Document 6ybyz98EYE0wQGEmq1be9JKE

2-4. P t S. I? 7< t ' -.n.-'. as; E . J. du P o n t d e N e m o u r s & C o m p a n y IN C O N PO n ^ T E D W il m in g t o n , D e l a w a r e 19898 POLYMER PRODUCTS DEPARTMENT t X P t R I M L N T A L S i t i ION PERSONAL AND CONFIDENTIAL cc A. J . Dahl - 353 B. W. Karrh - Nil 400 L. J. Pa pa - 289 PPvAL FILE I.C. -AZllb-fStH- July 13, 1981 DR. R. J. MCCAFFREY PHOTO PRODUCTS ROCHESTER, N.Y. ANALYSIS OF BLOOD SAMPLES FOR PERFLUOROOCTANOATE (Job No. 311-681; PRAL Nos. 81-2233 to 2238; Notebook Nos. F22514,E26238) As requested in your letter of 5/12/81 to L. J. Papa, the 6 blood samples submitted then have been analyzed for perfluorooctanoate (Cg). Results and sample identification are given in the attached table. As noted there, the analyses were done using a gas chromatographic method specific for Cg (Lab Method Number ES-567) but resuLts have been reported as ppm F for comparison with total organic fluorine analyses. Precision is + 10% relative standard deviation over most of the concentration range, somewhat less at the lowest values. The lower limit for quantitation is 0.007 ppm F (0.01 pprr. perfluorooctanoic acid), with a detection limit of m 0.004 ppm which can be distinguished from the reagent background but not well quantitated. Please contact me (772-4440) or L. J. Papa (772-2745) if you have any questions regarding the analyses. General questions on blood sampling can be directed to J. W. Raines or L. F. Percival. Attachment jah Key Uords: Perfluorooctanoic Acid Perfluorooctanoate Blood Analysis GC S. S. Stafford There's o world ol Hungs we re doing something about 000094 EXP000026 EID713840 TABLE I CONCENTRATION OF PrSFLUOROOCTANnATE IN BI.OOD (a) S a m p l e __ PRAL No. ' Date Sample 81-2233 5/19/81 81-2234 5/19/81 81-2235 5/19/81 81-2236 5/19/81 81-2237 5/19/81 81-2238 5/19/81 GC_ An alvs is 6/5/81 6/5/81 6/5/81 6/5/81 6/5/81 6/5/8 L Ce]:.c JJ 0.060 n.d . 0.057 0.010 n.d. <.007 (a) Analysis as described in Lab Method ES-567 ("Determination of Perfluorooctanolc Acid in Blood, Gas Chromatographic Method", S. Stafford, 4/3/81), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration standard (b) Although the analysis is specifically for perfluorooctanoate (acid or salts), concentrations are given in ppm fluorine for comparison with the results of total organic fluorine analyses. (ppm F - 0.688 x ppm perfluorooctanoic acid) Estimated uncertainty is + 10a relative standard deviation. The lower limit for quantitation is 0.007 pgF/g. The detection limit is n, 0.004 UgF/g, but concentrations in that range cannot be well quantitated and are reported as < 0.007. None detected (n.d.) is reported for samples with [Cg] < 0.CCA ppm. which cannot be distinguished from reagent background. ^ *R E D A C T E D * 000095 EXP000027 EID713841