Document 6B34MLyGDE4DBaQV8awxYoMyE

AR&6- 2lf-6sr H 000654 AP.&H6 - C-8 IN BLOOD - HISTORICAL 1978 1979 1980 1981 1982 1990 1993 1995 Informed by 3N that C-8 is found in the blood of exposed workers and persists for a long time. C-8 found in blood of DuPont workers. Workers with blood C-8 found to have normal liver function. Birth defects scare - additional sailing. Blood program continues on voluntary basis - no trends noted. Formal review of blood data. Journal Of Occupational Medicine study of 3M workers. First 5-year "snapshot". 000655 01/05 '96 22:52 ID:LfiNItKPHX380 FRX: PAGE 4 BLOOD MONITORING THIS IS THE ONLY MEASURE WE HAVE OF TOTAL EMPLOYEE EXPOSURE PROBLEMS BIOPERSISTENCE HAKES DATA INTERPRETATION DIFFICULT SAMPLING IS INVASIVE LENGTHY ANALYSIS IS RUN BY ONLY ONE LAB NO AEL 000656 WASHINGTON WORKS VOLUNTARY BLOOD TESTING 0 - <1 ppm 1 <3 ppm >3 ppm TOTAL 1993 9 2 2 13 1994 47 5 1 53 No systematic comparison with air sampling is possible. C-8 specific GC analysis run by National Medical Services, t Correlates well with new 3M analysis. 000657 1995 C-8 IN BLOOD SNAPSHOT" PURPOSES Monitor the overall effectiveness of our C-8 industrial hygiene programs. Create and maintain a continuous data base for epidemiologic surveillance of our exposed population. Provide closure for issues raised by the 1990 data review. Honor employee requests for voluntary testing. TEST POPULATIONS Employees in C-8 jobs (82 of 140) Employees not in C-8 jobs with a previous result >3 ppm (9 of 12) Pensioners with a high previous result (9 of 19) Volunteers (28) 06S8 RESULTS SUMMARY - OPERATORS JOB 08PE 08PF 08PH 08PI OfiPJ Q8PH 18PA 18PB 18PC 18PD 18PJ 18PK DESCRIPTION autoclave polykettle dispersion FP finishing FP packout -8 dryer recovery FEP polykettle FEP extruder/oven FEP wet finishing FEP packout PFA/FEP bead FEP safety/disp 1995 AVERAGE (n) 2.3 (7) 2.6 (6) 0.5 (2) 2.0 (6) 0.7 (7) 1.7 (2) 2.3 (4) 1.5 (6) 3.0 (1) 0.1 (4) 0.7 (2) 2.1 (2) 1989 AVERAGE ini 3.0 (4), 7.0 (3) 2.5 (3), 8.5 (1) 1.0 (2), 7.5 (1) 2.0 (6) 0.5 (3) RESULTS SUMMARY - MECHANICS 58MC 58HD 58MG 68MA 68HB FP/disp/gran/TA general shift process ESI general shift FEP E&I 1.4 (1) 1.1 (8) 0.8 (7) 1.1 (5) 0.9 (7) -- 000659 HALF LIFE RESULTS FROM PENSIONERS DATE8PPM 4/89 5.7 3/87 1.2 9/81 6.5 3/88 2.8 8/84 2.4 7/84 5.9 3/85 3.0 9/82 6.3 3/88 1.7 RET. DATE 4/91 6/92 4/85 12/92 4/85 12/81 4/85 12/82 12/93 C8 DATE PPM 3/95 4.3 3/95 1.1 3/95 1.1 3/95 2.2 3/95 .72 3/95 .94 3/95 .14 3/95 .57 3/95 2.4 For * results, n=4 average *= 3.9 sigma -- 1.4 using loa n . --.301 t no ti/2 1/2 LIFE fYEARS) 9.7 22 3.9 6.5 5.7* 4.0* 2,3* 3,5* --- 000660 OTHER OBSERVATIONS 1. VOLUNTEERS a} One of 17 is above 1 PPM b) Average of other 16 is 0,4 PPM 2. ACTIVE EMPLOYEES WITH PREVIOUS HIGH RESULTS in C-8 job not in C-8 job Down 2 6 Same 3 2 Up 4 1 3. THREE EMPLOYEES OVER 3 PPM FOR THE FIRST TIME 000661 'll TEST POPULATIONS 1. Employees in c-8 jobs (82 of 140) 2. Employees not in C-8 jobs with a previous result >3 ppm (9 of 12) 3. Pensioners with a high previous result (9 of 19) 4. Volunteers (18) 000662 OTHER OBSERVATIONS 1. HALFLIFE ESTIMATES FROM PENSIONERS Average 3.8 years Signa 1.2 years n-4 2. VOLUNTEERS a) One of 17 is above 1 PPM b) Average of other 16 is 0.4 PPM 3. ACTIVE EMPLOYEES WITH PREVIOUS HIGH RESULTS a in C-8 job not in C-8 job Down Sane Up__ '.2.T ~ "T ~ 621 4. THREE EMPLOYEES OVER 3 PPM FOR THE FIRST TINE 00663 PATH FORWARD Finish Data Analysis Employee Communication Site Industrial Hygiene Efforts Toxicology Work (Do we need a BEI?) Continue Annual Voluntary Testing Take Another Snapshot In 2000 000664