Document 6bVm5dja1NQ4KzrnoddypV0q1

Manufacturing Chemists Association Record of Meeting VINYL CHLORIDE TECHNICAL PANEL VINYL CHLORIDE RESEARCH COORDINATORS VINYL CHLORIDE MEDICAL SUBCOMMITTEE University of Louisville Louisville, Kentucky June 14, 1978 Dr. T. R. Torkelson, Panel Chairman, presided and opened the meeting at 8:35 a.m. Th following members and guests were present: MEMBERS PRESENT T. R. Torkelson W. D. Harris M. N. Johnson R. B* Judge C. D. Kary R. W. Laundrie R. W. McBurney R. A. Park (a) R. N. Wheeler The Dow Chemical Company Uniroyal Chemical Co., Division of UNIROYAL, Inc. The BFGoodrich Company, Chemical Division W. R. Grace & Co. Shell Oil Company The General Tire & Rubber Company Diamond Shamrock Corporation Firestone Plastics Company Union Carbide Corporation J. T. Seawell MCA Staff (a) For R. S. Brookman MEMBERS ABSENT R. J. Abramowitz L. H. Ballou 2. G. Bell, Jr. C. U. Demehl J. D. Dougherty B. W. Duck D. P. Duffield CONFIDENTIAL Suti.fent to Protective Or^er in _Ross_ v. Conoco . Inc , , To . r 0 - 1337 14th Judicial Pistr1 ' ~''-"*t Calcasieu Parish, Loiujiana Hooker Chemicals & Plastics Corporation The Firestone Tire and Rubber Company PPG Industries, Inc. Union Carbide Corporation Allied Chemical Corporation British Petroleum Co. Ltd. Imperial Chemical Industries Limited CMA 016078 -2- MEMBERS ABSENT (r^-mtinuedl R. E. Eckardt A. w. Fuhrman r. L. Gibson R. T. Gottesman J. G. Heil C. A. Johnson F. Kennedy S K. Law A. B. Lindquist R. L. O'Connell G. Roush H. A. Russell H. L. Schmidt W. M. Smith G. Ter Haar H. M. Zimmerman Exxon Corporation Great American Chemical Corporation Gulf Oil Corporation Tenneco Chemicals, Inc. Certain-Teed Products Corporation The Goodyear Tire & Rubber Company Continental Oil Company Keysor-Century Corporation Stauffer Chemical Company Olin Corporation Monsanto Company The Pantasote Company Borden Chemical Division of Borden, Inc. Air Products and Chemicals, Inc. Ethyl Corporation Georgia-Pacific corporation PRESENT BY INVITATION G. Barrows w. M. Busey A. Chang J. L. Creech K. Curran A. Davis B. De Rosa E. Drake J. Du E. Espinosa R. C. Feldhoff M. Fisher H. P. Fortwengler B. Gray J. T. Joseph C. E. Kupchello C. Moore K. O'Connell J. Sandoz C. R. Schrodt E. Scskas U. N. Streips University of Louisville Experimental Pathology Laboratories, Inc. University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville CONFIDENTIAL Subject to Protective Order in ss v. Conoco. Inc., No. 90-4837 14th Judici l TUstr-'ot Court Calcasieu Parish, Louisiana CMA 016079 -3- PRESENT BY INVITATION (Continued) C. H. Tamburro W. J. Waddell R. Warrick J. L. Wong p. Zurich University of Louisville University of Louisville University of Louisville University of Louisville University of Louisville * 1.0 Introductory Comments by the Chairman of the Vinyl Chloride (VC) Technical Panel. Dr. T. R. Torkelson Dr. Torkelson emphasized the importance and timeliness of a research review, the need of Panel members and members of the Research Coordinators as well as members of the VC Medical Subcom mittee to have an opportunity to establish raport with researchers at the School of Medicine, University of Louisville; and, the further need of VC Panel members to secure an insight into the 1979-1980 proposed research program. Dr. Torkelson then turned the meeting over to Carlo H. Tamburro, M.D., Principal Investigator, School of Medicine, University of Louisville. 