Document 6w8EzoKwmQ86edRnmy7MOD8x3

.MEMORANDUM TO: MRQM: DATS: Dr. Kehoe Dr. C leveland I - 28-65 RE: S ta tu s of' p r o j e c t s In th e T o x ic o lo g y D iv is io n - S ponsor - S h e ll C hem ical Company , 1. Vapona I n s e c t i c i d e Pro gram. A. R a ts w e re f e d on d i e t s c o n t a i n i n g vapona I n s e c t i c i d e i n c o n c e n t r a t i o n o f 0 . 1 , 1 . 0 , 1 0 . 0 , 1 0 0 . 0 , a n d 1 0 0 0 .0 ppm fo r a p erio d of f i f t e e n weeks. This phase of the work is completed and has been rep o rte d . 3. R ats have been f e d on d i e t s c o n ta in in g Vapona in c o n c e n t r a t i o n o f 0 . 1 , 1 . 0 , 1 0 . 0 , 1 0 0 .0 a n d 500..0 ppm f o r a p p ro x im ate ly 17 months. This phase w i l l be com pleted S e p te m b e r 1, 1965. G. Dogs have b e e n fed. on d i e t s c o n t a i n i n g Vapona i n c o n c e n t r a t i o n s o f 0 . 1 , 1 . 0 , 1 0 . 0 , 1 0 0 . 0 , a n d 500* 0 ppm f o r 13 m onths. T h is p h a se o f t h e p ro g ram w i l l be c o m p le te d In D ecem ber, 1965. D. R a t s h a v e b e e n f e d on d i e t s c o n t a i n i n g Vapona i n c o n c e n t r a t i o n s o f 0 . 1 , 1 . 0 , 1 0 .0 , 1 0 0 .0 an d pOO.O ppm and the o r ig in a l anim als and subsequent l i t t e r s have been mated through 3 su ccessiv e g e n e ra tio n s. This phase of the program had ju s t been completed and the re p o rt Is being w ritte n . I f p ossible th is rep o rt should reach S hell Chem ical Company a s e a r l y in F e b ru a ry as p o s s ib le as th e y should lik e to include i t In a p e titio n th a t is being sub m i t t e d t o FDA. D ie la rln Program F iv e groups of monkeys a re b ein g fe d on d i e t s eont a in in g D ield In in c o n c e n tr t io n s of 0.05* 0 .1 ,' 0 .5 , 1 .0 , a n d 1 .7 5 PP. T ills p r p grain. lias t e e n u n d e rw a y f o r a p e r i o d o f 16 m onths and was s c h e d u l e d f o r two y e a r p e r i o d t e n t a t l v e l y e n d i n g i n S e p t e m b e r ,. 1965, a l t h o u g h Dr Zavon hopes to co n tin u e th is as a longer- term p r o je c t. . Sponsor - Sthyl Corporation - vno-n , - 1- l -- ^ * | ) | This is a very sm all p ro je c t involving approxim ately 5 dogs and has been underway app ro xim ately 2 y e a rs, having been continued a f t e r the com pletion of a 90 day program. The purpose is t o d eterm in e when th e an im als re a c h e q u ilib riu m a f t e r c o n t i n u e d i n g e s t i o n o f 702-C ^j, . sm alr p ro ject determ ining the cnam e per of u r in a r y m e ta b o lite s o f 702. The a c t u a l work 1 ; com pleted ana the rep o rt is in prep aratio n . Sponsor - united S tates Public H ealth Service 1. Lung can cer p r o je c t. This in v o lv es th e in h a la tio n of c o a l t a r fumes T h i s i s a t h r e e y e a r p r o j e c t i n i t i a t e d S e p te m b e r 1, i 960 'CO minate S e p te m b e r 1, 1;- cr The w o rk i s a p p r o x i m a t e 1er 6 months behind sch ed u le and p ro b a b ly w i l l need to be extended f o r a p e rio d of 6 months w ithout a d d itio n a l funds, alth o u g h h r. ly e is co n sid erin g su b m ittin g a proposal fo r renew al and requesting ad d itio n al funds. .In se ct!cid e "'Project,, ' This Is a program to determ ine the presence of c h l o r i n a t e d i n s e c t i c i d e s In human fa t* d e v e lo p in g methods w ith th e gas chroiip to g rap h . The work w a s. begun O ctober 1. 1954 and te rm in a te s O ctobsr 1, 19S6. Sponsor - Colony Development C orporation Program should begin approxim ately m id-February, 1965 an d be c o m p l e t e d by t h e en d o f 1965 T h is i n v o l v e s a n a ly tic a l work by Hr. Tye and B io lo g ic a l work by Dr. Bingham. The l a t t e r p o r t io n of t h e program w i l l p ro b a b ly e x t e n d i n t o i 960. Sponsor - Socony Mobil O il 1. Work on c a r c i n o g e n e s i s . Work i s e x p e c te d t o c o n t i n u e t h r o u g h J u l y , i 960. Sponsor - American O il Company 1. E x p e rim e n ta l work begun in J a n u a ry and August of 1964 a n d c o n t i n u e s t o J a n u a r y , 1966. Sponsor - S tandard O il of Ohio 1. . Work begun in -March, 1964 and c o n tin u e s th ro u g h O c to b e r , 1965. Public H ealth Service Grant 43-64-45 This is a two year c o n tra c t and began in Septem ber, 1963 a n d t e r m i n a t e s S e p te m