Document 71XqN7V4qYQegaGQpxZJDBvaB

grtorf - iw if AMM- 3t* H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_________________________________________________________ DuPont-6554 TRADE SECRET Study Title H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Volume 4 of 4 Laboratory Project ID: DuPont-6554 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) Author: Don A. Delker, Ph.D Study Completed on: April 22,2002 Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Work Request Number:j f l H I ) Service Code Number: W H 1 | Clinical Pathology Study Number: Page 763 of 1022 Company Sanitized. Does'sol oontain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 APPENDIX L INDIVIDUAL ANIMAL BIOCHEMICAL MEASUREMENTS IN MALE AND FEMALE RATS 764 Company Sanitized. Does not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Individual Animal Data In Male Rats At The 10-Day Time Point Group I III V VII IX Animal Number 648327 648328 648336 648338 648340 648316 648319 648320 648325 648335 648317 648318 648331 648333 648337 648322 648323 648329 648334 648339 648291 648321 648324 648326 648332 Beta-Oxidation Rate (nmol/min/mg protein) 6.7 9.6 6.0 9.5 6.6 5.1 8.2 7.0 6.3 13.4 8.2 6.8 8.1 7.5 5.7 4.3 6.2 5.6 4.3 6.0 14.1 10.2 9.6 20.6 14.9 DuPont-6554 765 Company Sanitized. Does not contain TSCA CSI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Individual Animal Data In Male Rats At The 90-Day Time Point Group I III V VII IX Animal Number 648225 648247 648307 648315 648256 648302 648274 648227 648299 648303 648288 648286 648309 648221 648312 648300 648305 648280 648259 648223 648236 648217 648248 648218 648239 Beta-Oxidation Rate (nmol/min/mg protein) 9.2 10.3 10.0 9.4 9.3 7.3 7.6 7.8 10.7 8.4 10.7 10.1 10.0 12.0 7.0 13.7 16.0 12.4 12.2 14.5 21.7 17.7 19.7 24.3 15.7 DuPont-6554 766 Company Sanitized. Does not contain TSCA CBl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Individual Animal Data In Male Rats At The 1-Month Recovery Time Point Group I IX Animal Number 648222 648250 648260 648264 648271 Beta-Oxidation Rate (nmol/min/mg protein) 14.5 13.0 12.2 11.3 16.3 648241 648261 648277 648284 648306 25.2 20.3 22.5 23.5 21.7 DuPont-6554 767 Company Sanitized. Boss not contain TSCA CEft H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Individual Animal Data In Male Rats At The 3-Month Recovery Time Point Group I V VII IX Animal Number 648298 648228 648297 648219 648226 Beta-Oxidation Rate (nmol/min/mg protein) 12.5 15.8 14.9 9.9 19.2 648283 648254 648310 648265 648253 13.2 15.9 13.5 15.3 20.1 648279 648296 648314 648285 648268 23.1 20.2 12.6 16.6 17.3 648292 648272 648234 648240 648287 21.6 27.0 16.1 23.2 23.1 DuPont-6554 768 Company Sanitized. Does not contain TSCA CBt H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Individual Animal Data In Female Rats At The 10-Day Time Point Group II IV VI VIII X Animal Number 648463 648456 648459 648451 648466 648446 648468 648454 648445 648461 648460 648447 648452 648449 648443 648444 648467 648469 648455 648450 648464 648457 648448 648458 648471 Beta-Oxidation Rate (nmol/min/mg protein) 11.0 15.6 10.7 13.7 13.7 10.6 5.4 7.6 10.5 9.1 14.1 13.6 15.8 13.0 15.0 19.7 15.1 19.6 14.8 13.8 21.6 16.7 19.5 23.1 18.4 DuPont-6554 769 Company Sanitized, Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Individual Animal Data In Female Rats At The 90-Day Time Point Group II IV VI VIII X Animal Number 648421 648393 648436 648430 648351 648396 648409 648410 648369 648397 648433 648406 648441 648414 648366 648380 648381 648432 648440 648348 648376 648435 648392 648407 $48347 Beta-Oxidation Rate (nmol/min/mg protein) 17.9 15.9 16.0 21.7 19.8 19.5 14.2 14.6 19.5 19.4 18.6 16.5 18.9 17.0 18.0 16.0 17.7 20.9 18.2 15.8 27.2 25.0 25.6 19.4 21.8 DuPont-6554 770 Company Sanitized. Does not contain TSCA CBl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Individual Animal Data In Female Rats At The 1-Month Recovery Time Point Group II X Animal Number 648389 648425 648434 648394 648426 Beta-Oxidation Rate (nmol/min/mg protein) 20.2 17.7 14.2 18.5 18.2 648355 648378 648387 648419 648350 20.1 22.8 21.9 19.7 24.6 DuPont-6554 771 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Individual Animal Data In Female Rats At The 3-Month Recovery Time Point Group II VI VIII X Animal Number 648356 648431 648422 648357 648405 Beta-Oxidation Rate (nmol/min/mg protein) 15.3 22.3 18.5 14.8 19.6 648384 648365 648413 648385 18.6 15.2 17.9 15.6 648349 648415 648379 648386 648360 26.7 25.7 21.5 19.7 24.5 648373 648358 648367 648391 648411 24.7 18.4 28.0 23.7 25.1 DuPont-6554 772 Company Sanitized. Does not contain TSCA CI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 APPENDIX M INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS 773 Company Sanitized. Does ml. contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Organ Weight Listing (90-Day Exposure) Group : I - 0 mg/kg/day Treatment : 0 mg/kg/day I Sex :MALES ANIMAL 1 FBW 1 BRAIN 1 ADRENAL GLANDS | EPIDIDYMIDES 1 (Gms} 1(Gms) %FBW (Gms) %FBW %BRAIN j (Gms) %FBW %BRAIN | (Gms) HEART KIDNEYS 1 %FBW %BRAIN (Gms) %FBW %BRAIN 648220 1618.30 1 2.083 0.3369 1 0.057 0.0092 2.7364 1.460 0.2361 70.091 1 1.694 0.2740 81.325 1 3.744 0.6055 179.74 j 648225 1530.00 i 1.984 0.3743 1 0.047 0.0089 2.3690 1.520 0.2868 76.613 j 1.648 0.3109 83.065 j 3.402 0.6419 171.47 1 648238 1570.80 1 2.112 0.3700 0.067 0.0117 3.1723 1.438 0.2519 68.087 1 1.593 0.2791 75.426 4.032 0.7064 190.91 648246 1558.50 1 2.154 0.3857 j 0.057 0.0102 2.6462 1.637 0.2931 75.998 j 1.716 0.3073 79.666 3.823 0.6845 177.48 648247 534.70 1 2.112 0.3950 0.066 0.0123 3.1250 1.333 0.2493 63.116 1.535 0.2871 72.680 4.063 0.7599 192.38 648255 584.30 1 2.123 0.3633 1 0.059 0.0101 2.7791 1.333 0.2281 62.789 1.732 0.2964 81.583 3.932 0.6729 185.21 648256 551.50 1 2.183 0.3958 0.058 0.0105 2.6569 1.221 0.2214 55.932 1.569 0.2845 71.874 j 4.076 0.7391 186-72 648307 529.00 1 2.041 0.3858 0.057 0.0108 2.7927 1.530 0.2892 74.963 1.721 0-3253 84.321 3.814 0.7210 186.87 648315 538.50 1 2.147 0.3987 1 0.066 0.0123 3.0741 1 1.483 0.2754 69.073 j 1.578 0.2930 73.498 1 3.405 0.6323 158.59 1I 1 1 I1 Mean 557.29 1 2.104 0.3784 0.059 0.0107 2.8169 1 1.439 0.2590 68.518 j 1.643 0.2953 78.160 1 3.810 0.6848 181.04 j S.D. 29.744 1 0.061 0.0198 0.006 0.0012 0.2625 0.126 0.0277 6.9499 1 0.076 0.0166 4.8059 0.258 0.0517 10.719 Group : III - 60 mg/kg/day (Iso) Treatment : 60 mg/kg/day III Sex MALES ANIMAL 1 FBW 1 BRAIN 1 ADRENAL GLANDS | EPIDIDYMIDES | 1 (Gms) j(Gms) %FBW j (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN | (Gms) HEART KIDNEYS 1 %FBW %BRAIN (Gms) %FBW %BRAIN 1 648227 648232 648252 648258 648269 648274 648290 648299 648302 1580.30 1616.00 466.40 582.70 531.50 581.10 593.80 569.10 561.10 j 1.978 2.183 2.066 2.107 2.219 2.198 2.133 2.273 2.156 0.3409 0.3544 0.4430 0.3616 0.4175 0.3782 0.3592 0.3994 0.3842 1 1 1 0.043 0.053 0.053 0.063 0.061 0.047 0.060 0.056 0.051 0.0074 0.0086 0.0114 0.0108 0.0115 0.0081 0.0101 0.0098 0.0091 2.1739 2.4279 2.5653 2.9900 2.7490 2.1383 2.8129 2.4637 2.3655 1 1 j 1 1.523 1.434 1.329 1.532 1.545 1.432 1.572 1.524 1.663 0.2625 0.2328 0.2849 0.2629 0.2907 0.2464 0.2647 0.2678 0.2964 76.997 65.689 64.327 72.710 69.626 65.150 73.699 67.048 77.134 1 j 1.638 0.2823 1.874 0.3042 1.566 0.3358 2.255 0.3870 1.697 0.3193 1.741 0.2996 1.700 0.2863 1.725 0.3031 2.076 0.3700 82.811 85.845 75.799 107.02 76.476 79.208 79.700 75.891 96.289 1 1 j 3.975 4.429 3.292 4.015 3.896 4.301 3.754 4.095 4.016 0.6850 200.96 0.7190 202.89 0.7058 159.34 0.6890 190.56 0.7330 175.57 0.7401 195.68 0.6322 176.00 0.7196 180.16 0.7157 186.27 1 1 1 1 1 1 1 1 1 FBW - Final Body Weight 774 Company Sanitized. Does not contain TSCA CBt ) H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats )) _____________________________________________________________________________ DuPont-6554 Organ Weight Listing Group : III - 60 mg/kg/day (Iso) Treatment : 60 mg/kg/day III Sex MALES | ANIMAL I FBW | BRAIN | ADRENAL GLANDS | EPIDIDYMIDES | ! 1 (Gms) 1(Gms) %FBW 1 (Gms) %FBW %BRAIN 1 (Gms) %FBW %BRAIN 1 (Gms) HEART | KIDNEYS %FBW %BRAIN 1 (Gms) %FBW %BRAIN 1 1 648303 [538.20 1 2.225 0.4134 1 0.055 0.0102 2.4719 1 1.504 0.2794 67.596 1 1.787 0.3320 80.315 j 3.931 0.7304 176.67 1 I1 1 11 1 1 i 1 1 1 Mean 1562.02 1 2.154 0.3852 1 0.054 0.0097 2.5158 I 1.506 0.2689 69.998 1 1.806 0.3220 83.936 j 3.970 0.7070 184.41 j 1 S.D. 41.823 1 0-087 0.0326 i 0.006 0.0014 0.2717 i 0.091 0.0197 4.8281 j 0.211 0.0347 10.169 j 0.308 0.0318 13.493 j Group : V - 10 mg/kg/day Treatment 10 mg/kg/day V Sex MALES ANIMAL i FBW BRAIN 1 ADRENAL GLANDS | EPIDIDYMIDES | j (Gms) (Gms) %FBW j (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN j (Gms) HEART 1 KIDNEYS 1 %FBW %BRAIN 1 (Gms) %FBW %BRAIN 1 648221 648224 648245 648273 648286 648288 648301 648309 648312 648313 i627.20 540.50 558.40 547.80 622.50 477.00 553.50 561.60 599.20 j648.50 Mean S.D. 1573.62 \ 50.992 2.163 0.3449 1 0.055 0.0088 2.5428 1 1.744 0.2781 80.629 1 1.727 0.2754 79.843 1 4.257 0.6787 196.81 1 2.096 0.3878 j 0.064 0.0118 3.0534 1 1.434 0.2653 68.416 i 1.592 0.2945 75.954 3.983 0.7369 190.03 1 2.186 0.3915 j 0.055 0.0098 2.5160 j 1.300 0.2328 59.469 j 1.747 0.3129 79.918 j 4.071 0.7290 186.23 1 2.147 0.3919 j 0.047 0.0086 2.1891 j 1.302 0.2377 60.643 i 1.679 0.3065 78.202 j 3.720 0.6791 173.27 1 2.196 0.3528 1 0.038 0.0061 1.7304 j 1.458 0.2342 66.393 i 1.661 0.2668 75.638 j 3.377 0.5425 153.78 1 2.082 0.4365 j 0.067 0.0140 3.2181 j 1.658 0.3476 79.635 j 1.562 0.3275 75.024 j 3.498 0.7333 168.01 1 2.152 0.3888 1 0.061 0.0110 2.8346 j 1.584 0.2862 73.606 j 1.783 0.3221 82.853 1 4.505 0.8139 209.34 1 2.168 0.3860 j 0.051 0.0091 2.3524 j 1.522 0.2710 70.203 1 1.811 0.3225 83.533 1 3.769 0.6711 173.85 1 2.103 0.3510 1 0.056 0.0093 2.6629 \ 1.482 0.2473 70.471 j 2.736 0.4566 130.10 j 4.665 0.7785 221.83 1 2.239 0.3453 0.057 0.0088 2.5458 j 1.586 0.2446 70.835 j 1.948 0.3004 87.003 i 4.336 0.6686 193.66 1 11 1 2.153 0.3776 1 0.055 0.0097 2.5645 1 1.507 0.2645 70.030 1 1.825 0.3185 84.807 j 4.018 0.7032 186.68 1 0.049 0.0291 0.008 0.0022 0.4260 j 0.143 0.0349 6.9420 j 0.339 0.0525 16.371 j 0.428 0.0744 20.240 1 FBW - Final Body Weight 775 Company Sanitized. Does not contain TSCA C0! )) ) H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats____________________________________________________________________________________________DuPont-6554 Organ Weight Listing (90-Day Exposure) Group : VII - 60 mg/kg/day Treatment : 60 mg/kg/day VII Sex :MALES ANIMAL 1 FBW 1 BRAIN [ ADRENAL GLANDS j EPIDIDYMIDES | 1 {Gms) 1(Gms) %FBW 1 (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN | (Gms) HEART KIDNEYS 1 %FBW %BRAIN j (Gms) %FBW %BRAIN \ 648223 1636.50 1 2.087 0.3279 1 0.056 0.0088 2.6833 1 1.641 0.2578 78.630 1 1.742 0.2737 83.469 I 4.494 0.7060 215.33 1 648237 629.00 1 2.134 0.3393 i 0.057 0.0091 2.6710 1.578 0.2509 73.946 1.834 0.2916 85.942 j 4.113 0.6539 192.74 648243 547.10 1 2.130 0.3893 j 0.061 0.0111 2.8638 1.801 0.3292 84.554 j 2.014 0.3681 94.554 1 4.519 0.8260 212.16 648244 511.50 1 2.219 0.4338 \ 0.049 0.0096 2.2082 1.458 0.2850 65.705 j 1.802 0.3523 81.208 1 4.630 0.9052 208.65 648259 1551.60 1 2.150 0.3898 i 0.051 0.0092 2.3721 1.429 0.2591 66.465 i 1.840 0.3336 85.581 j 4.568 0.8281 212.47 648266 j614.20 1 2.078 0.3383 \ 0.047 0.0077 2.2618 1.697 0.2763 81.665 j 1.829 0.2978 88.017 j 4.207 0.6850 202.45 648270 1505.40 1 2.118 0.4191 j 0.036 0.0071 1.6997 1.588 0.3142 74.976 j 1.665 0.3294 78.612 j 4.197 0.8304 198.16 648280 1534.90 1 2.240 0.4188 \ 0.045 0.0084 2.0089 1.573 0.2941 70.223 i 1.532 0.2864 68.393 j 3.708 0.6932 165.54 648300 429.50 1 1.942 0.4522 \ 0.041 0.0095 2.1112 1.586 0.3693 81.668 1 1.488 0.3464 76.622 j 3.835 0.8929 197.48 648305 1575.50 1 2.263 0.3932 \ 0.057 0.0099 2.5188 : 1.368 0.2377 60.451 j 1.903 0.3307 84.092 i 4.488 0.7798 198.32 1 1I Mean 1553.52 1 2.136 0.3902 1 0.050 0.0090 2.3399 1 1.572 0.2874 73.828 1 1.765 0.3210 82.649 j 4.276 0.7801 200.33 1 S.D. 63.772 1 0.093 0.0429 1 0.008 0.0011 0.3544 0.128 0.0406 7.9893 j 0.163 0.0316 7.0764 \ 0.319 0.0903 14.419 j Group : IX - 300 mg/kg/day Treatment : 300 mg/kg/day IX Sex :MALES ANIMAL i FBW j BRAIN 1 ADRENAL GLANDS | EPIDIDYMIDES | HEART 1 KIDNEYS 1 (Gms) !(Gms) %FBW 1 (Gms) %FBW %BRAIN j (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN 1 (Gms) %FBW %BRAIN 648217 648218 648235 648236 648239 648248 648275 648289 648293 1538.30 544.90 529.30 495.10 628.60 465.50 441.50 613.60 454.40 2.209 0.4104 1 0.049 0.0091 2.2182 1 1.458 0.2709 66.003 1 2.185 0.4059 98.914 1 5.316 0.9876 240.65 2.026 0.3718 0.075 0.0138 3.7019 j 1.578 0.2896 77.887 \ 1.896 0.3480 93.583 j 4.630 0.8497 228.53 2.181 0.4121 0.051 0.0096 2.3384 j 1.606 0.3034 73.636 i 1.887 0.3565 86.520 1 4.820 0.9106 221.00 3.023 0.6106 0.058 0.0117 1.9186 j 1.302 0.2630 43.070 i 1.618 0.3268 53.523 i 4.488 0.9065 148.46 2.149 0.3419 0.048 0.0076 2.2336 j 1.418 0.2256 65.984 1 1.931 0.3072 89.856 j 5.241 0.8338 243.88 2.221 0.4771 j 0.054 0.0116 2.4313 j 1.371 0.2945 61.729 1 1.565 0.3362 70.464 j 4.294 0.9224 193.34 1.990 0.4507 0.038 0.0086 1.9095 1 1.217 0.2757 61.156 j 1.376 0.3117 69.146 j 4.035 0.9139 202.76 2.341 0.3815 0.049 0.0080 2.0931 i 1.379 0.2247 58.906 \ 1.731 0.2821 73.943 j 4.109 0.6697 175.52 2.164 0.4762 0.044 0.0097 2.0333 1 1.312 0.2887 60.628 j 1.626 0.3578 75.139 i 4.128 0.9085 190.76 FBW - Final Body Weight 776 Company Sanitized. Does not contain TSCA CBl ) H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats ) ______________________________________________________________________ DuPont-6554 Organ Weight Listing (90-Day Exposure) Group : IX - 300 mg/kg/day Treatment : 300 mg/kg/day IX Sex :MALES 1 ANIMAL 1 FBW I BRAIN I ADRENAL GLANDS I EPIDIDYMIDES | 1 1 (Gms) 1(Gms) %FBW 1 (Gms) %FBW %BRAIN 1 (Gms) %FBW %BRAIN 1 (Gms) HEART 1 KIDNEYS 1 %FBW %BRAIN 1 (Gms) %FBW %BRAIN 1 1 648308 1551.80 1 2.219 0.4021 \ 0.063 0.0114 2.8391 1 1.517 0.2749 68.364 I 1.995 0.3615 89.905 1 5.080 0.9206 228.93 1 1 11 1 1 I 1 I1 ] Mean 1526.30 1 2.252 0.4334 1 0.053 0.0101 2.3717 1 1.416 0.2711 63.736 1 1.781 0.3394 80.099 1 4.614 0.8823 207.38 1 1 S.D. 63.479 i 0.289 0.0762 [ 0.010 0.0019 0.5422 1 0.125 0.0270 9.4319 1 0.240 0.0348 13.944 1 0.482 0.0855 30.764 j FBW - Final Body Weight 777 Company Sanitized. Does not contain TSC CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Organ Weight Listing (90-Day Exposure) DuPont-6554 Group : I - 0 mg/kg/day Treatment : 0 mg/kg/day I Sex :MALES ANIMAL (Gms) LIVER %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN TESTES (Gms) %FBW %BRAIN THYMUS (Gms) %FBW %BRAIN THYROID GLAND (Gms) %FBW %BRAIN 648220 1 15.741 2.5459 755.69 1 0.776 0.1255 37.254 1 3.118 0.5043 149.69 1 0.328 0.0530 15.747 1 0.021 0.0034 1.0082 648225 1 15.852 2.9909 798.99 1 0.799 0.1508 40.272 1 3.494 0.6592 176.11 1 0.241 0.0455 12.147 1 0.025 0.0047 1.2601 648238 1 14.969 2.6225 708.76 1 0.915 0.1603 43.324 I 3.343 0.5857 158.29 1 0.273 0.0478 12.926 1 0.028 0.0049 1.3258 648246 1 15.049 2.6945 698.65 1 0.936 0.1676 43.454 1 4.128 0.7391 191.64 1 0.286 0.0512 13.278 1 0.022 0.0039 1.0214 648247 1 16.412 3.0694 777.08 1 0.824 0.1541 39.015 ! 