Document 65wd0N4B43dmjMNM24QY1GZ8R

CHEMICAL LIBRARY LITERATURE SEARCH 566 Building 73^' .f * i\ / v u/j !k^ /0O REGISTRATION i'nii ` EBCEIVET) RGp& fc-gtrf1I3T-J87 Bldg* Phone Charge MAY 311973 -------REGISTRATION------- ZOZVZV S * U By: Date: 'll-] Sources Checked: . ' : CHEMICAL ABSTRACTS C VW- Hi1-) \*i' S' V* V ' 2. APPLIED SCIENCE AMD TECHNOLOGY INDEX 3. U. 5' ENGINEERING INDEX BUSINESS PERIODICALS INDEX U. S. RESEARCH AND DEVELOPMENT INDEX ;*N*\ `V$ BIOLOGICAL ABSTRACTS ( l<\ WL- 1*^ \ q-J $) Z Mod- 7Tau,~T^. 1<H L i^Ul ^ <d : T* INDEX MEDICUS ^ . .' - *.'. - , 8.. SCIENCE CITATION INDEX ' y - ; 9- 10. JL1. 12. NUCLEAR SCIENCE ABSTRACTS BEILSTEIN'5 HANDBUCH der ORGANISCHEN CHEMIE ** 'CURRENT ABSTRACTS OP THE CHEMICAL LITERATURE AND INDEX CHEMICUS TOXICITY BIBLIOGRAPHY . ;- .i i. ` j ` v*..... ; 7V*" 'ivvi ' ^ yV :-i Terms searched in the above sources: c2JL*"WK- Civu+) ^ cfLe-^o~-- > A- ciiUwA^aA4' ' ;. ' ctfi-rve' JciJivv^ - Don't forget to contact Central Report Index (CRI) for information contained in Dow reports, etc. Call 6-3754. I suggest that you consult the following, for additional information: See on the reverse si'de of thi3 sheet. Was the material we sent you adequate? If so, we would appreciate knowing this. let us know and we will be glad to look further. I The Chemical Library Staff Phone: 6-0972 If not, "V V- " ^ tu g tei. s s a -a uJU^-^zfe Cor./..__ },y\OU>n _^ Q ^ic,: zzifz. l^i: so^u ^JL<rv&/^ ^ ^r' Jv2-a-CC pLt^^Tr-^^' a7 \TCL|l^A* e^. ............ ............................. ............... ..... _____ __ ^ ........................................................................................ ............ 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N /^~*" ^ C$SLv*^$L^ J &<*\*r* otA*** ..^9:. 3.?.^7 UAA-~Q cXy^^ dJLrrJu 'AU. ^>l - /vo^t&y... ..... -_X^l.`J 2.A3 st.,,. .. ,, n.'^ JJL^J5a / CLca^t- Cr* _____________ ^1 *v -a?3*w____ al ^sUm:^ ^yeinA..J2, jaJ / jUJLyXs......5933_\ JJtffk. R&s 131204 ( 56'< Sc)?%<] .. -* . s '-^:C~-,:)>,r.:t'js "V'^`'dRjt*3ra :""';W.-:'iij^^t?5 / ...-.* `'j---<.^'----.-^"<_-,-.^-rAt.W` 6~_`r i'-- .i1*^LX^'j .* - V ;" -: - i-;''. .. . y~-*X"<*L :%^'3 I* 's ,**, * 1 ._ -- .- '6 * ,* v-*-1 -V- *,-,,* --* ^*^-ra*,,. ^..?4~ .,.. ;V ' * 'V.-T 4 ' ( -T^u^-ES! V* ",,1 " ' , -ir*'. ^ 'V^ 30 : ;V. * fi CO ..- .^a --1 w ro o CO "'. 'r-. - ' MmMiI facMn oa tfc. ofasin. A. P. Storrenkif <w m paper filter, wubed. uid wri*bI. It a pOHihle to also and T. V. Riakuni (Med. lot.. Odoaa). Gtittma i ndt Ut hiu filur with f. ninati to del. (be iuol. StMk. M, No. 10, TO-aiHl).--Itnin dlini cuhchIuI reriduc. A relation between ma cooca. ol the duet ud IHilAaUoae ot th. method. Jdu How. Scon optical d. d the ga* ia nvea ia fraphkad Iona. <1 3.4-buopyiM la tho mulwn d - Q, flgljiBOtti t. V. Veada (Sri. Kneanri Koeitfn^Kuiol. sod p Tsridty ot rinyl chloride u determined by reputed On--logieri Iwto, Kiev), Gifwwe 5*at. 16, No. 10, J eipeeure at laboratory animate. T. R. Torketaoo, F. Oycn, 76-7(1981).--The --a--. of 3,44woaopyra0t vane* from I --d V. K. Rove (Dow Che*. Co., Midland. Mich.). Am, 0.029 to 04XB y/iOQ cn. m. m most places* but reached IB I /* Jify*. Au#.,J. 22, 351-^1(1961).--Aoiuui* allowed phrat.on eaobftlt phot end 0.5 mmr theJoKSikeHv iSchwc.Sp^otm -hr*- fUavr t6r muodotkiiiidtaofeiOy Oc,h2a0n0.fdudfoU10o0wptA.pf 4dao. ielyrf r7ia-byrl.cohplooriiduereina MinpipUc dotonniBfttfM d is Oc Itswt.{ lit. Tbn were noduA|w ti 50p.p-a. wbieh, wu rcooB* fkm%. hi, D. Bebm*. (New t Seed. 26, No. 11. 57-9M d*i u the max. for 64*. tine-w*fbtcd tzpowra for (1961).--Tbeair isponed throwfb 5%UiSOeDdif nhtellic 3 huitun*, Wm. MacL. Ptetve TI or TiO b pteeuit. filtered throueb a perchlaro^ayl filter. ^ Health atooeti el the commercial meltot d nta* The Alter heibed.fi>Md with KSaO.eod the meUdamolved cnttniutM /we stul wif R. 11. SUrkey. J. A. h 6% HiSO*. KiCiQi ia added to the HaSO* aola.ff the pH Quifley, nod J. W. McKelvey (Natl. Lead Co. of Ohio. tafWWfht to3-3-5 with KOH (Coegored), the vol.madettpto Cinonaati). Am, lad. //yf. Attoc. /. 22. 49^-7(1961 ).-- 10 ml. 5% HaSOw partially neutnUiaed to pH 3-3.5. a chop _ Since the Ka coouwiinaihei in Fe KAp ia remnved in the el felatitt aHn. added, and the O removed with a stream of J*f, the purified meui preaenta no haaard. The expoaure COt before potarefraphfc deta. of Ti. John Howe Scott during the cmelung ol Ka^cmumiaatcd icrap i> minimiied Deimiiiln)ii| monwhlernrijune In the enneepheru. by simpleindtutiixl bypoir cuotrulaand dils theecrap with II* N. Kua'mkhera (F. F. Erimtan Sci. Reamrcb last, nu&conlaminated wrap. The Ra eontent waa 1470 X Hyfiear, hfotcow). *{a*M i 5a*W. 26, No. 11, <VM 6 10**" *./*. of *bg and 0.00 X )0*" g./g. of stad. The av, (1961).--Two eolerimeum methoda are dmcribed. The dust level *m 16 X 10" ee./c. where the mat, acceptable more matin is an adaptation of the detn. of C*H ami i not concn. Wii3 X lO"11 x./- Wm. MacL. Pkite given in detail. It depend* on nitmtioo and mcawring the Deyeeidon ef IfaCl micmaereecla is the reeptmtovy tact. eohw formed tit alk. eohi. In the ether the air is passed_L. Dautrebande and W. Walkcnhorat (Silkoaia Rcnarcb through EtOH to dhnlw the monochloroatyrene and the last., Bochum, Oer.). Arch, &*9tro*m*nUU IlmUtk 3, onior ptuthieed by addn. of KOH and iwCflUNOi)i sms- 411-19(11161).--Dtpoutiuad NaCl aerosol ia the lunge aa a ml, John Howe Scott whole and in the last &I mL of tidal air ia tttwaely propar- A eihtaf d nhdlin ttmee el i nnmber ef organic cem- tmi to the breathing frequency. In the alveolar air the (Made. I'hilip W. Wet, Buddhadev Sot, Bharat R. Sant, d deporition exceed* 90% and i* mdependent of the breathing K. L. Mallik, and J. G. Sn Gupta (Loniciana State Ceiv*. frequency. bepuMUn rate* art comparable to these of e), J. CknmMlvg. 6, Sh)-g3(l961).--1The h.p. insof. aerosol* of the tame particle *iae. A min. deposition end the relative retention timet of * Lrgeno. of possibteerg. occur* for particles of 0.1 ft diameter a* dry oynth la the air pollutant* on "Ai1mi of tri m-tnlyi phosphate ud 14'* high humidity in the hup. the particle rise iaawn by a bydroiydipiupiouitrik am tabulated, htaxtin Jaeobsoo "" factor of 7, giving parttrim ***">af in rise to coal dust Increase In the Hnthn-- d pvttentfen el gaeen el port*!** of miu. rcteuthm rate. The deputed partkk* inefy dripereed duete by wiring wtth electrically charged are smallmt hi the dnepesr regMos of the lungs, water, V. P. &wv. Shmmf* Jiwh, Tndm Vusoyut. Raymond Zehnpfennig Ahach^/jrisdeeofri. Gowmk. lest. Ttmm A/t. 1960, c External measurement ef lung clearance. Experm--ts la No. 6. IS7-20S.--Bspt*. were carried out on dusU ft*-- rabbla with a mdioectivu geld eero--1. Lar* Friberg and Pband Za prodisethm. The investigation wa*conducted in Bo lluhu (Kwrfmds Inu.. Stsckhob). Arch* Feins (with the vof. of aw kept enact.) and in a -ward ttroUh J. 42o5(luGl).--Radraaetive Au" waa in* ftream ef aw (with a --uatrrilow and a crowcwveot of eke. traduced to the form d aerosol partwle* ol mean diameter charged water daeiy air). Km the expta.* wmndiir "' 34 up into the lung* f rabbits by uant of a tracheal tube, d^ fnun the mseRtaf shop of the Pb (aettty w-- need, with Distribution of in the body we* detd. by meant of a ptttkta* d av. diam. QJI*. In the expu. on a stream ot srintiUatma counter aud scanning dnj. Residual ectiv- dntty ak, at a rate innn cu. m./hr. the coagulated dM T m the lungs wat detd. m the notated ris--e at iatttval* pmtttkc wire collected in a wet cyclone. Varamtf im^true* / after rapouwe. Activity in the gasmuutectiaal tract n- tteuf*4*br***^*`fWTf d******* smf rsriinrp ntuti fm the rtiinr erra^e* with decreasing activity in the lungs- Activity in ami polarity of cinuat were terned. a* weU u the amu. of the Urar. fpkcu, edrauls. bluncl. and urine did not exceed water to be used. The timed contact of the charged water 0lr< of the lung activity. It is concluded that An aerosol wrihthed--tm the aw wa*changed erey 2.5*l< sec. Sfway* is on* rieaivd from the hutg* vip the bkmd, but ts einnnuted Ing by elec, charswl water under static wndiimt with i --m the trachea. Raymond dcbnpfennig voltage 90 kv. rmimd the efkriiveun* of purtlkatria 4 the Leber hygiene at the Karaganda cement factory. G. D. aw in onpsmus with praying with uncharged water by a Lyakh. />rmaWd. 5dy Tt**tral. A'oraekstaae (Alma-Ata: Intwri 10, 14, and 23 in spraying ihnA5, 10. and 15mia., Akad. Nauk Kartkh. S.S.K) ,%wsl 6, 1FJ3. dacwon u--. Wbee tbe vdup ua the charging dewe wa* 16-25 . U7-4f(IMI).-H)'pfwc iasnmioot revealed ndriw kv. and the dusty air passwd at a rate U3KHUI is./sec., the * dntim <95-96% dust porttrir* <6 a), with SKA content eCwtivwH* of spraying with rise, charged water wu 1.5- fl-51.Vr in the aw araund wktn' keitnol Bap- high 24 Cimeu lhai of gmyiig with uncharged water. Fresh duw values --c detected around chain conveyer* and vifara* R^rihf. Zlwr., ifri. 1961, Abstr. No. 6GEL wn. From mmbidity dgurve for 1951-1956. it wi> estab* J4m llaw -- kfebed that mpwauwy dnnic awng winter* who were ex- b el aalfurdiaxlde In the atmosphere by a posed to the cement dust w^* 1.5 tunca greater than among J, The omnnoakien of the ab- wtnk without warii naitact; pure and ulrtitau lUaavci Takaji Yew aod kolchno Shinra. 5r*. were 3 times highvt, and durum of the pcnpherml oerswu tUpU* (Omka Cuiv.) No. 6. 59-GV|9iiOt.-- An abwntwnt. system was 1.5 times higher. HecotnacadaUun* mriuikd; prif. by ddg. mi, HaOs wh. 1QCJQ l4d oauioed 0.00' " owm and etfnetive dustMnimping eqmpmcnt* musstenmg of IfsChand 04 lld(L awl *h--d the Itiihsl semifiv* raw material is the warm peraal* of the year, pun/yuig id ky towaid SOi dete. Takes Fukatonu waste*cvprUsd mtu the atm., and cw--niamtion of mhmktora, BribittD el the d--I to--trad-- In chimney g--. From Zkmr., Kktm. iwi. Afaatr. 313U. Mari* Kira* Bsttmos (hOtmiicv. Milan), f^sutn*^ JohnUam riu (Milw) IL ).-A anbri ddsuodlictiM Hygienir working r--dirt-- in the Karaganda eynfliotir --able f*m quite large uampka i* described. ie wlikh a rubber factory. R. G. Abubckeruv. f'rsswedd. 5dy measured vc4. <d gas (several hundred I.) i* drawl throogh * Ttentrii. A'suiithM (Alaiu*Ata: Akad. Kank Ksrakh. eofumu au<f. fimgucttt mil ia the form cl fairly Urge cry* S.S.R.) Ahmi 1956, No. 6, 24-7, diwuiwn 117-46.-- talc (5-10 mm. u dun.). The hrat given up by the gas { The suis sratrre ol isifrwnsaJ illness ui the pradtsetaou ot ttahsa (lie crystals mrk aipekully (Mhl3)f). The high synthetic rubber by KurhrrovNnirthud is Hg which puUutc* vis--iiy melted material mu mats psrtidu ms <1 n the sir, riutbing, cqmpaicot. sud wslh. N otidc* aid aret- in diam. Tbe Srignrue wit t* then dissolved ia O.v pwt of aldehyde vapor* ara aim injurious to hcatoh. INvmdk Vrf1*-! HtO, cite dust sspd. by AHnun through a Cud medical raamus. rcvculsd case* of rinnic Hg imuritw*. S' jIM" miiiiWiii x'- -ir`35?3tt :':.S&3g p.- , , -r-** ' :-Si ^0^ -*w ^ T , .-'V' r' ' r v.-In r^ ' p. -i -4 ^ . - . 1 ,v >..T.. .. .t.-; '-4 i IfT.-' '&r rv - . "UlmMU** fJ "'/.I*. * ' ` JC--: -``'T`a] WrijirA 3J S (0 03 N3 o O) ivv^jTV-'-i 'i;'^ '-S^ 1 '^:$m . v-v-'^r^ * 'J* '^ I .-j *>J* 'i* -*>- 7r*-i .' -. *4;i h*r& - -' :-tr- ri,^ 7: % * V;". .;:V~ - -'_* *. w* - - \r .,va V :-'; v:\*afi tog the tottkl period of development for Irovcs of barter and wheat varieties frith low arid rmtotaucs and for roou of all vari eties* The relatively low protoplasm permeability during the early developmental phases is eexompemed by dimuptiou of nor mal asimslatlau of nutritive substance* and is one of the cans-- that of cotoofKika to the ooml vatal ponttioa* Thto U tnt of poor plant growth* From As/. Zb., Bid. 1962* Afaetr. No. for aoodecapttatad eolcepilM Is nttr sad lor decapitated ona 15GI. CA is 0il5 me* indobivuc add (I)/l. Tht decreased growth oI * Growth ef plants fumigated with ntottri and mntsnlM tarried cciapptilo to act due to the beading*dace the tame feds, hydrocarbon gase* aad thlr deritidfa*. Walter W. Heck and to ctaarrprt when borisimtal uokoptlk* arc prevented from curr Gtaald Finn. Trias Atr. Expt. Sin* bliss. Pud. MP-60J* 12 ier irotroplrolly by ravening them mry 10 mis. Tbe abort pp41962). Young* rapidly growing pleats of fpecio known to rtmatu wa* on (and la tb 0.1 mg. 1/1. sols. A gmrity- differ wklely k their susceptilality to gas injury were fumigated jedscad dame of the amda transport to ptumiud at a poetibk b under controlled conditions for periods up to 7 days with several explanation of the iciarded growth ol horuoatnl coimptika. gase* at eoaens. from 10 to 1000 p.p^n. Tbe plant* were then Frans Bid. Ahstr. 36* Abotr. No. 28397(1061). CA removed to normal greenhouse condition* end observed for Figment toennka ia cUavdift dsocMOOtoca* F. V. J. immediate and later signs of injury. At 1000 p.p.m.* 1^-buta Teak (Unto, Btrmmgham, Engl.jT^ Biatkcm. J, 85, 10(1962). diene. butane* 1-butene* isobutane* isobutylene* methane* and Fbomotact yield of inactive algae and chloroplast prepna. wa* propane gave some sign* of injury with cotton* conpca** and tiablad at Irigh rntoidrim of exdtiag light* The intensity de--- tomato. Ethane* ccntg. 3% ethylene* and the Wow-sff gas from pmdencr cas be related quant, to the efficiency of cuagj transfer a polyethylene industrial plant* cotttf. ethylene and propylene, to trapping ccsten is the chlorophyll matrix. Ia pbotoebem. caused moderate injury. Five gases, tested at IQQaad JOp.p.tn., active pnpa, very much frtater ktenaitka acre ftqiiiwd to pnv dace the opper limiting value of fioovencence yield* while rela tively low light intensity (50 ergs/sq. on.) prodneed a definite mail inounac from tb mm. value. Tbe yield increase was ' wuvekotUi dependant aod had a max. value of 20%. Chloro phyll a flucreacenoe* excited by lifbt of wavekeeth 685 tea, was to decreasing order of injury were ethylene, acetylene, prapykoe. ethylene oxide, and vinyl chloride. Of these only ethylene to likely to occur to an injurious quantity, Cthykoe oxide was lethal at 1000 p.p-m.* but stimulated tbe growth of tome plants at 10 p.p.m. T. G, Phillips The steroid compound* ef SoUnum Uetoiatum. Preliminary by lifbt acleetirely absorbed by the iceowy pigments. report. Pal Bite, Lasxlo Jokay, and Lili Potigracs-Sterk (For- The enhancement epeetram la Qkrdfa and apioach chloroplasts chungsxnst. Pharm. Ind.. Budapest). Ada Ckim. Asad. Ssi. bowed sharp peak* at 470and 65Qm#i with a shoulder at 67D mo* _ IJumg, $4, 303-f(1902Xn German). Prom the roots ef S. Tbe fluorescence srmitired by tbe acirsaxy pigment was ro- iarintatum were isolated, in addn. to solosonine and traces sola* doeed by 20% by radiation at 685 ma* The change* in yield took aargine* 2 hitherto unreported aliastowlal glycoside* designated place with a time const, of 2 see. at 18* aod were abolished by as (l) and solxnidintoe* whose agiycon was solaao* wrthaa dories.* -ptmiai>*Kw>u"*i CJT, aod the absence of Cl" dine. 1 rmyttd- from 60% aq. MeiCO bad llo "45-8* (c 1* ad pyrophosphate km*. Accompanying fltaoraacmice chances* MeOH). The sugar portion of I consisted of 2 moles giucose, 1 cytochrome reduction to sensitized by the srremory pigment, d mole galactose, and 1 mole rhantnose. A new thin-layer chnn wbUe chlorophyll a eemitixe* cytochrome oxidn. It to suggested matogmphic procedure was developed for the detn. of nlkmkidal that In Qtoeetf* and spinach chkroplasts 2 fluorescent photic gl)<coside* and aglyvon* of the W*siim type. Tbe glycosides them, systems east* one haring emission max. at 682 m* contg. were chromatographed (5 hn.) on a silk* gel*?ypmia layer with chtoropbyU b and the other with absorption max. at 670 m#i but BuOH satd. with HaO, while aglytons were chromatorinphed without the band ehamctmtic of chlorophyll a in tbe blue spec- _ (1 hr.) on an AbQrgypmis layer with CHC1,. CHClj-SbCU tvml region. Tbeother system contains chlorophyll a with a lower was used as developer. WilUam Broker flnmnscnoee yield nod emienon max. at longer wavelengths. TmciUnins m etiolated plant* of Lathynw tingitaime. J. Roland F. Beers, Jr. Przybytoka (Polska Aksd. Sauk, Poznan, Poland). Ada Sac. Cjlothmnkal etudks of the development of polka crams ht Botau. Pdan. 51* 4?l-68(19iIk2Xin English). Tbigitanine (I) com plants with the Texas and Moldavian types of cytoplasmic was a dominant free amino arid in the etiolated leave* of L. maW sterility. G* K. Alimov*. Betas. Zk. 47, 1522-7(1962). * iintiianui. The evidence is presented that 1 plays an important The material was fixed with 80% ale. and formalin. Deoxynbo* role in detoxication of NH and in tbe storage of amino group** nuriaeadd (ONA) was detected Iq the oosaeectkn by the Feul- and mav be also involved in N* transport. K. Bojanowska gtn test; DMA and ribooudesc add (RNA) were stained by The Peraelk quertiaa group in North America. William L. methyl gieco-pyroiimc. The disturbance of the development of Culberson (Duke Univ.