Document 6wDaGKVngkjBrNXGwYqJwEjQ9
INTEROFFICE MEMORANDUM
To Distribution __ From J. T. Barr _
Distribution: R. Fleming Ek"#. Schenck *u. B. Tepper, M.D.
^ Subject _-..
Date 23 February 1978 ASHA Testimony___________________
(Location. Organisation, or Department)
Plastics -R&D__________________
(Location, Organiaalion, or Department)
cc: 6. Baise - Beveridge, Fairbanks, & Diamond
I have prepared a brief summary of the major issues in the testimony to OSHA of the AIHC consultants whose draft documents we have reviewed. These drafts are available in my office.
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VOLUME I
NO. 1
NAME AND DEGREE(S)
Richard Wilson - PhD
PRESENT AFFILIATION
Harvard
MAJOR AREA OF INTEREST Nuclear Physics
MAJOR TESTIMONY POINTS Risk/Benefit Examples of acceptable risk
VOLUME I
NO. 2
NAME AND DEGREE(S)
George Claus - SD, PhD, MD
PRESENT AFFILIATION
Rutgers and others
MAJOR AREA OF INTEREST Microbiology
MAJOR TESTIMONY POINTS
VOLUME I
NO. 3
NAME AND DEGREE(S)
Life Cycle of tumors, benign vs. malignant Appropriate routes of Administration Thresholds Single species test Value of negative Research
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Ronald W. Hart - PhD
PRESENT AFFILIATION
Ohio State
MAJOR AREA OF INTEREST Physiology and Biophysics
MAJOR TESTIMONY POINTS
Extrapolation of animals to man Thresholds
Use of future scientific developments DNA damage and repair
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VOLUME I
NO. 4
NAME AND DEGREE(S)
Johannes Clemmesen - MD, DM
PRESENT AFFILIATION
Finsen Institute - Copenhagen
MAJOR AREA OF INTEREST Epidemiology
MAJOR TESTIMONY POINTS
Danish Cancer Registry
Effect of lifestyle on cancer rate Environmental vs. industrial cancer Value of negative human epidemiology (phenobarbital) Difficulties with animal data
VOLUME I
NO. 5
NAME AND DEGREE(S)
L. J. Goldwater - MD, DMS, MS Public Health
PRESENT AFFILIATION
Duke, UNC
MAJOR AREA OF INTEREST Occupational and Environmental Medicine
MAJOR TESTIMONY POINTS Threshold
VOLUME 1
NO.
NAME AND DEGREE(S)
6 A. E. M. McLean - MD, PhD
PRESENT AFFILIATION
University of London
MAJOR AREA OF INTEREST Toxicology, Pharmacokinetics
MAJOR TESTIMONY POINTS
Potency Extrapolation of animals to man Risk/Benefit evaluation Phenobarbital experience Exemption of laboratories
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VOLUME I
NO. 7
NAME AND DEGREE(S)
PRESENT AFFILIATION
Paul Grasso - MD, Dip. Chem. Path., MRC Path. BI8RA
MAJOR AREA OF INTEREST
MAJOR TESTIMONY POINTS Difficulties of extrapolating mouse data to man
VOLUME I
NO. S
NAME AND DEGREE{S)
R. F. Crampton - MD, PhD
PRESENT AFFILIATION
Bibra
MAJOR AREA OF INTEREST
MAJOR TESTIMONY POINTS Difficulties of extrapolating mouse data to man
VOLUME II
NO.
NAME AND DEGREE(S)
1
David Brunswick - PhD
PRESENT AFFILIATION
Litton Bionetics
MAJOR AREA OF INTEREST Genetics and Microbiology
MAJOR TESTIMONY POINTS
DNA damage and mechanism of tumor induction Applicability of short-term tests
Thresholds
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VOLUME II
NO. 2
NAME AND DEGREE(S)
R. F. Olson - MD, PhD
PRESENT AFFILIATION
University of St. Louis
MAJOR AREA OF INTEREST Metabolism, toxicity, mutation
MAJOR TESTIMONY POINTS
VOLUME II
NO. 3
NAME AND DEGREE(S)
No epidemic of cancer Animal results not suitable Negative human epidemiology useful Thresholds Maximum dosage, dose response Replication of tests
Franck Lu - MD
PRESENT AFFILIATION
University of Miami (formerly WHO)
MAJOR AREA OF INTEREST Pharmacology and toxicity
MAJOR TESTIMONY POINTS
Value of testing only one species Value of negative results
Threshold values
VOLUME II
NO. 4
NAME AND DEGREE(S)
B. L. Oser - PhD
PRESENT AFFILIATION
Retired FDA
MAJOR AREA OF INTEREST Physicological chemistry
MAJOR TESTIMONY POINTS
Thresholds (attempts to quantify) Requirements for adequate animal tests
AP00049583
VOLUME II
NO. 5
NAME AND DEGREES
H. Van Raalte - MD, DM
PRESENT AFFILIATION
Lecturer Amsterdam and elswhere Retired from Shell
MAJOR AREA OF INTEREST Occupational medicine and toxicology
MAJOR TESTIMONY POINTS Cancer rats of industrial vs. non-industrial countries Environmental factor
Freezing of science Extrapolation of animals to man Causes of cancer
AP00049584