3.138 0.5869 148.58 1 0.520 0.0973 24.621 1 0.030 0.0056 1.4205 648255 1 15.339 2.6252 722.52 1 0.826 0.1414 38.907 1 3.337 0.5711 157.18 1 0.501 0.0857 23.599 1 0.020 0.0034 0.9421 648256 1 14.096 2.5559 645.72 1 0.822 0.1490 37.655 ! 3.080 0.5585 141.09 1 0.431 0.0782 19.743 1 0.020 0.0036 0.9162 648307 1 14.150 2.6749 693.29 1 0.826 0.1561 40.470 1 3.964 0.7493 194.22 1 0.466 0.0881 22.832 1 0.021 0.0040 1.0289 648315 1 14.129 2.6238 658.08 1 0.847 0.1573 39.450 1 3.156 0.5861 147.00 1 0.317 0.0589 14.765 1 0.031 0.0058 1.4439 11 !! Mean 15.082 2.7114 717.64 1 0.841 0.1513 39.978 I 3.418 0.6156 162.64 1 0.374 0.0673 17.740 1 0.024 0.0044 1.1519 S.D. 1 0.839 0.1879 51.691 1 0.052 0.0122 2.2016 1 0.383 0.0831 19.821 i 0.106 0.0199 4.9851 i 0.004 0.0009 0.2097 Group : III - 60 mg/kg/day (Iso) Treatment : 60 mg/kg/day III Sex :MALES ANIMAL 1 I(Gms) LIVER 1 SPLEEN 1 TESTES %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN 648227 648232 648252 648258 648269 648274 648290 648299 648302 1 15.136 1 16.169 1 12.522 1 16.404 1 14.645 1 15.761 1 16.040 1 15.990 1 16.121 2.6083 2.6248 2.6848 2.8152 2.7554 2.7123 2.7012 2.8097 2.8731 765.22 740.68 606.10 778.55 659.98 717.06 751.99 703.48 747.73 1 1 1 0.869 0.984 0.792 0.955 0.888 1.103 0.855 0.869 0.900 0.1498 43.933 0.1597 45.076 0.1698 38.335 0.1639 45.325 0.1671 40.018 0.1898 50.182 0.1440 40.084 0.1527 38.231 0.1604 41.744 1 1 1 I 1 1 1 3.475 0.5988 175.68 3.342 0.5425 153.09 3.543 0.7596 171.49 3.537 0.6070 167.87 3.523 0.6628 158.77 3.348 0.5761 152.32 3.993 0.6724 187.20 3.657 0.6426 160.89 3.567 0.6357 165.45 THYMUS (Gms) %FBW %BRAIN 0.367 0.0632 18.554 0.382 0.0620 17.499 0.356 0.0763 17.231 0.448 0.0769 21.262 0.347 0.0653 15.638 0.294 0.0506 13.376 0.402 0.0677 18.847 0.362 0.0636 15.926 0.429 0.0765 19.898 THYROID GLAND (Gms) %FBW %BRAIN 0.021 0.0036 1.0617 0.019 0.0031 0.8704 0.024 0.0051 1.1617 0.037 0.0063 1.7561 0.030 0.0056 1.3520 0.022 0.0038 1.0009 0.020 0.0034 0.9376 0.012 0.0021 0.5279 0.015 0.0027 0.6957 FBW - Final Body Weight Company Sanitized. Does not contain TSC CBS H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Organ Weight Listing (90-Day Exposure) Group : III - 60 mg/kg/day (Iso) Treatment : 60 mg/kg/day III Sex :MALES 1 ANIMAL 1 LIVER 1 SPLEEN 1 TESTES 1 THYMUS 1 THYROID GLAND | 1 i(Gins) %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN | I 648303 I 13.873 2.5777 623.51 I I Mean I S.D. I | 15.266 2.7163 709.43 I 1.251 0.0972 60.317 0.545 0.1013 24.494 | 3.843 0.7140 172.72 I 0.876 0.1558 40.742 | 3.583 0.6412 166.55 0.144 0.0230 6.8079 | 0.204 0.0648 10.809 0.311 0.0578 13.978 | I 0.370 0.0660 17.221 | 0.048 0.0086 2.5273 | 0.030 0.0056 1.3483 | 0.023 0.0041 1.0712 | 0.008 0.0014 0.3547 Group : V - 10 mg/kg/day Treatment : 10 mg/kg/day V Sex :MALES ANIMAL 1 1(Gms) LIVER 1 SPLEEN j TESTES 1 THYMUS %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN THYROID GLAND (Gms) %FBW %BRAIN 648221 1 18.669 2.9766 863.11 1 0.908 0.1448 41.979 1 3.798 0.6055 175.59 1 0.286 0.0456 13.222 0.018 0.0029 0.8322 648224 1 13.939 2.5789 665.03 1 0.753 0.1393 35.926 3.844 0.7112 183.40 0.566 0.1047 27.004 0.028 0.0052 1.3359 648245 1 15.998 2.8650 731.84 1 0.786 0.1408 35.956 3.179 0.5693 145.43 0.339 0.0607 15.508 0.020 0.0036 0.9149 648273 1 15.962 2.9138 743.46 0.920 0.1679 42.850 3.106 0.5670 144.67 0.342 0.0624 15.929 0.037 0.0068 1.7233 648286 1 15.647 2.5136 712.52 0.918 0.1475 41.803 3.417 0.5489 155.60 0.426 0.0684 19.399 1 0.028 0.0045 1.2750 648288 1 13.855 2.9046 665.47 0.716 0.1501 34.390 3.272 0.6860 157.16 1 0.239 0.0501 11.479 0.028 0.0059 1.3449 648301 1 16.329 2.9501 758.78 0.968 0.1749 44.981 3.461 0.6253 160.83 1 0.272 0.0491 12.639 1 0.027 0.0049 1.2546 648309 1 12.766 2.2731 588.84 0.802 0.1428 36.993 3.515 0.6259 162.13 0.261 0.0465 12.039 0.023 0.0041 1.0609 648312 1 16.206 2.7046 770.61 1 0.975 0.1627 46.362 3.578 0.5971 170.14 0.315 0.0526 14.979 [ 0.021 0.0035 0.9986 648313 1 17.169 2.6475 766.82 1 0.733 0.1130 32.738 3.701 0.5707 165.30 0.289 0.0446 12.908 0.036 0.0056 1.6079 Mean 11 15.654 2.7328 726.65 1 0.848 0.1484 39.398 j 3.487 0.6107 162.02 1 0.334 0.0585 15.511 j 0.027 0.0047 1.2348 S.D. 1 1.728 0.2303 74.715 1 0.100 0.0174 4.7513 0.252 0.0532 12.295 0.097 0.0181 4.6694 0.006 0.0012 0.2892 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CM H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Organ Weight Listing (90-Day Exposure) Group : VII - 60 mg/kg/day Treatment : 60 mg/kg/day VII Sex :MALES ANIMAL 1 1(Gms) LIVER 1 SPLEEN 1 TESTES %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN 648223 1 18.548 2.9141 888.74 1 1.060 0.1665 50.791 1 3.741 0.5877 179.25 648237 1 19.791 3.1464 927.41 1 0.724 0.1151 33.927 1 3.676 0.5844 172.26 648243 1 14.519 2.6538 681.64 1 0.959 0.1753 45.023 1 4.371 0.7989 205.21 648244 1 14.317 2.7990 645.20 1 0.889 0.1738 40.063 1 3.240 0.6334 146.01 648259 1 17.061 3.0930 793.53 1 0.765 0.1387 35.581 j 3.685 0.6681 171.40 648266 1 18.855 3.0698 907.36 1 0.835 0.1359 40.183 1 4.183 0.6810 201.30 648270 1 13.875 2.7454 655.10 1 0.932 0.1844 44.004 j 3.567 0.7058 168.41 648280 1 14.237 2.6616 635.58 1 0.807 0.1509 36.027 1 3.743 0.6998 167.10 648300 1 12.342 2.8736 635.53 1 0.641 0.1492 33.007 j 4.120 0.9593 212.15 648305 1 17.535 3.0469 774.86 1 0.763 0.1326 33.716 j 3.387 0.5885 149.67 Mean S.D. 1 i 16.108 2.9004 754.50 I 0.838 0.1522 39.232 1 3.771 0.6907 177.28 1 2.548 0.1828 119.56 0.124 0.0223 5.8918 1 0.356 0.1156 22.507 THYMUS 1 THYROID GLAND (Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN 0.327 0.400 0.308 0.460 0.421 0.525 0.350 0.426 0.279 0.543 0.0514 0.0636 0.0563 0.0899 0.0763 0.0855 0.0693 0.0796 0.0650 0.0944 15.668 18.744 14.460 20.730 19.581 25.265 16.525 19.018 14.367 23.995 1 j 1 1 1 1 j j j 1 0.027 0.0042 1.2937 0.029 0.0046 1.3590 0.022 0.0040 1.0329 0.020 0.0039 0.9013 0.041 0.0074 1.9070 0.029 0.0047 1.3956 0.032 0.0063 1.5109 0.021 0.0039 0.9375 0.018 0.0042 0.9269 0.028 0.0049 1.2373 0.404 0.0731 18.835 1 0.027 0.0048 1.2502 0.089 0.0144 3.7509 0.007 0.0012 0.3172 Group : IX - 300 mg/kg/day Treatment : 300 mg/kg/day IX Sex :MALES ANIMAL 1(Gms) LIVER SPLEEN TESTES THYMUS THYROID GLAND %FBW %BRAIN 1(Gms) %FBW %BRAIN I(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN 648217 648218 648235 648236 648239 648248 648275 648289 648293 ! 19.535 3.6290 1 19.669 3.6097 1 19.981 3.7750 ! 18.218 3.6797 1 24.896 3.9605 1 16.595 3.5650 1 15.638 3.5420 1 21.879 3.5657 i 17.418 3.8332 884.34 970.83 916.14 602.65 1158.5 747.19 785.83 934.60 804.90 1 1 1 1 1 1 1 1 1 0.762 1.060 0.789 0.821 0.943 0.821 0.770 0.694 0.705 0.1416 0.1945 0.1491 0.1658 0.1500 0.1764 0.1744 0.1131 0.1551 34.495 52.320 36.176 27.158 43.881 36.965 38.693 29.645 32.579 ! ! 1 1 1 1 1 1 1 3.805 0.7069 172.25 3.516 0.6453 173.54 4.482 0.8468 205.50 3.352 0.6770 110.88 3.599 0.5725 167.47 3.358 0.7214 151.19 3.214 0.7280 161.51 3.801 0.6195 162.37 3.275 0.7207 151.34 1 1 1 1 1 1 1 1 1 0.349 0.597 0.363 0.451 0.489 0.528 0.323 0.336 0.207 0.0648 15.799 0.1096 29.467 0.0686 16.644 0.0911 14.919 0.0778 22.755 0.1134 23.773 0.0732 16.231 0.0548 14.353 0.0456 9.5656 1 1 1 1 1 1 1 1 1 0.017 0.0032 0.7696 0.022 0.0040 1.0859 0.027 0.0051 1.2380 0.025 0.0050 0.8270 0.017 0.0027 0.7911 0.026 0.0056 1.1706 0.009 0.0020 0.4523 0.030 0.0049 1.2815 0.016 0.0035 0.7394 FBW - Final Body Weight 780 Company Sanitized. Does not contain TSCA CBS H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Organ Weight Listing (90-Day Exposure) Group : IX - 300 mg/kg/day Treatment : 300 mg/kg/day IX Sex :MALES | ANIMAL I LIVER | SPLEEN | TESTES | THYMUS | THYROID GLAND | I j(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN | 1 648308 1 1 1 Mean 1 S.D. 1 19.560 1 1 19.339 2.669 3.5448 3.6705 0.1420 881.48 868.64 148.29 1 1 j j 0.904 0.1638 40.739 1 1 0.827 0.1584 37.265 i 0.113 0.0223 7.2697 j 3.863 0.7001 174.09 1 3.627 0.6938 163.01 1 0.381 0.0739 23.898 j 0.392 0.404 0.114 0.0710 0.0770 0.0220 17.666 18.117 5.6877 1 11 1 1 0.032 0.022 0.007 0.0058 1.4421 0.0042 0.9797 0.0013 0.3088 j !I j j FBW - Final Body Weight 781 Company Sanitized. Does not so stain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats___________________________________________________________________________________________ DuPont-6554 Organ Weight Listing (One-Month Recovery) Group : I - 0 mg/kg/day Treatment : 0 mg/kg/day I Sex .-MALES 1 ANIMAL | FBW 1 | (Gms) 1 648216 1 648222 1 648233 1 648250 1 648257 1 648260 1 648264 1 648271 1 648278 1 648311 |496.00 |566.20 |621.50 |627.60 652.50 |665.30 |578.60 |582.30 612.30 |548.70 Mean 1 S.D. |595.10 51.117 BRAIN | ADRENAL GLANDS | EPIDIDYMIDES | (Gms) %FBW | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) HEART KIDNEYS 1 %FBW %BRAIN j (Gms) %FBW %BRAIN 1 2.248 0.4532 | 0.040 0.0081 1.7794 | 1.530 0.3085 68.061 | 1.659 0.3345 73.799 | 3.504 0.7065 155.87 1 2.222 0.3924 j 0.062 0.0110 2.7903 j 1.501 0.2651 67.552 i 2.222 0.3924 100.00 j 3.634 0.6418 163.55 1 2.134 0.3434 j 0.042 0.0068 1.9681 i 1.673 0.2692 78.397 1.962 0.3157 91.940 j 4.076 0.6558 191.00 1 2.223 0.3542 | 0.047 0.0075 2.1143 j 1.511 0.2408 67.971 j 1.772 0.2823 79.712 j 4.403 0.7016 198.07 1 2.186 0.3350 j 0.050 0.0077 2.2873 j 1.478 0.2265 67.612 | 2.029 0.3110 92.818 | 4.484 0.6872 205.12 1 2.138 0.3214 j 0.052 0.0078 2.4322 | 1.547 0.2325 72.357 i 1.926 0.2895 90.084 | 5.121 0.7697 239.52 1 2.243 0.3877 j 0.054 0.0093 2.4075 | 1.539 0.2660 68.613 j 2.064 0.3567 92.020 j 4.335 0.7492 193.27 1 1.984 0.3407 j 0.045 0.0077 2.2681 j 1.594 0.2737 80.343 j 1.777 0.3052 89.567 j 4.102 0.7044 206.75 1 2.060 0.3364 j 0.054 0.0088 2.6214 j 1.564 0.2554 75.922 | 2.317 0.3784 112.48 j 3.893 0.6358 188.98 1 2.002 0.3649 0.034 0.0062 1.6983 j 1.499 0.2732 74.875 i 1.605 0.2925 80.170 \ 3.455 0.6297 172.58 1 Ii 2.144 0.3629 | 0.048 0.0081 2.2367 | 1.544 0.2611 72.170 | 1.933 0.3258 90.258 | 4.101 0.6882 191.47 1 0.099 0.0392 0.008 0.0013 0.3514 \ 0.057 0.0238 4.9021 | 0.234 0.0384 10.982 j 0.513 0.0477 24.005 1 Group : IX - 300 mg/kg/day Treatment : 300 mg/kg/day IX Sex :MALES | ANIMAL | FBW 1 \ (Gms) | 648230 j 648241 | 648249 j 648261 \ 648262 j 648277 | 648282 \ 648284 585.50 637.80 532.50 582.50 531.60 558.70 538.70 531.70 BRAIN j ADRENAL GLANDS ] EPIDIDYMIDES | (Gms) %FBW (Gms) %FBW %BRAIN j (Gms) %FBW %BRAIN | (Gms) HEART KIDNEYS | %FBW %BRAIN j (Gms) %FBW %BRAIN j 2.270 2.134 2.158 2.326 2.275 2.226 2.043 2.034 0.3877 0.3346 0.4053 0.3993 0.4280 0.3984 0.3792 0.3825 | j 0.046 0.053 0.041 0.048 0.059 0.047 0.037 0.041 0.0079 0.0083 0.0077 0.0082 0.0111 0.0084 0.0069 0.0077 2.0264 2.4836 1.8999 2.0636 2.5934 2.1114 1.8111 2.0157 | | 1.483 1.555 1.411 1.499 1.451 1.916 1.426 1.437 0.2533 0.2438 0.2650 0.2573 0.2729 0.3429 0.2647 0.2703 65.330 72.868 65.385 64.445 63.780 86.074 69.799 70.649 | j j j | | j j 1.701 1.895 1.963 1.804 1.874 2.023 1.530 1.677 0.2905 0.2971 0.3686 0.3097 0.3525 0.3621 0.2840 0.3154 74.934 88.800 90.964 77.558 82.374 90.881 74.890 82.448 | \ \ \ j j \ \ 5.145 5.244 4.556 4.352 4.567 3.819 4.013 3.914 0.8787 0.8222 0.8556 0.7471 0.8591 0.6836 0.7449 0.7361 226.65 245.74 211.12 187.10 200.75 171.56 196.43 192.43 | | | j j j j j FBW - Final Body Weight 782 Company Sanitized. Doss not contain TSC CBI )) ) H-24678: Subchronic Toxicity 90-Day Oral Gavage Stiidy in Rats____________________________________________________________________________________________ DuPont-6554 Organ Weight Listing (One-Month Recovery) Group : IX - 300 mg/kg/day Treatment : 300 mg/kg/day IX Sex :MALES 1 ANIMAL 1 FBW 1 BRAIN 1 [ (Gms) 1(Gms) %FBW ADRENAL GLANDS 1 EPIDIDYMIDES | (Gms) %FBW %BRAIN 1 (Gms) %FBW %BRAIN 1 (Gms) HEART 1 KIDNEYS 1 %FBW %BRAIN j (Gms) %FBW %BRAIN 1 1 648306 1 [616.80 1 2.238 0.3628 ; ! 0.035 0.0057 1.5639 1 ! 1.329 0.2155 59.383 1 1 1.733 0.2810 77.435 j 5.193 0.8419 232.04 1 1 !1 Mean [568.42 2.189 0.3864 1 0.045 0.0080 2.0632 1 1.501 0.2651 68.635 1 1.800 0.3179 82.254 1 4.534 0.7966 207.09 1 1 S.D. 39.712 1 0.104 0.0267 0.008 0.0014 0.3169 1 0.168 0.0340 7.7107 0.155 0.0344 6.5791 0.561 0.0693 23.836 j FBW - Final Body Weight 783 Company Sanitized. Doss not contain i SCA CBf ) H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats )) ___________________________________________________________________ DuPont-6554 Organ Weight Listing (One-Month Recovery) Group : I - 0 mg/kg/day Treatment 0 mg/kg/day I Sex :MALES ANIMAL 1 1(Gms) LIVER 1 SPLEEN I TESTES 1 THYMUS 1 THYROID GLAND | %FBW %BRAIN 1(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN | 648216 648222 648233 648250 648257 648260 648264 648271 648278 648311 Mean S.D. 1 12.725 2.5655 566.06 1 1 14.937 2.6381 672.23 j 1 16.793 2.7020 786.93 j 1 18.153 2.8924 816.60 1 1 16.157 2.4762 739.11 j 1 18.565 2.7905 868.33 1 1 14.797 2.5574 659.70 j 1 15.728 2.7010 792.74 j 1 16.854 2.7526 818.16 j 1 13.419 2.4456 670.28 j I1 1 15.813 2.6521 739.01 j 1 1.894 0.1423 94.032 1 0.765 0.1542 34.030 ! 