* Durham, N.C.). Am. J. Botany 48, tbe microspore begms sometime after meioais. The first signs of ift#-74( 1961). A study of the morphology and lichen chemistry illniiiMlIie of the Texas type to noted at the uninuclear stage~ of tbe North American members of the l*. purdu complex of the mkrospore, at the period of vacuolization of the cytoplasm leads to the recognition of 5 species: P. quercina (California), P. and marked decnasc of the RNA and protein contents. The rermota (Mexico), P. cwr/oedrrota (southeastern United State*). degeneration of the Mokavo type to noted only at tbe bicellular P. [Oiirina (eastern North America), and P. livida (eastern and stage of the pollen grain* at the time of increasing synthesis of south central United States). All specie* produce the deptide RNA* pcotrin, and polysaccharide. Miriam Hay * atmnerin. P. qvtrcuta and P. canfaedsrata also produce the (top rtnenhoflnc--e isomerase activity k ceQokr development. 1 side lecanoric acil. end the closely related P. corenata produce* John Kent Bryan (Unix, of Texas, Austin). Unit. Uicnfdms gyrophoric acid, chemically similar to lecanorie acid. P. tat- (Ann Arbor* Midi.), Order if#. 62-482$* 88 pp.; Dissendttm biua contains a previously reported but chemically unknown dep Ahtr, 21* 1503(1962). CA ride, the aliphatic tritcrpciic zcoriu* and an unidentified yellow The mkhnam ktetceUnkr space COt concentration of malm pigment and is thus rhcmknlly very distinct from P. tmda which Isneea aod Its kfimnee on stomata! movements. Hans Meid*^ produces an unknown substance reported here for the first time. ucrfUoiv. Natal, Pietermaritzburg, ft. Africa). J. Expti. Botany From Bid. Abitr. 36, Abitr. No. 31998(1961). CA IS, 284-93(1062); cf. ibid. 12, 400(1961). teavea of Za mayt Physical-chemical studio* of specio* of Capakua. I. Ab are capable of exhausting atm. CO* contest to zero coeoi. at sorption spectra of the carotenoids in tbe ultraviolet. J. Sancho 20* with a light intensity of 100 ft.^andlea and at 30* with 500 and F. Navarro. Anakt Rtul Scc. Fapan. Fit. Quim. (Madrid), ft^eandls. HsO strain showed a permanent aftereffect of this Scr. B 58. 565-70(1962); cf. Cholnoky, to ef.. CA $3* 634U. property. Stomata! conductance measuremenu showed that 9 Nine c*rolcnoid components were obtained from chromatog the mails stomata art sensitive to CO? ennens. of 9*100 p.pjb., a raphy of petr. ether exts- of paprika on alumina. The oltro- limimsisnu not yet reported for other leaves. viokt spcriral characteristic* and extinction value* wire detd. Martin Jorobson One of the component* reported earlier was found to be identical Permaabfiity of plant call protoplasm at different pH valnes. 2. V. Tntninaaad G. N* Syasina. Sb. Santhn^Ttkh. Inst. Sd**k^Kks.r Leningrad 1961* with vtohuanthin. 11. Peptr chromatography cf the amino F. Navarro, A. Rndnguex, and J. itonebo. Ibid. 571--t. The amino acids of grewi pepper* and m n^pnka represent about 2fK2. Leaves of onwest rod clover grown on poditdic soil and 2% of the dry wt. Of 14 amino arid* found to green pepper*, leaves and roots of 15-day sprouts of barky and wlieat grown asparagine, cttftillift*, and serine account for over 0% of the to water cultures at pH 4.5 and 6.0 were used in the expU. A wt. In paprika asparagine represent* 30%, and proline 14r<. of 0.6-f. sample of fresh leaves and roots was placed to flasks contg* the 10 amino acids reported. K. T. Ree*e double-dutd. H*0 for 24 hr*, at Hk!9*, At the bepnatof of the A Carotenoid* in DeJooix regia flower. F, B. Jungalwala and period of development an arid reactkm of the medium caused a II. R. Cam* (Indian Inst. Sri., I)sogalore, India). Btctkcm, J demcase to the protoplasm permeability of clover leaves: in 85, 1-8(1062). A rnmrurattve studv of the carotenoids present subsequent developmental pluses the permeability increased to vinous Aural (tarts of P. ret** has been made to gmto tofonna- more rapidly than for clover leaves grown ou lime soil. An acid ion sbfUt the UgneMi and role of ramtcsoidl in the flower. msdium also caused a decrease iu protoplasm prrtnrwUlity dur* 'The qual. and quant, ilutribatum of carotomuds wa* scadrof by h': i -- -rA VZ , : 'i WWBF -a - -:-i .. P j . -wi ".J t' r* J*v - *+'m *-> -' j> . Oil 3-y; 6 mo <5- r-f*J'-r.-C ~yik ^Wsv.* Zt'ZJ 03 "-d >*^SW *"'V - ,,* ~ w* ': v.71 ?: ';-~f v:';3':3 -fa -- z. -i-i jrr:ssr<?j> US Clniwf AhtmOt *140 S8 7s-Ksnaofs invkivsBir n fllddil and srarirhfal ictWqr im lahartfary end JfAumMmta was highly mwitf but Pytkium and pMMUi of ViaMki or 10,468 RP, i now nhsepbslo 4 were very mweptibie to it. Ernest (J. Jiwmlo --ear with roiTiii idfily. J. Dnsoni. J. FvumI, ud J. Effect of soma hmptidxl treatments oo [Moe| mold of tobacco Mtttvir (fete. Rhtmi Poulenc, Nicola* Griltet Cattit, Yttry- io the Aald. A. Trwvckt and C. Scucky (Kevh. Atnawniqw wrtktoi. France). Phyhd.-PkytafiMrm. 11, lOT-lrVIOtEl). Sta. Itatteok^k Vegvtafc, Colmar. Franca), Re*. Imier.t Tehee* VamidothRm <r W,466 HP it <Mc6)tP(0)SCHiCH.SCH(Uej- 37, IWA-2ui>. XHUW2). Diffrat (ungiridn wren triad la field CONHMt (I), X twain of a racemic nrixt. of 2 women ud cxpu. lor control id Prmmpf taAucia*. Triad at ptmwnitic I* a mazy white aodd with aa alMaraww odor; it soften* at about-- sprays were numb (1), uscta (11), cmpun, dichkme, phaltan, 40*. II it froililj ail in nrr anl i ntr anl In ~nrr mil h rnlr streptomycin, Tereaiviycui, CuQCh. mad (crbam (1X1). 1, II, jifblj sol. b tyclohuaM and petr. ether* I it ao insecticide and 111 were alw tied u dusu. Application o! dwU wit nm u a eery spudfic activity against greenfly and ** dunetowd effective than oi nnyi* 1 and 11 provided the best control, with by the roniiiViahb panwtwa ia the treated pluitt at a high 1 being slightly superior. None of the fungicide* provided aba, toafcfty aome 5-15 time* that of panthioo. By chromatography . control A. M. Gottacbo of plant axis. it*was poawhla to demonstrate the presence ol the Field trial* of the coatrel of potato scab and black scurf. M* amwwdnf aulfoxide (ll.ft/S HP) (0) but aoi tbe cuneepood- Mygiad. Tidttkr, Pknieed 06, t^-17(l(NU). The effect of bkf auifooe. Q baa apparently aniltf pentstnnee aa that of 1 but CC4N0t (I) on the title diaeaaes an investigated in field triaii b twin aa toxic. Atropine ia aa antidote to 1 but *-pyndine- in different pirti ol Denmark, both with 1 atone and with I ahtrmmr mfthsnrnilfnnsir ft prTfmrtl M. J. Ctrees mixed with (NHhSO or urea. A prepo. eontg, C0?7 1 reduced The nunLai Tfflrienrj of Vamidothiea (10,468 XP), a now--praato scab by u*ie ball t<* two thirds and black v^irf considerably ayMnaw fnesrrirH* and acaridd*. L, Bargaud and M. Ceacac *hen "*d at the dotage oI 10U kg./ha. Akxandtf Senning (Sue. Rhone Poulenc Exptl. Sta., Emcrainvitle. France). Pky* Nicotine compound* a* iaaectkidea. I* Relation of fttnetor* timt.-Pkyipffhmn*. 11, 117-28(190*'). VaiwkJothioo JI0.4A8 RP to toxicity. Ixuni Yamamoto, Itidco JCamimurx, K>*o \ama- or V^2*dimethyl .6*<0,0*dimethyUhk>lopliosphoryl)-;t-thia- HM>to, Sttrvku Sakai, and Maaayodu Cmia (Tokyo Agr. Univ.j. valeramidel (I) waa studied m tbe field over * period of 3 yean. Atr. Bid* Ckrm. (Tokyo) 36, 7(hi-10(UW2). Imcctiadal ac* Z was cMenttalty active againtt sucking paraiitu and ^as a * fivif" d fcversJ nicotifie cotapils. was detd. The l^vkiiy of 5* ronarkably efficient aphadde and acaiiicidc with pcrvbtence of awhyliwniiwtine was similar to that of nicotine. Tbe essential 20-40 days. A single treatment at a dose of SO g./bl* protects a moiety for toxicity in mcotinoids was cm^dcrel to be the 3- enp throughout 1 season. I had no activity against the biting pyndylmcthylamine group, t hfch is highly basic-, pKa' * 7.4- kasacta. U, j. Groves 9.0, sad contains ammo N\ Toxie aicotiae cooipds. were gen- CMtroi ct tmfmr bMt iUmiwi in rtlim bMt-fi.wm 2. A. Foihir. Dcaluk. N*ml, i Ptml-. Opyt. ft SrtUmttlrm (Uwr: Gofc In.. Sd'ikoklw. Lit.) Si. 1961, 364-. Fee anl of black m. Mac maid, ud nut ol aio* beet* tbe xed> u mted with 4-4 k. TMTD/loo. Spra>1n, 2 nr 3 tiraa at phyol. pH. T. Kooo . TTMtto*ial wlil a bwtlt. AlphitoMa, J- Do--rtUAmt / tauetOr *F|A1 Mlutfin* of a * noineUtil. ml. 1`. S, Hewlett trwtlnfemii- uoo.Let'., Skw,b. Eol.i. dm. Afpl. But. . JJ5-49< 1K). wkb 1% L<wb V 0.4':; Ca uyeblaride m effective .(.ixm luf . * TM *7?'SL TM <* ommcuteUe with nattk. Anna milldew cnllmdel ud Dowd. S ud Cs ty>lv- d O.CK-0.10 *1. dncwol DDT. dwldnn, .Ucthnn, or -v*leryl-l,3- --ifcf. n, i fmm Btf. ih.. Kiim. 1M1. Abetr. No. induediooe (a-velmw) in Siwii Ritrile IT mineral oil ln. The .' CA tououiu mppeend loirt by contact only: none induced *P- _____ii-.i Mttnl w URUM leeMpet in nnr bem*. prw"b,t hypmetivity. Fee DDT aod ellcthrin the coeff. for ttnvSJnx "uwUB oISiTw iSJ/S regression on kg concn. was significantly higher than that oq 2* M i^f^PVAn S!lt!d*&i2fSr* kork'vpjllfW<% rol*; for dieWnn lhe difference wa* am significont, and for a-vakwie the results were variable. Susceptible strains of houw Cswaspwa baf wpnt caa tw mmirollcd by spra>iag with maneb or aabatt. Tbe nmaeb spray treatment gave better yields and better lcafapot control than nabum. Addnl. soil N caused a mb. reran ia per cent wgar and purity tbe kaf<spot disease. and did not help the plants to J.L. tapuck *> flies appeared to be more susceptible titan A. tovt'caJai to DDT, die{drifi, and allethnn. Ma*tin Jacobson Improvement of thia4*y*r ehromstofrxphy of poatscbloro- phenol in contact Insecticidct. Ifanx Joachim WUowits. Ckemtker 2tf, $6, SlS-1<j(Hhi3). lkcntachlr>i>phcnol can be chrovnatiigraphnl on acidic layers without interfering tails by Fnagteatk acdvfty f nroasatk diamfcfiaes. If, S. Andletgh umg -s eluants CHi and CHClii thereby w|m> from ctmtact (S. M. S. Med. Coll., Jaipur, India). J. Jmdmm Med, A net. inurtvidn is rlTwtol. In aildfi., with hexane a* iluant penta- 39, 146-70937). Hydroxystilbamidine iatJtimaK and 4,4'- rh}Mn*pbcm>l, DDT, and the i+Meric hcxachlorucyclohexancs si.wUMiip).dfyi.i^ dihydrochionde were effective fungi- (op. the mseriiicfclal -y-ssomcr) can be identified in the presence C. R. Raha -- of each iher in the ume anal. run. Eugene E. Gsnsel FunglcWal activity of air passed through cohnnna of soil treated Use of phorate sad TN-iyitoA for potato insect control and a rich fungicide*. |3. E. Miuioccke, K. H. D>vnich. ami J, W. study of factors w.hi.ch..in.fluence phorate absorption by plants and Eckert (t'niv. of California, Riverside). Phyinfutk*dety 53. foes in the toil. Richard ^Itrldon I'attcrwiit (Orrsctl I'mv., 129b-l2Q6fl9G{). Funptosicity *4 volatile effluents from Ittiaca, V.\M. ( air. Sfkr^fdmt (Ann Arbor, Mich.), Order eohinmi of ami (36* t peat nwwa, 30* i Daklcy loamy sand) treated / AV 62"50&5, Idl pp.; DisterWum Abiir. 3J, 1471-2(1963). witb fungicides was detd. and c**r*lated with chem. and ph>w. ' CA miwffnii iits of the gaaewus products, \fyreihetimm wrrarcMo Control of beet fleas in brigstable beet plantation* of Kirgizia Spores ow tilter^iopcr disks and Mkiu*t*mta tdani and P-ythium and Kazakhstan. F. 1. Maikov. UetfuA, Xauki i Petedm. mtiimwm growing on pDitic fnen cylinders were iktveml oa a fm sVi/<ir4iiiv (Mtaoiw: (mh. Inf. Scl'ikoklux. Lit.) Sb. wbu and held in the effluent atr stream to assay fungit.niriiy. tool. .`trvw;(t r<mvfer< (33^7) <4 rdychlorofnncnc, polychkwiw Data were bawd on pexRiwe w abienct of fungus growth fromu-camphenc, am! vhbwcwthcne 4- DDT (3.S-4.H kg./ha.), 30% the iuncuhtm nmm when lulraquently placed on pntato-de- DI>|> (;u-4.3 kg./ha.), 10( hexachtor (4.5-<).0 kg./ha.}, and trose agar. Effort was made to trap only those effluents which 4.V, pvrthane O'!*' kg./lia.) are used for flea control. Control were fuagitoxic, although products produced hy tilt fungicides <4 wveri* nffcnng habitatkm to fleas it of great importance. (CSi,H) were trapped. The yax scraMnng xtlni. were namd. Frms Ref. 2k,, A'Aim. Ioof, Afotr. No. I0LI7-I. CA with a DK-2 revnrdmg spectrophotometer. CHN`CS was 'VTHoees and death in calves htdoced by treatments with aya- as its faensytthanurea deriv, by ttsmg idfrarvd and gj\Jrttime tnaeciRidcs for the control of cattls grubs. Donald K, riwomotogratdiac techoiques. All compdt. with low vatSrharff. (i. A. M. hhannan. aod Paul Ludwig (Montana State premies in ab< suspessnot or sulm. (raptan, futham, pmtir- Coll., Hoicinan). J, .fm. Vet, Aird. Assee, 141. 3K!-7(|M2). chlnrunitrobcnnetie, and zraebl did not produce fuagitoxic vapom An cipt. using 44rh4wirl.2<dilflrnplicityl methyl itiethylplvrs- in the suit. Those with higher vapor pressures w which raadi% phoramnlale < control cuttle grub vnufinued the conrlusinn that deeompd. in eoib to vaporous substance* (Mylone, \apam, sndV iCticss in calves induced by treating with systemic mwciiride* Plsops 15) produced fungitoxic vapors, lltS was ihk m diet m> milt from toxicity of the insecticides but is a true side covered from soil treated with xalwn, captan. or thiram; hut it effect resulting from the death of the grubs. Rachel Brown was detected from Mytone-treated wnl. CS* vat cvpwHisly Fimgicidai and insecticidal activity of some organic fluorine produced from soil treated with nabam, and, to a lesser degree, compoiads containing aryloxy, benzamido. acetamido, and thia- rrnm anil treated with thiram and atiieh. Tlie volatile toxh'ant sole system*. K. C. Jtwlii, S. Oiri, and S. C. fiahet (lrniv. from Mylmw and Vapam-treatvd mil was CHN`CS. Close cot- (wnaklipur;. J. Oet imd. Pei. (Itidia) 2tC, 313-17(1063). relation was ubtained lietwcro ifie releare of Ctfi.VCS and the Forty-'even trg. V ovnpdi. iviniririsiug ffuoru aryloxy acids and fuogitoxirity of the efllurot air stream. Also, the reactmti of tlwtr llg and Aitiule <lcnvs., .Y-subsiituted fluorobrntaitiiiies, Yapam and Mylooe in tl was simitar t<r pure CJliNCS when it and J-arvtammu lutaiitutnl ihiituln swramspl for fungiciilal was added to tbe soil. Tlic voUttk toxicant fnen Itanogeii 15 activity aftanut Alttrnufm* sdam, ViTule a no. uf coni(Kfs. ex was not Identified, but it Was kmg lasting and unusual in that hibit auiWuogal activity at higlicr cmucas., all the cum|>ds. with w- !U S` t- V' 1 IM ' - k - *3 - .. it- * - ,\ *j : ' r::.. .. - .: ' ----- ` ' - ' . r.- i---- -i -1 -i- rtPr.-? ,^,'x: .-j.- m. ; :-.d -va :,f-3 R&S 131208 do. 5^'5^7/^ J V:4.` -. 7 ^,-C---'^-;/-v' . -'-. JS 'jHy;-- V--> .'^ * ^/."?-- :i'-"-'* f'-*Sv!-^:TVi'A"f '/ - . ' - - <-*7i i -- -C'r''? , H- WlT^A- 'Z,4 aw'i^iniartikfe^-- '/.' -r '1 ,' f , _i.'*_, _, J .- <,; , . ir - a " i--i,," >,1 - --*>41] |J.,.'iT J _1L - *-*. , ru-j'^7:'"i -T 7^:^v/'J'Jrv-^ v- U".-- .- '.1 t/*- ^rr --5 ..r'i * ^ '"Jv V-* . Z. ydf T"C ^ V'; - r o.. s, >" -; '. 1*.: - > "^.v a 7v, ^ '..VV" . ^.-y`V -1 ' ,- " -- . , '2, -'/-, ^v*",- V f* ' ^ -r:'V:-v-'-r;.v .; ^ v'-. `.' ': "J"' ".11 ' -i iC.-*~ *s. 'V jfc'. -v --fe*.^rvlv'^>:rV.5 "- --^^5 .TOWi* , * ** L >' _n- V*' <; -.' 1 ^ *.,Yv',7. -V, - `,, ^vV'r - M ^-7;*'*. "r }r 4. ^ jT ,^s^. -* ,'",i'i.'v*yT - .* -,.''C*.-v--'--"!<t;/_->F*3S-<_AJ S7I1 $712 VoTAO tadwd r ft pit N MI !i t* luci'<-4tM- lit rf (MM. dlH X M* * W, 4im1 |l i* rfli\ u r jf ii*l | m mi* "I <' dlwill. Tin liHltW'KUil .irllitti < i n*v..i j* Hi `Ilf 'I* tl>4 ffinni.. I hr f*viil *! miil.ni. .mJ t' |)J >J ti*.i ,i:r.n,t I hr Imifinttal jrhmi ra% r^i'tintj h\ li.v tiut<u<. diin. ( vvitil k(mt* Mirii . -lum. i .it:--!mlf4if, ,*tni i*l\ tijrdrir air. 11m iin'irTtitr rttm, li miiff !wi|>|t >(*> jlirc V*wilar( with tlw ami iur .1 hr\, l-uithrrnmrr feimi ihr it'I* <( Ihr i*t*nMfi wrTr i*wt t`K|**wt! ( <-Ji>r^!ir a< ui. i( iuniunl.t1 activily vt mil 4H(Ttl Ii\ maniimi it.im with lit*' J until * M, W i hlv Tb rflrtt of Mfn* (ua^icidrt oo Euroffraji mi tniir popwl* ttau la Mats*. 1.. \\ lUMii.iufitf i.M.imh' Aft l''pt. >i.i , OnifUlh Jt />*. Kmjtmuj, V*l'* ,(.k I'Hh'l lu tiuU rnwlurtwl in Mamr (rum 1W.V< (IumuxIi i'*'J. Klimlm lit*, nhihitrd an itnirimiai rfift-i mi Mri.itrit in v. Ami m.'hii, lhru-*>f Vinmik (uttfimlt^ m mammal |r*i|tT,*iiix. tr..m uhirh .<il nivru (ilki littl (mil Jficnaltr wcrr txrhi.Usl. m mhvl .uti.ilh (aim mile tNipulatMU1* in Klv*aiui-iu`ai*`ii j> >i<*. m I i>ui ( " a* Cimiiiarnl midi tln*^ ui whii li -,ipi.iit *hltm <ih-hi >) (uanidinr), Xiarklr A m M. and Ihu.im mn m^I. In tin (%( nrcliard, ihr jlu*st ciuitiiWir Urk <>( milt - .tnl uiM'rt- jn* <i.tt*-rv on At. ulmt makos it uulikrK th.it tlti^ n.ttuf:il vmui>*| .ijcints trrrr fmtmn^ihlc for tlir tnlit, ut tn*'*. <( (*ti\tfi>h.iami^ iiiiI' h i<I>> arrvrri in |l*r flvmlin trratmrui'* Imiii itimi*. .in* Hmi l(< - qurot a|)|ilK*attom> il (lu- fungicUk .