Document 7MnnqXMR2r675GYGw0g2ZB31a

o s - (t, 7 1 A June 3, 1957 Nr. Allen 9. Brandt Chief Ind. Hn< hciimr Bethlehew Steel Coapeny, Ino. Bethlehew, fennsyIrani* Mar AH Thggjoufwe^yeur letter of Hay 31 requesting taxloity date on f The range finding toxicity data indioatea that rata surviTed dotages of 58.0 grans per kilogram of body weight, this indieates that the \ Material is praotloally iimooueus" when fed orally to this speeie. the Hlntaai Lethal Oral Bose for rabbits ms 3.5 to A.5 grans per kllsgraa and following skin absorption in rabbits the lethal dose was A to 5 grans per kilogram, Obviously, the rabbit is a auoh nora sensitive speeie to this fluid. j Akin and era irritation studies with anlaals indioatea that at hour oontaot resulted in less irritation than results when a 10 per oent I soap solution is tested sinilarly. - Rats survived 6 bourn exposure to an atnosphere saturated with vapors / of ths fluid* Vapors worn introduoed into a suitable aniaal ehamsr br bubbling nonprossed air through an orifioe iansrsed in the liquid. The vaper-laden air straan was then passed through an iapinger flask to eapture droplets or aerosol and to allow only vapors to pass into the ehsNber. VTho antwals were net seriously affooted by the expoeurei breathing raaainad regular although there was slight irritation of the respiratory treat as evldenoed by salivation and slightly reddened auoosa. the exposure oeuaed only a slight dogma of laerlaatlon. we interpret the above aniaal toaielty data as Lndieating that the j fluid possesses a very low order of taxloity, rraotloal experienae with fydraul Ad and other seenwhat slallar fluids ham shewn, however, that aoeldental oontaot with the eyes of wortaon oausea pain out of proportion to the degree of irritation obtained in anlaals. This has ooourrad whore droplets of the fluid have been splashed In the eyes or where wortaon night have the fluid on their hands and wipe i, their eyes. Xn no ease has there been any danage to eye tissues or \ iapaimsnt ef vision. The seeend praotioal eonslderation refers to a suggestion that work* ran avoid needless prolonged skin oontaot prlnolpally beeauae the fluid has an exoellent solvent notion whloh oan defat the skin and MUMS 091000 Hr. Alim D. Brandt--Page 2--June 3, 1957 lead to possible Irritation. Although I am not at liberty to dleelose the ooaponents or Pydraul AC, X can tell you that the vapor pressure la extremely low with boiling point* at 70 something over 350C. X think It highly Improbable that any significant oonoentratlons of fluid would thus be picked up by the oeapressed air and reach workmen using air masks connected to the coopreseed air line. We would not hesitate to use the fluid In compressors within our company where air masks might be eonneoted to the compressed air lines Intended primarily for other usee. We have Indloated this thought In correspondence with other potential users and presumably there are a number of applications throughout the country where the fluid is now being used and as desorlbea In your letter. Enolosed is our Technical Bulletin ODB-56-27 on Pydraul AC) X hope you will find It helpful. Xf X ean be of any further help or add to the above Information, please let me know. Sincerely yours. EPVidh Enclosure Elmer P. Wheeler Assistant Dlreotor Medleal Department HONS 091007