Document 6Ry3X4gOLbkNjLq7jE9D1Bkxg

Fab-10-97 02:29P Huntingdon Life Sciancas P . Ol Huntingdon Lift Srimeet lac., PO Box 2360, Media* Bond. Last Millstone, Nj 08X73.2360 USA Tclepltow: (90*) 873-2330 Fax: (908) 873-1992 Huntingdon Life Sciences TOTAL NUMBER OF PAGES INCLUDING THIS PAGE: 5 If this transmission is unsatisfactory please contact us by telephone at (908) 8732550 ATTENTION OF: Dr. James B. Knaak FROM; R. E. Schroeder COMPANY: Occidental Chemical Corporation DATE: 10 February 1997 FAX NUMBER. 972-404-3285 cc. Dr. H. Shah CMA 703-741-6091 MESSAGE: 96^4080, Vinyl Chloride Combined Inhalation Two-generation Reproduction and Developmental Toxicity Study in CD rats Daily chamber exposure data through Week 4. Dear Dr. Knaak, Attached are daily chamber exposure data for the referenced study. The bolded numbers on 30 January arc the GC values. The next interval for the GC/IR comparative evaluations is this week, If you have any comments or questions concerning this format please call me or Gary Hoffman. Regards, & Raymond EC:l Sc chroeder Study Director CONFIDENTIALITY NOTICE: This fox iruiMiiiM'Mt mnv ^mlivldntial mftHiwUiw tlinl i* legally tbv u* ni'thf recipient named If you received \\i\t, fux in effwr. p\*ttw nou\\ u irnmcdbUlv by copying, diklrthtMjon or oUitr um of (he uanwiuded inloi'tiutiutu t rfiriwlly prohibited. The iiiibniMiioii w intended only fur Y*u m umitioned \\\n\ any disviuaurc, F e b -1 0 -9 7 O Z : 3QP H u n tin g d o n L it e S c ie n c e s P .Q 2 Vinyl Chloride Combined inhalation Two-Generation Reproduction 96-4080 _________ and Developmental Toxicity7 Study in CD Rats__________ Chamber Monitoring Results Cumulative Exposure Record Croup 1 - 0 ppm_______ Particle Size Week Date Exposure Mirau (IR)* Determinations Number Mean Individual mmad GSD TMC 1 7-Jan-97 8-Jan-97 9-Jan-97 1 2 3 (Ppm) 0.0 0.0 041.88 0.0 0.0 0.0 fc 00 0.0 00/1.2 (PPm)_______________________________(ptn) 0.0 0.0 0.0 0.0 0.0 00 o.o 0.0 3.114 0.0 t 0.0 * 0 0/1.2 o.o/o.o (rag/tn'} 1.714 0.000541 KWan-97 4 0.0 0.0 00 0.0 00 00 0.0 13-Jan-97 2 14-Jaa-97 l5-Jan-97 5 6 7 00 0.0 0.0 0.0 0.0 0.0 0.0 00 0.0 00 0.0 0.0 0.0 0.0 0.0 oo 00 0.0 0.0 00 oo 1 812 2.271 0.001290 16-Jan-97 8 0.0 0.0 00 0.0 0.0 0.0 00 17-Jaa-97 9 0i/0.099 0 a/0.593 * 00/0.0 00/8.0* 0.0/0.8 O.OAP.O 00/0.8 20-Jan-97 10 0.0 0.0 00 0.0 0.0 0.0 0.0 3 21-Jan-97 22-Jan-97 23-Jan-97 11 12 13 0.0 0.0 00 0.0 00 0.0 0.0 oo 0.0 oo 0.0 f f r 3.798 2.192 0.002000 04) 0.0/0.0 00/0.0 0 0/8.1 00/0.0 00/0,0 o.o/o.o 24-Jan-97 14 0.0 0.0 0.0 0.0 00 00 00 27-Jau-97 IS 0.0 0.0 0.0 o.o 00 00 00 4 28-Jan-97 16 0.0 0.0 0.0 0.0 0.0 0.0 0.0 29-Jan-97 30-Jan-97 17 18 00 0.0 00 0.0 0.0 0.0 0.0 7.101 2.014 0.001190 0/0 0/0.0 0/8.0 0/0.8 0/8.0 0/8.0 0/8.0 31-Jan-97 19 0.0 0.0 00 0.0 0.0 0.0 00 J-Feb-97 20 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Mean: 0.0 (L4I f 0.14 4 3.956 2.048 0.801255 SD: 0.0 0.0 0,37 2.253 - 0.808597 `Botdvdues Indicate GC confirmation of tie 1R sample Chamber Environment Mean Temperature Humidity rej 22 <%) 41 22 39 23 42 22 49 23 48 22 41 22 40 23 53 22 42 22 39 22 38 23 40 23 42 22 34 22 34 22 45 21 34 20 32 20 37 21 40 22 43 15 ` Due to equpment problems GC sample was not taken ` Mean and SD of ai individual