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E. CSTUi^ME0t802 1. d u P o n t d e N e m o u r s & C o m p a n y IN CO RPO RATED
W il m in g t o n , Dela w a r e 19898
POLYM ER PRODUCTS DEPARTMENT EXPERIM EN TA L STATION
PERSONAL AND CONFIDENTIAL
cc: A. J. Dahl
B . W. K a r r h
L. J. Papa Pral File I.C.
- 353
- N1U00
- 269
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May 19, 1981
DR. 0. INSLEE TEXTILE FIBERS SPRUANCE, RICHMOND
ANALYSIS OF BLOOD SAMPLES FOR PERFLUOROOCTANOATE (Job No. 811-601; PRAL Nos. 81-01672-01698; Notebook Nos. E22514,E26238)
As requested in your letter of 4/21/81 to L. J. Papa, the 27 blood samples submitted then have been analyzed for perfluorooctanoate (Cg). Results and sample identification are given in the attached table.
As noted there, the analyses were done using a gas chromatographic method specific for Cg (Lab Method Number ES-567) but results have been reported as ppm F for comparison with total organic fluorine analyses. Precision is +_ 107. relative standard deviation over most of the concentration range, somewhat less at the lowest values. The lower limit for quantitation is 0.007 ppm F (0.01 ppm periluorooctanoic acid), with a detection limit of 'v 0.004 ppm which can be distinguished from the reagent background but not well quantitated.
Please contact me (772-4440) or L. J. Papa (772-2745) if you have any questions regarding the analyses. General questions on blood sampling can be directed to J. W. Raines or L. F. Percival.
Attachment jah
Key Words: Perfluorooctanoic Acid Perfluorooctanoate Blood Analysis
GC
S. S. Stafford
T h e re 's a w o rld o l th in g s we re d o in g so m e th in g about
000072
EXP000013
EID713827
TABLE I CONCENTRATION OF PERFLUOROOCTANOATE IN BLOOD (a)
Sample PRAL No. 81-1672 81-1673 81-1674 81-1675 81-1676 81-1677 81-1678 81-1679 81-1680 81-1681 81-1682 81-1683 81-1684 81-1685 81-1686 81-1687 81-1688 81-1689 81-1690 81-1691 81-1692 81-1693 81-1694 81-1695 81-1696 81-1697 81-1698
Date Sampled
4/13/81 4/13/81 4/13/81 4/14/81 4/14/81 4/14/81 4/13/81 4/14/81 4/14/81 4/14/81 4/13/81 4/15/81 4/15/81 4/14/81 4/14/81 4/14/81 4/14/81 4/14/81 4/14/81 4/14/81 4/14/81 4/21/81 4/15/81 4/16/81 4/15/81 4/16/81 4/16/81
P.R.No.
1966 2394 1203 0277 0187 2653 Salary 0815 0868 2810 1552 1511 0186 22142750 3026 2707 0301 1256 1233 2843 2927 1509 0650 1427 2151 2723
Name
GC Analysis___________________ (b) Date Analyzed [Cr ], ug F/g blood
4/28/81
0.007
4/28/81
0.035
4/28/81
0.019
4/28/81
0.056
4/28/81
0.007
4/29/81
0.0098
4/29/81
n.d.
4/29/81-4/30/81 0.043
4/29/81
0.0098
4/29/81
0.011
4/30/81
0.062
4/30/81
0.025
4/30/81 4/30/81
0.017 0.070
4/30/81 5/1/81
0.009 0.007
5/1/81
0.025
5/1/81 5/5/81 5/1/81 5/1/81 5/4/81 5/4/81
0.054 0.043 0.024 0.025 0.028 0.025
o oC-
5/4/81 5/4/81 5/4/81 5/4/81
0.040 0.017 0.010
(a) Analysis as described in Lab Method ES-567 ("Determination of Perfluorooctanoic Acid in Blood, Gas Chromatographic Method", S. Stafford, 4/3/81), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration standard.
(b) Although the analysis is specifically for perfluorooctanoate (acid or salts), concentrations are given in ppm fluorine for comparison with the results of total organic fluorine analyses, (ppm F = 0.688 x ppm perfluorooctanoic acid) Estimated uncertainty is + 10% relative standard deviation. The lower limit
*REDACTED*
EXP000014
EID713828
000073
2- -
for quantitation is 0.007 pgF/g. The detection limit is n- 0.004 pgF/g, but concentrations in that range cannot be well quantitated and are reported as < 0.007. None detected (n.d.) is reported for samples with [eg] < 0.004 ppm, which cannot be distinguished from reagent background.
j 00074
EXP000015
EID713829