<ri- m n >^*rv tn % IT i-t >n i|> prrriabk rtHiuriinti ut tlir total Kun|H.m imI iuim- | i<tu..n.n l<CIS A oev grernlioue trctutiqu* f*r vaiu*(idK fungicideti for con trol of cotton torc-abui. li.im M I ^ml .mil J U Simlut (Lirut%Lina Stair l'im,( |<it-.n Khuk I'tin; /)t*r.<<r 40, K.1J titlfltiJl A w tixhnO|U( int. h mnul.iti-i I" I*! '- liitimh Ity fyljciUf irlinliil vn1 tin i ^ ( (rv.itnl -**vt w.n (mind rdrttivr mi mn'tiitin I1' ^-il i*' *- in Imin -U.mi- Mffihntl ami m*fi**<f rih/oi -am' J'cm l4,. .mirnln , ' (jtt tbc nun* tlfHtiraltir rt^i.t*. tnJ>ut\ltir i>i<<<tih < f ahtnylanimr rtln U n-okHir t l m->.m < I l Cltir't- ScftoO MtU with lettrii Utirciictdt^ *nf <on'rni pf F.pic^u'i tomrio h | k.ni i.j m.:; r - ,K . (Hll. Iltit., Mn 1'iuLt. |i; /: htif- ' \ -I 20. I.Vr ti.'|r M*ij, Ir%t* *it , * (htnuuk mmih-r (< u a* i tt-< <th i h . t .r ' '? Hit fmirttiri*. <(* ajt* ! ..* taumi i<M*nnf ir.^ wrtutiiat1 h F *ii r t i /- ImW 41, M` hl>b-. /olliti it . -'-i > (tM Ct* lr , rp#t*Vlt -fltT t .' I t r .'ll fjwnl |Sa uw it* *. . * Hlt .*!# kot*arhi w I V#. t i>m * \ ., 1 * . * Foiflol *t V. , .* 4 * * M n , .' t *1. r iHfttrVr* * 's,, Iuv*.^ ; , >.#. . j.s da* Ilf *., MU . * V - M^ |ai4h** 4m w i;a*vWi i r * ii * * ^i * i '* i A > v/v^ if i * tn vfV 7" 4 *' Claimnl \ai fr%t*lur% f CIICI rr pfi-lurrH mi Irt* qtinAtltko <(iu t i iin;iMinl HvlituifcifV and i(t iKrfWiiM imHIh> w Fr*on kr` /k . kk. toc^. Alnlf. N* U.lL&'i. MVKK Ciumi ! ulifil funhlitf Is tinkct .X. Dotocroot |roo*r* ti* of Mmr ibrrt rtngtd corhoiytic tod htttfomUc mWuac** to the luhtrftiono iremit*. NtnultmH ittiont. 1** Hod* ini?i ai.tl F ) ltiv C.S I K.O. Ihv. K..rru l*nal.. Mrltammel. *4.*i.f |7. 21 .^I'.aWiXwi Kncli%hi: rf. (.74 51. Ill'll*. Aik.ut jo inthr-uauf*, authfonn, aniluiiqyiimfit%.ami \anlhor% airr i. v(t,i |,tr thru jntittrmilM* action, amt the fnulli are pvt* m term* ol the nuirn*.. unnl ami tlir trrimte survival. Many of thi'H oantaU.. .ilthiiugh nmiloktc to (be tmn<tr\t**r4Mily alightly invH'i. wrvnl cfhctitrU a> tremitr ilrtrtrm<. <s|, in nwa. *f t AittiiiiKtnii i which may \w a naphth>a|MMMlyt|iytinrl |ii.iiiil to tic j tliirrtnU. whrnji rulimfuarm fa tuphlhk i\r.*uri aa<* iw-itivtivr. An inctrair in the irt|(h *4 * ijinple .ilk\I >>r ,ilLo Miliktiturni in thf *-po^itn*n of inthnim i* .intlir.iqmii'Miv r-iiiMil im a|>i*e*fMllr change hi antitremiitc at* I tv it n . Wiit'ii ihr no. of %ulMitnmt Oil gvoupt vm ukiiimi, ihr -i;itMi ongmallv hv the parent com|aU. (etnletl It* divrt .1*1 XI. Some teats oo ih* (u&gi loudty of Md vitrac* tier* an>1 icUted compooAda. I*. Hutlman. fhf. M T. Ki ll n'tiv k from khdI amt (hiik, av well u t^vefal nan. futtgirvlro, *irt- rt.uinl lr tlieir unttfungal activity in a wood mtanitr tUi.irtht iri-i' F.Miulyptm* (((Riim vtardiM I. The fungi Mini uirr ('<>tii<riiifii nfiMira, /.fMini Itptdtm i. Lmitltt fraAna, uwl / ..'m AUtut fit extractive* acre evamd. They in- ' luihit lirurifie di-fivx <4 varnui* tyir*. Ltpaehin*tne (X). qui* ii..fu-*. i*imti irtit* U<. *tiUa,m'N, tfM|a*kine* (IXX), anthocvamlitis. li.itHiciiU, hgii.10*.. adium, tmietuu, ami >hikiinic uchl. 1 uni HI <;i v**tt\|o|-. i |irtved iiuir to the fungi. A no. of Q \ re toxii-1 *.p. to l.mlimn" ami l.rnzitts, StiUiene* were nut very imir, .no! iivniiii|iK 14ml related etfUftdn. f proved mmtoiic. I hr timtnl'Utfio of certaiu of the hrartwnd evtt. tn decay n -.hi.imr t/r ih-4'UkHt'd. I^Miii R, Wile Naluril lyncrgitti for in**cticid*a. Kytihei Vamadiita [ I'oiv, l.'.kM'i. \i//-* lipri Kdgaku Katik1 14, A2ft AZIWIMMI). A vtu it) t7 rrfrmiiTv, S. Katenmur* Sirreirnif: of fumigant* foi toiicity to *u* tad Urea* of th* unr/Vil fruit dy and Mediterranean fruit Ay. Arthur K. Bur- 'C If f , j-;k flniiii.in, ami ,1*4)11 \V. Halurk (I'.S. Dept, ' v,'r . H.:v>hdii, Hawaii 1. J. Enli*mpl. S4t3f. 'Jtll fi vt ihi iiiiritliul and right co?U|>d>. and miiti. were evalu- .1-.I 1. imnu.iuf- for egg> ami larvae of the oriental fruit fly ft >> rhr-c t^.mptU, 4nd iuixi. |tlu tlmM: previ- . i.v\ (X i't: iit-l ag ittv*t thi- mart l*ug the total to In ,i.U" . it.1 < f 11,% jU-xi itiu|dx. and midi, wen* evaluated a* i,i,"*/i .1* (* iggk jud l.trvae of tin Mediterranean fruit fly ( "*'1.' . ,M.iim.dk lot*' to one i|ircie were gen* ir4'* 1 ., (. ih*- othtr of the hafogenated eitert. ethers, it. .M li . v /.a*- highef than ^11 mg.fl. f<*r both eggs * , *n th* tot it *4 .Ui dtrni ntnipd*. imhb. not in* .1 > .f lii.Jkt.ir. IJ1, <4 114 muihalogenated eompds, haiogeuv had valuev<4 lew* than 20 1 -r ! !) *tin I hr ran|*U. iihirI tolic to rff< *nd .. f*w* fS-H not tlx **Uln wild the tMHbhicyanate*, *U * ' *' *<. i' nft *i, 1 hiiinl |u(xt>n. kCJ5 ^41- puirvk idtrasrr of TypkMroaai fa&acis and Pfcytm ';* wok u*m abocreitmoa *a the predator eft* w l -'rtfl F SrunU. T- J licnuelietTy, and i * r* * l -' lk|i *4 \gt . Ilomtlohi, Hawaii). J. t ,'T* M 1*4 two tprnr* *4 predaceimi / . : .10 / *a<u amt /' ptunifu are important .p-'o at hv kiitr'wot* of <4*40 mite populationt. m . r> .u 1. art isr piwiiibir *4 drv*4npff an iate- - >'**< re>4*f*m lo v*dng peMindw least r - *v< ,,.h *4 >H ufwinr nontwlfcf Jimwi ,.i ' . k4tir<tw <i| pet *Wx inhti. Ik pidt* <- v ** '** *^ovr* '4 12 denifh that mrlmlrd the *> * ** w* twhn the nwinh* Amine. "ii *4 <af. and the fmgi* . i*rt *) iw*F rw watt of pian . .4 .'** uvfoifiiitA t* nk*r the nntiwi -_1. i* #i> *- 4*04 PPM'* 1 * . kvioo e**i M**iin. KCJS - i . Mn 0 siUta *t ^ im** irfiyl - ' ' ' ;.' ' -1" ' j*'--'''- r+'r- 1 *^a`nirTnni riihiirt'lHiiiTr'ri'-^r^"^ r?rx*?*r 3 i i .+ -:'.i bOii if'i'rtili`riiiir(ki)~i it-hi-'! tarn iisuaiSU 6/:f 1123^ A- 'A . -,;- : .- r.t-* - + ^ r,.-,,,..-, iS -- - r -.. -.- i ' ivA .' -;V-V J ' *--i>i:-^ O -'. --^;'%':^3 ^ ^ajafBwgr ^-: --^-i - iyyfj '*;'.'--a* w*'--^-,2-'-^3 - .::: `^^>3 -,.-,,-7_; S-.. -T.v'S,J2^a . ` ;. v'-, ' .-A-' --^rA 1 'e,,3-rT--". -X- .>. -: -':';f.f. 33 fi< CO C*J IS) o * *' (0 :^. . `"I v fc . <i \-,j 3 , ' /. 1 MtelC -'SLd ' :- * -**,./. - -, . "-J WWWWW -' - A -;,i ... 'r'- - -:-H - .'-t -'. - j.ja mu `Chemical Abstract* 11212 VoL 61 PM. filiM. f Kimthe F*4, Wmmi Kkim, Eiiol, (Mos- and lability of bond* formed by incorporation of methfmtinc and O_e-.a. Ia. d. IM. Ut.) 5k 1462, 163-4_ , D <*V* cytteinc by d*cmtn| cysteine. The nKldBim of the eiMdiart pbsnylff naphthyiaaine) (1). naphthol <U> and aniline <01) had compd*. ip ditntMed. From Rtf. Zk.* Kktm, 1964* Abur. No. L*Dmnliwd 8,28D, and3fi6 mg*Af mp.. lor an acute single 41>*A. MVftK *~^xritBWd adonstntiu it >*> cipti. Ante puaminf f Certain biochemical bidetaa of the blood in oorkort expaaad ta with!l and 111 tndttd ia * predominance d iniont of the central * tack tubaUncea (beacaoe. cfalnrobasiena. vinyl cniorida). <m system (tide position, coettnu^ut spasms, absence of SUvuimbor, Muia Lccoia*kaflii*aiid 1. Manta. Prim. Takiika/. el rd&etcs). Tb* detree d disorder of conditioned reflex { i A'/mska Prfif, ^iMnuru A`iia. Etmi. (Moscow: Cam. ltd. B pronounced in tbc case of 11. t'ndrr the Mine i bled. Ut.) 25k, >002, 2i -3, Osidative procemcs and liver fuac- a* 1 did net have a marked effect oo the central nervous i tion were studied in Ifc! workers with DDT. hdachiorocyelo-r------- In the coat of Mibecwle and ep. chronir pobonmf with i hexane, nd poly<viii>i diluride) resina who were chronically ea- t O, end (11 a fwa in the hemoglobin content and no. if | pmed to vepor* of ekbwohentene (ti, and vinyl chloride arythrorytai in the blood, which vu meet pmunnmed ui the )(U). A lerrru*e in catalase activity and increase in peroxidase Am of II and Hi* were otwiicil, Phapvytoa (Irmawl and )and iadipbrnuloiiHiim activities, and an mermse in the fluts* Ihv Irnttim on* dimM. From Krf. ZkKktm. |Oo4. ithinne level m the bt<*id were ubierved. Catalate and peroat* Afartr. X*. 61221. MVKK *<it*e were imu ttnetfly affected. Thne riungti appeared dnr* Tin MM nicdk affect af methyl akahol. T. Mtyema h inf tle first year <4 work i < U after I year 1. Random changes (Unio. Tokyo). St%$k /|aka 124-?< itaU). MeOK (10 / in the nn. of ervihrueyte* m wiwkers with C*1U* a <kenr m al* m ) M adndnitlrTed orally touoMOthctinf and rurariml ! burnmi and nwteaHr in or and >*|Mwliiu. increose in aldnjiiy flthiu under artificial ropriua, and the dec. activity uf the activity, and decrease in vohitoi drhpirnpuw activity etfi Mil eatum ayatcm waa raankil from the amyfdainel no* ; ilw idewrvrd. A ^indy <4 oxidative pnenm can give valuable ), hAppocaatpoBf and frontal com. The let chance in the * data fwducn*a*t4isrly change* From Krf.Zh.. Kktm, 1964, thuiwrui nblufTia aw itaw wnrt activity in the /nw(J ftr- .Vu. M31.1. MYKK Similar chanfea appeared ia tie amyfdjdmd nudna and Aiaganic amines, biogahic aldtkydea, and akobol. Aaron i when >8 g./kf. aa fiveit caally. Three dunce* FrlilMcin. Huit^vi i(*M|iamt. Keith Wtmf. and Harry Freeman fmindd thine men after ElOH inemtam; three <o Hit qual. iWierrMet F<nmd. he Fxptl. Hi4., Shrewsbury. Masa.K diftrtiai ei in narcotir effect bttnwa Met *11 ami EtuH. Fn (Wr. J. .Vtrifb*' .IU. 25, 2\S -*.Vl*x>4i. EtOff bhwked the CmreMi // iA3, Abur No. K.JI* l:3). TC1>\ 1`irUltfixn >4 vf**iiann-l<i'tw.VhydriixyiiidoleacTtir**4^ aeid(l). PainaAaghal nwaphnlinicai chance* af tka heart dne to cam* k'vfry f I. Uvti nx utuuiy **C. xa* 76*,. (Tww hr*, after UoadaMimattntianaf balanasMdntfamina. f^urra Kum> np*<tKi *4 ' ut )n>IJ I ffc*vrry *ji *44J-; after till tf., (Nippia l'w,, lakyu). .Vhidci /f*k Zonk* Ik. iJJO 44 37";, 4tri * ic . idi* f. SrwHiniff*Mr ainwidfml unriuU UML An run*. % made <4 mbUt hnn* Mt<NrH>| com* tawni'.l* with frier f !:(<{ ya*e .lif', of 1, 1 hr. after KtOH, hriaod m* af Salvanon and *ailaoMae 1 uUAndamtdr * The mo* .Tiir|, J hr* after. iJV'i-; 4 hi*, jttrr, 40*); and *44 hr*, afttr, onmnaat or d blah drugv cave me t mporsrdwl Ahn^h m i**4; -- *K`,. h(OH *w Veil Wtirkni imttv*amme nthUe **r aiifehydv of the ananab. TV hrme mmale uoderwmt recieu^ive rh.mcr* iblipiMpiuv, Fit ill minimum, in part, may he due to Adiaalattyar vaCiwUr dcrntitM. atth adoect ctainertvm iltvtril level* *4 l*i eigrnu: aktehyile*, Unpue aleu., w bin* ha Urn ionatao af hUrutar rbapt Mproifuf itnw eln* friiir imrnrt. H. W, (Uifilnn nnand. KaAu'K.n V**!i RmbeciNiUpf kiptalogteal studies an the liear of retain aariy IhamaipQ d W defrer af ttiwyna af cttUto **amtic tu<es af finfthtUfti;Dii*knifS feeding. \ 4it(<i Nakafutta onmpomada W oarhW. miritw |n.iktr*rr awt | . ^ir . d Mn) i_.nl .Nriffo# /fekw /idi IMll. dtf. f*m. Tduhi A*ia*4a /**. / i^ntn /;. 4.1 .<>k4 U <t> were fed a k**yif>tem diet c*tg. IMM*, ()4mv*, <M. fad Mtii. f^t. \h IMOi. *'.* *! JJr:*-n!r>*io mvthykiujMitw/idjmieiw 1., jiid in coily Mi|t*d the fcvilmg the ov laud letuwi the nt it am.rnr li ilpictiH h* IV -w- itver* mere 4n*lTr<1 lias S* *n l.iv|4. I here o a ricvftme mdmA anf the ami. U aflii(e>tdim.4 euertnf ith th* ufvtr, and tn tihmirkh 4C**t *kM' 4Ih! tne tkpev *4 I"* Rinvpiealx* into Htaici the anil W tt'Archn *11: ilatrlml (U tie amt *! kNA *' rnleml. T^err were ih thangra in the if dr* MMai iwtrirtt aith itor wue, *al iBlwmi ilv amt. uivnianptinr I'N \ *e m thr tie free if "I1 xmepeitM. f C*li*eod lHr amt *4 phrmd fulrml Mh the wtme Tiwve wa* an m jnjffilw 4iw| artifw ||yr4rw* TW rote d ttaHTtKae d 1 award t* the Uni oa* O .* i 7 n-f mly a difbt detvraw tn end **.** mpedmi Ffxm fluf. tq. <aa.-kr. nmiuiic vith <Oiyee >m <hr temp od m.**tu#r frua*. |-.l; ICCV* OM d the dn \ f* U ani C*H* thn i^atr a# o ^ .1 .'and Cotanewai tatwttr mhttm af Air Fano fmhpmut mm 04. mp idtirtoieac nith iwrrae m dm trtci . Is r temli IV \f.-m* t > vUn*ki and kifl 1. lUleirl t lad. aat. Du! the atMartrd I |xieitaUi> ot i thr |*u,r. He4 km tt rrMm| . Inc . l`*uUlelpbu. I*a i. t'Ji, ttrikneif t Itknuibtien^nfaiir) irri Ix^ui ur.iiiif- 1'tft i *. ''A.f tr,h Nrer . At* 265.460. h pp. . IWll. flomg thr drgrvt d riia^rv aletm| d>m i f..aiU4 tr Twelwv milriuit were viiadwd *u the |MU|)*rMc patch tn4 mr maafdnhrd the rate *4 rarfrteo *4 teiai** ** *4 nrtat -i ni .4 h k} ai i ,h aAimal* anti butna wl<in14 i** drt the primary u> lour Midi tanih* lr drtd hrm K** Z4 . A'ha )a4. r** .U'fl rilnl. brtfumf eflevt. aud vpatiuirm mlet. Alkyl* AM. No hUlfi U\UK *i Ut;tMtnl wa* in> vewtr a prtourv uniini t<* test uw Caatain proMaM m carbon dianlMda io*na(c.T ^ --' i *.-iimt (>^ihtk wa a vw leuiury unuet, T k'lmii*fr;wk'aa /'tm < Amih f***^ /c* *!; .aiiet huiftui* v w(< iu uv in naun wtl ih human iafrmaN A4m./wm Im W*^t l lUO* >km kr-an t N i..vf Afi A'/ft J7 l'. "fr IVStJi. fCV H Iff (V. f.ipd aMnoh riiili M leva iMiawaili njpi^ii i< TW ikettpeunc s lxpUbil>:y af espennuntal hear orrhoaia in iwernul a tajarta* uf *Z*iCh mtiavraMmii 1 w i the rat 11 Thiosceuami# tirikoaia <n the rat and the thriuwen loot m the Inti. kdnyi. ban. tone1, bam tn-att. m<.*. .cv f f>ue:rtHwJj nJroceoa. and inlbatairude. 1`, km-Mcrt, rOhiii^to *o e%mi'*drthiy htgOct tiwu *n the o.nn.4 II.*- ) . \>4tv. II . V Km lid. .n*J a CmtUlrMl Me|. l utv. Kbn,, Ia miatrnt m the Hibet oar lie uw* a ibr omit'4 f- nr. hnt>r|. / k>* ATM*' iff. Ilk'w. 4M1 tMlkdiiKn torn of la %ith thr mar and (ten aaa ah-* eiltkt^iAt. *-; lu* - jrfmt' U hde uu urtt |ivtn i!tHM<et4mxh 11 milljr (175 mi the hrvt deBu after p*avtmc. rWainui .4 ia {...pipiu. t-if k| ii*uv tiult Iuh tLt'iup iixl 4<>(ti|jk|. lupnlwf iae thr Idui if nadranO tuC*,> aa*.w*' 4 luan ir >u in tite < >?**. b*er iljiiup (`,|(mneiX'**lt end anakwibc tlinmh CMPtrul- Hat* ttpml caniwvll) in CN i|mo <* ' m.wii>k **ir **immi.innl tml tie rllmt obwttnl. 1`minivtlnif ad oaccyecd Id', inv.i nu? pndikh *4 *%*i mi-ijInMin t>* thr 4%'uitt) FlrrilnJ ifimuh feduevd bnatab|y than nolnf mmh. cmeiao *4 A miriliiUki4tiniue in* iiuiteiU |nthf>Kie 1 p.aw*nitig the fimleer eh4nfvam tWltvOt fraaad at the rmpeoae id 4 drvreate in e.->rtvni <4 wr nirtal**- rri* wn* frver*dit fa chi'am* I innwaimc hsfhrr level* of Mea. In IW over na^apur ervi id if** emiunU rtr ittlk:tr<l l>itv*-*viu i S incr(i*ed mmulitv. 21 vefrrrtu.'w, Ul. Car* by Jdri TV nteha*a 4 He alam it CS; r> iti iiio*ol lit* f boo tetrachionde rurhaais in tbe rat and the tnvtapeubciafluanca hyfdheiiard that CS affect* hpul petoUfnra bttmn kt* Z*.. of CluracartKOMls with aad withwl swnuitanaona admmiatra* Aha*, ltd. AUtt. Nn M'* HW tiao ef antibiotics and androgons. k Invhcr, II. Laaff, W, Machamam af the (u kb* af tiruta thtnaaid )>A>Kti OiudlrMt. rfii.t II Kuclm. .'*> Hi. I.iref* <4 white bnw wad m indoatry l# t* luiLu. I *rm j . ut* w*tc cutlh.iv After J4 injeetiTin* 4 CCU (t><75 ml./kg.) over A'/wh ffa./aimnxaH At*. , Mmcow' <**. lul Men _ 4 l.'-avel \iUut4tir<Ri4 mjnti<m *4 prcdmwdwie or U*l 54. 1662. Ittf In tv**r fifili. *m inuij >U |>*vfp*uni i-uti'.nr prevented ttlltfljf trfrnrritno am) connective imd nith ehhirnuted hyi)aieariM** tinr^hl-^vt'V-itw I . irii^ l.in: itnui Oral i4mnic*traiH*n h.vl n*t effect. Atiminiatvaliuo rbbmpoitfw ill), irlrtrhkeohrfiiane \ 111 i. 4f.l m>o h'Vti4>c >4 - <* tre.itrd wul CCU and glactworlicoids tJ CCUI diMiikn nt iflmr)prauiiu *4 Uleinl nmnu null *:*** rnlu^nl imxuli<> hy rnlihint ixfettxxit, 30 reference*. tMur pnit*mMhvtvmte in iot>e|Maiv*n uf o**tcmr *> um> luce Gir<4 StoU prvtem aod vrum |h*Uihov. iimimv m imfejneaihin i>l (Iwint- K Differentiated determination of sUica Is the loafs of animals. *C; *hfht ihwtrder in incie|**ejlei *4 Kt**ihi<*mne) aeir i mml N I \ artiii'A* teva. AktauTo. I't-fi* (itfteay i p.pufnaaf. The vaiHmv chheio^ted cimihh. h^l ihflrtent <hAl(>ti* * t iieits /V^f/i) Pmttnn Kiev ('.<*. ltd. Mrd. Ut. I'kr. SSR) 5k. III mcftami im'iinv't'^tKei *4 cy*frmc-"A. ah the *(uiln<i lV0Jt.l` 1 !* the |Mth<>gene*i*<4 *dicif*i*l the content of Itidi were innepmilrtl ituu vmm ilhuiumt at a fa^|rr i.itr i .*n Oce .*tnJ f1**1111*1 >i<h sh**iiM be drtd. sep. A series of suck in Urn cuatruta. II) drerraied the rd> between the `.(ability espiv. wrr# r*nilm (ed with the lungs of animals dusted with clay - '-`V: n ~"v7S [A: x,'.'-m-./v4m'wsw '-**!* ' ."I .- "3 - ' *.-V . / ..:-aV .. iifci .r.i ' t' ' ' : V*^ ,?3,A ' yi.. ' 1 ; >4 L , ' i* &' it ,?;Vv^ . '>' * \-z*i. L-. ^ ; i--?' :J ; * ' '-A b2- ' bSiC b -SfSSrS If* ft"; i TOfJ said, with CO I In 10 doge tespirtag O nadev Akad, Vd., Bratislava). EodorrsitWegy 7|M1) 151-8(1965) hyperbaric onditMU. With 7% COi present in the supplied Q. (Eng), Aliyi ikMhMKYkMlr. admtoistrred in single dow of the CO was elnnuiatd nearly twice u fast ts when pure O wa* 2 U 4 mg. lifprnifd significantly the ruinwniinr uptake by rat r *7 . i -- 4 -'1 respired. Of 22 patient* with coni gae potsoamg, the teepiraiioo thyroids, The idininittratkrti ol allyl imlhiieyknitr (o rat* lor of O at 2 atm. pnmirt led to recovery!no fatalities). All pa* flu A*ft. b doses nmtpoodni| appro*, to the lul content W>ev tintt recovered nwiwmnfie 3U-U0 ni. after inhalation of O *1 mi ustard oil* in cabbage, caused change* in the tbyroul similar to r*` r"" *- - under prinurt began. Of 70 other severely cool-gassed patients, those following cabbage feeding. KCPN only 3 did not recover. The results demonstrated that hyper* Tba physiological properties of aerosol propsllant*. Hans banc O should be administered as soon as possible in CO poison* .K^uurtwblaff (i^Snpninihitmecmlimuk (t.m.b.H., Krtnfrldtn, (kt.). .A.t.r.o..t.o.l , j? lag. Data are given on 1 patient with barbiturate poisoning who /Age 9(4), 44. 