R samples. ' Mean and SD of at Indmdual GC samples. * Samples taken before the sample lute leak was repaired 'Due to equipment problems Mran sample was riot taken. o > CD CD -fc. 1 0 -9 7 0 2 i3 0 P H u n tin g d o n L if o S c ie n c a s Vinyl Chloride Combined Inhalation Two-Generation Reproduction and Developmental Tenacity Study in CD Rats 96-4080 Chamber Monitoring Results Cumulative Exposure Record Group 11 -10 ppm Week Date Exposure Number Nominal Mean 1 7-1an-97 8-Jan-97 9-Jan-97 10-Jan-97 1 2 3 4 (ppm) 9.8 98 98 9.8 (ppm) 10 9.7 9.S/14 10 13-Jan-97 2 14-Jan-97 !5-/an-97 16-Jan-97 n-lan-97 20-Jan-97 3 21-Ian-97 22-Jan-97 23-Jan-97 24-Jan-97 27-Jan-97 4 2S-Jan-97 29-Jan-97 30-Jan-97 31-Jan-97 3-Feb-97 5 6 7 8 9 10 11 12 13 14 IS 16 17 18 19 20 9.8 10 98 9.7 98 10 9.8 10 94 9.5/7.6 9.8 10 97 12 98 12 98 11/14 9.8 11 9.8 10 98 11 98 11 9.8 11/12 9.8 11 98 11 Mean: SD: 9.8 #.l 1 041 * Bold values indicate GC oonCrmation of Bw IR sample 1 Due to equipment problems GC sample was rat taken. Chamber Concentration Miran (IR>* Individual _______ _iPPnQ___________________________________ ________ 11 11 11 9.9 9.1 8.2 9.2 9.8 9.7 11 90 94 9.4 ^ 9.3/14 9 2/13 9 7/14 10/13 92/14 9.3 9 9 9.4 11 II 10 10 )0 10 10 10 11 9.3 99 10 10 96 96 11 99 10 10 10 10 96 il 10 10 10 10 7.2/0.95 * 8 0/2.7' 11/2.9 * 11/13 10/12 10/14 11 11 97 10 10 11 12 11 12 10 13 12 10 14 11 fI 12/14 li/14 11/14 11/13 11/13 11/13 11 11 11 n II 11 88 11 11 10 11 11 10 11 n 11 11 11 11 H n 10 10 10 11/11 12/13 11/13 11/13 11/10 10/12 11 11 11 11 11 11 9.6 12 11 11 11 11 10 * 12 4 0.9 3.9 Particle Size Chamber Environment Determi natrons Mean MMAD GSD TMC Temperature Humiditv (tun) (mg/m5) <C) (%) 21 42 1755 1.887 0.000221 22 42 22 42 22 42 22 42 2.152 2 555 0.001290 22 22 42 42 22 42 22 42 22 33 1 654 2049 0.001310 24 22 33 41 25 42 25 35 24 36 1616 1.647 0.000172 24 25 45 35 24 35 27 29 25 38 1.794 0.246 2.035 - 0.000748 03100637 23 2 39 4 ` Mean and SD at al indkfdusl IR samples * Mean and SD of al jndmdual GC samples * Samples laken before the sample tme leak was repaired 1 One to equipment problems lAran sample was nrt taken o > 00 U 00 a lL to :F a b - l O - 9 7 O Z 3 0 P H u n t i n g d o n L l f a S c i e n c e s CMA 118843 Vinyl Chlonde Combined Inhalation Two-Generation Reproduction 96-4080 and Developmental Tonicity Study in CD Rats Chanber Monitoring Resalts Cumulative Closure Record Group in - 100 ppm Week Date Eqomt Namher Nominal Mean 1 7-Jan-97 8-Jan-97 9-Jan-97 lO-Jan-97 13-Jan-97 2 14-Jan-97 [5-Jan-97 16-Jait-97 17-Jan-97 20-Jan-97 3 21-Jan-97 22-Jan-97 23-Jan-97 24-Jan-97 27-Jan-97 4 28-Jan-97 29-Jan-97 30-Jan-97 31-Jan-97 3-Feb-97 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 (PP) 94 94 94 94 94 94 94 94 95 94 94 94 94 94 94 94 94 94 94 94 (PPm) 97 100 991110 9* lift no 98 96 100/63 100 110 HO 110/100 99 100 99 100 110/130 100 100 Mean: SD: 94 0.2 102 5J * Bold valuer indicate GC confirmation ol the R sample ' Due to equpmert problems GC sample was not taken. Chamber Concentration Miran (IR)* Individual (ppnt) 95 95 100 96 94 100 99 lift 100 no 100 100 99" 96/111 100/110 100/110 100/110 100/120 97 97 99 95 100 100 no 110 no 97 100 no no 100 100 no 110 HO 93 94 93 110 100 100 94 