0.901 0.1591 40.549 j 0.729 0.1173 34.161 1 1.005 0.1601 45.209 1 0.870 0.1333 39.799 1 0.847 0.1273 39.616 j 0.807 0.1395 35.979 j 0.804 0.1381 40.524 j 0.909 0.1485 44.126 j 0.745 0.1358 37.213 1 1 0.838 0.1413 39.121 j 0.086 0.0140 3.8132 j 3.385 0.6825 150.58 1 3.584 0.6330 161.30 j 3.282 0.5281 153.80 j 3.428 0.5462 154.21 1 3.749 0.5746 171.50 1 3.791 0.5698 177.32 j 3.512 0.6070 156.58 j 3.559 0.6112 179.39 j 3.621 0.5914 175.78 I 3.264 0.5949 163.04 j 3.518 0.5939 164.35 1 0.180 0.0440 10.808 0.324 0.456 0.292 0.341 0.442 0.298 0.270 0.289 0.352 0.275 0.0653 0.0805 0.0470 0.0543 0.0677 0.0448 0.0467 0.0496 0.0575 0.0501 14.413 20.522 13.683 15.340 20.220 13.938 12.037 14.567 17.087 13.736 1 j j 1 j 1 j j j j 0.334 0.0564 15.554 1 0.066 0.0115 2.8461 1 0.012 0.016 0.028 0.019 0.021 0.019 0.031 0.018 0.025 0.027 0.0024 0.0028 0.0045 0.0030 0.0032 0.0029 0.0054 0.0031 0.0041 0.0049 0.5338 0.7201 1.3121 0.8547 0.9607 0.8887 1.3821 0.9073 1.2136 1.3487 1 j j j 1 j j j j j j 0.022 0.0036 1.0122 1 0.006 0.0010 0.2884 j Group : IX - 300 mg/kg/day Treatment : 300 mg/kg/day IX Sex MALES ANIMAL LIVER (Gms ) %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN TESTES (Gms) %FBW %BRAIN THYMUS (Gms) %FBW %BRAIN THYROID GLAND | (Gms) %FBW %BRAIN | 648230 648241 648249 648261 648262 648277 648282 648284 18.323 3.1295 807.18 19.885 3.1177 931.82 16.148 3.0325 748.29 17.285 2.9674 743.12 16.745 3.1499 736.04 18.653 3.3386 837.96 14.751 2.7383 722.03 14.312 2.6917 703.64 0.893 0.1525 39.339 0.901 0.1413 42.221 0.690 0.1296 31.974 0.749 0.1286 32.201 0.905 0.1702 39.780 0.576 0.1031 25.876 0.701 0.1301 34.312 0.768 0.1444 37.758 3.560 0.6080 156.83 | 0.421 0.0719 18.546 3.914 0.6137 183.41 | 0.563 0.0883 26.382 3.480 0.6535 161.26 j 0.346 0.0650 16.033 4.158 0.7138 178.76 j 0.423 0.0726 18.186 3.763 0.7079 165.41 | 0.451 0.0848 19.824 3.561 0.6374 159.97 | 0.314 0.0562 14.106 3.786 0.7028 185.32 j 0.269 0.0499 13.167 3.314 0.6233 162.93 | 0.364 0.0685 17.896 0.021 0.0036 0.9251 0.017 0.0027 0.7966 0.026 0.0049 1.2048 0.026 0.0045 1.1178 0.025 0.0047 1.0989 0.016 0.0029 0.7188 0.027 0.0050 1.3216 0.018 0.0034 0.8850 FBW - Final Body Weight 784 Company Sanitized. Does not contain TSCA CBi )) H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats____________________________________________________________________________________________ DuPont-6554 Organ Weight Listing (One-Month Recovery) Group : IX - 300 mg/kg/day Treatment : 300 mg/kg/day IX Sex :MALES 1 ANIMAL ! 1 1(Gms) LIVER 1 SPLEEN I TESTES [ THYMUS 1 THYROID GLAND | %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW '%BRAIN 1(Gms) %FBW %BRAIN 1 1 648306 1 23.343 3.7845 1043.0 1 0.807 0.1308 36.059 1 3.450 0.5593 154.16 1 0.648 0.1051 28.954 1 0.024 0.0039 1.0724 | 1! 1 1 1 11 1 Mean 1 17.716 3.1056 808.12 1 0.777 0.1367 35.502 1 3.665 0.6466 167.56 1 0.422 0.0736 19.233 1 0.022 0.0039 1.0157 1 1 S.D. 1 2.774 0.3257 113.30 1 0.112 0.0186 5.0124 1 0.263 0.0528 11.780 1 0.120 0.0170 5.2755 1 0.004 0.0009 0.1973 1 FBW - Final Body Weight 785 Company Sanitized. Does not contain TSCA C8l H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Organ Weight Listing (Three-Month Recovery) Group : I - 0 mg/kg/day Treatment : 0 mg/kg/day I Sex :MALES 1 ANIMAL 1 FBW 1 KIDNEYS 1 1 (Oms) j(Gms) %FBW 1 648219 1 648226 1 648228 1 648297 1 648298 1 Mean 1 S.D. 1502.80 1 600.00 j 505.00 1 648.90 j [554.50 j !1 [562.24 [ 62.859 j 3.146 0.6257 4.093 0.6822 3.573 0.7075 3.688 0.5683 3.937 0.7100 3.687 0.6587 0.365 0.0609 1 LIVER j(Gms) %FBW 1 12.402 2.4666 j 15.621 2.6035 1 12.165 2.4089 j 16.914 2.6066 1 13.637 2.4593 1 14.148 2.5090 j 2.065 0.0905 1 TESTES 1(Gms) %FBW 1 3.880 0.7717 j 3.735 0.6225 1 3.345 0.6624 j 3.657 0.5636 j 4.019 0.7248 1 1 3.727 0-6690 j 0.255 0.0821 Group : V - 10 mg/kg/day Treatment 1 ANIMAL 1 FBW [ KIDNEYS 1 1 (Gms) \ (Gms) %FBW 1 648253 1659.60 1 3.982 0.6037 1 648254 534.60 1 4.650 0.8698 1 648265 610.20 1 3.750 0.6146 1 648283 \ 560.50 j 3.761 0.6710 1 648310 [618.50 j 3.785 0.6120 11 11 1 Mean [596.68 [ 3.986 0.6742 1 S.D. 49.449 \ 0.383 0.1126 10 mg/kg/day V Sex :MALES 1 1(Gms) LIVER %FBW I TESTES 1(Gms) %FBW 1 16.536 2.5070 \ 17.076 3.1942 \ 14.914 2.4441 1 15.691 2.7995 j 16.789 2.7145 1 1 16.201 2.7318 \ 0.886 0.2966 1 3.309 0.5017 j 3.608 0.6749 3.416 0.5598 \ 3.808 0.6794 j 2.993 0.4839 1 j 3.427 0.5799 1 0.308 0.0931 1 THYROID GLAND 1(Gms) %FBW 1 0.023 0.0046 \ 0.022 0.0037 1 0.018 0.0036 1 0.026 0.0040 1 0.023 0.0041 1I [ 0.022 0.0040 j 0.003 0.0004 | 1 1 \ 1 j j 1 j 1 THYROID GLAND 1(Gms) %FBW 1 0.027 0.0041 \ 0.022 0.0041 1 0.022 0.0036 1 0.027 0.0048 j 0.025 0.0040 1 0.025 0.0041 j 0.003 0.0004 | 1 1 \ 1 j j 1 j DuPont-6554 FBW - Final Body Weight ) H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats ) ______________________________________________ DuPont-6554 Organ Weight Listing (Three-Month Recovery) Group : VII - 60 mg/kg/day Treatment : 60 mg/kg/day VII Sex MALES 1 ANIMAL | FBW KIDNEYS 1 | (Gms} (Gms) %FBW 1 |(Gms) LIVER %FBW | TESTES i(Gms) %FBW ! 648268 1 648279 1 648285 1 648296 1 648314 |712.40 586.70 522.80 628.20 494.70 Mean 1 S.D. |588.96 86.667 4.706 0.6606 4.067 0.6932 2.865 0.5480 3.425 0.5452 13.136 2.6553 5.640 1.0205 4.247 0.9163 | 21.487 3.0161 j 14.747 2.5136 \ 11.207 2.1436 j 18.917 3.0113 | 21.527 4.3515 ! | 17.577 3.0072 \ 4.508 0.8362 | 3.829 0.5375 \ 3.318 0.5655 \ 3.424 0.6549 | 3.234 0.5148 | 3.061 0.6188 1 | 3.373 0.5783 i 0.287 0.0578 Group : IX - 300 mg/kg/day Treatment : 300 mg/kg/day IX Sex MALES ANIMAL | FBW 1 KIDNEYS [ (Gms) 1(Gms) %FBW LIVER |(Gms) %FBW | TESTES j(Gms) %FBW 648234 |684.80 1 5.890 0.8601 648240 |548.50 1 4.113 0.7499 648272 535.60 1 3.543 0.6615 648287 |649.90 1 4.640 0.7140 648292 |634.10 11 1 1 4.584 0.7229 Mean |610.58 1 4.554 0.7417 S.D. |65.352 ! 0.867 0.0736 | 19.427 2.8369 | 13.792 2.5145 j 14.755 2.7549 j 19.743 3.0379 j 16.743 2.6404 I | 16.892 2.7569 \ 2.681 0.1985 | 3.935 0.5746 j 3.460 0.6308 \ 3.814 0.7121 i 3.558 0.5475 j 3.561 0.5616 1 | 3.666 0.6053 j 0.200 0.0676 | THYROID GLAND \ (Gms) %FBW | 0.037 0.0052 | 0.018 0.0031 i 0.018 0.0034 i 0.022 0.0035 | 0-026 0.0053 [ | 0.024 0.0041 \ 0.008 0.0010 1 I ! 1 i i ! 1 1 1 | THYROID GL |(Gms) %FBW | 0.024 0.0035 j 0.022 0.0040 \ 0.014 0.0026 \ 0.024 0.0037 i 0.023 0.0036 1 1 0.021 0.0035 i 0.004 0.0005 FBW - Final Body Weight 787 nnasw San't'zed. Do ""t copain TSCA ffl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Organ Weight Listing (90-Day Exposure) DuPont-6554 Group : II - 0 mg/kg/day Treatment : 0 mg/kg/day II Sex :FEMALES ANIMAL | FBW BRAIN | ADRENAL GLANDS | j (Gms) (Gms) %FBW | (Gms) %FBW %BRAIN \ (Gms) HEART 1 KIDNEYS | %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) LIVER 1 %FBW %BRAIN | 648351 648353 648370 648372 648393 648395 648421 648423 648430 648436 297.70 307.20 285.80 337.80 \ 305.50 272.90 349.00 319.40 301.00 315.50 Mean S.D. 309.18 22.677 1.843 1.838 1.916 1.960 1.813 1.739 2.041 2.008 2.113 1.992 0.6191 0.5983 0.6704 0.5802 0.5935 0.6372 0.5848 0.6287 0.7020 0.6314 | j | j j | j | \ 1.926 0.6246 | 0.117 0.0388 \ 0.061 0.076 0.072 0.074 0.070 0.044 0.071 0.064 0.073 0.048 0.0205 0.0247 0.0252 0.0219 0.0229 0.0161 0.0203 0.0200 0.0243 0.0152 3.3098 4.1349 3.7578 3.7755 3.8610 2.5302 3.4787 3.1873 3.4548 2.4096 | j \ j j j j j j j 1 0.065 0.0211 3.3900 j 0.011 0.0034 0.5598 j 1.304 1.171 0.980 1.184 1.091 1.165 1.255 1.635 1.295 1.105 1.219 0.176 0.4380 0.3812 0.3429 0.3505 0.3571 0.4269 0.3596 0.5119 0.4302 0.3502 0.3949 0.0551 70.754 63.711 51.148 60.408 60.177 66.993 61.489 81.424 61.287 55.472 63.286 8.3815 | | j j \ j j j j | 11 | \ 2.426 0.8149 131.63 2.167 0.7054 117.90 1.955 0.6840 102.04 2.442 0.7229 124.59 1.993 0.6524 109.93 2.291 0.8395 131.74 2.169 0.6215 106.27 2.478 0.7758 123.41 2.264 0.7522 107.15 2.003 0.6349 100.55 2.219 0.7203 115.52 0.194 0.0749 11.859 | 8.837 j 9.135 | 7.525 j 11.066 i 7.880 j 7.523 \ 9.496 | 9.015 \ 8.450 j 7.860 j1 | 8.679 | 1.092 2.9684 2.9736 2.6330 3.2759 2.5794 2.7567 2.7209 2.8225 2.8073 2.4913 2.8029 0.2274 479.49 497.01 392.75 564.59 434.64 432.60 465.26 448.95 399.91 394.58 450.98 53.575 | | j j | i j | | j j1 | i Group : IV - 60 mg/kg/day (Iso) Treatment : 60 mg/kg/day IV Sex :FEMALES ANIMAL I FBW BRAIN I (Gms ) (Gms) %FBW ADRENAL G] HEART (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN 648364 648369 648390 648396 648397 648402 648408 648409 315.20 303.70 317.70 307.90 284.80 308.50 282.30 317.20 2.023 0.6418 2.011 0.6622 1.865 0.5870 1.828 0.5937 1.873 0.6577 2.003 0.6493 1.865 0.6606 1.910 0.6021 0.073 0.056 0.061 0.063 0.078 0.062 0.071 0.052 0.0232 0.0184 0.0192 0.0205 0.0274 0.0201 0.0252 0.0164 3.6085 2.7847 3.2708 3.4464 4.1644 3.0954 3.8070 2.7225 | 1.212 0.3845 59.911 1.059 0.3487 52.660 1.134 0.3569 60.804 1.174 0.3813 64.223 1.196 0.4199 63.855 1.128 0.3656 56.316 1.099 0.3893 58.928 1.142 0.3600 59.791 (Gms) %FBW %BRAIN | (Gms) LIVER I %FBW %BRAIN i 2.103 0.6672 103 95 | 9 357 2.9686 462.53 2.029 0.6681 100 90 j 7 624 2.5104 379.11 2.257 0.7104 121 02 j 9 164 2.8845 491.37 2.529 0.8214 138 35 i 9 297 3.0195 508.59 2.367 0.8311 126 37 i 8 419 2.9561 449.49 2.305 0.7472 115 08 j 9 036 2.9290 451.12 2.028 0.7184 108 74 \ 7 657 2.7124 410.56 2.118 0.6677 110 89 | 8 233 2.5955 431.05 FBW - Final Body Weight 788 Company Sanitized. Does not contain TSC CB1 ) H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats ) ) DuPont-6554 Organ Weight Listing (90-Day Exposure) Group : IV - 60 mg/kg/day (Iso) Treatment : 60 mg/kg/day IV Sex :FEMALES ANIMAL I FBW I BRAIN I (Gins) I(Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN (Gms) HEART %FBW %BRAIN 648410 1329.10 1.992 0.6053 648424 I292.90 1.963 0.6702 0.077 0.0234 3.8655 0.065 0.0222 3.3113 1.329 0.4038 66.717 1.020 0.3482 51.961 Mean 1305.93 | 1.933 0.6330 S.D. 115.197 I 0.073 0.0322 0.066 0.0216 3.4076 0.009 0.0033 0.4675 1.149 0.3758 59.517 0.086 0.0241 4.8234 KIDNEYS (Gms) %FBW %BRAIN 2.474 0.7517 124.20 2.187 0.7467 111.41 2.240 0.7330 116.09 0.178 0.0594 11.418 LIVER I (Gms) %FBW %BRAIN j 8.991 2.7320 451.36 9.574 3.2687 487.72 8.735 2.8577 452.29 0.707 0.2234 38.893 | j I | | Group : VI - 10 mg/kg/day Treatment 10 mg/kg/day VI Sex :FEMALES ANIMAL 1 FBW 1 BRAIN I (Gms) 1(Gms) %FBW ADRENAL GLANDS | (Gms) %FBW %BRAIN | (Gms) HEART 1 KIDNEYS 1 %FBW %BRAIN 1 (Gms) %FBW %BRAIN j (Gms) LIVER %FBW %BRAIN 648345 648366 648374 648382 648403 648406 648414 648429 648433 648441 Mean S.D. 1254.80 1339.60 1290.00 284.20 278.90 1295.10 289.90 305.20 274.20 327.80 11 1293.97 25.020 1 2.006 0.7873 1 1.937 0.5704 1 1.861 0.6417 1 1.996 0.7023 1 1.870 0.6705 i 1.852 0.6276 1 1.960 0.6761 ! 1.724 0.5649 1 1.813 0.6612 1 1.873 0.5714 ! 1.889 0.6473 1 0.087 0.0692 11 1 0.058 0.0228 2.8913 0.076 0.0224 3.9236 0.051 0.0176 2.7405 0.077 0.0271 3.8577 0.061 0.0219 3.2620 0.080 0.0271 4.3197 0.069 0.0238 3.5204 0.059 0.0193 3.4223 0.082 0.0299 4.5229 0.064 0.0195 3.4170 1 i i j j j j j 1 i 0.068 0.0231 3.5877 1 0.011 0.0039 0.5741 j 0.900 0.3532 1.109 0.3266 1.135 0.3914 1.033 0.3635 1.002 0.3593 1.043 0.3534 1.172 0.4043 1.029 0.3372 1.091 0.3979 1.048 0.3197 1.056 0.3606 0.076 0.0293 44.865 57.253 60.989 51.754 53.583 56.317 59.796 59.687 60.177 55.953 56.037 4.9424 1 i j 2.068 2.334 2.345 2.170 2.379 2.207 2.261 2.214 2.337 2.171 0.8116 0.6873 0.8086 0.7635 0.8530 0.7479 0.7799 0.7254 0.8523 0.6623 103.09 120.50 126.01 108.72 127.22 119.17 115.36 128.42 128.90 115.91 1 i i i j j i 1 j j 2.249 0.7692 119.33 1 0.100 0.0649 8.7326 1 7.374 2.8940 367.60 9.557 2.8142 493.39 8.347 2.8783 448.52 8.932 3.1429 447.49 6.609 2.3697 353.42 8.057 2.7303 435.04 8.443 2.9124 430.77 7.810 2.5590 453.02 7.783 2.8384 429.29 7.614 2.3228 406.51 8.053 2.7462 426.51 0.826 0.2569 41.381 FBW - Final Body Weight 789 Company Sanitized. Does not contain TSCA CB )) H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats____________________________________________________________________________ > DuPont-6554 Organ Weight Listing (90-Day Exposure) Group : VIII - 60 mg/kg/day Treatment : 60 mg/kg/day VIII Sex iFEMALES ANIMAL 1 FBW I BRAIN 1 (Gins) 1(Gms) %FBW 648348 648354 648362 648368 648380 648381 648401 648417 648432 648440 Mean S.D. [342.60 263.40 280.70 296.30 340.90 288.00 293.30 293.90 387.00 1375.00 i 1316.11 42.214 1 1.996 1 2.008 1 1.925 1 2.047 1 2.036 1 2.002 1 1.900 1 1.852 1 2.021 1 1.965 ! 1 1.975 1 0.064 0.5826 0.7623 0.6858 0.6909 0.5972 0.6951 0.6478 0.6301 0.5222 0.5240 0.6338 0.0781 ADRENAL GLANDS | (Gms) %FBW %BRAIN (Gms) HEART 1 KIDNEYS 1 %FBW %BRAIN j (Gms) %FBW %BRAIN 1 (Gms) LIVER 1 %FBW %BRAIN 1 0.080 0.0234 4.0080 0.065 0.0247 3.2371 0.073 0.0260 3.7922 0.075 0.0253 3.6639 0.065 0.0191 3.1925 0.083 0.0288 4.1459 0.056 0.0191 2.9474 0.047 0.0160 2.5378 0.074 0.0191 3.6616 0.077 0.0205 3.9186 0.070 0.0222 3.5105 0.011 0.0040 0.5145 1.071 0.3126 53.657 1 0.920 0.3493 45.817 1.085 0.3865 56.364 1.160 0.3915 56.668 ! 