47-8, 60, 9D-K IlKWK Eng). A discussion of the recovered from respiratory and cardiovascular depression under ^physiol, limits for many urwil propellants was presented, hyperbaric O when other methods failed. Other report* indicate / Rats. mice, and guinea pigs were cipno) fur 2 hrs. daily for 100 that there are no advantages in firing 0 at mare than 2 alms./ days to 0.3. J .3. and 5,0% vl. of the propellants, vinyl chloride preswire. At higher pressures, toxic effect* of 0 appear, pert (1). and mists, of trichlorufluoronielhane (II) and dichlnrodi* -'^3 haps resulting from the presence of CO in the blood. j fluoroenrthane (III) (5050 and Id 90). The animals showed no W. C. Tobie { reactions to the mist*, at any concit. or with pure I to PUfseei* of oalt poisoning in animal*. M. Bohosiewfcs b With 5% 1 the animals first sliowed increased mobility which was (Wyuu Sakola Rulnicia, Wroclaw, Poland). Ztstyiy Sauk-, then gradually reduced. Upon autopsy no histol. damage wai li`y*ittj Sikwiy Rwlwutrj HVscJowta, WV/evywsria 11(42), 3-42 seen. Mice under a plastic cover were sprayed with a shellac* (HM2KPol). Administration of high NaCl doses (3-4 g./kg.J booed hairspray with I. H, and 111 proptllanu for 30 sec. daily caused acute intoxication in mice and pigs. NaCI poisoning wag for 3 weeks at a distance of 20-23 cm. There were no histol. noted when Na* values in the brain and liver exceeded 130 tngi changes tn the lungs. The thermal dreompn. watdetd.at Ilk*)*. % and those of Cl" 180 mg. % in train, 70 mg. in muscles,^One g. I yielded 39.3 mg. CO, 11 mg. C0C1*. and 102 mg. IfClj and 230 mg. % in liver. The las* of water in brain, muscles,\ 1 f.UU.5,7 0,and W); I g. 111(1.3,2.4,70); 1 g.sym.dichkw**- and liver amounted in mice to 3.8, 7.5, and 9.2%, reap. In '*tetiaflooroethane (0.8, 12.0, 30); and I g. methylene cbluride pip this decrease in brain, muscles, and in liver amounted to (13.2.18.0,81). BK^N 4.3,9.2, and 8.7%. K. Belxecka C__a_n_c_o_a__tr_a_d_o_ti an molecu__la_r__aieves aa pthmiairy data i * Toxicity of the okaadtr laavaa. Symptoms, pathological tioa of trie* components of mine air. Jcr*y Mtuycxuk (Ghiwny anatomical damagoa, and mothada of gmcoaida identification. c Inst. Gormetw*. Kanmicr. PoUnd >- (h*. .4 oaf. i Warsaw C. E. Eliakis, b. C. Eliakis, and A. S. Coutsclinis. Awn. 9(4). 671-ttff HUH), Trace eompontnls *4 mine atr. Mich o XJed. Aegole Cnaisd,. Print Sit. TttuM. 4l(July-Aug.). CiHi. CiH*. and *-CHn. were (void, oo mol. sieve 4 3 A 367-88(1901 XPr). Dmictioos (10 130) of oleander leaves, type at 0* ant) 30* and retention tunes were measured. iTial* contg. 3 X KU~*g. of nriinui|42 X 10** g. of oieundnn. were acts of dmeptKo at 311)* were analyird m a ga* ctir**i*iqi*pb used. X/ values of O.G3-0.70 for nenio and 0.96 for rtrmrtnn with a mndurt'imetnc detector. In vme owe addal. oofs were found by means of paper cfarmnatugraphy (Whatman No. 1, wa* used. The method makes it possible to increair the sent** ascending, undirntnimusl, 3.13 EtOAc-HOAe~HiO). With tiviiy of the drtn of CtH*, C|II. and C,ll* It) H*i tunes The the same method, very ihulsr values were found for digitosin, results of the detn. of traces of gases in a sample ui mine aw aft lanatosadr* and other glwcuoadr*. No abortive effect could be given. The effect ui ctmea. an be esad- from the feteatam tvh detected <m pregnant rats. Twenty mi. of dccwctiou (coned, 2 kortsha to */*) resulted m the appearance of toxic symptoms ta nti after Penocahtlirr of at whom rat akin to a volatdo hydrosorb--. *sarf ---iSs 3)4(1 man. The oleander cmapiuimt* seem to afliet the central nervous system, cop, parts related to the tekoerphahm and cerebellum, the symptom reacrubiang those of dercrebratnio parmlysn, according to Shetrmpam, alto displaying iradracy to **Clabeled p-cymono GoiliaHinc \al*te. )m Cuban, am) jartpes lArpwvr* (far. l*Hanu.. I'ua. Cm--ft Rrmd V* AiW. 1Mi3i. W*M< 1964s Pr*. The e*w*ipd rraldf diffw) through the hawlna skm aud was drtecttd m ufi** A . ":i total W partial dwmtegnUuu of eerebelhrm. la rat*, which ,, spmalapp. wnuwd ivreeot*n> mhaUtvn*4 ii*e ape whoa rewind 3 ml. d deeurtiua mirapmiimiwlly 9 tuneest every other day. cssinuw of the parewchymslossr urgoas touk place. Damage to kidneys, liver, heart, and |unfarmnhial inflammatory mlight tneald*tv the firnaddimnggst Jw* the lue <4bln bad md yet brew Itemttl, they Uf Out mdisfotvsahbe l*e pSatfAtSW *4 a vefatde hydf.irartnm. t k I'eWa M cijngLsfmn and atcintMi of the hmgs wa* drtd. mounipnDy n*r ga* from pteati masufactwrtag ayrntbetw fatty asada and From CZIMR24), 10173, CM Irohnla t I lhibt*fskata hwsit ?vi kn iw*t Dot of tbo chachob embryo la the emey el efUtona tomciiy r lf>g., IliMv* > t w*(/ 2b 1 , l*i ipi) ikev 31. Jacqueline Vcrrett, Jean Ihetre Mnrunc, and Joseph Ur* keMilts re reiwtrd i the me^tagatiMn *4 * sanptes |Jr. (Fuud k Drug Admm., Washington. 1C ; ,Voi is March Apil ami *>72 is |urf Jsly' nJaetid ii* J. Anti* Ofr, Afr. Amuh 4f<6). HtiS-Ol IW4>. hiiimisuy m from l^iurv* iisivl( laity mi* and fails aos It ^ result* of no mvctUgmtnm of thr gemra. syueswr bumtf <4 samples n the <*prtug. > taas n>g m 1 weft iii,w (|) In ebtekrik smtayua are reported- The stndw* are detected, fait) ends. a 34', *A the samples tan** mas ,. and not etdnpfeir coougb to verify d any 1 prudnm any specihr nosald. bidnewUm, m h^i the wsii'in Rut Id mg n 4 ; pathol. lew* ui the embryo. Iiyctam of test nlai . in yew- la the summer. 7t', of the sampfes imuiad k)0swdU . pylrse glycol vehicle, were mode, bedewe lacubatwm, fertile (mas. A3 (hi mg , m.* , Cr< nutamed latti acis, and k1', \A*hite Leghorn eggs either by way d the yulk tv a# erll. tfe- naiunnl sswtd KyfnesrUoi Acetone ivl kcusahiehsde velopment of the ssubryo was observed ft* the full *ldat w were fouhd m m!y a few simp4w h>n l2 IH1 s7 csibatiou. Inyectmo uf sulns. of pwre I lit and G. and *d tib. i DUCK of l^rodwdng amid cultures mdacsted that the rhirkew rmhry tt ` kfammam povmiamhto cawotratsoa * iMuspnu m ibe wo* scusitivc to these cumpd*. The telatmo of tomesty of the atmoaphere A \ Mnatsakanyaa * \ B. Ait^syan !) samples to mortality at (me of hatebmg, exhitated a h*%c re Lpulemed and ll>g . hrevan*. i w*u, h>`. U H sponse. Eat*, of l*irir prnoot pulscti wrtr sustutr to the ilhd'Kiiw A omew id 11 22 mg shkdupetwe m * wo* the 5 (Sihyi). Addn. of I B. in such uneuoiammaicd nti. pruduevd fhre.s.lw.ti.d cutirn. fd drervasmg the sudhydryi dmcn m Idaiw the expected toxkrty. layection of ext*, from naiauniulid - humuioutn and tacreawng *dtwrin<r<pbwtpfc*i*w actisil) '3 pewut ymiducts resulted m a tuiic response that currelatid well is tbf |jmf utfipwdoau^niif M *Ujt. `Mating to4 with that obtained by mjectum of pure 1 Bt s4as. at same dose is etfowdered a prt^wr mas. J**hn llitst 5r*U levcto, and m must tastonces Uc shim, analysis was confirmed. Sfloct of dichkfobolrao on the olfaciory W|tt* ad buw TW presewev of I Ui, Bt, ami Gi had no apparent effect on the mwlytori. (i, \ , (kervyan i Med. U*t . hfes-m. /. .laud .* #m.n.U$L}.A,.i iL,tnhietty due to I Bi at the level* at which they occurred m the .Vrsi .vNA. Aid. Auh UiTj. !(l f lw*4ktui 7hi v? 30P*rtMihf samples tested. Sepo, of l B, from caotaminatfd f tlireshuld tvnm, fir s dschltwotnitaur d' ehret oa the tlTctiffy Coext*, by thindwycr chromatography, and it* subsequent Chilian analyturs was investigated with 15 patients ao<) *a> iqual to from the plates and hyctMi into the eggs* confirmed that the 0.34 mg./m.1 Effrcl *4 I <>o the wi1 center wa* rusul *m CO toxicity of these rxt*. wa* due primarily Oithesr 1 Bi content. 3 paiimt* The results indicated that in suntr dm ()J1 mg./ H. A. Uppir m.* uf 1 produced harmful effects <tark adapiaistn. A eonen. glouropboritk amd chomkal atudioo op tonw--nfgwisa follow* of 0.34 mg./m.* of I in air so considered harmful, lag tho foodrng of toxk poadnt m*l. E. Annas, A. H. Cumet, "* ^ , M CharmaiMlanaii w4 CO S. E. Mxgwuod, nod k. Jericho (Animal Diseases Res. Inst., Sfloct* of inorganic flnorido* on uwnwlt. J. U, Sultu- Hull). Ctm.J. Comp.Ma. Fd. 3ci. 2KU),2tH*8( 1984HEng). (t'oiv. of Wi*con*in, NUdiwm). J, Air IWuium Cowitwi Att* . The consumption of toxic peanut meal by swine leads to marked 14(11), 4ti|-4. IfOlWiOEni). F` toxicity in cattle can ft* altecatioiis ta their efectrophoretac scrum patient*. Expc*. cor* suit from thr ingrstmi) of forage contaminated by industrial ned out by ehera. assays, moving boundary electrophoresis, A proenses. Cattle are affected when F ` levels in the cumpaet is 1 o aid starch-gel electrophoresis showed i relative decrease in the bone exceed &VJ0 ppm. Marginal toxic edicts are n*tnl tn albumin, or, or. and ^-globulins, while y^bbulm appeared to animals with P~ conrns. in these bones of 4.Ux)-.VjM> ppm. be considerably increased. Rudolph Sciden The eonen, of P " on forage that fan produce these coticns. in Ooitrogoaic activity of ally! iaothiocyaaatq. A wldaaproad the skeleton depends on a no. of factors. Air quality standard* Batural mallard Oil. Pavel Linger and Viktor Stoic (Ccskmlor based on atm. P" levels are not feasible for prolictmg limliek fj J 'tt J i&fii r` -t-+ ,?a ; ... y' * r, * .. ` ' ' . ..* - .' - - ~'4 >-.1 '4 -i >31 r,t::.. im - : T/./rL-T** tMiUwaUwwMti mimdi Lz S'!- &H ti.. m\J 4 - -'-*;'it;5:''4?: r . ^..v-wwrsfey* -v ^v./rr-r^ "j:- ' ~'-Si ; --:- -v----^ " , /.".. 0 "^' *:. ( v . ; ?a '***" *.L ` ;--'-* '".'.-X-.J, ',.'v... <: ^ v.ni&fittftilA fclV *iVi |1 - ^/r J -t *. 4r_^-JV7 .---. ir^^Hx7 -- * * '-** * *-.L-"'" N . ' :--' v--3 - . .--- ^',-Tv^J? - ; -. -i->.^-.-.y,5 ' : -1 - ``*1+'''rT^p'i.af -v' --c >. ;_-, yHse^ - ,;y ''"' ri'-->ss . * . :*'' r of tof< but diwlnUd. UftdlkiiimatlbttMtHi UV7 My tipfaii uiicosis u * pltbol. procty rmlling (nun w.tkt ad. utd Craeuml ukcip of liitck Add. ws. 0* c. T1o64txrtef- Preda, S. Ahrudeau, Liana Ivan**. Zn* Anew. end Clara Vote* hay Unit. Hyg. Cluj. Romania) /fiews (Bucharest) 13/6), 4h- IMMffMMKom). The blood of 76 werkm of a fxiyivinyl chloride) plant w*a investigated. Found were decrease of albumin Urty iDlci* G- Worth, L. Gasthans. 1C. Muysets, And F. and inmate of A- and yflobulin fraction* in serum protein*, de- flfaboff (KfUkmluo Grafsrhaft, Mem, Gee.). ffeitr. .W6aM. No. 61, 1-63U964). Physiol.. palhoi., and i*rtf dote were detd. on 366mJ tnm i|N 20*39 jim in tanpiriiim with 36 badthy wwkm h the ium age fnuy sot (ipmed t mam of the d to m ratio of tenim lipoprotein*, and decream of the serum cholinesterase and pseuducholnf*teru*r activities. Blond catalaae and efum pyruvic and were normal. BTJQ thocnoryhology ot brain eJemnsta of white rats with chlorw- Bariy alimii, bt0mh( within 10 years. wu detected yrene pdimniat T. B. MonnyiR, A. V. Mnatukiuytii, and h 386of the eoal oiotes. Vital capacity of the lung*and forced __ O. Kh. Galstyan. im, Akad. N*k Atm. SSRt Aid. .VaaAt If icapilutory owl. wore significantly lower in the miners, regardless (9), 51-WlVMXRuttl. Results are reported of histol. mvesti* Qf dint tapoaure or the devetopment of sihcosis. Over 50% ol gattonsof the cerebral cortes of white raisetposed to rhlotuprefie thr tnimn with evty nliroaia required a greater reapiratnry vol. (li dunng 6 month*. The chnmtr effect of I in dose* from 0.S6 for l fieri uptake of O than did the 26 contrain. The arterial mg./in.* to 3.116 mg./m.* caused intense dyitmphie changes Hi pOi in miaeve with pnenmoconaiwt was lower than the nv., while the cerebrum- In general, all dystrophic change* io the (wt the aleeahHOrteftal gvadwot of O was higher, both at rest and 6 Ini tu atrophy and wrinkling of mw cell*, swelling, tigraiyut dmiag tfot. These effects were related to time of exposure to and hypochromatosi* of other cells ami Anally to (be acute swell- eon! dnet, attbongh not in correlatiou with the *-#ay findings, ing and varunJiution and destruction of cytoplaam. The last Analyiit of BHiiiamrp argon prewmre curves showed that vrn* changes are more sharply expressed in the elements beneath the tilotnr tronbln ncrurrad in 6.6% of relatively ynuag miners with cortex and medulla obkingata. In I lie circulatory system, hypo* early ilknia bum l(H3 years of dust exposure. Abnormal!- tnnia of vmri walls and proliferathm of the endothelium ukc fin of gaseous dftftamoa also occurred. However, there were no "* (dace. M. Charmsudarian _____ ___ i in the add-faaac metabolism in early i Ctamlaation of ttriao for porphyrin in somo occupstional b aa nwosnri with that in the cmtrolt not eipoaed to dust. peisoaiog*. A. I'etrovaand U, Bakalov. A'kifteaa(SoAal<H4). If nhnnua W. C. Tobie 37-4|(UeVlkRus). Urinary ciaron. for porphyrins wa* earned Mofwmy vapor ha fool oAcna. W. Ketterl and K. Lam- out in subjects with ocnip4tHmal disease* and in hralthy individ paht < Umv. Mumch. Ger.). />eal.jEaAarrwf.^. K0(1S). 1114- i ual*. The remits obtained are compared with thow of Uver- Itg voaiAiRiMltu of dental office* may item from funrlion test* and unnary excretion of urtihilin and urobdinogen. pn storage or from improper tccfcoiqur in prepn. of anulgums. Increased urinary n>pn|>orphynn rkcrettoo is a eery early and Plapn cootaimaatcd with Hg are not completely free of lig vnutivc indicator <>f liver fLsRMge. The investigation mvert 19 a. aitee thorough soup and* watte washing. Measure* sug- form* of pseimni, 3 bring combined. Copropurphynnuria is en Od lar mMsimunac thr routammatiou of dental offices are dis* countered m 13 forms of poomiunf. vis., lt|ronr, henrene. I*b. CO, Henry M. Koehler -- Hg, Co.'S gases. TNT. MeCl. aniline. MtvCO, KCN, and NaOH HnataosogMadeo modlicati-- In chrtmir atpurimoatal potson- + hquid sap. A more thorough investigation wi carried nut taf bytseyt. E. Daturie (L'atv. Naples!. Friss Mid. < Naples) by performing urinalysis in subject* poisoned or subjected to 49tlb 7*7-78(1964Vital)- Tbe poaihelrty was studied of 4etf. the noitous effect of gamfine. Copei'jmrphprinuria i* a sens*- aariy w hirst chaagea ta cwagulslnm and aa metrued teadeocy five and more frequently nHwntefnl miieatw in mtvpiiNituJ in haswrisfi, m. of tbe ihemabophsltc type, even wbeu test* pmmmtift. even in the ptrsence of extremely miM liver damage. ysBie acg. hr subjects npuad tu tetryl. The studies were d L'nnary rsiprapoephynn fitmrni is very frequent tn genuine Uierifd w e 1) rabhsu; 3 were kept as runtrots aad the others pummi; it may even appeal in apparently healthy individual*, wvt green U.I3S g. tctnrt /kg. body wt. oealfy foe 6 months, who are in cnntinoai fui with ganilure fumes. Pom .Her. Pmrmg tbe rstur period th* Mtowing lew* were made: thrum- BmJf*. Vi. f.tf.. Mfd /*!). ('Wf, 64), WdWili TCFR katmignuM, pnbsnbh time i\}inck). pmthrombuwnua. Tbe marimuiu aOawable cancantrstiao of dibutyl ybtbalst*. auihneiaa* naieiaiae. and a direct blood pUtelef cuuni _ Mineho hpuwivskt. A'kifirao ijvifisi 7i|). ,1m 44( Ihdtji Bulf). fPalumbo and Huo). Blond was nfWitid ia a ulwmuted tube. The phvs. and ch^m. qualities of di-Hu phthalate tl. are pnmtcd Altec 6 mnatb* tbe Mlowiag ebaages {im %) had occurred; *gt. the l,'iw paiarnetm are e*talili->hed. iisi it* acute and psntbsuadaa tw, fviaa MJ to fR.l; prsthrsahstau, from chrome rffmi oi LW different kind* d test uirtiuJi are stmhed. HA to ?5A; wtilmsmu. tmsa U6.9 tn W.T; conesrtioemta. The xuthr del. i) *o*| mg 1 of ir ar the max. alk.wablf imm, Mu Hi pUtrMr/ni. aa,, Itsn k>*A3>l<v4,AUMi). of tech..I. heated t over 140*. on the bow* of r*iun. of cnodi- ~ saw of tie fartmsdid M change apuksMly, >lie / |ord reitevrs, latent jteri-id, oerght rorff. of liver aod krdoeys. oafRUtM partnre m dehnitdy aitered by total body ot- motor activity, and Utigue. The tuxinty of t poaumng. The puoobdrty id intravital hemofy* detwnds n its route* of penetration into the organism. The Tle bum definite entity vai the deerraw m vapors of I, heated tu over 14<i#. are mmt luitr, rauung like- Febi .Ssuiuk-e* wise pulmonary edema 11* lev* tour in peroral admtmstralmn; hygienic aama for soma caprolactam tateruMdi'_it ha* no tkm reuff)>tfveeffect. It pwm a very ctrtmgeumu- am to the aimsapbaea. A. A. Hutounku iCentral lost. Ad- lative effect whrn inhaled a ap|4icd by mouth. The rumula- vnuced Med. Training. Mnscwwh Oijiewa i .'wiaii. 