Document 6beXY1NoMJJGBOLQxvMeDxG1g

February 13, 1963 toxicity and safe hakdlinq op PYEftAUL A-200 Animal toxioifcy studies with this produofc have Indicated that the oral lethal dose (LPcn) to rats Is 10,500 milligrams per kilogram. The lethal dose when the material was applied un diluted to the unbroken skin of rabbitB is approximately 1250 milligrams per kilogram. ' We oonclude from the above that accidental ingestion on the part of humans is not a particular hazard in view of the high oral lethal dose In rats. Similarly, single massive skin exposures should not be immediately hazardous. The lethal dose obtained in skin penetration studies is such, however, that prolonged and repeated skin contact should be avoided because of possible systemic effects. In addition, prolonged and repeated skin eontaot may lead to skin irritation. We also feel that vapor inhalation should be avoided when the fluid is heated to elevated temperatures. Such exposure again relates to prolonged or repeated exposures rather than short term massive or acute exposures, in the case of the latter, workmen would not voluntarily expose themselves to concentra tions that are hazardous because of irritation of the respira tory tract. The use of Pydraul A-200 in industrial hydraulic fluid appli cations should not present toxicity hazards during the transfer of the fluid from original containers to the hydraulic system. Obviously when the fluid is within the hydraullo system, there should be no exposure and consequently, no hazard, in the event of rupture of hydraulic lines and subsequent splashing or spraying of the fluid on the heated surfaces, vapors of the fluid and possible decomposition products (depending on the temperature of the heated surface) may be irritating if inhaled to the degree that workmen will not voluntarily expose them selves to toxic concentrations. No hazardous exposure should result during the Interval required to shut down the system and obtain suitable respiratory protective devices during repairs to the system. The material in this report is to be used in development ol the product and may be given to responsible sales contacts, but it is not to be used by them in advertising copy. The source of this material is not to be divulged until it appears in formal publications. No exceptions to the established rule may be made without the approval of the Medical Depart ment in St Louis. Customers' inquiries regarding matters of toxicitv -are to be referred as before to the Medical Depart ment in St LouU for reply. -- Monsanto Chenv C DSW 009496 STLCOPCB4001219