Document 6b8oeNmxG9bKb8775eNeMnee6

Industrial Hygiene Dleeat - 0 Auguu:.. i.9n9 .I 9**3 Tcme of the Peripheral Vessels In Carton Monoxide Poisoning. L. Bluet and H. Borstein. Ccmpt. rend, aoc. Biol. "m?, (Iglifl) French. li. - Ob', ill:-::cu vi~h carbon monoxide the Hood vessels of the leg, vlth serves Intact, ahov narked vasoconstriction of central origin, folloved By1 vasodilation Just Before death. Hie vessels of the deserveted leg ahcrv qhly a vasodilation of hunoral origin. -- Chen. Abate, 9***s Bvpei 1-to.ta*. Research on the Toxicity of the Aliphatic Hltrlle; BC-(CH). -CS, 0,. Vereoa. Med, d. Lavorc. jg. 27^231 (Sept.- Oct. 194b) ItallAn. Tala research vas undertaken after clinical.and hematological studies ____ bad Indicated that vorkers lr. factories manufacturing nylon shoved anemia cf hoic,lytic type, positive indirect van den Burgh react lane, an Increase of llllxubln In the plasma, and other eigne of poisoning. The experiment or, guinea pigs, to determine Both acute and chronic toxicity, shoved that the aliphatic nitrile may affect the various organa By processes of con gestion. and degeneration; in the circulating Blood hyperchrOafc anemia of hemolytic type, leueopenla and monocytosis are produced. The results confirm the oBeervatlcr.fi made on the Blood changea found I* nylon vorkers, -- Condensed from Bull. Hyg. [ ' ; i' 9*<5 Toxicity of Thloacetamlde In Bats. A.M. Ambrose. 7. Be Bds and I.J. Bather. J. Ind.'BygTOox'. 1, 158-l6l (May, 19**9). Boses of thloacetamlde up to and Including 100 mg. per kg. adminis tered to rats By stomach tube appeared to Be non-toxic. Death folloved doaee of 200 mg/kg. or more. Male rats shoved no 111 effects of diets containing 0.001 to 0.032$ thloacetamlde over a period of 190 days, but toxic effects and early death occurred vhen the diets contained 0.06b to 0.128$ of thloacetamlde. In the latter cases, cirrhosis of the liver occurred. -- Authors' Summary and Conclusions 1> ) 9b6 Changes In the Blood Follovlng Exposure to Gaseous Ammonia. F.C. Schmidt and Boris C. Vallsacourt. Science 553-556 (Nov. 19, 1948), Bisks of Inhaling fumes of ammonia may arise from leaks or during the transfer of ammonia. Such Inhalation may result In Initial exhilara tion and Increased frequency of respiration, folloved By exhaustion several hours later. Studies arc reported In vhlch air containing a constant concentration of ammonia varylng'loos than 30 p.p.m. vas breathed over four hours. Blood samples vere analyzed at regular Intervals. The non-protein nitrogen In the Blood and amnonla varied regularly vlth time; But the urea and creatinine content shoved no variation. The pulae rate vas constant, But the Blood pressure dropped after the first 33 minutes of Inhalation. The authors consider that the absorption of ammonia By the blood Is a chemical process, not a physical one; It seems to Be a second-order reaction. -- Bull. Hyg. -v l. J It * f I I 4