Document 7MoJ2nQ2Z1xKvKVD6z4x0w9ga

M * 9 > - I th th C E. I. du Pont de Nemours Sc company INCORPORATED P. O. Bex 12*7 PARKERS3URG, W .VA. 2 6 :0 1 PLASTICS DEPARTMENT COMPANY CONFIDENTIAL C C : J. W. Attacher T. L. Miller Pile: 11-0-4 February 18, 1970 TO: J. MITCHELL, JR/--PLASTICS DEPARTMENT EXPERIMENTAL STATION FROM: W. E. HILTON FLUOROCARBONS DIVISION WASHINGTON WORKS REQUEST FOR TOXICOLOGICAL INFORMATION - "TEFLON" DIVISION CHEMICALS Past studies made at Haskell Laboratory have indicated that ammonium perfluorooctonate (C-8 APPC), which is used in the preparation of "Teflon" dispersions, is highly toxic when inhaled and moderately toxic when injected. However, data are not available on the chronic local or chronic systemic effect of the compound In the solid state or dissolved in "Teflon" dispersions. A review of the medical history of employees in the dispersion's area revealed that with the exception of two cases of dermetitus, which were probably due more to temperature and moisture than specific chemicals, there have not been any indications of toxicological effects of chemicals. The plant Medical group is aware of the potential effects of the area chemicals and monitor area employees, both individually and statistically. We are interested in determining the systemic effect for repetitious skin contacts of short duration with C-8 APFC powder and with the aqueous dispersion of polytetrafluoroethylene containing C-8 (or chlorendic acid). We are also interested ii determining the chronic effect of inhalation of minute quantities of C-8 APFC. In addition to knowing these effects, we would like guidance on the personnel equipment necessary for adequate protection against these effects. Would you determine the cost of each separate study, the potential for beneficial data *j/*~*/J 4 000080 EID123138 :v . ,\-v DUP001005 J. MITCHELL, JB. -2 February 18, 1970 beyond our ability to extrapolate existing qualitative data, and if the following data is sufficient for Haskell L a b 's purposes. C-8 APFC Charging REDACTED 000081 J. MITCHELL, JR -3- February 18, 1970 REDACTED 000082 Haskell Number HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE SAMPLE SUBMITTED FOR TCKICITY EVALUATION Department Plastics Division Fluorocarbons Location Washington Works Systematic Name of Chemical: - Ammonium Perfluoroocttanoate ; ;, Synonym, Product Name and/or Designations: ,3M*s Wetting Agent FC-143, C-8 APFC " Formula: CF3 (CF2 )6 COONHjj Sample: Code No. Grade______ Lot No._______________ Amount ______________________ Color White Form M ol. Wt,_____________ v l Special Handling Requirements _____ : 'V Is it explosive in air? No la oxygen7 ? if so, at what concentrations? ; Active Ingredient C-8 APFC ______ 95_______ 36 Conqposition, if a mixture (are percentages by weight or volume ?) 95%C-8 Minimum .... 5%C-6 Maximum 5%.Impurities (identity and amounts; are percentages by weight or volume?) C-6 Maximum ' | Decomposes- 150C 25C Negligable Properties: MP -- BP -- VP X '. 2%@ Max. Process Temp. 100 Aqueous Solution Sp.Gr. p H ^ M i n V apor Density (air l ) c (Attach HP curve if available) ' Flash Point (Open c u p ) * (Closed cup) .. '! v Solubility (Quantitative, if possible) in water Yes A cetone Ethanol Vegetable oil Other Solvents_____________ i .Proposed Use: ' 11 Ingredient in Polymerization Recipe-./. ' Present Stage of Development : Research ; .fitoighrfcs MO u ' >j 'l . \\ 0000S3 .Sales/ (OVER) . EID123141 Employee Exposure 1 Concentration of material in process____________ 1200 PPM ________ 2, Solvent and other chemicals present Water, Disuccinic Acid Peroxide 3. Is exposure by inhalation X skin absorption X other 1*. Maximum temperature of material in process 100C 5. Is the compound present in the atmosphere in the farmjof vapor-' No_____ C.. j \ mist No dust S 1 1 g-bt: 6, Maximum concentration likely to be present in atmosphere Unknown______ 7. What type of ventilation is in use? High Volume _________ _ 8, What type of protective clothing is worn? Gloves, Goggles, Dust Mask 9. Exposure is for Consumer Exposure hours - minutes per day See Attached r,ttpr> ' .. . What is possibility of: By Emolovee j* 1. Ingestion 2. Inhalation 3. Skin contact Very Slight Minor Quantity Pair NOTE: See Attached -Letter for Write-Up h. Eye contact Experience to Date Slight \ Have any clinical signs of toxicity such as headaches, difficulty in breath-* ing, dizziness, nausea, skin or eye irritation, etc., been reported b y persons ; who have been in contact with the chemical? If so, please list them and des*r cribe circumstances under which they occurred. r i :VV j No j 1( i ) 1 i i\ tl l . i- tti-' 1- 1 ;i . f i . .t/ir; NOTE Haskell Laboratory will retain the unused portion of stable, nonflammable, , nonvolatile, low toxicity samples for 5 years unless requested to return . to sender immediately alter testing. After 5 years, the samples will be : discarded or returned to the appropriate department. It is suggested that the sender also retain a suitably identified portion of the sample - sent for toxicity evaluation, for his own future reference. I S i g n a t u r ii l j.I EID 123142 DUP001009 J. MITCHELL, JR. February 18, 1970 TABLE I Ammonium Perfluorooctanoate (C-8 APFC) Formula: C F 3 (CF2 )g COONH^ Manufacturer: 3M (FC-143) Previous Tests: Inhalation, MR No. 1198, Haskell Laboratory Report No. 160-69 Oral, MR No. 604, Haskell Laboratory Report No. 55-61. Chlorendlc Acid Formula: CpH^O/jClg Manufacturer: Hooker Electrochemical Company Previous Tests: O r a l , M R No. 60*1, H a s k e l l L a b o r a t o r y R e p o r t No. 1 - 6 3. DUP001010 ooooss EH) 123143