Document 71NqrMqqjqQQ4neYvwm8ENnma
v Monsanto
Uonitnta Co*ny 900 N. liAtfM'tH S(. Luia. Uniaun 93199
(314: 814-1000
July 18, 1975
Dr. J.C. Calandra Industrial BIO-TEST Laboratories 1310 Frontage Rd. Northbrook, 111. 60062
re: AROCLOR 2-year Rat Feeding Studies
Dear Joe:
The attached table summarizes a comparison of the 3 revised AROCLOR reports (1242, 1254, 1250).
In 2 instances, the previous conclusion of "slightly tuaorigenic" was changed to "does not appear to be carcinogenic". The latter phrase is preferable. May we request that the AROCLOR 1254 report be amended to say "does net appear to be carcinogenic".
The number of hepatomas reported for AROCLORS 1260 and 1242 have been interchanged. This appears to have arisen from con fusion regarding the numbering of the animals. The original reports show tumors in animals with numbers in the 100-300 range for AROCLOR 1260 and in the 500 to 800 range for AROCLOR 1242. This leads me to conclude that the numbering scheme shown in the second set of reports is correct. With AROCLOR 1254 confusion is compounded. The original report showed tumors in animals with numbers in the units to teens, but the revised report shows animal numbers ranging from 40 to 1000. Can this be straightened out?
I was unable to reconcile the differences in the animal numbers between the first supplemental report and the original reports, I had inquired as to the changes in the numbers. As I recall, I was told that the sections had been renunoered when the new slides were made and that a key relating to the sets of numbers
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WATER PCB-00045799
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Dr. J.C. Calandra July 18, 1975 Page - 2 - .
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* would be supplied. This has not been done. It may not be necessary for AEOCLORS 1260 and 1242, but AEOGtOR 1254 remains unresolved.
Insofar as I can see, the remainder of the reports appear acceptable.
Kindest personal regards.
Sincerely,
George J. Levinskas, PhD Mgr., Environmental Assessment
and Toxicology
/bkp
att. cc: Dr. George Eoush, Jr., M.D.
WATER PCB-00045800
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Product
Supplemental Report #1 (mailed)
AROCLOR 1260
conclusion
slightly tuaorigenic
hepatomas
3
range of test animal nos:
p. 9
600 to -800
p. 10
1000 series
p. 11
70 to 100
p. 12
500 to 600
P. 13
600 to 700
p. 14
700 series
Supplemental Report #2 (JCC delivered
does not appear carcinogenic
7
100 to 300
8co to qoo
10 to 40
80 to 200
200 to 300 200 to 300
AROCLOR 125^ conclusion
hepatomas
slightly tumorigenic
.6
slightly tumorigenic
6
AROCLOR 1242
conclusion
slightly tumorigenic
does not appear carcinogenic
hepatomas
7
3
range of test animal nos.
as in report #2
as in report #1
for AROCLOR 1260
AROCLOR 1250
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WATER PCB-00045801