Document 6wO6B48VkwwoYnmodJR1Oz8qo
NORTHERN KENTUCKY OFFICE
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Robert a . Bilott
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August 26, 2002
CERTIFIED MAIL NO. 7002 0860 0006 6119 4910 RETURN RECEIPT REQUESTED
IRIS Submission Desk c/o ASRC 6301 Ivy Lane, Suite 300 Greenbelt, MD 20770
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Re: IRIS Submission Inventory for Perfluor ictanoic Acid - Ammonium Salt fCAS No. 3825-26-11______________
IRIS Submission Desk:
On April 12, 2002, we submitted information to you in connection with the referenced IRIS Submission Inventory, pursuant to a January 9, 2002 notice in the Federal Register (627 Fed. Reg. 1214 (Jan. 9, 2002)). We are hereby supplementing our April 12, 2002. submission by referencing the following additional information relating to the chemical at issue, copies of which are available from our files:
1. Keller, Yamanaka, and Thurman, "Inhibition of Mitochondrial Respiration and Oxygen - Dependant Hepatotoxicity By Six Structurally Dissimilar Peroxisomal Proliferating Agents," Toxicology 49-61 (1992);
2. Keller, Marsman, et al, "Several Non-Genotoxic Carcinogens Uncouple Mitochondrial Oxidative Phosphorylation," 1102 Biochemica et Biophysia Acta. 237-44(1992);
3. Panaretakis, Shabalina, et al, "Reactive Oxygen Species and Mitochondria Mediate the Induction of Apoptosis in Human Hepatoma HepG2 Cells by the Rodent Peroxisome Proliferator and Hepatocarcinogen, Pefluorooctanoic Acid," 173 Toxicology and Applied Pharmacology 56-64 (2001);
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4. Berthiaume and Wallace, "Perfluorooctanoate, Perfluorooctanesulfonate, and N-Ethyl Periluorooctanesulfonamido Ethanol; Peroxisome Proliferation and Mitochondrial Biogenesis," 129 Toxicology Letters 23-32 (2002);
5. Starkov and Wallace, "Structural Determinants of Fluorochemical-Induced Mitochondrial Dysfunction," 66 Toxicological Sciences 244-252 (2002);
6. Fosslien, "Review: Mitochondrial Medicine - Molecular Pathology of Defective Oxidative Phosphorylation," 31 Annals o f Clin. & Lab. Sciences 25-67 (2001);
7. Wallace and Starkov"Mitochondrial Targets of Drug Toxicity," 40 Annu. Rev. Pharmocol. Toxicol. 353-88 (2000);
8. Wallace, "Molecular Mechanisms of Perfluorooctanesulfonate Toxicity," (March 2002 SOT Presentation); and
9. Purdy, "Perfluoroalkyl Anions: The Case for Aggregation to Develop SARs and Assess Risk," (Nov. 2001 SETAC Presentation).
RAB/jrt cc: R. Edison Hill. Esq.
Larry A. Winter, Esq. Gerald J. Rapien, Esq. Jennifer Seed (USEPA)
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