficient improvement for return to work. The *6 death* yield an average annual death rate of 0.78 per thousand. The population exposed represents an age distribution ranging approximately from 15 to 69 years. The calculated crude death rate from cancer for white males from 15 to 69 years of age throughout the entire United States far the years 1933 to 1937 is 0.96 per thousand, while the experience of the industrial department of a large life Insurance company for 1935 gives a rate of 0.86. Previous studies have indicated that certain types of mineral oils possess carcinogenic activity; the present experience le therefore not unfavorable The above quotation shows that up to 193d, mortality per thousand du e w w e ? fro 11 cause a in the petrbleum industry, as represented fey this group, was less than in the United States aa a whole*. * - 2- 'l Turning now to the reports In the medical literature that petroleum oducts cause cancer, ve find the following: Clinical and experimental data show a great difference in the carcinogenic (cancer causing) properties of semi-refined and refined oils and paraffin waxes, depending, in part, upon the chemical composition of the raw materials and, in part, upon the method of fractionation, distillation and refining (1). According to Schwartz (2) oils derived from shales are more carcinogenic than petroleum oils, while pure medicinal petroleum oils are non-carcinogenic. Scott and others (3) (U) have reported the occurrence of a signifi cant incidence of skin cancer among workers in Scottish shale oil refineries. He noted that in these workers malignancy was preceded by the presence of warty growths, and that the change of these growths to cancer could occur long after withdrawal from exposure. The so-callsd "mule spinner's cancer," which generally involves the scrotum, occurring among textile workers in the cotton textile Industry in England, is the commonest cancer associated with oils. In the process of operating the machine (mule) that makes the yarn, the mule spinners have skin contact with the oil that is used to lubricate the spindles. A study of the problem by a committee appointed by the British Government (5) indicated that the high Incidence of scrotal cancer among mule spinners was a result of long contact with lubricants of the type used. Altogether 3^5 scrotal cancers causing death among mule spinners were reported in England from 1911 to 1935 (6). Only six reports of mule spinner's cancer are on record in the U.S.A., and only two of those were positively contracted as a result of exposure in the United States (1). The difference In the origin of lubricants is presumed to account for the variation in incidence of the disease. Individuals employed in filter press operations in which paraffin wax is separated from certain petroleum oils have been reported by Heller and others (7) (1) to develop skin cancer. Wood (8) states that pure paraffin wax is not productive of cancer and Schwartz (2) reports that workers with refined white paraffin do not suffer from dermatoses, epitheliomas (skin cancers), or papillomas (wart-like growths) which affect those who handle crude paraffin wax. Schwartz (2) has reported the presence of epitheliomas in oil field workers In California. Individuals who developed cancer troa exposure to oil or paraffin wax have gonerally been exposed to the material for a period of from 10 to 50 years (1). The mortality, based on certain English statistics, from paraffin wax cancer was 13 per cent, and frem mule spinner's cancer 51 per cent of those having cancers (1). Approximately U3 cases of paraffin cancer have been reported in Germany and Austria; a few cases of oil cancer in France; about 150 cases of paraffin wax cancer and over 1,500 cases of oil cancer have been reported in Great Britain; in the United States approximately 50 paraffin wax and 12 oil cancers have been reported (1). API 04848 % -3- From this information It la clear that fev cases have been reported In this country compared to the number of cases that bare been reported in England. This appears to be due to the fact that the mineral oils that have been used in this country vere much less carcinogenic than certain oils from shale used in England; for example, It Is stated (1), on the basis of experimental studies, that refined American oils vere only one-twelfth as potent in the production of cancer as oil from shale and that a worker in contact with Pennsylvania oil Is only one-fiftieth as likely to develop skin cancer as a worker exposed to oil from shale. Experimental studies on mice with various fractions of crude shale oil (9) shoved these materials to be carcinogenic; while experimental studies on mice by Tvort and Ing (10) on various brands of purified liquid paraffin oils shoved these products to be non-carcinogenlc. Davis states (11) that animal experimental studies on slack wax and pressed distillate have failed to cause cancer of the skin. Extensive experimental studies by Tvort and associates (12) demonstrated the carcinogenic properties and potency of certain crude and refined mineral oils. Epitheliomas of the skin caused by occupational contact with mineral oil and paraffin are Included among the compensable diseases in Argentina, Australia (Wst Australia and Queensland), Belgium, Cuba, Great Britain, Ireland, Rumania, Venezuela, Germany, Russia and Mexico and in the U.S.A., the states of California, Connecticut, District of Columbia, Illinois, Indiana, Massachusetts, Missouri, New York, North Dakota, North Carolina, Wisconsin, Ohio, Pennsylvania, Rhode Island and Washington (1). At first glance, the above evidence may seem formidable, but let us examine the matter a little more closely. First, those hydrocarbons which cause skin cancers are relatively high boiling (above 700F.). Such compounds, therefore, are not found in gasoline, kerosene, and home heating oils. Lubricating oils generally are treated with sulphuric acid or other agents vhich will remove a substantial portion of any cancer-causing materials that aay be present. American crude oils, according to the record, contain less cancer-causing materials than oils from shale vhich were largely responsible for the initial unfavorable shoving experienced by the British textile industry in the use of lubricating oils from shale. The petroleum industry has been studying the possibility that products from the never processes of refining are more carcinogenic than those used before the war. To date, there is no evidence of cancer among employees that can be attributed to exposure to those products. Experiments in the laboratory have shown that certain of the high-boiling materials from these sever processes cause the development of tumors and cancers on mice. Products derived from certain sources and processes that have been employed for many fears have shown a similar tendency to some degree. Extensive vork is In progress in biological and analytical laboratories with the objective of developing a clearer understanding and a better knowledge of the compounds that possess carcinogenic activity and the p r o c e s s features that may in f l u e n c e uch activity.  -k- The question naturally arises as to what protection can be afforded, jjje most Important protective measure is personal cleanliness, and this applies only to workers in the petroleum industry, but also to those who use petroleum products. Oil-impermeable protective outer garments, clean underclothing, and daily showers at the end of work are recommended as well as periodic medical examinations. In other words, with adequate medical supervision pad the pursuit of habits of cleanliness, the chances of industrial cancer from petroleum are remote. This confidential memorandum summarizes the primary sources of information known to members of the Institute's Medical Advisory Committee vhlch has recanmended its transmittal to the President for such use as he may deem necessary or desirable. Submitted by: M. N. Newquist, M.D. Chairman, Medical Advisory Committee. U2-Ufl Amended 3- H - U 9 API 04850 > -5- REFERENCES ]_ Hueper, W.C.: Occupational Tumors and Allied Diseasos, Charles C. Thomas, ' Springfield, 111., (l9*+2). 2. Schwartz, L., Tulipan, L. and S. M. Peck: Occupational Diseases of the Skin, Lea and Fohiger, Philadelphia (191+7)* VJI 3 . Scott, A.: Cancers in Mineral Oil Refineries, Report of the International Conference on Cancer, London, July, 1928, held, under the Auspices of the British Empire Cancer Campaign, Bristol, John Wright and Sons, 1928, p. 27 J. Ind. Hyg. and Toxicol. Ah. 11:28, 1929. 1*., Kennaway, E. L.: The Anatomical Distribution of the Occupational Cancers. J. Ind. Hyg. and Toxicol. 7:69, 1925. 5. Report of Departmental Committee appointed to consider evidence as to the Occurrence of Ep1theliomatous Ulceration among Mule Spinners. London, H.M. Stationery Office, 1926. Cited in Heller, I.: Occupational Cancer, J. Ind. Hyg. 12:169-197, 1930. 6. Henry, S. A.: The Study of Fatal Cases of Cancer of the Scrotum from 1911 1935 in relation to Occupation, with Special Reference to Chimney Sweeping and Cotton Mule Spinning, Am. J. Cancer, 31:28, 1937* 7. Heller, I.: Occupational Cancers J. Ind. Hyg. 12:169-197, 1930. 8. Wood, H. B.: 13:97, 1929. Paraffin not Productive of Cancer, Jour. Cancer Research, 9. Leitch, A.: Brit. Med. J., 2:110l+, 1922. 10. Twort, C.C. and H. R. Ing: Lancet, 1:752, 1928, Ztach, f. Krehsforsch, 27:308, 1928. 11. Davis, B. F., J.A.M.A., 62:1716, 19H+. 