1.191 0.3494 58.497 1.040 0.3611 51.948 1.098 0.3744 57.789 1.173 0.3991 63.337 1.466 0.3788 72.538 1.326 0.3536 67.481 1.153 0.3656 58.410 0.153 0.0258 7.7224 2.446 0.7140 122.55 2.005 0.7612 99.851 2.575 0.9173 133.77 2.274 0.7675 111.09 2.518 0.7386 123.67 2.033 0.7059 101.55 2.333 0.7954 122.79 2.198 0.7479 118.68 2.666 0.6889 131.91 2.468 0.6581 125.60 2.352 0.7495 119.15 0.224 0.0715 11.599 1 10.258 2.9942 513.93 1 8.593 3.2623 427.94 1 9.313 3.3178 483.79 1 8.872 2.9943 433.41 1 9.356 2.7445 459.53 1 8.281 2.8753 413.64 1 8.307 2.8323 437.21 1 7.728 2.6295 417.28 1 11.405 2.9470 564.32 1 10.429 2.7811 530.74 9.254 2.9378 468.18 1 1.144 0.2181 52.622 I 1 1 1 1 1 I 1 1 1 j1 1 Group : X - 300 mg/kg/day Treatment : 300 mg/kg/day X Sex :FEMALES ANIMAL j FBW 1 BRAIN 1 ADRENAL GLANDS | j (Gms) j(Gms) %FBW j (Gms) %FBW %BRAIN j (Gms) HEART KIDNEYS 1 %FBW %BRAIN 1 (Gms) %FBW %BRAIN 1 (Gms) LIVER %FBW %BRAIN 648347 648363 648376 648388 648392 648400 648407 648412 648435 1319.20 343.50 340.20 318.40 1300.50 331.80 303.10 268.90 375.90 1 2.101 0.6582 2.078 0.6049 2.005 0.5894 1 1.945 0.6109 1 2.016 0.6709 j 2.023 0.6097 j 1.935 0.6384 j 1.952 0.7259 2.055 0.5467 1 j 1 i 0.056 0.0175 2.6654 0.096 0.0279 4.6198 0.074 0.0218 3.6908 0.074 0.0232 3.8046 0.067 0.0223 3.3234 0.093 0.0280 4.5971 0.064 0.0211 3.3075 0.058 0.0216 2.9713 0.079 0.0210 3.8443 1.587 0.4972 75.535 1 2.554 0.8001 121.56 1 9.862 3.0896 469.40 1.261 0.3671 60.683 j 2.540 0.7394 122.23 1 10.864 3.1627 522.81 1.186 0.3486 59.152 j 2.565 0.7540 127.93 I 10.284 3.0229 512.92 1.266 0.3976 65.090 j 2.411 0.7572 123.96 1 9.691 3.0437 498.25 1.085 0.3611 53.819 j 2.449 0.8150 121.48 1 9.319 3.1012 462.25 1.057 0.3186 52.249 j 2.614 0.7878 129.21 1 8.667 2.6121 428.42 1.148 0.3788 59.328 j 2.353 0.7763 121.60 1 9.161 3.0224 473.44 0.978 0.3637 50.102 j 2.181 0.8111 111.73 1 8.477 3.1525 434.27 1.254 0.3336 61.022 j 2.669 0.7100 129.88 1 11.943 3.1772 581.17 FBW - Final Body Weight 790 Company Sanitized. Does not contain TSCA CBl )) ) H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats____________________________________________________________________________________________ DuPont-6554 Organ Weight Listing (90-Day Exposure) Group : X - 300 mg/kg/day Treatment : 300 mg/kg/day X Sex :FEMALES [ ANIMAL | FBW | BRAIN | ADRENAL GLANDS I 1 | (Gms) |(Gms) %FBW | (Gms) %FBW %BRAIN | (Gms) HEART 1 KIDNEYS 1 %FBW %BRAIN 1 (Gms) %FBW %BRAIN I (Gms) LIVER 1 %FBW %BRAIN [ | 648438 1326.40 | 1.845 0.5653 | 0.068 0.0208 3.6856 ] 1.036 0.3174 56.152 | 2.326 0.7126 126.07 | 10.122 3.1011 548.62 | 11 11 11 11 1 i 1 1 | Mean |322.79 | 1.996 0.6220 J 0.073 0.0225 3.6510 | 1.186 0.3684 59.313 | 2.466 0.7664 123.57 | 9.839 3.0485 493.15 | S.D. |28.805 | 0.077 0.0530 | 0.013 0.0032 0.6286 | 0.174 0.0520 7.2745 | 0.150 0.0381 5.2840 | 1.040 0.1631 49.085 | FBW - Final Body Weight 791 Company Sanitized. Does not contain TSCA CBl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Organ Weight Listing (90-Day Exposure) DuPont-6554 Group : II - 0 mg/kg/day Treatment : 0 mg/kg/day II Sex :FEMALES ANIMAL OVARIES I SPLEEN (Guts) %FBW %BRAIN |(Gms) %FBW %BRAIN THYMUS (Gms) %FBW %BRAIN THYROID GLAND (Gms) %FBW %BRAIN UTERUS (Gms) %FBW %BRAIN 648351 1 0.122 0.0410 6.6196 1 0.577 0.1938 31.308 1 0.279 0.0937 15.138 1 0.015 0.0050 0.8139 1 0.792 0.2660 42.973 648353 1 0.136 0.0443 7.3993 1 0.525 0.1709 28.564 1 0.329 0.1071 17.900 1 0.017 0.0055 0.9249 1 0.529 0.1722 28.781 648370 1 0.130 0.0455 6.7850 j 0.485 0.1697 25.313 I 0.252 0.0882 13.152 1 0.024 0.0084 1.2526 1 0.987 0.3453 51.514 648372 1 0.085 0.0252 4.3367 j 0.543 0.1607 27.704 1 0.331 0.0980 16.888 1 0.019 0.0056 0.9694 1 1.397 0.4136 71.276 648393 1 0.134 0.0439 7.3911 j 0.559 0.1830 30.833 1 0.314 0.1028 17.319 1 0.017 0.0056 0.9377 1 0.673 0.2203 37.121 648395 1 0.115 0.0421 6.6130 j 0.461 0.1689 26.509 1 0.250 0.0916 14.376 1 0.015 0.0055 0.8626 1 0.556 0.2037 31.972 648421 1 0.145 0.0415 7.1044 j 0.597 0.1711 29.250 1 0.278 0.0797 13.621 1 0.018 0.0052 0.8819 1 0.595 0.1705 29.152 648423 1 0.103 0.0322 5.1295 j 0.571 0.1788 28.436 1 0.332 0.1039 16.534 1 0.022 0.0069 1.0956 1 1.198 0.3751 59.661 648430 1 0.096 0.0319 4.5433 j 0.545 0.1811 25.793 1 0.320 0.1063 15.144 1 0.015 0.0050 0.7099 i 0.702 0.2332 33.223 648436 1 !1 0.103 0.0326 5.1707 1 1 1 0.440 0.1395 22.088 11 1 0.378 0.1198 18.976 1 j 1 0.017 0.0054 0.8534 1 1 0.496 0.1572 24.900 Mean 1 0.117 0.0380 6.1093 1 0.530 0.1717 27.580 1 0.306 0.0991 15.905 1 0.018 0.0058 0.9302 1 0.793 0.2557 41.057 S.D. 1 0.020 0.0069 1.1881 1 0.052 0.0146 2.7612 1 0.041 0.0114 1.9169 1 0.003 0.0011 0.1519 1 0.306 0.0917 15.221 Group : IV - 60 mg/kg/day (Iso) Treatment : 60 mg/kg/day IV Sex :FEMALES ANIMAL ! OVARIES 1{Gms) %FBW %BRAIN 648364 ! 648369 1 648390 1 648396 ! 648397 1 648402 1 648408 1 648409 1 0.101 0.0320 4.9926 0.104 0.0342 5.1716 0.119 0.0375 6.3807 0.140 0.0455 7.6586 0.104 0.0365 5.5526 0.197 0.0639 9.8352 0.155 0.0549 8.3110 0.142 0.0448 7.4346 SPLEEN (Gms) %FBW %BRAIN 0.525 0.1666 25.952 0.508 0.1673 25.261 0.564 0.1775 30.241 0.515 0.1673 28.173 0.413 0.1450 22.050 0.502 0.1627 25.062 0.455 0.1612 24.397 0.635 0.2002 33.246 THYMUS (Gms) %FBW %BRAIN THYROID GLAND | UTERUS (Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN 0.270 0.0857 13.347 0.022 0.0070 1.0875 1 0.697 0.2211 34.454 0.251 0.0826 12.481 0.017 0.0056 0.8454 j 0.405 0.1334 20.139 0.313 0.0985 16.783 0.019 0.0060 1.0188 j 0.576 0.1813 30.885 0.319 0.1036 17.451 0.018 0.0058 0.9847 j 0.656 0.2131 35.886 0.249 0.0874 13.294 I 0.016 0.0056 0.8542 j 0.769 0.2700 41.057 0.308 0.0998 15.377 0.014 0.0045 0.6990 j 0.415 0.1345 20.719 0.292 0.1034 15.657 0.016 0.0057 0.8579 j 0.706 0.2501 37.855 0.338 0.1066 17.696 0.015 0.0047 0.7853 j 0.579 0.1825 30.314 FBW - Final Body Weight 792 Company Sanitized. Does not contain TSCA C8 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Organ Weight Listing (90-Day Exposure) Group : IV - 60 mg/kg/day (Iso) Treatment : 60 mg/kg/day IV Sex :FEMALES I ANIMAL I OVARIES I I(Gms) %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN THYMUS (Gms) %FBW %BRAIN THYROID GLAND | UTERUS | (Gms) %FBW %BRAIN ](Gms) %FBW %BRAIN | I 648410 I 0.159 0.0483 7.9819 [ 0.601 0.1826 30.171 I 648424 I 0.092 0.0314 4.6867 I 0.446 0.1523 22.720 I Mean I I 0.131 0.0429 6.8006 I 0.516 0.1683 26.727 0.033 0.0106 1.7045 I 0.069 0.0156 3.6159 0.200 0.0608 10.040 0.216 0.0737 11.004 0.276 0.0902 14.313 0.046 0.0149 2.6847 0.016 0.0049 0 8032 I 0.020 0.0068 1 0188 I I 0.017 0.0057 0 8955 I 0.002 0.0008 0 1248 I 1.019 0.3096 51.155 0.587 0.2004 29.903 0.641 0.2096 33.237 0.178 0.0563 9.2224 | | I | | Group : VI - 10 mg/kg/day Treatment : 10 mg/kg/day VI Sex :FEMALES | ANIMAL | OVARIES | SPLEEN | THYMUS | THYROID GLAND | UTERUS | 1 i(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN i(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN j | 648345 1 648366 | 648374 | 648382 I 648403 | 648406 | 648414 | 648429 | 648433 | 648441 ! \ Mean ! s.D. | | | | | | | j | j i | 1 0.091 0.171 0.106 0.163 0.091 0.172 0.111 0.131 0.151 0.125 0.0357 0.0504 0.0366 0.0574 0.0326 0.0583 0.0383 0.0429 0.0551 0.0381 4.5364 8.8281 5.6959 8.1663 4.8663 9.2873 5.6633 7.5986 8.3287 6.6738 | [ [ | | | [ j 1 j 1 0.131 0.0445 6.9645 j 0.032 0.0098 1.7082 [ 0.400 0.668 0.462 0.477 0.580 0.503 0.452 0.552 0.509 0.423 0.1570 0.1967 0.1593 0.1678 0.2080 0.1705 0.1559 0.1809 0.1856 0.1290 19.940 34.486 24.825 23.898 31.016 27.160 23.061 32.019 28.075 22.584 | | j | | | | | | | 0.503 0.1711 26.706 | 0.080 0.0228 4.6772 | 0.240 0.311 0.292 0.380 0.213 0.336 0.322 0.243 0.321 0.250 0.0942 11.964 0.0916 16.056 0.1007 15.690 0.1337 19.038 0.0764 11.390 0.1139 18.143 0.1111 16.429 0.0796 14.095 0.1171 17.705 0.0763 13.348 | | | j | | | j | j 0.291 0.0994 15.386 | 0.053 0.0194 2.6128 | 0.015 0.0059 0.7478 | 0.023 0.0068 1.1874 [ 0.017 0.0059 0.9135 j 0.016 0.017 0.017 0.014 0.025 0.013 0.016 0.0056 0.0061 0.0058 0.0048 0.0082 0.0047 0.0049 0.8016 0.9091 0.9179 0.7143 1.4501 0.7170 0.8542 I j j | | j j ! 0.017 0.0059 0.9213 | 0.004 0.0010 0.2319 | 0.600 0.2355 29.910 0.570 0.1678 29.427 0.535 0.1845 28.748 0.711 0.2502 35.621 0.664 0.2381 35.508 1.285 0.4354 69.384 0.574 0.1980 29.286 0.549 0.1799 31.845 1.027 0.3745 56.646 0.659 0.2010 35.184 0.717 0.2465 38.156 0.245 0.0889 13.706 | | | | | j j | | | 11 | | FBW - Final Body Weight 793 Company Sanitized. Does not contain TSC CBS Company fS a^ f^ d T^om **contain TSCA CBf H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Organ Weight Listing (90-Day Exposure) Group : VIII - 60 mg/kg/day Treatment : 60 mg/kg/day VIII Sex :FEMALES | ANIMAL | OVARIES | SPLEEN | THYMUS | THYROID GLAND | UTERUS | | |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN j 648348 1 0.172 0.0502 8.6172 I 0.661 0.1929 33 .116 1 0..320 0.0934 16.032 I 0.017 0.0050 0.8517 | 0.717 0.2093 35.922 | 648354 1 0 . 1 2 0 0.0456 5.9761 I 0.503 0.1910 25 .050 j 0..218 0.0828 10.857 I 0.014 0.0053 0.6972 j 0.598 0.2270 29.781 | 648362 1 0.146 0.0520 7.5844 j 0.582 0.2073 30 .234 j 0..382 0.1361 19.844 I 0.020 0.0071 1.0390 | 0.724 0.2579 37.610 | 648368 1 0.149 0.0503 7.2789 I 0.594 0.2005 29 .018 j 0..170 0.0574 8.3048 j 0.023 0.0078 1.1236 | 0.828 0.2794 40.449 | 648380 j 0.130 0.0381 6.3851 I 0.604 0.1772 29 .666 j 0..307 0.0901 15.079 j 0.017 0.0050 0.8350 | 0.597 0.1751 29.322 j 648381 j 0.167 0.0580 8.3417 j 0.449 0.1559 22 .428 j 0..182 0.0632 9.0909 I 0.016 0.0056 0.7992 | 0.595 0.2066 29.720 | 648401 j 0.131 0.0447 6.8947 j 0.476 0.1623 25 .053 j 0..355 0.1210 18.684 j 0.024 0.0082 1.2632 | 1.151 0.3924 60.579 | 648417 j 0.094 0.0320 5.0756 j 0.524 0.1783 28 .294 j 0..427 0.1453 23.056 I 0.016 0.0054 0.8639 | 0.836 0.2845 45.140 | 648432 1 0.091 0.0235 4.5027 I 0.559 0.1444 27 .660 j 0 .391 0.1010 19.347 j 0.019 0.0049 0.9401 | 0.827 0.2137 40.920 | 648440 j 0.195 0.0520 9.9237 j 0.692 0.1845 35 .216 j 0 .478 0.1275 24.326 j 0.022 0.0059 1.1196 | 0.860 0.2293 43.766 | I II! I 1 t 1 Mean | 0.140 0.0446 7.0580 I 0.564 0.1794 28 .573 I 0 .323 0.1018 16.462 I 0.019 0.0060 0.9532 j 0.773 0.2475 39.321 | S.D. 0.033 0.0105 1.6575 j 0.078 0.0201 3.8356 I 0..105 0.0301 5.6215 j 0.003 0.0012 0.1770 0.170 0.0612 9.4692 | Group : X - 300 mg/kg/day Treatment : 300 mg/kg/day X Sex :FEMALES | ANIMAL I OVARIES | SPLEEN | THYMUS | THYROID GLAND | UTERUS | I j(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN | 648347 648363 648376 648388 648392 648400 648407 648412 648435 j j j j j j j j 0.098 0.144 0.135 0.093 0.135 0.148 0.111 0.113 0.118 0.0307 0.0419 0.0397 0.0292 0.0449 0.0446 0.0366 0.0420 0.0314 4 6644 6 9297 6 7332 4 7815 6 6964 7 3159 5 7364 5 7889 5 7421 I j j I j I j I I 0.588 0.621 0.454 0.509 0.574 0.545 0.430 0.361 0.717 0.1842 27 987 0.1808 29 885 0.1335 22 643 0.1599 26 170 0.1910 28 472 0.1643 26 940 0.1419 22 222 0.1343 18 494 0.1907 34 891 I j j j I I I I 0.429 0.1344 20.419 0.315 0.0917 15.159 0.453 0.1332 22.594 0.299 0.0939 15.373 0.292 0.0972 14.484 0.371 0.1118 18.339 0.232 0.0765 11.990 0.245 0.0911 12.551 0.412 0.1096 20.049 I I I j j j I j j 0.018 0.017 0.017 0.019 0.017 0.021 0.034 0.017 0.020 0.0056 0.8567 0.0049 0.8181 0.0050 0.8479 0.0060 0.9769 0.0057 0.8433 0.0063 1.0381 0.0112 1.7571 0.0063 0.8709 0.0053 0.9732 I j j j j I I I j 0.765 0.2397 36.411 | 0.641 0.1866 30.847 | 0.551 0.1620 27.481 | 0.784 0.2462 40.308 j 0.815 0.2712 40.427 | 0.541 0.1631 26.742 j 0.762 0.2514 39.380 | 1.310 0.4872 67.111 j 0.749 0.1993 36.448 | FBW - Final Body Weight 794 Company Sanitized. Does not contain TSC C H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Organ Weight Listing (90-Day Exposure) Group : X - 300 mg/kg/day Treatment : 300 mg/kg/day X Sex :FEMALES 1 ANIMAL 1 OVARIES 1 SPLEEN 1 THYMUS 1 THYROID GLAND | UTERUS 1 1 (Gms ) %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW !fcBRAIN 1 1 648438 1 1 1 Mean 1 S.D. 1 1 [ 0.135 0.0414 7.3171 1 1 0.123 0.0382 6.1706 1 0.019 0.0059 0.9725 [ 0.575 0.1762 31.165 1 1 0.537 0.1657 26.887 1 0.103 0.0226 4.7819 1 0.323 0.0990 17.507 1 1 0.337 0.1038 16.846 1 0.076 0.0186 3.5174 1 0.022 0.0067 1.1924 i ! 0.020 0.0063 1.0175 1 0.005 0.0018 0.2844 1 0.684 0.2096 37.073 0.760 0.2416 38.223 0.215 0.0941 11.325 1 jI j j FBW - Final Body Weight 795 Company Sanitized. Does not contain TSCA CBf H-24678: Subcbronic Toxicity 90-Day Oral Gavage Study in Rats Organ Weight Listing (One-Month Recovery) DuPont-6554 Group : II - 0 mg/kg/day Treatment : 0 mg/kg/day II Sex :FEMALES ANIMAL 1 FBW 1 BRAIN 1 ADRENAL GLANDS | HEART 1 KIDNEYS 1 1 (Gms) 1(Gms) %FBW j (Gms) %FBW %BRAIN | (Gms ) %FBW %BRAIN j (Gms) %FBW %BRAIN 1 (Gms) LIVER 1 %FBW %BRAIN 1 648346 648389 648394 648404 648425 648426 648427 648434 648442 Mean S.D. 1307.00 281.20 308.10 313.60 406.30 453.50 j350.70 347.90 442.70 1 1356.78 162.978 1 2.001 1 1.997 1 1.953 I 1.923 1 1.966 1 2.027 1 2.107 1 1.833 1 2.046 1 1 1.984 1 0.078 0.6518 0.7102 0.6339 0.6132 0.4839 0.4470 0.6008 0.5269 0.4622 0.5700 0.0931 1 j j i i j j 1 \ 1 0.073 0.0238 3.6482 1 0.090 0.0320 4.5068 j 0.053 0.0172 2.7138 j 0.061 0.0195 3.1721 j 0.062 0.0153 3.1536 j 0.067 0.0148 3.3054 1 0.066 0.0188 3.1324 j 0.044 0.0126 2.4004 j 0.062 0.0140 3.0303 j 0.064 0.0187 3.2292 1 0.013 0.0060 0.5941 1 1.278 0.4163 63.868 1.035 0.3681 51.828 1.136 0.3687 58.167 1.126 0.3591 58.554 1.406 0.3460 71.516 1.345 0.2966 66.354 1.171 0.3339 55.577 1.179 0.3389 64.321 1.309 0.2957 63.978 1.221 0.3470 61.574 0.120 0.0375 6.0411 2.311 2.007 2.096 2.158 2.871 2.740 2.336 2.298 2.586 2.378 0.295 0.7528 115.49 0.7137 100.50 0.6803 107.32 0.6881 112.22 0.7066 146.03 0.6042 135.18 0.6661 110.87 0.6605 125.37 0.5841 126.39 0.6729 119.93 0.0528 14.503 1 8.817 2.8720 440.63 1 7.730 2.7489 387.08 1 8.315 2.6988 425.76 1 7.884 2.5140 409.98 1 12.130 2.9855 616.99 1 11.632 2.5649 573.85 1 8.459 2.4120 401.47 1 8.918 2.5634 486.52 1 12.161 2.7470 594.38 1 9.561 2.6785 481.85 1 1.856 0.1823 90.045 ! 