Document 6wnmoZpeoJ50EYNmQbmZ1pew1

`The study carried out by Environmental Health Associates on behalf of the U.S. Chemical Manufacturers Association is the largest and most informative investigation thus far undertaken." Sir Richard Doll Scand J Work Enviorn Health 1988; 14:61-78 GGB 3/15/94 RESTRICTED FOR USE WITHIN DOW AND DOW SUBSIDIARIES evzsnssu BENEFITS OF UPDATING INTER-INDUSTRY STUDY OF VINYL CHLORIDE WORKERS /W~dc Geodwffl' - Demonstrates to workers, community residents, customers, and other audiences our collective commitment to characterize any nealSi risks posed-by-eperatiHg~VCM/ PVC processes. , Ava Scientific Knowledge - Refines the estimate of the number of cases of human angiosarcoma of the liver (ASL)J^\f\ associated with operating VCM plants mthe pre-1972 era. A-- - Contributes ASL cases to the international registry. - Helps to resolve unanswered questions about alleged links to cancers of the brain, lung, and hematopoeitic system as well as address ether causes of death such as emphysema. Litigation Defense - VCM/PVC manufactureracontinue tnface / n toxic tort litigation allegingnumeroiis^pes( ^cn_ASL of cancer are related to VCM/PVC ^ V employment. This type of research is useful in defending such litigation. R&S146220 GGB 3/15/94 RESTRICTED FOR USE WITHIN DOW AND DOW SUBSIDIARIES BENEFITS OF UPDATING INTER-INDUSTRY STUDY OF VINYL CHLORIDE WORKERS (cont.) Chlorine Issue - VCM/PVC continue to be a part of the general debate on health and environmental impacts of chlorinated organics. This type of research serves a valuable role in helping to debate the issues on the basis of good science. GGB 3/15/94 RESTRICTED FOR USE WITHIN DOW AND DOW SUBSIDIARIES FUTURE VCM/FVC RESEARCH OPTIONS o\L. What has been the impact of the 1974 PEL reduction on the incidence of ASL and other cancers among VCM/PVC industry workers? 6^* Are there biomarkers of VCM exposure which could be used to better quantify worker exposures for future research into dose-response relationships? Besides cancer, are there other health effects one should be concerned about (i.e., fertility reproductive and developmental effects, endocrine effects, immune system, nervous system, other)? fstO With recent allegations of dioxin formation in the EDC/VCM process, are there additional health research studies needed? RESTRICTED FOR USE WITHIN DOW AND DOW SUBSIDIARIES