Document 7MJp32nR9YpqYe8jxgYOJzkro

RAG -- 3245 hid 5o [ 0 uyD Orr Gy aE ge So--pans Gmpswiymt M2o2aDw6ur-es e3ss2s45 _ "TRADE SECRET Study Tide H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Volume 3 of 4 Laboratory Project ID: DuPont-6554 `TEST GUIDELINES: U.S. EPA Health Effects Test Guidelines (OPPTS 870.3100 (1998) --_ ' AUTHOR: Don A. Delker, Ph.D STUDY COMPLETED ON: April 22, 2002 "PERFORMING LABORATORY: E.L du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Worx Request Nove: [EY service Cove NovanzxJR) `CLINISCtALunPgATNHoOLmOeGY:,(ED | -- eWay sama rom TSCA GBI 124675: Subchvonic Toxicity --~ 00 DsyOral GavageSuudyinRas Dubomesst. APPENDIX C INDIVIDUAL BODY WEIGHTS -- -- - Company Sanita. Dossnotcontain TSCA CB 9H02.4D6a7y8:OraSlubGeahvraogneicStTuoxdiyciintyRats --~ INDIVIDUAL BODY WEIGHTS `StudyDesign EXPLANATORY NOTES MalGerouFpemale m1W ITVM V VI VIL VIL IX X Dosage O6m0gmkggk/gdlaayy 10mgkgday 60mgkgiday 300 mg/kg/day Test Substance Vehicle control Ilsopropanol control H24678 H24678 H-24678 DuPont 6554 CriticalDates Day90 > Last day of test substance administration for male and female rats designated for the one-month and 3-month recovery periods. Day91 > Last dayoftest substance administration for male rats designated for the 90-day exposure period. > Recovery period beginsfor ats designatedforthe one-month and 3-month -- recovery periods. Day92 >Lastdayoftest substance administration for female rats designated for the 90-day exposure period. > Male rats designated for the 90-day exposure period were sacrificed. > Male rats dosed with isopropanol (Group III were sacrificed. Day93 > Female rats designated for the 90-day exposure period were sacrificed. > Female rats dosed with isopropanol (Group IV) were sacrificed. Day 122 > Male and female rats designated for the one-month recovery period were sacrificed. Day 183 > Male and female rats designatedforthe 3-month recovery period were sacrificed. Note Unless footnoted, absent data indicates animal was not alive at the time of data collection. _-- Company Sanitized. Doss notcontain TSCA CBI 3 i ass 3.5 = i it dain or i 1 77 nSuEng igdaaais {2 gE ws Hi Simsg Hann i: um J i1 g is _ i= $3iiRnananataFnRnEiEiSsE 3 it SunEn R3iiR asneizaananeaenda 3i;:| anHadadHaas i: 8 "i4 3 EY Arma aNEmmeAeOn if i iia Ei unnREy i1 i: sanmumm i iis 1h: mn nmnmmmsnnm ors - 3g 3 g i or i fag7 gqiegndase 32 iiu EiiE ii8 io7 or22283 j i& [giad g3gzd i 37 $5588 i: wR HE or I I iiEy G.E aasne Fides 8 3 I3ITIIITTITIITIIIIIFIFENG re 3 3 5 8 , seneienane 3 07; HB8a3RnaRsNE3aIEAansg 5 ! ] 3,. RsaeiaEnensgaaEnEe g 3 Q i i sdddssssds i fe Emus ir oon 808 dugedndedd if fe0 ggssisesny Agd , snanoasess 1 _ FRaaraess gl $8: Bor ~3 g : 5 E iE ?2 i35 i : i: 3 if i iid P3 g2.i7 Em8E3E8a8m3aaE3E8R8s8 my2a g858Ra0828 5s| f: e3f2a8sunganeaass Ins Tnmmnasm -- 4 3 i1.3p S3EiEdEfRiEsEiasRiIetdaeaiRs z : oo 3 Ii+ mmeem :i He sagiiesiiages: : i: p$hEoGERnIgoERL:NE | --~ LEPEi8..8 giiedintigi iiafE isag 1E8E.. g33 cunneene dddddddagdnavis SITSIRSLSANARAY LJ p EY EE 24 i Sisdiiiiidiiags 5 LF oeeencninaeenas i ii : sEdERRazianiang g i iiia, 35s i ii:.a7: a35553E539 ||| " i:.7: saBnRaEgE ||| i 1 iEiidiadgiRsgazdEaanzge Pli5eyd - 3ide 2538 ] b-i ms - 255833 i ; ; - sigssEs ~i EERE EEE - od 2 =i EHH :2 ir sana 4 iE Hy i338 ~ | 1 islss 2 iad iiis,t #13 i 3888 ig i sic i ~ 54 SH #2 gEsgsrganmaas i i ~~ 3d i IEaasesEasisEes 3 yYo mmuminmm :8 ! i i siiditiiiiang : 1} mam iif Z #.3 iyi 338835ggEREEsss i Zsgssrzsnssseas 5%d bo | Rm ERREm RARRm REAN B2 oftp lnm ! 3 8 3 ER rvs 8 2 EEE 3 i annee 8 2o7 g2388 2 i? or i ir g5ics i 1 --~ 48 Roirfvaednicdeanaedviiivaa:n 1i o:h mgiEoganmedamnizaeis Yo nanmnnomn Ht IRANCATINARTILE . auenqaeerevaas 53| 2: .j , seRaARfEsmAsgEEERnIeistEIeEs 3 3 oi ~ ERE HE ~3 32 8 = g3saE 2, J 3 2 gage 2 $d g i. eens 3 3$.722 FsLeEnReEs 5g [Ed agdaz ii iid iiti, eg8sEadsE i?2a] + iE . LH 24] 8 "3 ie g or gesde 5353 HeIRs g [4iJ Hi . ss f: ;i jiigiiigdacgiesgnngisseiggaiissgsissiesy ]z 4_ gioEeacvEeEsEnssaaanaRcassoneeasanaadat !! i 8 } :I3 BnSgnagNRgEanLsgIRRRISmERaRangEsGY ] ~~ iii :3 1.0 giBnEdLiHiEdSeUeCcIeRnIiRiEiRiIsLnAaRiAtRiLiIsE $i 3i. mIdmimEmasiimdaiznairzaensiaenaisnsag i,.i gqaedosRnfdcdsaidsddeisnzdaaaisiadiiaidiniainsgamnniiz 4 i IRdRdidaniaidndniaaanad i 3 3 NRRRANKARRR3ASRARRAR y 3 ii :Fafrddsi dats dadsiensa dann dngs dan ~3 iL 3 ia BENE i L[RRe Sas d3istgazesd 2pas !g fe iI :3 8373R253238 43% 11 jLepo mBHmmmEnmnStmnsemd ain 5 2g BF ognonosasiscigesiiness ews i ~~ g2 3 3 g i: EEE 8 IE ; id mu ! if or [iEtE ess " :i 3383s iE 5. q3 7 = i or amoe g834% mE oat 3 a 5g I,. EeRzIeGsEaCnEsSsEvEsRsRoAnSeSsIsRiRaRiEiRnEaNsRsE 3 i f i REREEERERUATAREARRRARNALY i sRasRRfyRdesasdaasideges 2 2.0 gizefsdsndgsssiddddsessds fa i .8 $i 8i. geazsgEaRsssIsnseaRnRdsddisnnienanagnsddaaRd sSi9svgsduzeinieinnadvnssidyaadnagdnneecsaanneass LIo IE uEEEIIe GLRER . eamenencnsnnsasiacssasass 24 fo; fRnssdREissssnsadigsgeiss 4 gl .ig i8%. ii :% ssrissnseassssiioszfsiesigsaaszdasnaadseanndcaass -3 fa Shs i Hise gsannzmisadsaddangnieg Ii fs nan ~ $2. ayraseesnasssienssansieens ifs $i 8i. s gagao ssanm gatao zaiis nsnd: aads Fl FoF ozmmoeenererenesaaniienn i Hr : HBARRANRAGCTASRSARNRGIRGE ~3 $ z ia7 Hiidics i fisz 3033s i i3 as3t i HA 3 i4 Hi [3 FS i 5 H --~ 34 5 Pa ii 5 # 3338 ~ 3i : 3 FEEEN ! . ssensasase i Yo npmum pr om i So nmumnn $2 KRRRREAR j : IR iid $1, 3i samen 2RRAREARNT 1 Hmm ig fos ~~ 3 2 i ; ii i i 3 i i i 31 i 37 SRAH33R33R .5 gasfgeddEg 3 z. 2 { EI Boa. . 8 ghgisifsss ~ 823 z z . qoanesaucnases 3 if i $1 RRENARRRIARRRAR : i12 BsitnaNunntm ! --~ $[R4C,E stHrC psgH eemE esnE ens iif SBEH a ~ i4 fBoop F= osnEcsmdadnearneesndeRnEnss: i 1 RggigEzEgsaEsszaaisEaanessaEs ~ og 1. if ia aavn 3 33883 ig saves i: En ii or ~ i fo mmr FI Fe ddddsenazandad ye i gszsAREgazaRasy i i 0 :F EeRcanRasnEvReaaEnanRnEsiaany 3 5 3 3 3 f i ~~ 3 g 3 1 358 : i 2 82d iiF,"i2 iEsHiH g]|| id sigs fi F E.7 F$EiLdEaHs ES 4 2 2a] Sadie r igse i ir 38888 ~4 i Hi - HF ARIRSZIEREAATRR ; fjep AR disdsdasdaianay f 5 Em ESRESRAm RARRASS i ~-- Pi ii, mE aan anain 2 Z 00 rgd fe BERSRARRERRRERS Fidgnsaddnasads ~3 x 2 3 jye TEE Ape bes mnmmn ~3 EiH F1ag3asn8n i i i fis? FEE or 5 } i Hi i? or pie is, 313 5 fad sggds & ii is oa it or i fa, wm 2s 3 nomen ~ 3 z by S EE IR IE A :i "4, cBoitencas i i:i Lo suonnamimaas i 3 #8358d8gRsRRInaEERERE # !i3 " fiiiiiinnaatasanaanns 82 | PHEhe Sniinfdmidmdanidniamnsninaannias 8 iPsl5.1 o4 sEmHmHnmnmuHnEnH i fHoe mSiandmmemimoon 5+ iogis EEREER REFEEREEEFEERIE "FEbit3 rHainte A dn eaia ~3 3 g i i if 3 & ~ 1: ZImmmmmmsssesss 5 E 1i 5 , sAREoINvRAmNASmRNmERnRAnIRAmNGaE n22 Lo momEnRGuSsE iz pronnEnnonannassnonnan on q] ie EnmEHEGLEDG BR FY i DoF Hr 8 BnRIuRIoRImAAiRLNiNAiRAnREaRAnRE 2u2n ~ 23 3 iif? Hi 25 igre if or t5 s2 ia3m3adn3 3 Hieq 23 355 42 said 31 ii i5 188m88 gd 5i,a - Fe 23 z Fran 2 Eo F HH [ 22 EI Qnnes gagsz 3 gg 38 52i 5 F } H9:02-4D6a7y8:OraSlubGeahvraogneicStTuoxdiyciintyRats --~ DuPont6554 APPENDIX D INDIVIUAL FOOD CONSUMPTION ~~ --~ eee ------ Company Sanitized, Does not contain TSCA CBI 9H02-4D6a7y8O;raSluGbcahvraogneicStTuoxdiyciintyRats -- INDIVIDUAL FOOD CONSUMPTION Study Design EXPLANATORY NOTES DuPont6554 MaleGrouFpemale Dosage I I Omgkgday mM IV 60mghkgiday V VI 10mghkglday VIL VIL 60mgkgiday IX X 300 mg/kgiday Test Substance Vehicle control Isopropanol control H-24678 H24678 H-24678 Critical Dates Day90 > Lthaestondea-ymoofnttehstasnudbs3t-amnocnetahdmrienciosvterraytipoenrifoodrs.male and female rats designated for Day91 > eLxasptosduaryeopfereisotd.substance administration for male rats designated for the 90-day ~ > Rreeccoovveerryyppeerrioidosd.begins for rats designated for the one-month and 3-month Day92 > eLaxsptosduaryeopfertiesotd.substance administration for female rats designated for the 90-day > Male rats designated