Document 6R47eDRmQvJQdNK4bdNv2NaJE
H
i I
I
PLAINTIFF'S EXHIBIT DUP-1325
\
E. ! ou Pont oe Ncmouhs & Commni WiuminOTON. Oclawahc ttl
'.ICI ikO
OCTwfMT
CtCMCa 0vif<0
A. J. H03XAX EASKSLA ua.
April 3. 1973
vss^zzk:* zyjSAXX&LiSL *s*zsr<x
The attached tibiae are froa a report by Or. W. X. Saith of tha Raalth Rcaaarch tnatitute at rairleigh Oiclcinaon. Ha do not have tha full report but preauae that it le available if you viah to order it.
ZEStpe
i. c. mu, jit.
eerrea >
RECEIVED
*?R 1 1 IS -2
HASKELL LABORATORY
K'i4G I
DUP 0903156
12&970
DU 024538
7 vz-zor^t Co-nssny me CSC
\\
------------- v,, ,
----- J
-%e N.-.v vor* NY10C17 . (212: eSo-SSo -
A -tsz
TALC ANO THE AS8ESTOS DUST STANDARDS
DUP 0903X57
r*t ff* 'r9Mf.ll tm ft ** 9* 9* ****-44 4*4 *|ftf vt* *KI
W * "** **99w*'*9 9* *9* fkW*0m*9Ht4 *: "
'
120971
DU 024539
/ \
Exhibit 1
Pose ^ - /52
-ASIgyrOS" MINERALS AS LISTED IN PtPERAL KEGISTEK
Ajboitot or FibrojaVorio^ Quyootilo -- Crecidoliro Affloiito
C) (. ) (>
OjornicolComooiition Mf3(Si205) (OH)4 No^OjFojCSIjO^) (OH)2 (M8,eo)7(s;|o22) (oh)2 (Ma,Eo)7(S5j022) (OM,F)2 Ca2Mflj(S;,022) (OHjEJj
(OH,F)2
Non-A*|foj 0f Noiv^JbOu_Vori^ Anfigorif#, Uzardlr* Rloboeklro Cutnmingtonf f Anthophyllifo Tromolito ActlnoHto
DUP 0903158 120972
DU 024540
Exhibit I
Pace ? -/?</
Th# source of tha data on the following pages, 3 and 4, Is:
TERMINAL PROGRESS REPORT: GRANT NO. 3R01 EC-00226-04S1
TITLE: MESOTHELIOMA IN RELATION TO ASIESTOS
PERIOD: 03/01/66 - 01/31/70
Principal Investigator: William E. Smith, M.D. Haalth Rtsaareh irutitute Feirleigh Dickinson Univanlty Madison, N.J. 07940
Tha atm of this project was to tat 23 preparations of asbestos or other minerals
for carcinogenicity by means of intrapleural injections into hamsters. Each sample
vms tasted in 9roup mf 50 hamsters.
DUP 090U59 120973
DU 024541
Tafal l. FINDINGS IN HAMSTERS AFTER INTRAPLEURAL INJECTION SO hamiten per group
(Cumulative data to 650 day* except where noted)
SAMPLE
Groua No. 1. Soft
Chryiotile
Mean Fiber Length micron*
32.54
Doit Meiothelioma
mg.
25 8
Sarcoma Injection Site
2
Lymphoid Turnon
1
Remark*
2. Horih Chryiotile
38.85 25
9
3
1
3. Soft Chry*. (hooted)
32.54
25
10
0
0
4. Soft Chryiotile
.76 25
0
0
2 700 days
S. Honh Chryiotile
6. Soft Chryt. (heated)
7. Honh Chryiotile
8. Honh Chryiotile
1 25 (approx.)
1 25 (approx.)
38.85 10
38.15
1
0 0 4 0
1 1 1 1
3 700 days 0 700 day* 1 0 ' 700 days
9. Amsiito
t7
10. Amojite
17
11. Serpentine Reek Quit (Antigarite)
to 3 10
25 l
2 0 0
0 0 0 700 deyt
12. Micecovert* 54.7 Fihen
10
4
1
3
13. Nemollte
53.1
25
0
0
2 OUP 090316
12097
DU 024542
jaMiaMaPiiBaBawiMii
K
'OS# 4
Exhibit 3
Tab!# 1 (continued) FINOINGS IN HAMSTERS AFTER INTRAPLEURAL INJECTION 50 hamster# oer grouo
(Cumulative dcta to 650 soy# except where noted)
SAMPLE Greuo No.
