Document 6w6OzeKrD7vjGZq2k7VnnwY51

y;. r, v/necKT - moo? on! !);*>>L. January 21, 19^9 Arog 1or(Wi1dlife) vs. Pesticides V/. R. Richard WHICH .r-R. K.-Kc-ner - Oi-vY-v. 'Vi. K. 0)iiniio;i C. raten - CrATO K. A. Wells - KV.'ELL R. E. Kelly - RKELL Recently .1 asked Jack Garrett to put on paper the formulae for common chlorinated hydrocarbon insecticides since, many of us. have wondered whether or not any of them viere likely candidates for metabolizing to PCBs. Jack's comments follow: HAs you know, Mr. A. Richardson of Shell in Hreat Britain did soma vrork on the extracts of marine bird eggs (using the specimen nhg or phalacrocorax aristotelis), Mass spectroscopy of a fraction from a silica gel column showed the presence of a compound of molecular weight 126. Gasliquid chromatography-mass analysis indicated compounds of'mass 324, 35o> 392 and 126. These molecular weights correspond to 5j 6, 7 find 8 chlorinated biphenyl. The Swedish work indicated the same results, however all. workers suggested that the material found in nen pre-; treated specimens was the higher chlorinated biphenyl. There are a great many peeks that fall close to the socalled PCS peaks in the GBC-EC readouts that are identified as chlorinated -pesticides and/or their identified metabolites. I. have listed bclov: several pesticides and pesticide metabolites.along with their structure and molecular weight: NEV 031177 780715 7 *94 / / /. J * -> -> a . __ '.. r? 'i *C-V// j :,/,!../ * r .. V i . H N, Vr' *f X/ /*/>' >> /. 7, / t CW; 7, .'ip - c./-;/x'r<xp/:- fc**y ` Cu-C' cu A/|7.-0 - 3/8 - h |,r|p :A !' L/> 2 >.?,/., ,;V /jcyviC'/jLofto I, <,4/5'/ Sftv>`hc'Mhyc}.?.**' \-,A cj4oc-.>s , & el ( /v-'- /.. >. y- S ' Y ' Y '* M l - 3 3 tt * O t e ! . L h 2A i,tyl# Ac&cl'/ee* Sj leposy <y7-.vvv.? . 9>V/>>'-fjV i'*'-*>Vc.>'* "A'VrVAr/^VfO/?//;.<!/,v.;: 3 Jj' ^ /i/ A'./' iv< *;,-1 r IvCLI Cl.Cfti.h- ; - S ' \ - L k J / 'C L "T ei a 32/ L1 1 ; i LV " L_ - fjci-nj r ,A A y l /l-'-'^c/:U'.o ,7ex*?,it4f 7,Sr;:*.w oc*A}>>;*.':* /j'h evMw.i*' ? C`!/,*.: V /,-/V/ .V.*'y->A Y //''-J n / \ I1C: : ;i 7>ft*\1 11 1l i .N v vil.; * CV & . U J r* Z;?/ NEV 031178 780716 ' 3 /-/, P /!/! ZV.7 >> /)(:... ./ i w.>r^/c,.f/o orc / %* wJC Cf/ri:/:V/J:J. y.'jj Cj/c./A / % >.t /.[voc:;./..Ve /\ /J*.;-,`i;c ya / /.*k Ja .\V.y fw,I-U 29 ! C hA '* /> AV. /_7 3/->.*?,^ 7,-' ? *.J^ * V'C VVA f,'r'/cv1 ^ 7 AjV'/A,y&/AS'J0 % /-/='/--//-/> LlA;/0;Z. `V ' / Cz / C!<* Jt- 'j'< 'i i'J . '~Jj 7 7 <} //Vwv)/1. ' S.\J P') tU) r iS/ .T; IO. P O g //> h l-C/V. /{,. /,/^/ \ .?.:** - t**:(/&?//, '/-'v>c vyA ) <7*//?/?'VOJ7 i ) f'*(? O", vO ^ ' . 'S .'A-. \ ..-^A n \ ....... NfcV 31 17 9 ra 780717 The molecular weights are only approximate based on I C*sl2# }!"!* 0--1 6 ; CLA=3i3*5* V/e arc not cure v/hat happens to these pesticldes--at least not all of them-- in the avarian metabolism. It Is possible that scrr.e metabolites form in marine birds fron; chlorinntet!"pcrsticiees that correspond to the pea!:s . found by GLC-EC ana also to the molecular weights. The more confusing aspect of this problem is the chance that the ultimate problem is the result of tho me taboilsin. of marine food soccios (floh and other marine bird food orgr.nisms) possibly further metabolized by the bird itself." EPW:cjs f{\ ) Elmer P. W'heeler NfcV 0 3 1 1 8 0 780718