Document 65wvxrzx9Jxq0aK5zxVo6n8EE

April 27, 1966 Mr. George- Pitts CBohxar8le8s/Pfize/r*/Company Terre Haute./ Ind. Mr. Dradford has asked me to send you toxicity information for our compressor lubricant!Pydraul AC.I A summary of the toxicity information may be stated as follows! In animal toxioity studies with Pydraul AC. the oral lethal dose in rats is approximately 40 grams per kilogram and for rabbits, 3.5 to 4.3 grams per kilogram. The greater sensitivity of rabbits is typical of this type of fluid. This lethal dose is of suoh an order, however, that the fluid may be considered only 'slightly toxic" to man from the standpoint of accidental ingestion of single oral doses. The fluid may be absorbed through the unbroken skin of rabbits in doses resulting in death, but again the minimum lethal dose is such that accidental massive skin exposures to man do not present a hazard. Skin and eye irrita tion studies with rabbits classify the fluid as a mild irritant. Laboratory animals survived six-hour exposures to an atmosphere saturated with the vapors of the fluid. On the basis of .this data, it is con cluded that Pydraul AC requires no special handling precautions other than avoiding prolonged or repeated skin contact. Accidental splashing in the eyes will result in modsratsly severe pain and irritation but no permanent damage should result. I am not sure what your particular application may be that raises the question of toxicity. We have run some rather limited tests on a particular compressor where the air downstream showed no detectable levels of the lubri cant. It must be pointed out, however, that there are many faotors which could affeot the amount, if any, of DSW 018745 STLCOPCB4005289 Mr. George Fitts April 27, 1966 Page 2 of any lubribant in the compressed air. Some of these Include the mechanical condition of the compressor, temperature of compressor cylinder w^Lls, variations,in operation, etc. / ' vH- It appears appropriate to us that,regardless of'the type -^v of lubrioant, if the air is to be used for breathing purposes, a filter should be placed in the line to remove not only any possible lubricant, but moisture, rust and any other possible contaminants. ( ' If the oompressed air is to be used in a food application, we would not expect that there would be any serious problem of adding toxic materials to the food. On the other hand, to prevent contamination or "adulteration," . "''again we believe that a filter in the line is desirable./ If I can be of any further service, please do not hesitate to let me know. Very truly yours. Elmer P. Wheeler Manager, Environmental Health Medical Department EPWjraJb oci C. Larry Bradford - Monsanto Qeneral Offices DSW 018746 STLCOPCB4005290