for the 90-day exposure period were sacrificed. >Maleratsdosed with isopropanol (Group IID) were sacrificed. Day93 > Female rats designatedforthe 90-day exposure period were sacrificed. > Female rats dosed with isopropanol (Group IV) were sacrificed. Day 122 > Msaaclriefiacnedd.female rats designated for the one-month recovery period were Day 183 > Male and female rats designated for the 3-month recovery period were sacrificed. Note Unless footnoted, absent data indicates animal was not alive a the time of data collection. Footnotes a O3-nmotenstthdareyc8o4v,erfyo.od consumption data were not collected for 5 rats/group designated for TT -------- `Company Sanitized. Doss not contain TSCA CBI ~ 3 : 1He a EERIE ii i EE EELS i i 32 23 Aid anena anang fm nnmnnEIIEs i i _ i FERIRFORRUERRIRSERRREER Sig sammieassnonsanteeecesess " Pi adaddnddddndsandnddnagsag it Bin fli re e reeia nnam ssngn asa i 33ERAAscRERASRERIAREANERS Ai mmsmmmmnaans homin, semana 5 ~~ Pd 8 3 ii 3 2 3 i: ih IIiaEnT 8 I 5 33 Pn 558 g8 8 ~ if FR iH RERAARAARRIARA i3 ij naan ji aBis c AIIIRNImGEIESEm gBni EE ERIE gar Foon gmessecesssraananes gg B UOT ROSSASRSRSRARRIRARARY | spesERRififdffinanie ~ Z| Hoim mms : 3iB EERE 35 ii aassdsdass i i mms 1 jg ~ | tiBk: mEmEn 3P8i: aam dam ik 83x Fisiiessis Hs Enns 1=s J OY 9 aqeFanaa gf To - g3 | 3 & 3 2 iis f ih 1 33 i ~5 a 518,3s 3 18 HE, 3h Be mE ii f3 il88ssB RRaRRIEEE 1i E t i La ~3 Z| 1 sasuans ji 8 i i 595 dhfddsdssssssss Ee fis mainianim 2 fe i mmmInnm i i Ci mmanmnEEm _ iagl 38He aGAnRIpEReRRInEEEannEAETnEE ; 1H ii PATOh ERR ich Tal TTT Heo mmm ih of i 23iRsRddRaRdaad HL i He F2H Biz w2 4aeRqAqEquRciaEvNeaEnEamnmn ~& BEER rm 2 ] i: 3 i ia 11333 i ih ' fy PEP --~ iil l 3gE i fain I 31 3 fis $3328 fe mmm i 3 ae sme: aoa, Pin fnnmomeianin ~i BEEERESRIEEEENE ~ ig | HI HfiHe 3R3R3AdA3R%A3RIRERnRIAiAsNEEs 8 ie: ESEiEgEgEnEnEnLnEmReEeEsEaEnEe i: i : f3sH FFRiAlRiA3RiAiAiRdLiRdAeRnEeSa :i i i HHsh EFRRa3R3AiSSAERaRaREARAiReANSs :: _ Hy5 HiH HpiR SasdgasssedRaadnnadtsaandnass mmmmEnE ! ' Fjii FmEsaARSnARnARAaRAnLH $h3i: 4g2iRmRSAiREAnRiNERiAiEvRaAnR: i2 jBiin ; 3R3a3R3RE3A3R3A3R8EA0A5Z8A i i 3 3. :FEsEaEsEnaEtEaEsEEaiECiEaEiEeEnS ~~ 3 8 i i i in sana i I ji irae ~ | tik j1k 1a ij i333 Be } fin Faigaa3aiIeacay dB mmm 2 35% BEieEI ramos ~ : i FRAARERIINAAARRNRER 3 i FERRrrE ikn mhE E i. iis pG ouEER in | ~ 1| iish mFoARmRAReRAnRARRARARRAoR AoRS || :1 Hi E EaEnTnEeBEe XLEY iih ShnsRETRienEasne ; fe EPH REM rRREEArRhES | hio WH,5 SRARARR RATA AR RFAERdAARRs .: i EEEEEE 3 : 8 3 5 H E 2 3 3hHE S3addndaaay ad i I 1 fiz Gann a ~ | ta 3 E38 : 3% i7g 3H Bie AB id gry ili o fAsAs8s8RaR IH% EFIEFE FOR pumas am smmnaemmm om mmnmEI EEE $ ~~ 2 32 legs dnossssararndsssosnSn k : Be EInRETRRaEN f 2 i Biz Jinsncaancuanansnssancmas 8 iy, nneneseneescscaasaedtadna 3 H 53E% KGERNNSSIANNSRNAGC RTBARNAAARRAANNRAZGRSRAAAISR I ~ | gi i 38 18 jib fi i Bin EEEEERIRRRRES EENRRIETRI amRuREIEERR InnesscensasseavaagIdIz: 3 I: Barmy 18 fn oan i23 Bize" Crm ~~ 2 i 8 i i gHae SE8n9ianEngINae j ~ | s1i1sk IIIT 1k nS 51h ii i EET Be iY anmInIIEEELH iJA oBls ammonia $e in 5 4 Bic F Riis enansssanazgsaie: 9 Yi SNESUAnEBREREEANTS ~~ 2 j 0 saad ; gBEi ;S Be munnm : iH : iBe mEman & ] HY8$33:% Sdeendaandmdndmanded 4F Es mma : ~ {IE L 3 is Idan Pie mmnnn i HBey aman 32] 3i38,s 8 aimEuEadasnEnEeEnssd i 5 AREER i : g 5 i 3 3 I 1 PO 5 Ba i ii 51k if 83: RIigEsasn: Hy How 2%EE ER : EE MEREARE 23 Bizhe sTF oE eooznE ecaue - 2 i eeennemneangens 52 Iigipsiniaiiaie 85 i [PEPER i : j HFwi aRaaiaEEEEAAM 3 3s Iaiaaasnaanam ' 5 1 3333738d80aaR8 -- i ! ifs 3d3i3d3%R3d3d32d3a3n33a%a2 iiio assssasass iHe Fn EAIEn EAAIAn ARA i i 3 ddgagdndniiadas i a i. | mannan i v 3 i ' 3 js 1333 i ~ | 5Bijkz i3aa7 L 3 is sas " Be mmEnmnng i J iE mmm FH ine Tononimimanion goa, iA.i fe aSmRsRdsAssaanas u - ARKRIR i REdddiAEARAAEE tf&rs i33mdeFaRdARRdaasgaR~ ana || i AEAREiNARARAN | _ |i i 1SdoRdeanEianEs | 3: H3iFa FIsEE i} | fiin oRmEERREIEES | ; iis . F. NeiARARdAdEEEAEERNE i ii;; : Sum Fa2iddas Ri iLh:EE3aRazisani ~ 3 3 8 2 !3 in 3a 1 ii giiil FEiia : FRE iidEd ji ii FREER 1 SBE pam E. mma He I8 $i3n: HE jimiisianiiias: ~ Z| : Ee 3 3 Be mm i 18 i 3 EL i 14} i Be mE 3i2 :] Be SmEEIEIINING ~ | 1iE Hiiis EIILIEIENT i $Pi0n mmmmssmnnnn 3H 5: InIEnILIG i ie smmmmenaminn Fl gli 8 gy Formmasmsasaasssseeences gf Bo 3 iz : i i 1 i BunNRGs : it 1 HIE i 5 ii: Ii3isanaasaEs I - fil So 3H iiis iiiiaEiEEEEm iBhe maskin BJl oBne mmm mmnns i jit 3 AfRSASSRs And ddsdssnsAds H902.4D6a7y8:OraSlubGcahvvaogneicStTuodxyiciintyRats ~ DuPont6554 APPENDIX E INDIVIDUAL CLINICAANLDANMDOROTPAHLTIHTAYLRMEOCLOORGDISCAL OBSERVATIONS Te,-- `Company Sanitized. Does notcontain TSCA CBI 9H02D46a7y8:OraSluGbaevlavgoeniStTuodsyicitnyRats Dupont6554 ~ INDIVIDUAL CLINICAANLDANMODROTPAHLTIHTAYLRMEOCLOORGDISCAL OBSERVATIONS `Study Design EXPLANATORY NOTES MalGerouFpemale Dosage Test Substance mIM IIV O6mmggkkggddaayy IVseohpircolpeacnoonltrcoolntrol VVIL VVIID 6100mmggkkggiddaayy H24678 H-24678 XX 300mgkgday H24678 CriticalDates Day90 > tLhaestondea-ymoofnttehstasnudbs3t-amnocnetahdmrienciosvterraytipoenrifoodsr.male and female rats designated for Day91 > eLxasptosduaryeofpertieosdt.substance administration for male rats designated for the 90-day --_ > rReeccoovveerryyppereiroidosd.begins for ras designated for the one-month and 3-month Day 92 > eLaxsptosduaryoe fpertieostd.substance administration for female rats designated for the 90-day > Male rats designated for the 90-day exposure period were sacrificed. > Male rats dosed with isopropanol (Group I) were sacrificed. Day93 > Female ats designated for the 90-day exposure period were sacrificed. > Female rats dosed with isopropanol (Group IV) were sacrificed. Day 122 > Msaaclriefiacnedd.female rats designatedforthe one-month recovery period were Day 183 > Male and female rats designated for the 3-month recovery period were sacrificed. -- - Company Sanitized. Doss not contain TSCA cal --~ 3 fog FE] 5 3 3 Z |E 3 8 3 2 2 S 32 it iE 3 5fl i gl ~3 y2 jbiE:8 Podst T3e%gf:z dasd T3i3:; 431 31 df 3ii:: dil 3(4;: gid iofd3jdif2i3t3idefeiitdat2e3te2c3a4ga2n3s} F Frhoigigdiiidiqts dirii alrgi diaai itiaa giis est ffiredsiisiprirdaiiiigsiafioiisiiiiisiiiieiiasd id g i. 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Gi ok 2! i % ~~ P3 oy ii:5 $F PEri ls 24 br [HIE 4 ~3 7PodZiF eiii8gl%iigigtdy P1 old f i2d 3te,]0z A 3 ogN gsiS EdEanE dFsgRIESi4I8E8 % ig HS Peg d EERi EEi fEoEce FiEqEbi EbEeEdi IiNEI d iEdY ISERERREE EEERRR RRRINEE $i8ssseee 5388000080 85 28114 i583 gi 8: if 5... . . ~~ 3 z 33 2 i i . f i ] 3,isssfisesiTscreadsiesa.iaffoaxloni: n, i i P[Iod i i ii 2 1[I I PaToo5gi3 =fgiEi:gf aff8 oigf , py 2 3i83 i3 pod i 3813 3 S1ospf) 1irsd] idy: Doiibiby PeHdIyE a1y6d a1g4 tii Hi B; eiPlESi EREt GEL i iYiRPg iPiiPiYi iisir iiiis: 0EE dEeEIsEtEiRsEaElReElRiRiEaREinEiRsIbEiiEiRaEg 3 id8 i3 qifa 3 i2 3 :3 2 g5 2 :2 ~ogElose - - - ~~ 2j 3 i . zgi shslsasiscablan aa lfna.s i 3 2 i 8 Z 2 3 i i 3 iz Pop hp ban r~ 3 P IfHdy FPHas 4 TdHev 4 Tlo1l:i 4 TliHao 3Bofg3f 2fy%i ipiyfi 4op fpyiid f olyli i 8: 1: 1:8: i:i ijiif sS3 ooel33irslpisieli se2 ii:iaez drn2; iairieii ga2 ti ipr2ii g atsis eiif ii 2iaoi ndasdf l tg Jierdiiigiiagiigigiiigieeg afil Sfiifgdeicciedleisebziiefsiiiiidiiiagciieidnicfec i 138 3 i3 i ~3 ol O 9H02-6D7a8D y:OraSluy GbahvvaogO necSTtoxyu iciintyRG s ageSudyinkpDwe uopown.s e65s54s APPENDIX F INDIVIDUAL OPHTHALMOLOGY EXAMINATION REPORT Abbreviations: OOSD OOccuullaarrSDienxitsteerr -RLiegfhtteeyyee --_ a -_-- `Company Sanitzed. Doss not contain TSCA CBI || S9e0.Doay OnralGaGmave-- atgeuSlty-- diyninkReas oDuwpeomnte5s5s4 | NAEN6VC1Y1E9MMC.LABISRNSIOCMAFBCOEHRRUGA,NSIVEMATAADTLV.SES,MS. BETHESDA, MD 218i STUDYINFORMATION:Bnway Specie Rat ml, mam) Shady DisDtonDrell:er OPHTHALMOTLExeOatmGiDInaayCt:Ai3oL1nEaXtA:MIANAnTIg3O,N00S1UMMARY