Document 6wG8BJN3mkj64MrMN17LMonzE

<*tobr 23, 1959 *n mib Jbr. I. Wilbur dpslthor Adainlstrator, Industrial Kygisno Wootlnghouso Usstrls Corporation Sari Pittsburgh, ponosylrania Bm t Olttft /cm for tout lotto? of Ootobsr 21 inquirlnc about tho of 6tr0i0shhlaaaraoohdi1pobroondyiplhaannyd1a. aixturs of 400 triahloro- Tbs saiblnais k n o w saablnation is our ~ O m shyslsal and shwltal proportioa of tha Aroalors aontloood Aroalor bullotln* tosloaod also is a roprint 1ndlasting tho of tnaisity studios with Arooloro^SArand 125*. folloulng s< its snsasring your questions sorlally inforaatl in these bulletins. Z bolisTO prolonged sod ropoatod akin oontast with any of tho Arcelor* would bo aroidod for two reasons, rIn the first flaoo, the loos shlerlnatod produsts ard liquids and art oxoolont solvent* for oils and fata in tho akin as n i l as other orgonle aaterlals fteaendly. it Is possibla that proloncad or ropoatod akin ssntaot aould load to ahloraeae. Z too of only history of production and uso of tho Aroel an Aroolor oas being uaod as a boat tranof that i tho 6ocry developed by an industrial physisian but W ish in his slgniflsant that m asn were not aaaro of general proatltlanar notiss then. This lad in a ays t- so in would o # C8RN 00000 88 c C / cc Hr. 8 Yilbur fptiihtr-- Page 2--October 23, 1959 that sufficient exposure, leather by Inhalation of vapor or sldJi contact, can result in chlortcne which I think we oust assume could bo an Indiaation of more serious systemic injury if the exposure v u allowed to continue. A second u m of mild ohlaraane about which we havo any' knowledge resulted from worlaaen dipping their hand in tha liquid Aroelor a if it war mineral oil or vagatabla oil.. Zn addition, thalr olothing eoonar or latar became impregnated with tha notarial and thua exposure m magnified You aakad at what taotparatura local exhaust ventilation should ba provided. Although tha distillation range for Aroelor 1242 is 325-360C. end 3fl5-420OC. for Aroolor 1260, I feel that good prastlsa dietstea that looal exhaust ventilation ba provided whan eay of tha Aroelor are heated above 1507. in open tanks or in any systems where the aaterlal is not in a completely enclosed system (vaper-proof tanka, kettle, puaps, piping, eta,) This aay be ultra conservative because as the distil lation ranges and vapor pressure curves (page 12 of the Aroelor bulletin) Indicate, the Iocs of vapor at 1507 . should not ba signlflsant except in any work area where general ventilation or air changes do not sxlst Your next question related again to possible kin and systemic effect and I believe it la answered above. In aonnactlon with tha 40 trlchlorobensne-60 Aroelor 1260 combination, Z believe the thoughts expressed above also apply. Z understand that tha trichlorobenxene tdvleh 1 used la a Disturb of the 1,2,3* 1,2,4-, and 1,3,5-isomers which will begin to distill at 205C. Again, Z belltve this indicates a low vapor pressure far the solvent st room temperatures. The only reference we have to triehlarobenxsoe atoxicity is con tained in the Public Health Service Publication Ho, 414 entitled "The Halogenated ^rdrocarbona Toxicity and Potential Sanger" by Or. V P. von Oettingen, 0,A. 0overrent Printing Office, 1955 (pages 297-296) Sr. von Oettingen refers to some work done in 937 which indicated that the trlehlorobenseae was less toxla than mono or dlehlarobensane. Zn ay opinion, a reasonable MAC for this aaterlal would be 100 parts per million The enclosed publication on the toxicity of Aroelor 1242 and 1254 suggests an MAC for 1242 of 2 milligrams per eubla meter which is twlse that recommended by the ACQ1H far a chlorinated di phenyl of unstated chlorine oontent. Zn the ease of 1254, the publication suggests that the MAC of 1 milligram per cubic meter "reeomwended tentatively for cafe industrial practice by the Aacrloaa Conference of Oovcrrmental Industrial Hygienists is reasonable On the other hand, reference te Henry Anyth's Cummings Memorial Lecture of 1956 in which he Alienseed the basic for the then existing "hygienic standards" indicates that GBRN 000003 89