Mean Fiber Length microns
Dost mg.
toma
Sarcoma Injection Site
Lymphoid Tumor*
14. Tremolite Tate
15. Diatomaceeue Earth
25 0 25 3
0 2
0 700 days 2
ISA. Diatomaceeue Earth (Calcined)
25 4
2
1
16. Plberglan with 24.9 Phonal Formal Under
10
0
0
5
17. Nickel Powder 1
It. Crocidolita Id. CrocIdol tte
UICC UICC
10 10
1
4 10 2
4 5 0
0 1 4 700 days
20. Anthophyllite 21. Anthophyllite 22. Glass Fibeti
Long (UICC) Short (3.7) 16.9
10 10 10
3 1 0
0 0 0
2 0 5
23. Untreated 24. Untreated
non* non*
0 0
0 0
0 700 dey*
4 660 day* (sunrivors are being followed to 700 deiys)
DUP 0903161 l2**75
DU 024543
v*
\4
=5.T :orz4'
any pc 33
=--~--- ------...... ?i = -.e-ue ''.e'-v vsn< r\j v "CO
TALC AND THE ASBESTOS DUSTS T A N D A R D S
.nr wxt ow/ ^i:*r i t tt<3 ve;.'
.#s w :
*<? mo. eim*?** * * <,, j **m . DUP 09031.62
DU 024544
cxnibi^ 1
"AS8ESTOS" MINERALS AS LISTED IN FEDERAL REGISTER
Ajb*ifo or Fibroul Variety Chrysofil* Crocidolif# Amo tite
() () ()
Chamieol ComoojiHon ^3<s;205> (CH)4 Na2^*3^*2^!322^ H)j (Mfl,F>)7(Si3022) (OH>2 (Mg,F*)7(S;s022) (OH,F), Ca2Mg5(Si8022} (OH,F)2 Ca2(Mg,Fo)5(Si8022) (OH,F)2
Non-Asbtitos or Non--Frbrous Variety Anfigorite, LIzardire Riebccklr* Camming torn'( Ant+ioehylllf*
Tramolita Acflnolif*
DUP 0903163
DU 024545
( Exhibi f 3
The source of the dots on the following pages, 3 and 4, is: TERMINAL PROGRESS REPORT: GRANT NO. 3R0I EC-00226-04S1 TITLE: MESOTHELIOMA IN RELATION TO ASBESTOS PERIOD: 03/01/66 - 08/31/70 Principal l.-.vestigator: Willicm E. Smith, M.D. Health Research Institute Fairleigh Dickinson University Madison, N.J. 07940 The aim of this prefect was to test 23 preparations of asbestos or other minerals
for carcinogenicity by means of intrapleural injections into hamsters. Each samole was tested in a group of 50 hamsters.
DUP 0903164
DU 024546
cxhibif 3
Table I .
FINDINGS IN HAMSTERS AFTE3 INTRAPLEURAL INJECTION 50 hcmsrers per group
(Cumulative acta fa 650 coys except where noted)
SAMPLE
Grouo No. 1. Soft
Chrysotile
Mean Fiber Length microns
Dote Mesothel ioma
mg.
32.54 25
8
Sarcsmo Injection Site
2
lymphoid
2. Harsh Chrysofile
38.85
25
9
3
3. Soft Chrys. (heated)
32.54
25
10
0
4. Soft Chrysotile
.76 25
0
0
5. Harsh Chrysofi le
6. Soft Oirys. (heated)
7. Harsh Chrysotile
8. Harsh Chrysotile
1 25 (approx.)
l 25 (approx.)
38.85 10
38.85
1
0 0 4 0
I ! i
i
1 0 700 dcys
9. Amosife
17
10. Amosite
17
11. Serpentine Rock Dust (Antigorite)
10 3 10
25 1
2 0 0
0 0 0 700 days
12. Microquartz 56.7 Fibers
10
4
1
13. Nemolite
53.1
25
0
0
DUP 0903165
DU 024547
/' \
Exrioit 8
Tcbie
FINDINGS IN HAMSTERS AFTER INTRAPLEURAL INJEClCN 50 namsrets ser grouo
(Cumulative aata to 50 ficys exceof where noted '
SAMPLE GrouD No.
Meen Fiber Length mieronj
Dose mg.