1 1 1 I 1 1 1 1 11 1 1 Group : X - 300 mg/kg/day Treatment : 300 mg/kg/day X Sex :FEMALES ANIMAL 1 FBW BRAIN \ (Gms) (Gms) %FBW ADRENAL GLANDS | (Gms) %FBW %BRAIN | (Gms) HEART KIDNEYS %FBW %BRAIN j (Gms) %FBW %BRAIN 648350 648355 648359 648378 648383 648387 648398 648399 648419 1358.20 1284.90 1369.50 1322.60 276.40 323.80 323.40 352.70 1314.80 2.060 0.5751 1.907 0.6694 2.068 0.5597 1.907 0.5911 1.853 0.6704 1.876 0.5794 1.887 0.5835 1.864 0.5285 2.016 0.6404 0.064 0.0179 3.1068 1 1.282 0.3579 62.233 1 2.637 0.7362 128.01 0.058 0.0204 3.0414 i 1.049 0.3682 55.008 2.188 0.7680 114.74 0.100 0.0271 4.8356 j 1.397 0.3781 67.553 2.894 0.7832 139.94 0.050 0.0155 2.6219 j 1.160 0.3596 60.829 2.315 0.7176 121.39 0.055 0.0199 2.9682 j 1.084 0.3922 58.500 1.833 0.6632 98.921 0.056 0.0173 2.9851 j 1.140 0.3521 60.768 2.156 0.6658 114.93 0.049 0.0152 2.5967 1 1.394 0.4310 73.874 2.288 0.7075 121.25 0.059 0.0167 3.1652 1 1.067 0.3025 57.242 2.189 0.6206 117.44 0.050 0.0159 2.4802 1 1.171 0.3720 58.085 2.206 0.7008 109.42 (Gms) LIVER 1 %FBW %BRAIN 1 9.731 8.690 11.566 8.325 7.760 8.500 10.076 9.840 8.721 2.7166 3.0502 3.1302 2.5806 2.8075 2.6251 3.1156 2.7899 2.7703 472.38 455.69 559.28 436.55 418.78 453.09 533.97 527.90 432.59 1 j \ j i 1 j j FBW - Final Body Weight 796 Company Sanitized. Does not contain TSCA CBl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Organ Weight Listing (One-Month Recovery) Group : X - 300 :mg/kg/day Treatment : 300 mg/kg/day X Sex :FEMALES 1 ANIMAL 1 FBW 1 BRAIN 1 ADRENAL GLANDS 1 1 1 (Gms) i(Gms) %FBW 1 (Gms) %FBW %BRAIN 1 (Gms) HEART 1 KIDNEYS 1 %FBW %BRAIN 1 (Gms) %FBW %BRAIN 1 (Gms) LIVER 1 %FBW %BRAIN 1 1 1 Mean 1 S.D. 11 1 1 1 1 |325.14 1 1.938 0.5997 | 0.060 0.0184 3.0890 1 1.194 0.3682 61.566 1 2.301 0.7070 118.45 1 9.245 2.8429 476.69 1 31.491 I 0.086 0.0494 | 0.016 0.0037 0.6996 1 0.134 0.0343 5.8328 1 0.304 0.0520 11.510 i 1.165 0.2066 50.807 1 FEW - Final Body Weight 797 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Organ Weight Listing (One-Month Recovery) DuPont-6554 Group : II - 0 itig/kg/day Treatment : 0 mg/kg/day II Sex :FEMALES 1 ANIMAL 1 OVARIES 1 SPLEEN 1 THYMUS 1 THYROID GLAND 1 UTERUS 1 1 1(Gms) %FBW %BRAIN j(Gins) %FBW %BRAIN 1(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN | 1 648346 1 0.108 0.0352 5.3973 1 0.598 0.1948 29.885 1 0.228 0.0743 11.394 1 0.019 0.0062 0.9495 1 0.721 0.2349 36.032 1 j 648389 j 0.146 0.0519 7.3110 j 0.512 0.1821 25.638 j 0.275 0.0978 13.771 j 0.015 0.0053 0.7511 j 0.585 0.2080 29.294 j I 648394 j 0.122 0.0396 6.2468 j 0.483 0.1568 24.731 j 0.287 0.0932 14.695 j 0.015 0.0049 0.7680 j 0.533 0.1730 27.291 j 648404 j 0.126 0.0402 6.5523 j 0.476 0.1518 24.753 j 0.333 0.1062 17.317 1 0.018 0.0057 0.9360 j 0.965 0.3077 50.182 I 1 648425 0.123 0.0303 6.2564 j 0.547 0.1346 27.823 j 0.436 0.1073 22.177 j 0.020 0.0049 1.0173 j 0.628 0.1546 31.943 1 j 648426 j 0.166 0.0366 8.1894 j 0.625 0.1378 30.834 j 0.362 0.0798 17.859 1 0.018 0.0040 0.8880 j 0.497 0.1096 24.519 1 1 648427 j 0.108 0.0308 5.1258 j 0.503 0.1434 23.873 j 0.371 0.1058 17.608 j 0.019 0.0054 0.9018 j 1.106 0.3154 52.492 1 I 648434 1 0.119 0.0342 6.4921 j 0.442 0.1270 24.113 j 0.241 0.0693 13.148 j 0.018 0.0052 0.9820 j 0.474 0.1362 25.859 j i 648442 j 0.092 0.0208 4.4966 j 0.593 0.1340 28.983 j 0.354 0.0800 17.302 j 0.021 0.0047 1.0264 j 0.987 0.2230 48.240 j 1 1 1 I 1 i I1 1 Mean | 0.123 0.0355 6.2297 1 0.531 0.1514 26.737 1 0.321 0.0904 16.141 1 0.018 0.0052 0.9134 1 0.722 0.2069 36.206 1 1 S.D. j 0.022 0.0085 1.1235 j 0.063 0.0231 2.6733 j 0.068 0.0148 3.2300 j 0.002 0.0006 0.0989 j 0.238 0.0719 11.149 j Group : X - 300 mg/kg/day Treatment : 300 mg/kg/day X Sex :FEMALES 1 ANIMAL 1 OVARIES 1 SPLEEN 1 THYMUS 1 THYROID GLAND 1 UTERUS 1 1 1(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN | 648350 1 648355 1 648359 1 648378 1 648383 1 648387 1 648398 [ 648399 1 648419 1 0.139 0.091 0.119 0.122 0.128 0.092 0.129 0.111 0.127 0.0388 0.0319 0.0322 0.0378 0.0463 0.0284 0.0399 0.0315 0.0403 6.7476 4.7719 5.7544 6.3975 6.9077 4.9041 6.8362 5.9549 6.2996 1 j j j 1 j j j j 0.550 0.543 0.539 0.535 0.586 0.477 0.693 0.491 0.459 0.1535 26.699 0.1906 28.474 0.1459 26.064 0.1658 28.055 0.2120 31.624 0.1473 25.426 0.2143 36.725 0.1392 26.341 0.1458 22.768 1 j j j 1 j j j j 0.252 0.0704 12.233 | 0.187 0.0656 9.8060 j 0.272 0.0736 13.153 | 0.298 0.0924 15.627 | 0.293 0.1060 15.812 I 0.280 0.0865 14.925 | 0.391 0.1209 20.721 j 0.415 0.1177 22.264 j 0.382 0.1213 18.948 j 0.020 0.0056 0.9709 0.022 0.0077 1.1536 0.028 0.0076 1.3540 0.026 0.0081 1.3634 0.015 0.0054 0.8095 0.018 0.0056 0.9595 0.023 0.0071 1.2189 0.016 0.0045 0.8584 0.020 0.0064 0.9921 | | | | | | | | | 0.513 0.1432 24.903 | 0.750 0.2633 39.329 | 0.830 0.2246 40.135 | 0.697 0.2161 36.550 | 0.638 0.2308 34.431 | 0.466 0.1439 24.840 | 1.382 0.4273 73.238 | 0.491 0.1392 26.341 j 0.535 0.1699 26.538 | FBW - Final Body Weight 798 Company Sanitized. Does not contain TSCA G il ) H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats___________________________ ) ) DuPont-6554 Organ Weight Listing (One-Monthi Recovery) Group : X - 300 mg/kg/day Treatment : 300 mg/kg/day X Sex :FEMALES | ANIMAL | OVARIES | SPLEEN | THYMUS | THYROID GLAND 1 TERUS 1 1 |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN | 1 | Mean | S.D. 1 1 !' 1 1 ! | 0.118 0.0364 6.0638 | 0.541 0.1683 28.020 | 0.308 0.0949 15.943 1 0.021 0.0064 1.0756 | 0.700 0.2176 36.256 1 | 0.017 0.0057 0.7957 | 0.069 0.0297 4.0570 | 0.074 0.0224 4.0648 | 0.004 0.0012 0.2050 | 0.285 0.0906 15.197 j FBW - Final Body Weight 799 Coitypany Sanitized. Does not contain TSC CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Organ Weight Listing (Three-Month Recovery) Group : II - 0 mg/kg/day Treatment : 0 mg/kg/day II Sex :FEMALES ANIMAL | FBW 1 KIDNEYS | (Gms) 1{Gms) %FBW 648356 648357 648405 648422 648431 Mean S.D. |296.10 1 332.90 1 272.30 1 351.60 1 |332.20 1 1I ]317.02 ! |32.078 i 2.578 0.8707 2.380 0.7149 2.323 0.8531 2.136 0.6075 2.128 0.6406 2.309 0.7374 0.187 0.1203 1 LIVER |(Gms) %FBW | 8.575 2.8960 i 10.311 3.0973 j 8.361 3.0705 j 7.879 2.2409 j 8.443 2.5415 1 | 8.714 2.7693 j 0.931 0.3693 | THYROID GLAND \ (Gms) %FBW | 0.013 0.0044 j 0.015 0.0045 | 0.013 0.0048 j 0.013 0.0037 j 0.023 0.0069 1 j 0.015 0.0049 | 0.004 0.0012 Group : VI - 10 mg/kg/day Treatment : 10 mg/kg/day VI Sex :FEMALES ANIMAL | FBW 1 KIDNEYS 1 (Gms) 1(Gms) %FBW 648365 648384 648385 648413 Mean S.D. |375.30 1 i340.00 1 340.30 1 371.30 1 11 (356.73 1 |19.209 1 2.120 0.5649 2.229 0.6556 2.285 0.6715 3.062 0.8247 2.424 0.6792 0.431 0.1078 1 |(Gms) LIVER %FBW | 9.032 2.4066 | 8.793 2.5862 | 9.846 2.8933 j 11.272 3.0358 I 1 9.736 2.7305 j 1.119 0.2860 | THYROID GLAND |(Gms) %FBW | 0.015 0.0040 | 0.018 0.0053 | 0.021 0.0062 I 0.023 0.0062 1 | 0.019 0.0054 j 0.004 0.0010 DuPont-6554 FBW - Final Body Weight 800 Company Sanitized. D oes not contain TSGA CBt H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Organ Weight Listing (Three-Month Recovery) Group : VIII - 60 mg/kg/day Treatment : 60 mg/kg/day VIII Sex :FEMALES | ANIMAL | FBW 1 KIDNEYS i j (Gms) 1(Gms) %FBW | 648349 |338.40 j | 648360 331.90 1 i 648379 411.10 1 1 648386 342.70 1 | 648415 372.90 11 |{ | Mean | S.D. |359.40 1 ]32.906 1 2.324 0.6868 1.909 0.5752 2.874 0.6991 2.286 0.6671 2.778 0.7450 2.434 0.6746 0.394 0.0625 1 |(Gms) LIVER %FBW | 8.878 2.6235 \ 7.928 2.3887 j 11.153 2.7130 j 7.937 2.3160 | 11.252 3.0174 1 | 9.430 2.6117 | 1.664 0.2794 I THYROID GLAND |(Gms) %FBW | 0.015 0.0044 \ 0.016 0.0048 j 0.019 0.0046 j 0.013 0.0038 j 0.020 0.0054 1 j 0.017 0-0046 | 0.003 0.0006 Group : X - 300 mg/kg/day Treatment : 300 mg/kg/day X Sex :FEMALES | ANIMAL | FBW 1 KIDNEYS 1 j (Gms) 1(Gms) %FBW 1 |(Gms) LIVER %FBW ! THYROID GLAND |(Gms) %FBW | 648358 1310.60 1 2.041 0.6571 1 648367 |410.60 I 2.663 0.6486 | 648373 \ 362.70 1 2.286 0.6303 | 648391 |364.20 1 2.726 0.7485 j 648411 |319.90 2.517 0.7868 11 11 | Mean 353.60 1 2.447 0.6942 j S.D. j40.090 1 0.283 0.0690 | 7.908 2.5460 | 13.339 3.2487 9.386 2.5878 | 11.755 3.2276 | 9.692 3.0297 I j 10.416 2.9280 | 2.134 0.3408 | 0.015 0.0048 \ 0.027 0.0066 \ 0.017 0.0047 | 0.022 0.0060 | 0.021 0.0066 1 j 0.020 0.0057 | 0.005 0.0009 I | | j \ j j 1 | | ! | | j j | j I | | FBW - Final Body Weight 801 DuPont-6554 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 APPENDIX N INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS 802 Company Sanitized. D oes not contain TSCA CB1 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648216 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : LIVER 803 Company Sanitized. Does not contain TSCA CBS H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648219 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. THYROID GLAND : ALTERATION, COLLOID, minimal. 804 Company Sanatizea. Does n o i contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648220 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 805 Company Sanitized. Does noi contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648222 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No Microscopic Abnormality Observed : THYROID GLAND 806 Company Sanitized. Does not contala TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648225 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 648225 Continued on the next page .... 807 Company Sanitized. Does not contain TSCA CSI An t % / H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats__________________________________________________________ DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648225 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 808 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648226 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 809 Company Sanitized. Dees not contain TSCA CBf /**""*K\ H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648228 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 810 Company Sanitized. Does not contain TSCA CBS H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648233 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYDRONEPHROSIS, UNILATERAL, minimal. No Microscopic Abnormality Observed : THYROID GLAND 811 Company Sanitized. Does not contain TSCA C8I H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648238 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. EYE{S ) WITH OPTIC NERVE : ATROPHY, RETINAL, minimal. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 648238 Continued on the next page .... 812 Company Sanitized. Does not contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648238 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 813 Company Sanitized. Does sot contai TSC CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648246 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, 648246 Continued on the next page -- .Company Sanitized. Does not contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648246 Continued from previous page Histopathology : No Microscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 815 Company Sanitized. Does of contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Hales Animal Ref Microscopic & Macroscopic Findings 648247 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S } WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, mild. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, 648247 Continued on the next page .... 816 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648247 Continued from previous page Histopathology : No Microscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 817 Company Sanitized. Boss noi confai TSCA CBf H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648250 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. 818 Compatif Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648255 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 648255 Continued on the next page ... . 819 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648255 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 820 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648256 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PANCREAS : ATROPHY, minimal. PARATHYROID GLANDS : NOT PRESENT. 648256 Continued on the next page .... 821 Company Sanitized. D o b s not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648256 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 822 Company Sanitized. Does not contain TSCA CBi (^***S, H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats__________________________________________________________ DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648257 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. 823 Company Sanitized. Does not contain TSGA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648260 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : LIVER : HERNIA, INVOLVING DIAPHRAGM. No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 824 Conpany Sanitized. Does not contain TSC CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648264 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE f 0 m 'N Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND 825 Company Sanitized Does no! contain TSCA CEU H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648271 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND 826 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648278 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No Microscopic Abnormality Observed : THYROID GLAND 827 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648294 Accidentally Killed Duration of dosing-days: 38 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 828 Company Sanitized. Does not contain TSCA CSI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648297 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : LIVER 829 Company Sanitized. Doss not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648298 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : TESTES : DISCOLORATION, OPAQUE, LEFT. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE H istopathology LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 830 Cwnpauy Sanitized. Does not contain TSCA CBt H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648307 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PHARYNX/LARYNX : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 648307 Continued on the next page .. .. 