Document 71zem19jG5GM1Kw9J0bXa2y38

Copy to H r. Graham Edgar A p r i l X&, 1 9 3 k Sr R. U Harwood MoO11.1 Univr s l ty M ontreal Canada ' . ' Dear Mr# Harwoods . ' 1 am n a t u r a l l y q u i t e sy m p a th e tic w it h you r in te r e s t in the production of cen tr a l nervous system l e s i o n s by th e a d m in is t r a t io n o f le a d com pounds, lie fcnve been m aking some o b s e r v a tio n s o f t h is typ e on e x p e rim en ta l a n im a ls b u t wo do n o t h a w any v e r y d e f i n i t e o r s p e c i f i c fin d in g s to report I th in k , however, I should acquaint you w ith ay sk e p tic ism con cern in g the e s s e n t ia l s im ila r ity o f l e s i o n s w h ich may b p rod u ced b y t e t r a e t h y l le a d ad compared w ith th o se which a fg h t bo produced by in o rg a n ic lo a d com'.'pnnde Our c h e m ic a l o b s e r v a t io n s i n d i c a t e th a t the d is t r ib u t io n o f le a d in the b ra in t is s u e s i s somewhat d if f e r e n t in the two in s ta n c e s# With t h is background o f in form ation , X should regard i t a s dou btfu l whether -lesion s produced by t e t r a e t h y l le a d c o u ld b r eg a r d e d a s c h a r a c t e r ! a t i c o f le a d Compounds in general However, that- i s a mere d e t a i l and th e p r o d u c tio n ,o f s p e c i f i c ' le a *ons In any in s ta n c e would be a m atter o f c o n sid e r a b le importune# , U n fortu nately 1 aa not in p o sitio n to supply you w ith t e t r a e t h y l lo a d 1 have: o n ly a v ery sm all amount o f th e p u re t e t r a e t h y l le a d w h ich was s u p p lie d t o me b y fchs R esearch L aboratory o f th e E thyl G asolin e C orporation# M oreover,. I f 'I. did: have., t h e m a t e r ia l on hand, I w ould h ave some c o n sid e r a b le , r ese r v a tio n : about su p p ly in g i t to you w ithout f i r s t ob tain in g the consent o f the o f f ic ia ls of th e E th y l G a s o lin e C o r p o r a tio n , s i n c e th e y hav a d o p ted the p o lic y that the relea se of tetra eth y l lead to in v e sti g a t o r s smsfc b e i n e v e r y in s t a n c e c a r r ie d o u t by th e d e s ig n a te d r e p r e s e n t a t i v e o f th e C orporation A c c o r d in g ly I am r e f e r r i n g you r l a t t e r to Dr# Graham E d gar, D ir e c t o r o f R esea rch o f th e C orporation w ith th e recommendation th a t the m a te r ia l you request be su p p lied , i f i t is possible On th e a ssu m p tio n t h a t you w i l l p r o b a b ly r e c e i v e some sm a ll su p p ly o f te tr a e th y l le a d , I w ish to p o in t out th e quit co n sid era b le danger o f han dling even s s a la m o u n ts o f t e t r a e t h y l lea d * The compound o b v io u s ly can b e h an d led w ith s a f e t y by. exp erim en tal workers bu t I t w i l l not brook any c a r e le s s handling I t la cosaary th at p recau tion s be taken a g a in s t s k in c o n ta c t and a g a in s t any In h a la tio n # Thus a l l ' VtSfm Urn Kar oo od work w ith anim als should be e a r r ie d out in a hood w ith str o n g fo r c e d v e n t i la t i o n , I have no doubt you understand ;tl^: e o f S B iir f .b a t a s a n '.add |i|fcio8K3* |?reQ.te.fei o p a f i$e^a;iiie!> to ;|:|i0 juafeli&h % tjao v r r s i ^ ^ ' h g |a c l: t d ; give': yota an y :f h i t h e r i i s f o r f e a t i oil s f ilc h I have which m ight he o f a s s is ta n c e to you C ord ially yours , RAKl XS