Mesothel ioma
Ssresma Injection Site
Lymoncid Tumors
14. Tremolite Tale
15. Diatamaceous Earth
25 0 25 3
0 2
0 700 cays 2
15A. Diaromaeeous Earth (Caiained)
25 4
2
1
16. Fiberglass with 24.9 Phenoi Formal Binder
10
0
0
5
17., Nickel Powder 8
10
4
4
0
18. Cracidolite UICC
10
10
5
1
19. Crocidolite UICC
20. Anrhcphyltite 21. Anthophyllite 22. Glass Fibers
Long (UICC) Short (3.7)
16.9
1 10 10 10
2 3 1 0
0 0 0 0
4 7C0 dcvs 2 0 5
23. Untreated
none
0
0
0 700 days
24. Untreated
none
0
0
4 660 davs (survivors are being fallowed i 7C0 dcys)
UP 0903166
DU 024548
i
.c'^c-'o-:Co-^2a,~y nc
:3C --C'. - ',-uri V.v vOTK Ni' :0*7 i*."2' c<53-632 / - v ?
TALC AND THE ASBESTOS OUST STANDARDS
r*t rt;*' *v*?ar** mr n * #* # .g .v t;*ef vf.R * ...#u u
DUP 0903157
>* % #* ##f |kvy* ia < : v
#
120971
DU 024549
Exhibit \
Oqc * z4 ^ 2
*A58E?TQS* MINERALS AS l.'STSP IN FcDESAL EESISTER
Ajbottoi or Fibrout Vortify OuytoHI* Croeidalir* Amoiilo
() () ()
Oumieol Csfflootirion M83(Si203) (OH)4 ^*2^*3^2^*3^22^ (OH)j CMg,F.)7(Si9022) (OH)2 (Ma,Fe)7(Si8022) (OH,F)2 Co2AA95(Sig022) (OH,F)2 C#2(M, F*)j(Sij022) (OH,F)2
r
Non-Aioitot or Non*Firoui Vsr'e'v A^figorito, Lizorsir*
Cummingtonift Anthophylllt* Trtfnollt# Acfinolif#
DUP 0903158 12*9?
DU 024550
Exhibit I The source of the date on the fallowing pages, 3 and 4, it:
TERMINAL PROGRESS REPORT: GRANT NO. GROT EC-0D226-04S1 TITLE: MESOTHELIOMA IN RELATION TO ASBESTOS PERIOD: 03/01/66 - 08/31/70 Prine`pol Investigator: William E. Smith, M.D.
Haelth Research Institute Fairleigh Dickinson University Mod lion, N.J. 07740 Th aim of thii project was to test 23 preparations of asbestos or ether mir.trelt for carcinogenicity by maont of introplourol injection) into homsters. Each sample wot tested in a group of 50 hamsters.
DUP 0903159
DU 024551
Exhibit I
Table 1. FINDINGS IN HAMSTERS AFTER INTRAPLEURAL INJECTION 50 hemjreri ser group
(Cumulative data to 650 days except where noted)
SAMPLE
Group No. 1. Soft
Chrytetfle
Mean Fiber Length microns
32.54
De Mejorhel loma
mg.
25 8
Sarcoma Injection Site
2
Lymphoid Tumori
I
Remoria
2. Horjh Chryiotile
38.85 25
7
3
1
3. Soft Chry*. Seated)
32.54
25
10
0
0
4. Soft Chryiotile
.76 25
0
0
2 700 days
5. Harth Chrysolite
4. S(HoftatCe4h)ry* -
7. Horjh Chryiotile
1 25 (approx.)
1 35
(opprox*)
38.85 to
0 0 4
1 1 1
3 700 doyt
0 700 doys
1
8. Harili Chryiotile
38.85
t
0
1
0 * 700 doyt
8. Amoiito
17
10. Amosite
17
11. Serpentine Rock Oust (Anfigorite)
10 3 10
25 t
2 0 0
0 0 0 700 deyt
12. Micrcpuertz 54.7 Fiber*
10
4
1
3
13. Ncmolite
53.1
25
0
0
2
DUP 0903170
129974
DU 024552
Exnib; f 8
Table I (continued) FINDINGS IN HAW STEFS AFTER INTRAPLEURAL INJECTION 30 hamjtarj sir grouo
(Cumulative beta to 65C sayt xetst wh.r. noted)
SAMPLE Group No.
Moan Fibor Length mieronj
Dot* mg.