93 96 96 98 96 110/50 ` 90/90' 110/93' 93/0.0 ' 100/37 * 100/110 100 100 110 HO 100 100 100 no 110 100 110 110 no no 110 r too 100 110/120 100/75* 100/65* 110/120 110/120 110/120 100 98 100 99 100 93 100 100 100 100 100 100 too 100 100 97 100 98 100 100 100 100 99 100 110/140 100/120 110/130 110/130 110/130 100/130 110 100 100 100 100 too 100 100 no 100 100 too 102 r 102 4 5.4 35 Particle Size Chamber Envirnnmeiit Determination! Mean MMAD GSD TMC TeiriDerature Hunuditv (fim) 7.015 2.056 0.001060 ro 21 20 20 (%) 40 40 41 21 42 22 48 23 40 3.727 2.495 0.001940 22 39 23 57 22 40 22 40 1.356 1.487 0.001480 20 21 20 39 43 46 20 44 20 42 3.273 1856 0.000427 20 21 20 47 44 45 20 44 21 44 3.843 1.974 0.001227 21 43 2.351 - 0.000643 1 4 ' Mean and SO of al individual IH samples. * Mean and SD of al individual GC samples * Samples taken before the sample bne leak was repared ' Due to equipment problems Miran sample was not taken 1 Samples taken bejore a leak in one fitting was discovered and repaired "0 O P F e b -1 0 -9 7 0 2 :30P H u n tin g d o n L if a S c io n c a s Vinv) Chloride Combined Inhalation Two-Generation Reproduction 5)6-4080 and Developmental Toxicity Study in CD Rats Chamber Monitoring Results Cureillative Exposure Record Group IV - I 100 ppm Chamber Concentration Particle Size Chamber Environmen: Week Date Exposure Miran (1R)* Determinations Mean Number Nominal Mein Individual MMAD GSD TMC Temnerature Humiditv (ppmi (ppm) (ppm) (am) (tnc/m3) <C) <%) 1 7-Jan-97 8-Jan-97 1 2 1100 1100 1100 1100 1200 1100 1100 1100 1100 1200 1100 1200 1100 noo ll) noo 1.544 1.357 0.000227 20 20 45 45 9-Jan-97 3 1100 1200/1100 110U* 1200/1200 1100/760 1200/1200 1200/1100 1100/1200 20 45 IO-Jan-97 4 1100 1100 1100 1100 1100 1100 1100 1100 20 45 13-Jan-97 5 1100 1100 1200 1200 1100 NOO 1IOO 1100 20 46 2 t4-Jan-97 15-Jan-97 16-Jan-97 6 ? 8 1100 1100 1100 1100 1100 1100 1100 1100 1100 1100 1100 1100 1100 (100 1100 1100 NOO 1100 1200 1100 noo 1100 1100 1100 1127 1.345 0.0007C5 20 20 20 45 39 42 17-Jan-97 9 1100 1200/1300 i 100/890 ` 1100/1300 1300/1400 1200/1300 1200/1400 1200/1300 20 42 20-Jan-97 3 2 l-Jan-97 22-Jan-97 23-Jan-97 24-Jan-97 27-Jan-97 4 28-Jan-97 29-Jan-97 10 11 12 13 14 15 16 17 1100 1100 1)00 1100 1100 1100 1100 1100 1200 1200 1200 1200 1200 1100 1200 1100 1100 1100 noo 1200 1200 1100 1100 1100 1100 1100 noo 1200 HOC 1100/1300 120Q/14M 1100/1300 1100/1300 1100/i30o! 1100/1300 1100/1300 11G0 1100 1100 1100 1100 noo 1100 1)00 1)00 noo 1100 1100 1100 HOO 1100 1100 1100 1100 noo 1100 tioo 1100 1100 1100 1100 noo noo 1100 1.404 1.325 1.837 0.001790 1 336 0 000237 21 20 21 21 20 20 21 21 43 42 48 52 47 47 53 47 30-Jan-97 It 1100 1100/1400 1100/150 1100/14001 1200/1500 1100/1400 1100/1400 1100/1400 20 53 31-Jan-97 1 1100 1100 HOO 1100 1100 1100 1100 1100 21 49 3-Feb-97 20 Mean: 1100 1100 1100 ms 1100 1100 1100 1122 c 1100 1200 ms * 1200 1.375 1.469 0.000740 21 2ft 49 46 SD: ft 37 43 ITS 0.134 - 0.00*735 0 4 * Bold values inicate GC oonlkroaionof tie IR sample * Due to equipment problems GC sample was not taken ` Mean and SO of al ndvidual tR sarwples 1 Mean and SO ofal indindual GC samples * Samples taken before Ihe sample line leak was repaired oo > GO CO 00 GO -fc. -ctns -ts