Document 6RRQ8deM189d1JBDK1jzbeeyE

M6_ I- 28 000235 DuPont Company Chambers Works PFOA in Blood -^ Chambers Works PFOA Recycle ntaawwasslPffdshauoaeannsoerbaoemvmtriddttausoeorePbn1kprp2c3rrr1eFe9aetall04ti0eoi9rotOnls0nros0srn9eady0g.AsrewolmpeuyatiwbwaTpaafsnhbpprlrbtb4haldootyrsley-l.2isii.oyrunsa2waascdwPlpg0WlqosocoahF0msuoncoonbuyiO0oorangndfologkrnduebnAtturkniehrtllaeelbceaiirdoeintftwdstrecnooieobseePtwvwrardadedwyliFtsosanoeoimcsOalhnhbdgrorvioetaokogeoAle2cmcdetrncndtva0eoaoroRepbmioc0stnwtdloa.eotele0lcepurreeviDtrceedtyowanicnyahnnduittluicgtheetgautPnhtrlshnedinoaeaoceicmresnatthianepte,irnlghPomadetyrtitheonnFcnazhg1fpecsyynOcibo9aeanelcas9allroiuAgeseollgs9tcesydffsweebn.f,hsrttepsleslihebreidottccrnoceiShassoaotne3ymthsiaalcCdvgce0comnlceaeeallhwsishipitnvlpn1naanosieeeee0lmbcmeggmeoadsl0lrrssbnuspbppaari.plddlwsetrlepooeeipotreBsohsifosesbcdutfnytrlsfdreWf.hloeooootswssessouAmpsartuoada.in<ecnWpmtrlnrohtdlak1mAphadlnpso0aotteyeaohtlo0sfsrlserzrnehorteaoadtsepschiictormldtn,puwitseooipgrmg.bnspanoreesieti.lsndnbarorBenedaeamwconsgrcatlbh,ocitashWpohiba1youespolnn9ulletnttcoillhsui9hstneedcorer9iecsekisbnetoonts1gldelacfoat9brdnufohbooo9odcuaoud9rttlthenpdd rTaenhloiiasthbelexerpmdearetitaehnaoctdethtlheeadltoDwwuoPlueolvdnetblsteoimnwwoorrhekicswehniwtshietaivwdeeiafrfenedirneptnertorecvsoitdneedtr.amcot raensaclyietinctaiflilcaablloyraatcocruyroatne and J) December 9,2004 Barbara J. Dawson, C1H, CSP 000236 DATA SUMMARY Chemical: Perfluorooctanoic Acid Site: Chambers Works, Deepwater, NJ Date o f Monitoring: September - October 2002 Matrix: Blood Serum Operation: PFOA Recycle Jab Title Entire Cohort Males Females Operators Males Females Mechanics Males Females Laboratorians Males Females Supervision Males Females Number ,.Sampled-' 62 61 1 17 17 0 18 18 0 21 21 0 6 5 1 # o f Samples <LOQ (50 ppb). 21 21 0 0 0 - 3 3 - 15 15 - 3 3 0 - Minimum'. TConcentration '(ppb)- bs*s 50 50 57.6 52.7 52.7 59.8 59.8 . 50 50 . 57.6 106 57.6 Mean 172 173 57.6 373 373 168 168 35 35 92 98.8 57.6 Median" >: .M axim um -*. Standard ;:vg i | p b ^ 4 y ^ li^ B tra tro ih V . Deviation i r 'i *-44(PPM-NMEmAV-. 78.8 1650 286 78,8 1650 288 57.6 57.6 0 175 1650 461 175 1650 461 . -- 122 658 156 122 658 156 -- <50 88.5 17 <50 88.5 17 -- -5 4 313 113 <50 313 57.6 57,6 0 C om m ents; Samples analyzed by Advion Laboratories using LC/MS/MS Means and standard deviations were calculated using 25 ppb {1/2 of the LOQ) for those samples reported as less than the LOQ. 000237 Prepared by: Barbara J. Dawson, CIH, CSP Date of Preparation: November 17, 2004 DuPont Company PFOA in Blood Chambers Works September - October 2002 Analyte Biological Subject Concentration Concentration M atrix (jig/m l) Units Job 1lb PFOA Serum s i || 57178 0.168 ug/ml A ssignm ent Operator PFOA Serum 57179 0.175 ug/ml Operator PFOA Serum 57180 0.0788 ug/mi Operator PFOA Serum 57181 1.65 MQ/ml Operator PFOA Serum 57187 1.13 Ug/ml Operator PFOA Serum 57188 1.11 ug/ml Operator PFOA Serum 57198 0.0978 M9/ml Operator PFOA Serum 57199 0.347 ug/ml Operator PFOA Serum 57201 0.0834 Ug/ml Operator PFOA Serum 57202 0.277 ug/ml Operator PFOA Serum 57204 0.297 ug/ml Operator PFOA Serum 57205 0.233 ug/ml Operator PFOA Serum 57206 0.0527 ug/ml Operator PFOA