Document 6BEZKeRR5Q8aLZBO1grQ4Jkao

2728 VINYL CHLORIDE VINYL CHLORIDE CAS RN: 75014 mf: CjHjCl; mw: 62.50 NIOSH #: KU 9625000 Colorless liquid or gas (when inhibited), faintly sweet odor, mp: -160; bp: -13.9, lei = 4%, uel = 22%; flash p: 17.6F (COC), fp: -159.7, d(liquid): 0.9195 @ 15/4, vap. press: 2600 mm @ 25, vap d: 2.15, autoign. temp.: 882F. Slightly sol in water; sol in ale; very sol in ether. SYNS: CHLOROETHENE CHLOROETHYLENE CHLORURE OE V1NYLE (FRENCH) CLORURO Dl VINILE (ITALIAN) ETHYLENE MONOCHLORIDE MONOCHLOROETHENE MONOCHLOROETHYLENE (DOT) vinylchlorid (german) vinyl chloride (dot) VINYL CHLORIDE MONOMER vinyl c monomer winylu chlorek (polish) TOXICITY DATA: 3 mma-sme 23000 ppm otr-rat-ibl 2000 ppm/14W-I hma-rat/sme 1 pph/24H-C ihl-man TCLo-'JO mg/m3 ($Y male) ihl-rat TCLo:500 ppm/7H (6-13D preg) ihl-rat TCLo;1500 ppm/24H (1-9D preg) ihl-rat TCL06OOO ppm/4H (12-18D preg): ETA ihl-man TCLo:300 ppm/4Y-r CAR orl-rat TDLo;10 gm/kg/52W-l:CAR ihl-rat TCLo:30 ppm/S2W-i:CAR ihl-rat TCL06OOO ppm/4H/(12-18D preg):CARC ipr-rat TDLo:21 mg/kg/65W-I:ETA scu-rat TDLo:21 mg/kg/67W-i:ETA ihl-mus TCLo `50 ppm/30W-I.CAR ihl-ham TCLo:30 ppm/4H/30W- I=CAR ihl-mus TC:2500 ppm/26W-I: NEO ihl-rat TC:250 ppm/32W-i:CAR ihl-mus TC:30 ppm/4TW-I: CAR orl-rat TD;34 gm/kg/3Y-I:CAR ihl-mus TC:2500 ppm/26W-I:NEO ihl-mus TC:2500 ppm/35W-i: CAR ihl-rat TC ' 250 ppm/2Y-l:CAR ihl-ham TC 500 ppm/48W-I:NEO ihl-rat TC:230 ppm/SOW-LCAR ihl-rat TC -50 ppm/37W-i:CAR orl-rat LD50:$00 mg/kg ihl-gpg LCLo-'20 pptn/30M CODEN: MUREAV 91,381,81 ARTODN 47,71,81 MUREAV 91,381,81 OTPZAB 24(5),28,80 TXAPA9 33,134,73 TXCYAC 11,43,78 ANYAA9 271,431,76 JOCMA7 16,809,74 APDCDT 3,216,76 ANYAA9 271,431.76 ANYAA9 271,431,76 APDCDT 3,216,76 APDCDT 3,216,76 ANYAA9 271,431,76 APDCDT 3,216,76 ENVRAL 16,283,78 JTEHD6 4,15,78 JTEHD6 4,15,78 EVHPAZ 21,1,77 ENVRAL 16,285,78 ENVRAL 7.387,74 AANLAW 36,1,74 MELAAD 65,421,74 MELAAD 65,421,74 MELAAD 65,421,74 DOWCC* 83DVA7 -.1160.38 Aquatic Toxicity Rating: TLm96: over 1000 ppm WQCHM* 3,-,74. Carcinogenic Determination: Human Positive IARC** 19,377,79. TLV: Air: 5 ppm DTLVS* 4,427,80. Toxicology Review: FAZMAE 18,365,74; JTEHD6 1(1),47,75; CMTVAS 10(3),49,73; CHWEAP 70,5,74; CANCAR 39,1792,77; MUREAV 32(2),93,76; ZHPMAT 166,113,78; BNYMAM 54,413,78; ABMHAM 35,585,77; CBINA8 22,117,78. OSHA Standard: Air: TWA 1 ppm; CL 5 ppm/15M FEREAC 40,27073,75. DOT: Flammable Gas, Label: Flammable Gas FEREAC 41,57018,76. Occupational Exposure to Vinyl Halides reem std: Air: TWA 1 ppm; CL 5 ppm/15M NTIS**. "NIOSH Manual of Analytical Methods" VOL 1 178. NIOSH Cur rent Intelligence Bulletin 28, 1978. Reported in EPA TSCA Inventory, 1980. EPA TSCA 8E No. 03780104--Followup Reply Received as of April, 1979. THR: HIGH irr via inhai route and to skn, eyes and mu mem. In high cone, it acts as an.anesthetic. Causes skn bums by rapid evaporation and consequent freez ing. Chronic exposure has shown liver injury in rats and rbts. Circulatory and bone changes in the fingertips reported