Document 6Rd91oQNj5OnaXVKv89LG8Ykm

March 5,2007 Via Electronic and U.S. Mail Richard Irons, PhD, DABT Principal Investigator, Shanghai Health Study University of Colorado Health Sciences Center 4200 East 9th Avenue, C238 Denver, CO 80262 Ralph J Altiere, PhD Dean, School of Pharmacy University of Colorado Health Sciences Center 4200 East 9th Avenue, C238 Denver, CO 80262 Re: The Shanghai Health Study Dear Drs. Irons and Altiere: We are writing on behalf of the the scientific and clinical research being We appreciate Dr. Shanghai and (API) in support of '-HH"HE:,uU~ Health Study. unique project in worthy effort. to continue the study ~HHHH.LHVLH" from the five members of lltlOnal conditions of the study being independent Quality metrics and milestones for progress and Shanghai Health Study Proposed Budget INU.Ul'-'U November 10, 2006, submitted by Dr. Irons of ",'.HHVHLU funding up to $6,559,864 has been agreed to. This (as described in the referenced request): Plan A Study ~V.LHIJH., (Tables I and 2) $5,759,864 Plan B Laboratory ition Personnel Proposed Budget (From Table 3) $400,000 Post Study Costs for continued publication of study findings $400,000 TOTAL $6.559.864 Formal authorization and disbursement of these additional monies is contingent upon successful execution of an agreement between API and the research entity that will be continuing the study. SHELL-MCCLURG-065130 Given the urgency to execute a grant/contract to continue the study, API looks forward to receiving a proposal in the near future to extend the existing grant or to establish a new contract with the University of Colorado, CynPathogen, Inc. or another entity. API Exhibits A-I to A-III, Proposal Guide For Prospective Contractors are attached; the information requested therein is necessary for the establishment of the new commitment. Sincerely, Red Cavaney Cc: C. Klaus D. Ross D. Wilkerson SHELL-MCCLURG-065131