SMMiExeTHODS:InGdrvioruecpthO|phCSa10tpB0"estmofoFlFsOolboocwcsiircnrogriaa1tny%eetnsTddreoeppeiaeceearrmaitdeoennmy00i85asis Fede XW Foulrimalmenionp --_ cf0oerMmaapnlTEmehaN.rTieAStTehD)eIrtoSeirCbaUtaSlsdSownIeOousNgdlsoebfediuriewntignt.h)podpegtehrnselraomtobivsoicnpiionnesicoboos,,awsrhgoch2)6mparkoesssa deonnse. Nocomponadrelatedabaormalitsvere Bent. Diplomate, ACV:0, van wo Shs. Cigar ~ 3501 . - Company Sanitized. Doss not contain Tscacar H9D-02.4Dw6a7y8OO:rnaSluCGbrcahavragogneeiScSutTduodxyyiiciinntyRRaatss DDuuPobnt.o655s4 APPENDIX G INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS --_ _-- ee Company Sanitized. Does not contain TSCACBI H902-4D6a7y8O;raSluGbcahvraogneicStTuodryiciintyRats DwuPoonwt6s554 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS EXPLANATORY NOTES Study Design Group Male Female Dosage IT IM 1 IV Omgkgday 60mgkgday V VI VI 10mgkgday VII 60mgkgday IX X 300 mgkgday Test Substance Vehicle control IHs-o2p4r6o7p8anol control H-24678 H-24678 Footnotes 2 One ratdiedprior to the week 13evaluation. Abbreviations -.. Nodata PN -YY Company Sanilizad. Doss not contain TSCA CBI 9102D4a67y5O:raSlubGeahvvaogneicSuTodxyiciintyRats -- Dupont.6554 _-- emBASEaLINE INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS NAoNvomimbabetrr TeTrEaoOlllRlETLIaTMeBlGlRITPeSToTaeRlE3NGTMTHe(Trakongds)oesf Grow 1:0 mggiay TTaeH allllITTeNalGRd2D IPTL STrTaRI lEsNdGM THMT(TeB rkaogans)kof o"woine 006s 00m% 0o0msi oose oG5n0 00as o0sw 0oem @o5 0@ 06 oss 0os3s 0st Cmeote 00815 0os6s o07s1s Gn 0s oss os oome oss GGis 009s1 0osgs 007s6 o06es Group I: 60 mpkgiday spropanct 00129 o03s 003s oomx 002s7 0022%% 0ox% ooxm 0020 00129 0032 ooms 00%% 002m% oomm oomm 0o2n8 o0s7 0om% ooxm ~ wsrw 003% 00sgt 0os9s ooas sw 00 0m 0s ost 00247 0033% 0om ooxx 028 018 on ox GG65 004 0006 oosms 0os4 se 0a 0% om oes 00s3t 0032% oomx ooxx 02 02 om om wGw9 00s5 o0m4 oosm ooas G0 00 06 os oss 00220 00235 o0a3 ooxm 0% 0s 0% ox G80 0% 0m 0s om 09 0% os om Group V: 10 mikgdny oesie 00sm 005s1 o0ms ooem G"iess 00M9 009s5 0om6 "ws 01 0m os oosm om GG8s0 008%8 0050 006s 0o5s0 w"ssi 00%% 00a5 o0os eB 0s 0s os oowm oe 008%8 0022% o0us oomu 002%7 0on2 o02x% oomx 006250 00a% ooan ookm 00129 0022 oomm ooxw 0035 00223% 00159 ooxm -- -_-- CompanySanitred, Doss notonctoanitanin TSCA CB 5H02D46a7y8Or:alSGubarovniacgtTooexyiciintyRats DuPoni6s54 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALBEASRELAITNSE AvNiommable Ti[ElOlRELITMrBuG?RIPSTTaRuENGTHMT(eaknsgok)t P-- ssemz 00sm 0oms 0osm oosss msmia 00ss 00st 00;; o0ms ssiseo 00s% 005gs 00m 0o8m Gsms0o 015m o0ms ooem o0e% sGoms 00ss oonw oomn ooam TeH allITN aGaRD lIPL STToRI uEsNGM THM(TB eekagnl)eo o0is o0m o0sm ooax 0osl oomn 0omn oomm 0013s o0mx oosm ooxx: 003s% 003s oouss 0od3s 00ax o0mm ooim oons Group IX: 300 mg/kg/day ~ ssmmio 0onm 0ogw o0ns 0o%m 0opm 00a3 0oms 0033s ssomao 0osn oose o0mm oonel 00%x 0o2a o0m0 0oy ssmoso 0om@ oosm 0osm 0osn o0ixs o0s ooxd 0o2n s"omn oosw o0mm o0s%t o0e8 o01ns 00am ooax oomm Gs0o6s 003m1 0oos 0osw 0o5m7 0onm oomx 0ois oonx Pa ------gye ------e --------e ---- Comp Sanitzed, Doss netcri-- ain TSCACH H904.GD7a8y:OraSluGbcahvraogneicStTuodxyicintyRats --_ Dupont6ss4 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS - wes AnNuimmbaelr _ 'FORELIMBGRIPSTRENGTH (kg) Tdsll Tad? Tasl3 MeaTrnaosf HINGRD IPL STRI ENGM THM(eB kagn)ot Tall Tral2 Teal Tass Group 1: O mekaiday eGo2s 11m0 LLems o1e a GGosn 0190 1L1112: 1l2d eGi6s0 007705 011%s 011223 00s9 GGosn 1136%s 1l6e 0169s 1Le2s eeswls 21330 019m5 21261 aLins Group It: G0 mekgday sopropasl 00527 0ou2 00x3 o0ad 0032 o0es oossts 0o4a0r 0ou7 00%3 o03n% 0033 006 % o0s% 0ox4 0035s6 o02i 0ons oosst oosm sr 200 200 12 us 07 013 0 om ~~ 6o48w23n2 0l9e9 oss La 019266 10s 01825 156 0l9a3 13s 00325 0% 002585 02 0032%9 0 0o.4x0 oa oewmse L1sa L19701l3as 113706 00s%t 00520 00ss oosxt GGo0 018% 01mm o1ss oumm 00805 005:5 oossts 0o7ss eGs0e3 2142 113s0 01% 112906 0062 0osss oosms 00ds Group V: 10 mgfkgiday ccoo 11540 112g8 11m3 1a3s% Geurss L1a3s0 113m 1122 131 oossss 1122 1120 1L0e8 112410 eGs0l9 116270 1107s5 l1e8ss l1e4l7 o Gnsm19s lLees 11s 110% 0022 00s0 0o5a0 o0asrt 002g o0ms o0s ooasr 00421 00469 004%7 oosdts 00st 0053 0o5k1 oosm4 002%a 0os3s 0oso oomd _-- Company Santized, Doss not co~to!nTSCACHI H-24678;: Subchvonie Toxicity 90.Day Oral Gavage Study in Rats ~~ DuPont6554 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS WEEK 13 EORELIMBGRIPSTRENGTH (kg) AvNuimmbaelr _ Trial! Trial? Trial MTeraianlosf 'HIGNRIDPSTLREINGTMH (Bss) Tell Tral2 Trad MTeraianlosf Group VII: 60 mg/kg/day 23 837 11 156 138 121 0m la Lis Lao 3 00 G44 12 a4 124 0L2a6 0182s4 6259 oases 16 137 130 11s 134 123 140 125 G20 6260 138 180 08 109 008458 1L0I3 G00 124 e305 148 124 11s le 0s6 130 106 03 044 03% 03 057 038 044 039 004492 00424 003a0 004x7 037 070 050 070 060 05s 049 065 00328 005%8 00531% 00536 050 034 048 09 06 03 055 034 Group IX: 300 mg/kg/day '-- 30 236 os 168 0% Le - 040 0s8 04 op , - ees9a 1012 01%s 0179 01922 00838 0m 02 05 02 oa 02 om6l 158 ame 091 148 1st 135 079 La 108 033 030 0 02 od 025 0x 026 a7 6262 100 128 107 050 las 080 Lp 0% 045 02 027 02 os 03 03 030 om 4306 131 178 LD 199 2L0S4S 1139s4 00348 004517 00a3 o04d6 - `Company Sanitized. Does not contain TSCA CBI 91.02D0a67y8:OraSluabcvhrgoieStTuoxdiyciintyRats Dupont6554 BASELINE INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS AnNiummabler [EORELIMBGRIP STRENGTH (kg) Teall Tid? Tald MTeeaankof Group I: 0 mp/kgliay sGuosw 005423 00651s o0sm o0s m Gessi 003610 009%1 o0i5s9 o07e0 GG2s6 003%1, 00468 009310 00a@ ccsere 00364 o0am 0osg oosn 6ei8s5a92 00491% 006%1 004%6 00590 Group IV: 60 mig/day Tsopropanol 'HIGNRID PSTLREI NGTM H(MkB ega)nof Tall Teal Teal Tass 0o1n6 003% ooizs o01x9 0o3m o03x6 ooar 0032% 0o2s o02x 0oxx 0o3ms 0os2 0o3w 00m2 0o3i6 0032% 003x% ooims o0x3: ~ GG6s 00508 0osat 0o4r9 0osm 001%9 0o2m oous oosm $G06 00332 00465 00s4 00541s o0i%s oolm 0o1a6 oomi ooss o02s1 003s5 o0md o0x5:9 0o2s o02x 0o%z ooax Gciss0p8 002754 0035 004s9 00631 0o%n o0l2 o01x6 ooux GGlso 005314 0o3s 0o2m3 0o2e 0o2u 0oxa ooxn 0o1ms Group VE: 10 mpkgdny oosiss 0031 004517 0044s3 00s37 Gei4s 005419 00440 005ss o05u1 eassios 002413 0043%7 o0sds o04m3 o8a0t0s 00ss 006%6 00s8l0 0o0ss2 Ges8l3 o04m0 005da 003m% 003686 00325 oonm o0xs 0o3xs 00235% 002530 00423 o0s o02n8 o0z2 ooxm oozns 0osn o0xx 00m% o03ds 002% 0ox% o03y o0z3 -_-- `Company Sanitized. Doss not contain TSCA CBI 9H02-4D6a7y5O:raSluGbacvhvaogneiSctToyxicilntyRass DuPont6554 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS BASELINE AnNiummbaelr EORELIMBGRIPSTRENGTH (ks) Trall Tral2 Tral3 MTerainsohf 'HIGNRIDPSTLREINGTMH (Bkg) Teall Tral2 Trial MTerainsohf Group VIII: 60 mgkgiday Gsus 070 isis 043 061 031 0&2 0271 06 03 662 051 8368 060 06 096 084 093 06s 083 48380 06 48381 056 06L 071 08% 080 073 069 48001 065 43417 068 047 08 061 088 058 080 on 0d 64340 046 OSL 063 062 06 051 058 Group X: 300 mglkglday 023 03 038 om on 02 031 03 023 023 ol 0 02 03% ox 02 or 03 0m 0 02 03: ox 03s 013 027 0l6 040 021 03 01 035 027 0s 031 02 os 02 03 ox -- 66488335550 003540 008552 0044d5 004630 00266 002233 00224 00221 Gs39 075 ass 053 080 047 06 067 073 06 046 02 03 02 041 03s 0s 0% 6s78 100 G33 032 0@2 00 07m 06 07 056 02 025 0s 025 031 028 ox 026 68387 058 o4808 03 064 064 070 053 ost 0s 04 030 03 09 03 oss 03 03s 4899 048 43419 044 0% 054 007416 0064)8 001274 0022 oolx o01xs --~ --_--mm_ m------ _ m---m Company Sanitized. Doss not contain TSCA CBI 9H240678O:DraSluaGbaevhrayogneicSTotxiiucintRdyatys DuPont6554 --_~ INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS WEEK 13 'EORELIMBGRIP STRENGTH (ke) AnNiummbaelr Trial] Trial2 Trial3 MTeraianlsof 'HIGNRIDPSTLREINGTMH(Bks) Teall Teal? Trld MeTarinsohf Group Il: 0 mg/kg/day asus 173 sis 037 12 02 LB ou 136 024 o4g04 08 o8404 158 