in workers handling unpolymerized materials. A hmn brain CARC and an exper brain CARC, NEO, ETA via inhai route. May cause local irr. Fire Hazard: Dangerous, when exposed to heat, flame or oxidizers. Large fires of this material are practically inextinguishable. Spontaneous Heating: No. Explosion Hazard: Severe, in the form of vapor, when exposed to heat or flame. Also, on standing, forms per oxides in air and can then explode. Disaster Hazard: Very dangerous; when heated to decomp it emits highly tox fumes of phosgene; can react vigor ously with oxidizing materials. Before storing or han dling this material, instructions for its use should be obtained from the supplier. To Fight Fire: Stop flow of gas. For further information see Vol. 1, No. 3 of DP1M Report VINYL CROTONATE CAS RN: 14861064 mf: CsHgOj; mw: 112.14 NIOSH #: GQ 5850000 Slightly sol in water, d: 0.9, vap. d: 4.0, bp: 134, flash p: 78F (OC). SYNS: CROTON1C acid, VINYL ESTER TOXICITY DATA: skn-rbt 500 mg open MLD eye-ibt 300 mg oH-rai LD50 6500 mg/lcg 1 2-butenoic acid, ethenyl es ter CODEN: UCDS** 11/15/71 AMIHBC 10,61.54 UCDS** 11/15/71 THR: Skn, eye irr in rbt. See also ester. LOW via oral route. Probably very irr. Fire Hazard: Dangerous, when exposed to heat, flame or oxidizers. To Fight Fire: Alcohol foam. VINYLCYCLOHEXANE MONOXIDE CAS RN: 106865 mf: CeHuO; mw: 124.20 NIOSH #: RN 8770000 Liquid, very slightly sol in water, d: 0.9598 @ 20/20, bp: 169, flash p: 136F, fp: -100. SYNS: 1.2-EFOXY-4-VINYLCYCLOHEX ANE 4-vinylcyclohexane, 1,2EFOXIDE 4-VINYLCYCLOHEXENE-1,2EFOXIDE VINYLCYCLOHEXENE MONOXIDE 4-VINYLCYCLOHEXENE MONOX IDE 1-VINYL-3.4-EFOXYCYCLOHEXANE 3-VINYL-7-OXAaCYCLO(4.1.0) HEPTANE UCC 108067 9796 Vinyl Chloride bituric acid; 5-vinyl-5-( 1 -methylbutyDbarbituric acid; butyvinal; Sped*; Optanox- CjIH,(NiO mol wt 224.23. C 58.91%, H 7.19%. N 12.49%. O 21.40%. Prepn: Seefelder, Festschr. Carl Wurster I960, 71. CA. 56, 9928d (1962). 0 akin, mucous membranes; narcotic in high concentrations; has caused liver, kidney injury in exptl animals; -Irish in Industrial Hygiene and Toxicology vol. 2, F. A. Patty, Ed. (Interscience, New York, 2nd ed.. 1962) pp 1303-1307; Prendergast et aL, Toxicol Appl Pharmacol 10, 270 (1967). 9799, 17a-Vlnyl-19-norteatoiterone, 17-Hydroxy-19nor-17a-pregna-4,20-dien-3-one; l7-hydroxy-17a-vinyl-4estren-3-one; 17-hydroxy-13-methyl-17a-vinyl-1,2,3,6,7,8,9,10,11,12,13,14.16,17-tetradecabydro-15/f-cyclopenta[c]phenanthren-3-one: Nor-Progestelea; norvinisterone. C^HjjOp mol wt 300.42. C 79.95%, H 9.39%, O 10.65%. Prepn; Colton, UJ5. pats. 2.6S5.318; 2,802,015 (to Searle). Crystals, mp 90-91.5*. Caution: Abuse may lead to habituation or addiction. theraf CAT; Sedative, hypnotic. 