Document 6REyQ8Xmr10enXJa03O1kGOyR

JCIATED ETHYL COMPANY LIMITED MEDICAL SERVICES 2 0 BERKELEY SQUARE, LO N D O N , W. I j ROSVENOR 6030 HIL1P BOYD / MedicalOfficer T E L E G R A M S : ETHYLPORT, WESDO. LONDON C A B L E S : ETHYLPORT. LONDON O UR REF. / YO U R REE. Apr i l 2k, 1956. Dr . R. A. Kehoe, Ket t er i ng Labor at or y of Appl i ed Physi ol ogy, Uni ver si t y of Ci nci nnat i , Col l ege of Medi ci ne, Eden Avenue, CI NCI NNATI 19, Ohi o, U. S. . A. Dear Dr . Kehoe, . I n a r ecent per sonal l et t er t o Fr ank Pr i nci , I happened t o ment i on t hat I was i nt er est ed i n f at t y sal t s of l ead, and he suggest ed I shoul d wr i t e t o Dr . St evens. Thi s I have done, and encl ose a copy of my second l et t er , whi ch i s r eal l y par t of t he f i r st , as i t has occur r ed t o me t hat per haps you woul d pr ef er t o know of t hi s cor r espondence. The pr obl em i s t hat I have been asked by cer t ai n aut hor i t i es i n t hi s count r y t o hel p t hem wi t h t he quest i on of t he t oxi ci t y of t he f at t y sal t s of l ead, and I f i nd i t di f f i cul t t o get any aut hor i t at i ve i nf or mat i on on t hi s subj ect i n t hi s count r y. Fr ank suggest ed I wr i t e t o St evens, as he appar ent l y i s wor ki ng i n t hi s f i el d, but I t hi nk you shoul d know of my- enqui r y. Ther e i s anot her poi nt i n whi ch I am par t i cul ar l y i nt er est ed at t he pr esent t i me. Thi s r el at es t o t he r api d scr eeni ng t est f or l ead i n ur i ne. I n 1953 Chol ak wr ot e an ar t i cl e i n t he Ar chi ves of I ndust r i al Hygi ene and Occupat i onal Medi ci ne, suggest i ng an i mpr ovement i n t he met hod t o i dent i f y t he or gani c compounds of l ead whi ch mi ght exi st i n t he ur i ne i n t he t et r aet hyl l ead i ndust r y, al ongsi de wi t h t he i oni c l ead whi ch i s al one pi cked up by t he or di nar y shor t met hod of anal ysi s. The suggest i on was t o add i odi ne t o conver t t he or gani c l ead t o i nor gani c l ead bef or e cont i nui ng t he nor mal st ages of t he met hod. Whi l e our chemi st s have not yet publ i shed t hei r f i ndi ngs, t hey have exami ned t he whol e t echni que, and gone one f ur t her by r ecover i ng t he f i nal l ead and r e- assessi ng i t . I t i s t hei r pr esent opi ni on t hat t he Hi 0010217 N29799 .ri- bHifib clCAU o , Kehoe. 2f.IY.56. l0<oa0u) - 2 - ext r a col our whi ch i s pr oduced by t he addi t i on of i odi ne i s not whol l y due t o t he conver si on of or gani c l ead t o i nor gani c but al so possi bl y t o an act ual col our change caused by t he use of i odi ne, and t hat t her ef or e t he f i nal f i gur e wi t h t he new t echni que does not t r ul y r epr esent t he l ead cont ent of t he ur i ne. Pr obabl y I shoul d have wai t ed t o di scuss t hi s wi t h you unt i l I coul d l et you have t he r epor t on t hi s, but I t hought i t mi ght be i nt er est i ng at t hi s st age t o hear whet her i n f act si mi l ar comment s on t he t echni que have been voi ced bef or e' . I n t f yi s mat t er , I woul d be most gr at ef ul f or your comment s, as we ar e havi ng t o r e- assess t he var i ous scr eeni ng met hods we use i n t er ms of t hei r val ue and t hei r avai l abi l i t y i n t he pr act i cal ci r cumst ances of t he f act or y r out i ne. I shal l not di st ur b you l onger wi t h t hi s l et t er , but send you my ver y war mest r egar ds. Your s si ncer el y, PRB/ j mr K 0010318