Document 7R375eLqnzRDX4ONEVb10qBk8

AR226-3070 DuPontHL-1997-00260 HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE STATIC, ACUTE 96-HOUR SCREENING TEST OF H.22274 TO FATHEAD MINNOWS, PhneolMto proroehB PURPOSE: This is a rangefinding study designedto provide an estimate of aquatictoxicity using fixed test concentrations and data measurements at predetennined intervals. GENERAL INFORMATION MR: HASKELL NUMBER: TEST CODE: MATERIAL TESTED: SYNONYMS: SPONSOR: NOTEBOOK ED: SUBMITTER'S NOTEBOOK NUMBER: COMPOSITION: CONTAMINANTS: OTHER COOES: CAS REGISTRY: PURITY: TEST CONDITIONS Nomicel concentrations tested: 0,0.5,1.0,50,500, and 5000 mg/L. Nominal Concentration (mg/L) At Test Initiation, 0 Hours Dissolved Oxygen (mg/L) pH At Test Completion, 96 Hoora Dissolved OxygeD (mg/L) pH 0 0.5 1.0 50 590 5000 9.2 7.5 9.2 7.5 9.3 7.5 9.3 7.5 9.3 7.5 9.2 7.4 6.9 7.6 6.7 7.6 6.8 7.6 6.5 7.6 6.4 7.6 9.2' 7.2' ' Reading taken at approximately two and one half hours after exposure, due to total mortality. Page 1 of? Does not conta,n TSCA CB6 Company SanUilizeda. u DuPontHL-1997-00260 HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE STATIC, ACUTE 96-HOUR SCREENING TEST OF B-22274 TO FATHEAD MINNOWS, Pimenhalea prrrrtlfti CONTINUED RESULTS Based on visual observations, the water control solution was clear and had no color. The OS, 1.0, and 50 mg/L test solutions were clear and had no color. The 500 and 5000 mg/L test solutions were cloudy. white in color. Mortalities were 0,0.0,0,0, and 100%, respectively. The 96-hour LC50. based on nominal concentrations and mortality, was between 500 and 5000 mg/L. All water quality parameters were within acceptable limits. CONCLUSIONS H-22274 exhibited low toxicity in a 96-hour, iinaernted. static acute test using fathead minnows, Pimephales WORK BY: AUTHORED BY: APPROVED BY: ^u^' W.Wetzel ^ icology Associate .()i/^aA^fj[d^w^ Deborah L. Dobrzynski ^' Toxicology Associate ~ ^ / ^ % ^ ^ Micheife R. Brown/S.A. Study Director ^ - A 7 Month/Day/Year ^31^ Month/Day/Year M ^ / ^ Monlh/Day/Ycar DISTRIBUTION: Page 2 ^conlalnTSCACB? Company Sanded. Does