Document 6wONe2XnRw3JEQz2E1JVde19o

/ } / MICHIGAN DEPARTMENT OF HEALTH * ALBERT E. HEUST1S,M.D., Stale Health Commissioner * L A N SIN G 4, M IC H IG A N H IGH W AY M-174 T EL IVanhoe 4-1491 Ja n u a r y 3> i ? 6 l D o c t o r R o b e r t A. Keh oe K e t t e r in g La b o r a t o r y o f -Applied P h y sio lo gy U n iversity o f C in cin n ati C in c in n a t i, Ohio Dear D octor Keh oe: ,In t h e Jo u r n a l o f I n d u s t r i a l H y gie n e , Voltime 1 5 , 1933 "On t h e Form al A b sorption and E xcr e tio n o f Le ad ", P a r t 2 you l i s t two t a b le s sh ow in g t h e d i s t r i b u t i o n o f le a d in t i s s u e s o f p e o p le , I h ave t r i e d t o fin d r e p o r t s in l i t e r a t u r e o f l a t e r w ork p e r fo r m e d a lo n g t h e sam e l i n e s an d h ave n o t been a b le t o do so . In t h e w r it e u p , i t i s n o t made c l e a r w h eth er o r n o t t h e bon e marrow i s an aly ze d w ith t h e bon e sam ple o r w h eth er th e se two m a t e r ia ls ar e an alyzed se p a r a t e ly . Do y o u h a v e an y m ore r e c e n t w ork w h ich w ou ld g i v e in fo r m a t io n on t h e e x a c t l o c a t i o n o f l e a d in t h e human b o d y an d t h e m ech an ism b y w h ich i t i s rem oved and c a r r ie d in th e blood str eam . A r e c e n t a r t i c l e im p lie s t h a t t h e le a d in t h e b lo o d st r e am i s c a r r ie d a s a l o o s e l y h e ld compound on t h e r e d b lo o d c e l l s an d t h a t t h e a d m i n i s t r a t i o n o f EDTA compound m erely rem oves t h is lo o se ly bound le a d an d i t i s excreted via. th e k id n e y s. The a r t i c l e a l s o im p lie s t h a t t h e r e may b e a d d i t i o n a l le a d boun d i n s i d e o f t h e r e d c e l l s t h e m se lv e s. Can you su p p ly an y in fo r m a t io n t h a t w ould c l a r i f y t h e r e c e n t t h in k in g on t h e d e p o sit io n and r em oval from t h e d e p o sit io n s i t e o f le a d d e p o sit e d in t h e bon e o r bon e marrow? Very t r u ly y ou rs, JD T : hma Jac k D. T orrey P u b lic H ealth Con su ltan t DIVISIO N OF OCCUPATIONAL HEALTH K 000 / 4 V9