Document 7OOOdK30Kmp1xaQ0B0DLNvRpe

Torrcoanor /ra> uroiniE o? iiaDfrntTAL sjLverrs K. B. Lehmann and F. Flmry with a preface by Dr. H. Belter Translated by Eleanor King and Henry F. Smyth, Jr., from the first (1933) German Edition Part 1, Pages 1-166 b?G03494 20455001 * n This translation has been prepared for the use of Dr. A. G. Cranch and Dr. H. T. Snyth, Jr.' Page ntribers of the original Geraan text ore indicated in the left nargin at the beginning of the translation of each page. In many cases a aenclnture has been changed to agree irith Anericnn usage. TTherever possible concentration data has been expressed in p.p.m. or voluce percent (10,000 p.p.a. = 1 Vol.S), in addition to the sign, per liter figures of the original. The conversion factor has been added to the physical properties section under each solvent nrne. Other editorial changes have been held to a minimum. Ho attempt has been node to change the descriptions to agree urith current American industrial nethods. Unfortunately, it has proved impossible to be consistent in the listing of literature references. i BFG03495 20455002 143 The pmralyTir.g t'Zcc' occurs mart rIsrly th'n rith chloroform. Locxl Irritiii-p -.-ffact rfceu it is introduced intc ikt gnstro-iniertinel tract Ho cornc-tl clouding. The antiseptic effect is stronger then -.-ith pentachlor- cUirnc (Joachisoglu, 1921). 3ex".c:`.loreiumne is, rithout doubt, r. very toxic iUbstsnce. Or. fro^d heerts it proved to bv 10 tines more effective turn pentackiarctl'ane. i-'a liver injlay ras found in dog? after inh:-.latlon (i>ioff, 1923). then used in animal therapeutics, however, gastro-intestin-r.! irritating symptoms end kid ney injuries rere observed (Tapcxmcux, 1930). Ir.dumtri-tl -olrcnir.rs crc unknora. They mould come into considera tion rith infuvtriiJ. products milch contain hexachloretheae, e.g. rith spraying. norever, the anger of a poisoning by the inhalation of vapors is --slight (Literature: fine, 129;, lies.-.ling, 1921, Jonehimoglu, 1921, staloff, 1923, Tapernoinc, 1930). Uonochlorethvlene (Vinyl Chloride) " Fornul-i CHo* CHOI Molecular ireirht: 2.10. 1 mg. per liter = 391 p.p.s. General iro-i.rtiee: b.p. -1SC. Easily soluble in alcohol and orgenie sol vents. Combustible, tut less explosive than ether. Gsseous at ordinary temperature, "he edcr is ream, rimilsr to et'yi chloride, seeetlsh. TTh-n diluted is practically odorless. Colorless gas, hence not a solvent. Ileverthelesc, the substance rill be treated here for the sake of comparison. General character of effect. Local irritating effect very slight. "Highly narcotic. Great distance between narcotic-end-dangex-ous concentrations. General toxic effect very slight. Catabolic injuries have not been detected --es yet.