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TOXICOLOGYTOXICOLOGY ENVIRONMENTAL SCIENCES CHEMISTRY PLANT SCIENCES MEDICAL SCIENCES Industrial BIO TEST Laboratories Inc. 1810 FRONTAGE ROAD NORTHBROOK ILLINOIS 60062 April 19 1977 AREA CODE 312 TELEPHONE 272-3030 @ Dr. Michael Chudkowski Research Toxicologist Johnson & Johnson Raritan New Jersey 08869 Dear Dr. Chudkowski Re IBT No. 8562-09039 - Cornstarch Subacute Inhalation Study in Golden Syrian Hamsters As per your letters of March 2 and March 18 1977 the following revisions have been made 1 A Table of Contents and List of Tables and Diagrams have been added 2 The phrase Cornstarch Baby Powder has been replaced with Cornstarch Powder Base on pages where it previously occurred In addition your identification for the powder BPC 4030-106 has been added in the title of the report 3 A sentence clarifying related to the method of sacrifice has been inserted on page 46 4 The phrase -40 dew point has been added on pages 2 : and 5 in describing the chamber conditions for the control animals 5 A diagram illustrating the dust shaker mechanism has been added on page 6a 6 The tissues actually examined have been added on page 15 and the phrase protocol required deleted Protected Document to Protective order JNJ 000060423 @ Dr. Michael Chudkowski April 19 1977 In addition typographical errors were noted and corrections were made as follows a On page 27. the 86 day total leukocyte count for animal 4 has been changed from 10.0 to 10.1 b On page 32 the 44 day Hematocrit value for animal 151 has been changed from 40. 2 to 50. 2 C. On page 35 the 86 day neutrophil count for animal 129 has been changed from 22 6. changed from 18.7 to 16. 9 The mean has accordingly been d On page 36 the 86 day neutrophil count for animal 35 has been changed from 24 to 34 e. On page 46 the word those has been added as the first word of the last sentence g ' On page 50 the finding of focal congestion agonal has been changed from day 24 to day 25 On page 53 the finding of multifocal necrotic hepatitis has been added as a finding for liver with a grade of 1-2 for animal 126 the grade of 1-2 for focal necrotic hepatitis for animal 126 has been added Sincerely FKK CC J. W. Goode F. K. Kinoshita D. Technical Manager Toxicology Protected Document to Protective order JNJ 000060424