Serum 57207 0.174 ug/ml Operator PFOA Serum 57208 0.125 ug/ml Operator PFOA Serum 57211 0.210 ug/mi Operator PFOA Serum 57200 0.127 ug/ml Operator AVG 0.388 STDEV 0.472 MIN 0.053 MAX 1.650 MEDIAN M liit -- i-- 0.193 PFOA Serum 57182 ^ ^ " ^ 0 0 2 5 ug/ml JL Technician PFOA Serum 57183 0.025 ug/mi JL Technician PFOA Serum 57184 0.025 ug/ml JL Technician PFOA Serum 57185 0.0561 ug/ml JL Technician PFOA Serum 57186 0.025 ug/mi JL Technician PFOA Serum 57189 0.025 ug/ml JL Technician PFOA Serum 57190 0.025 ug/ml JL Technician PFOA Serum 57191 0.025 ug/ml JL Technician PFOA Serum 57192 0.025 ug/ml JL Technician PFOA Serum 57193 0.025 ug/ml JL Technician PFOA Serum 57194 0.025 ug/ml JL Technician PFOA Serum 57195 0.05 ug/mi JL Technician PFOA Serum 57196 0.0543 ug/ml JL Technician PFOA Serum 57197 0.025 ug/mi JL Technician PFOA Serum 57203 0.0506 ug/mi JL Technician PFOA Serum 57209 0.025 ug/ml JL Technician PFOA Serum ;57210 0.0565 ug/ml JL Technician PFOA Serum 57212 0.025 ug/ml JL Technician PFOA Serum 57213 0.025 ug/mi JL Technician PFOA Serum 98049 0.025 ug/mi JL Technician PFOA Serum 98134 0.0885 us./TM1 ...... JL Technician fo r results less than lim it o f quantitation (0 .0 5 0 ug/m i), one half o f the LO Q is used fo r statistical analysis (0 .0 2 5 ug/m l) Prepared by Barbara J. Dawson, CIH, CSP November 17, 2004 000238 DuPont Company PFOA in Blood Chambers Works September - October 2002 Analyte Biological M atrix Subject Concentration Concentration (|ig/m l) Units Job A ssig n m en t AVG STDEV MIN MAX MEDIAN PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum AVG STDEV MIN MAX MEDIAN HHHNH " 57214 57215 57216 98039 98041 98047 98048 98056 98135 98136 98137 98138 98139 98140 98141 98142 98143 98040 0 .5 3 0.017 0.025 0.089 0.025 M9/ml 0.0910 ug/ml 0.0750 U9/mI _ 0.025 tig/ml 0.244 Mg/ml 0.0598 ug/ml 0.137 ug/ml 0.199 ug/ml 0.242 ug/ml 0.226 ug/mi 0.359 ug/ml 0.122 ug/ml 0.0629 ug/mi 0.025 ug/ml 0.127 ug/ml 0.264 ug/ml 0.0807 ug/ml 0.025 ug/ml 0.168 0.156 0.025 0.658 0.125 Mechanic Electrician Mechanic Mechanic Mechanic Mechanic Mechanic Lagger Inst. Mechanic Mechanic Mechanic Mechanic Electrician Inst. Mechanic Mechanic Mechanic Mechanic Mechanic PFOA PFOA Serum Serum 98009 ^ 98010_ <LLQ l ........... BLANK <LLQ ug/mi BLANK PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum PFOA Serum AVG STDEV MIN MAX MEDIAN 98055 98133 98144 98145 98146 98147 0.106 ug/mi 0.025 ug/ml 0.025 ug/ml 0.025 ug/mi 0.0576 ug/ml 0.313 ug/ml 0.092 0.113 0.025 0.313 0.0413 1st line super Engineer Chemist Area Mgr ATO Unit Tech Ldr fo r results less than lim it o f quantitation (0 .0 5 0 ug/m l), one h alf o f the LO Q is used fo r statistical analysis (0 .0 2 5 ug/m l) Prepared by Barbara J. Dawson, CIH, CSP November 17, 2004 000239  fi Chemical: PFOA DATA SUMMARY Site: Chambers Works Date o f Monitoring: 2004 Matrix: Human Blood Serum Operation: Secure Environmental Treatment Job Title Entire Cohort Males Females Operators Mates Females Mechanics Males Femates Laboratorlans Males Females Supervision Males Females Num b*- , Sampled 29 29 0 to 10 0 19 19 0 0 0 0 0 0 0 Minimum 1331 13.3 . 