12. Twort, C. C. and J. M. Twort: Lancet, 1:1331, 1930; 1:286, 193*+; 2:1226, 1935. J. Hyg, 29:373, 1930, Ztsch. f. Krehsforsch, 32:1+91, 1930, J. Ind. Hyg. 13:1931, Am. J. Cancer 17:293, 1933, Oil and Color Trades Journal, Oct 22, 1937; Twort, C . C . and J.D. Fulton, J. Path, and Bact. 32:11+9, 1929, Ztsch f. Krehsforsch, 35:51+3, 1932; Twort, C. C. and R. Lyth, J. Hyg., 33:1+61+, 1933; Twort, C. C. and H. R. Ing., Lancet 1:752, 1928, Ztsch, f. Krehafarsch, 27:308, 1928. API 04851 MprffBRS pmngtarr Marshall Clinton L. E. Curtis T.M. Trank J.P. Holt / T.J. Belly M. H. Hewquist Melver Woody visitors T.C. Baird T.T. Boys Bleffer Davis A. X. Hoag X.X. U n d e r X.P. Luongo H. Clinton Page B. B. Reeve QUESTS S.J.M. Anld R.D. Bent = J.W, Eaeeond RJL. Iehoe~; V.l. Siepsen J.B. Stackers - H.O.S. vaaRaalte IJl.lWarriok - . Minutes of Meeting April 1, 1949 Book-Cadillac Hotel Detroit, Michigan ASSOCIATES PHISENT l.c. Beard, Jr.Y R.S. Bonsih A.X. Dooley H. O.M. Tiseher * HJP. Lankwlma I. Q. Mackenzie/ H.H. Zuldema-/ X.W. R.C. X.J. R.M. T.M. Adaes Cole Oothard landon Watkins Institute of Petroleum, London Atlantie Refining Company, Philadelphia Bnnhle Oil Coepany, Houston University of Cincinnati Detroit Institute of Cancer Research Pore Oil Coepany, Chicago / Shell Oil Coepany, Curacao, Beth. Antill. Bxe Texas Coepany, lev York >- D.Y. Stroop - API MPTHKBS ABSXHT W.R. Levis C.A. SvaB TOTAL II ATTXSDABCX - 36 < API 04852 ) * Hew Bernier* of the Subcommittee and guests were Introduced. Minutes of the three previous meetings, November 11th, 19U8, February 1st, ^^9 and March 11th, 19^9 were approved after a change was made on Page 3, Line 9 / the March 11th, 19^9 minutes by substituting the word "suggested" for "approved". Dr.. Eehoe stated that of the $h-0,000. capital funds provided by the jpj, $30,^78. had been applied to building costs and $8,26^. had been put into jpeoial equipment, leaving a balance of $1 ,258 to provide additional equipment as needed. Of the API grant for current expenditure, there remained a balance of |22,598. as of December 31t, 19^8, of which about $1U,660. would be used during gie first six months of thiB year, giving a balance of some $7,000. as of July 1st, 191*9. Current expenses from July 1st, I91+9 to June 30th, 1950 were estimated at $122,600., of which about 25^ would be covered by from payments from individual companies for testing their samples, leaving some $90,000. to $100,000. to be provided by the API. Thanks to the API grant for capital expenditures, which came in the nick 0f time, facilities would be available by July 1st for a colony of 10,000 mice which yould permit simultaneous studies on 175 to 200 samples. The API would have first claim on these facilities; but after that, samples submitted by any individual company would be accepted for testing provided that they would not interfere with API schedule. In addition to Dr. Eehoe, Dr. Heyroth and Dr. Dutra, 11 other persons would be required. Of these, Dr. A. Wesley Horton was already engaged in securing the necessary refinery and chemical data. Dr. J.J. Phair would start work on the epidemiological phases of the problem after July 1st. Other personnel would in clude: a chemist to assist Dr. Horton; a record clerk to maintain complete records on all the mice; three technicians to do the actual application of samples to the nice; one technician to prepare tissue sections for the pathologist; and two animal caretakers. A principal investigator was yet to be selected. This investigator would have to be an excellent pathologist, as well as a good administrator because he would be responsible for: . a. Supervising application of the samples to the mice. b. Establishing standard criteria for: 1. Determining existence of tumors. 2. Differentiating between tumors and dermatitis. 3. Establishing whether tumors are benign or malignant. Dr. Hewauist asked about the method of selecting samples for testing. Dr. Eehoe replied that this would be the duty of Dr. Horton, working with the Subcommittee and its technical advisors. Mr. Beard asked \diether results of tests of samples submitted by indi vidual companies would be available to the API. Dr. Eehoe said they would be available only with the consent of the particular company and then only on a confidential basis. Mr. Fischer thought the proposed program was well organized but wondered Aether the personnel proposed by Dr. Eehoe would be sufficient to carry on all the necessary work. -2API 04853 I * Dr. Hewoulst thought experiments on primates should he started at an e8rly at because of the time required to get results. Dr. Kehoe replied that jnvestigators of carcinogenicity of petroleum and Its products had two objectives: first, to find a tool for determining potencies; and second, to determine whether results of animal tests are applicable to man. The first phase required a group 0f stable, non-variable animals, such as the highly inbred C-H mouse strain, jhis stability and lack of variability between the individual animals was not found in primates. As to the second phase, there was no definite evidence as yet that the results obtained in mice were applicable to man. It might be necessary to use other animals to establish the relationship. In that case, the laboratory bad other animals available and, while it was not anticipated that monkeys would be used at first, this might be done later. Human experiments could not be set no until a good deal more information and knowledge was available, and even then only carried out under his personal responsibility. Dr. Simoson pointed out that since susceptibility varies between in dividuals and since humans are not homogeneous, any tests on humans would have to be done with statistically significant groups (many thousands) and that there fore, as far as establishing potencies is concerned, this approach would not be practical. Furthermore, a carcinogen too low in amount to produce a local Q p reaction, might be absorbed and produce a carcinoma elsewhere in the body. Col. S.J.M. Auld. Chairman of the Research Group of the Institute of Petroleum, London, described the carcinogenicity problem in England and asked for an exchange of information between the API and the Institute of Petroleum. Hule spinner's cancer was still a problem in England, 20 deaths having occurred in 19^7 After the earlier work in the nineteen twenties, there had been a lull but the subject was brought up again stfter the war, largely due to the action of the trade unions. The University of Birmingham had started research work and had found that extracts from solvent refining operations produced skin conditions which were "core than a mere dermatitis". More recently suspicion had been cast on some cutting oils and some motor oils from Scotland (not shale oils). The publicity attending the use of mineral oils as cooking oils during the war caused the Government to enter the picture with the result that the Medical Research Council (a government group) and the Institute of Petroleum (which succeeded the Petroleum Board) were now cooperating as a joint committee. Under the direction of Messrs. Squiers, Cook, Ferguson, Woodhouse, Irvine and Auld, a long-range research study has been started, beginning with an investigation of these three crudes: Yenezuelan crude - naphthenic type Middle East crude - Kuwait Mid-Continent crude (USA) - of importance in lubricants. A certain amount of support was given still to the unfortunate formula by Twort regarding refractivity; but later work indicated that the higher the aromaticity, the higher the carcinogenicity. The industry in England had made white oils available but there has been little demand for them as yet. There was no evidence that solvent refined oils are carcinogenic. Shale oils were going out of the picture. Some preliminary idea on potency of oils might possibly be had by determining their effects on plants. It appeared that the fractions which are the most active plant poisons are those that seem to possess the highest carcino g e n ic p o te n c y and that perhaps by fractionating the oils and testing these API 04854 J * factions on plants some index of carcinogenicity night he developed. Dr. Woody read a letter from the American Cancer Society requesting API to report the anount of money it was spending on cancer research, so the Society could include i.t in their report of grante-in-aid for cancer research, lb-. Stroop was asked to obtain information on how this data would he used hy the jnerican Cancer Society. Action hy the Subcommittee - It was voted to recommend to the Medical divsory Committee thatl 1 - Information on carcinogenicity he exchanged with the Institute of Petroleum. 2 - The budget for the year beginning July 1st, 19*^9 ! for the program at Kettering Laboratory he in creased to $100,000.00 A.Z. Dooley Secre tary Mclver Moody Chairman -fcAPI 04855 *wC _ I c -'* 1 1 I AMERICAS PETROLEUM INSTITUTE SUBCOMMITTEE OH CARCIBOQElTICIfT MISUTBS Of IVTEHIM MEETIBO June 1, 1949 An interin nesting of the Suhcomnittee on Carcinogenicity was held on Priday, June 3rd, 1949, at 15 Beet 51et Street, lew Tor* City. MEMBERS P B B S P T ASSOCIATES PHESZVT Marshall Clinton T.M. Prank A.Z. Hoag J.P. Holt T.J. lelly M.V. Vewquist Melver Woody CHESTS L.C Beard, Jr. H.P Lankelna I.G Nackensie B.M Shepardson (representing B.9.M. Tiseher) H.H Zuideaa R.W. Paulk - Shell Oil Coapany A. Wesley Horton - University of Cincinnati AgnsQI D.V. Stroop - API TOTAL IV ATTEEDAICS - 15 MEMBERS ABSEVT ASSOCIATES 1B8EVT L.E. Curtis W.R. Leris C.A. Swan B.S. Bonsih AJC. Dooley H.C.M. Pischer Minutes of the nesting of March 11th were approved as issued. Mr. Stroop stated that the API prefers not to he included in the Anerican Cancer Society's list of grants-in-aid for cancer research. Dr. Horton submitted a progress report. attached ae Appendix A) . (Copy of the report is Dr. Woody said the Pederal Security Administration has awarded over $450,000. in federal grants for cancer control and teaching activities. The API 04856 ! vi largest amount, $35,000. went to the Pennsylvania Department of Health, where Dr. Shllen, Director of the Division of Industrial Hygiene, has set up an occupational cancer control program with a physician and a nurse. At a later date, two engineers and a statistician will he assigned to the project. The attached forms (Appendix B) are being prepared i n quantity for use in their surveys and are essentially identical with the form submitted to them by Dr. Hueper to insure uniform data from the various states participating in the industrial eancer program. The oil industries located in the Philadelphia area are high on their agenda. Dr. Hoag and Dr. Bewqulst spoke briefly concerning articles on cancer they have written for the Secony-Vacuua lews and Texaco Topics re spectively. It was agreed that other companies could well afford to follow their example. T.M. PHASE Secretary MeITER MOOD! Chairman i API 04857 I * A F F U D I X A. API PROJECT ON CARCINOGENICITY AT THE UNIVERSITY OF CINCINNATI The program at the Kettering Laboratory is roughly divided into three major phases. Of perhaps most immediate importance is the effort to pin point throughout the industry materials and operations which represent potential hazards from the cancer standpoint. The second phase, which will be prosecuted simultaneously with the first phase, will involve the concentration and isolation of the compounds re sponsible for the carcinogenic action of certain catalytically cracked oils which have already been tested biologically. From the physical and chemical properties of such concentrates, an effort will be made to develop an analytical tool which may then be applied to any refinery stream to determine its carcinogenicity without resorting to animal testing. The third major phase will be an epidemiological study of cancer in the petroleum industry. In carrying out the first phase in the program, as described above, a series of typical refinery samples will be tested on suitable laboratory animals to determine their relative carcinogenic potencies. It is expected that, in the course of the coming year ending June 1. 