124 ISS 063 134 08 150 coisgss 01%8 L1m911335 1L17B0 o87 so ose 117 Le 06 13 02 La 090 648439 141 os42 174 100 LIL 057 124 099 136 Group IV: 60 mp/kg/day Isopropanol 0@2 048 066 031 0a 03 os 038 02 080 02 0s 02 056 ox 06s 00331 003m 00138 0o2m 06 025 048 048 055 03% 05s 036 052 073 04s oe 06s 0s 054 06s ~ oGassie9 110228 01906 L1I3D 106 123 047 048 0s 046 048 043 046 046 6644889%6 LLiez L10Is L10u1 112016 00573 027 oss 02 00 0: oy e713 Gime 057 13% 120 0% 08 12 088 03 038 0m 03 02 0 0&0 Gis 068 6809 099 077 058 08% 048 07 068 041 04s 03 029 02 03% 03% 037 Gsa10 103 ssa 10s 120 15s 1L50125124 00530 00239 0od3s 0034 Group VI: 10 mg/kglday oss 065 4866 075 095 120 080 093 080 056 oasya L Gs 151 105 080 01366 0L9al7 668340063 019329 019s79 009784 01838 asd 094 609 078 0&2 130 02 106 08 10S G33 16 oigal 109 L718 140 123 11227s 03 osl ost om oa 04 04 0m 005417 005%0 00438 o0d4d3 003388 0&2 036 051 0s odd 03 03 044 0&2 028 0s 030 08 034 003477 00535 005560 o0d4s -- Company Sanitized. Does fot contain TSGA GBI 0H2-4D6a7y8:OraSluGbcahvraogneicStTuodxiyciintyRats. DuPont6554 INDIVIDUAL FORELIMB ANFDORHIFNEDMLAILMEBRGARTIPS STRENGTH ASSESSMENTS WEEK 13 EORELIMBGRIP STRENGTH(ke) HINGRDIPSLTRIENGMTH(Bks) ANvuimmbaelr Troll Teal Tadd MTeeadnosf Trell Tau? Tid MTeeaansof Group VII: 60 mykejday oCsses 0a768 016m 1L2e0 0Lem eowmeos 1Us4e 1L3e% 001s 112x oGsm 019270 013d0 110B6 01 8s ees8o4l7 002% 0L6z 0114 008%s oossmo lLsu oLne o12g4 o1mp Group X: 300 mg/kg/day 0ose 0062 0o6m1 0o6x 0ogd 0033% 00sm o0x6 00s% o0sdi 0045s0 005s6 0o2d3 0035 005 005% 002s 002710 o0o3 00s2 eGs0s 112306 01207 0122 01s% 0022 00%s 0o0m o0ado ~ oesgs 1L0rs 19 LB Li" s 02 oL n oow on oosm 01s3 0L0u o1m3 ILnn 00% 00333 o0sat o0id oGm0y8 0182 0L6s0 00650 0096 00206 003%% 0022 o0xm0 GGig9s 0l0e 012%6 L1O0 0Lass o0i 0oxx oosxs oonm --_-- Company Sanitzod, Doss notcontain TSCA CBI 5N 0H-2D4n6y7D 8O:raSluGby cahrvoeniO cSTaoxyicu intRyasGugeswhinRpe DwuPeonesis54 -- APPENDIX H INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS --_ -_-- omens Sar es sonnet contain TSCACBM 9H02-4D6a7y8;OraSluGbcahviaogneicStTuodiyciitnyRats DuPont6554 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS EXPLANATORYNOTES MANIINP OPENUFIELLDARA ENA(TFREI EROAOMINN GSPASCE) APPROACH& TOUCH: "041%== innscoormmeaealasieodnscion Gunpsvayorstacks) AUDITORYSTIMULUS: 401== nncoormmaaaliegoancgieoanceiaotnr(iaantcohetpsor,ef1lidpcks)ca) TAILPINCH: a0 == 1= coemmomxaras(uegmsreogsvpoanersde(nsvcoc)talizeatidon, rapid uing) INMOTORACTIVITYMONITOR PUPILLARY RESPONSE: ~ DEFECATION: URINATION Abbreviation 01s= dpreenm 0|Z= psheeenn b= dames 015= spheinn +. Nodatacollected Footnote: a Oneratdiedprior totheweek 13 evaluation. _--_---- `Company Seniized. Dos not contain TSCA CBI D5H0DL-2yD4O6a7ym8O;iraGlSouGbvacghvraeognSeiucStdTuoydxiyiciinntRkyaetss DDuuPeonmt6e55y4 --_ INDIVIDUAL FUNCTIONALFOOBRSMEARVLAETIROANTSAL BATTERY ASSESSMENTS TT mMVme ie Bw ASELINEdawy NAunmimbaelr anApdpTrooauchh _ AStuidmiutloursy Tal Pinch RPeapsiplolnasrye _Defecsion_ Urination Group: 0mgkgiday awmins 00 00 00 00 1' !1 a 650no0 00 00 00 01 11 osmos 00 00 00 00 01 11 oowwne 00 00 00 00 11 11 s amiso0 00 0 00 11 1 Group I: 60 my/kg/day Isopropanal waon 00 00 00 00 11 11 . GGosos no0 00 00 00 1! !1 sowmnes 00 00 00 00 11 11 ooom 00 00 00 00 01 01 aPgre 0 00 00 0 01 11 Group V: 10mke/dey s oi o0 00 00 00 1 01 oGiosn 00 00 00 00 11 11 cGoomsss 00 00 00 00 !1 01 oI go 0 00 00 00 11 11 eamsies 00 00 00 0o 00 1' -_-- `CompanySaniized.Doesnotcontain TSCAOBI 9H02.4D6a7y8:OnSulbcGharvoangiecStTurdicyiitnyRats Dupont 6554 INDIVIDUAL FUNCTIONALFOOBRSMEARVLAETIROATNSAL BATTERY ASSESSMENTS Manipuaion BASELINE TnMotorAci NAunmimbaelr anApdpTroouacchh AStuidmiutloursy _TailPinch RPeusppiolnrsye Defecation Urination Group VII: 60 make w woo o 00 00 00 01 01 s"oou so0 o0 00 00 11 11 oowwess 00 00 o0 00 11 11 css2m0 00 00 00 o0 11 11 oasms 00 00 0o 00 1 01 GroupIX:300mefketday oo wn o0 00 00 00 01 11 --_ oemai 00 10 00 00 11 11 oowmse 00 00 00 00 11 11 wwoomn 00 00 00 00 01 11 ccmmoss 00 0 00 00 '1 11 --_-- `CompanySenitized. Doesmotcontain TSCA GBI 2H9002.4DD6a7y8:OOroaSlluGbGeoahvvragogneeiscSutTuodxdyiyciiinntyRkaatss DDuuopomnet6s5s54s INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS TT mma WEEK 13 EMeeAwm NAunmimbaelr _AapndprTooaucchh _ AStuidmiutloursy _Tail Pinch RPeusppiolnrsye _Defecaion_ Urination Group: 0 mykpiday ssws 00 00 00 00 01 !1 GGomns 00 00 00 00 01 11 6p52r60 0 00 00 00 00 01 semns 00 00 00 00 01 1! sessi 00 0 o0 00 00 1' Group: 60 mpd Isopropanol a snE)0 00 00 00 01 11 ems 0 0 0 0 0 1 ~~ 6o48s25e8 ssn 00 0 [J0 0 a0 0 00 0 00 0 11 1 oomn 00 00 00 00 00 1' aawsns 00 00 00 0o 01 11 Group V: 10 myfkgiday sssso0 00 40 00 11 '' e6i2n5s 00 00 00 0o 01 11 esmoss 00 00 o0 00 00 11 spsolr 0 00 00 00 11 11 aG2ono0 0 0 00 1 11 _-- `CompanySaniized. Does not contain SoA CB H902.4D6a7y6O;raSg lubGcahvraogny eicSTuodxyicRiintyRaets DDuuPPoonmte6s55s4s INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS WEEK 13 `Manipulation Animal Approach Auditory TnMotorActivity Pupilary Number and Touch_Stimulus _Tail Pinch Response _Defecation _ Urination Group VI: 60 my/kgiday 644283273 0 0 0 0 0 0 0 0 1 1 1 1 66445224434 0 0 0 0 0 0 0 0 1 1 1 1 664488225696 00 00 00 00 1 0 1 1 664488225700 0 0 00 00 00 11 11 664458330050 00 00 00 00 1 0 1 1 Group IX: 300mykglday 6442823310 + -0 0 0- 1 .1 ~ 664488220419 0 0 0 0 0 0 0 0 1 0 1 1 664455226612 0 0 0 0 0 0 0 0 1 0 1 0 64488221872 0 0 0 0 0 0 0 0 0 1 1 1 64488320864. 00 00 00 00 1 1 1 1 --~ _--_-- `Company Senitized. Dos not contain TSCA CBI '9--H0-_-2--D4a6y78O:raSlue GbcahvraogneicSty TuodxyiciintyRats ~~ DuDPuPoonmt-66S55H4. INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS TT Animal Number BASELINE Mampdein | DMowamviy aAnpdpTrooaucchh AStuidmiutloursy_ Tail Pinch RPeupsiplolnasrye _Defecation_ Urination Group Il: 0mg/kg/day 645346 o 648389 0 0 0 0 0 0 0 0 0 1 0 648394 0 648404 0 0 0 0 0 0 0 1 1 1 1 648425 0 648426 0 0 0 0 0 0 0 0 0 1 0 648427 0 648434 0 0 0 0 0 0 0 1 0 1 1 648439 0 648442 0 0 0 0 0 0 0 1 0 1 1 Group IV: 60mg/kg/day Isopropanol 648364 0 648369 0 0 0 0 0 0 0 0 1 1 1 ~ 648390 0 648396 0 0 0 0 0 0 0 0 1 1 1 648397 0 648402 0 0 0 0 0 0 0 1 1 1 1 648408 0 648409 0 0 0 0 0 0 0 1 1 1 1 648410 0 648424. 0 0 0 0 0 0 0 1 1 0 1 Group VI: 10 mg/kg/day 645345 0 648366 0 0 0 0 0 0 0 1 1 1 1 648374. 0 48382 0 0 0 0 0 0 0 1 0 0 1 648403 0 648406. 0 0 0 0 0 0 0 1 1 1 1 pr 0 648429 0 0 0 0 0 0 0 i 0 1 0 648433 0 48441 0 0 0 0 0 0 0 1 0 1 0 ~~ m _-- 8 e Company Sanftized. Doss notcontain TSCA CBI 'H--9-_02---4D6a7y8e O:raSluGbcahvraogne eicStTuoxdiyciintyRats -- DuDPuoPomnts:6S554 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS TT Animal Number Mampi BASELINE Newey Approach and Touch Auditory Stimulus _Tail Pinch_ RPeupsiplolnasrye _Defecation_ Urination Group VIIL: 60 mg/kg/day 648348 0 648354 0 0 0 0 0 0 0 0 0 1 1 648362 0 648368 0 0 0 0 0 0 0 0 1 1 0 648350 0 648381 0 0 4 0 0 0 0 1 0 1 1 648401 0 648417 0 0 0 0 0 0 0 1 1 1 1 648432 0 648440 0 0 0 0 0 0 0 1 1 1 0 Group X: 300 my/kglday 648350 0 648355 0 0 0 0 0 0 0 1 0 1 0 ~ 648359 0 648375 0 0 0 0 0 0 0 I 0 1 0 648378 0 0 648383 0 0 0 0 0 0 0 1 1 i 648387 0 648398 0 0 0 0 0 0 0 1 1 1 1 648399 0 0 648419 0 0 0 0 0 0 0 1 1 1 --_ - Gompeny Saniized. Doss not contcor:ain TSCACBI 9H02-4D6a7y8O:raSlue bGcahvraogney icStTuoxdiyciiRntyRaets --~ DDuupPoonmte6s55s4t INDIVIDUAL FUNCTIONALFOORBSFEERMVAALTEIROANTASL BATTERY ASSESSMENTS WEEK 13 T Mapes T Meo NAunmimbaelr sAnpdprTooaucchh AStuidmiutloursy _Tail Pinch RPeusppiolanrsye _Defecation_ Urination Group I: 0 mg/kg/day 4488338496 0 0 0 0 0 0 0 0 0 0 1 1 664488340044 0 0 00 00 00 01 01 66448840256 0 0 0 0 0 0 0 0 0 0 1 1 p64r8427 0 0 00 00 00 00 11 6444844329 00 00 00 00 1 1 1 1 Group IV: 60 mg/kg/day Isopropanol 664488336698 00 00 00 00 0 0 1 1 ~~ 66448339906 00 00 00 00 00 11 6448s30927 00 00 00 00 0 0 1 1 644s5a400g9 0 0 0 0 0 0 0 0 1 1 1 1 6p454n10 0 0 00 00 00 00 11 Group VI: 10 my/kgiday 664488334656 00 00 00 00 1 0 1 1 66i485338724 0 0 0 0 0 0 0 0 1 1 1 1 664488440036 0 0 0 0 0 0 0 0 0 1 1 1 pn 645029 0 0 0 0 0 0 0 0 0 1 1 1 61s8a4aa3l3 0 0 0 0 0 0 0 0 1 1 1 1 - wm `Company Senitized. Boasnotcontain TSCA C31 H902-4D6a7y8:OraSlubGeahvraogneicStTuodsyicintyRs ~ DuPons54 INDIVIDUALFUNCTIONAL OBSERVBAA TTT ERYI ASO SEN SSMA ENL TS FOR FEMALE RATS `Manipulation WEEK 13 InN Actin ANnuimmbaelr aAnpdprTooaucchh A_uSdimiutloursy _TalPinch RPeupsiplolnasrye _Defecation Urination GroupVII: 60mghgiday sprses 0 00 00 00 01 11 sommee 00 00 40 00 01 11 Gawsms0 00 00 0 00 01 '1 sawowl 0o 00 00 00 01 11 ssmsn 00 o0 00 0 00 1' Group X:300mikgldny s63w5s50 00 00 00 00 o1 11 si350 0 0 0 0 1 ~~ 6c483s75 pore 02 0 0. 