Document 6BREoDNw93M5MJw0X4gqnwJmE

DAT* j * April 241 1979 ... a QSA - -AGENT 'ORANGE * ftCFCRENCC 1 TO ; ! 0 R. Bishop - A3NB G- Biggins - G4NG ^0 J. McCarville - A3NC J. W. Molloy - 1740 G. Roush - A2SA J. J. Spano - G4NH In response to your early April request r.a QSK is attached for use per Dr- McCarville's memo.of 4/24/79. The one word insert in question two and the last two Q&A's on page two were subsequently added by agreement with Dr. McCarville. If the does not satisfy your needs, please let me know. HMK:ku Attachment H. M. Keating Vfc_- (i * Hi. Confidential - Subject to Protective Order I C01 1fi 3 mo* , i t tr>AMC -- LOCATION -- FMONCI W. J\ MeCarville - A3NB - .>-3257 DATC 'SW*j c c t : -i RlflREN Ct t Apiil 24, 1979 Q&A. - AGENT ORANGE # |gl W . G.. KRUMMR1CH PLANT W ' 'Mr. D. R. Bishop Mr. H. M. Keating. - G4WA/ N r . George Roush - A2SA M r . M. C;. Throdahl' - DID TO :^ Mr. W. B. Papageorge - G4WA -- 1-- - Attached is a preparedness Q&A on Agent Orange for internal use at'W. G. Kruimnrich Plant. Questions from outside should be referred to Dan Bishop or * myself. ,/hmv Attachment Confidential-Subject to Protective Order i Q&A re "Agent Orange" at WGK (Internal use only) Q;: When did Monsanto make '"Agentf Oglnge" at WGK? 'i A: "Agent Orange", which was a mixture of the n-butyl este*\ of 2,4-D and the n-butyl ester of 2,4,5-T, was supplied to the. Government during the period 1965 through 1968. . most Q: What is the material in "Agent Orange" that is/itoxic to humans? A: An impurity in the 2,4,5-T known' as 2,3,7-,8-tetrachlorodibenzo' p-dioxin (2,3,7,8-TCDD). Q: How much 2,3,7,8 TCDD was in Monsanto's 2,4,5-T? As We don't know for sure. 'There a r e more- than 2D different 'tetrachloro dioxins possible., all of which .analyze about the same, using the techniques we had available 10 years ago, but* only the 2,3,7,8 isomer has* been shown to be highly toxic.in animal studies.' Q; What are,,the long-term effects of exposure to 2,3,7,8-TCDD? i Ar There are- no long-term, health, effects known, in humans,, but because of some recent studies in monkeys and earlier studies in mice and rats, the government has started a study to examine human exposures. Q: What is Monsanto doing t-o study workers exposed to 2.,4,5-T? A: Although we have had experience with 2,4,5-T and presumably with 2,3,7,8-TCDD at Nitro dating back- to. 1949, we have seen no long-term effects on health other than chloracne. Last summer agreed to take part in an independent study of Nitro employees carried out on behalf of the World Health Organization. Nitro was chosen because exposure levels he3-i-avd to be many times: what would be expected in the. normal production and handling of 2,4,5-T were experienced, in 1949 during- a process accident. Since even in the routine operations the exposure levels at the Nitro location were believed to be considerably hig1 # than WGK, we believe it is necessary to complete this study as soon as possible. When we finish this study later in 1979, we will know whether there is any need to* expand the study to WGK. Confidential-Subject to Protective Order r-2* Q&A - 'Agent Orange - WGK Q: Why rfid Monsanto agree to the Nitre study last summer? Hi- A: Since the Nitro experience i&Pthe- oldest re corded-incident involving 2,3,7,8 TCDD and since it involved the largest exposed population (228) until the Seveso, Italy, episode in 1976, and also because we had not observed any long-term fects, the WHO believed that a detailed follow-up after -.-0 years might provide valuable information. At the time ~we agreed to the Nitro study, the1"Agent Orange" question had not even been raised. 2= From the ^studies with monkeys, mice a n d rats what would you say Is the possible effect on ay health of my four years of exposure to contaminated 2,4,5-T? `'As The only known human effect is chloracne. The purpose of the study at Nitro is. to? uncover any other long-term effects. Q; What has been the effect so far on the- exposed population at Seveso .. Italy? Ai The initial irritating .effect caused some cases -of chloracne. We axe hot aware of any other known effects. Confidential-Subject to Protective Order