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E . I. d u P o n t d e N e m o u r s & C o m p a n y
INC9RrRATIO
W il m in g t o n , D e l a w a r e 19898
POLYMER PRODUCTS DEPARTMENT
EXPER IM EN TAL. STATIO N
PERSONAL AND CO N FID EN TIAL
cc: A. J. Dahl B. W. Karrh
L. J. Papa Pral File I.C.
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- 353 - N11400 - 269
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May 20, 1981
T0: DR. Y. L. POWER - PPD, Washington Works
FROM: S. S. STAFFORD
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ANALYSIS OF BLOOD SAMPLES FOR PERFLU00R00CAN0ATE (Job No. 810-578; PRAL Nos. 81-1827-1844; Notebook Nos. E22514,E26238)
As requested in your letter of 5/1/81 to L. J. Papa, the 18 blood samples submitted then have been analyzed for perfluorooctanoate (Cg). Results and sample identification are given in the attached table.
As noted there, the analysis was done using a gas chromatographic method specific for Cg (Lab Method Number ES-567) but results have been reported as ppm F for comparison with total organic fluorine analyses. Precision is + 10% relative standard deviation over most of the concentration range, somewhat less at the lowest values. The lower limit for quantitation is 0.007 ppm F (0.01 ppm perfluorooctanoic acid), with a detection limit of 'v 0.004 ppm which can be distinguished from the reagent background but not well quantitated.
Please contact me (772-4440) or L. J. Papa (772-2745) if you have any questions regarding the analyses. General questions on blood sampling can be directed to J. W. Raines or L. F. Percival.
Attachment jah
Key Words: Perfluorooctanoic Acid Perfluorooctanoate Blood Analysis GC
T h e re 's a w o rld of th in g s w e re d o in g s o m e th in g ab ou!
000079
EXP000020 EID713834
TABLE 1 CONCENTRATION OF PERFLUOROOCTANOATE IK BLOOD (a)
Sample PRAL No.
81-1827
81-1828
_______________ Date Sampled P.R.No.
4/21/81
4538
4/22/81
30-2350
Name
81-1829 81-1630
4/23/81 4/24/81
3390 4746
81-1831 81-1832
4/24/81 4/27/81
4747 4675
81-1833 81-1834 81-1835 81-1836 81-1837 81-1838 81-1839 81-1840 81-1841 81-1842 81-1843 81-1844
4/27/81 4/27/81 4/27/81 4/27/81 4/27/81 4/27/81 4/27/81 4/27/81 4/27/81 4/27/81 4/27/81 4/1/81
4673 4664 4706 1498 W.S. 4053 4668 4584 4674 4667 4678 1920
GC Analysis______________
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Date Analyzed [Cft] , vjr F/g bloo
5/4/81 5/4/81
1.2 0.26
5/6/81 5/4/81
0.52 <.007
5/4/81 5/8/81
0.079 0.42
5/7/81 5/7/81 5/7/81 5/4/81 5/4/81 5/7/81 5/8/81 5/8/81 5/8/81 5/8/81 5/6/81 5/6/81
0.48 0.050 0.43 2.7 0.39 0.27 0. 020 0.0091 0.35 0.012 0.031 1.3
(a) Analysis as described in Lab Acid in Blood, Gas Chromatographic Method", S. Stafford, 4/3/81), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration standard.
(b) Although the analysis is specifically for perfluorooctanoate (acid or salts), concentrations are given in ppm fluorine for comparison with the results of total organic fluorine analyses. (ppm F = 0.688 x ppm perfluorooctanoic acid) Estimated uncetainty is + 10% relative standard deviation. The lower limit for quantitaion is 0.007 ygF/g. The detection limit is n. 0.004 pgF/g, but concentrations in that range cannot be well quantitated and are reported as < 0.007. None detected (n.d.) is reported for samples with [Cg] < 0.004 ppm, which cannot be distinguished from reagent background.
REDACTED*
EXP000021
EID713835
000080