Moioth.liomo
Sarcoma Injection SfU
Lymohoid Turnon
14. Tremolite Tale
23 0
0
0 70C 3Cy*
IS. Diatemaeeoue Earth
23 3
2
2
15A, Diafomoccoui Earth (Calcined)
25 4
2
1
16. Plberglaa with 24. f Phonal Formal einder
10
0
0
5
17. Niekel Powdor 8
10
A
4
0
18. Croeldolito UICC
19. Crectdolils UlCC
20. Anfhsphyllite 2). Anthophyllite 22. Gtais Fiber*
Long (UICC) Short (3.7)
16.9
10 l
10 10 10
10 2 3 1 0
5 0 0 0 0
1 4 700 days 2 0 5
23. Untreated 24. Unttaotad
non* non*
0 0
0 0
0 700 dayi
4 660 day. (jurvivon are bcNg fol!e*u to 700 dcyi)
I2&9?5 DUP 0903171
DU 024553
asta.
SX?CS'.~?S TC XS 2SSTTS svst
In ths
of pretseci.-.g the health of its enpl=yee*,
the Du Seat Company and your Plant Ranagenent have eetatlishet
an acceptable level i:r asbasecs exyesure. The recommendation
isr the acceptable level is based upsa the i--.dsrtatu.cn that
no health problems related te asbestta will result la aayc.-.e
who la exposed to this concentration for their working life
time. The reason this level has been made mandatory is natur
ally to protect the health of people who are occupationally
exposed to asbestos. I aa sure seme of you have seen
Or. Rubiah from Haskell Lab checking air samples around the
shop areas while you were doing your normal jobs. The pur-
pese for these air checks was to determine the ecnceneraeisr.s
o asbestos fibers in the air and to determine what changes
In jobs or ecuipaent were neeaaaary to gee and kaap tha air
levels of asbestos at a minimum and an acceptable level.
These changes probsbly have had seme effect upen the way in
which you perform yeur job, but they were done to protect
your health as wall as ehe health of yeur fallow employees-
Sew, we have talked about what yeur Plant Management
la delay to be sura that you have e place to work chat is
free from recognised hazards from asbestos. Efforts es
protect yeur health will be ineffective unless yeu try
te Minimise your own exposure eo asbestos. There ere
0U* 0903m-
120976
DU 024554
S Mj-Z
gxpcsvRj rc *s3sst=s :vst
(Continued)
several things you can do to protect yourself iron unaccept able exposure to Asbestos dust.
1.) Fellow established standard practices for handling asbestos. 2.} Step seeking if yeu do; don't start if you don't. Zn ay opinion, it has been conclusively proven that cigarette smoking is a cause of irritation to the lungs and bronchial tubes and can cause cancer of the lungs and ehronie bronchitis and emphysema without any other factors being present.
Significant asbestos exposure also has its primary effect en the lunge, as we will discuss
farther, so he use of cigarettes and their
effects ca the lunge could compound any problem that developed. 3.) YOu should wash your hands, arms, and faee/ befora eating to prevent the inhalation of dust that sight bo on yeu. 4.) to not eat la shop area where asbeates duet accumulates. 9.) Clean off loose duet from clothing before leaving the plant..
-2----------------------
DUP 0903173
----------
1 29977
DU 024555
S.EATX \
cxscsv^r ?c ^satercs ru*? (Continued)
*.) Use and wear all personal protective equip ment provided you.
Coitpany standards and protective equipment provided by the Coapaay and designed to protect you from asbestosis and other complications are only as effective as your willingness to do everythin? possible to protect yourself.
Asbestos has been known to aan sines the stone agts, having been used to sake pottery. The ten asbestos eoaes froa the Greek word that means inextinguishable or unquench able and is a ten that embraces a number of fibrous silicate inertla found throughout tthe*wcrld. Thera are 3 aajor types of asbestos* the type being deeeniaed by the fiber length end physical properties. Crysotile asbestos accounts for 95% of the asbestos production end is the type Best used in the United States. Croeldolite end Aaoaite ere the other ewe amjer types. Asbestos is the only mineral that can be woven into doth. Ccnerieal mining of asbestos began in the late 1*701s and it is sstiaaesd that there era about 3000 different industrial applications for asbestos in the United States today. This ranges from insulation matsrial tm brska shoes, in ceaent, floor til^ end many other uses.
Sow let's talk a few minutes about asbestosis. The recognition of asbestosis as a disease goes beek to the first century when the Greek Geographer, Strabo, and the Xcoan
DU? 09031"4
128978
DU 024556
2SAS2
fX?CSvns TC XSBESTCS tts? (Continued)
Saturalist, PHnaf the Eldar, each
a s icier.* i ;;
the lungs 1a ilavt whesa occupation was to vaava asbestos
iaao eieth. The cloth ae that tine was usad In ertnatior.
and was described as the "funeral drass of kings*. Very
little constructive aedical information was obtained er
pursued about asbastasls following ibis. Tba modem know
ledge of asbastosis datas to about 1900 whan Sr. a. Montagus
Murray of London daseribsd tha fibrosis of asbastosis in tha
lungs of a can who had worked la tha carding rooa of a fac
tory for 14 years. A few years later, an inspector in tha
Dapartaaat of Labor of England, daseribad tha illness in a
group of aoployaas in an asbestos weaving sill. This was
tha first report of the epideaiology of asbastosis.