1950, testing of approximately 150 to 200 such samples will be started at the Kettering Laboratory. Thus an average of about 12 samples from each of the following processes will be studied: 1. 2. 3. A. 5. 6. 7. 8. 9. 10. 11. 12. ]3* Non-catalytic gas oil cracking Viscosity breaking of residues and extracts Naphtha reforming Polyforming Coking operations Houdry catalytic cracking Fluid catalytic cracking Thermofor catalytic cracking Cycloversion Houdryilow cracking Hydroforming Slack waxes and aromatic extracts therefrom Solvent extracts from lube oils and heavy gas oils. API 04858 I } - 2- The potencies of the samples will be compared with those of coal tar and shale oil fractions on which clinical data is available from England. In considering the selection of samples from each of the processes listed, attention is at present being re stricted to those intermediates or products with a distilla tion end point above 650CF. On the basis of confidential information supplied to the Kettering Laboratory by each of the API member companies on such materials and the unit operations producing them, a sampling program is being organized which will cover the current range of variations in each process. Careful consideration is being given not only to the characteristics of the particular products which will be tested for carcinogenicity but to the feed stocks and the unit operating conditions as well. In this manner it will be possible to correlate the effect of the trends in available charge stocks and refining practices with the relative carcinogenic potencies of products formed. Thus, the results of the testing program now planned should permit prediction of potential hazards as unit operations change in the years to come. As yet, a list of the specific samples to be tested during the coming year has not been prepared since the necessary data from the individual companies is not complete. However, sufficient information is available to permit the selection of a small number of samples from thermal cracking of high boiling materials, both virgin gas oils and those previously subjected to catalytic cracking. In addition it is planned to request samples of high boiling oils from TCC units since to date no physiological testing of the heaviest products from these operations has been carried out. In reporting results of tests on future oil samples, a direct comparison with a solution of a known concentration of a standard carcinogenic hydrocarbon in a standard solvent will be made. Preliminary tests are being run w i t h solu tions of methylcholanthrene in benzene, at concentrations from 0.01J6 t % 0.6$. Previous results have indicated that the tumor incidence curves for typical heavy catalytically 04859 API I I - 3 - cracked oils may be compared nicely with the curves for such standard solutions. In further work the effect of the benzene solvent on the tumor incidence and the induction period in mice will be determined. Various non-volatile solvents, such as methylnaphthalene, are being considered for this purpose. However, it must be kept in mind that benzene solutions of methylcholanthrene have been employed as standards for many years in studies by English scientists. Their use 4 may therefore facilitate the interpretation of our laboratory results in terms of practical hazards to exposed workers. 'It June 3, 1949. k. Wesley Horton API 04860 iPPSHDIX B API 04861 1 . Name Resldenoe 3. Statei 2 . ria c a of Death: C ity : C ity: U o sp ltd : S tre e t: 4 . 3 o o le i S e a u rlty No. 7 . Date o f B ir th : . 5. Sex Age 8 . T e a r s : M0 3 . Days: 6 . Color or Race: 9 . Date of Death: 1 0 . Occupation: 1 2 . Cause c f Death: 1 1 . In d u stry or B u sin e ss: lietbod of Diagnosis 13. C lin ical: B io p sy : Autopsy: O ther: jl4 . Naira o f P h y s ic ia n : 15. S treet: 16. C ity: 1 7 . C lin ic a l D iagnosis: 18. P athologic D iagnosis: 1 9 . Primary S i t e : 0 . Date o f F i r s t Symptoms: 2 1 . Date of F ir s t V is it to P h y slolan : 2 2 . Date o f F ir s t D iagnosis: 2 4 . H istory of Other I lln e s s e s of S it e A ffected : 2 3 . Stage of Disease e t F ir s t D iagnosis: 2 5 . H istory of In ju ry to S it e A ffe cte d : 2 6 . Exposura"; HAKE OF SUBSTANCE Hava you e r a r tend le d or worked u aar any o f t h e fo llo w in g ? I f y e a , gW e d ate l i e . NAME 0* B T L 0 Y E R DATS LENGTH OT EXPOSIP. E : D ESCRIBE T IP S OF EICPOSUP-E AND ESTO1AT2 U R C B JT OF l 7.0RKIHG H U E EXPOSED: - I ) at B IH -C -lb Occupational Cancar Reoord - Paga 3 27. O ccupational H is to ry : L i s t Occupations ln C h ro n o lo g ie n Order b eginning vrlth l a s t or p re sen t one. Dates THDlt TO j . TYPE CF 3C3IK3SS FAME OF a<H,0YER ' ADCRESS OF 91P1OT0R 1 CR PHODICT MADE TITLE OF J<B THE OF DOUC PERFORMED 1 i ! _ ______1_____________________ APPENDIX B API 04862 2 8 . Are th e re any o th e r Important mete r i a l s to which you have been ezposed? (Hobbies; H abits; ta d ic in e s ; C osm etics; D ie ts; Environment) 29. A dditional Inform ation Obtainable a t: (L is t P h y sician ; Leboratory; H osp ital; Insurance Co; P lan t Medical Deirtm snt ___________________________________________ C l i n ic ; Tumor R e g is try , e t c . ) Mama *>ane: Address: Address: Mane;_____________________________________________________________ Address:_________ 3 0 . Any o th e r Inform ation p erta in in g to Tumor (M u lt ip lic it y , s i t e s , e t c . ) : *4 % H tri 1 2 . Sex o f exposed w ertere: M ele: Fem ale: 14. Duration o f exposure: Kumber: Number: number: 1 5 . R ate o f tu m o rer In exposed group (a ) ' 5 . Cancere Obserred in exposed group ( s ) 17. Cancers by s it e s : 13. Roce: Teere: Teere: Teers: W hite: Colored T o ta l number: P erio d : kPX 04863  iPfianiii b BIH-C-3 X . Mane o f Conpany: PLAHT CANCER RECORD D ate: t. Location: 3. In Operation sln ee: 4. P rod ucts M anufactured: S. Wunber o f W orkers: T o ta l Penales K ales White Colored Office: P ro d u ctio n : 6. Kane o f P la n t M anager: __ 7. P lant Physician: 8. In su ra n ce C a r r ie r : 9, C arcin o g en ic Hazards : 10. Operations Involved a b e d e f e h 1 i k 1 Number o f Workers T o ta l. White Colored Male ren a le Erp oeure Constant In term itten t O ccasional n 11. Type o f Exposure In h alatio n Skin In g estio n Other a b e d e f 8 h 1 J k 1 m n Duration o f Exposure Average Longest Cancers Observed S it e Nuaber Period 12. Sate o f Labor Turnover: API 04864 U N IV ER SIT Y O F CINCINNATI ' C O L U 8 I O P M KDICINK CIN CIN N A TI l > . OH IO LABORATORY OP APPUCD PHYSIOLOGY June 2D, 1949 Mr. D. V. Stroop, The American Petroleum 50 Vest Street, N e w Y o r k City 20. Institute, Dear M r . Strocp : I send you herewith an account of expenditures made during the first quarter of 1949 in pursuit of the A.P.I. project. From this information you will recognize that I was correct in my s t a t e m e n t t h a t the funds on. hand at the f i r s t of the y e a r w o u l d h e amp l e f o r the p e r i o d e n d i n g J u n e p0, 1949 I am sure you and your associates would he pleased to know that our building program is completed for all practical purposes, and that we are n o w able to get things lined up so as to work in earnest. Within the next thirty days we shall he going forward on all of the fronts of cur projected w o r k for A.P.I. Cordially yours, . RAE ef C .C . D r . M c l v e r V o o d y Fnc. . ,c atvi . " Robert A. Eehoe, m. D. API 04865 ) # UNIVERSITY OP CINCINNATI KETTERING LABORATORY OP APPLIED PHYSIOLOGY ACCOUNT OP THE AMERICAN PETROLEUM INSTITUTE FOR THE FIRST QUARTER OF 1949 jiplES (Based on Proportion of Time Actually Spent on Project) Franeis Heyroth Frank Dutra Joseph Treon A. Wesley Horton Dan Duvall Tom Gahegan Ruth Telger George N^dderman Wm. Poynter - Chemical and Toxicological Asst. - Pathological Assistance - Chemical Assistance - Chemical Assistance - Technical Assistance - " " - " " - " " - " " its c e l l a n e o u s EXPENSE Purchase of Animals Laboratory Supplies?................................. Traveling Expense ................................... Proportion of Secretarial, Library, Janitors, Wash Eoys, Draftsman, Shipping Clerks, Animal Care takers, Histopathological Preparation etc . . . . proportion of Heat, Gas, Electricity, Steam, Gas, Telephone, Maintenance, Pensions, Annuities etc . 425.66 27.87 II5.90 1800.0G 187.05 85.87 27.51 24.18 108.59 2802.43 6 3 .OO 945.89 907.70 765.19 41 l 6375.15 Balance Remaining at End of 1948 for vork in 1949 ...........................$22,597-98 Expenditures 1st Quarter 1949 ........... 