Document 6bVpgOBZj56BjY5E9LL7OpjOd

Material Tested: Material Submitted by AR226-2748 Copies to: E. I. du Pont de Nemours and Company Haskell Laboratory for Toxicoljgy and Industrial Medicine HASKELL LABORATORY REPORT NO. 133-68 IPlastics Department 'Fluorocarbons Division ACUTE ORAL TEST Haskell No.: 5494 Other Code: Results: Solution % 15 15 10 3 3 1.5 1.5 1.0 1.0 0.5 0.1 0.1 0.1 0.1 0.05 0.05 0.01 0.01 Dose ma/ke 2250 670 450 300 200 130 90 60 40 26 17 12 7. 5. 3.' 2.: 1.! 1.1 Mortality* D 1 d. D 2 d. D 13 d. S 20 d. s 21 d. s 14 d. s 14 d. s 14 d. s 14 d. s 14 d. s 14 d. s 14 d. s 14 d. s 14 d. s 14 d. s 14 d. s 14 d. s 14 d. Toxic Signs Lethal Doses: at 670 mg/kg and above, chewing-motions, polyuria, and increased respiration rate; at 450 and 2250 mg/kg, slight salivation, all on the day of dosing; discomfort up to 12 days after dosing Nonlethal Doses: at 90 mg/kg and a above, discomfort for 3 to 21 days after dosing; at 60 mg/kg and above, small and irregularly-shaped feces for 1 to 21 days after dosing Controls Bodv 221 111 124 125 232 290 297 318 329 313 356 308 354 360 342 336 357 352-377 Liver - - 11.16 9.50 17.35 20.10 21.17 24.10 22.16 17.50 19.70 13.30 15.10 18.71 18.30 19.04 16.45 15 .09-18.89 * D - ( ) d. = FOUIld dead ( ) days after dosin^. S - ( ) d. - Sacrificed ( ) days after dosing. X .00 9.00 7.60 7.48 6.93 7.13 7.58 6.74 5.59 5.53 4.32 4.26 5.19 5.35 5.67 4.61 4.29-5.11 ALD 450 mg/kg r der^u!ly tOXiC fr the male rat When administered orally, its Approximate Lethal Dose (ALD) being 450 mg/kg of body weight. This compound appears to cause liver enlargement in rats with single doses as low as 12-26 mg/kg. Based on clinical signs, it also acts as a gastrointestinal irritant. SBF/jch Date: June 14. 1968 Company Sanitized. Does n0! contain TSCACBI