b e r , 1965. Dr. Bingham w i l l a p p ly f o r a renew al of th e g ra n t i n s p r i n g o f 1965. Array Conferacfc DA-1S-108-AMC-170A This, is a two y ear c o n tra c t d e a lin g Tilth pulmonary p h y sio lo g y conducted by D r.S te m m e r, The te rm in a tio n of th e f i r s t c o n t r a c t i s i n Ju n e o f 1965. A two y e a r e x t e n s i o n o f th e program has been approved. U. S . P u b l i c H e a l t h S e r v i c e G ra n t OOH-OOI65-O I ' This is a re s e a rc h program involving the to x ic ity of t r i v a l e n t chromium, being conducted by Jim P ie rce and in p a r t s u p e rv is e d by Dr. Stemmer. Army C o n t r a c t M-33-OQ8-AMC-239 T his is a program of 9 months d u ra tio n to e v a lu a te the a n ti-p e rs o n n e l e ffic a c jr of a flam e p ro je c to r expendable one sh o t. Army C o n t r a c t DA-33-008-AMC~266X . . This is a c o n tr a c t f o r a p e rio d of 9 months and co n sists of basic research involving the in v e stig a tio n of magnesium te f lo n . On t h e s e tw o c o n t r a c t s D r. F r a n k P. C l e v e l a n d i s d e s i g n a t e d a s t h e p r i n c i p l e i n v e s t i g a t o r . On p a g e 2 o f t h e c o n t r a c t , p a r a g r a p h e_ t h e r e i s t h e d e s i g n a t i o n o f t h e personnel. . Army C o n t r a c t DA-I8-106-CM L-6628 . This is a su b c o n trac t from C o rn ell A ero n au tical Laboratory and is a basic resea rch p ro jec t re la tin g the physiological e ffe c ts of pyrophoric agents. -5 - Sp-ont or ' - .-2a;t o h :~I g b o r a t o r y ' T his i s a p r o j e c t in v o lv in g human v o lu n te e r s u sin g chlorapepfclc a s p rescrib ed and determ ining the ex cretio n of p h e n o l. The p r o j e c t i s c o m p lete d . The r e p o r t i s i n - p r o g r e s s . 3 p ons o r - e I s 1c o 1 1. -hnvel D This is a re p ro d u c tio n experim ent to be c a r r ie d th ro u g h 3 g e n e r a tio n s in r a t s b e in g fe d on v a rio u s d i e t a r y c o n c e n t r a t i o n s o f B a n v e l D. The f i r s t g e n e r a t i o n h a s been com pleted. The second and t h i r d g e n e ra tio n s w i l l proceed a n d t h e p r o j e c t w i l l be c o m p le te d i n 1965. 2. H eptaehlor and a m ixture of H eptachlor and H eptachlor E p o x id e . This a ls o is a rep ro d u ctio n experim ent c a rrie d th ro u g h 3 g e n e r a tio n s . I t is in th e same s ta g e as th e B a n v e l D. The f i r s t g e n e r a t i o n has b e e n c o m p l e t e d and t h e s e c o n d an d t h i r d g e n e r a t i o n s w i l l be c o m p le t e d i n I 9S5. D ichlor-os a l i e y l i c Acid R a d io tr a c e r T h is i n v o l v e s t h e d i s t r i b u t i o n a n d e x c r e t i o n oT d i c h l o r o s a l i c y l i c a c i d and i t s m e ta b o lite s in r a t s . I t was begun O ctober 1, 1964. The e x p e rim e n ta l work i s co m p leted . A n a l y s e s a r e I n p r o g r e s s a n d s h o u l d be c o m p l e t e d on or- a b o u t F e b r u a r y 1. The r e p o r t t o be c o m p le te d a p p r o x i m a t e ly March 1. Future P o ten tial I have d is c u s s e d a b a sic r e s e a r c h program to be . sponsored by V e lsic o l In the f i e l d of ra d io tra c e rs and re la t i n to th e c h l o r i n a t e d I n s e c t i c i d e s . E s tim a te d c o s t was $10, 000 p e r y e a r . V e l s i c o l i s i n t e r e s t e d b u t t h i s has t o be consummated. : / - discussions' have been held w ith H orizons,' Inc. of C lev e la n d , Ohio p e rta in in g to th e i n i t i a t i o n of a program to evaluate the genic p o te n tia l of c e rta in free ra d ic a l Oiompounds. The prim e c o n t r a c t w a l l he from t h e IIIB t o Horizons and th e y w ill su b co n tract the b io lo g ic a l w ork'to a s . F in a l agreem ents have to he p rep a red . A proposal is being prepared fo r E thyl Corporation fo r th e long terra e f f e c ts of 702 in r a t s and dogs and w ill in c lu d e a 3 g e n e r a tio n r e p r o d u c tio n e x p e rim e n t. The p ro p o s a l is being prepared fo r co n sid eratio n by p th y l. B r a c k e tt Company has i n d ic a t e d t h a t th e y w ish t o have a new fo rm u la tio n of t h e i r s i l v e r p o lis h in v e s tig a te d f o r d e te rm in a tio n of i t s t o x i c i t y . This sh o u ld be awarded In February. H' KT 0019367