Document 6wEEMry3qO8VkG31bGdENq1Rd
Brain Tumors In Chemical Workers Presentation before Johns Hopkins' Sixth Annual Symposium
on Olagnosis and Treatment of Neoplastic Disorders April 10, 1980
Victor Alexander, M.Q., M,S.P.H. Medical Officer Occupational Safety and Health Administration U.S. Department of Labor
AP00020233
Experimental Brain Carcinogens
2- Acetylamlnofluorene Acrylonitrile
1-Aryl-3,3-Oialkyltrlazenes
Azoethane (prenatal)
Azoxyethane (prenatal)
`
Azoxymethant
Butylnltrosourea
Cycasln
l,2-01ethylhydrazine Oiethylnltrosamine (prenatal)
Diethyl Sulfate (prenatal)
Dimethyl Sulfate (prenatal)
Elalomycln
Ethyl methanesulphonate Ethylnitrosobiuret (prenatal) Ethylnltrosourea (prenatal) 1-Methyl-2-Benzyl-Hydrazine (prenatal)
Methyl methanesulphonate Methylnitrosourea (prenatal) Methylnitrosourethane (Intraplacental) Procarbazine (prenatal) Propane Sultone Propylene Jmlne Pyrrollzidine Alkaloids
Vinyl Chloride
-I-
(Vasque2, 1945) (Maltonl et al., 1977)
(Druckrey, 1973) (Zulch and Mennel, 1973) (Zulch and Mennel, 1973)
(Qruckrey, 1973) (Taklzawa and Nishlhara, 1971)
(Hlrono et al1968) (Druckrey, 1973) (Druckrey, 1973)
(Druckrey et al., 1970) (Druckrey et al., 1970)
(Schoental, 1969) (Swann and Magee, 1969)
(Zulch and Mennel, 1973)
(Ivankovic, 1973) (Druckrey, 1973) (Magee, 1973}
(Alexandrov, 1969) (Napalkov, 1973)
(Ivankovic, 1973) (U1land et al., 1971) (Ulland et al., 1971) . (Schoental and Cavanagh, 1972)
(Maltonl, 1976)
AP00020234
Epidemiological Studies: Clues to Human 8ra1n Cancer etiology
Aluminum Workers Anti-Convulsant use Autoworkers-Pattern Makers Farm/Rural Residents Geographic Clustering-^ Kentucky)
(Rhone Valley) Halomethanes in Drinking Water Lead Smelter Workers Machinists Petrochemical Workers Rubber Workers Toxoplasmosis Vinyl Chloride Workers
(Milham, 1976) (Clauiresen, 1974) (Robinson et al., 1980) (Choi et al., 1970)
(8rooks, 1972) (TrouilUs et al., 1975)
(Cantor et al., 1978) (Cooper, 1976)
(DeCoufle, 1978) {Thomas et al., 1980) (Mancuso et al., 1963) (Schuman et al., 1967) (Tabershaw and Gaffey, 1974)
-2-
AP00020235
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Table 4
Observed and Expected Deaths Anong Deceased National Pattern Makers' League Members by Predominant Work Detween 1940-1960**
Cause
8th Revision!
I CPA
|
Predominantly Wood Obs. Exp. PMR
Predominantly Metal Obs. Exp. PMR
All malignant neoplasms Oigestive System
Esophagus Stomach Co Ion
Rectum Gall Bladder
Other Digestive System Nose. Nasal Sinuses lung
Skin
Urinary Bladder Kidney Lymphatic and Hematopoietic System
Hodgkin's Disease Other Lymphomas Multiple Myeloma Leukemia
Other Lymphatic and
Hematopoietic Other Malignant Neoplasms Brain Tumors, Both Malignant and Unspecified Diseases of Circulatory System Diseases of Respiratory System
All Accidents and Violence All Other Causes
(140-209) (150-159)
(150)
(151) (153) (154)
(156)
(152,155,157-159) (160)
062) (171-172)
(168)
` 069) (200-209)
(201)
(200-202) (203)
(204-207)
205 63
4
5 30
9 2 13 0
48 S
11
5 24
0 7 3 14
180.9 49.5
4.0 0.1 18.4 5.3
1.5 12.2
0.3 56.3
2.S 7.3
3.9 16.1 0.9 4.7 2.5 7.0
113 127 100 62
163 170
133 107
0 85 200 151 128 149
0 149 120 200*
(208-209)
0 0.9 0 49 45.0 109
(191-192,238) (390-158) (460-519) (800-999)
(7) 520
# A V4
33 86
(.0) 524.2
. 71.6 38.3 91.0
175 99 87 86
95
73 71.7 25 19.3
1 1.6 4 3.1 13 7.1 1 2.0
3 . 0.5 3 4.9
0 0.1
23 23.2
0 1.0 3 2.7 3 1.6 7 6.4 0 0.4
2 1.9 1 1.0 1 2.7
102 130 62 129
163 50 500 61
0
99 0
111
168 109
0 10S 100 37
3 0.3 1000
12 17.4
69
(5) 201
27 10
`35
(1-7) 194.8 26.4
17.4
35.7
294 103 102 57
98
All Causes
T5 T5S
TOtf
3T& 346
"TO
* p*0.05
** 5 members could not be classified
[Table from Robinson et al., 1980]
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o Ooo
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19
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S 9 0 4
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71 --
17 _
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749 140: 77 19 b 1 3*
7 S
7 4
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19 -
7 ft J 1 II 4 4 ft ft 04
Tftbte 9. - Mort*f tor Selected Cancer Sites to WMe Mete OCAW Mimbm topum al Pbt A by leftftb ftl IMw MwwbmMft.
Site ffttb fltWilM. cot
Stamxh pM) 9>4m ft central rmveus system (lit. 1971
< it ram < ^ lftt| * E| tmn 3 14
Oft-
iMeth U WemftwiM WII IMl (ft 177)
1 PM
t 77
S IS 3J7t
0 s Observed deaths
fE = Erpctled OemM basedd* moyert--*e nartoM) to VI5 wWe metes
JSliMhtjAy bgndicjnt * Ifm 0.06 (met
-Nl CMCBtotvd
7ft leers 0 S I37| 0 E PMft s is 3 re:
4 l.l
[Tables fro* Thomas et al., 1980]
i
AP00020240
Texas Petrochemical Plant PMR Mortality Study
Causes of Death: 08/27/49 - 01/01/79
No. Per cent
Cancer -[All Types)
ni 24,0
Oral Cancer
1 0.9
Digestive
34 30.6
Respiratory
27 24.3
Genital
$ 5.4
Urinary
5.4
Bone, Skin Breast
5 4.5
Lymphatic
13 11.7
Neoplasms Brain
JQ 9.0
Hlsc. & Unspecified
9
3.0
1975 Texas
2.39 25.7 26.69 11.6
3.99 10.26 9.9 2.16 9.9
Cardiac Respiratory Digestive Liver Gen1to-Urinary Trauma Cerebro-fascular Miscellaneous Unknown
180 39.5 lo 21.9 5 1.09
.
9 1.9 6 1.3
64 14.0 27 5.9
8 1.7 ) 35 7.69 J
455
1975 Galveston Count
20.4 (City)
3.9 ' 26.5
25.2 10.2 4.59 6. S3 12.73 2.62
1975 Galveston City
36.6 2.5
1.4
2.2
1.7
8.8
13.0
-8 -
AP00020241
Brain Cancer Bibliography
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-9-
AP00020242
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- 10 -
APO6626243
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AP00020244
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