Document 6Rp6N0xrXDYy3dGaYL3wgrdyg

Monsanto f,QM ,.. loot,ON, w< Rt Richard - Research Center AtI March 10, 1969 AtflMNCI w .NOTES ON MEETING 5/6/69 ; crp TTTKTSTHIal BIo-TEst Laboratories, inc, T TSHHAgCfrI/gsnR"_ uWtITLD.nUrrTnFpET TO PILE . i- l Those present: H. Bergen/D. Olson P. Benignus/j. Bryant J. Fallon/D. Roush/ S. Shaw J. Springste/Schalk/ Waychoff R. Keller/E. Tucker C. Payton/K. Welle B. Wlldl Joe Calandra - Pres.-Chemist PhD and M.D, + Staff Northwestern U-Pathology Otis Fancher - V. Pres.-Chemist PhD + Drug Research M. L. Keplinger-(Kep) PhD Biological evaluation ' Ray Kary - Air Pollution - Rad. Health * Lawrence Beer- Environmental Services ' Monitor chemical plants - Nuclear Power Plants , E. Wheeler and W. Richard reviewed background on Aroclor proper ties, recent analytical results by Scott Tucker, history of Aroclor, application uses, ref. to Risebrough's Dec. 1968 paper in Nature; effects by public relations, legal and scientific findings on Aroclor and its products. We discussed amount ..of material-15000 lb/yr, passing through Santa Clara warehouse, questioned whether PCB could really be present to affect wildlife as reported in Risebrough's paper on San Francisco Bay. We asked for consideration of problem from public relations, DDT Wisconsin hearings, legal actions, and scientific aspects. We dis cussed problem from: " ' . Analytical chemistry Acute and chronic toxioity - animal-fishbird studies Enzyme enhancer calcium metabolism - thin egg shells ' hormones * human involvement Terrestial ecology The last subject, ecology, was Just mentioned because Bill Johnson, Bio-Test man in this field, was at U. of Wisconsin. The name of Dr. Thomas Parks, U. of Chicago, was mentioned as a possible con sultant - may be retired. Logistics of Aroclor exposure and likeli hood of contamination not discussed enough. stv. M et MAE 053277 WATER PCB-SD0000016816 -2 - The question of a grant to Newall - at Stanford, was mentioned. Possible listening post for West Coast activities. - No decision. The problem of contacting and maintaining contact with the Univer sity and Qovt. people who are seeking biological information on PCB's was discussed. Names of Bill Johnson and perhaps Lawrence Beer were mentioned. We discussed possible consultants who might be of help on this problem. , Monsanto Consultants Alan Mehler Robert Metcalf Bert Vallae Jean Mayer Marquette U - blochem and enzymes U. of Illinois-entomologist Harvard - enzymes Harvard - nutrition Possible Bio-Test Consultants 4 Wayland Jack Hayes Vanderbilt Thomas Parks U. of Chicago - ecologist-Dept, of Biology Agreed to convene at earliest possible date at either Bio-Test or Monsanto with appropriate consultants. Job of educating Monsanto consultants, and getting permission, to fall to E. Wheeler and W. Richard, (March 21 tentative date) Bio-Test consultants Job to J. Calandra - Otis Fancher. E. Wheeler will report on program to date: I. II. III. Rat tissue residue study and acute levels for Aroclor 1242, 1254, 1260 and 5460. Chicken tissue residue study and acute levels. Fish toxicity TLM. IV. Chicken toxicity - reproductive egg and meat residue (6 months) To go ahead with study but add enzyme and hormone experiments plus calcium metabolism studies and egg shell thickness. V. Mallard Duck - (Aquatic Bird) - Same type study as for chickens. VI. Threa generation reproduction in rats (18 months). Start now. . VII. TWO year study In rate (26 months) Start now. VIII. Two year study in dogs (26 months). . IX. Subacute Fish Study. Start Immediately. Consider possibility of reproductive cycle. X. Metabolic studies No decision, question on need for radio tracers. Seem inclined to do without radio tracers. MAE 053278 WATER PCB-SD0000016817 Francis T. Mayo 3en'\ Frlend Lawrence Beer. Chief Federal Water jPollu ( Regional Enforcement Offi San Francisco District Discussed requirements of sampling fish and water in San Francisco Bay, location of a lot of Risebrough's accusations vs. PCB and' possible site of very low Aroclor usage. L, Beer indicated 40,000 for this kind of Job. Wheeler and Richard said 4,000 plus a rowboat. Defense seems to have these elements. I. Aroclor not intended to be spread around. Used in closed systems, recycle of material, limited exposure. - most but not all Aroclor uses meet the above description. II. Aroclor identification in nature. Is it really identified? Is it a metabolic product of something else like 2-4d or 2,4,5T or chlorophenols? For example, hard to see that 15,000 lb/year could pollute San Francisco Bay even if were all dumped in. III. Atmosphere and streams around our mfg. plants and major customers. Need to establish a norm and an acceptable standard. IV. Establishing a tolerable limit. Here the Wisconsin EDF type will want 0 tolerance. They will be driving on this subject as they are against DDT. Even.-if they fail, they will drive people from product use. This is already happening with DDT because of public relations aspect. V. Not discussed but possibly obvious. Can we find out whether product degrades in nature so that it does not accumulate? Only real way out long term. Joe Calandra again mentioned need for soil and bug experi ments so that PCB1s could be shown to degrade. If . Aroclor is an enzyme enhancer, does that mean enzymes attaok It? This program is not in gear. ms Att. 1 , &/C. W. R. Richard MAE 0532.79 WATER PCB-SD0000016818