19 li. h 14 imi ncff r < I, rtpljiRol h> the tleveh-pment nf high t vn(IMAhltoas). The |-4ktmog Momv id cyrhihexamJ * I *nJ uitnty Frum .t>i|r AWfu* .Vi. In.. Mid. /**. <Ul. 7(2). rjrhdtCMumw ill ta mg ra m rnp i---~nrtini threshold ASdr No. TCFR far taectswo by odor. 0.24.0.2!; bvtufluenceouda/kaiiipU(K*n Csrbmuc aahydrase in occupational load poisoning A. toey*.--,0-11. detected by effect on electrneuetml cxmuw**ntd t lia(<4ska. A*jw4oi Jr. .Vsmke.vti/'d. fori. fMraoa T'mifs fcsponses, 9.14, 0.11, tseummended mflrtip*wr max.. O.td, Za^ajwruat/a 10, 66 mtou* Rum). Kxamns. and lab. Qj04, Rat* silt wpsol to atta*. cnntg. OuUt mg. 1 and O b4. inveMigaistut were carried out im a vnn of HI workevv fram a g, II. nu./n. n foe A| day* with awvjfwerved changes in ttiu^ fb wivks. Besides the characteristic Pb-pwmmng mde*es, rulai rtonuaty flwiixniniw hrlmfy, sulfhydryl bl-wd raocn*.. the changes in eariMmwanhvdraae activity weveahodetd. SiimulascncW and ntuint*. in brain nod kulney. 1 and II oere drtd. tanemivly with deteroprstmn nf the peneral phys. mtuhimn. a* uuog the atomptnin* *t 510 and Utf m*. reap. -- fir a* !*b imtuicntMtn is enneeinetl. enrbemic anhydraae was J"hn Huwe Srntt aSrtSL' tolnuodn dt dto gynvbstic Awcihat polyuaude. N. A. Rakbrnamna <1. M. Srslwnuv lit Xlwl b* depressed. )*b pmmning bnngs almut a deprvmian (already pnooi n n/uld tlirrxiyme m nw. Frwu^fgr. ffa/fcr,,ih, /,!.. \l*d /'kef. C%li 0)41,32(1963). TCFR |m.. Mimno 1. (/iftruo i .Soon 2tii2), J* 3UH*4 Rut*Carbon diosido transport in tbo blood f patfaoto with sUicosto Thu L.l). ealues uf mdyacryUtiude (I) foe mne and rahhits are and ulKOCubtfxuloaia. Khr. Twilov, .Yoockot T*. ,York- I2AS0 aad IIA3) mg./kg., re>p. I"hew may be due tu the ff mri.W. /iu. dbiu 7 rUa Prof. ZnMjamntm 10. 77-A6< 1VH3) momurwr present, Unm ot 1.5 mg./kg caused change* in the t Ru*v- The trampnrt nf CO| tn the Ithwi t* vtudted in 370 pa- ruuditunwdreffesesof rm w9month*, Ihemummendedinax. iunts afleeietl with hIkdiu tmth varying degree of mamfcsia- eoncu. of I in drmkmt water i* i mg./I. John Howe Srntt turn* n( path<4.) an*l siltciduhrrcuhwt*. The partial CO teimon ChMi hltwia of a oarist df refractory matariaia. II. A. m alvw4ar air is relatively li*w. but it is higher than tn arterial StatmeTsoo, M. F. Lrvnyasre, L* li. Babushkina, and L. N._blrmd. The CO phys, divvilvetl in the blond is alxu deereasod. Bl'fuchnykb (Med. In*.. Sverdlovsk). f#ifieua i .faasi. lh 12), The total and phyv dnu>4vrd amt. of CO in the venous bfaml is SD'HIOMKRtutl, D*wts of vanuus refractories were tntrm within normal physiol. The veunus-arteria) difference is diced utrttndmUy into rats and the effects studied during 9 inuguifirant. The pngrrmr detrnoratton of the rilicate-tn- months histol. and by detn. of hydrmypruime and lipid <mcn*. dured process results ui a mmiiuraiive increase of the partial COi The following gruupa were prugrr*'vefv less hannful: quart rife tension at weft as of it* phys. dissolved part to the arterial and and dinai; chamotte, day < l2Ve live SiO,), and Cnrsterite; mag- a *til more in the veniai* blood, with ronvapuiMUng decrease of the Mdtr; andchrofnomagnfwte. The recommended max. lur thee muo^irteml difference A state uf hypocapnia also < groups arc 1, 3, 6, and 10 mg./cu. oi. air, resp. versed in patient* with vilicntuhrrrulosif. The sepn. of COi John Itowe Scntt from the Idfnd of pa*ieiiis with cytutnxie hypoxemia --cm* to be Blocbsmkal chiain in ssrkirt occupied is vinyl chloride the mmt difficult. wurrra* in tlimr with anemic hypoiemia the gythoais and potjBitnialien. falvia Gabor, Mina Radu, N. least. The and-)ciw balance in the btaud of patient* with aUi- % ** 'f. >, --i-v5i Vir/V'l fe4 -t. -.-`S f;1; !-L- *' j.' .Tut jt . ^ "* -y * .* (, j -7 ' ' S';- r.: - - v kY;-.y, m md VP ebaaeese^^mca fa and ^weee 1- P. Botrrt. Mat W. Wdfaam, ai Gan C. a. t- DaVafal Mm* (U-S. Dtp*. a *fr.. CTiaairbw, WMk.L Pew. rifpiaaa te.iiaa.M.a.il'itaaMXKM)- SmmtoPMiipt > twmm it**- ^ u a. loll. P*v- KaasnMB.avMlUMU^tewaliapiwiU Cd Mi 4479* to 17 aw ran biota) MibdlT ndxa ehoot pwtt aad fahp. tamG tha H. fa blsnm the lollowwg P*nc- Redacad _ __ ^LTwa (Oil~P--tt--wpaM^itamlwwupMJM-lOIKl-- h M pa> Uu pa Idem <M. Other effaces mi a evda. to (ran an, IRiU ^MSTaStuIli M when peraltmnaidi larger inra, May fa bin-lay. itamr (nit Krai (GeMea DaKkn).ia4litnaciH mammy d irwtAgnia PMAm.wftww<i<Miw<WCA. Uirapv Lawrence P. U9fa l if fUrTrilipfa irtiaamlt add (B-lffaa) an appfa nality. Max W. William, L. P. Batjm, and Geetyc C. Mania c (VS. Dept, fa Agr.. Wenatchee, Waah.). Prm. Ami. Smt. Hmet. Sci. . I7-19(lWMXBoi). Spear* at 1000 to 0000 ppa. <MX plied 3 lime* ehartly fata full bloom Largely prevented eh* de- (Bahea-Bfayfa' Celt.. Cfaj. Rntnaam). eelapaeet el aeald aa Red Delirious apple* fa Mtn|t aad Slg* 10(11. I!0 <7tl906XOr). Semi eyes.--aihrastly encoded the ibeU life alts removal from storage. 11 (1) (fdyMfaim (tycol) me desaae- There were no significant diSexsieea fa tot. solids, pH, aad total ad. hpa, fanadhma. beat, am, wheat, titratable acidity. Thera wu leu water-eol. pectfa aad slightly 1--* T -*0-*. ** 1 -li---------* r*-f---------------- -*-1- A more total pactm in the (nut from treated tree* alter storage. faran cm, fa I u-am^e --melhi fa omfaard aad ndlih, <*' Lawrence p. Miller Em natty mimafatod amSfaZfam <3 aw brat. When fa* Ktbyiaaa actfaa aad tha ripening fa halt*. Stanley P. Bun Mbkm oeemrad. aaeyfaa* aad ----activities were reduced; c aad Ellen A. Bart (Uni*. fa Miami, School fa Mod.. Miami, wbca mlmafathm occurred. them tniymce were tocmamd. I Fla.). Stiaum 141(3674), UMHXIBOSXEny). Moatly a re ad 0.01-1.0% prevented diviafaa aad yrowth fa tha altae cell*, i view fa repeated evidence that Celle U a fniit^ipauac hormone. J. J, Willaman { tmetie etudie* fa the author are dacoHed which indicate that ' 'c u.- . . *>t * Uact fa thhadh add aa eInMhe cad yeetmpicalty far CO, competitively inhibit* the that *wcllfa| effect fa CrH, aa daoad raworv al Atma cofaepcilan. w. B. Norris, Jr., --d' etiolated pea rtem tiesue, aad that the effect fa O, can be a- nratrira Tinitgawn (8. W. Ten* State CoU., Sea Marcos).: pfafacd by povtulating that it moM be present at the receptor Pkytimi. Piialir m 1K2), 403-0(19eSXBa(). Gibfaerallk add! *ite lor the C,H*. Their etudie* on the C.Hi4ike activity fa (t) at 0.1 ppm. itkaulatad --**-- dongntioo. Mixta, fa I and | various compde- indicate CcHi bmda at a ipetallir receptor site fa -'A liidaltatclk odd ahowed ao eyueigistie actioo aa deqeliai. 1 i time*. Joha M. Lawrence At 1j0 Mitt, herttad tht uL < --**^"^11* iw<iipv( miPd. a thwidwit Mriaai tl Maid* k --*ii pMPMtnlkiii. tm molting siter luimUtTM far WO max., but did oot cab* a d Konihikn Sbw> od Toahio Y*nki (Udit, Tokyo). Sci. derarVahlv effect on rlcngslmn fa the intact oolenptile tip. Pmpmrs CmIt. Cm. Edme., Unit. Tmkym 13. 203-ll(1963XEay). J. J. WUlamsa la the pee aat* fa 1 my. fa indoleacetic add (I)/l.. 0.1 my. fa Matt* fa aalwrtraiod phaanla an bad Iwmallua aad yiuwtb hinnin (II; 6^nrfnrylanifaoporme)/l. promotes set. moeaae fa fa tabacea ttmaa catena. T. T. iee and P. Sbney (Uair. fa tha callaa and that fa the original time fa hypoeocyt quantities Wfawmda. Madiaan). Pkynml. Pltimlmmm 11(2), 380-402__ fa Hddmlius mmumml; however, growth i> hindered by 0.01 m(. (ISOSXEhy). The times ism grown on nutrient modem fall/L la thepraaeefa 0.01-10 my. I/I. 0.1 andlmy.il/Lfa> tepimmued with 4X1 mil Xhietin aad 1.1-2.S mil fadfanectie crcaaa the wt. el carrot root crowns; 031 my. 0/1. loaiiwi. add. Compda. tewed wen bans rinasaiic add, piemyipyravie the growth. II eearaa. fa >0.1 mg./l. faoeaie the Wt. aad tha arid. L (lhrayialaninr, ddtydrrayphehylpynieie add, ueyteaiaa. growth fa tha cotyledaa oowei fa H. aaaaar; the growth is fa. 8-. *- aad I ainanhydnuydnaeinie aoda. caffcm add. l-3.4- hihend by abewt 10 my. fa H/1. The tnaaani fa hypomeyl dlbyibraypbeayladafae. lernlie aad banaeie adda. 2-. 3-. aad 4- a qnaaaaruoaa is inhibitrrt by 1 and 10 my. D/1. (therrvaram fa ,, -J! - -.`LH-*t 5^ 3: /Jv?; I 15471 Oumicol Abttnuu 15472 VW. 03. 1005 TW pees tarn Wat owl Art stable for about 10 dtp tfsatn* _____to tight* L* Dnpsii DDT ad DDK to (ho body ftt of mpli h Israel. hi. Was* etWty. Adds. of the above ivmtimi to y-BHC itmthd Uk permeability into UrvaJ bodies. The synergistic mtirity of glycerol dvnvt. on tome inwcticMict i|aiM the adult house* mom. Dan Wimmab, and L. Zotitnuayer (Hebrew Utiv., fly m D. m*ian3g9H*r mi rund. by the contitt method* ferroakro). An*. mvw. Hmitk 11(3), 37WKiDMXEnf). The foUuwtng compds. were synergistic in tkcmmof order; Thy av* taa. of DDT in suhniiinaraii (at of the p I, I wHnaoochJorohydnn, 1 w.T-dichWohydrio (do Activity). gwBiljopwlirtnt of lend b 6.6 0*0 ppm* ood of DDR, Ethylene gtvcol end propyknc glycol were also tync/iutic, M DOT equvv.t 10*7 * 12 ppm. Cooau* are comparable These fads were ascribed to the inervos* is volatilisation due to with tbeo* loond in the papuistiuo of the United State* in lb5.. the *bov. syn__e_r_g_is_t_s. _E_s_t_e_ra_s_e in__h_i_b_it_ion by o__r_ta_o__o_photphAtes No agnificunt differences arete found umbi samples from Jews) or carbamate* u studied by thin4aytr rltctnpiuniii. Kster- d fiMpaA or Asiatic ethnic groups* between samples obtained! *jc* susceptible to orgaoophosphsirs were different from those Iran smdat or ilium cates* or between age or sea groups. r susceptible to carbamate insecticides. A combined ate of Raymond Zehnpfennig | orfanophoepbates and carbamates did sot promote insectiddai Conipartftva ksoadgadotts f pbosphooate prsparsooas.j actioo oo the strains of housefly. Kent? Toni H* W, Rabn (Humboldt Univ.* Berlin), -4rch. Expu. Vtitttn+V*** Effect* of soma iaaoedddas on inioetatlons of the sbort-oosod oennMf. 17, 28l-94(lM3XGr)* The pcstkidal Dclicia spray cattU tooao. J. A. Shcmanchuk, W. O. Hanfc, and C. O. M. concentrate ptepd. by Thie and Wucrker (Gcr. (Bast) 21,737) Thompson (Canada Agr. Krs. Stt*, Alberta). Coo. /. Animal from dimethyl phosphite, chloral, and (ormaioide cootaios as its 5c*. 43(1), 56-64<1963XEng). Com. available pesticides were active iafKdfcnt 0,0-dimethyl I-bydrory-2,2,2-tfkhloroethyl- tested fur the control of the short-nosed cattle louse, //aware pbosphonate, m. 78*, as deed* by purer chromatography sad pin** euryrUmtu, A single treatment with Qf 'c diddrin or comparison of their acetates, vinyl derive*, 2,4-dmitropheayl- malathkm at a rate of 2 pi, per head at a pressure of 400 pd. hydraaoma, and toiioty to rati. Martin Jacobson was effective. Chlordane. lindane, and tuxsphene applied at the Dotanainadon at the effect of the phssphoasts trichkephon,--same rate were effective with 2 treatments at lfl^Dy interval*. In ko commercial properalion Bohniin, an the motsbohem and DDT was the least effective under these conditions. No rig* amatory insrlisiiism of cows firms mtrnvonoun and iatra- oificant difference m effect on louse populations was observed BMcnlar bjsctiflU, with tho aid f mdioaeffsa phosphorus, between sprays of suspensions prvpd. from writable powder* M, Kuebamt (Kart Man Univ,, Leiprif, Or.). W. Dedck, aad and emulsions prvpd. from emulsifUble concentrates uf irndsoc, H* Srivii*. An*. *pd. I'dwnrwif. 17, 403-17(1063) _ Co*JUJ. KorUn* sad maUtbkio. Three irvsimnu of Trefcac (Ctf), Bubolia (1), a com. peeps, coatg* 500 g. 0,0-dimetbyl * administmd orally at rates of 100 mg./kg* and 75 mg./kg. at l*hydrvy3^^-tridsloructhy)pbcapbonatc (trichlorphoa), 5 g. intervals of 11 aad 0 days were effective again** louse mfesta- pyridiaa&wkiorime methuidide (PAM), aad 1*5 g. atropine tana. Trokae at 10 mg./kg./day and & mg./kg./day fed to lfrt* in 1 U at higher aka., was labeled with P aad injected cows lor 22 dayi reduced the lour pmilatie*s but did out pro- into rows. Only traces of radioactivity wm towd in the fece*. vide complete control* A liaise population hides. rrniMsttag at Blood dnm* shooed that >'; of I was metabolised to noo*_tb* total no. of bet at 52 mm, each of 2 cm.1 in aim. on the toast imdacti wrihm 1 hr. after intravenous injection, but l aabnaTs body is deaenbed. RCCR was detected in the blood a* lung as G bn. after intramuscular tbs affect of paraihiea oa rat liror and bifstr mbsiyhMW tajcctio*. 1 was wmtri in the sulk for as long as IQ bn. after save, hbctla I. Head and W. r, McKinley iUrpt. Natl Ilealib alar iajcctiou, wheross injected DOVP amid oat be I Welfare, Ottawa), toe. J, Ah 10*. KOnW iwUi _____M__a_i_nl_y__n_o_n,t_o_s_i_c_i_rw__t_a_b_n_h_t_e_s_o__f _I_w__e_r_v_de__te_c_t_e_d__i_n__th_e_ (Bag). Rats uf different im were frd a dart c*mtg. lu pps* Iajcctiou of i lowceud the C aad Hg concent aad eryth* d pamthiou with or without viUrua A wiakemutpo lor unm fucyta aad lymphocyte oouau of the blood serum aad in* pmuds of time, ud ihc vffvt* u> bm sod ktdary eubitd* * fiiail the gmaalocyte count, luirsiimmi aad mtrsmusculsr ewerasrv wvrv wwwired. Mrlvd alubiiA of carbnvylrvtev* iajectsim of JO and 25 ng. 1/kg^ ritp , evoked an hwtopaihol. asm was obnerwd ihstiy alter the |uritAa dwt ** aim gftHWgea ia the liver. Maltm jacubma daccd. The drysro of lohitutvw w* not sirred apfwviafay by Saacapdhility d krtadha wwwbfi, Umaadrika sscubs, .raBiasri (evdmg of tiw dwt euatg. parec.nMu. ivutf kmaie aad Ltasrinba wiikyi is sousral acncuUaral chamirsk. rats liowcd wear rwrr of aver arhnjlnUfin to row* Tsdshihu Imp aad koodo < lhacu Agr. Qvo, Inst., uawrd of the parsth*^ <ki. After removal *4 iuaa Sbaius, Japan). Baiym-Katakm 27(4), 97-M1062XJapan). A from the Iwt. the irevls o# L*evra/tooyanterwse aiw i^i* thsuiiitslilT M iil (Qfifhna ilisnua, DfTT limitat mitrin. fed pratb*u inctvawd sppevcwMy. kvVH dkldnu, fwaai. pymhnas, Kl (prauchkaopheagt) Na Sami geaeoc aspects of resistaaie to eudna a tha hod wowed, ak, and BPN U>Et Qffampimyl pheyipha*phpaothioate) e hUboaus gruadii. r.wski khe*. )r. < itu* A k M wasdcid. by iwmtfwne. ff. sravrSy* was the owM suscvptihk l ose., CoDrg* Sou* . ( ow. ifueex'w* ' Aaa Arhfw. Meh./. to ihmt all cbmmh aad L wdkys waa the knst temptibk. Ckw Ai. S&-7S75, ]4o pp., Pumoot .(Sai^. isi . 5 1/4) FCP-Xa salt waa the bvU cffmttvv for the 3 sqaaiw oligo. (t-og/* Marta* aad roteaoar aad p)ifthw for />, awdn. bYjS Heasvfly u/tplMtasi with ssnioUr idawa to S/aapKic srttsa of Stm vuh p chlirnphoayf p-ddoro- phoaphats lUtfisc* mochaniaais. V..,-lae* haaaHBoauhouuto. Maaayuks kaao <T*k*d* Cbrtn- 1.,--grr* I'biv.. N#-o hrunswwk. S.J i mm > Ann Kpste, Japaa)* ffMy. w-Aaroh* M3), G7-7jlHM5>,Enr)L The Arbor, Miu.i, t'Vdrv ,Vo. PS-TlPS. IJv pp., Oiuowvi ISae. __ . jd ^htorophaanyl p-dihiaibriiirawwifonar iCPCBS) Jb I). 440 15* Eng;. 5, NIC for fm (Imapfathyl A-urtbyiariauu) aad its mode / Fffsrt rf rnifrirfsit tasarti irits na fnfiiaotls scyi^riiMisa aecioa wma studied wwh 2*day*ld mlult maks 4 CaUhs*4vukni Praia** imron. U o. J 4 and l j finasi by the dry-dim coauct methud. aad wnb 3 t May- f Agr. Res. lu*i.. New islbu. /*m 27 |>, r,M old aduk tcaaki of Jfosra fmnbi, young adult mile* of * <lUfl5XKag). Tafeiog L.C.* Vthsl owa.i %Mwe of c^r- AUMh gw--sir*, aad 3rd- to 4th lastsr larvae of Prodrum baryl ns unity, uat *A 14 lawctniur^ inbtl sgnawt the adults Idara by the topical npaiieatwn method. CI*CBS potentiated of C. upmaniui, uciatas, r-aa*. ^Mtouido, nad Insrniridal acttvuies uf wane earbamstc iroiardn web u dkbkowwrfr. rrts..4Ut 7 4.7. 1.4. 4d 1.1 imn * tuuc Stria, l rhlorwJ^iylyl ,Y**nrtbykartmcnntr. and vbHC sscavMryl. CtfUshtasbua, tnrtilepwa, pynchrou. sgamn C. dtaraiu. The lyisipm uf Cl`CBS fur Srnn was _ adUa, aad muwm wvrv. r*p*, ahrot u^4, Q4D. U.'d. QJ)13, akoobmwed agaiasc if. fmanrs, &. prunes, aad Z1, ka. sad Q.(*r lam as tut* as tsitni)^ As high as 1* oats, of The most combmatMie uf Scvtn nod CPCBS was bcumodau. rhlurobriuilnte, bvptnrhlur. and thsnite gave only 1:4 art. ratio. The actioo between CPCBS aad piperonyl 3h4l* 27.*. 2U.5, and 10-V*, muruiity. mp. C\ butoiide was coonriifnt to be a tiaulir joint actsuo w&ea bus was more rrioUnt than .lyiu rrmewi to hepuelilur* enrbarri, synergists were used sunaduneuudy with Snit. It wa cun* nod memo^hoa, .4. gei>>/*i to hrytarnkw, cnd**uil(nn, mevizt* eluded that CPCBS aod ptperuayl butomide du nut affect the g pb<*s, enrbaryi, sad fhurstr. and eertmami lu thaaite, absorption aad prartraiKMi of Scrio. 01*065 did w* sf* heptaehlor, rotvnooe, tMiauiin, caiboptomoihtQa, pyretlinns, feet the naikbolincstcram activity of Stein in retro* Cl'CKS pbuphnm>.*j>o, phintr, and (vUr>l- ll was less resodaot to raised the isbehrintitnut activity in the body uf C*. ckisroni, mevinpixo sad dichl<irvus. Anniog lW uwtucdci, rottnoae which was aseribod to the inhibition of the Srvia*fetosdyinf and caduaulfan have mown a vrry high ulety margin (or C, .tuyav, KcstuTofli srptempnai Alio adults, being at the tame tune effective msecti* Genetic aad biochemical stadias m joint action of lasocti-"*ode* against /), canAjmt. Mays Sanyal cidee, Tsutomu Kasai (C'mr. Osaka, Japan). BMp**Kata** Control of Prodsms titnra on cotton in the north of Western 30(3), 73-01(lV65X&hf)* Relations between the chem. stnic* AostrsiU. P. N. Forte and D. G. Shedley. /. .