- Kcommended especially mom .supplementary narcosis rith laughing gas and oxygen (Schr.umx.nn, 1934). ` Absorption occurs very quickly. i distribution. In narcosis the blood contains 15-17 eg. %. Elimina tion occurs very quickly, sore quickly than rith ether or chlorofem. After 10 minutes 82S ras eliminated (Schausann). Animal experiments. According to experiments carried out by Sehaunann (scaa of rhica are still unpublished), vinyl chloride is very suit--able for narcosis, that is, for-susalcm-ntary narcosis, or. account of its slight toxicity, its rids range Df effect, its lor concentration in the bicod and its particularly rapid elimination. Titfcin the narcotic limiting doses heart end biooa pressure arc not influenced to any extent. .!igli concer.trntions increase the blocs pressure. There are no secondary or after-effects. Uice rad rats were able to endure slight vinyl chloride narcosis for o5-8 consecutive deys for 4 hours et a tine, end every day for four weeks for 1 hour at a tins rithout liver and kidney injuries. cnDogs, rhieh rere able to endure reposted ntrcooes, ns many es 7 in o3 reeks, each lasting 3 hours at 10 Vsl. shored no considerable organ enanges in the liver and kidneys, "ith dogs at 20 Vol. respiratory paralysis, o strong flee of saliva, and, after narcosis, vomiting occurred. CO BFG03496 - (131) Further axpsriaents ' ere carried out >y Peoples and assistants, 1?33, on sics, r-'tbltj and dofs, and by and csslstcnts, 1933, on gui.-.c; ploS, Those uihors obtained es; entinily the sane results, cspecirlly in recard to the comparative herulescness even after repeated narcosis. According to fehauarnn the narcotic Uniting concentration for humane is 7 - 10 Vol, %. Above 12 Vol. f: it is dangerous. 20 - 40 Vol. f- is fatal for guinea pigs in a short tine, 10 Vol. is endured for several hours (Patty, font, Feite, 1930). . For nice life smallest concentration rhich is fatal in 10 ninutes is 10-12 ieillinol/1 = abcut 25 - 30 Vol .S'., about 3.5-5 tlllimol/l = about S - 12 Vol. 3 is the sasllest narcotic concentration (Peoples and Leske, 1933 Death occurs due to respiratory paralysis rlth resultant arrest of the heart's action. `The toxic effect of vinyl chloride is such slijihicr than that of chloroform end that of carbon tetrachloride. According 'a Patty and assis tants, it is about eo.ual to that of ethyl chloride. According to Schaunrnn the effect on the heart is even less than that of ether. In aninsl experiments the respiration is at flirt increased, then beconcs irregular, is flattened out and sloped dons, but it reasons regular In narcosis. Dissection. Hyperemia of the lungs end kidneys, pulmonary edena. Scheunann found no serious pathological changes after repeated narcocis in dogs, nice, and rats. Effect on hurr.no. Confusion, intoxicetion, burning of the soles of the feet and other subjective disturbances, head-aches. Recovery takes place very quickly (Dublin and Vane, 1935). Industrial noioor.ines are not knoi.n. -Vinyl chloride is one of the _____ least dangerous of the chlorinated hydrocarbons. ----- Dlchlorcthrlene-(12) Symmetrical dichlorethylcne, a mixture of cis- end -trans-- compound. Formula; CnJIpClp tioleculer rcirht; 94.94. 