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CENTRAL ANALYTICAL LABORATORY ( W X r b ' M R ep ort N o . ___----------------------------D a te ____ J l * y . A h . _1A 7.8. ..............
Subject: F C-143 Analysis of IRDC 137-090 Samples
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R eq u est N o . ___^6861(?______
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Report:
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Serum and livers from IRDC study 137- 090 (90 day subacute rhesus monkey toxicity with FC- 143) were received for analysis of FC-143 content.
Monkey
Dose
Survival
Serum PPm
Liver
Pm
Liver total
7362M 7386F
0 0
yes
- 0.05
3
yes
1 0.07
5
7364M 7366M
7384F 7385F
3 mg/kg/day
11
II It
yes yes
yes yes
53 3 48 -
65 7 50 -
250 -
350 -
7363M 7458M 7328F 7383F
7367M 7455M 7382F 7387F
10 mg/kg/day
1 II II
30 mg/kg/day
II
It II
yes yes yes yes
no yes no no
45 9 71 -
79 71 10
_ 125 145 60
- 80 - 125
600
-
--
750
8000 4000 7500 9000
7456M 100 mg/kg/day
7381F
O
M = male,
II
F = female
no no
- 100 - 325
6000 2000
001764
A .R. #b919
2 May 16, 1978
Although no effects (preliminary observation) were seen during the 90 day rat study at 10 - 1000 ppm FC-143, the monkeys at the higher dosage levels were adversely affected; however, the monkeys were studied at approximately 100 times greater concentration than the rats.
Note that both male and female monkeys accumulate FC-143 to about the same extent whereas with rats, only the male was found to contain high levels of FC-143. It is interesting to speculate regarding the conclusion of Prof. Singer's latest study with perfluorooctanoic acid. He used a female rat and found rapid excretion of the compound. Has he also studied a male rat to verify either his female study or would tiie results agree with the IRDC (137-089) study?
One obvious question, what is the difference in toxicity of octanoic acid, ammonium salt and FC-143?
/jz c :H.E. Freier
J.D. LaZerte B.W. Nippoldt R.A. Prokop F.A. bel D.G. Weiblen
201-1S 236-1 201-IS 236-3B 220-2E 201-1S
001765