-tgr., IF. .4as* turn and synergistic activity of gjycerol (1) derive* toward fraAa 6, 4*W(lQQ5XPt'g)* trials in early spring shewed y-BHC was studied against the larvae of the housefly by the American Cyanaiotd 44UtX (025-1 lb. active ingredtent/acre) bun--iiriT method. The fuUoifing compda. were synergistic ^ and Uidnn (15 os.) to be mure ufertive than Dipterex (2-2.5 in decreasing order: 1 o.r-dibroautbydnp. 1 ,y-4ichlorohydnn lb.) in eonttoduig P. tear* (bull weevil) on cotton crops, Hayrr I uimonutftlnrohydrin, I (no nctivtty), Bthykae chlorpbydrin aad chkcals west also syoergistic, but not ethylene glycul. The succinic dehydrogenase activity uf the housefly aad Drtnopkiim mafsnsgMfsr was tnhtUtod by these fhmirsli frith synergistic SUffQ, Thioiiaa, aad heptachlur (all 2 lb.), and Phosdnn (U) os.) wm ineffective. G. J. Wylie Response of Redcttlitermen flsripes to fractions from hingna* infoctod wood sad synthetic chsmkala. T. Watanabe sad J, " -t_-V- *v4 r ... . ." r-V- v4'.'. t : r 1:^0. -, p .T.i / ' *-i \ - r'v' r ; 1, 1 - ' '. v. \ :0r | . V:: - , : - r- " J ' ,a- r ' _ .1 : " i , **-* r-j - : - ` -f* - ' . y* r \ /v* . *=) : .i 1 C' ' i'.r* ?py?* S -;... -' -- - .--_ - ..:-;-,V--" '""-* &-'-%Z2m ~:.t- t'>--?^3 * V"; V'^ "~ r' -."- -- L" `'V- --" -i1 .;-' --r4> ,_'-t. e> vi.j,;'-^ *- - ` f*; '.VJ/PS , :i-sm :^m 16211 Chemical A bstracts 16212 VoL 63, 1966 wt. Ruin nckuiri, the new ntatuee 1* believed to be the (OHXPOili. After activation to Ca,NXPO.)e life of rataly cn teoaer of 1. A- Budiiu during dracribed dehydrogenation procctt i* compared with Alkali DMtal MdUk^dlttiecaihuutet. Sti, Akcntrom CarfPCWCadOHXPO*fc (A/B) when this value ia >2. butn* and Aadcn Uhlin (Univ. Uppeala, Sw*3.). Arkm Ktmi 24(34), diene produced/kg. catalyst i* >500. For example* the tabu* aB-MI65XEa(); d. C4 01, 7924e. The foUowiof data an latcd results were obtained. The caialyn is Pruned to total reported (metal to Bu,NCSdd, m.p,, no. of uaociated oulccvlo is CHC1> eoln.. detd. ebullioecopicaUy): K. 134.6-0.5*, 0; Kb. 148-50*. S; Ca, 158-0*. 4. The distribution coefficient (/) of lUNCSiN'a (I) between CHCle-HiO if wnunariicd u followt (K fail./): Me. 0.9 X 10Et,28 X W; Ft, 270 X 10 ': wd Bu.,7B0 X 10-*. Harry L. Yale ,M.i Vmiikblortd (Vinyl Chloride). 1TL ft** 1 - tUftS --137TO. _ * ~Smith, Peter A. S.: The Organic Chemistry of Open-Chain _ [C^nO* U KB fti 33 66-66 66 46 Sft M M 67 activation in closed reactor* at 300-400** lubricant with 0, and steaminf to 565-580*, MlilTH kf-/k|. U4U St.S3 IM.M iron !M $3 909.0$ After burning the sercral routes are Kitncm Compounds, Vole L New York: Beniamin, 1965. described to btinf the temp, to operating condition*. For ex- 418 ppa b atopic, temp, was kept at 566* for 8 hr*., increased by 2*8*/8 hn. to 593*, 2.8*/12 hit. to 610*. and 2-8*/24 hrs. to compleU Pttriflod bydrocarboos. Esso Research and Engineering Co. Hath. Anpl. 290,921 (CL C 07c). June 25. 1965 Appl. March 29, 1963; 17 pp. To obtain ttarting material for isomerization and alkylation, a mist, of hydrocarbon* should be purified v from nlkenes, aromatic hydrocarbons, and Scontg. compel*. Tbtfdou, at first this mist, is heated to 933-176.7* and the Taper is brought to an absorption zone contg. a Linde 13\ or 10X "bateees Sot./vol,/ Or, 1&5 0 1SB V 160 to 1ST A its a 146.1 16 1 16.B IB Q 18 1 ISO 16.0 tewp- Ml* 646* M* 642* 646* 647* ito<*atrail >a twa ir vot./vid., Sr, 762 H> 7 766 IJ3 B ih 118.4 ID U7.4 87ft 14V a *> 140 7 m. Tna Uvkty mo*% U7 XB 6 3f 7 6ft ft 6ft 6ft.4 07.4 07 4 07 8 94 0 06 & V7.0 molecular sieve* So only most of the alkcuet remained, which production. The proems consists in alternative dehydrogenation are removed by coodcnring the vapor and bringing the liquid to ^ ncum-dtiuted a-buiem* and steam-air regeneration of catalyst, another Linde 10X or 13X molecular sieve at 21.1-45-0*. $ Typical condition* are given ia the 2nd table. N. Rusao by h. Immmimti* a .-beiTM. 1, A. BdShov nd B. A. Timofeev*. U.S.S-R. 172410 (Cl. C 07<), June !f#. 1905. Appl. M*y 18. 1984. Iwfaeiua m prepd. by the iwmmutton of ~UH,, oo AICU nd to inrwo tb yivld, 0.5- f S'/^C ito) luN ts ISm aL?My 10 M63- `'W?1 ,, Ci 1 190 440 f 1 370 MS aLJ3,. to ' i 1004M Im.iTM to tbc AICU. Ffom Byd. luirtt. T**nykk Z**k*r 10 1J). ta ttac f,, ||I|UC The nt^yvt n <opod of 5-50`T, Tnvo H.vnn C. 11,1 <h, Rvoii Cu. l-SO^T Cf. *nd W-l-SO^p ttlttuls of th. BloiO (TOUp 1 Mid 11 Toyo R>on Co.. Ltd. (by Ky j ,,{ the periodiv uble in foim of their oid, not reducible by 11 up ^IMJ22Sii??7iLS5]ifS?t i !' * * 11 ,0UIul no *bt 0.01-20% of oo* Of DOR metal, Appl. March U. 1W6.. - pp. Dimemation of propylene u> alt j 0(themup VIH and (or) A, and (or) Zn addni. to or mstciu! of CTl,* Cr yaveu eve,, better cat.Uy.t, The acctyleoe. -ere hydro- with ether was dcscretwd. Thus* a roixt- or cc. itcpt^ific, . g .__, 1.. _ r _* _ .^^ BtfMI nt , K, 2.M *. mmol*, and 043 mole propylent ia heated in KM cc. *n f J! " aaoouf dto4Mc-mlabvecetnhayitrlpe1c5.n0t*-lf-umre207h8r,s4. -tmoegtihvyelp0e.1iu2*2m-onlHeeihroe1sxGeh, ni elK*hcacotamieopnkoeaseAd.'__w(d0autcHeier)odif.gclHoX**nisCtw,aOiianthnei.odduarnNteddreu5CdcreuaidCcCtOiaouvtn, 2wotefr)et*hbebNyrd'oiHi.uoag-lenhfdtinToshJn..eftloCcTaiphtCuauamlsy.,iscCteAt,uhCfmuilOseistdp.tCr,obuoy-f lteuMfuatieo of the C* oleflnk hydrocarbons. P. K. Tulupov and N. G. I'oiyaiulii. U.S.S.R. 172^08 (CL C 07c). June 20. 1965. Appl. March 13, 1963. The Ca oletime hydrocarbons are 95.7 multrrc 1.3-lmt*diene, (>.162 mole-% vinyl-, Kt>, Me- scetylviie, and I vol.-Vc 11 was transferred over (4UU L per 1. catalyst ptr hr.). Lraviny the reaction oven the uiixt- contained isomerisrd by beaung them on Miifo cation eschange resins. To increase the selectivity of the process and to inhibit the pU>in- criiation of the olefins, the resin is first hydrated to the limiting swelling and the process is carried out at 15t)*. From MynL /sv5rcf. i rmrtvU Zulu 1905(13) 17. MHCL 95.5 mn.'r-'T 1.3-butsdicne. Acrtyleses could not be indicated any mire (<0.iunrf). Several examples, varying the compti. of the cahdyst and the rate* of the gas phase components are given iu detail- Marianne Pauling Hydroganatian of 1-butane oo an irradiated molecular sieve. James M. Caffrey, 260-683.9). Oct. 5. 1J9r6.5(. tAopTpel*xOaccotw. I2n>5cti.i)i*c.i'*h|C.a.sSL.iS5d,2e101a.043A7T\eCx1. Butyl chloride. Orgunisatioti of the State Committee for the Chemical Industry under the State Planning Committee of the ..Council of Minister* of the It.S.S.R. iby E. C. Bondaienko, ** M. Kosinskaya, 1. L. Dogatyrev, and S. I. Cherepanov), posed to H foe 15 min. to 2 hrs. aMirpuei.VMsiaeJn"aas tL-sifuKliuetmiiidoVip, hiseerixc* ?nf^*Sc^B,,uCl^uureod^fr^mthr.reta.c..t.^* nooof hiSuotth w?*.t*h. Ani t^he pressure, then r^nndisted with 0.1 X HP rs. Contacting H and f^J^IODJ>l ?"?" w*tl1 'Vr)*lh* 04 to 50 cc. pwiai bgtnv per ,. of tin* adwwbent At <1* 100* pfrovnc* of ZnCb *t elevated trnip. To mciuse the yield mid molu in by2^TMTtioo of the butene. L. R. Cmwvll , ennw .wmmuon pmcern tbe prom, i, cmrwd out m mi .q. Olebs dlroerv kfonmnto Co. (by J.m M. Sehuck and > f,ZoC1- trom ^ 1 ^emn.ykk ZmU-lWd Robert C. Sehulti). Fr. 1.40J.273 (U. C 07t>, June 18, 190.4; . . - ,,___ , - U-S. Appl. July 12. 1903: 53 pp. Active C ia treated with XU, ,, CWormat^nof alkyuoU- Chemuch* Werke Huel* A.-G. and impreptated wnii a Co alt of an alkanoicacidor anO-oont,, Fr. 1,402,390 (Cl. C Oa), June 11, 1905; Ger. Appl. Au*. 3, mineral acid, th* rrodueu are activated at 200-300* under an in- 1W3: 10 pp. DiehlotoJktnoli are prepd. by cblormatuHi of ertfaa to five Co/C. C,.iilefimaie polymeriied in the prea-_lkytuib in the practice of I1U at <-35 . Tbua, 224 part* eacc of the prepared Co/C to pve liquid dimer* which can be tued CHjCCH^JH, hb. i1i1j4_-1ia5*, ,s.a,tdd. at ---4a5* and 900 mm. with 220 m the ptepDa of biodegradable detergents; catalysts activated at ports HCl and treated at the same temp, and pressure with 450-550* can be used to dimerine C*.w allccnn ctmtg. an internal 284 parts Cl yielded 245 ports Clf!C:CC!ClliOK. b* 80-?*, double bund. Tbc olefins are pasted over the CWC at 0.1-2 and 132 parts CHCl,CCl,CiliOH,b, 75-95*. SimUarly, CH.OH- g./g. eaulyat/hr. at 10^50* and 3.5-21 kg./cm.' Thus, 300 g, CCLCClCHtOH, b* 13tM8*, and CHiOHCCIiCC1*C11iOH, b, BFL activated C is treated with 306 ml. turned. NHi, dried 2 hr*, g 175-85*. ore prepd. Barit Farah at 120*, treated with a sain* of 2M> g. Co(NOi),6HfO in 250 ml. jtj.pichler'M,2,2-tetrafiuoropropana. Imperial Chemical HfO, dried 3 hrs., heated * snru# IK hrs. at 12U*, and activated Industrie* Ltd. (by Brain G. Dutton and James Raventos). a mu** at 274*. A reactor is rhargeri with 100 g* propylene, Brit. 1,004,606 (CL C 07c), Sept. 15, 1965, Appl. May 15, 1962; 2-4 go catalyst, and 10 ml. heptane and the mist, is heated to 3 pp, Process for the prepn. of the title compd, (I). Cli at 3.9 85* b> 1/2-1 hr,, heated 5 hrs. at 85", and cooled la ruora temp, l./hr. is bubblfd through 225 11FCCFCH|C1 in a flask under to five 13.04 g. product/f cntalyst as compared with 8*62 for the "1 a packed gl*** column surmounted by a trap cooled with solid CO. (pDtnfv BDPF The niixt. was kept at the reflux temp* by irradiating with a llg Catalytic dthydrogauathMi of n4ratents to butadiene on a vapor lamp fur 7 hrs. The product of 4 runs weighed 280 g. and nickel Mi**TM* phosphate catalyst. Prediction of catalyst Ufe. was rp*L by gas phase chromatography to give 193 g* 1, b. 77*, Goudricb-Gulf Chemicals, Inc. (by Wdlwro L, Krlit and Donald of 99,7% purity. A rabbit inhaling 3% I in O* for 10 mu. then S. Maclver). Fr* 1,405,509 (CL' B Olj, C 07c), July, 9, 1965; h IV^ fur 1 hr. was anesthetized with very little fall in blood.pres- U.S. Appl. Oct. 29, 1963) 23 pp. A calidyti is prepd. cuntg. sure and no cardiac irregulanties, lo pathogxn*free mire, the 29*5-31 wt. *ye Ca, 5.1-6,40f Nt, 54-57.5'^ !*(.),, small quaiititics ratio l..C^/AC for I i* 2.1:0.3, that is 7 (where A*C^ is the of CrgOi as a procuotur and lubricant, lly t-ray analysis of turn- muiunum rotim. by vol. to fully ancsthetise 50% of the mire and ctivatml catalyst with the Ha frequency of Cu, tbe crystallme L.C.* i Om minimum comm, by vol. io kill 60% of the mice within iwim of Ca salts are sdcnufitxl as siioilar to Cad 1*04)1 and C4* 30 mitfD* Comparable ratweare; ctficr 10.1:3*62, CHCli3*fl3i* L L* ' - I 3*99 b si&iiES -sl,,; ' ...--M > 1* .. t-r -r ;-3i^r:^5 ./- . C~' ' - r':;^"i " V^ y .S3 - - v-v. ->* . Hi- -V * .,/ <_ -- A,, 1 v7 ,; W'v- ;j ~r;:<&::-3 B ^^3^ *> ` - CD - V J J 4 - ^'M;k J2 uw Dmicoi sffafaadj 13200 Vot 56 >4ppt rkmnmcd. $. TUMSltifll); cf. Cl *S. 384*.--Tbe W. UiUler. 5*-aA 21, iJ0-2( 1V0I).--Meamietnrnta id aorti (Vfcr.) iutruperitoueal l.i) uI paralytic ihellM niMi (is bibb) b MM) yAc* Th u bnuH to 14.3 Wkf. by addn. <4 Na*. Ca**. Bn**. &**. Mg*\ Co**, dust cutest, and dust compos, were earned out m 2 Auitma tungsten eartade wntmag plmls. W* Co, and To* Nb were dead. OimpurtMin with cuocn* iim nuirr mania the* ft**, ht**, Btd Ft^ obo lifnikulty mmtfd the where indicated that the dust nunu. were higher lhaa ia tuidty. Fourteen oibtf idu tetud dtd Dot alter the otiicr umilar plants, although the dust compos, were much L.D.*. Fvwk A. Smith the tame. W. Strauss TbnnwtjniiBlf ictivitf f cbm bdaitrii) peiioiu-- Analyses af tbs carhce nuuisririi esotsut af the blood cf . rulueilaa of tba activity b tbi tuiuhij <d reUtfie organic workers in a coal gas contaminated eavirooissnt in a rnmnonurti V. A. FUov. TV. Aaack*. JWreu Umn^r. ateei factory. Hwu'dJbu Chau and Chih*Waag LM Wuhan JViabi^/uU. /(> Clifin^ frb Fiv/iobb., 1958, Med. Cull., Ilankuw). U'n Him / Jhtuh Ym Htutk Put 223-3K Pub. 1968).--A tiwrowlyiittue treatment *u made No. 4, fidJ -IK tUST).--Blond CO taken hrs. after work* of 84 difldwt volatile wg, compds. Rckiia uf unspecific mg in the open hearth departmeot and at the blast furnace activity to different functions and logarithmic dependence l are O^Tv vol. % (J.G3 % utn. of hepwgk>bia) and 1.138 of activity ia bwHbgOtt senes was tested. The range of vitf.(8.R',c u(fl, nT hemathlHfl), iwp. These values are kfiaL activity of various narcotic compds. w detd. higher than thiwe cf normal subject*. Shung Kal Chan J. llradce The trend ef clinical laboratory date of lead worker* is a Experimental eoppaf poisoning In plgo* M. M, Allen metal plant. G. Caros and J. Leist. Z. Arkiliwd. a. and J. D. J* Harding (Natl. inst. Research. Shiniickl, ArbtitiHkuit II, 2,MV<IDdl) --The evaluation of 7853 Engl.). Vft. Rrctrd 74, 173-U{ 11X12),--Pigs weve poisoned bloid analvws, derived semiannually from KM) worker* by feeding diets cuntf. up to 1000 p.p.m. of Cu as CuSO* owr a penod uf 3 year* permitted the establishment of the CuCOft, or com. mineral mist. Body fluid* were esamd. fifilnwing 4 response groups; state of mortiponfivtoce; at weakly intervals; tissues and body fluids were analysed post state of itbttbuor, preplumbism, 1st degree; and pre- . mortem for Cu. The first indication of tuxteity `.os a rise plumhism, 2nd ilegre*. Thev * were *** .a. rired by V in the Cu rotten. in the blood. The (Ilk/ elm. signs were thefolkiwuigav. vaiuis; hrn gkibtn.bo.w, lf^ and jaundice, duUnem, weakness, anemia, trembling, and mpiit' 84.4% uf normal; ytbnx-jie, 4^4, 3.41. 5.U6 4.24 tory distress, Distinctive liisinl. changes were found in the X lo*/cu. mm.; luso, tippUug. 0,0.35.2, wtu 14 *.1/ liver sod kidney. Rudolph Stolen -- 10.UW cells; copropocphyrinuria, 0. <M 1*2, ao' 1*3 Hlstncbcmkal findings In binudaated liver cells. G. degrees; Pit, 0.(01. O.itiO, 0.002, and 0.0*3 mg./* t ml. Bwlrt and H. Simon (Humboldt Imv., Berlin). Zentr, idthMl. A ncg. correlation existed between age and t\e sever* Atigm. PaUui, Paikot, AmX< 102, 42D-34UWI).--Hisb* tty of poisoning, mdicatmg an acquired tolerance aid (or) chat, and histoenxymR methods were used to compare . rtikunct. The prophylactic significance of the . **e of the iftMmlfC activities of momv and bmueleated edU in stimulation is emphasized. Andrew L, Ree* s the Ever of nmmat rets and rabbits and of animals poisoned Soma implications of ambient air quality stand .*ds. with CCU, dinitioplienol, and other heputotoxins. Ui*- John K.Gofd^mtth (California,Sure Dcp<-of Public < ~'th, Dudeatad cells showed significantly greater reactions than Uerkeley). Arek. Emvironmtenlji HeMlk 4. 151^3' mmmnwclmtcd cells with respect to diaphoraic 1 and H, _ A review of air quality standanl* in California, 5 ncricun deltydrngenaae, lactic dehyUmgcnasc. monoamine municipalities, and the Soviet Ceion. 24 refemcw ocidast. and sutfhydryl groups. Xo differences were noted Raymond 2ehnp<ennig b reactinot for tod and elk. phosphatase*, nonspecific An indicator tube for the rapid determination of aniline glycatophospbatasc, fructose-t.C^ltphospUatawe, ademrune* in the etmoenhere. A. I- Bulycheva and P. A. Mel'nikova. triphoaphatasc, aderMMmcmonophiispfiata^, noitstxvjnc e.~ fti.-Kkim. Metody hiUd, i'ozdttskn- SrtJy, Ysct, Tttnir. taase, oaphtbol AS esterare* lipase, cytochrome vxidii'C. muinic dehydrogenase, and methylene blue staining. The results did not provide conclusive proof of the hypothesis that the bmueleated liver cell represents an adaptation to increased metabolic demand*, siuce. in general, itsineuiiolic capacity resembles that of numnniiclcaud evils. H, Dix yamckn^hiUd, fmt, Okkmny Trndi 1001. 5G-AI.--A mcthiHl for the rapul detn. of PhNlit (1) it taxed on us reac tion with p*imethvUmmbaimbiuhydc<lI); porcvUin pow der is iniptvgiiated with II, placed into a glass tube, contain* mated air it pasted through thy tulc, and the length of the vrllow cidond cnhimn is compared with a standard vxte. SfM*uraa IP d mist. X. V. Hendricks, G. II. CnUmg*. Two ml. of a 1% ale. rotn. of 11 arc mixed with 1 tnl. 1% aq. A. B, Dooley, J. T. (arTCU. and J. H. Katlicr (Ks> Hi* 11CI wdn. ami 2 ml. di\Uj. Ji0; 3.5 ml. of tite ntixt. are teareh and tvng. Co., Undcn. N.J.). .Irrk. tmironmfnttt i added to 7 g. dry porcvUiu lewder (granular fineness 247* UtaUh 4, Ijy--1o(1WS2j.--A review of observations * hu ISO ft), mixed and lined after 10 mm. t*n 1 hr. at /V)*; the mans and snitual* chronic exposure t<> oil Allots, max. dr>ing temp, influence* the J'jismvitv ami fluctuations allowableeuocns.. aiul method*<*f dvtn. of oil mi*t>. !