831 C om paq Sanitized. TSCA ^ H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648307 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 832 Company Sanitized. Does not contain TSCA C M H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648311 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS 833 Company Sanitized. D not main TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648315 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. EYE(S) WITH OPTIC NERVE : FOLD/ROSETTE, RETINAL, minimal. NOSE : ODONTODYSPLASIA, minimal. 648315 Continued on the next page ... H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648315 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 835 Company Sanitized. Does not contain TSC CEB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : III - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day III Sex: Males Animal Ref Microscopic & Macroscopic Findings 648227 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. No Microscopic Abnormality Observed : KIDNEYS 836 Ccwtpanif Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : III 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day III Sex: Males Animal Ref Microscopic & Macroscopic Findings 648232 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : POPLITEAL LYMPH NODE : MASS, LEFT, 6X4X3 CM DIA. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. POPLITEAL LYMPH NODE : HEMANGIOSARCOMA [M]. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND [B]=BENIGN, [M]=MALIGNANT 837 Company Smithed. Sees noi contain TSCA CBf H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : III 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day III Sex: Males Animal Ref Microscopic & Macroscopic Findings 648252 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND 838 Company S a n itized . Does noi contain TSCA CBf H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : III - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day III Sex: Males Animal Ref Microscopic & Macroscopic Findings 648258 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS 839 Company Sanitized, Does noi contain TSCA C8t H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : III 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day III Sex: Males Animal Ref Microscopic & Macroscopic Findings 648269 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 840 Company Sanitized. Doss not contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : III 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day III Sex: Males Animal Ref Microscopic & Macroscopic Findings 648274 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS 841 Company Sanitized. Does not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : III - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day III Sex: Males Animal Ref Microscopic & Macroscopic Findings 648290 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS 842 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : III 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day III Sex: Males Animal Ref Microscopic & Macroscopic Findings 648299 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS 843 Company Sanitized. Does not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : III - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day III Sex: Hales Animal Ref Microscopic & Macroscopic Findings 648302 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. /****% . 844 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : III 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day III Sex: Males Animal Ref Microscopic & Macroscopic Findings 648303 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : KIDNEYS 845 Company Sanitized. Does not contain TSCA CBf H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : V 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648221 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : HYDRONEPHROSIS, UNILATERAL, mild. No Microscopic Abnormality Observed : THYROID GLAND 846 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats A Individual Animal Listing Showing animal data for individual animals DuPont-6554 Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648224 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS 847 Company Saniteed. Does not contain TSCA CE(j[ H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648245 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS 848 Company Sanitized!. Dees not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648253 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 849 Company Sanitized. Does not contain SC CBS H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648254 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA, BILE DUCT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 850 Company Sanitized. Does not contain TSC CBS H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648265 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 851 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648273 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 852 Company Sanitized. Does not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648283 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 853 Company Sanitized, Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648286 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS 854 Company Sanitized. Does not contain TSCA CEI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : V 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648288 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA, BILE DUCT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. Company Sanitized. Does not contain T3CA CM H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648301 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No Microscopic Abnormality Observed : THYROID GLAND 856 Company Sanitized. Coes not contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : V 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648309 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS 857 Company Sanitized. Does not contain TSCA CBI /*a****\ H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648310 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : KIDNEYS : DISCOLORATION, MOTTLED, BILATERAL. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : LIVER 858 Company Sanitized. Does not contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648312 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 859 Company Sanitized, uoes not smimm TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648313 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS 860 Company Sanitized. Does not contain TSCA GBl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648223 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, mild. KIDNEYS : CYST, minimal. No Microscopic Abnormality Observed : THYROID GLAND 861 Company Sanitized. Does not contain TSC CB1 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648237 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, mild. FATTY CHANGE, MEDIAN CLEFT, mild. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND 862 Company Sanitized. Does not contain TSCA CB1 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648243 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND 863 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic Sc Macroscopic Findings 648244 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal.. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. 864 Company Sanitized. Does not contain TSCA C8I H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648259 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No Microscopic Abnormality Observed : THYROID GLAND 865 Company Sanitized. Does not contain TSCA Cfll H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648266 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : Mo Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. NECROSIS, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS 866 Company Sanitised, Does not contain TSCA CK H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648268 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 867 Company Sanitized. Does of contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648270 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 868 Company Sanitized, Does not contain TSCA CM H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648279 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA, BILE DUCT, minimal. NECROSIS, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 869 Company Sanitized. Does not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648280 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : KIDNEYS 870 cosjiifif SatisfedL lies m i & m M a S G cm H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648285 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 871 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648296 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. 872 Company Sanitized, Does riot contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648300 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No Microscopic Abnormality Observed : THYROID GLAND 873 ampm* coniata T8CA C H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648305 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS 874 Company Sanitized. Does not contain TSC CBS H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats__________________________________________________________ DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648314 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : LIVER : DISCOLORATION, PALE. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, BILATERAL. No Macroscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : FIBROSIS, BILE DUCT, moderate. ECTASIA, BILE DUCT, severe. INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 875 Company Sanitized. Does not contain TSCA G8f H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648217 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S} WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 648217 Continued on the next page .... 876 Corapmf Oon Mmajn tsca H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648217 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 877 Company Sanitized, Does not contain TSCA C ft H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648218 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. PARATHYROID GLANDS : NOT PRESENT. 648218 Continued on the next page 878 Company Sanitized. Does not contain TSCA CfM H-24678: Subchionic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648218 Continued from previous page Histopathology : NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 879 Company Sanitized. Does not contain TSC CB1 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648230 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : HYDRONEPHROSIS, UNILATERAL, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. 880 Company Sanitized. Does not contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648231 Found Dead Duration of dosing-days: 57 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : LUNGS : FLUID, CLEAR, DIFFUSE. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, minimal. LUNGS : EDEMA, minimal. FOREIGN MATERIAL, mild. HEART : CARDIOMYOPATHY, minimal. 648231 Continued on the next page .... 881 Company Sanitized. Does noi contain TSCA CBf H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648231 Continued from previous page Histopathology : THYROID GLAND : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, minimal. PARATHYROID GLANDS : NOT PRESENT. NOSE : FOREIGN MATERIAL, mild. No Microscopic Abnormality Observed : SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 882 Company Sanitized. Does not contain TSCA CBf H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648234 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. THYROID GLAND : ALTERATION, COLLOID, minimal. 883 Company Sanitized. Does no! contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648235 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 648235 LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. TESTES : DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, BILATERAL, minimal. Continued on the next page .... 884 Compaq san,'te d . D o * contain TSCAOM H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic Sc Macroscopic Findings 648235 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 885 Company Sanitized. Does oof contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648236 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. 648236 Continued on the next page .... 886 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648236 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 887 Company Sanitized. Does not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648239 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : -:o LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, moderate. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal.. HYPERTROPHY, TUBULAR, minimal. PANCREAS : ATROPHY, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, mild. 648239 Continued on the next page .... 888 Company Sanitized. Does not contain TSCA CEB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648239 Continued from previous page Histopathology : ESOPHAGUS : NOT PRESENT. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 889 Company Sanitized. Does not contain TSC CHI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648240 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. 