0 00 00 1i |1 ci8i078 00 00 o0 00 0 11 psosrae1o 0 00 00 0 11 1! --- `CompanySenftized.Does not containTCAcB D 9H0--24D6aD 7y8O:raSlw uGbacvhvaogO reiSctTuom dxyiciintyO Rats wigeSudyinRDDuue PPoonmtss 6s55s4s --~ APPENDIX I INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT -_-- `Company Sanitized. Does not contain TSCA CBI D 2904D6a7D y8;OrSau uGbaevharO goeicStTuom xdiyciintyRO ats _ uageSudyinRDDuua Poomnie.s 6s5s54s --_ INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT EXPLANATORY NOTES Footnote a. b. TOhneersaetndsioerddipdrinoorttaoptpheearwetoekbe13woervkaliunagticoonr.rectly and, therefore, the data were not used. Company Sanitized. Do--es--not contain TSCA CBI H90--2D4a6y78:OraSluGbacvhargoeieSTuodxyiciintyRats --~ DuPont6554 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS _Animal D BASEa LINEe r Number e SUCCn ESSIVEA 10-MINUe TEIINTRERYVAALLSS e eee: 1 2 3 4 5 6 Tou Group: 0mg/kg/day 648222126 u71s o31m5 218%7 210514 4 % 7 1 nue ne 64s5m23s3 36a5n 2 u2s sai 3515s us5 w1m00 649257 ce as 32 290 352 mn 32 0 a6 3 5 2 a 802 ws 648264 48271 an a8 us 384 259 26 7" 109 35 2 0 4 me na 664i5s237118 asat0 a6s3 33m26 2065 2695 nBs as1s0 --~ Group IT: 60 mg/kg/day Isopropancl 64458223227 as 62 a3 Ea ass 21 18 333 561 2 0 uw ue 645252 645258 3s a 318 1we92 12988 3s1 33 1909600 645269 48274 bl 63 330 a2 3m1 o2m7 960 o78m8 664458229090 aaa 05 327 357 165 333 2 39 o 7 10 5s 966 46 648302 645303 us 38 29 us 273 ur 183 m 2 2 Las 1 Group V: 10 mg/kgiday 64as5222214 3s 6 am7s m6 13s @ 0 9 0 uss 545 cas245 648273 2mwse a0 0 9 om 217 106 13 16 nis 1500 6o45i28s6 3a0s4 220518 w6o 3 0 om 0 3 as 20 64301 648309 an 28 366 25 2m 64 ms0 4 2 uonno a sasai2 6is313 04 a 20 x 0 187 2 2% 184 3 vo 1 910 - `CompanySanttized. Doss notcontain TSCA CBI H902-4D6a7y8:OrSaulbGcahvraogneicSTtouxdiyciintyRats --~ DuPont6554 INDIVIDUAL MOTOR ACTIVITYFAOSRSEMSASLMEENRTA:TSDURATION OF MOVEMENT (sec) _ Animal eBASeELIe NE P ---Numbe er i eewlMi `Success sive 1e 0-Minul te Intew rvals ends 1 2 3 4 5 6 Tow Group VII: 60 mgrkg/day 645223 648237 w as ma 364 184 2 2 65 13 68243 cna 383 aa 37 an 154 336 0 388 7 m cans oases an a2 3a414 189 0[3 ss1 620 648280 3w 0 m263 32163 2a1u 31487 645300 648305 an 363 35 2 25 m 28 0 164 1 2ER) us 3 2 934 1676 1190%0 3sanes 6 8 um 883 Group IX: 300 m/keday ~ 645230 cas231 an as 253 ao 220 1709 72 rI n8e2s9 64488224419 3a60 penm 3086 an3 10 2 a 855 om 664455226612 a1is 326m6 E 360 T}25 510 [5 AT 1st c8277 45282 401 3 323662 32418 2068 1677 w0 el340 64488320864 399 3a16 32s 2053 1548 61a1m60 --_ _--_-- Company Sanitized. Doss not contain TSCA CBI H902-4D6ay78:OraSluGbeahvraogneicStTuodxyiciintyRats --~ DuPont6554 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS WEEK 13 NAunmimbaelr S`Sue ccessive10:MMiinutee lIneterrvals 1 2 3 4 5 6 Tom Group 1: 0 mykeday oie 645222 a 36 a om 03 28 ES 169 335 24 mw 0 an 10% 645233 sis0 344 a7 104 a7 160 av 126 om 61 on 155 23 950 210 025) 648260 as 34 3m 09 mBo190 179 10 0 1604 985 648264 o4s271 = 456 33370 6369 31s"6 2268 2040 o10n9s8 664485321718 a1 an 7 Pd 3ss 262 Eg 9 59 w 20 m 481 Group I: 60 mg/kg/day Tsopropanol ~~ 6p1r52e27 aa0 2Mw 201 2260 a8mmoees 664458225582 r3r50 321 22148 3113s8 9o1l 0 3 10s ue 645269 sis27a a ass 365 56 3 x 308 3m 30 208 3 20 om 205 om os09 an 410 31 341 m 306 e193 x 21 571s on 66448330023 H3963 310 330s9 2M18 om102 u 2 s 150 Group V: 10 mgkgiday 61p5r2e21] - aaa os 33 as 645286 645288 3a6 664488330019 3E1d 615312 648313 a6 362 0 . . 8 . " 2356 75 2201m 22068 326- 16. 8. 21. E3N2 32031 21596 1u9w1 23 25 @ 306 301 134 218 21 . 20son163 w2t5. i1so7s- 007 u16e4 26 5 1796 nos --_-- Company Sanitized. Doss not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study inRats -- DuPont-6554 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS eT Animal --_Nu--mber 1 Group VII: 60 mg/kg/day WEEK 13 w`Sucecesseivel1O0-MMiineultemIentreravlalss 2 3 4 1 & Toul 645223 645237 443 413 354 266 356 286 328 265 306 204 317 188 2104 1622 645243 363 645244 64 21 389 239 349 29 21 101 367 310 175 1484 2054 645259 417 648266. 443 381 369 300 335 331 346 343 286 118 25 1890 2004 648270 645280 374 453 316 315 258 301 25 277 1m 266 145 213 1515 1825 648300 400 324 309 648305 376 330 409 78 2 35 25 3 ne 0 ns Group IX: 300 mg/kg/day ~ 645230 645231 416 > 2 - 365 - 298- 284. 162- 1847: 648241 442 645249 462 44 349 337 25 391 296 292 281 12 13 20110 1633 648261 648262 399 352 351 265 319 239 341 31 23 6 53 1706 0 893 645277 645282 a2 354 34 306 366 Ek] 256 260 254 183 3 202 1855 1610 648284 36 648306. 341 320 284 271 321 27 175 299 250 1750 0 15 1136 -_-- Company Sanitized, Doss not contain TSCA CBI D9H02-4oD6a7y8mO;raSluObGacahvvraiogngeiecSStTuodxdyiyciiinntyRRaetss PS DDuuPPoomnets6s5t54. INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS --_-- Pc NAunmibmaelr kBAeSELINE I..Su. ccessive10c:Mdinucte IntervalsAE 1 2 3 4 3 6 Toul Group II: 0 mg/kg/day 648346 64838 a 3 ES) 179 n18o7 2u1s 1m55 645304 648404 381 03 203 29 24 17 75 29 183 254 casazs 43426 ats 6 an 216 254 2 26 au 109 286 644s8a237s m3n0 27986 210331 2To0l no 0 6caasgaa320 aanns 1E3n6 277 229 10 0o6n 1136810 a7 03 un 13s w 2a ena 7 6 ns 866 Lists ro nos Group IV: 60 mg/kg/day Isopropanol --_ 645364 648369 453 344 36 25 203 254 3 9 as 1 2wo1906 648390 648396 34 334 Mam2s w5s7 216m3 0[a Be 64397 648402 ww EIT B40 52 1 a4 125 as as 3 870 48408 648409 358 204 21 27 29 257 2 78 176 mo 19 es 18s 6o48s41e0 20a48 a2148 2a2m 355 o36u w2w 7s 2m Group VI: 10 mg/kg/day 6a4s533a6s6 uw o w 139 183 2187 04 167 nl 00 1s 1388 64m53e74 awm0 2315 E15l7 22956 197 91 D4 05 106 1528 43403 648406 418 a8 203 391 165 365 23 262 201 29 24 nm 2069 pn os9 3s 23 359 26 31 178 27 310 145 147 ET mo 13 p6e434t33 3808 3a0s4 71866 020 152 oa 2 1s 0 EEE `Company Sanftized. Does not contaln TSCA CBI 9H02-6D7ay8:OraSluGbacvhargoencStTuodxyiciintyRats --_ Dupont 6554 INDIVIDUAL MOTOR ACTIVITFYOARSSFEESMSAMLEENTR:ATDSURATION OF MOVEMENT (sec) --_A--mal bBAe SELINE SNumw ber eoes1le2lSucO cessi3vM e10:Mw inut4ee Intervl als 3te6ns Tal Group VII: 60 myiaiday oeumss wae oGmmse 3m oGmms 12 essolswas sossno 5d3e GrouXp:300meaty 030 a3em om w m2 d2e w 214 an3 1135 s1i4 2 mus ossope e as smwie w1s0 dae3s wssw ao2m 2as aBso 2Bma 2s 6 nuess oom esom MEs RYbo aume 2mms --_ eossws30 os ss 33% os m314 a6 aas 1 abss 3a ale miem 6 26 oessss es amm lma3 6a 2w0m am 2u0s me aom 1m aL me Tne wm sw sGaEgTs o9 m 3 ams8 mm ps 218m ow a2ss am le3 dewws 3 nw esis we 39 30 am us len ~ _--_-- ee `CompanySaniized. DoesnotconTtSaCAiCany Pe H9HD024Dw6aO7y5u:OrlaSlGuGbeaevmvaoegneiscSoTtonxyiicniktyReasss 0oDwuoPowneegs55s4 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS _ ial WWEEeK 13s SS Neumbee r elMSucceo ssive 10w -Minuts Ie nevals lws 1 2 3 4 3 6 Total Group 11: Omgeday oGsss SES was owae 30 2s wome 25 ama1se ao ms mg en ie a4 la o oessass s omsE a ddoe maomw amaem 34 0m1m leass am le lee G" s8s9 sawa s mB ds am108 2as4 oal aes a1mm In llasg leg esse am ms 1s as 1s le Group IV: 60 mykgiday spropanct -- oesses was "E030 awso om wssu ss wmee aaiss ous asme agsens am on 9ws6 "sR d ss wsn as9m ao ms mas ie awns 9 saem giees 1s ga SG8M0O8 emo d3s0s a26 mus m3s oan 2ow0 ml 2m s mIn vos ilees on "ss ST m9 a0 a0 as as see Grow Vi: 10 mpkgidny Gewuess se aa0m 03 aomm aem a6 m am se m wa0 amss ppws 0 ise Gemss oss awer a2 mam6s mo sa s mswmwar wm a0 1s 2 obmo lay o eessan s3 sa7 awem do mis seio me om a0 doios so am GBs wen 29 m0 as 1s 1 J ry ------ 'H9204-6D7ay8:OraSluGbacvhraogneiSctTuodxyiciintyRats Dupont6554 -- INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS NuAnmibmealr WEEK 13 `Successive 10-Minute Intervals 1 z 3 4 3 6 Toa Group VII: 60 mekeldsy eeissaisse oessmes proeiy eiesai0rL cGissis0 as os oa Mas3s aolw 26 2a4m0 3s aawus aass d3e 258 le 3U18 Mam6 e2238 2o m e25 83 2o9m 29 a202 361 0a9 3a8 2637 2I0s0 14 u1m8 wa9 owow 2 I1s6s% 2a0 2196526 Group X: 300 m/kpiday --_ eeaassrss0s 4a089 204 21580 1Ie 1996 a132 lueml 65350 : - - - - . . 