1 mg. per liter ---252-p.p.a. -General uroy.TSieo; b.pi'about 55-0C. Sp. gr. 1.25- Difficultly combus tible, not inflammable, but can be decomposed in open flames. Very volatile. Solvent for acetyl cellulose, resins, .tjccs; the canufocture of synthetic pearls, the extroction of rubber, the refrigeration industry. Fas also used as a narcotic for a time. Gcners 1 chnmctcr of effect. Strong irritating effect, corneal clouding, iiarcosis, muscular spasms. Toxic effect couparr tivdy olirht. Uetr.bolic injuries then tiis effect lasts for a longer period. The mixture consists oT stereo isomers, the cis fora boiling et 39 C and the trans fora at 4SC. 20455004 BFG03497 Peoples, A. 5. end C. P. I.eakes J. of PbnrvicDl. 13 281 (1953}. fCltczcy, C.s Atch. Ccwcrbroatl.. Z, 591 {1938}. Pfrc-rditcr, -i.: I?tech. Z. EcriehU. ~ed. 18, 339 (1931/32). Plocr.c, a.: biochsm. Z. 113, 129 (1921). Plesm-_rJ rihckr. Prychiatr. 39, 129 (1916). Plcsr.nar: fieri, kiln. "sehr. 1916 I, 514 Plesroer! Ocur. Zbl. 35, 350 (1916). Plots, r.: Bloeliea. i. 103, 243 (1920). Poindexter, C-,,A. end C. H. Greene: J. acer. ned. Assoc. 102, 2015 (1934). v. Bedsits: nvnck. r.td. 'ser.r. 1933 I, 497. Reich: Sic. Vcrsiftgs.slle 5 (1934). Rcuss, A.: Dlss. vurzburg 1931. Robbins, i*. il.t J. of pharrajol. 37, 203 (1929). Rohola, K.: C.'eskr. Lae-;.-(dan.) 95, 1133 (1933). Roth, 0.: Scsneis, Z. Unfallhcilk. 17, 169 (1923). 8snsoa, A. .: Brit. tied. 3. 1367, 206. Sayers, R. , 1'. P. Tant, B. 0. 3. Thoaas end 1. B. Berger: 0. S. Publ, Health Bull. 1929, 3o. 135. Sayers, h. R., ?. Tint, C. P. hnito and S. A. Patty! 0. S, Publ. Health Keo. 45, 225, (1930). Scsanxio, A.s Arch, di Antrop. eriain. 47, Suppl. -a., 555, (1937). Scbaraann, 0.-. Uedizin und Cheaie. Abh. cad. -chan. Forscbgsstatt. J. 8. 2, ------- 139 (1934). Schauosm, 0.: Arch. f. exper. Path. 131, 144 (1936). Scbeurlec, v, 8. ritaky: 2bl. Cecerbehyg. 12, 60 (1935). Scbibler, : ^chreis, tied. Vschr. 1929, 1C79. Setlingsann, A. S. end 0. n. Gruhsit: J. axer. vet. ned. Aggie. 71, 1S9 (1927). Schultse, .1 3crl. klin. sehr. 1920 I, 941. Sclrar, H. A J. liesel: ""ien. idin. ''schr. 1903 I, 247. 5chut:, H.s Arch C-crrerbspath. 3, Z69 (1938). Sehianeer, P.: Arch. Ces-arbepatk. 7, 1C9 (1936). Sehtrart.2, F.: Btsch. Z. geriehtl. lied. 7, 273 (1926). Sehuars, F. OH. Zangger: Zbl. Getrerbchyg. 3 , 246 (1926). Schwarz, JJ. C.: Arch. klin. Chir. 153, 3S6 (1923). Schoenkcnbceher: Arch. f. (Anat. u.) Physiol. 1904, 121. Snyth, H. F. and H. 7. Snyth, Jr.!--J.-eaer. d. Assoc. 107, 1633 (1936). Snyth, K. F., H. F. S.cyth, Jr. end C. P. Carpenter: J. ind %g. IS, ----- 277 (1936). Steindorff, K.= Dtsch. ned: Fschr. 1922 II, 1466. Steindorff, X.= Grades Arch. 109 , 252 (1922). Storat: Ztsch. ned. '`schr. 1910 II, 1362 quoted by "ochoaim. Striker, C., S. C-oldblatt, J. S. Kara and D. E. Jackson: Anesthesia 4 . . Analgesia 14 , 68 (1935). Stuber, R.: Arch. Otwerbcpath. 2, 393 (1931). . Sydcnstricker, V. P. C., B. J. Galatour and G. H. Fhipple! J. of exper. Hod. -19, 536 (1914). TeVr.saka, T.: Btseft. 2, geriehtl. *cd. 6, 4S8 (1925). Tepcrnoux: C. r. Soc. Biol. Paris 105, 654 (1930). ""Tauber: Zbl. ned. figs. 1630, 775. Tcylor, H.: J. ind. Hyf. IS, 175 (1936). Tclcky: Klin. "schr. 1927 1, 345 , 897. Ticttc, A.: Arch. Gcrerbcpath. 4. 733t(1933). Valles, C. J. Ltclcrcq: Ann. iiea. leg. ate. 15, 10 (1935). Velcy, H.: Lancet 1909 II, 1162. Villinccr: Arch. klir.. Chir. 83, 730 (1907) trailer, A. Z>.: quoted by Kochnarm. v BFG03498 20455005