6>57513 Balance Remaining for Work in 19^9 . . . . 16,222.85 API 04866  Ama 30, 19*9 Sr. Bofeart A. Satana Kattarlag Lataoratory af Affilai Ryaiolcy Calla af IMlala TtalTaraity ef rtaat-- Il Cincinnati 19, ohi f Jan 90 a i ttaa aaaoaat af a partii tanca atleta aaona to confini yonr a a rlla r ottanta tfaat thar 111 to b TfaniUd t o l w i i 1 ttaa f a i n t ttaa Qtoliaralty of ciaoicn att catme 30, 19*9 * $7,698 or a ra . a t t a la ttao lata acaaliar.tta a I to r aafiaa of ttaa ip o a M t bara taaoa alenai tay ttaa Precidaci art. Sacra ta ry a i ara aotoalttaA far MBUtowi a i murimi oa taotaalf of tfc UttToralty of C lao lan att. 7 a ataaak la *9,*13 WS ti oc: ftrA* lt Im i Sr. Salvar sooiy API 04867  A merican P etroleum Institute 9 0 WEST BOTH STREET N E W YORK 20, N. Y. June 3 0 , 19^9 Board of Directors tfaiversity of Cincinnati Cincinnati 9, Ohio Gentleaen: This cconunlcation la authority to continue work and to expand the scope of inreatlgatlan of the toxicity and node of action of curtain petroleum products for the year ending June 30, 1950 according to the t e n s of the agreement dated January 8, 1 9 k6 and on the Basis of a naTlmnn budget for operating expenses of $98,825 which Is conditioned upon an unexpended balance of $7,858 or sure regaining in the fund at the University of Cincinnati as of June 3, 19^9. Upon receipt of your approval of the continuation and expansion of the project with this conditional budget we shall pay you the sun of $b9,hl3, the balance of $b9,kl2, less the unexpended balance of $7,858 or acre, to be paid on January 1, 1950* It Is understood that any balance remaining In the fund on June 30, 1950 will be returned to the American Petroleum Institute, and that no excess over the amount of the budget Is to be obligated or spent without written authorisation. Tory truly yours, API 04868 m U N IV ER SIT Y O F CINCINNATI C O LLEG E O P M EDICIN E C IN CIN N A TI 1 9 , OHIO LABORATORY o f a f f u s o f m y b io l o c y CABLE AODRCSSi ICXTLAB, CINCINNATI I,'sv Y o r k C i t y . D e a r M r . 5':: o c p : TlrLs is to a c k n o w l e d g e y o u r lette: oi J u n e yJ w i t h t he e n c l o s e d copies, oi the c o ntinuation a g r e e m e n t . The latter have been f o r w a r d e d to the U n i v e r s i t y , w i t h o u r r e c o m m e n d a t i o n f'or their approval, and in due course the two executed copies requested will be returned to you. Sincerely yours, Hooert Eenoe, M. L RAK ef C .C : D r .i E . H o a g Mr. Lacey Walker Dr. Mclver Woody API 04869 a U N IV E R SIT Y O F CINCINNATI CO LLEG E O F M EDICIN E CIN CIN N A TI I , OH IO ^ si'`T0"r0F`wutD,HT"OL06T July 12, 1949 CABLE ADDREEIi KETLAE. CINCINNATI TELEPHONE) UNlVtaaiTV l i t i Mr. D. V. Stroop, Director, Department of Safety, American Petroleum Institute, 5'j Vest 5uth Street, New York City 20. Dear Mr. Stroop: In accordance with Dr. Kehoe*s letter of July 6 I am forwarding to you herewith two executed copies of the letter of June JO, extending the agreement between American Petroleum Institute and the University of Cincinnati to June JO, 1950. Very truly yours, ef C.C D r . A . E . Hoag Mr. Lacey Walker D r . Mclver Woody E. . / p o r t l a g S e c r e t a r y to D r . Kehoe * Enc. API 04870 ^TVONT of Ikdustfiax. Hyoiini ii;$>..~*v * HARVARD UNIVERSITY SCHOOL OF PUBLIC H EALTH July 12, 19li9 Mr. D. V. Stroop American Petroleum Institute 50 Test 50th Street. New York City Dear Mr. Stroop: Referring to ay request that you pay the bill for killing the type of the Cutting Oil Review, we' can take this out of our budget and get a refund later,'as .you suggest. If you wish to do so, please send copies ef this4letter, (extras are enclosed) to Dr. Hoag and his oomnittee Bashers, advise me accordingly, and we'll call the matter elesed. > r,., ... AC x Mr. Krista*has bee&MU'-aad that is why the paper was not revised as agreed^pem^Xt^willj9e;dsne .presently. - . .V' .' ,-- *,44* 7 * D A Simeerely yours, y PDjsl r .r&jtm* m Ene. . -A .&4*n& . >* - * ' %hb\ A*:-* IkiSip . '.`.fA.V' ~V ** * -f - i w. ie tPPSP Vr-r8* t API 04871 J W 12, Dr. Philip Erlaksr tortard Unir*raitgr Solcai f Patitile Saalth 55 S3m ttm k streat Boataa 15 Mm . Daar Bootar mator! Oda la la repljr te paar lattar of Juaa 30 ani reaelta fra aj lattar of rftr 6 tea Bootar leu, a aofy of aioA a aaat te jem. Seatar Bea eaggasta Uat 1 retare tto lerolee to 70 ltk reteeat tfeet lt to peid frae year curroot fseda tth tto wiirafll^ tfcet tto Bato ocamlttea m . Panaiaaitla Ccaoeatretlooa aaoald rofnaat e n irraapnrtHii latrataa la th aaxt errat te to reeaaaaadai. far H aeri, a eatllaad la Ito aacoud altaraetlro atetad la 9 lattar ef M ; 6. Tto larolaa la gatarati toravlth. a treat ttot ttia proatiart 111 to fmtj truly yr , DTB:d sa: ] . C. Baivi J. V. tolt k, I. toa l. 1. Barae API 04872  SO C O N Y - V A C U U M O I L incorporated COMPANY s t i, ia i. r e l a t io n ^ H. m o n t o o m i r y 2(5 Broadw ay, A'ew Y o rk 4, N. Y. Mr. D. V. Stroop American Petroleum Institute 50 West 50th Street New York 20, H. Y. July 11, 1949 Rei "The Cutting Oil Dermatoses A Critical Review" by 6. C. Xriete Dear Mr. Stroopj Your oonmunioation of July 6, 1949 has been received and considerad. In my opinion, I would suggest that Method #2 be carried out. It would be such less expensive and would save a great deal of time. Method 4 Z i "Request Dr. Drinker to pay invoice from his current funds and request Medical Ad visory Comoittee at its next meeting to reoaasaend corresponding increase in payment to be made to Harvard on March 14, 1950 from $10,000 to $10,139.61 for the next fisoal year." Very truly yours. AEHsDHM API 04873 I I Br. a . X. Soeg ' Soeocy-Xacnaa 011 Ceopeay, Sh . I ; I26nBrToaardkeaky, I.T. I Saar Doctor Sooft ly 6, 15*9 ' Xcr yoor eonallwotlc aad edrio# I emlinee ooyjr I of lcttcr lata! Jvm 30 trtm Doctor Ihlllp Brlokar Ith thloh ho eest so ob laveloe Io. 17311 Area S VIUIh h a* VUklao Ccrpaay, Baltimore, Merylaod, aaoaattno to $139,61 to eoaar "her* for kllllag ortiolc 'The Cvttlas 011 Paraatoece - A Critioal Partee' ^ hjr l. c. irieta." ^ I fiad. ^aalf aoahlo to pay tfcla latele# ao oar | expaalltaraa oro 1 M W to Moto n o w r t i l ty the Medical Aldoralrede9ryt Coaalttae and Pircotaro. iq rw l ty tho afety CoMlttoo cf tho ^4. OolTcrdty lo SoSvaMohe1r1119r*c7cotlolrolboOthci$.2c,c30t0hetAoPIjafinddtothMoerrocatardt I eoeto io the praperetlhi of tho rorlev. M a r tho lothnr otrlct rolee mraiag ear hoadlliH of epedel tmia, tkU aottar aey he handlad lm elthar of too ayo, ao falloca i 1 1. f w the Medical Adrtacry Cceotfttea ty lotter * tallot eo fajoeort of $1391 lamloe aoA aeowe 1 ijfricol freo the Baftty CcMdttoo cf the eerd ly a eoonad lotter teilet. t. lofBoet Booter SrlMhv to pay lerdee frac hie CcHBlttoo at lto aezt aeortag to reccHeeod BrwT1j2r2,Tr*1950 SaTSoooVo * $10,139.61 ihr the aext flaoal paar. PVSid ec: lot T. C. Salrd Philip Briol J. P. Seit 1. 1. Paare of aetloo jea *7 tmly Jtsare, API 04874 otPaTM^"ro f I n d u s t s ia l H y g i e n e . ^ HARVARD UNIVERSITY SCHOOL OF PUBLIC HEALTH 55 Shattucl{ Street `'Boston 75, ^..Massachusetts Mr. _ V. o uI*C*0^ American Petroleum Institute 0 V.-est oGth Street :;-5vr Ycr.< Sit;/ lear Mr. Streep: Herewith till ter pljP.ul tor 'iliing the article or -- "'r' Jis as car vote of API Medical C o m i t t e e at ,,etrotu last trrii. You will remember Chat the paper actually was 1 salley e r e c t , having seen approved by the committee, then ap treval was withd r a w n and we were stuck w i t h tne ccst of p r m ina the galleys. 1 do not think it woulo ce tair to or.arge this arainst our own special bueget. Please advise. PI: s i i.nc. 04875 API JfcOj 15 , 19*9 Er. Bobart a. t abac .Tattering lAantw7 of Applied rbjalelocj Colisas ef Modici Beltcnltp of Classanti Claolantl Chle Door Doetor tabea: Ibis la to aetitoel**# racci.pt of tbs toe MBMvtad copies ef tbo acntlamtlae sgresisn t of Swam 30, 19*9 ad. to -- ! tbo Inatltuta' cesaci in the want of i*9,*13 m aaeardono* with tbe taras ef tba sjri-- nt. Try trnlj je a n , TBtd oc: Br A I I n i Sr. Hilter Haodj API 04876 U N IV ER SITY O F CINCINNATI C O LLEG E O F M EDICIN E C IN CIN N A TI 1 . OHIO July 18, 1949 CABLE A D D A M I: K ETLAB. CINCINNATI TELEPHONE: UNiv im it y M SB Mr. D. V. Stroop, American Petroleum Institute, 50 Vest 50th Street, New York City 20. '/< v ' \ Dear Mr. Stroop: I herevlth acknowledge with thanks receipt of American Petroleum Institute's check In the amount of $49,413.00, covering expendi tures to be made on their b e h a l f . Very truly yours E. R. F o r t l a e , S e c r e t a r y to D r . Kehoe ef API 04877 f 0 < U N IV ER SIT Y O F CINCINNATI C O LLEG E O F M EDICIN E CIN CIN N A TI 1 9 , OHIO p*0l a b o r a t o r y o p a p p l i e d p h y s i o l o g y S e p t e m b e r 1, 1 ^ 4 9 C A S L I A DD RESS) K IT L A S. CINCINNATI TELEPHO NE) UNlV Mr. D. V- S t r o o p , The American Petroleum Institute, ' 5 j West 5uth S t r e e t , N e w Y o r k City 2u. Dear M r . Strocp : I send you here w i t h an account of the expenditures made on b e h a l f of the A . F.I. p r o j e c t f o r the s e c o n d q u a r t e r of 19^9- Very truly yours, ef Enc E. R. F o r t l a g e / S e c r e t a r y to D r . Kehoe API 04878 6 UNIVERSITY OF CINCINNATI KETTERING LABORATORY ACCOUNT OF THE AMERICAN PETROLEUM INSTITUTE FOR THE SECOND QUARTER OF 1949 jS (Based on Proportion of Time Actually Spent on Project) Francis Heyroth Wesley Horton pan Duvall Vim. Poynter Earl Korpi Sylvan Witherup Chemical and Toxicological Cheihlcal Assistance Technical Assistance ii ii it it Asst, sc.Cf.T.TANEOUS E X P E N S E purchase of Animals Laboratory Supplies Traveling Expense . proportion of Secretarial, Library, Janitors, Wash Boys, Draftsman, Shipping Clerks, Animal Caretakers, Histopathological Preparation etc ........................ Proportion of Heat, Gas, Electricity, Steam, Gas, Telephone, Maintenance, Pensions, Annuities etc . . 155.43 1800.00 28.85 58.74 113.24 10.77 2145.08 5774.24 Balance Remaining for Work in 1949 at End of First Quarter 1949 ............... $16,222.85 Expenditures Second Quarter 1949 ............... 