6c8a3s7y5s 3> 23- Ie- 29- 21- 20- 160- ceawmssy w2s am 2a80 212 19720 168 1B78i4 ccaasgoos a37s 334 22M0 2 18 3136 B4 onnem 6519 > - -- TT `CompanyT Sanitized. Doss not contain TSCA CBI 9H0L-2D4a6y7:OrSaulGbacvharogneicStTuoxdiyciintyRats --~ DuPont6554 APPENDIX J INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS --_-- eee Company Sanitized. Does not contain TSCA CBI 9H02-4D6a7y8O:raSluGbacvhargoenSiuTodxyiciintyRats DuPont6554 -- INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS EXPLANATORY NOTES Footnotes a. The sensor did not appear to be working correctly and, therefore, the data were not used. b. One rat died prior to the week 13 evaluation. --_ --_ = --_-- Company Senftized. Does not contain TSCA CBI H-24675: Subehronic Toxicity `90-Day OralGavageStudyinRats DuPont6554 -- INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS NAunmibmaelr 1 Group 1: 0 mgfkglday BASELINE `Successive10-MinuteIntervals 2343 6 Tow 45216 193 135 141 120 152 645222 141 136 132 1s 103 664455225303 113067 112499 11635 13392 12250 664458226507 15514 1147 59 154 1 4 a ia 664455227614 11110 i2st2 113641 71 2 645278 112 a 131 137 Ed ca8311 106 24 139 159 148 2 703 8 615 o6 5213 3 329 52 558533 0 am 7 652 is oot Group I: 60 mykg/day Isopropanol ca827 123 139 123 1" 2 6 an --~ 664458225322 111491 1u3s7, 116315 11533 20 oss 2 04 48258 18 129 17 " 6 % an 664458227649 113347 11505 6 1s 5 m 1s 165 [ 3 032 664485229909 13424 21417 102 153 2 2 1 5 1 379 7 502 645302 648303 115417 115s1 15113 112052 31 72 56507 Group Vi 10mg/keday oassa2n2t4 1569 185 2 8 0 1 1 a 235 1 20 6i42824753 m118 2129 2w2 17317 51098 4] s3m8 645286 127 48288 [3 2579 1226 1400 30 271 71502 64530 141 645309 120 140 192 140 150 16 113 5 38 0 EY sa 02 645312 11s 648313 im 31530 113180. 1391 m2 165 a6s6a0 _------ Company Sanitized. Doas not contaln TSCA CBI HL24675: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont6554 -- INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS Nu`Amnbimearl BASELINE `Successive 10:Minute Intervals 1 2 3 4 5 6 Toa Group VII: 60 mgikg/day 615223 124 139 137 6 3 3s an 661455221337 1282 114511 108 103 32 02 495 7 381 615204 102 130 1a 126 8 6 588 661485226560. 12016 119a0 113206 171 1453 88 4=03 664455227800 116511 114444 113695 21528 13364 235 76589 648300 151 158 137 130 119 5 704 618305 12 3 na 3 7 15 383 Group IX: 300mg/kg/day -- 664455223301 113637 153 160 7 8 102 3 n 5 5 67 6a 66445224419 113227 113298 2 m 4 150 0 25 376 n 2 33 645261 125 3 131 2 0 5 20 61485226772 113294 19544 BL 11s 17 as 155 191 3 sis 856 645282 458 114398 12413 1335 r58y 5110 51 456018 648306 149 155 102 1 104 2 7s = -_-- Company Sanitized, Does not contain TSCA CB! HL24678: Subchronic Toricity 90-Day Oral Gavage Study in Rats --~ DuPont 6554 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS NuAnmibmaelr 1 Group : 0 mglkg/day WEEK 13 Successive 10:Minute Intervals 2343 6 Toul 64485222126 n16r0 112463 114353 115315 1396 22 676572 64233 645250 116008 12904 1294 110267 a5 114332 E8n 645257 139 645260 ha 1s 127 163 147 139 136 9% 9 58 780 1 553 664455227614 118s0 1m27 165 136 158 129 m 101 137 % 950 707 645278 648311 111008 114009 113532 2n7s 167 21807 379 Group TI: 60 mkgday sopropanol -- 645227 124 645232 144 2 147 110 149 11m41 91006 E8d 67854 661488225528 113364 112405 113239 13753 38 1022 85245 61488226794 11453 1B6l5 118902 1m34 1m 153 144 60 897 908 645290 648299 24 14 108 152 9% 161 133 12s 21 134 104 58 2 7 648302 648303 151 159 150 143 138 155 101 144 9 130 143 130 754 2 Group V: 10 mg/kesday 6421 - - - - . - - 664458222454 113394 i1s0t4 110522 191%6 35 128 7 162 2 88 645273 23 648286 136 191 136 19 21 113 50 12s 128 134 136 m 0 648288 - - : : - - 648301 648309 128 13 14 125 110488 113363 112296 12&6 78168 64312 4313 138 24 130 ns 138 128 nm 8 % 1s 22 30 746 84 ~~ _--m_--------Company Sanitized. Dossnotcontain TSCA CBU 9H02-4D6a7y8:OraSluGbacvhargoeicStTuoxdiyicintRyats DuPont 6554 -- INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS WEEK 13 NAunmibmaelr `Successive 10-Minute Intervals 1 2 3 a H 6 Toul Group VII: 60 mg/kg/day 645223 124 1 130 144 144 159 a8 664455223473 113473 1244 110358 112380 19373 1616 650s8 645244 102 129 nr 133 27 0 ns 664455225696 114049 113584 114480 114669 116569 1o 58 m9% 664458227800 112545 117362 115298 113593 13416 1w 09 m89% 648300 137 102 162 7 16 6 sn 645305 136 7 149 36 2 2 es Group IX: 300 mg/kgiday --~ 644532310 7 m- nm - 109- 51- 102- 8. 66455224419 1113s2 110342 110574 1I62 13077 117s 467s 64261 135 102 161 158 27 st 7 664458227672 1i39 116338 113556 2124 1360 311 a8333 6is282 159 134 13 134 23 149 82 61828 17 123 128 123 128 132 751 648306 152 160 150 128 1 2 ell -_-- Company Sanitized. Does not contaln TSCA CBI 9H02.4D6a7y8:OrSaubGcahvraogneicStTuoxdiyciintyRats DuPont6554 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS NuAnmibmealr BASELINE Successive 10-Minute Intervals 1 2 3 4 5 Tow Group II: 0 mkglday 645346 158 161 57 146 155 86 763 64838 153 139 110 134 109 120 765 66448534004 11241 12297 21426 2512 110078 1306 6758 4a8s42s6 112369 21510 114372 116439 1944 1I64 780396 6aassaa237 114484 113384 1119 17510 81 &7 74930 645439 ns 51 133 119 18 7 73 oasaa 32 ne 22 149 is 2 S64 Group IV: 60 mg/kg/day Isopropanol ~ 64488336694 110461 11m68 1n38 7114 1276 112618 76838 645390 153 ns 200 12 us 1a 82 648396 127 mn 109 145 106 130 79 66448s3a9027 11404 113267 1239 18289 u10s4 1208 7s400 64488440098 1i3n6 11065 110285 110190 11351 12077 7mm 648410 129 106 127 126 121 5 08 6482s ns 126 33 126 27 144 4 Group VI: 10 mg/kg/day eas3s 137 2 105 143 133 152 752 61488336764 113675 114512 141 133 1g 148 3 100 143 129 00 81 cas 13s 138 11 12s 56 12s 70 64488440063 131s1 113397 61 145 110 145 20 153 1 re so 858 645414 159 144 146 143 11s 2 71 648429 116 124 9 119 109 128 04 64r8e433 112009 112236 130 i 13s 2 106 @ 130 8 759 476 -_ Company Sanitized. Dows not contain TSCACBI B 9102-4D6a7D y8O:raSluy GbcahvraognO eicSTtoxyu iciintyRG s nageSudyinpwDe uoPwones essssts INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS BASELINE NAummabelr Succesiv 10-Minute Interval Group VII: 60 mifkgd1ay 2 3 4 3 6 Toul eesssse ese w Laew Bosm Le 0s a1m8 as d2e 2 n1o6 10 osea aw CGsgs ssl 1u1s1 18 w seom1 ass a0 106 owwm or swuo 700 ssorl ew lp e w ns ds w1mm ms mmles s ms m m0 ww a ssw 0 Ww ms ws mes Group X: 300 mg/kg/day -- eesmss es L dn m@ ns 6 es Mos u0s eowms iwnm a 77ss om GsEsS ess e 19 owus08 m 09 m us msl em wm 00 4 eews 6 eessoes swe a mi1 m Bm m6 90% omis m3os nso as7 sowe 5 sw esa Me ms wom me qm --_ -_-- Company Sanitzsd. Doss not contain TSCAGBI H02-4D6a7y8:OraSlubGcahvraogneicSTuodxyiciintyRats --_ DuPont 6554. INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS Nu"Amnbimearl 1 Group I: 0mg/kglday WEEK 13 `Successive 10-Minute Intervals 2 3 4 5 6 Tom 6448833486. 