Document 6Boajx7mRzNZQr820x70Z3X76

UNION INTERNAL CORRESPONDENCEr CARBIDE UNION CARBIDE PLASTICS COMPANY RECEIVED* DEC--3-ragt n)U]nn;t nano* a foxicMon nAng RIVER ROAD, BOUNO BROOK, NEW JERSEY Ta (Noma) Dr. A, W. DOWneS Company ** {Jnion Carbide Corporation New York 17, New York December 1, 1964 oR & D Division 13 3-^ Copy k. Dr. C. U. Dernehl - NY Mr. P. H. Hunter - BB Mr. N. H. Reinking - BB Dr. H. F. Smyth. Jr. - Mellon Mr. R. L. Wechsler - BB Organotin Stabilizers for PVC Bottles You have asked for a summary of the current status of PVC stabilizers under consideration for molded vinyl shampoo bottles. This is as follows. 1. Stanclere 80, 176, and 386, said to be di-n-octyl tin compounds by Pure Chemicals Ltd We have asked Pure Chemicals for toxicity data and chemical identity to be sent to Dr. Smyth. They have passed this request to Chas. Pfizer & Co. who are their U.S. licensee. 2, Chas. Pfizer has not contacted us regarding food additive status. They are having a difficult time providing suitable samples for use evaluation 3. T-831 by Metal & Thermit Chemicals. Dr. Ken Bank of M & T is a persona] friend of Dr. Dernehl and has given him the formu lation of T-831 and all available toxiticity data. 4. Advastab T-270 by Advance Chemical. This is identified as dioctvltin 3-mercaptopropionate. Advance has given us elaborate extraction data in oil as well as in the usual aqueous simulated food solvents which show maximum extraction of 2. 4 microgram/ square inch of tin. We understand that this work was done as part of a food additives petition but FDA is now not favorably ' inclined toward a tolerance for general food packaging uses and hence Advance does not plan to pursue this course further. How ever, the data may well be adequate to support our shampoo bottle usage. UCC 063582 To: Dr. A. W. Downes -2- December 1, 1964 * Subj' Organotin Stabilizers for PVC Bottles_________ *_ . ,1^ 5. "Dorlil" stabilizer in the Lesieur PVC bottle. Ken Morgareidge of F & D Research Labs has been retained by Doflil to expedite their food additive clearance. Morgareidge tells us that FDA will accept 90 day feeding studies because the stabilizer is somewhat innocuous and believes that within a year it will be covered by a food additive regulation. He thinks it could be used now for a shampoo on the basis of no adulteration. We understand that studies on the effectiveness of these materials as stabilizers in PVC bottles have not yet been completed. piA' > ' W. B. Ackart WBA:rmr v. V - ucc 063583