Document 7MXLemQb2aVMOJezjdxM3Mq3E

NOTICE OF RESEARCH PROJECT TOX-TIPS SUPPORTING ORGANIZATION: National Institute for Occupational Safety and Health max!*1. a.1 may M oopjrlebt miBiiliiim Toxicology Information Program 8600 Rockville Pike Bcthesda. Maryland 20014 Tel: (3011 496 1131 SUPPORTING ORGANIZATION NUMBER(S): Contract No: and/or Control No: VNH-C21-545 PROJECT TITLE; Mortality, Medical and Industrial Hygiene Study of Workers Exposed to Polychlorinated Biphenyls INVESTIGATOR(S): DEPARTMENT/SPECIALTY,.SCHOOL OR DIVISION Dr. Blair Smith Mr. Dave Brown Mr. John Fajen Division of Surveillance, Hazard Evaluations and Field Studies PERFORMING ORGANIZATION: PERIOD FOR THIS NRP: Name and Address. Including Zip Code. National Institute for Occupational StartDate. Safety and Health 4676 Columbia Parkway End Date: Cincinnati, Ohio 45226 Annual Funding: October 1977 September 1979 t PROJECT SUMMARY: Polychlorinated biphenyls (PCB's) are a class of chlorinated aromatic hydrocarbons that are widespread in the environment, are highly stable, and tend to bioconcentrate in the food chain. Their current use is primarily limited to closed systems in the electrical industry as insulating material in capacitors and transformers. Reports of adverse health effects in humans and animals accidently exposed to PCB's, and the demonstration of carcinogenic effects in certain animals from certain PCB's have necessitated an evaluation of the toxicology of this class of compounds. In laboratory animals, structural function changes in the liver have been noted as well as hepatic tumor induction in certain species. Other documented effects have included gastrointestinal, endocrinological, hematological, and embryotoxic effects. In humans, the syndromes of chloracne, and Yusho neonatorum have been extensively documented. The mortality study is well underway; follow-up is near completion on the two study cohorts exposed to PCB. Several of the medical surveys have been completed. The industrial hygiene surveys on all plants that were included in the mortality study and medical study have been completed. DSW 379014 TOX-TIPS APRIL 1979 35-41 Sponsored by Toxicology Information Subcommittee DHEW Committee to Coordinate Toxicology and Related Programs STLCOPCB4099998 The bibliographic references (author, title, source) on this page have been obtained from searches of the following National Library of Medicine's on-line retrieval files: TOXLINE, CHEMUNE, MEDLINE. SDILINE. and QANCERLINE. The searches, made on the substances that are the subject of the test described in the Notice of Research Project, usually have retrieved the most recent citations from these files. Because these searches have not been exhaustive, the investigator may wish to obtain more complete searches on the test substances by searching the NLM on-line files or by contacting the Toxicology Information Response Center (TIRC) at the Oak Ridge National Laboratory. P.O. Box X. Building 20240ak Ridge. TN 37830 -- Phone: 615- 576-1743. i KUWABARA K ; YAKUSHIJI T ; WATANABE X ; YOSHIDA S ; KOYAMA K KUNITA N ; HARA X Relationship between breast feeding and PGB residues in blood of the children whose mothers were occupationally exposed to PCBs. INT ARCH OCCUP ENVIRON HEALTH; 41 (3). 1978 189-198 Yamaguchi M ; Baba T ; Rikioka Y Analytical studies on PCB in blood of healthy subjects. 1 Nagasaki-ken Eisei Kogai Kenkyusho Ho; VOL 16,, 1976,116-21 Criteria for a recommended standard. polychlorinated biphenyls (PCBs) U. S. NTIS, PB Rep.; ISS PB-276849,, Occupational exposure to 1977,234 pp. Kuwabara K ; Yakushiji T ; Watanabe I ; Yoshida S ; Koyama K Kunita N . PCB Residues in blood of mothers and their children. Relation* to feeding with human milk Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Shokuhin Eisei' Hen; VOL 8,, 1977,79-82 Kuwabara K ; Yakushiji T ; Watanabe I ; Yoshida S ; Koyama K Hara I ; Kunita N PCB Residues in blood of female PCB workers and their children. Part 1. Relation to feeding with human milk Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Shokuhin Eisei Hen; VOL 8,, 1977,73-8 Watanabe I ; Yakushiji T ; Kuwabara K ; Yoshida S ; Koyama K Hara I ; Kunita N Studies on polychlorinated biphenyl (PCB) isomers in blood of ordinary persons, oil sickness patients, and occupationally exposed workers. 2. Apiezon L column analysis Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Shokuhin Eisei Hen; VOL 8,, 1977,51-8 Colucci AV Epidemiology of pesticide and metal residues Comm. Eur. Communities, [Rep.] EUR; ISS EUR 5360, Proc. Symp. Recent Adv.' Assess. Health Eff. Environ. Pollut., 1975,1043-51 Int. Vol. 2,, i ii i) i TOX-TIPS APRIL 1979 35-42 DSW 379015 STLCOPCB4099999