5,774.24 Balance Remaining for Work in 1949 ............. Receipts - July 18, 1949 ............... $10,448.61 49,415.00 Total Balance Remaining for Work in 1949 at End of Second Quarter 1949 ............. $59,861.61 API 04879 i October 19, 19^9 Dr. M c T w Voodj ^aeo Standard Oil Canpeoy 1? Vast Jlst Street ftn York 19. I.Y. rear Doctor VeoCjt Tar joar laforaetloa wa enclose copy of "budget data supplied to as by Doctor Eh,:>c vlth his letter dated October lktk. T.-ry truly ycurr, DTS:d Snclosore API 04880 October 19, 19*9 Ir. Bobart A. Xaboa Uaireraitjr af Cincinnati B u lottarla labarotory Colica of Madida CloeIssati 19, o d o Ior Doctor lobo#: Tteslr jou iwrj weaoh far your lottar of Ostobar 1* ad tba tao eoplaa of tha aatlaatad bodgot on tba API earoljx>9ralolty jrojaet far ttao flseal yaar 1950-51. tary truly 7w*ra, DfB:d API 04881 , iJTTEAlN LARORATOR * \ . e t Of MEDICINE-- EDEN AVENUE Sill 0H` UNIVERSITY OF CINCINNATI DEPARTMENT OF PREVENTIVE MEDICINE AND INDUSTRIAL HEALTH October1 14 , 1 CANLE ADDRESS; KTTLAS. CINCINNATI TELEFHONE; CAPITOL U I4 Mr. D. V. S:r*oop, Lire .-xierican P e t r o l e u m 50 Vest 5 < jth Street, Lev York City 2j . Institute, Dear M r . Strocp: I a m s e n d i n g y o u h e r e w i t h t a b u l a t e d i n f o r m a t i o n in r e s p o n s e to your request for it in connection w i t h preparing the budget of your organization, in connection with our work, for consideration at the November meeting. This information may or may not be in the form in which you will w i s h to m a k e use of it, b u t it w i l l serve, I b e l i e v e , to a c quaint yo u w i t h the outlook so far as we can see it. If there is any other information you require, do not hesitate to let me know. Sincerely yours, F.AK ef 'feu R o b e r t A . K e h o e , >1. D . Enc. API 04882 <) BUDGET DATA FOR AMERICAN PETROLEUM INSTITUTE Investigation of Cutaneous Carcinogenic Materials by Kettering Laboratory Schedule I Program vith on behalf of respect A.P.I., to Petroleum Technology and Epidemiology, (excluding testing of materials by means of mice) Compensation for Personnel Supervision July 1949 Estimated April 1949 to July 1950 Estimated * October 1949 $ 2,500.00 $ 2,50u.00 July 1^50 to J u l y I 95I Estimated October 1949 $ 2 , 5 o 0 .j principals - Petroleum Technician Epidemiologist Assistant Chemists Travel 7,200.00 5,ooo.oo 4,800.00 7,500.00 . 7,20 0 . Ou 2,500.00 7,200.00** 5,ooo.oo Special equipment Laboratory supplies - , - ' 7,500.00** 5,500.00 Overhead ~ "'T5'.T00 .'00 ' ' 1 7 , 7 0 0 i00 TOTALS 40, 500.00 j 5 5 , 1 0 0 . 0 0 7,2u0.ju 5 , 0 0 j .00 8 ,8 0 u .00 5 , 0 0 0 . 0 0 - 5,500.00 16,000.00 48, 000.00 f- -, * Based on f igure_..oaple_te_j)r .largely complete to October 1, 1 949 ** Represents part'of year compensation for tvo assistants ** Represents allocation of cost (50) of infra-red spectrograph, to the project API 04883 BUDGET DATA FOR AMERICAN PETROLEUM INSTITUTE Investigation of Cutaneous Carcinogenic Materials by Kettering Laboratory Schedule II Program v l t h respect to Testing of Materials by means of m i c e , on behalf of Petroleum Industry Supervision pathologists path-technlclans Animals ^ 2 ,500,00 ' 7 /2OO.OO 5 ,000Ou 10 ,000.00 Technicians (animal tests) . 7 ,200.00 Record Clerk . ..2,4.00.00 Anim a l C a r e t a k e r s (2). 4,000.00 Special equipment (Cages, etc>) Supplies Overhead TOTALS 7 ,500.00. ' V .4 *' 'u n . .23,650.00 ; TO,950.00 Estimate of Cost Born b y Others '" Estimate of Cost for A.P. 1.70,950.00 * ` - '.'-ir A. "*- $ 2 ,500.00 7 ,200.00 3 ,000.00 2 ,500.00 $ 2 ,500.00 7 ,200.00 4,COO.Oj 3 ,500.00 4,980.00 2,400.00 . 3 ,000.00 . 5 ,200.0j 2,o0u .00 4,000.00 5 ,276.00 3 ,500.00 1 7 ,178.00 51,554.00 - 3 ,500.00 16,250.00 48,750.00 10 ,307.00 ` 41,227.00 4,875-00 43.875.0o API 04884 - B U D G E T D A T A FOI. A M E R I C A N P E T R O L E U M I N S T I T U T E Investigation of Cutaneous Carcinogenic Materials by " Kettering Laboratory summation of Schedules _I and II Est i m a t e d Cost of Entire P r o g r a m for A . P . I J u l y 1. 1949 to July 1, 1950 Estimated Estimated April 1949 October 1949 $40,500.00 $ 5 5 ,100.00 70.950.00 41,227.00 J u l y 1, 195^ to J u l y 1, 1951 Estimated October 194 9 $ 48,000.00 43,875.u 0 TOTALS - Schedules I and II 111.450.00 Balance on hand July 1949 Estimated Requirement to Ju ly 1950 94,327.00* 59,861.61 34,465.-22_____ 91.875.0J 70 j^ritso gg, fAPfOZ- ftj 0 0 VJ 04885 API n-rfr- kttart Thbb^ Indot of AUTOMATIC 1BJEGRAPH *flh message feeing outwrd *^St: _..._,__, . " -.%; *A WUENSTIOERNN JOSEPH L. EGAN PKCSiDINT C M A M I TO TMB AOCOOMT OF 50 IBEGMFH^ pUcMObMMi^ ancHm^WK k onftcw*$ ' ,"?*rue v.; An T * J**- fcSEWRITEOR TYPEMESSAGE PLAINLYWITHIN THE BORDB?--USE BUCK INK OR I API 04886 For Information Only - Wot For Publication Report to Subcommittee on Carcinogenicity of the API Medical Advisory Committee on PROJECT CN CARCINOGENICITY AT THE UNIVERSITY OF CINCINNATI 4 \\y The following discussion will be restricted to the technical aspects of the project- Doctor J. J. P.iair will attend the meeting in Chicago, November 10, 19^9, and will describe at that time his tentative plans for an epidemiological study of actual cancer cases in the petroleum industry. To date, process data on the various cracking and lube refining processes have been received from about sixty per cent of the cooperating oil companies. In line with the recommendations of the API Subcommittee in their meeting February 1, 19^9> the samples listed in Table 1 have been requested and are, at this time, either under test on experimental animalB or pending investigation. Samples of various cokes and heavy coker gas oils will be requested in the near future. Operating data on the various catalytic processes, not included in Table 1, are not yet sufficiently complete to permit any logical selection of samples. Of the "specific products" recommended for study, particular attention has been given thus far to the solvent extracts (Samples API-lU through IT) of certain lube distillates. Since these extracts should contain the major portion of any carcinogenic components of the original raw lube stocks, it is felt that testing of the latter can well be postponed until the results of the tests on the extracts are known. Further selection of samples will proceed cautiously until the survey of the cracking and lube refining operatlone covers at least eighty per cent of the oil companies. When that situation obtains, a list of approximately 100 to 150 samples from the various processes will be drawn up. This list will then be submitted to the Subcommittee for review before going ahead with the full scale testing program. To conclude this discussion of samples from typical refinery streams, we should like to offer for consideration the following sugges tion. It is felt that the data thus far obtained definitely rule out any possibility of the use of boiling point alone as a sufficient criterion for determining the dilution of a carcinogenic oil necessary to permit safe handling. A single case might be cited. A typical heavy catalytically cracked oil, containing lees than ten per cent of material boiling over 700 F., has been tested on mice in the usual manner. Half of the animals given adequate exposure developed tumors, most of which were found to be malignant on postmortem examination. Hence it is urged that as much atten tion be given to the concentration of the aromatic component of an oil as to itB boiling range in considering any formal recommendations on dilution. kPl 04887 -2- The experiments previously mentioned, in which various concen trations of a standard carcinogenic hydrocarbon, Methylcholanthrene, in benzene are being tested, have proceeded very satisfactorily. The results will be presented graphically at the Chicago meeting. It has been found that with the C3H strain of mice, used in testing the first 8 oils, that the concentration of methylcholanthrene is inversely proportional to the times of appearance of tumors in the different groups of mice. Thus, with the C3H strain of mice the benzene solutions of this carcinogen offer an excellent set of standards for reporting the relative carcinogenicities of the oils to be tested. Simultaneous experiments with a CFW strain from the Carworth Farms have brought out interesting differences in the effects of the polycyclic aromatic structure on mice. Based on time of appearance of tumors, this strain is more susceptible to the lover concentraions of methylcholanthrene (below 0.2 per cent) than is the C3H strain. Hence the CFW strain may be useful in accelerating the determination of relative potencies of the oils which are only mildly carcinogenic. However, perhaps due to some general toxicity of high concentrations of methylcholanthrene for this particular strain of mice, there is no further shortening of the induction period with concentrations higher than 0 .2 per cent. The technical personnel required to handle adequately the work of the carcinogenicity project are now assembled. The predicted expansion of the animal testing program may require an addition of one non-technical assistant. The group handling the actual testing of oils on the mice remains essentially the same as previously reported, with the addition on July 1st of Dorothy A. Templeton, B.S., who is responsible for keeping the records of the animals and for bio-statistical studies. Pathological examinations of sections are being made by Frank P. Cleveland, M.D., and Frederic Shaffer, M.S., under the general supervision of Frank B. Dutra, M.D. By July 1, 1950, the animal testing program will be amplified considerably, involving about 6 ,0 0 0 mice required to test between 1 5 0 to 200 samples drawn from typical refinery streams. Further developments in the direction of an analytical tool based on the physical properties of the streams should aid in the selection of the samples. Further experiments are contemplated using standard carcinogenic hydrocarbons, such as Methyl cholanthrene and 9 >10-Dimethyl-1,2-Benzanthracene, in both a non-volatile