9796. Vinyl Chloride. Chloroethylene. C,H,C1; mol wt 62.50. C 38.43%, H 4.84%. d 56.73%. CH,--CHC1. Prepd from ethylene dichloride and alcoholic potassium: Regnault, Ann 14, 22 (1835); by balogenation of ethylene; Miller, Jenks, U.S. pat. 2,896,000 (1959 to National Distillers and Chemical Corp.). Review of mfg processes; Faith. Keyes A Clark's Industrial Chemicals, F. A. Lowenbeim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed.. 1975) pp 868-873. Comprehensive monograph on toxicity of vinyl chloride; Ann N.Y. Acad. Sci 246, 1-337 (1975). Review of carcinogenicity studies: IARC Monographs 19, 377-437 (1979). Colorless gas; liquefies in a freezing mixture. Polymerizes in light or in presence of catalyst, mp --153.8*; bp -- 13.3T. dj* 0.9106; ng 1.3700. Vapor press, at 20*; 2530 mm Hg. Flammable/ Flash pt -- 78*C (dosed cup). Sol in ale. ether, carbon tetrachloride, benzene. Slightly sol in water. CautionCauses "vinyl chloride disease". May be nar cotic in high conens. Consult latest Government regulations on allowable concentrations in air. If spilled on skin rapid evaporation can cause local frostbite. This substance has been listed as a carcinogen by the EPA: Second Annual Report on Carcinogens (NTP 81-43, Dec. 1981) pp 238-240- USE: In the plastics industry; as refrigerant; in organic syntheses. 9797. Vinyl Ether. 1,1'-Oxybisethene; divinyl ether; di vinyl oxide; ethenyloxyethene. C,HtO; mol wt 70.09. C 68.54%, H 8.63%, O 22.83%. CH,--CHOCH--CH,. Prepn: Major, Ruigh, UA pat. 2,021,872 (1935 to Merck A Co.); Mittag, Smidt. UA pat. 2,832,807 (1958 to Consortium fur electrocbem. Ind. GmbH). Very volatile, flammable liq; characteristic odor. Dec on exposure to light or to add fumes, forming acetaldehyde, and polymerizes to a solid glass-like mass. d& 0.774; dj* 0.773. bp 28.4*. ng 1.3989. Crit temp 183* (calc). Critical press, about 30 atm. Specific heat about 0.53 cal/g. Flash point (dosed cup) < -- 3CT (< -- 22*F). Explosives limits (% by vol in air), lower: 1.7, upper; 27.0. Autoignition temp 36O' (680*F). 0.53 g dissolves in 100 g water at 3T. Oil-water soty coefficient at 37*; 41. Miadble with alcohol, ether, oils and other organic solvents. Keep protected from light and acid fumes. In a cool place, and away from an open flame. Lethal concn for mice in air: 51,233 ppm. theraf CAT: Anesthetic (inhalation). 9798. Vinylidene Chloride. 1,1-Dichloroethene; l,I-dlchloroethylene; arym-dichloroethylene. CAt-Cl* mol wt 96.95. C 24.78%, H 2.08%. a 73.14%. CHj-Ca,. Prepn from ethylene chloride: Rally. UA pat. 2,140,548 (1938 to Dow). By dehydrochlorination of 1,1.2-trichloroethane: Conrad, Gould. U.S, pat. 2,989,570 (1961 to Ethyl Corp.). Liquid. Mild, sweet odor resembling that of chloroform, df 1.2129. mp -122.5*. bp*, 31.7*. ng 1.4249. Flash pt -- 15*. Practically insol in water. Sol in organic solvents. At temps above 0* and especially in the presence of oxygen or other suitable catalysts polymerizes to a plastic. Several inhibitors to preserve the monomer have been invented. Uncontrolled polymerization may lead to explosive reaction products with oxygen or ozone: Reinhardt, Chem Eng. News 25, 2136 (1947). USE: Intermediate in the production of "vinylidene poly mer plastics" such as Saran and Velon. Caution- Irritant to Crystals from ethyl acetate + petr ether, mp 169-171*. -t-36". 