Document 6w5bedbvmMVjBK3QN99wjNBQ4

h AIW-oHii BIOSEARCH, INC. p.o. box 8598 Philadelphia. Pennsylvania 19 10 1 telephone: (215) 848-4499 Submitted to: Material : Sample Received: Date of Report: Test : Object of Test: Method of Test: 3M Company 3M Center St. Paul, Minnesota 55101 3M Company - T-1395 December 6, 1975 March 4, 1976 Primary Skin Ir r it a tio n Study - Rabbits To determine the degree of ir r it a t io n , i f any, which the subject material may produce when applied to the intact and abraded skin of albino rabbits. The test was performed in order to c la s s ify this m aterial under the Federal Hazardous Substances Labeling Act. The method employed in the te s tin g , evaluation and the scoring of the results was s im ila r to that described in Section 1500.41 - Hazardous Substances and A r tic le s , Administration and Enforcement Regulations, Federal R eg ister, V o l. 38, No. 187, P- 27019, 27 September 1973- In carrying out the study the experimental sample was used as supplied. A group o f six albino rabbits were clipped over a wide area. One side of the animals' backs was abraded at one s it e with a lancet s u f fic ie n t ly deep to penetrate the stratum corneum but not enter the derma to produce bleeding. The skin of the other side was allowed to remain in ta ct. A 0.5 gm portion of material was applied to an abraded and an intact skin s ite on the same rabbit. Gauze patches were then placed over the treated areas and an impervious material was wrapped snugly around the trunks o f the animals to hold the patches in place. The wrapping was removed at the end o f the twenty-four hour period and the treated areas were examined. Readings were also made a fte r seventy-two hours. The Draize method of scoring was employed. Both s ite s (in ta c t and abraded) were examined dry as well as a fte r treatment with water. 0C0C8G 3M Company- - T^1325, Primary Skin Ir r it a t io n Study. Resui t s ; Concl us!on: See Table 1. Based on the accompanying tab le, the subject material would not be c la s s ifie d as a primary ir r it a n t to albino rabbits within the d e fin itio n of the Act-Reference: Section 1500.3 (c) (1) and requires no cautionary labeling with respect to that section. Karl L. G ab riel, V.M.D., Ph.D. Di rector 000087 M aterial: TABLE 1 Primary Skin Irrita tio n WET 3M Company - T-1395* as supplied. Reading Rabbi t Number Erythema and Eschar Formation (Hours) 1 2 3 k 5 6 Average Intact Skin Intact Skin Abraded Skin Abraded Skin 2k 0 0 0 0 0 0 0.00 72 0 0 0 0 0 0 0.00 2k 0 0 0 0 0 0 0.00 72 0 0 0 0 0 0 0.00 Subtotal 0.00 Edema Formation Intact Skin Intact Skin Abraded Skin Abraded Skin 2k 0 0 0 0 0 0 0.00 72 0 0 0 0 0 0 0.00 2k 0 0 0 0 0 0 0.00 72 0 0 0 0 0 0 0.00 Subtotal 0.00 Total 0.00 Primary Irrita tio n Score: o 000088 M aterial: TABLE 1 Primary Skin Irrita tio n DRY 3M Company - T-1395, as supplied. Erythema and Eschar Formation Reading (Hours) Rabbi t: Number 1 2 3 k 5 6 Average Intact Skin Intact Skin Abraded Skin Abraded Skin 2 k 0 0 0 0 0 0 0.00 72 0 0 0 0 0 0 0.00 2k 0 0 0 0 0 0 0.00 72 0 0 0 0 0 0 0.00 Subtotal 0.00 Edema Formation Intact Skin Intact Skin Abraded Skin Abraded Skin 2k 0 0 0 0 0 0 0.00 72 0 0 0 0 0 0 0.00 2k 0 0 0 0 0 0 0.00 72 0 0 0 0 0 0 0.00 Subtotal 0.00 Total 0.00 Primary Irrita tio n Score: 0 000089