15.7 15,7 13.3 13.3 - - - - - Mean 46.48 46.48 70.31 70.31 33.94 33.94 - - - - - - Median | J | 37.9 37.9 71.8 71.8 - 36.1 36.1 - - - - . - - 174 174 174 174 65.55 65.55 - - - - - Comments: Analysis by Exygen Where duplicate samples were run, averages of two were used for statistical analysis Descriptive statistics calculated using Microsoft Excel j/--j. 36.05 36.05 . 51.53 51.53 14.59 14.59 - - - 000240 Prepared by: Barbara J. Dawson, CIH, CSP Date of Preparation: December 9, 2004 ^ j i g :-i; ) DuPont Company PFOA in Blood Chambers Works 2004 Secure Environmental Treatment Operator Mechanic 65.8 26.55 132 36.1 174 55.8 20.6 16.9 15.7 22.75 80.8 65.55 80 23.4 22.7 22.85 77.8 33.6 33.7 47.4 46.1 37.9 43.3 13.3 40.3 42.35 16,3 38.9 15.5 Count Min Avg Median Max Std Dev 10 15.70 70.31 71.80 174.00 51.53 19 13-30 33.94 36.10 65.55 14.59 Count Min Avg Median Max Std Dev AH 65.8 132 174 20.6 15.7 80.8 80 22.7 77.8 33.7 26.55 36.1 55.8 16.9 22.75 65.55 23.4 22.85 33.6 47.4 46.1 37.9 43.3 13.3 40.3 42.35 16.3 38-9 15.5 29 13.30 46.48 37.90 174.00 36.05 December 9,2004 Barbara J. Dawson, CIH, CSP 000241 ) DATA SUMMARY Chemical; PFOA Site: Chambers Works Date o f Monitoring: 2004 Matrix: Human Blood Srum Operation: Non-PFOA/Non-Telomers Job Title , ' si --- Entire Cohort Males Females Operators Males Females Mechanics Males Females Laboratorians Males Females Supervision Males Females Number - Minimum . Sampled 8 5.55 8 5.55 0- 6 5.55 6 5.55 0- 2 13.2 2 13.2 000- 00- 00- Mean'-'i 14.97 14.97 14.91 14.91 - 15.15 15.15 - - - - - ^Medi^n7->"j ^ M t im u m 'r^ ';^ Stapdar.d- 11.3 .11.3 10.15 10.15 - 15.15 15.15 - -/- - - - 43.2 43.2 . 43.20 43.20 - 17.1 17.1 - - 11.92 11.92 14.05 14.05 - 2.76 2.76 - - - - - Comments: Analysis by Exygen Where duplicate samples were run, averages of two were used for statistical analysis Descriptive statistics calculated using Microsoft Excel Prepared by: Barbara J. Dawson, GIH, CSP Date o f Preparation: December 9,2004 000242 DuPont Company PFOA in Blood Chambers Works 2004 Non-PFOA/Non-Telomers Count M in Avg Median Max Std Dev Operator Mechanic 12.3 13.2 43.2 17.1 5.55 8.11 10.3 10 62 5.55 13.20 14.91 15.15 10.15 15.15 43.20 17.10 14.05 2.76 All 12.3 43.2 5.55 8.11 10.3 10 13.2 17.1 8 Count 5.55 Min 14.97 Avg 11.30 Median 43.20 Max 1192 Std Dev Prepared December 9,2004 Barbara J. Dawson, CIH, CSP 000243 ) DATA SUMMARY Chemical: PROA Site: Chambers Works Date o f Monitoring: 2004 Matrix: Human Blood Srum Operation: Former PFOA Recycle Operations Job Title . Entire Cohort Maies Females Operators Males Females Mechanics Males Females Laboratorians Males Females Supervision Males Females Number .. Minimum - | | Mean. C oncentration, 23 17.2 241.3 23 17.2 241.3 0- - 15 37,9 330.05 15 37,9 330.05 0- - 8 17.2 74.89 8 17,2 74.89 0- - 0- - 0- - 0- - 0- - 0- - 0- - M e d ia n jjjg ! M a x im u ^ p Standard,' C o n c e n tra tio n `f f M a t io # , 95.7 1605 387.3 95.7 - 1605 - 387.3 - 170 1605 458.39 170 1605 458.39 - -- 59.3 59,3 - - 163 51.63 163 51.63 -- -- -- - - - -- -- - - -- Comments: Analysis by Exygen Where duplicate samples were run, averages of two were used for statistical analysis Descriptive statistics calculated using Microsoft Excel Prepared by: Barbara J. Dawson, CiH, CSP Date of Preparation: December s, 2004 000244 DuPont Company PFO in Blood Chambers Works 2004 Former PFOA Recycle