9800. Violacein. 3-[1,2-Dihydro-5- <5- hydroxy- IH-indol-3-yl>-2-oxo-3H-pyrrot-3-yiideneJ-1,3-dihydro-2H-indot-2-one; 3-[2- (S-hydroxyindol-3-yl)-S-oxo-2-pyrrolin-4ylidenef-2-indolinone; 3-[2-(5-hydroxyindol-3-yl)-5-oxopyrrolin-4-ylidene]oxindole; 5-(5-hydroxy-3-indolyl)-3(3-oxindolylidene)-2-oxopyrroline. C^HuN.Oy mol wt 343.33. C 69.96%, H 3.82%. N 12.24%. O 13.98%. Pigment isolated from Chromobacterium violaceum (Bacillus violaceus); Tobie. J. Bad. 29, 223 (1935); Strong. Science 100, 287 (1944); Ballantine et al, J. Chem. Soc 1958, 755. Struc ture and synthesis: Ballantine et aL, ibid. I960, 2292. Re. view: DeMosa in Antibiotics vol, 2, D. Gottlieb, P. D. Shaw, Eds. (Springer, New York, 1967). Purplish-black needles, prisms. Practically insol in water; slightly sol in alcohol; moderately sol in dioxane. 9801. Vlolaxanthin. 5,6:5' ,6'-Diepoxy-5,5` ,6,6'-tetrahydro-0,B-caroune-3,3'-dioUvaxxMbsa diepoxide. C*H,,O* mol wt 600.85. C 79.95%. H 9.39%, O 10.65%. Wddy distributed carotenoid pigment. Formed in plants from zeaxanthin. Isoln from yellow pansies (Viola tricolor): Kuhn, Winterstein. Ber. 64, 326 (1931). Structure: Karrer et al, Hetv. Chim Acta 14> 1044 (1931); 16, 977 (1933); 19, 1024 (1936); 27, 1684 (1944). Partial synthesia: Karrer, Jucker. ibid. 28, 300 (1945). Abe cooftg: Bartlett et al. J. Chem Soc (C) 1969, 2527. Isoln from Viola tricolorand configura tion of the 15-rfi-isomcr: P. Molnar, J. Szaboles. Phyto chemistry 19, 623 (1980). Orange prisms from methanol, reddish-brown acicular crystals from CS-. mp 200*. [a]ft +35* (c -- 0.08 in chloro form). Absorption max (in a): 471.3, 442.5, 417.5 nm. Sol in alcohol, methanol, carbon disulfide, ether; almost insol in petr ether. 15-cls-Isomer, irregular yellow plates from benzene/- petrol, mp 109*. uv (logs 4.91, 4.98, 4.8 orange prisms. 9802. Viologen. the chlorides of cert dipyridyl. Presentl diiodides. Prepn: Michselia, Hill, J. r Physiol 16, 859-87; lion-reduction indi> very negative. In color is exhibited b oxidized form is tl potential of these si of electrochemistry Rev. 10. 49-82 (19* Ethyl viologen, I, yl-y.y'-dipyridyliu. volts. Benzyl viologen, ium, N,N'-dibenzy* 30r: --0.359 volts. Betaine viologen, mal potential at 3C Dimethyl analog USE: As biologic 9803. Violuric '5-oxime; alloxan (hydroxyimino)bar C 30.58%, H 1.93? as s mixture of k< and bydroxylamin chard, Ber. 32, 17', Orthorhombic c sol in water to a FeClj produces bl use: Analytical cations. Forms * Chem Soc 80, 56 9804. Vlolutin. copyranosjDoxyfbe 2-0-vidanoside; vt 51.12%, H 5.87%, Isoln and jtructur, Bull Soc. Chim B 341 (1929). Synt 1932, 2770. Add binose and D-gluc Hygroscopic n. 173*. after prelirm sol in water, sol tone, ethyl acctat 9005. Vlomyc dn B; Vinactane; 685.71. C 43.79* otic substance pr eluding A punice al. Am Rev. Tu, duction: Marsh Freaney, U.S. p structure: Yosht Alternate struct: Page 1430 Consult the cross indsx before using this section. UCC 108068