11106 114176 114385 114489 14504 not 9850 664488340044 1141s4. 12236 1B3615 114206 112337 % 7 769 m2 6asa25 648426 136 129 161 134 138 1m 126 23 141 13s 132 6 84 706 648227 6i83 133 141 116348 113061 112530 115552 n123 7s6r5 618430 caga2 130 130 1 29 126 14 116 120 58 ns 23 ot 664 m Group IV: 60mykg/day Tsopropanol --_ 645364 648369 21 144 m 164 149 161 159 144 160 160 153 141 850 14 648390 648396 146 1s 112279 7 9%5 112044 BBlo s6e 661488349072 14%9 1933 19321 11028 1326 Ho 8 64 67 648408 648409 125 137 3124 1n6m1 114306 113027 261 8m343 648410 rn 150 8 164 st 165 mn 65 16 25 130 27 668 651 Group VI: 10 mg/kglday 664485334656 113359 113303 11521 114343 1585 139 BL 1 813 64684337842 1227s 113449 m162 118620 19512 [I 12 897 648403 648406 120 2 122 131 9 1s 104 119 25 7 is 3 515 0 east 64829 29 146 135 149 100 133 20 130 10 100 3 6 2 75 618433 4441 129 104 114052 12320 115085 11526 It156 m86s3 --_--mnm Company Sanitized. Does not contain TSCACBI 9F-02-4D6a7y8;OraSlulGbacvharogneicStTuoxdiyicintRyats --~ DuPont6554 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS WEEK 13 N"Aunmibmealr `Successive 10-Minute Intervals 1 2 3 4 5 6 Toul Group VII: 60 me/kgiday 6o4a88334s84 n19o2 1mns 115s7 61459 19s 1230 28077 pores 124 10 119 124 14 8 680 664488336880 115343 116059 1525 19553 710 207 8a1n2 648381 157 1s 1a 25 6 s62 oaassi40117 119309 112347 111580 112456 115471 m169 785989 i432 138 123 160 139 126 135 821 648440 m3 107 1s 107 1m 136 689 Group X: 300 my/kg/day 648350 B31 120 nm 1s ns 13 7 ~~ 648355 648359 2>7 ne. ns- 0. 8- 192 Ed- 648375 > - - . 5 664488337883 112146 1m35 12349 112149 115549 1123308 778m3 645387 133 140 128 1a 11s 56 689 664488339989 11410 117300 151210 12346 41067 11s0 66573 64sa19 - - - - . . . EE Company Santized. Doss not contain TSCA CBI 'H9-02-4D6a7y8O:raSlubGeahvraogneicStTuoxdiyciiRntyRaets -- DuDuPPoonmts6s55s4 APPENDIX K INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EEE -- `Company Sanitized. Doos not contaln TSCA CBI DH0:-2D4D6a7y8:OOraSluObGweahivrgaogeneSicuSTtdouxydiiycniiRtnyeRaetss ~ DuDuPPoonmte6s55s4 INDIVIDUALANIMAL CLINICAL PATHOLODAGTYA smoy seston EXPLANATORY NOTES 0H1m6" FerTInvieopsosmaoog/ekm7day VxV I WvIxn SGloooomrokaaslsdieeya TVIoesshotipcrlosepuabncssotlnatnrccooelntrol wWaiteerns users assmsvinnious: GenesCaWtW:EE asdaomqueaccelotted BNEMSRRTC| ndnoeotcrsetaaamkpselened rorecneoitvedporforormteedsting QROSUF C GCZuaoammnpitlceienycootnnotvdailstiucditOoiXnciofnotr efosrtitnegsting UD> C0 Lugrneaeabtleeerntochdaoncormine --~ aivciRcoCuCRamarstoaoamlmobeslyoncvdoanlcdueieltsli:ocnount. HBHCYECD rhhoeeammnosgtlocoeonrriipntuscular volum MMOOOUCU CaToaadanncocCloolrmppduuissscctuurllaerbrahtheiemomonoggwllioodbbtiihnn concentration AWBUEETT C Unpilbiasttoeellubeclteoscrdoeucscieeclalloccoyurnstcount MAAEEuRDn aiabmbsaaooolliuuutcteee nnleeyuumttprrhoooppchhyiitlle p(rael)curfsoormra) MAAOBOSSN ahbeeoolluuvtee msoemssienyapehhil beoluce basomnil AAMUBSCTC CT iiihbbaeeooollluuuttteee bTlaecsgto ulnesutkaociynteed cell miscellaneous Leukocyte SPEC spacial cbservations EnatvoRidmuSysl RednnBoilrsoeooacdlytcoersttsNorsholosy Valves: MWiCc C RUC - pahlaocclreyooeccnyytteoeemsssta 0 BMoiw hetyhpiemcsneryoemeasnia scanchomyeas TG | target cells ~~ SIT"CBCn| Hosopweecliolablsoedraovblesydecbvooardtyinootnsexamined; see whole blood sarple condition eesti Company Sanftized. Doss not contain TSCA CBI 9H0L-2D46a7y8O:rSaulbGcahvraogneiSctTuodryiicintyRats --_ DuPont6554 INDIVIDUALANIMAL CLINICAL PATHOLOGY DATA EXPLANNOATEST(COontRinuYed) AssmsvIATIONS: (continued) adiviodmua:l nitneorBmlsood Coll / Platelet Morphology Values: TO5$K56 btsomauiiiaecgebnuoenduiitteresophbillosod cells PSCVPEe -C gpvilaaacntutesliepatltaecdcellcouyctesepl/aessmcsmate SP"B=CCC Dsbopixezcaiorabrleseropvblesadetrevloafettisnoontsexanined; see whole blood sample condition aaivinucnaueyn C-oagbpulllaaasmteeiaonlhievpraeolmiuiyeaesi:s ATFTr C breotmihveaocmendinptaritvieal thromboplastin ime IodiviSSdUiuPmnl SerussmeerrauunmmdJhPeilmpaoestnmyaaeiCshemistry Values: --_ SASIT C ATC aafsloparanurimenaeitceavmeiarnneoitnrotasnasnfsetroarsaese BASIX0LP6 C aSsolotkraabllitiobnlielipdrhauonbsyipanhraotgaesnease GBEAC Gon Ccuhsroeelsaetsintnieitrnroeolgen qTuGme C gfCroliauglieyspereortiediens ioAesn CCCGaaolcbbiuim IHTSC sinooregmanic phosphorous FmLcIiPC PICT - pGCllhaalssommraaidhleeimpseimyiasisfrformobnloboldoodsusmuslforforlfuloruiodreidedecdeertmeirnmaitniaotnion plasms icterus from blood sample for fluoride determination BL plasma fluoride _-- Company Santized. Does not contain TSCA CBI 29H00A.2DD4aa67yy;OO:ruallSuGGbuachvvraoggneeiScStuTuoddxyiyiciintnRyatass DDuupwoontms5s54s INDIVIDUAL ANIMALCLINICAL PATHOLDOAGTYA EXPLANATORY NOTES (Continued) [En -- InatvQidna.nt Ortnqautaylsittsy v(amlousetst:ies color) rc TwsBDC mutrhieeneloesgahrpiietiistmyof the reciprocal of the hydrogen fon concentration WTWIoLroC1 rbhiiaonrseebilirubin w2 moo CeLrroiennieiipfrneoovsreeidnna 5550 mpecial observations IndiviBTdurcal OrineFepiinMtiehcerwrohisaicdtoepvipeeltoimserdamciontatcaion Values: WNEeRY 1 rnoirnmeanrecdryalvoaosse setts ' See 1 Tafa ovservaciens -- a _-- Company Saniized. Doss not contain TSCA CBI 9H02-4D6a7y8O:raSluGbcahvraogneicStTuodxyiciintyRass -- DuPont6554 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (Continued) SpeT3ciOal oekbrseaesrevations: 30a maderato DbeeirnSeheiMrgihcernpooeswceomrpsifceievladluas: por hsigehrepopweern Feld moderateitTE 1T1R50 moderaItea -it3E,6-sV0n/iEield any 5 any Ssoveiela por sloeumRpiuoopew)cerysfield P2ToI0oE6r por lowcdpaoomwser field omeaarnsy - 3i0id sorzs: Wothheenr<eodaisvoindsu,alaallnimoaflwhdiactha aarree neoxtplareipnoerdceidn, tLhte msaEyudbsordecuoardteorone of the following ressons of tthhVeearelsiamdmepslFeaiuvnlastsutcciolcuoiltetnetdnocrs1aobmmep)leobefaoirnatda.st(in)g (iS) ~~ C5thh0ee'saaamanptilpriaealwavGsiansdavnpaoritilaosbruliettaobolsreammefiosertictnoegtsltei(cnWtgRi)on hp3e6erdnforfamonredianondnyivhCiaadllufaclultoahtbeisorenerscvotpriedorenfdorvwamalesuder.veictohFrdoertdhsatxaassBpiblleeii,rnugbLiflnesbsGialtitehr:aunbina wcaosrcarienpovraeleude,aec2a0l.c1usla0i.o0n8svvaesre WTy1io0er8ne3apvenarsfSonsrdmieevddidoufnaolrthoaebnsyercreavcsaoctruidioeandtvwiaoalnsuser.peecrofrTodorremdeedaxasmwpbiletehi,ngthAgaftrsapstepecesicfiiftichcanGpreaavaivctieynrytwadaiasnterv:aelpuoer,iodcalaecurliat0i8o3n:s `Company Sanitized.Does not contain TSCA CBI ~ 23 Ey] mess gmmenss seaeanas 3 i z Hl gigafEgEgd dfdsidds dgddidddss 2 5 | IiGIEEIEID RINE sasanamin | I | SIEEEIEIT gEEnIESIAT Zasasasis I g g gx 2a2s2s9sETEaSTEdTsT dS7EgIdTeIESdSaIdS dSd2ssnnsedNdadTangs --_ I i ge FijgEEZEZZ Zk2asmnnen nasensenes i "| I337EEIEDT 2EQIEeINID ainiinm "| SUIIEEIEGY IRINIESNIT 3aadiaiis $1 Z S298EERESY z TESRRESEAY 3 29338358338 LE "le z g 23 2 | ! BEEEEEEEEY @ BESEEEEEEN 0 SNEEEEEEE ~4 ; , HEN | HANI I 3 v| mE em I | sm i HE - iPeo opoman oman F Tr WEEE rwEE nw) nEnnn smEEn | 2 gl : g1) zszzsazass ssssconsas 3 8 $ ssssssssss B sgsssnssss H |: : --~ z i i 87 2 2 8 3| emEmEemEeE memEEESSES EEEsEesess 3 5 8 7 EEEEEEESEE EEEEEESEEE BEEEEEEEEE i 8 ssssssasss sesssrsss: nzssouzens i 3F fg3|| SzaIsSzeTeIzeNsEs Rsea3ssdmtsisssizns I sssEemE siaEan -- FI { B3| 3a3neEsEns REEsuesIsy sasmsauas * ii i B| 3353468683 SEIRMETIGR 339338399 3 2g%f] 2232 5 2 z ~ 35 4$| S33u8383sE%sEsosff JEdSeInREsSaEsRsT ius3imaedssdsascess 3H)E; eeesereese :J spescesa ses oenessesses le3 [SoForRaInNoTeEsRIsReIsEs : sOeJaRgRnAeSRsIsEeEsE 2i + gAsRvEsRiEgaEsEsRs gl. B a ERE i PRL i ~3 3 3 8 | g ) i 3| EmmmemEEsE SEspsssees T fl i 7 EEEEESEEEE EEEEEEEEEE i 3| 333%3333vn sEynassgss i F5f mmm faq 7853838588 sE8N39gEsy sem --~ : oF) iiY3]| ausmaERen gEIgEagsss i | 35hRRERRLT Engaging 3 B235339RRS 3E22%03ERY 2 Topnerpneene peeseenser 3 {| 