Operation Count Min Avg Median Max Std Dev Operators Mechanics Male Male 412 72.2 84.3 46.4 174 163 95.7 44.4 77.4 73.8 1605 142.5 53.4 39.6 241 17.2 188 56.6 37.9 1200 170 441 114.5 15 8 37.90 17.20 330.05 74.89 170.00 59.30 1605.00 163.00 458.39 51.63 All 412 84.3 174 95.7 774 1605 53.4 241 188 56.6 37.9 1200 170 441 114.5 72.2 46.4 163 444 73.8 142.5 39.6 17.2 23 Count 17.20 Min 241.30 Avg 95.70 Median 1605.00 Max 387.30 Std Dev Prepared December 9, 204 Barbara J. Dawson, CIH, CSP 000245 DATA SUMMARY Chemical: PFOA Site: Chambers Works Date of Monitoring: 2004 Matrix: Human Blood Serum Operation: Controls Job Title Number liliiaBsMiMjMliaa Entire Cohort -n Males 10 Females 3 Operators 0 Males 0 Females 0 Mechanics 0 Males 0 Females 0 Laboratorlans 0 Males 0 Females 0 Supervision 0 Males 0 Females 0 Minimum -V-V Mean Concentra tie n i 'm B S i m 3.66 7.73 3.66 8,32 3.92 5.77 -- -- -- -. --. -* - ---- -- Median 7.55 7.98 5.76 * - - - .f p i i i S ^oncerttratfB rll 13.95 1342 13.95 3.63 7.62 1.85 .- ._ --- -* . -- -- -- -- -- Comments: Analysis by Exygen Where duplicate samples were run, averages of two were used for statistical analysis Descriptive statistics calculated using Microsoft Excel 000246 Prepared by: Barbara J. Dawson, CIH, CSP Date o f Preparation: December 9, 2004 DuPont Company PFOA in Blood Chambers Works 2004 Controls Count Min Avg Median Max Std Dev Male 7.55 9.59 4.82 13.95 8.41 5.72 3.66 4.88 12.6 12 10 3.66 8.32 7.98 13.95 3.63 Female 7.62 5.76 392 3 3.92 5.77 5.76 7.62 1.85 All Controls 7.55 9.59 4.82 13.95 8.41 5.72 3.66 4.88 12.6 12 7.62 5.76 3.92 13 Count 3.66 Min 7.73 Avg 7.55 Median 13.95 Max 3.42 Std Dev Prepared December s, 2004 Barbara J. Dawson, CIH, CSP 000247 __ ) DATA SUMMARY Chemical: PFOA Site: Chambers Works Date of Monitoring: 2004 Matrix: Human Blood Serum Operation: Jackson Laboratory Job Title Number Entire Cohort Males Females Operators Males Females Mechanics Males Females Laboratorians Males Females Supervision Males Females 12 10 2 0 0 0 0 0 6 6 0 6 4 2 Minimum .C o n c e n tra tio n . 5.5 7.16 5.5 . - - - - - 7.16 7.16 - 5.5 11.5 5.5 M ean. *.:; Median 18.27 20.23 8.5 - . - - - 24.35 24.35 12.2 14.05 8.5 12.95 15,8 8.5 . - - - 18.05 18.05 11.85 12.95 8.5 67.8 67.8 11.5 * - - - 67.8 67.8 - 18.8 18.8 11,5 Comments: Analysis by Exygen Where duplicate samples were run, averages of two were used for statistical analysis Descriptive statistics calculated using Microsoft Excel Deviation 16.75 17.76 4.24 . - - - . 22.59 22.59 4.28 3.5 4.24 Prepared by: Barbara J. Dawson, CIH, CSP Date o f Preparation: December 9,2004 000248 DuPont Company PFOA in Blood Chambers Works 2004 Jackson Laboratory Count Min Avg Median Max Std Dev te c h n ic ia n M ale 7.63 17.9 18.2 27.4 7.16 67.8 6 7.16 24.35 18.05 67.80 22.59 Supervision Male Female 18.8 5.5 12.2 11.5 13.7 11.5 4 11.50 14.05 12.95 18.80 3.30 2 5.50 8.50 8.50 11.50 4.24 Count Min Avg Median Max Std Dev All All Male A ll Sup 7.63 7.63 18.8 17,9 17.9 12.2 18.2 18.2 13.7 27.4 27.4 11.5 7.16 7.16 5.5 67.8 67.8 11.5 18.8 18.8 12.2 12-2 13.7 13.7 11.5 11.5 5.5 11.5 12 10 6 5.50 7.16 5.50 18.27 20.23 12.20 12.95 15.80 11.85 67.80 67.80 18.80 16.75 17.76 4.28 Prepared December 9, 2004 Barbara J. Dawson, CIH, CSP 000249