Ssfareuuuiy, neither he nor Sr. huny realised the full
significance of their finding*. The first written report
of tho illness in the modem aadical literature was in
1924, when D*. W. E. Cooke, an teglish physician, described
a ease in a woman who daveloped symptom after working for
13 years in an asbestos textile sill, as was also first to doscribo the difference beeween asbastosis and ether
pnauaoeonioaes.
Beeween 1921 and 1929, Or. E.B.A. Merewether examined
313 asbestae-textile workers and found that slightly oars
than 23% shewed evidence of pulmonary fibrosis with symptom.
DUP 0903175
- 129979
DU 024557
' *AX
txgcsvyx A2~sr: r.~?
(Continued)
H tlis shewed that th i_-.cidar.ct :i fibre*!* mere*sad direct proportion to th nuabar cd years cf exposure, reach ing SIX in tha group od wotkari employed in th industry dec 20 yaars os ssro. Za 1931, as a result ed this study. Great Britain passed regulations to eentrol tha dust and exposures better thaa had been dene previously. This was the dirst tine that attaapts were aade to eontrel the exposure ed huaaas to asbestos dust.
On a survey in 1949 in South Africa, a larger slain? area dor asbestos, an Anerican physician found ehildrsn developing asbsstosis bsdors fha ays ef 12. Zn Chechin? on their activity, he found that they were eapleyed in a aill and their job wee to stand in large jute bags and pack the asbestos fiber down with their feet as ths aatsrial was being put into the bag.
Za 1M0, 2 physieians working independently, one in finland, and one in South Africa, discovered asbestos bodies in the lungs of people who lived near asbestos factories but 14 aot work in thea. This was ths first indication that asbestos could be inhaled without direct eeeupatieaal exposure. Huy studies have been done sinee this to sub* staatiata tha prevalence ef asbestos fibers in the ataesphare.
-3. ---------- ------------ ---- _ -
DUP 09 C 3 * l 20980
DU 024558
U2
x?cs-Ttr re asitstts
(Cor.zLr.~mi)
There La still much work being dsn* on asbestcs exposure ar.d esbestosls ar.d such work sui.ll n*ds us b* den*. Medical authorities and industry *r* becoming mere eenceroed ever xpour* to *sbsta<; and better protection and precautions are being developed.
The exaee mechanism of asbestosis ie unknown, but we believe that asbeetc* fibers are inhaled and become trapped in the snail air sacs of the lungs. Because of the movement of the bronchial tubes with breathing, the fibers work into the lining of the bronchial tubes. They ereate a chronic irritation here and the body tries to' get rid of the irrita tion and deposits various materials around the fiber eo make it less Irritating and to try to absorb it. The body mechaalsas are not ablo to raaovo the fibers so the conglomerate of asbestos fibers and defense mechanisms sake up an asbestos body. The chronic irritation to the lung continues end c.tce the asbestos body is deposited, it is always prasent. Because of the chronic irritation, eeazring and sear tissue develop in the lung and reduce the lung's ability te move air. Shis makes the lung ne longer effective as a means of exchanging oxygon; and then ehronie lung disease called asbestocia develops. This usually first shows up as short ness of breath, k dry cough then develops and than production of blood-streaked sputum. An occasional inhaled fiber will not cause significant scarring in the lunga te interfere with their function, but constant inhalation of large numbers
...
---
oup 0903177
i 20981
DU 024559
g.Kg.
Pg.CSVitS " A33SSTCS STS? (Continued)
of fibers weuld; and that is the basis fcr the permissible air concentration being established. Asbestesis does .-.ci predispose semeene to tuberculosis as does siiieosis and amthracosis.
Calculations suggest that asbestos workers who sacks have about 90 times the risk of develop lag lung complica tions drea asbestes exposure as do man who neither sacks aor work with asbestos. This is tha reason fer recommend ing stepping smoking if you do, don't start smoking if you don't.
Z think that with the prograa tha Company and your Plant Management have started, and with your cooperation and help, there should not he any health hazards related to asbestos through your working lifetime.
Bruce W. Karxh, M.D. April 4, 1973
BNX/bjd
7
DU? 0903118
129982
DU 024560