2 2 I : bt "| sasszanans 2 sesnsonna Bo 2s 25] 5 snezssesss samsazesas 3 4 33333333 ; FEEIigiiil i" : : ~ o1 g HEnRE mE mmm 8 3 3 rr i agRaeaas i 3 8 & | SHAEIAIRAE MIESEIEND Inman i 83 Mmm mmm mama i 3i: ) HjIEaIENEEIRr p GENEIn GEINY monimmmnen P3oo) | sS8mSmdRedmisiri iIRAmsduiacmes sAmsssamsaoduacss F : | SHEE nNmNG Bunn | SER nna mmomnnnim 2% 3 2 i i is 4] snsecsness gssanannec 3 smessanens "le r | Fossssssnges : syspssnuss | : ssssessnes aot oaessoasren bs i 5 SHEESEHEE sh | HEE i 2 ~~ 2IE) mmm semen 3| i ddsdsdsdss dsddsddss &2 |omnmmnm oman i 8 t| EI BEE I PY mn man iv mEnnE snmen r| cma smu | IIIA oaniInin: 4 ih : 83 i 33ansEeaes ; 33315naess 3 g S sssssssEs ssusssEsss -- id EH | ses i 33333323333 g g 38" | gi 3 EEEEEEEEEE EEEEEEEREE EEEEEEEEES 3 3 e g3 EEEEEEEEEE EEEEEEEREE EEEEEEEERS i 3 3| 3333333%3% sEsssensar nudngsnses i y faq I583IRIELL 8333883788 s3Enzeesss ~ FE 3 BF| GEREIEERET i aagEmEIR aammamems i | 3RIURJFERT FTIYNINGT 35R43IANAI 24 i3 228$ ~ 335 H GEN rBmmE nemasmaam 3|!: EEEEEEEEEE 2i EEEEEEEERE F: : EEEEEEEEES ly 2)| Fo HcoEsIsnNsEsese MssEaSsEaAssNsEsEs e ssgrn sssnss 18KH]1;i s8E8gE8gE8sR5ia0ss8ss3ge5ss9 |i cS5E5EI3iN8EE8sN3iE8gE3sA8sR3 |i fSREEginRNEggRsfssaassnaesn g g i ~3 ? 5 i E 4 EEEEEEEERE gEEEEEEEES i i El EEEEEEEREE SEEEEEEEEE 3i 42 2$832384N9E53E3En mgmunmaEnamgausms - i | 2729749 $343883898 i | WnINIE Bun 3 5 i23 3 ~~ 23) 2 z {| 2 "v3 X82l , EEEEEEEEEE EzzAszTscEasNss Ha 2 SEEEEEEEEE gE 8 u ssronssom gas 22 | 5 333IIITIEIF . 3BEFFIZISE 2 | wa - ]og oys) smmm ame ] 3| GgResEEgsE EREmagsE: i 4 didfdddsds ddRddadt i | ERAN AERdaaane | B| dEdRdidds ARdnanEE } i : "| REESE Inne iPoo) | ds3m3mianamdassra mAsdmsdam na : 7 iREdacilE 3daEst | SEIRIEAEEE ddEIaage 4 sssmnanee {anne go3l g | F esssnnnas 2 sesspussy ~4 i i : ` i3 | ir3y] en mm 4 EEEEEEEEEE EEEEEEEER i tT Eich iy] mann mmm i | em mm 4 | : yy ; wy n 8 la)! ounemn f: oams "| 33%F GEESE BER@y EERE 3 i . 2 3 444% degdd gdddd Ydddg 2 4 Tenommmommm me i " I3ED 0 GREE AEE EEE I | SEED MEER BEE EE i i 25 i gx nSy2e5g7s tSnesnsss asenasnsas EsSeeRs --~ 1 le i ge 333% 3aii3 sid3 daas ! " IEE EE SEE EEE J I}2% iH 8 ~ i=s B| iR3kE 0 ENE GEER MERE 8{| :I83E882R;I58E 830 oor Fores "le g 8 | 3 BECLLL i ; Ede | BEE g g E i 5880m 5 z m 3339 i bens 8 gg5ys 2 8883 hm Cand i i ~ 3 z: { i g| ] i EEEEE EEEEE EEEEE EEEEE } 2#23 i is ~ i 83 833483 55155 33838 52s ge 25383 3ss3 53333 ksuss i) ss om osm oem i] me om osm om h Fame Famer fovem Tenn ig : i i pr) Fumes aman onsen Foes il : g 5 cot} menses oazess 23| i; $3333 i; 33IEF i, IIFE 4 8% --_ 4 4 susssesman fdsgdaieed sg3zcEsssEnRdseanys "gaaagnEgzEgReanssg 8_ i ee 3 ddgdddssdd sesdsdddsd sdsdstdsd : i | diEiididdd ddan Anam 5 8 IEEE EENEEE BERREE i i 5ge | iionaiaddiadsdaases daessEniEddEasEs EsiEnaRnaEad - i ge 2G3i3d3E3i5i5d5e8d8 sAsNsNsNssEoIaRsEs AaNcNasEafrinas i | IidEENI ulin mloaenem 4 23 g --~ 284 | IEAREANEEE IEMEREMEE SEERA ihp23) F sssrannss i| szaseanses i| senscanas | 5 rere : EEEEEEEELY 5 BEEEEEEELY i i po pp eee 3: {{|| Ton mum g8 " ddsgddiddd fddnddadad k | Frie RE i it ETE EE I Pv] mama smn ~ fo : i3sa3anans Assasnsdns TF EEE Sub | Lim mas 3| p R38388333% | 537858378 i'l EE] xis 2% n EEBEEBEBEEE 3 ii Dinos :g 7 BEEEEEEEEY opninine ~i i i ~~ 2 ] | i 4 BEEEEERERE EEEEEEEEEE EEEEEEEEEE i 4 BEEEEEEEEE EEEEEEEREE EEEEEEEEEE l | EERIE mEEDEED anEeE I y8 gay 2338982532 8385858nE nS353ENINY Ew - - i HH 8525933537 8390388538 $5325EaSas B | 3833888330 AES%IAERNG GERInERATY PH3 i i i 23g ~ 25 =8 4 FRIINNY sma mamaemm NE i 2 2 SEEEEREEEEE | HEEEEEEEEE | EEEEEEEEEE tle" 2 2 ily B B El ; JE3TRRITEY ; vEnANNAnNY . 3nanienges * 3ish]f i|. sssaezsEsisrBsaBssuEsEEncasEis g|f IBgaRsgEgmRgeEssEsmEsaEesEsrDy i| mBsgaRrmEasRspEsaaRsgEanEss 18 i m 2 g3 8 | 3 z3 33 4 EEEEEEEEEE EEEEEEEEEE i 4 5 EEEEEEEREE EEEEEEEEEE 33 SI3IIEREET IEEE ! 3 El 3333388 aIamEnaE --_ ;fFE sBt 3n3onmmInEtEaEmn as3nsadmsbanineEs i3 %: Y5sl 3su3zIsEnRoEnRsEaEs EAEAANENINEAMnEeMnRd 4 . EINE nn iF 3 2 e EEEEEEEEEE | EEEEEEEERE 3 {| BF i2F%! %41 ]g5 sacugzesss srsssasuas ii g| 3933325300 aman _&8 28 fs GseiRaEnEaE s anmnna ~~ 3 ] & | IEmaaANiN pIEnImMAEM WERMm : 4 ; : i & IAIN AEREAREEY RARE 3i 3 B| SREdAsRass AsRaRasd AarassaRss i i i "| FEXEEEEEEPINE EEE EEPEEE EREFREE : "| ii3iiddadu Gavsdsdncs adoscsAcs : "| i33dddaad REEEE dau #| 33339333R3 IEGMENEER MEEESEE: . g)4 F, aSmnsoensu nee | sm smarm nvenm s sm egsenE sans 2% hE : : 3 8 | : BEEESEEEEE | SEEESEEEEE L s58555885% 3 z 3 --~ 35 i i i ~ BD) amaaRNEER amaaasaaas | am man B| ARdRdidsdd AZRAREARE 3 3ferg) | gaeisEssaiasnss:s Issmsasasssnas _ g ;foi) Jcnaviadnsadadainae e3vEmRessEqEvdeasRed 23 i22 239 --~ 3&g3 | BEEEE BEnEEn | e EsasREiERE , SInEEEEEE 3 LO BEEEEEEEES sxsyssyysy B : ; =u | ezassmanas coessssasne i i; lfaEeasy | BaREESRiat 2 i IITITISIIT i I3IIITIIIIT ~3 2Z2 . | fl3 EEEEEEEREE EEEEEEEEEE EEEEEEEEEE 4 EEEEEEENEE EEEEEEEEEE EEEEEEEEEE i5 2 og 4228585853 4831258488 %255538nuE 5938353%% S9343%%4an ssnd3assas ~~ 3% i 3| 393339338 UIIIINIT 5333TeAER Fae "i 3 # spanuanate $333333d33 925%a88aa SASassdun | SSARNAAASA 333333d3qs 335d: sasysamsas asgnsesaga 2 z EEEEEEEEEE i EEEEEEEEEER i EEREEEEEEL id 3 i|ls:T vm: mn : nv Zz 2 2 be 13 | ; 585385333% . oEggzzssl , ZETIEEsSs: 28 j ii : J . ~3 3g 5 5 g| i gs EEEEEEEREEE EEEEEEEEEE 3 : i g EEEEEEEERE EEEESESEEE 3 {| g : # & 4 fbi bi I 3 3 4 33933398 Emam ii %3 IERIE 33E%EERE : iae) 3cr3u3s3n3a3s3e3s8s I59M9MES%EEIMER go SETi o il 52 2 3 4 Hoh EEEIIEAR EEEEEERERE AAaaseRans IanEaEaeds g : EEEESEEELE oananaeaan i --~ 4 fl gor 8 ge ~3 FE S99IRERET dRERnaALY Bs g4E%GaeReE JEgRSgEAR i : 3 gs f99d8d98s ddcdddses 2 4 Tem me vl GEER SHEE i BB0)-| J Fidiaaats Rts AAydAaddlndaan | ii sesesegegn semanases PY ddsgddsts dddddddds --~ 3 I ge didansiol 33iiddda: fr EEE HE | EE f4 ildlo)!: i) Fans: | sms 3 | 0 sssmstsosgssussgessy ~~ hi ~3 . { |zi iag Ee 3 EEREREEEEE EEEEEEEEE i --_ i = gi $398336883 088355588 | samme sme Hi 52 azzaszene : 333358388 . il : 3 | | ames assem #8 ~ 3g gi 26953 ESERY 33RE3 R3eH 3 BEER sgRRR BERR BREE i {g| - oT 3 3 v-| emo egies ele Engases EEaaa ii i pos omen ann i i 8S g8 x =2"EsIsYgT E2E7T8?8 2ds%aE"Ts 2s2E2n2d2s ~ g la Ige 35303 EiR33 333% 33a i : " EEE EPRI GER EE gE E | Bas aE an i i3 : gp| ges | eeene gp nmeer | nem i g | EEEEE : E353 iFETE : BE% id : 3 : : ~ i Bly pepe pee i ~ i ii 8| i 4 EEEEE EEEEE EEEEE EEEEE 2 FHI i spy men gsm se i _ os ge 3583 ENESI 388E% 33333 y sean men osm am Bl 632] EREIR smgEn gmans IRE TT] 35388 anang 3 k| poem meng one ena ~i joes gene fe game i "og 0 5 i tn on 8 | i5f 3 MASSON Spas inann ddasansnns i a ! P, g een nme seen :5 it | DRUOLIIID biriiiinin iii i ~ 3Tg | ceeiieien meri seeeaeeeen L id TH) enn nnn non i BRUIDIIIID iiiiiviie Gini i | 3 | ~ ief EE me i Fone E i opine i oon : ii SESNEENNEE iJ danas j|oe Gosbocnen --_ | : 2 phir prbbrb 8 3bl REESEEERE FERN) 2 ii | anaiasans onjmanannns iBE Pg| mms mnemen 3 5 i iE trirrina Prrririing 8 - ii 3 hist Cid i iv Brinnon nnn i 5 % 3 i ~ Hs Cy BF orrriiinin Boamrrrrinng ar 5 FRE ~ gg 2 8 3 3 2 i : i Pp i: L 1 3 i i i :3 i: :z +2 5 : gl 2 gt H :BE 2 : i ; i ; ~ #4 0g IRIE g sesame ~~ 2 8 i 8 3 i 3 : ;] t i ~ i 3 3 i ; ; 3 [a  phrninen [REREREEER] | 3 | phim paprannany i viannenn) mmasecsnan i HE LEERERLE EEEL ERLEI ERE FERRE] !He It :i BLERIRROEE STRTTIPTIEEND LpnRinsRieead ERiIEED aetna HiELERRee gp 3 ES goi Torii BE $n i = fon i 3 at i 2 osaanaaaae | sEgessgsan i 3 EEEEERERE 3 i TOY3 | in sn i!8 : E Wbe rbinann tertieeies ii || hanna pri ii | j iJ ) Brrrrnninn prnnneies 1 i : trriPnrtrirninno rnin ; | SE tr ttrrrrin 3i &s: ~ 25 =8| B:p : sb1i 523 | jzsmamenes i ~3 : | ~1 i 2 ' : gol 5 : 30 pf ~ 8 i; |: i 3 1 z i : : : i i : : : ; HEE Ba : al 3 ii i i 5 i : i i 8 H $ ~ ; ; i K g # 2 5 HHI BERNE - : | nn sn | PRLiiRi hii i P| ae pee : . 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