solvent, dodecylbenzene, and in some solvent of very high viscosity to stimulate thermal tars. Experiments which have already been started involving washing animals with soap solutions at definite periods after application of a carcinogenic catalytically cracked oil will be continued and expanded. These tests have not been running long enough yet to permit more than a statement that the normal time of appearance of tumors has been delayed by washing. Lastly, mention should be made of the fractionation studies being carried out in our chemical laboratory. Bussell Tye, M.S., has been engaged in this work with the Laboratory since July 1st, and on October 3rd, Euth C. Pierle, Ph.D., Joined the group. Much of the work has been With Oil v - 3 6 3 2 (API-8 ), and with another FCCU decanted oil, API-12, which is a somewhat cleaner product to work with and about equally carcinogenic API 04888 f * -3- to mice. Progress tovards the development of a rapid analytical tool, which might he applied to any refinery stream to determine its carcino genicity, has been very satisfactory. The technique is, at present, being applied to all of the oils which have been previously tested for the American Petroleum Institute or for individual oil companies. Details of the method and results of its application to the various oils will be discussed at the Subcommittee meeting, November 10th. October 25, 19^9 A. Wesley Horton (I II-2-U9 kpl 04889 1> TABLE 1 "API Sample Humber 9 10 11 12 13 lk 15 16 17 18 19 Process TCC TCC HoucLry FCC Product Syn. Tower Bottoms Fuel Oil Syn. Tower Bottoms Decanted Oil Gravity 18.k 11.6 L.3 18.1 Polyforming Polyformer 9-7 Tar Solvent Extrac- Extract from 10.3 tlon (Furfural) Kansas 200 Stock Solvent Extraction (Furfural) Extract from Okla. crude (for LOO Pale) Solvent Extraction (Phenol) Extract from 900-X Coastal Distillate Solvent Extraction (Duosol) Extract from Calif. Waxy Residuum Viscosity Breaking of API 17 and San Joaquin Asphalt Cracked Residuum Naphtha Reforming Reformer Tar 10.9 11.0 7-0 6.0 17.0 Wax Pressing FCC Slack Wax from Lima Crude Heavy Cycle Gee Oil 26.1 Thermal Cracking (DeFlorez) of FCC Heavy Cycle Gas Oil above Thermal Tar 13.5 Boiling Range 1*25 756 F. 550-92$ at 760 l*38-8l$ at 700 L35-7L* at 750 LL0-75$ at 7L00 705-9200 720-95$ at 980 790-50$ at 915 650-50$ at 950 355-9*+$ at 706 1*27-828 373-95$ at 1050 UOP "K" Factor 10.7 (70$ aromatics by silica gel) 10.7 9.8 11.3 (50$ aromatics by silica gel) 10.1* 10.8 11.1 11.0 10.2 11.6 10.9 API 04890 COPY Mr. D. V. S t r o o n October 31, 1949 (air sail special delivery) Dr. Mclver Woody, Medical Director, ESSO Standard Oil Company 15 West 51st Street, Hew York 19, . I. Dear Doctor Woody: We have again reviewed the interin progress report submitted to- you last week. Since none of the samples at present under test are far enough along to per mit any definite conclusion f & t r d l n g their physiological activityr it ia felt that nothing more could he said about that pfcirae of tha: program. .-Aa indicated in' paragraph 4 of the report, eur plena for.animal tests of such materials in 194& are necessarily on a..tentative basis. Ve have reason to expect thet we.shall probably have SO per cent of the eompaniea represented on eur data sheets within the next two months. Our full seals testing program on refinery samples for 1950 can then be organised and submitted to the Sub-Committee for review. Tha necessary equipment for the fractionation work is tha ekemiedl laboratory v m not available until about July 1st. S u m e r vaeatloa*postponed active initiation of these studies untilriuguet* ,,Hepce 2 am.not unpleasantly surprised bo 1fled-myself-in e.position to.discuss even in a preliminary.manner data which we.believe will lead to a use ful analytical tool in. the determination of the carcinogenicity of petroleum products. . . ' Thus, while many aspects of the project, plans for which hare beenpreviouely reparted to the Sub-Committee, have recently gotten under way it is felt that the results of the present stage of the work hardly warrant any formal and lengthy discussion. PI 04891 Dr. Mclver Woody 2 October 31 1949 To couplet the discussion of current work, I am adding the following paragraph to the report (to appear on Page 3 just preceding the final paragraph): By July 1, 1950. the animal testing program will be amplified considerably, involving about 6.000 mice required to teat between 150 to 200 samples drawn from typical refinery streams. Further developments in the direction of an analytical tool based on the physical properties of the streams should aid in the selection of the- samples. Further experiments are contemplated using standard carcinogenio hydrocarbons, such as Methylobolanthrene and 9,10-Dimethy1-1.2-Bensenthracene, in both a non-volatile solvent, dodecylbensene, and in some solvent of very high visoosity to simulate thermal tars. experiment whioh have already been started involving washing animals with soap solutions at definite periods after application of a carcinogenic catalytically cracked oil will be continued and expanded. These tests have not been running long enough yet to permit more than a statement that the normal time of appearance of tumors hes been delayed by washing. Since receiving your letter of October 21st in which you Indicated your concurrence in the idea that the members of the Sub-Committee should be given an opportunity to review this progress report before the meeting, I have talked with some of the members personally. All have been quite pleased to tamer that they would receive the report in advance. Hence, with the inclusion of the preceding paragraph, 1 hope that you will find the report which you have in hand suitable for distribution. I can assure you that the technical aspects of our work are covered completely therein and could in no sense be rendered confusing by any thing I plan to say on lovember 10th. The graphs which I API 04892 Dr. Mclver Woody - 3- October 31, 1949 shall bring to the meeting show only the preliminary results of the methylcholanthrene experiments, which are by no means complete as yet and include no microscopic examinations. You will recall that last Wednesday we discussed the choice between lantern slides and photostats. Since we were in agreement that the incomplete nature of the experiments did not warrant a permanent record, I shall present the data we have on slides as suggested. I believe that the members of the Medical Advisory Committee would have a much better opportunity to talk over the program with their technical associates and prepare their suggestions concerning future work if they did receive this material prior to the Chicago meeting. However, if you wish, 1 shall have the report mimeographed here to be handed out November 10th. If this is your desire, please advise me by Friday, November 4th, so that our secretary will have time to do the work before I leave Cincinnati: on November 8th. Sincerely yours, V mt A. Lesley tforton AWH:fe '* ' v/cc: Kfa D. . Stroop. PROJECT OK CaRCIKOGEKICITT *T THE UHIVERoITI OF CIKCIKMATI Tbs fellova dio euaalon will bo rotriotod to the tookaleal aopooto of tba proJot. Doctor J. J. Phtir v l U ottood the aeating la Chicago, November 10, 1949, aad via describe at that tlao bit tentative plaas for aa epidemiological study of aotual eaaeor eaooa la tbo petroleum industry* To dato, proeoaa data on tha various racking and H lubo roflalag prooaaaoa have boon received froa about sixty par at of tba cooperating oil eoapanisa In lino vith tba reeonaeadatlons of tba API Sub-Coaaittaa In tbalr aooting February 1, 1949, the aaaplaa llatad in Table 1 hata boon requested and are, at thia tlae, either under beat on experimental .aalaalt or ponding Investigation. Staples of various cokes aad heavy okor gas olla vill bo requested,in theaeer futura Operating data on the varioua catalytic.nrofobaoa. not lacludedla Tabla 1, ara not yv uffjLsiegily-eoaplat to permit any logleal aeleation of aaaplaa * of the *apacific products" raseaufaded .for atudy,->partlaular attention"baa boon givoa tbua far.te tho-solvent extracta (Samples kt1-14 tbrougk 171 of trtala.lubddistillate. Since these extracts should contain' :iba.major portion qf any carci negoala coape&atn pf the original rav lube stocks, it II is felt that toftlag of the"latter aa veil bo postponed uatll^tbo.fftfulte oJfap|>ete on tbe extracta aro kaovn. r - , ' y g tfr ** ' T * r , t r r* * y ,. ~ \ ' -Turtber aeietion-f oeaales vill proceed cautiously until iba frryveftb tracklag aad lubo refining opera- tiobfecovert at yteag$ SO per cent of tba all eoapaalas Vhet^ltet situationjohtaas, a list of'approximately lOCLtftl50 aaaplaa froa the various processes vill ba dravnjup This list gill.tbaa,ba aubaittad to tbo Sub- Coaouttoo for review`before^gglag aheadjdth tbo full saalo toating program" API 04894 To eoneludo this dieousdon of ssaplos fro typical refinery strcas, wo ahoaid like to offer for consideration the following suggestion. It is felt that the data thus far obtained definitely rule out any possibility of the use of boiling point alone as a sufficient criterion for dotorainlng tho dilution of a carcinogenic oil necessary to parat safe handling, A single ease night be cited. A typical hoary eatalytleally cracked oil, containing less than 10 per cent of aaterlal boiling over 700* F., has boon tested on ice in the usual anner. Half of tho aalaals given adequate exposure developed tuners, nost of which yere found to b# alignant on postaorta cxaaiaatlon. Hence it is urged that as uch attention bo given to the concen tration of tho arenatic component of an oil as to its boiling range in considering any foraal reoonnendatione on dilution. Tho experiasatn previously nentiened, in whleh various concentration of a standard earelnogenls hydrosarhon, Kethylebelaathrene.