2.0 Overview of University of Louisville Multi-Disciplinary Approach to the Study of Chemical Carcinogenesis, Especially Chemical Monomers - Dr. Carlo H. Tamburro, Principal Investipator The Medical School, University of Louisville has developed a multi-disciplinary approach to the study of chemical carcinogenesis, especially chemical monomers. Vinyl Chloride was one of the first monomers under study. This study involved the combination of a cancer control program incorporating a prospective medical surveil lance system for identifying occupationally related chemical cancer with a clinical research group which worked closely with a medical surveillance program developing better techniques for detection and prevention. Basic research on the molecular structure and pathogenesis of carcinogens, especially chemical monomers, created the third link in the multi-disciplinary approach to the overall study of chemical carcinogenesis. The remainder of the research review was concerned with summations of studies which comprised components of the three major research parameters of the overall program. These parame ters are: HON? IPENTlAli CMA 016080 -4- I. xx. Cancer control program - Medical Surveillance Systems Applied Chemical Investigations -- Detection and Prevention Systems III. Basic Research - Pathogenesis of Carcinogens Reviews were presented on the following component studies: 3.0 Analysis and Synthesis of Chemicals and Their Use in Bioassays for the identification of Carcinogenic Potential 3.1 Chemical Systems of Detection of Vinyl Monomer Toxicity Dr. J. Wong 3.2 Reactivity of Chemicals and Their Metabolites in Various Bacterial Assays - Dr. U. N. Streips 4.0 Use of Biochemical Enzymatic Systems for Detection of Chemical Toxicity 4.1 The Characterization of Biochemical Enzymatic Changes Occurring with Prolonged Vinyl Chloride Exposure in Animal and Man - Dr. C. H. Tamburro, Dr. J. T. Du 4.2 Vinyl Chloride Oxidation and Detoxification - Dr. C. H. Tamburro, Dr. J. T. Du 5.0 Immunological and Histopathological Studies in Chemical Injury 5.1 Immunopathology of Vinyl Chloride-Induced Liver Angio sarcoma and Effects on Antigen Antibodies - Dr. E. Espinosa 5.2 Search for Evidence of Vinyl Chloride Induced Tumor Antigen - Dr. C. H. Tamburro, Dr. H. P. Fortwengler 5.3 HLA Frequencies in Vinyl Chloride Workers ~ Dr. C. H. Tamburro, Dr. H. P. Fortwengler 5.4 Evaluation of Immunocompetence of Humans Chronically Exposed to Vinyl Chloride - Dr. C. H. Tamburro, Dr. H. P. Fortwengler 5.5 Tissue and Urinary Glycosaminoglycans in Hepatic Fibrosis and Hepatic Cancer - Dr. C. E. Kupchella Cl* 14081 BUfrfcyptj ,C(ftTCTCtSV Ins. , ivo. 90-4837 ~14jfeh "Judicj -'.l ristr'-'t '"ourt Calcasieu Parish, Louisiana -5- 5.6 Hepatic Cell Identification Technique - Dr. C. H. Tamburro, Dr. H. P. Fortwengler 5.7 Medical Surveillance System for Industrial Environments Dr. C. H. Tamburro 5.8 Bioassay of Chemical Monomers in Isolated Mammalian Liver Cells - Dr. R. C. Feldhoff 6.0 Preparation of Abstracts on Component Studies Drs. Tamburro and O'Connell have promised the Project Manager that complete abstracts will be prepared on all component studies. When available, these abstracts will be sent to Panel members of sponsoring companies. JTS:pmt Record Subject to Approval July 20, 1978 J. T. Seawell Project Manager vinyl Chloride Research 14th Julie Parish, Louisiana Calcasieu CHA 016082