Document 6wy9rKOE52yMo5er1xyLJNVGg

August 1. 1969 Dr. J. E. Long ti.inager, Toxicology >1 Company 3M Center St. Paul, Minnesota 55101 Dear Jimi Harnrdlng vour request ooncernlnj^Aroo 1 or) 1232, 1248, and U.254, I trust the following wirr~ssrle your purpocei* ----- - Arcelor 1232 Aoutc oral LD50 - rat - 4470 mg/kg Acute olein minimal lethal dose - rabbit - >K.'GO <2000 mg/kg. Although no skin or eye irritation studies were done, vie know that the liquid Aroclors are good solvents for the normal fats and oils of the skin. Suffi cient akin contact than could lead to drying and chapping. For this reason we recommend that re peated or prolonged akin contaot be avoided. Vie do not have Inhalation data. Wo do not have breakdown products slnoe these are relatively stable compounds. Acuto oral LD50 - Rat - 12,500 mg/kg Acute skin minimum lethal dose - rabbit - >794 <1260 mg/kg. A study was made using a 4j< (w/v) solution in corn oil applied dally for 20 applications to the clipped Intact skin of rabbits at doses of 10, 50, and 100 mg/kg/day. The 10 mg/kg/day dose had no effect on body weight hematology and urine analyses when compared to the controls nor were there any gross or mioropathologlo findings. MONS 090*51 Dr. J. 8. Long August 1 1969 Pag* Two ArooXor T' (Continued) The 50 mg/kg/day doae produoed generalized inactivity, weakness, laaaitude, and loss of appetite. There were no significant looal skin reactions. Hema tology and urine analysea were comparable to the controls, arose pathologic examination revealed liver dlsooloratlon. All other tissues and organa were comparable to tha controls. Miaro pathologlo examination revealed moderate hepatic neoroals. All other tiasues and organa were comparable to the oontrola. The 100 mg/kg/day dose was more severe but comparable to the 50 mg/kg/day dose with regard to hematology, urine analysea, gross and micro pathologic examin ation. Wo do not have inhalation nor breakdown product data. ftro'clor iS5' ' Aoute oral LD50 - rat - 11,900 mg/kg Acute skin minimal lethal dose - rabbit >1260 <2000 mg/kg. 20 Day Subacute Dermal - Babbits Doses were 10, 50, 100, and 200 mg/kg/day. The LD50 was 75 mg/kg/day. No adverse reactions including hematology, urine analyses, gross or mioropathology, except after ten days sosllng and wrinkling of the skin, was observed from the 10 mg/kg/day dose. The 50, 100, and 200 mg/kg/day dose produced gener alized inactivity, weakness, lassitude and loss of appetite. The 200 mg/kg/day dose produced death before adverse skin reactions were observed. At the 50 and 100 mg/kg/day levels, there were akin reactions which revealed scaling, wrinkling and fissures. At these doses there were no effeots on hematology or urine analyses. Oroas pathologlo examination revealed liver dis coloration. However, all other tissues and organs wars comparable to the controls. HONS 090452 Dr. J. S. Long Ausuat 1, 1969 Pag# Three gp Day Subacute Dermal - Hnbblta (Continued) Microscopio examination revealed moderate liver necrosis. However, all other tissues and organa were comparable to the controls. We do not have Inhalation or breakdown data for this product. If your weather haa been anything like ours during July, you wouldn't ask such a silly question. Beat regards. Sincerely. William H. Hunt. Fh.D. Toxloologlat, Medical Sept. On HONS 090453