Document 6wXdERB6z3nOpadmjBegm3Zj3

lo Submitted to: BIOSEARCH, INC. pt.oe.lbeoxp8h5o98neph:iladel(ph2i1a,5)penns8yl4va8n-ia441991091 Project Number - 78-1161A 31 Company 3St. CePanutle,r Minnesota 55101 Material: Sample Received: 3H Company - T-2038CoC 1/5/78 Study Initiated: 1/9/78 Study Completed: 1/16/78 Date of Report: Test: Object of Test: 2/2/78 Primary Eve Irritation Study - Rabbits wThoicdhetetrhmeinseubjtehcetdemgatreereiaolf miaryritpartoidounc,e wIhfenany, instilled into the eyes of albino rabbits. Method of Test: aTnhde mienthtohdesgreandpilnogyedof inthethetesttestmiantge,riaelvalauraetitohnose danedscrAirbteidcleisn, SAedcmtiionnist1r5a0t0i.o4n2 a~ndHazEanrfdoorucsemeSnutbstRaengcuelsations, Federal Register, Vol. 38. No. 187, P. 27019, 27 September 1973. The sample was used as supplied. Sinixthhiesaltshtyudyy.oung0.1aduglntofalbtihenoexrpaebrbiimtesntwaelremautseerdial wwahsileinsthteilloetdherinetyoestheremraiignhted eyuenstroefatetdhe totessteravneimaasls Controls. The test material was not washed fron the eyes. : T5h6e t7rdeaaytsed efyoelslowwienrge eixnasmtiinleldatiaotn 1,of24t,he48tes&t7m2atherrsi.al& miandteo tihneaecyceosr.dancIentweirtphrettahteiognradoifngthesysrteesumltosutlwiansed Biyn tHhaezar"dIo1u1sustSruabtsetdancGeusi'd.e for Grading Eve Irritation Results: See Table 1. 004368 3H Company - T-2038CoC, Primary Eve Irritation Study. Conclusion: Based on the acconpanying table, the subject mwSaiettcehtriiinoanlth1e5I0s0d.ne4of2tinia(t6)iporni(m1)oafry(2t)ohceuP.lAacrt2-7R0ie1rf3reiratenandncter:equires no cautionary labeling with respect to that section. KDairrlectL.orGabriel, V.M.D., :Ph.D. 004369 TABLE 1 Grades for Ocular Lesions Material: 3M Company - T-2038CoC, as supplied. Rabbit No. Cornea Opacity Area Iris Conjunctivae fedness Chemosis Discharge 1 2 1 hour 3 i 56 1 2 24 hours i3 56 21 48 hours 3 I 65s 21 72 hours 34 56 : 1 2 5 days i3 56 1 2 7 days 3i 56 1 1 b4 11 11 11 11 0 1 0 4 o 1 1 1 1 1 1 1 01 04 00 11 1 1 1 1 0 0 0 0 0 1 1 1 1 1 1 00 00 0 11 1 1 1 1 00 00 00 11 11 11 00 00 00 00 0 0 0 0 0 0 00 00 0 0 0 0 0 00 00 0o 0 0 0 0 0 00 00 00 00 0 0 0 0 00 0 00 0 0 0 0 0 00 00 00 0 0 0 0 0 0 0 00 0 0 0 00 00 00 00 00 0 0 0 0 0 0 00 00 00 00 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 00 00 00 0 0 0 0 0 00 00 o0 00 0 0 0 0 004370