** rtf- should not *tinuw 2*. A glass iu!e 4 WHl mm. length crences. Raymond Zelmpfcnmg and 2-5-2 d mm. inner diam. is filled wiUi a 70 tmu. etfluinu Tbs role cf external industrial environment in the im. -- of the Indicator powder, which i secured at both ends with munobictogicsl reactivity of tbc organism. U. Effect of cotton tampons. Tlie tubes, if storvil m a vertical pnibni chronic poisoning with CCU and dichloroethane on the in a closed vessel, are usable for 1 mouth- Air (230 ml.) it hnmuuobioiocicai reactivity in rabbits. V. K. Navni*Lii. passed through the tube in 7-8 ram. and the length of the Gipen* Truda i Prof, Zob/Urmmita 4. No. 1. UNk; yellow cohwed column is compared with a standard scale, Cf. Cl 51, Winnth; 5), lilfilbb.'--KxpU. wire cnnduetrd * prei*d. with (i.(K0afA8 mg. of 1/1. air. Results of lab, ami with CCU (I) and diehbinicthane <111 on 2 groups of rabbit*. industrial tests and comparison tables with the colorimetric Control animals were only iiumuniaed. Rabbits were m< detn. of I are given. K. Stein toxicated by inluilatkm in a chamber cuittg. 4 tug./I. of I Determining aulfatea. chloridaa. and reaisoua aubttancaa and 2 mg./l. of 11 and exposed fur 2 hrs./day. They were _^in ionospheric duat. Va. A. Apel (Sci. Kmcarch lnst, then immunised by typhoid vaccine injections, between Epidemiol., Micnxbiol.. and Hygiene, Chita). GifKw i mjactiofU, lime was allowed fur the agglutinathm titer to Santt, 26, No. 12. "H Od'.U>.--Tlie dust is csfllected by drop to its initial level. The amt. of hemoglobin and cry* miimrntatun and extd. with 11,0 as usual. SO* ""is detd- throeytet ret puiumiog with 1 and U for 0 months changed by ncphelometrv, Cf" by titration with 0.01 S HgfNOih only slightly. Clumget in the bluud albumin were charac h using a (FhNllNIlhCO indicator, and resinous materials are terised by appreriaUe kukueytreu* in some cases, whirh detd. in the HiQdnvd, rcsnlue by evapn- of an KliO eat. was absent in (Im control animals. 1 ami n in tfie early ami weighing. Constrociam details of a mkvocxtn. app. tUfo of chronic poisuning raused a sitarp depre^vun in are given. John Howe Scott agglutinin formation. In the 2nd series (simuluneiois Accidental liquid chlorine epUl ia * rural community. poisoning and the agglutmatiim titer after Roy K, Joyner and Eugene G. Dure! (ruion Curlnde Cltemi* 1st tRUtiuniaatirm (I mouth after pmwMimgl was normal, cals Co., Tftas City, Tex.). J. (htmpahmmit .Ufd. 4, while after the 2nd immuuitatioa (2 months after fshwui- 132-4M0O2).--About AA tons *4 Cli were spilled in a rural bf) it wax */M *4 the titer of tlw control animals. 11 su|w area of Louisiana after derailment <4 a tank cor. The re* piTsifd agglutinin formation much more tlwii 1. 1 caused suitant cloud of gar eventuoiix covered an area of 6 sq* S iliglit darreure in likaai eieiifdemcnt titer ami 11. a slight miles, nccnaitating the evucustw>a of alaiut ItUM* persons. bexeare. Acet>k'la4uie and choltncatrvure activiiws M Midale iprctruphotumetnc equipment, rec*ading the levels were appvtwiabfy fughrr. 8. A. Huxamt of Or 3-d h/. after tlie oicidroi, sbwwed lb p.p.m. at the Daat fluuatiunli is Austrian ainltrsd mstal hAi. funges uni 4*et p.p.m. in denser aint*. Surviving huds/i ? v u- P-,.V! ' A'- r- ' . : :f.' P-' * 'V - -. , J, - ' < ------- * - * 64.' /64 6 V-vrr^^Vv*^ \VC.V***.,?.- -'> >N V ; . 4-7-'-J^* * ff *> ; . T, ---,>f^^T-J4* --'I_ ,, T9 m 7^. i.s' i,-:~ -ff it * .- 4 < J-:.- i "" " '1 - um Mnm iitmamts.tT3i-Ta-aooaaoco9e8XKBB>iw)i. u__________ . ... __ ndM dmtoy liblawlai taforioa la day* ni 77 kakted at papillary_________ ca id rapid)/ ravened by a launaa lajeetka of ffwwdaa.bypaaia ladmad by babbling N laalaad ofO t ttaa rercatf rtalanliiad (or MJ tan, C~"*4r'"* ttaa both aradoead m, Imitiniiiif yffecta with 14.8 * 03% i af ICO altar tailla pnoaatad any rfwnee la matin. bond Im, kattey fa appem. 3 aria. Ttaa daratlon of ttaa Of 11*1 C3-. aad Nt#, tat lima aa putal *-hlt^*4*" (I I* * iaotraaie effect aid be adaad by hahMIny Itanaita aha. lataMta. Tb* taoltt tattatad tat ttac aslaik> of 98% O aad 16% N laataad d 100% N. 71m attaaalaat efftft al balk liitiitaWna ariytat ba a ratitfribatiaa el latneeUnkr K* ai byyata n ttaa an aomdt pndaat btfaaaod ttantina a Wltta ilfiilwta a K.* from dNi aaatal a miction. aad M* cmnporad with S' bat ttaa atnaftta ol ttaa cardiac actloa ttaa aaoia at bath tempo. lantaaaad vnltaye af ttaa ithaula i talltut (10 |iaa ttaa thmbold) briefly intaaiaad ttaa toa- tnetiia faa. Hntin, the i , dfact el hypaaia aaa affhettay. EdwardJ. Vantier*,Tbtaua* dll paal aad waaaf ttaa aaiaitta aaatlawvaltBfaa. Loir R. _ . aad David W. Nartbap (School d Mad-Wctt Ca aao. araibcaaUy ttaoaaaad aad hifta Ca eaao. bartarad VkyWa Unit., Am. J. Otdd. Gyml. 04(8). ttaa aaattaatila fan; laiaam, ttaa aba. tnrraaa ta lana tetat Ml-7(MCB)CBay). Tahakttrw ad cyclopropane at moderate taypaaia aaa Bat atgaifiBBatly dlflatat Hoattar, ttaa laotaaa eaaeaa. bad aa effect aa awrioa actiritr or t . tatalla taittatf Q laiataa uia--iil aaanitrtataiaal ttaa ptiileoi bade eoetrwe- eaaeaa. daoaaaad attriaa aaaia taoii aad atotaa eoatnetik tiooa raemad trrattr in krm Ca rrmrat TtaiaaitauHaaia biiliitd fagMM. awrilhi^a waa^ dfabmaoAnaa tan * tdanUttatly eooaiataM wltta ttaa Ida that ttaa traiuaeat cardiac rtliimltm ` anh Na barbital aad naaittad with 6 daily adattadtaypaaklaaMdiatad by local itkaaa ad aatactaad tmmtt. r tajifrinna at lagr.dlrtbylallbm__triil. Ethyicfcla- Ocovya 11, Hocfciof dda aaa dmaniy taadiwtlya at hm , wbilt taittatf lanb Iflatn ad aadhmt ataaataartlwl aad a* atyiaineytllaa aa ttaa Ettayl ctakaide, at--aadaaaa actWtlaa ad rat Uiat. Kobccto Llama* aad finxttlna ttaa Hood pwann to am; attaint Comm daaia /art. Bid. (Owe. Nad. Met.) U(l-2), namai'*lllly aaa not atadiibad bat ooiy iHminbhnt oadtf that l~A<UIMK3paa); d. CA 01. 113031; (oliowtatf abatr. Wboi*. `!7ktaloteattayina waa ladiKtiyc aa Blaine aa- Irrcr boaiotcaatce froa lata reeemot 3 dally lajittlpaa al Na BPJN Btacnobarbital <J7int./kt.) (a<4 day* bad add DNaaaaadodd aa biliary KNaae lertla 263 and 35.0% Mfhar ttaaa ttaeae ol ttac aotfol B. H. Pak, S. 8. Hoot. H. K. Fata, * trap. Oiytctncydiae (40 otf./bi.) dmlbrty almbilamd . 8, tL Haas (Yaaari Uatr. CatL Mad., Strati. Korea1. ramrd a 37.77% dccnaaa la add DNaac aad 3j63% ta add ttaa. J. 1UXU. eM-MUOBMBat). Ttaa oBaeta ad Na BNaac. Ttaa dtmmtnlal adect ol otytctneydtae fianliiailal atotaattoadt (l)and ol addtaaac rtaaaf aa bile aad IHIW netta ttac cdttet al Na-baridtoiata ataaa botta were jojeoad omaltaaa joke letioa cat ttadiad la Na ptnbarbitil anratarriaal aaaly, dcaaadac add DNaae aad aattd RNaaa aathtttiaa 6M don. Ttataty ta05mt. <d '/tat. iaamaad ttaa bile floa ilichtiy__aad662%. trap. Nataarbatoratcmay taaccapccKtictiTcactlim. bttjab^lta^puaadjSa^iajaajiJMII wnita d ^ ^ ^Fdia f (iarfawl taw waaacrracipaaitd Sylqowiacd bllcaad paic imlta aadaaaa actMly d rat Bear liana. Bimailn Ca Jake UCO.' aad tab Q" aad rimaaaad pawnorlr Cl-) waa Kebcrto Awaits itt, Bid. (Van. Nad. Mat.) ditfwaecd by I. taeta ttaot (or a tma How, HCGta- waa lowered *5(1-1). 7-WlB0K8aaa); d. ptandiat ataatr. ddaibdainniaa '-a- aada~wibninl. Whaa pkaaaHCCta-scataariad by t*d of 50 of. al otytttrweydme to iota (150-300 t.) deanaaca (4 '-J ~ ' Atftai addada altaloda, ttae Sow aad HCCta" la talk aad tan. later) ttaa aaid DNaae activity d ................... ~ paaanatia Jdae wet* (oapatkaal ta piama HCCta-, avea la by 29^4%. Ttaa rcnlta arc roiwatr with ttac iact that -;.\S tkwmcd L Ttak appartat depaadam ad flow aa pkaaa IrTTfriUTninbnat htinaaiia itt--it t~tflTT HCCta- waa modi more dotiaet la (wnmaa ttaaa ia b8e. Iw. aAect aaoed. wltta ttaa tttankboa el protda ayotbaak baa d Na taontbaiMa doatakd ttaa nta al talk flow wlthowt__by ttac ttcrocd (Cd >1.1000k). nlln `wcwlin iroinmi to I or taeittk, Apponatly a Sana fraatftita af atottl D-17. A. I. Kaa'yma. Aad ded HCCta- k aat lonoad by orbaoie aa- HmM. Abad. Noah Vkr. SSK Imd. MOnttad. 1PM. M-00 ltariw|w ttawv an 3 kwaatte pwncmtk (Rue); d. CA 44. 7335c. A ayct. pevpo. nyettk D-17 (1), .ta b O' aad aaatt. HCCta- depewdeat oa wtaKta didravd ta boctoidm attlclty aad la eone pbr HCCta-. awl ttaa nltatr talyta la HCCta- prodaecd by pnpaftkairenonnatai A. watbokudlm ttacewbare te aataytkaac aad tow tat C3". Apparently at aae atapa ad - ad a aew mycctia tmdacar. Ttac m.p. al ttac 1 aratak ttk cantfing. HCIA" k caawmd in r>aat lor Cl-. 143*. lower ttan ttae m.p. el aiyeatk A (17>80*). t _ HFJN aloinar ao tohlbittaat adaet aa poalt al AWoi, bat waa i tab a( tw iknaMadoao, fh^kaaadaa active ttaaa nyeatia A wkb mpaat ta Bardta jakitaic, 2. Linaaci. H. 8. Batata aad R. P. Lkk (Van. d aalbraru, 2. imiclwiiai. aad Cnjadaibiiaw di>bttataat. J , UibaaatK Aw. 7. Kw. An. 37(110), 31-tafiMXBa(K The mac. takrabk daaa all ta wkba anew warn 50 ms./ka. J aalBB, 4i we-/tay- daoaaaad ttaa ayabdla, tank.--(staple latnviaauc kjectiaa). Aa eye atatamt ta a palyvttayk aaa palm pi laana, aad ttaa mna arterial prmwv. bat did aae cac tlynl taaaaaaaty. 10 y l/. braactatataaat eatapktc reorrery etabiataaof.a tbe hmet nm la daya, Ttiduinaattaaa 1 Fkptanakoe bad aa adnaoiytk deoeaagd ttaa ascaa al (Bam pin witb eyea lalccMd sritb dlptatbtfk bactom. 1 taad a pwaoaaeed aattlaainr aettanty f--ra ijaW aanaan Mtatfkl ptesaaa. Neittatf May had efcaidcaat panaysopattao. W srtiita mka. Pnn 2^. 7*., Bid.. B. 1PM, Ataatr. No. lytk or yaaplaade bkatba dbcb aad they did aat affect ttae MHV. MV3W aa. Ttaac toattacitfdiniaaiwkraywcman / Actka d Pdeydk aaiMipriamata aa **ydtayypa tel etataerproa btdaaad hyyanktfmk la tatataka. D. Lacw aad M. Tat_____ (Saadoa A.A1., Baaal. Swiu.). Arc*. c(W. patM. Ptaan al mabal. 2S2U), 3-IOO(iaMXCtf). latrastuoaa kjccttam al -.v/a r.: -^3 . ' '" a. Jon Codan Ctaijatf. Aaalcs At, (Mb. Aon, (taa. CUk IP,C---M--X--1--H---4-X--M-- 1--.-1--0--C--5--K-Soan|. Pnikm (34 lwv.) ktiwckw td ' (1) at ttaa rare al 4 a(V .... . fiaptaattfy ntaa foUewiay inyection d frAiydroay. (SdiT) daeraaaad Mnlbilj aa witb D; daaa effect J a*. hunokiHc A u. dibniytiiBtt 0J am, dfiROnniat. or * a>(. aartfipryttae/kc. 90 sain, titan aa kuartiam bpetta ol 15-00 my. II kpiliiia jii y |ini|ikaa (l)/kf. patcatktcd ttaa lew by 1 in nbbita; * my, amitriptyliac/bt. had ttaa nm ppirnllately Meet, tint only if Injected at kaat IS lira, baton ttac I adsmnitratlaa. ThieriAinBi (1 my./ky.) partmDy btaltakad ttae I krtnml lupcsUicrmia. cep. il admiimured 30 Wktkai wen ratbw aUkr hot with AHT neither teterser aw r ena. beiere L Sin the Ltadoced few w poerrmattd by . - lacbypbylatk aapaand aad ttaa effacta wen aat attend by ttae osaanaaimc --u-- inhibitora and waa radueed by aa aataeaatait pwias admWatntka ol ahtatf IwO, Vartaaaa SAIT enter- d aiatoaia, a rdatka between ttaa tawnaae ia hna serotraiin anata (darwd; dabutylka) ttand aa effect aa ttae aMia aad ttaa lever mat to etie. Ttac potentsntina ol the fever by Wbtlliry rvenltl im admlnbcvtioa diet 64fT. ttaeeatkk prtmnnts may indkatt nn jntericnaoe by ttaeaeooetpda. _ t; Ceerye M. Haektaiy with bratat Miptaaia. 10 rtlenin*. CMJO Macbaaiaa d iba cardiac attasetnt affect d taypazla; ptayiln--- Ttae affect al cardiac ylycaaidea aa iadoeed taflax bradycardia. **"` -`H laticM eaa (liatPiaralailtal ktiifamn. Maria Aatdica R. Bactbke and C. Schmidt (Unit. Gocttinren. Ger.). Arc*. "i paaadm Praile. Aaaltf Pae. <?atw. Pans., Vasa. Chit l, Eipd. pUd. PbanaetaW. 2U(6). 403-79<lMXCcr). Rrttee 10A-l*<iaO4XPlsb. lOOSXSpaa). Tbe tsiftaracc al variooa bradycardia waa induced ia anttactlitd cate by taicnaaDt ttaa ,,-a? , `y .i dnta.aad eeptL wulrinaa oa ttae heart atiaitikrit effect! af pnwan ia ttac perfused carotid sintu or by elec, tftaauktka taypeak la kaiatari heart prepay waa deed, la isolated ruinen 4 of ttae 1 nerve and (or) the afferent vayaa 1 Keflex ply aad cat atria, hypoxk ludutad a transient tasertaae fas rate bradyraidie wa* enhanced after Intravvaao* admmlstntma al aad aaipltawk el cardiac cewtnetkoi, Pierluaa trratmt d 2<>r dkitoela/ky. or of 10 7 t-Unphaattaln/ky, After bilateral ttae aaimal with yaaacttaldlac ar a mettayidopa and adda. d vaxotamy or blorirint af ttaa efferent vayai wrvt by intravenene J'^' ami or hwamattanebm to the Tyrone aota. Inlection* of 0A or 3 X 039 m(. atropine (wbkii btaieha only 1 a bath ftf ttaa laektad atria riyaldcaatly bkebad ttaa ttaa efferent anvaa)/hy., ttaa peraatlay bradycardia waa not 1 ,3_ 4 ! srtrie f v' fh- . i' -- r -- UJiUPP! <k>i J I'" -.Mi. 1 ^2 `K if "8 arA TteS jssi - . '.4 I< 31 fi W o-->a N3 CT> Ci -s'. 3-', -r.'-."A, . "7* r- 30 fio (n 63! .703f wnwajjaani*.. k.jals? m* Obrmitml AkrtemU 7040 Vuf 65. 1W *--AUfHATK COMPOUNDS Unuwcf t. rmaaou aao raiit t tuj i tmt ctMam4iinau. Chfotncarboua aad ckftorobydrocarboa* eilyf rhlorkia. B. If. D.W.P.tUfUw. KvMtkmtr E*jd. Chrm, TttknM..lU U. M I'ilt#s. KtrkAJikmet Lmui Ckem Jmd Ed, 5, iW-13 I, 2X1-40 IWUXltDt). A mm am chknutnl dnm, at * ihtfMyEfic) A review on the phys. and them pn,prrties Mnl or lyatWtic bicker pai.ftin, rntboat muil to oiinlw (tTpril *4dn. to the double bold, simple repUermentv of Cl. tk punt mot mol is naraaUr oM or liquid, intruding putr- f'lematson of *Uyl esters sod *4 N cotnpdv.. and vynthe*as of tin, mooul.. rcoaanic oipirn. hondliot, Imti, aad am. iW r(<inpifi imti*,), mamif. (imertUiMi, reactvjn v^rubles, cm. (dmocti. VlANIl2i practxe, feci prepnv icactioo 'system, and |*oduri recovery), AMMMtlCc p-pu,ti* (a> dnmml7 iwitu. v>. safety ami handling (lotaity, prca|iit,iury oir^iuhi, aad U. I W A. P. LuofVb. HrfttptnTubvlk* i Stilt- remedial treatment J, end use*. 25 reference*. VN )Z kkim.t Akmdi<. N.mi utt. SSK, gap. .Wm*h,w*. .St. 140S. Chlorocarboaa aad chlorobydrncsrbons: ethyl chloride. 54<XRnia). A 1: l :0<6 isooctanc--octane--noaafte miit, vi D. W. F. Hardie. Atk'Otkmer Emyti. Ckem. Tt*k**4., 2nd Ed. Kpd. ta a cohtiM of 6 m. length ftn4 )6 mm, diaro., N timer itu 3, 14W(lJ)G4gEftg). A review *n the phys. awl chtiu. prpef- priority OA l./min., Wfccatstooe bridge ctmnl 170 mi., re- ties, mamif.. (MiMuk aspects, standards, handling, tokinty, w% smritjvtty 50 bt. Sample* (3.3 cc.) wen injected it and use*. 3U reference*. VNJZ 112*. and tbenapmenu wiretuDectfd and fnueo in |kn tube* Chloroca/boof aad chlorobydrocerboa*: dichloroethyines, t 0*. The yield of the components vu 65-607f, although by D. W. K. Hardie, KirkDtkmer Emytl. Ckem. Tf(hnoi.t 2nd Ed. coadesmtioo of the vapors, the yield could be iaerwMed to HO*,,'; S, 175-831 HXklX Eng). A review on the phys. ami chem. projv the purity of the collected compds. was 90.9',7. BNJR ertics, manuf., and use* of 1,1- and 1,2-dichloroethylenc. It) RflftCdoat of active nitrogen with organic mbttrate*. IV. _ reference*. VNJZ Imwmi. Tcrukiyo Hana/uea and Norman N. Licbtin (Boston " Tri- sod perchlorotthyleAe. S. A. Mitlvr. Ckem. Ptecnt Umv., Boston. Mas.). Cm*. J- Ckem. 44fl0fc 1230-2(lUGd) Eng. 47(6), 20K*75( lP0A>Eng). A review of processes fur the (Bos); d- CA SS. 17022c; 64. 110704. The ruction of no- manuf. of C1HCI1 aod CiCI. The relative feasibilities dv|cnd nrtae with active N at U0*/2 mm. was investigated. Product* on the availability of raw materials and the utiIiL,ition of by trapped at -190* were HCN, MeCH;CH, CH,;CH,, C*H.a products. 18 references. Paul A. Haas HCiCH. propyne. EtMeC:CHt, (CH,:C11)*, and propane. e Chlorocarboa* aad ehlorohydrocarbon*; chloroscetylenes. Mooomok products trapped at *-78* but vola'ilr at G0*/0.0i D. W. F. Hardie. A'irl-C>iAwrr Encycl. Ckem. Ttfhnnl., 2nd Ed. mm. were 0-metbylpyTTole, pyrrole, NH, l^yanoiseprcne. and 5, 3T -A( 1904 X Eng). A review on the properties of nwno and at least 12 other unidentified cocipdt. Tbe polymeric product diehloroseetylrne. 5 reftrenev*. VN*J2 was a complex niit. which probably contained CN and amino Chloroeartraoa aad chlorohydracarbont: chloropreo*. P. S. gnupa. C. M. Bums Bauchwit* (E. 1. du Pont dc Nemours fit Co., Inc., Wilmington. Studyof bslnofittwu oxidadoa of Q-huteB** to 1 .3-battdieoe Del.). KtekJitkmer Encyel. Ckem. Teeknml., 2nd Ed. 5. 215-31 h tho prtaoaco of ataam. 1.1. YukcTsoo and . A. Boguslav- (!9A4XEng). A review m the phys. am, chem. properties tin- skii. if, Lrnbm JChim. VytmkpmaUkmi, Seed*a., Veeemezktk. Untw. eluding reactions with O, S, SO>. NtO, halogens, H, halidts.. and 1664(3), 03-6(Rim). The effect of steam concn. on osidn. uf a* hypolialous arid* and esters, DielvAMtr ad*tn>. and dnueriu. butenes over newly developed catalysts (oxides of group VIII tions, free-radical reactions, and p^yinensatNm), prepn. (from modified by dements of croup IV) was studied. Tbe raw mate* . Cilii via monovinylacetyknr, butadiene, butane* and tmtene*. rial was aa industrial fraction of butenes with the compn. Ht a and l,3-diehloro2-butet>c). industrial manuf., health ami safety 0.1, CiH, 0.3, COU 0,6. C*H 14,1CH 32.0,2-CH. 63.4, and factor*, and isomers and hontoiog*. 