Document 6B0Zve2K2Lnom6jpOb90xLVo6

NOV 5 19B4' 33^-3) on u { a s k /rijfAp \i`- ^ ~ RECEIVED ENVIRONMENTAJ. PROTECTION AGENCY f <n\f n r, pa a Note to Docket No. EN-84-05: CENTRAL DOCKET SECTION Attached are translations of studies I recently received from the Office of International Activities related to blood lead and blood pressure. Rob Weissman TEH 0350345 N36719 DU P050298982 TR 84-0257 BLOOD LEAD AND BLOOD PRESSURE T. Moreau, G. Orssaud, B. Juguet, and G. Busquet Rev. Epidemiol. Sante Publique, vol. 30, pages 395397, 1982. Translated for EPA by: SC 1 X RAN 1482 East Valley Road Santa Barbara, California (805) 969-2413 93108 N36719.01 DU P050298983 Letter to the Editor Blood lead and blood pressure. Preliminary results of a cross-sectional study of 431 male subjacts.* Gent 1emen: An article dealing with the factors of variation of i blood lead in the general population (Awad et al. 13) was published in a recent issue of the review; among other things, it did not establish a relationship'between blood lead and blood pressure. We present here the preliminary results of a study in which this relationship is shown. The study population is made up of 431 male subjects, aged 24 to 55 years (average 41.4), untreated for hypertension, belonging to the Paris police department. For each subject, examined during a routine medical visit, blood pressure was measured with a mercury apparatus; a blood sample was collected; the level of lead was measured on total blood by atomic absorption spectrometry <Jarell-Ash 858 apparatus); and the daily consumptions of wine and tobacco were obtained by questionnaire. Data were collected from May 1980 to February 1981. Statistical tests were carried out using the logarithms of the blood lead values, which appeared to be normally distributed. Work carried out under 1NSERM CRL contract no. 79-5-438-8. By: T. Moreau. 1 TEH 0350347 DUP050298984 The average blood lead values as a function of systolic blood pressure are shown in Table li they differ very significantly (p < 18-*) with an increase of about 25V. between the lowest blood pressure class (less than 120 mm Hg> and the highest blood pressure class (over 166 nm Hg),.the correlation coefficient value is B.23 (p < 18-5>. Also, the blood lead, as in Awad et al . 13, appears very significantly correlated with age Cr -- 8.20, p < 18-*), consumption of wine and tobacco (r = 0.31, p < 10-*} r = 0.21, p < 10-*, respectively). However, the blood lead-systolic pressure relationship persists after taking into account simultaneously the .three variables (partial correlation coefficient 0.14, p < 10--). It was also corroborated by the existence of a significant correlation between blood lead and cardiac rate, itself very much linked to systolic pressure; the correlation disappears after taking the linkage into account. Taking into account corpulence (defined as the ratio Weight/Height), not correlated with blood lead (r = 0.05), does not alter these results. Finally it has be^n verified that the blood lead-systolic pressure relationship exists for each of the more homogeneous groups of subjects examined during a given month. As far as diastolic pressure is concerned, it is also linked in a significant manner to blood lead levels, but more loosely <r 8.10, p < 0.85)} the weakness of this correlation is probably explained by the poorer quality of the diastolic TEH 0350348 DUP050298985 pressure measurement, as suggested by its weak relationship to age and corpulence <r = 8.18, r ** 0.21, respectively), compared to that observed -for systolic pressure <r ** 8.28, r ** 0.34, respectively). The existence of a positive connection between blood lead and blood pressure is controversial in the recent literature! it was shown by Beevers et al 2, 33 and Khera et al. 43 who, with a group identical to ours with respect to sex and profession, compared average blood lead level of subjects with elevated blood pressure with that of other subjects. The statistical analysis chosen here, as well as in Awad et a). , is different, since it consists of calculating the correlation between bipod level and blood pressure in the general population. Looking at these results together, it appears necessary to conduct other stqdies that will permit, in particular, approaching the physiological mechanisms of the blood lead--blood pressure relationship. T. Moreau <1>, G. Grssaud 2), B. Juguet <3>, G. Busquet <4>. <1> INSERM, U. 169 <J. Lellouch), 16, av. Paul-VaiII antCouterier, 97887 Vi 1lejuif Cedex. <2> Laboratory for Research in Cardiovascular Diseases of the DASS, 27, rue Lacordaire F 75015 Paris (Pr. J.--R. Claude). <3) Health Laboratory of the City of Paris, 1<2), rue des Hospital iers-Saint-Gervais, F 75815 Paris <Pr. B. Festy). <4) Department of Nuclear Medicine, CHRG, F 38788 La Tronche , 3 TEH 0350349 DUP0502 98986 TABLE 1. Means of blood lead values (yg/) according to blood-pressure (mm Hg) ^00 vyMOfayvx 119 120 - 129 150- 159 140 - 149 150 159 ICO + u ^ SijnificxJion ^ HomWmk =tr C4. IU x 35 169 * 47 m* 191 * 57 203 * 57 204 * Cl < I0-* 3 -- EBaoift 25 161 115 79 26 29 iSystolic pressure. %B\ood lead standard error. Number of subjects. 4Signi-ficance. 0350^50 4 DUP0502 98987 BIBLIOGRAPHY 1. Amad L., Huel G., Lazar P., Boudene C.: Factors of inter individual variation in blood lead. Rev. Epidemiol. e.t Sante Publ., 1981, 2Z, 113-124. BIBLIOGRAPHIE 1, Awad L, Hud G,, Laur F,, Soudfe* C.: Feoeun d* variation i--rmitirirtmlW di In pkcaUm- fav. EfUtmM. t Smut Ml. mi, 39. 115-124. t, lenn D.G, EnkiM E, Mmm M. Buak A.D, CjmWd LC. CoMkq A, Mcn U.K. Hiwtkni V.M.: Hood-Wad and kipotraimi. Lmtcwt. 1976 July. 3. J.J.. 3. D.G, Cn.ictafcmk |.L. Ymim W.B.. Carter C. F,, Ccddber* A.. Moore M IL: ilood-kad and cadmium in hrtir fcjrperwnrrorv. f. fmhot. Toxicol^ 1WO. 3. 351-260. 4. Kbcra A.K.. Witter!** D.C.. Edwards K.W.. Waldron H.A.: Cadmium tad lead tevtla Is Hood awl uriac hi aerial of carbovaacufaw wed eormcmeiiw yrimo itu. /. Enmnei. Sndim I960, 14, 309.312. 5. FeUarmaa E.|.: HoodWad am* byyrmwiicm. Imc t i. 1970 Noecmlmr. 20. 1134. 03S0351 5 DU P050298988