890 Company Sanitized, Does not contain TSCA CBS H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648241 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. No Microscopic Abnormality Observed : KIDNEYS 891 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648248 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA, FOCAL, ACINAR CELL, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. 648248 Continued on the next page .... 892 Company Sanitized. Does not contain TSCA CB1 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648248 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE Company Sanitized. Does not contain TSC CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648249 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, minimal. HYPERTROPHY, FOLLICULAR, minimal. 894 Company Sanitized. Does not contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648261 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : KIDNEYS 895 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648262 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. 896 Company Santtbed. Does not eontaits TSCA C8! / '""N H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648272 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. 897 Company Sanitized, Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648275 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERPLASIA, BILE DUCT, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. PANCREAS : ALTERATION, BASOPHILIC, FOCAL, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, mild. 648275 Continued on the next page .... 898 Company Sanitized. D e s not contain TSCA CM H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648275 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 899 Company Sanitized, Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648277 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : KIDNEYS 900 C0 panfSaiilfi2e 0es not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648282 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 901 Company Sanitized. Does not contain TSCA GB! H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex : Males Animal Ref Microscopic & Macroscopic Findings 648284 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal., THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. 902 Company Sanitized. Does rmtcmlaln r s m CE* H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648287 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. 903 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648289 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, moderate. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. 648289 Continued on the next page .... 904 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648289 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 905 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648292 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, moderate. THYROID GLAND : ALTERATION, COLLOID, minimal. /'"""N 906 Company Sanitized. Uo*s not eontua 1SCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group :: IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648293 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. FATTY CHANGE, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal." HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 648293 Continued on the next page .... 907 Con*-* sam..xi, Don. no-- 1SCACB1 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648293 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 908 Company Sanitized. Does not contain TSC CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648306 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : /) LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : KIDNEYS 909 Company Sanitized. Does not contain TSCA CBl /"""N H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648308 Terminal Sacrifice Killed on Day : 92 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. 648308 Continued on the next page .... 910 Company SaniiaesL Does oat contain TSCA CSl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648308 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 911 Company Sanitized. Doss not contala TSCA C B t H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648346 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 912 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648351 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PHARYNX/LARYNX : INFLAMMATION, SUBACUTE/CHRONIC, minimal. MAMMARY GLAND (FEMALE) : NOT PRESENT. 648351 Continued on the next page .... 913 Company Sanitized. Does not contain TSCA C8I H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648351 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, EYE(S ) WITH OPTIC NERVE, SKIN, OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 914 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648353 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. PARATHYROID GLANDS : NOT PRESENT. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 648353 Continued on the next page .... 915 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex; Females Animal Ref Microscopic & Macroscopic Findings 648353 Continued from previous page Histopathology : No Microscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 916 Company Sanitized. Does not contain TSCA CB //*s**\ H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648356 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : Ho Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 917 Company Sanitized. Does not contain TSCA CBf H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648357 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 918 Company Sanitized. Does not contain TSC G!Pi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648370 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. UTERUS : DILATATION, GLAND/LUMEN, mild. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 648370 Continued on the next page .... 919 Company Sanitized. Does not contain TSCACBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648370 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 920 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_____________________________________________________ DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648372 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. UTERUS : DILATATION, GLAND/LUMEN, mild. 648372 Continued on the next page 921 Company Sanitized. L>oesnot coniami TSC CBt H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648372 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 922 Company Sanitized, Does not contain TSCA CM /*jr"-\ H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648389 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 923 Company Sanitized. Does not contain TSCA C8J H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648393 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : NOT PRESENT. MAMMARY GLAND (FEMALE) : NOT PRESENT. UTERUS : DILATATION, GLAND/LUMEN, minimal. 648393 Continued on the next page .... 924 Company Sanitized. Does not contain TSCA Cfil H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648393 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 925 Company Sanitized, u oes m i contain TSCA CBf H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648394 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 926 Company Sanitized. Does not contain Tsc4 cm H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648395 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PANCREAS : ATROPHY, minimal. 648395 Continued on the next page .... 927 Company Sanitiased. Dees i contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648395 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 928 Company Sanitized. Does not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648404 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 929 Company Saniteed. Horn not contain TSCA CSi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group :; II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648405 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 930 Company Sanitized. Does not contain TSCA CSl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648421 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal.. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCREAS : DEGENERATION/NECROSIS, ACINAR CELL, minimal. HYPERPLASIA, FOCAL, ACINAR CELL, minimal. 648421 Continued on the next page .... 931 Company Sanitized, Does not contain TSCA c s i H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648421 Continued from previous page Histopathology : No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 932 catCompany Sanitized. Does not contain tsca H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648422 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 933 Company Sanitized, Does not contain TSCA C1I H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648423 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. UTERUS : DILATATION, GLAND/LUMEN, mild. 648423 Continued on the next page .... 934 Company Sanitized. Does not contain TSCA CBf H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648423 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 935 Company Sanitized. Does not contain TSC CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648425 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 936 Company Sanitized. Does not contalo TSCA CSS H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group :: II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic Sc Macroscopic Findings 648426 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 937 Company Sanitized. Does not contain 1SCA CB1 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648427 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 938 Company Sanitized, O ses not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648430 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. INFARCT, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, 648430 Continued on the next page .... 939 Company Sanitized. S e e s not contain TSCA CBl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648430 Continued from previous page Histopathology : No Microscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 940 Company Sanitized. Does not contain T3CA CBl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648431 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE (S ) WITH OPTIC NERVE, SKIN,.. MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 941 Company Sanitized. Does not contain TSC CB1 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648434 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 942 Company Sanitized, Does not contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648436 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. PANCREAS : ATROPHY, minimal. ADRENAL GLANDS : NOT PRESENT, MEDULLA. THYROID GLAND : ALTERATION, COLLOID, minimal. ESOPHAGUS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 648436 Continued on the next page .... 943 Company Sanitized. Dees not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648436 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 944 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648439 Accidentally Killed Duration of dosing-days: 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : EYE(S ) WITH OPTIC NERVE : DISCOLORATION, WHITE, LEFT. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : FATTY CHANGE, MEDIAN CLEFT, mild. JEJUNUM : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, moderate. ILEUM : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, mild. PARATHYROID GLANDS : NOT PRESENT. 648439 Continued on the next page 945 Company Sanitized. Does not contain TSCA CBt /"'-v H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648439 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 946 Company Sanitized, Does nt contain TSCA ml H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648442 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 947 Company Sanitized. Does not contain TSCA CSI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IV - 60 mg/kg(Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648364 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 948 Company Sanitized. Does no! contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648369 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND /-N 949 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648390 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 950 Sanitized. Does not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648396 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 951 C om pauj Sanitized. Does not contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group ;: IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648397 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 952 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IV 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648402 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 953 Company Sanitized Does not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648408 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Higtopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 954 Company Sanitized. Does not contain TSCA CBt H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group :: IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648409 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : KIDNEYS : CYST, RIGHT, 2MM DIA. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 955 Company Sanitized. Does not contain T5CA CBS H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648410 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 956 noicontainTSCACBl Company Sanitized Does H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group ;: IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648424 Terminal Sacrifice Killed on Day : 93 Exposure Group : 9 0 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 957 Company Sanitized. Does not contain TSCA CB1 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648345 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 958 Company Sanitized. Poes not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648352 Unscheduled Sacrifice Duration of dosing-days: 161 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : SKIN : MASS, PINK, FIRM, INGUEN, RIGHT, 8CM DIA. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. MAMMARY GLAND (FEMALE) : FIBROADENOMA [B]. [B]=BENIGN, [M]=MALIGNANT 959 Company Sanitized. Dosa not contalo TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648365 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 960 Company Sanitized, Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic &. Macroscopic Findings 648366 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 961 Company Sanitized, Does not contain TSCA CBl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648374 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 962 Company Sanitized. Does not contain TSC CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group :: VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648382 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 963 Company Sanitized. Does not contain TSCA CBI /"""N H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648384 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, "COLLOID, mild. 964 Company Sanitized. Does not contain TSCA C8I H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648385 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 965 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648403 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 966 Company Sanitized. Does si contain TSCA CBf H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648406 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 967 Company Sanitized Does not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats___________________________________________________________ DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648413 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : KIDNEYS : DILATATION, LEFT. URINARY BLADDER : CALCULUS\CALCULI. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648414 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 969 Company Sanitized Does not contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648429 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 970 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648433 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 971 Company Sanitized. Boss riot contain ISCA CBI /'"N H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group :; VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648441 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 972 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648348 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 973 Company Sanitized. Does not contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648349 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 974 Company Sanitized. Does not contain TSCA CBS H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648354 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 975 Company Sanitized, Does not contain TSC CSl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648360 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, mild. 976 Company Sanitized. Does not contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648362 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : LIVER : HERNIA, INVOLVINS DIAPHRAGM. No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 977 Company Sanitized. Boss not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group :: VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648368 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 978 Company Sanitized. Does not contain TSCA CB1 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group :: VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648379 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 979 Company Sanitized. Does not contain TSCA CESI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648380 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND /^***K. 980 Company Sanitized. Does not contain TSCA CSl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648381 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 981 Company Sanitized. Does not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group :: VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648386 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 982 Company Sanitized. Does not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648401 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 983 Company Sanitized. Does noi contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648415 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. 984 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VIII 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648417 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 985 Company Sanitized, Does noi contain TSCA CBI H-24678: Subchronic Toxicity 90-Pay Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648432 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 986 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group ;: VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648440 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. [^ W***N. 987 Company Sanitized. Does not contain TSCA CS1 H-24678: Subchionic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648347 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : PANCREAS : ATROPHY, minimal. HYPERPLASIA, FOCAL, ACINAR CELL, mild. PITUITARY GLAND : CYST, minimal. No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, PARATHYROID GLANDS, 648347 Continued on the next page .... 988 Company Sanitized Does not contain TSCA CB H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic Sc Macroscopic Findings 648347 Continued from previous page Histopathology : No Microscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 989 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats _____________________ DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648350 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 990 Company Sanitized, Does rio! contain TSCA GBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648355 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 991 Company Sanitized. Doss not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648358 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 992 Company Sanitized. Does not contain TSCA H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648359 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 993 Company Sanitized. Boes not contain TSCAC8I H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648363 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, 648363 Continued on the next page .... 994 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group ;: X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648363 Continued from previous page Histopathology No Microscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 995 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648367 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 996 Company Sanitized. Does not conia TSC C8 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648373 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 997 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648375 Found Dead Duration of dosing-days: 5 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : LIVER : DISCOLORATION, DARK, RAISED, LEFT, MIDDLE, FEW, < 3MM DIA EACH. No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, minimal. KIDNEYS : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, mild. DUODENUM : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, mild. JEJUNUM : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, mild. 648375 Continued on the next page .... 998 Company Sanitised, Does not contain TSCACBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648375 Continued from previous page Histopathology : ILEUM : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, moderate. THYROID GLAND : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, moderate. PARATHYROID GLANDS : NOT PRESENT. ESOPHAGUS : INFLAMMATION, SUBACUTE/CHRONIC, mild. PHARYNX/LARYNX : NOT PRESENT. EYE(S ) WITH OPTIC NERVE : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, severe. BONE MARROW : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, mild. NOSE : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, mild. No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 999 Company Sanitized. Does not contain TSCA CBl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648376 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : LIVER, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, 648376 Continued on the next page .... 1000 Company Sanitized. Does not contain TSCA C8 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648376 Continued from previous page Histopathology : No Microscopic Abnormality Observed : ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 1001 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648378 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 1002 Company Sanitized. Does not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648383 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 1003 ,,,, * * * * D" s TSCA H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648387 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, mild. 1004 Company Sanitized. B oss not contain TSCA C8I H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648388 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. PARATHYROID GLANDS : NOT PRESENT. NOSE : REGENERATION, OLFACTORY, EPITHELIUM, minimal. 648388 Continued on the next page .... 1005 Company Sanitized. Does not contain TSCA CBS H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648388 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 1006 Company Sanitized. O ses not contain TSCft CBS H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648391 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 1007 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648392 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. UTERUS : DILATATION, GLAND/LUMEN, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 648392 Continued on the next page .... 1008 Company Sanitized. Does not contain TSCA CBi H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648392 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 1009 Company Sanitized. Does not contain TSCA CB! H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648398 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 1010 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648399 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 1011 Company Sanitized. Does not contain TSCA GBt H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648400 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCREAS : DEGENERATION/NECROSIS, ACINAR CELL, minimal. HYPERPLASIA, FOCAL, ACINAR CELL, minimal. . THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. 648400 Continued on the next page .... 1012 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648400 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 1013 Company Sanitized. Does not contain TSCA CE H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648407 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PARATHYROID GLANDS : NOT PRESENT. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, 648407 Continued on the next page .... 1014 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648407 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 1015 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648411 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. 1016 Company Sanitized. Coes not c o n ia TSCA C8 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648412 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : ESOPHAGUS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. UTERUS : DILATATION, GLAND/LUMEN, mild. No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 648412 Continued on the next page .... 1017 Company Sanitized. Does not contain TSCA CBl H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648412 Continued from previous page Histopathology : No Microscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 1018 Company Sanitized. Does not contain TSC CQf H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic &. Macroscopic Findings 648419 Terminal Sacrifice Killed on Day : 122 Exposure Group : 1 Month recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 1019 Company Sanitized. Doss not contain TSCA CBS H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648435 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PARATHYROID GLANDS : NOT PRESENT. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, 648435 Continued on the next page .... 1020 Company Sanitized. Does not contain TSCA CBI H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648435 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 1021 Company Sanitized. Does not contain TSCAC8 H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-6554 Individual Animal Listing Showing animal data for individual animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648438 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90 day Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE /-" * N 1022 Company Sanitized,, Does not contain TSCA CB1