-in Pensons are hting tested, have preoesdsd vary satisfactorily. The results will bs pre sented graphically atthe Chicage cctlng. It has been found that with tho O f strain of nice, need in testing ths first I oils that ths concentration of othyleholanthrono la inversely proportional to tho tines of appearance of tuners in the different groupe of lot. Thao, with tho C3I strain of aioo tho boasoao aolutiona of this oarciaogon offer amaxcellastsctof standsrda for resorting tho rolatlvo tareiaogonisfttios ef tho eils to be tested. ilaiitauoilsenthaMie with a CTV Strain fro the Carwerth Fana have ereughcoet internatimg dlffereneee in the offseta of tho polyeyolle aroaatlc atruoture on nice. Baaod on tliM of appoaranoe of tuaore, this strain is aore susceptible to tho lower concentrations of aethylcholanthrone (below 0.2 per cent) than is the C3H strain. Hence the CFV strain nay bn. uanful. Iil.accelerating the determination of rolatlvo patencies of the oila which era only aiIdly eareinogonie. However, perhaps due to aoaa eneral toxicity of high concentrations of asthyleholanthreno for this partioular atrain of aico, there is no further 04895 hVT- API, S*pl* jitinbT, Process Product Gravity Boiling Bangs UOP I" Factor 10 11 12 13 14 15 16 17 1ft 19 - TCC TCC Houdry FCC Syn. Tower Bottoms Fuel Oil Syn.Tower Bottoms Decanted Oil lft.4 11.6 4.3 1ft. 1 Polyforming Polyfoaer 9.7 Tar * Solvent Extraction (Farfmal) Extract from Kansas 200 Stock 10.3 Solvent r rEmnraetiea (Minral) Solvent Extraction (Phenol) T Sntmct ttvm isr* Okla.erwdo ' (*400 Pale) ' ' lartraet from 900-1 Coastal Distillate n.ft Solvent Extraction (Duosol) Extract from 7.0 Calif. haxy Besiduum Tlaeouilty Cracked 6.0 Breaking of Besiduum API 17 and San Joaquin Asphalt aphtha Boforaing Beforaer Tar 17.0 Wax Pressing Slack Wax from Lima Crude FCC Heavy Cycle 26.1 Gas Oil Thermal Cracking Thermal Tar (BeFlores) of FCC Heavy Cycle Gas Oil above) 13.5 425 756 F. 550-92* at 760* 43ft-ftl* at 700* 435-74* at 750 440-75* at 740* 705-920 10.7 (70* aromatics by silica gel 10.7 9.ft (50> aromatic* by silica gel 10.4 10. ft 720-95* at 9ft0* 790-50* at 915* 650-50* at 950* 11.1 11.0 355-94* at 706* 10.2 427-S2* 373-95* at 1050* 11.6 10.9 API 04896 Esso Standard Oil Company M edical Departm ent E s 9 o B u ild in g . 15 w e s t 51s t S t r e e t . New Y o rk 19. N. Y . T H O M A S G. E L I A S . M. D. CLINICIAN C L Y D E M. B E R R Y . PH . D. 1N D D IT K 1A L B Y O IB K 1 B T HAAil fltfi Horaahar 1, 19^*9 Dr. A. Vlay Horion Dninuralty of Cicerinati Eapartaant of ^Tarantina Hadiein* and Indatrial laalth Cincinnati 19 Ohio Demr Dr. Horton* 6 * n *a *T la r faar lattar of y*t#rday, X cannait*d Dr. Hn*c and Hr. Staroap, hath af ahoa ana alta villini to ha guidad hy yonr daira to ban* year pragraa* ranort circnlatad orior to the Mating. In line with your raguaat, tjh* addi tianaL paragraph *>y July 1 , 1950 ... dalayad by vathing". vili ha iraartad Just W f o r * tha concluding naragraoh of your ranort. liscmiy, XelViXH ee Hr. 2.T. Stroop API 04897 October 25, 19^9 Dr. Mclver Woody, ESSO Standard Oil Co., 15 Vest 51t S t . , New York 19, N. X. Dear Doctor Woody: I an attaching the promised report for distribution to menberB of the API Medical Advisory Committee prior to the Chicago Meeting. I an looking forward to seeing you on Thursday or Friday. I shall telephone you when I arrive in town to arrange a suitable tine for a neeting. Sincerely yours, : . . A. Wesley Horten AH:fe end. _ cc: .Dr. A. E. Hoag, vMr. D. T. Stroop with attacbaent-s. API 04898 c s I CONFIDENTIAL O For Information Only - Not For Publication AMERICAN PETROLEUM INSTITUTE SUBCOMMITTEE ON CARCINOGENICITY \N < Members Present Minutes of Meeting November 10, 19^9 Stevens Hotel Chicago, Illinois Associates Present Marshall Clinton L. E. Curtis T. M. Frank T. J. Kelly M. N. Nevquist C. A. Svan Melver Woody L. C. Beard, Jr. A. E. Dooley B. W. Faulk H. G. M. Fischer H. P. Lankelaa Visitors W. 0. Armstrong F. F. Boys J. W. Crookshank Kieffer Davis A. E. Hoag E. K. Linder J. W. Long B. B. Beeve E. W. Adams C. T. Brown B. C. Cole N. J. Gothard L. M. Henderson C. A. Neilson B. M. Shepardson F. M. Watkins GuestB E. D. Bent - The Atlantic Befining Company R. E. Eckardt - Standard Oil Company (New Jersey) E. A. Evans - President, Institute of Petroleum, London A. W. Horton - University of Cincinnati W. J. McGill - Standard Oil Company (Indiana) B. C. Mlthoff - California Research Corporation J. J. Pbair - University of Cincinnati W. D. Seyfried - Humble Oil and Befining Company H. B. Warrick - Ihe Texas Company W. 0. Wilson - Standard Oil Company (Indiana) Advisor D. V. Stroop - American Petroleum Institute Total in Attendance - 39 Memberb Absent . J. P. Holt W. E. Levis K. G. Mackenzie API 04899 II -2- Nev members and guests were introduced. Minutes of the June 3> 19^9 interim meeting were approved. Dr. A. Vesley Horton. Assistant Professor of Industrial Hygiene, University of Cincinnati, reviewed briefly the progress report which wbb sent to the subcommittee members prior to the meeting. He said that data obtained so far indicate that the use of the boiling point alone is not a sufficient criterion for determining the dilution of a carcinogenic oil necessary to permit safe handling. The aromatic content must also be taken into account. Dr. Horton presented a series of lantern slides to show the progress being made at the University of Cincinnati toward developing an analytical tool. The technique is being applied to all oils which have been previously teBted on animals at Cincinnati. This predicted expansion of the animal testing program may require the addition of one or two non-technical assistants. Dr. J. J, Phair, Professor of Preventive Medicine, University of Cincinnati, in discussing the epidemiological aspects of this problem reported on the advantages and disadvantages of various approaches. He proposed the establishment of a cancer registry for the petroleum industry at the University of Cincinnati and submitted a preliminary form for recording data on cancer cases. He requested that the subcommittee members submit suggestions as to changes in the form and how it should be used. It was the consensus of the subcom&ittee that legal advice be obtained as to whether reporting such cancer cases to the University of Cincinnati would be an invasion of an individual's rights. Dr. Elliott A. Evans, President of the Institute of Petroleum, London, reported briefly on the cancer problem as it relates to the petroleum industry in England. He said that in England the chief interest was the problem of effects on users of petroleum products. He requested that the exchange of information between the API and his organization be continued. Those subcommittee members who had written articles on cancer for their company employee publications reported that such articles had caused no adverse results. The subcommittee recommended to the Medical Advisory Committee that: 1. Exchange of information between the API and the Institute of Petroleum, London, be continued as during the past year. 2. Legal advice be obtained as to whether an oil company has a right to report cases of cancer that occur among its employees to the University of Cincinnati. 3* Adequate funds be allocated to continue cancer research at the University of Cincinnati for the twelve months ending January 30, 1951. A. E. Dooley Secretary 11-28-U9 Mclver Woody. M.D. Chairman PI 04900 m'rni.y (2)Reported by: ) C A .W C O T B E F O B T ^on to See reverse fo r In stru ctio n s IL V'.tien a n d e t V i e a d a ' C in c in n a ti. 19, Oblo (3)Name: (6)Address Number Street : ().L)Born-Year: (7)Sex: MF (8)Race: 'JVC (^ C o u n t r y : Marital (9)Status: MSWD City: State: (lO)Social Security Number: CLINICAL Primary (ll)DIAGNOSIS: Pirat irrvisir _ (12) S i t e :_ Pira t ___________ ( 1 3 ) S t a g e : Pirat (17)T r e a t m e n t ! _______ (l 8 ) D e a t h : PATHOLOGIC (20) B i o p s y DIAGNOSIS: (19)Date: (21) Autopsy ( TREATMENT Surgery Radiation (23)ADVISED: X-Ray Other TPEATfT* (2.\)R E C E I V E D : Surgery X-Ray "Radiation Other (2e;)C O M P L I C A T I O N S : ADDITIONAL ' Discovered (27) by: Personal (2 9 ) phy3ician: Clinic or (30)Laboratory: Medical Private Department Physician Health Department Self in a (2d)| r o u tine! s p e c i a l | o t h e r | e x a m i n a t i o n Address : Address : (3 1 )Hospital (32)OCCUPATIONAL PROM TO RECORD: List EMPLOYER positions Address : chronologically beginning with ADDRESS PRODUCT last or present one JOB DESCRIPTION API 04901 r' "v,,: - . with FROM TO p o s s i b l e [t i g h t ' Carcingena m h m l i (3U)COMPANY: FROM TO Department DEGREE-Exp. ' fll7 . II.gt." TVP E-Exp. H Agent FROM Coni cc; IrCHROMATE Cnt. jcgr~fl AESEfrnr ConbT * ASBESTOS WORK m THE PETROLEUM INDUSTRY . ,, Jot d e s c r i p t i o n DEGREE-Exp. Hvy. ILgt. ~Hvy. T g T . flvy. L i t . TVPE-Exp. Cont\|cc". Cont. Occ. Cont. Occ. Products handled 1 " 1 ..... / p'ROM TO department % Job description Products handled jvPI 0 4 9 0 2 ..i in', i- -, --Vm i tM 1hi*i ir i J  MEMORANDUM I November 10, 191+9 SUBJECT: RECEIPTS. EXPENDITURES AND ALLOCATIONS -- API MEDICAL RESEARCH FUND Contributions Received 19**5 19V7 I9W 19^9 TOTAL $2 8 ,9 0 0 .0 0 27,800.00 98, 300.00 6k,3kO.OQ $219,31*0.00 Expenditures Made Prior to November 10, 19^9 Harvard University Toxicological Revievs Cutting Oil Study $37,000.00 2,500.00 39,500.00 University of Cincinnati Carcinogenicity Fluorine Study 120,1*13.00 5,000.00 125,U 3.00 Miscellaneous Books for Committee Use TOTAL EXPENDITURES BALANCE ON DEPOSIT 57.77 M .laji 5*,,369. 23 Payments Required to Continue Current Projects Unit! 6-30-50 Harvard University Toxicological Revievs (3-ll*-50 to 6-30-50) 3 , 000.00 University of Cincinnati Carcinogenicity Fluorine Study (11-28-1*9 to 6-30-50) 38,963-39 1,500.00 TOTAL PAYMENTS TO 6-30-50 BALANCE AVAILABLE 7-1-50 1*0,1*63.39 1*3 ,1*6 3 .; 10,9053 Tentative Budget for Year Ending 6-30-51 Harvard University Toxicological Revievs 10, 000.00 University of Cincinnati Carcinogenicity Fluorine Study 92,000.00 2,500.00 TOTAL TENTATIVE BUDGET CONTRIBUTIONS NEEDED TO FINANCE TENTATIVE BUDGET 91*.500.00 10U.500.00 93,59k.l NOTE: If I9U9 contributors should give 150^ of the 191*9 contributions the total for 1950 vould amount to $96,510. API 04903 T 1$, 19*9 Ir. Bobert A. bho* Unlrareity of Ciaelaaatl Xettcrlag Laberatcrj o Applied Phpaiology Cinclanati 19, Oblo Sear Sector I M m : At ita 19*9 MBitl aaetlag tha Inetitute'a Medloal Adrlaarp Cccadttee rotad to Ocotlana lta finaneial anpport to tha ciooparatlra atad? on flacrine at a rata aot to aasead $2,500 par rnr. Va *iah to changa tha aamal data of payaant an thla acoouat frm lormtar 28th to Jaly lat to aaka it eoararrant alth otbar apac1al proJacta) tharcfora, a ara r1a""4"g to aaad pea $1,5 0 0 en loraabar 26th to corar tha aazt aeran aootha. VIH thla ha aatlafaetory to yon? ary trtdgr yocra, DTSld API 04904 > I UNIVERSITY OF CINCINNATI DEPARTMENT o f PREVENTIVE MEDICINE AND INDUSTRIAL HEALTH N o v e m b e r 17, 1 5 4 9 CABLE ADDRESS: SET LAB. CINCINNATI TELEPHONE: CAPITOL MIA Kr. D. V. Stroo; A m e r i c a n P e ttrrooll e u m I n s t i t u t e 5J V e s t p j t h Street, Ilev Y o r k C i t y 2 o . Dear Mr . S.troop: I am glad to knov from your letter Medical Advisory Committee sav fit cf A.?.I. financial support to the of November 14 that the to approve the continuation cooperative study of fluorine. Any m a n n e r in v h i c h it is c onvenient to y o u to f u r n i s h the funds vill be entirely satisfactory for our purposes. xcu vill remember that ve appl i e d the first grant of fund^bas at the beg i n n i n g cf the calendar year,vhich cane some months after the receipt cf the g r a n t . Since that time ve have continued to employ these funds on that kind of a d e layed schedule vithin our ovn budgetary year, vhich coincides v i t h the calendar year. Therefore, any means by vhich ve receive the funds, during the continuation of this project vill be vholly satisfactory. Sincerely yours H A K ef * d A merican P etroleum Institute 5 0 W E S T BOTH S T R E E T NEW YORK 2 0 . N. Y. November 25, 19^9 Dr. Robert A. Kehoe University of Cincinnati The Bettering laboratory College of Medicine Cincinnati 19, Ohio Dear Doctor Kehoe: Pursuant to the understanding reached by our letters of October 28 and November 5, 19^7 as modified by letters dated November l*t and 17, 19^9, ve are enclosing the Institute's check in the amount of $1,500 payable to the University of Cincinnati as our contribution towards the development of information on fluorine and fluorine compounds for the seven-month period ending June 30, 1950* Very truly yours, D. V. Stroop DVS;d Enclosure me: Mr. Baird 1. Markham Dr. A. E. Hoag Mr. Lacey Walker Members, Safety Coxn&lttee of the Board of Directors Members, Medical'Advisory Comlttee API 04906 A merican P etroleum Institute SO W E S T SO th S T R E E T NEW YORK 2 0 . N. Y. November 25, 19^9 Dr. Robert A. Kehoe University of Cincinnati The Kettering Laboratory ' College of Medicine Cincinnati 19, Ohio Dear Doctor Kehoe: Pursuant to the understanding reached by our letters of October 28 and November 5, 19^7 as modified by letters dated November lk and 17, 19**9, v are enclosing the Institute's check in the amount of $1,500 payable to the University of Cincinnati as our contribution tovards the development of information on fluorine and fluorine compounds for the seven-month period ending June 30, 1950* Very truly yours, D. V. Stroop DVS:d Enclosure me: Mr. Baird E. Markham Dr. A. E. Hoag Mr. Lacey Walker Members, Safety Con&lttee of the Board of Directors Members, Medical Advisory Canmlttee API 04907 A A merican P etroleum In stitute S O W E S T BOTH S T R E E T NEW YORK 2 0 . N. Y. November 25, 19^9 Dr. Robert A. Behoe University of Cincinnati be Kettering Laboratory College of Medicine Cincinnati 19, Ohio Dear Doctor Kehoe: Pursuant to the understanding reached by our letters of October 28 and November 5, 19^7 as modified by letters dated November lU and 17, 19^9, ve are enclosing the Institute's check in the amount of $1,500 payable to the University of Cincinnati as our contribution towards the development of Information on fluorine and fluorine compounds for the seven-month period endlr* June 30, 1950- Very truly yours, DVSrd Enclosure D. V. Stroop me: Mb. Baird H. Markham Dr. A. E. Hoag Mr. Lacey Walker Members, Safety Committee of the Board of Directors Members, Medical Advisory Committee 9 A merican P etroleum Institute 5 0 W E S T SOTH S T R E E T NEW YORK 2 0 . N. Y. November 25, 19^9 Dr. Robert A. Behoe University of Cincinnati The Bettering Laboratory College of Medicine Cincinnati 19, Ohio Dear Doctor Kehoe: Pursuant to the understanding reached by our letters of October 28 and November 5, 19^7 as modified by letters dated November lU and 17, 19^9, we are enclosing the Institute's check in the amount of $1,500 payable to the University of Cincinnati as our contribution towards the development of information on fluorine and fluorine compounds for the seven-month period ending June 30, 1950. Very truly yours, D. V. Stroop DVS:d Enclosure me: Mr. Baird H. Markham Dr. A. E. Hoag Mr. Lacey Walker Members, Safety Cosmlttee of the Board of Directors Members, Medical Advisory Cornaittee API 04909 B A merican P etroleum Institute SO W E S T SOTH S T R E E T NEW YORK 2 0 . N. Y. November 25, 19^9 Dr. Robert A. Kehoe University of Cincinnati The Kettering Laboratory College of Medicine Cincinnati 19) Ohio Dear Doctor Kehoe: Pursuant to the understanding reached by our letters of October 28 and November 5, 19^7 as modified by letters dated November lh and 17, 19^9) we are enclosing the Institute's check in the amount of $1,500 payable to the University of Cincinnati as our contribution towards the development of information on fluorine and fluorine compounds for the seven-month period ending June 30, 1950. Very truly yours, D. V. Stroop DVS:d Enclosure me: Mr. Baird H. Markham Dr. A. E. Hoag Mr. Lacey Walker Members, Safety Committee of the Board of Directors Members, Medical Advisory Ccmittee API 04910 r f l t f TT**"' W M W TORT " I l g ( o r NEDICIME-- EDEN AVENUE a N W T i IP. OHIO 3 UNIVERSITY OF CINCINNATI DEPARTMENT OF PREVENTIVE MEDICINE AND INDUSTRIAL HEALTH November 29 1949 CARLE ADDRESS: EETLAR. CINCINNATI TELEPHONE: CAf ITOl MM Mr. D. V. Stroop, . American Petroleum Institute 50 V e s t 50t h S t r e e t , N e w Y o r k C i t y 20. Dear M r . Stroop: I herewith acknowledge with thanks receipt of American Petroleum Institute's check in the amount of $1500.00, covering expenditures to be made on behalf of the Fluorine Project for the period D e c e m b e r 1, 1 9 4 9 to June 5 1950. Very truly yours E.' . F o r t l a ^ , S e c r e t a r y to Dr. Kehoe ef API 04911 ESSO STANDARD OIL COMPANY M edical D epartm ent E s s o B u ild in g , 15 We s t 51s t S t r e e t . New Y o rk 19. N. Y . rt,r B W OODY. M. D. <**>** *CTOB M g. DENHOLM. M. D. 1 . . l i e 1 M I D I O . L D I I . C T O . , _ KT P. S IM . M . D. * 0 S ^ ,,r tO B P *T lO iA - - g F. LEO N E. M. D. TH OM AS G. E L IA S. M. D. C L IN IC IA N C LY D E M. B E R R Y . PH . D. IX D D IT U A L K Y O IR N IIT December 1* 19^9 Dr. E.L Stroop laerican Petroleum Institute 50 vest 50th Street lew Tort 20, Dear Mr. Stroop As requested in your letter of yesterday, I an herewith returning the iU M of eipendltore. d. .t the lettering ^horetow- ery truly yours, sh Ene. 04912 KP1 T Wortafoer 3C ; 19*9 Is*. HaTncr Vooiy Euao Standard Oil Craqauay 15 Waat Slot Street la v Turk 19/ 3 . T . Saar Doeter Woodyi War year infcraation and. yoaaltle ecBnt tfcars la ooaloeed. atatsanot of axpaadltnroa nade at tha Eattarlm Laheratory oa tabalf of tha Aaaarieaa Potrolaaa Institute for the third quarter of 19h9. file. Plaaaa return the atateanst for oar ary truly yours, DTBtd Xnola API 04913 ^ t f T T E E l LAEOHATOHT , Qf NEDICIN I-- EOEH AVENUE ,, A T I n . OHIO UNIVERSITY OF CINCINNATI DEPARTMENT or PREVENTIVE MEDICINE AND INDUSTRIAL HEALTH November 2:, I?-- CAELE ADDRESS: KETLAS. CINCINNATI TELEPHONE: CAm tol M U Mr. D. V. t r o o p , She American Petroleum 50 west pCth Street, Mew Y o r k City 20. Institute, Dear Mr. Stroop: I am sending you herewith, for your information, a statement of expenditures made on behalf of The American Petroleum Institute for the third quarter of 1949. If you have any question or comments, Doctor Eehce would appreciate your bringing them to his attention. el me API 04914 t UNIVERSITY OF CINCINNATI KETTERING LABORATORY ACCOUNT OF TEE AMERICAN PETROLEUM INSTITUTE For the Third Quarter 1949 .otS (Based on Proportion of Time Actually p-" Spent on Project) prancis Heyroth A. Wesley Horton Dorothy Templeton Bussell Tye jarl Korpi S y lv a n Witherup jdvard Svillinger Carol Brown I^.TJUEEOUS purchase EXPENSE of Animals Chemical and Toxicological Asst. Chemical Assistance Technical Assistance I n 0 Laboratory Supplies Traveling Expense . proportion of Secretarial, Library, Janitors, Wash Boys, Draftsman, Shipping Clerks, Animal Caretakers, Histopathological Preparation etc ............... Proportion of Heat, Gas, Electricity, Steam, Sfcs, Telephone, Maintenance, Pensions, Annuities etc . 208.71 1800.00 404.84 750.00 110.38 53.05 22.24 4.50 3353-72 Total 12,635.83 felance Remaining for Work in 1949 . at End of Second Quarter 1949 .................. $59,861.61 ipenditures Third Quarter 1949 .................. 12 ,635.83 Glance Remaining for Work in 1949 at End of T h M Quarter 1949 . . ......... $47,225.78 s A i t API 04915 .-ilit o , i i f i p :11* lA P isMunam -- $ w 31 19*9 TT 1915 19*7 1913 1919 fOtti iwiilturii m Prior to lanrarA Pnlfrilty TC9ElelflitlOAlTlW Cattine Oli Btajr 1*1t-- l t r ofC ljfl im iti Mrolaaisalclt^ fin arla* ttadjr $28,900.00 27, 800.00 96, 300.00 W .00 $219,310.00 #37,000.00 8.000.00 3 9 *5 0 0 .0 0 U 0,U 3.00 <00 126, 913*00 *o*nan*ou look* fa r Co--ltt* * Om WHI XXRBDBB 57.77 jijQ:n n y * t * >*mlr*4 le I t f w d Ikiwillr "tw d ooio*ion llari** Jh X m itr of e * -* - * Carelaoeraeltj f| rri* l ir a i--t* W atll 6-10-50 (3*11-50 to 6*30*50) ,3 000.00 58,869.23 TO 6-30*50 *1,963.39 AOTLBI 7*1*50 10,905.81 W . f t y I< J dKl1M1l? a&yIm t j torri*** M T F r t V fclwnltT of Claela-tj earalaaf-- loliy finarla* Stndy 98, 000.00 eunuLUUUGBB mrpgT) to r o u a m u o n 5, 000.00 AQ:.oo 99.500.00 $ 88,591.16 1-10-50 API 04916