73 references. VNJZ C4H4 1.6 ncle*/(. Oxido* was effected in a conthmousAowapp. Chloroearboua aad chlorohydrocarbaa*: trichloroethyleaa. at 050* and a 1:2.5 diln. of the butenes with air over t ml. cata D. W. F. Hardie. Rukdiikmtf Em\ti. Ckem. Tft'kn**!., 2nd Ed. lyst (particle die 2*3 mm.) in a quarts tube (diam. fi mm.). 5,1N3-6* 1964 XEnc). A review mi fdiy^. and chem. proiwriws, With an inocasc in butene air-HfQ mole ratio from 1:1*0 to -- mamif.. economic aspects, standard*, handling, tmiciiy, and 1:15J, the 1 ^butadiene (1) content of the contact gas increased use*. S3 references. VNJZ from i3Jto2QJmde-%(baairdry gas). Curves were obtained Chloroctrbons and chlorohydroearbous: mtthyieu* chloride. bowing the dependence of total butene conversion and 1 yield D. W. F. Hardie. Ktrk-CHkmre Emvti. Ckem. Jnknil., 2nd Ed. per amt. of passed and decompd. butene on the steam concn. in 5. lil-UX 1904 XEng#. A review oti ihcphy*. aivl chrin. pi*dhf- the initial mist. From Reft Zk.. Kktm. 1666(4). Pt. II. Albstr. . lies, mamif., eci,nnmc aspects, ktamiards and analysis, handling, No. 4N7. MVRK * tuxmty, and uw*<. 4d fvlitmcrt. V NJZ Chkortoadan toaedas la the mmufactov* of hnachlorobon- Chlorocarboos asd chiefobydrocarbOftS; cldorofonn. D. W. sane. Jcrty Jaworoki and Tadeuas Masonaki (Kaiedra Tech- F. Hardie. Ktrk^Otkme* F.nsyii. Ckem. Tt< hnni., 2nd Ed. 5. ad. Cbem. Org., Pnlitcch. SUska. Poland). Prumvtl Ckem. 43 119-27(1904 X Eng), A rv\iew on pliys^aml (hem. properties, (2), 92-4(lO04XPol). Continuous chlorination of o-diehloro- mamif., cconoime assets, standards, ffhalysis. handling, tokiv- bento* in the gas phase (at 300-400*) and in the presence of a _ ity. ami uses. 25 frfoenn-s. V\l/ fixed bed catalyst was investigated. The catalyst used wav in* Chlorocarboa* aod chlorohydrocarboas: tetrichloroeUivltne. expensive activated C, Carbopol 2, in the form of irreguLar D. W. F. H.srdic. KttbAJtkmer Ckem. Tetkn.d., 2nd granules, about 5 mm. in dinm., with a density of 230 g./l. and a Ed. 5, 195-2l)3( I!X>4X line). A rrvn-w oq the phys. amj chem. to* surface arra of 157.7 ra.'/g. A uniform temp gradient was properties, manuf.. economic aipt^ts, standards. Iiandlmg, obtained when the upper part of the vertical pipe reactor was toxicity, and use*. 15 references. VNJZ filled with less active catalyst from a prevhni* charge- The / Chlorocarboa* aad ehlorohydrocarbon*: other ehloroeihauet. use of a partly deactivated catalyst resulted in a total absence of D. W, F. Hardie. Eifk^Hkmrr Emytl. Ckem. lethnvl.. 2nd Ed. catalyst baking, even when its load was increased by 40*^. The 5, 14H-7IX PXHXEng). A review on the phys. and chem. prop reacttoo product contained more than W'v of hexachlurvbraiene, erim, matiul.. economic kxpteii, standard',, handling, tokanty, hnirfn some pentachlorobcnreoe. A schematic diagram of the and use* M 1.1- and 1,2-diehiorotfthinc, 1.1,1- ami 1,1.2-tn* equipment used is shown. Edward A. Ackcrmann rliUiethanr, 1.1.1,2- and 1,1,2,2-tttrachiotoethanv, p*nta- Chlorination of isobutylene to methallyl chloride. E. M, " chloroethane, and hexachhauethune. 101 rdvnigrt, VNJZ Mokrii, Kh. 2. Kotorich, and D. K. Totopko. Kktm, pram.. Chlorocaiboa* and chlorohydrocarboae: carbon tetrachloride. Infirm. Nmuk^Tekkn. Zb, 196*4), 7-10 Ukrain). A 90.Src D. W. F. Hardie. Ktek-Otnmee Eneyti. Ckem, Teehnol.. 2nd Ed. pure isobutylene (I) was prepd. by dehydration of Jerf-BuOK 3,138-31X l9tV4XEnx). A review on the phys. and chem. proper on AliO. at 350* with the 2 l./hr. rate of t formation. The ties. manuf., economic aspects, standards and uuly>u. tosi- otalyst was regenerated at 50(^20* for 3 hra. in a stream of hot _ city, and use*. 73 references. VNJZ air. Miming 1.2 mole* 1 with 1 mole Cl *t 9CM00* gave a mist. 9 Synthasi* of triaikyiamine-type extractioa agents by the Hof of products, which on rectification at 7(F-2* gave methallyl mann reaction. B. N. Laskorin. 1). 1. Skorovarov, and V A. chloride (D), Tbe fraction collected at 72-5* consisted of 95.4 Semenov. Zk. Pnkt. A Aim. 39(5), ||GdX Russ), ratio of U and dimethylvinyl chloride which were difficult to Lab.- and bench-scale kg.) method* were dvcrdwtl for pep. A lower l-Cl molar ratio caused addni. chlorifiatton of the prepu. of R|N, where K is CrCti. KBr was prtpd. by products and a higher ratio decreased the yield of 11. At t*0% -- bating a mitt, of KOll, HBr or NaBr, and IliSO*. Hie org. a 02-72A% yield of 11 was obtained. BMJW \ phase (ibuinnl, contg. 75-80(*o RBr ail unreacted RUH, wax s Chtorocwbouv aad chlorohydrocarboaa; vinyl chloride. | treated with NH.OH at l<X)-lh()*/scveral ntm. The \ D. W. F. Hardie. Kirk4Mkmer Eneyci. Ckem. Teeknit.12nd Ed. | yield of RiN inereasMj with decreasing Nlfr-KHr ratHi to 2'-3' I i 9t 171'4J(1204XEtif)* A review on the phys. and chem. proper-y and with increasing tnup. The yield was not affected by NH,0H i tie*, mamif., economic aspects, standards, handling, toxtrityA tooth, or me ut R, The ywld of resin began to increase at v aad use*. 38 reform. VNJZ ' ^ 180*; the yield of solid product, probably RNBr, increased ' Cfclarocarboao aad methyl chlorida. D. W. P. Hardie. Ktrk^MMmur &*tytL Ckem, Tttknmi., Smd Ed. f, 100-1 l(1604XCog). A review on the phys. and cbem. P<P- cfiir*, mamd., economic Aspects, standards, aaalysis, handling, with decreuuflg temp. Ihe starting condition* of ammonolyns breame milder us the batch ute miTva^ed. because the reactem is esothennir and a large batch providid a larger proportion of the required heat Uian a suiail batch under wuular conditions. A toxicity aad use*. 43 refereace*. VNJZ tyincal final product of a Cr-C* piepu. cuntoiucd KN G^U, 1r. ', i, f".- vy-.- T i < , -2. : ; * r:4 r. ': , ' ' fn. > ^>,J 'r-i\*- --J ^ hf-,V. *-r *:'-;v^I -V'-- - 7^*=^'* -..' V'-jV .' -i 15te**-,sji,^i ' *C' - ^ --? . j iji. - r ' ^w-"^ . , >, v-~- .-. ' 't, .v =L^ - '. <,- - ' ' . ';" " <w.`,, wfW?w?B- -..- J;.v - , -T ' ?; _ - t ' ' 7-, -'.Vi* , 'Ci,- ^'-" ^Sr'V-.T4'V *" * ` 'i,;-1f-'*,"w*T^'*7* -i 1 -- * .-* '- K' v- 1 -*.. - ,,:s 7? ; ..-..^J-V, .;t - .^~ ~^r 'a 3 "o ' "*^=:J"..'.-; J<' v*' `.1.. 'oai,. .*.- -j v :- -, -) . , -'\\'^\- - * ^ -L* :-*3 v- ^ _si\. M. Mb IM7 ill* (Mr. C. V. Montana. Ml. Z*. ik*). 3*41 Mtbd mine rets that osbrsf rebr predktiwg the effreta (IMBKAnaoriaa). U pwvtu-- Ka4 fe m nuUM <M of ebremr treatment with psyebBtherepevUea on the mu (am Ik dacowra. of pwiilw haacakraua by|wnaui with cMm- ky of other nwtiinna) asrots ia described. Romka obtained by IMiaa. Tik pww eaa ba iuonrlal *ad Ikt pmtna a*- thds method showed that aorertptylme, like amitriptyline, m taM b n> npldlr rMowd with bypanlfttv aka. by u w hanred tie tommy of most cerebral depressant* in on additive kwn aakwn. Mia nad* ta tlaadib Ik indwm gt manner* Both of the nntnkpreasivc compds. markedly pausu- cbVaufMua ud bypaoaMta oa cathcpaia mri *ctv iact- ted the toxicity of physostigmiav ami to a ksaer degree ptlomr- ilulWt aad It la nifirttUd that th* aiaat lotponaat latter la tlm pine* Eph^rine toxicity was significantly antagoniaid by --HtotM la related ta the tranaaininaan. EqHi. ann av thymoleptic pretreutment. The Ust failed to verify reports that dotted ada| aonaal rata (control) and rata potaonsd with chlwo- tlie trirydic antideprvaaives dangerously potentiate the toxicity prttaa (S mt./l,, 2 bra. daily, 2-3 month* >. The attivitka ol of ale. or monoamine oxidase inhibitors. Results indiaUri that (hetnmk-aialacctic tranaaminmae aad (lutaiaic-pyntvic tnna- a variety of medicinal agents rmit be used in the nortriptyline amizmae vere maaanrrd by mint tbe Heitataa and Frankel treated pottrnt without any problem of signifimt drug inter method (Cd SI, iraOl) and ue ttpreaaed in Vmblmki unite, actinn. , RCYG Tbe octivitia of tbe enzyme* doerraaed 10-19% in blood, liwr, UMf Chloriaatnd annisoo and their sanirery-toxkoiofkAl aad Udaeya and 41-M% In the rplcen oI pouoiwd anitnala. to characteristics. G. D. khatnuev. A'4*m. Faktory Vntthm. la tbn crate, tbe deertaee la enzyme activity in normal tiieuce Srtdy % iAA Gifin. Zssrbse, ife^rew 1965, lU^-KHRuaa). waet.7-6.4%and la pottoned aaimaie2.3-7.1 %; in the epleen the Monochkuoaniiine is used in the production of inseetiddc* and dccrcaee waa 0.4-0.&%. Hypeaaliiteaiaolmten the enrymie ac dyes. n-Monoch!croamlaiie(l)andp*rDnnochloroamliiie(Q)dis- tivity: however, tbe eombiaatina, hypaealbte-ebloropmie re- mlve ia HvO (5 g./1.), in which they cause an unpleasant taste atmea It to tbe Initial level and in aome caeca even a hither level and odor. The odor and taste perception thresholds were la reached. ChhMuprene doea not affect tbe activity ot pyridoeal and 72 lor 1 and 1.5 and 3-6 mg./I. for U, resp* in a coocn. of pteaephate. Theae naailta lead to the aeouaption that the in. 150 mg./l., I and II lowered the B.O.D, of water. Threshold hiUtary action of efalocuprene can be explained by ita reaction concns. are 1.5 mi./I. for I and 0.75 mg./l. for H. The L.D.w with the protein part of the enzyme. L. B. Bedirhian values (stomach administration) for 1 and II. resp,, were 1104 1331a Cbaocaa ia tbe eatarinad fatly acida aad cbeleatarel in and 401 for white mice, J104 and 368 for white rats, and 750 a and liver tt rata titer application of orotic acid end hepato- and 350 mg./kg. for guinea pigs. A ^month sub-acute cxpt. ' atueaa. F. Muail and J. Sueva (Skoda-Werke-Kranh- conducted on white ruts with stomach administration of 0.1 . Plren. Czech). FetU Stiftn Amilrukm. 6B(0), 748-30 L.D.w levels, caused the formation of methetnoglobin and re (lVMKCar). Qaaia ia tbe aeram and hepatic levcla of cholea- duced the hemoglobin level and the erythrocyte count. From tcrol and cateri&ed fatty acid* loUowinz oral adminictmtkm of Rtf, Zk., Khuw. 1966(8), Ft. II, Abstr. No. 81414. MYRK CCla (OJ ml./kf.) for tbe intmperitoncmi adminiatration of etbio- 1*17* Toxicity of thioaceUmids. Z. Hnibau. W. Gmdraan, alne (290 mc./kf.) to rats were in some cast* normslited follow, A. Slreevs. and M. Lubran (Umv. of Chicago). Lab, Jmn$t, 15 lot admiaistrmtiOQ a4 ontic acid (100-250 mf./kg.) (tiven (11), l748-60(1066)(Eng). Thimcetatmde (I), fed to rets in a a dtber I pinativt or u t tboipcutk trot. CMJG diet contg. 50 mg./kg. body wt./day for 5 days, produced high |Bl Ant* (boom tsd ret) ud ihort>trm (ret) tosicity enitn lactic dehydrogenase levels and evntrolobular necrosis of Mm m MyliMM fdycol UipIthiUt*). D. E. the Itvm within 24 hrs.; tbe entynie levels decreased aad tbe Kan* Patrick AM, ltd P* A* Faarwcttbcr (British Ind. Biol. necrotic areas were resorbed within 3 days of feeding the diet. Bm, Asmc. CtnhftltoB, Eaff,}. F&d T*xifd. 4(4) Severe degenerative changes in the kidneys, hematuria, and in TW1 KlOeOKEnt). Ante ud hon-term frediax stodire hivt creased serum urea N and serum creatinine levels occurred within bM revTscri out ow t nnpie costs. &D% dibstyl (dicthyleoe xly* 48 hrs. of treatment. The lethal effect* of the *bnve level of I oil bbphtiMkt*) (t>DGB). The ktreparitonrel L.Dv* in both were correlated with the renal damage. Excess dietary casein list ud rets n khwk* 11*2 This dose whn siren hydrolysate, methionine, or guanostnc reduced the mortality silly wss tokvntcd by both specks without ill effect. The and renal toxicity of 1, although these compds* did not prevent tedotr by other rente in mice *u cuhsnctd when DDGB w the nudear and nucleolar enlargement of hepatic cells and of the sdMnnl in imhii nil (VI" ml /ml ) U s 9(M*y study cells of the proxunal rnnvnluted tubules of the kidney occurring la rets livoi dkUry lmls of 0.0 (reutral)* 0*25. 1.0, and 2.5% In treated rets. 67 references, BPJN DDGB* rifnihrent crewth retaliation occurred in both sexes at 1338k Poisoning by frets. G. H. Gollagbm, J. H. Koch, sB keels spirt frere suits on 05%. This effect wns attribute and H. Hoffmann (Uuiv. Sydney). New Srienfisf 31(610), 412* sbfc sc Iwt is part, to reduced lood iotshca Jthre.vh this effect 14(1966)(Eug). Acute and chronic neuromuscular disorders wm leas suMd is femais. There were so honstoloeical occur in sheep feeding on the pasture grass Pkaiarit Juhrrvra. ctaimes or effects os kidney function* At the 1.0 and 2.5% diet* This grass cuntained 0,3*7 (dry wt.) tryptaminc alkaloids. sry IcreAtp the relstire liter mud heart wu. in msles and tbe rela* Tissues from sheep undergoing acute poisoning showed no histol. tire brek wt>* ia both sexes were suenificwntly imrresed. No alteration*, whereas the brain and kidneys of chronically poisoned pslhoi. duio were found that could be attnhated to PDGB. animals allowed deposits of green pigment. The pigment waa Is yww ( the effect on trewth st the lowest dietary level of noted in the mitochondria cells of the mid-brain, brain stem, and 0*23%i a Ducffret level ia the diet of rats for W days could not spinal cord. It ts suggested that these changes are related to the b established for the particular batch of DDGB tested. ____ oxidative deamination of A'.A'-dimethylirypunune and 5'tne- RCTT thoxy-.Y.N-dimethyltryptamine. The protective action of Co tSh P'r^^i of hydiwxocoboUnifi with thiols. N'onuan against the chronic form of the disease, reported by others, may AJket, Thonus MedwkB. and T* J. Potnanxki (Mereh Chcm, be related t tbe prevention of degenerative changes iu nerve Dir., Wreck h Co.. Inc*, Rahway, N.J.). 7. Are. Chrm. Sec. tissue or to tbe acceleration vf alkaloid mctabUiam. 0X21), 501B-20(I966H1^ije). llydroxocubalamin reacts with t --W. L. Downs (hiui curepds.p as exemplified by xluUthione, to form relatively < 1239} Vinyl chloride; industrial toxicologic aspects. !. ft I; 1 hire coordinatiott ccmipfexes. Previously reponeri 10* j Grigurevu and Ch. Tuba. Are. Ckim. (Bucharest) 17(H), 49fr- ceuaistcscacs in the fcwerelity of this reaction arc explained in i 50i;iMftl(Rom). A hypothesis was put forward, claiming that Unas of tbe -i**-.TM* rok of thiol compds. as complesinx and j CH:CHCl (I) could react with HiO at the level of the hepatic roMinc aicttts* RCJC j cell, yielding ethylene monochlorohydrin, which could be oxw UNi Noirntntk aiacts laducod by ilkylatlac scants. \ dized to chloral and rhloroaectw acid (II). Q could be elimi 14. G. Dooelli, R, Romo, aad S* Garattini. /. y'Adrre. Pharma* \ nated as such in the urine or be mtubolued further through ami- of. 11(11), 70O-2(106d)(Enx)* in decrenstac order of effective- : nation to glycocol. An anal, method was developed for detec ocas, DL-tryptophan mustard, a^ureolysKie, clyesne muurd, l* ; tion of II in urine, assuming that the only other source of Q urcolyuac, ni --miljiinf and akuiac mustard produced a ; cotikl be massive ingestion of wine yeust or inhalation of trichlon^ typical patten of acuretoxadty when administered intraccre- I ethylene. An aliquot (200 cC.) of urine, acidified with 50% braUy to rets. The typknl pattern of neurotoxicity included a j HS0, (2 cc.) is extd. with Ei0 (200 .), shaking vigorously, hteacr time of about 30-60 iW0n followed by signs of centre! i and settling for 24 hrs. The ext. is dried (anbyd. NaSO), stimulation, incoordinate movements, sad stereotype behavior. ^ evapd. to dryness under reduced pressure, and the residue is dis aad rariing with donic convulsions aad occasional tonic exten* > solved in 50% aq. ak. min. (0.5 cc.). One drop of the soln. iona* Mannitol mustard, tetreminc, cydophosphamidr, and i (25-30 *i.) is placed on Whatman No. 1 paper strips (25 X chlorembudl were not neuretoxic when administered in doses of 3 cm.), dned, and chromatographed by ascending method, 100 v/ret. latrepcntoneal admtntstretion of Na phenytuin < 10(1) using as elutaot the nuxt. NH<OH*HiOH-U^) (1.31:4) for a mg./kf*) ares ineffective in preventing the neurotouc effects ia- period at 6 hre. The strips, dried in air, are kept 24 hre. ia a dueed by the alkylating agents, whereas N phenobartritone ctmcd. XH sim. heated for 6 min. at HU*, sprayed with 0.1% bowed a dear protective effect. Cysteine and thiourea (1 g./ ninhydrin in McOH, and dried. The Q is indicated by reddish- kg., intraperitoneally) were also ineffective in preventing the nolri spots. For distinct development, the strips are sprayed aeumtoik effects. CMJK finally with 10% Cu(NO,)* (camune red spots). Tbe R/ at 24* 1213* Effort of chronic nortriptyline protreatment on ibo was established with a soln. of 20-30 pg. It/cc., as 0.80. The aawto toxldty of various medicinal agents in rata* D. B. Meyers. limit of sensitivity is (l.t pg, Q, and is improved by the use of Cu- D* O* Kanyudt, and R. C. Anderson (Eli Lilly 9r Co. Grctniidd, (NO|)i. The ettn. of 11 from urine was demonstrated by treat Indiana}. 7. Pham. Sn. 55(11), 1317-18(]6fl)(Ein). A \ ing a sola, of 25 #g. Il/cc. in urine as above, cutting tbe com* .J 4*^ ---'ViJ --j; . :3.t," *?; r,__; ' - .. :-: ** * P- - _ ;v'-'" .V. " 1 ^'-V"; - :;'v ' - tab; /:> ?ro 30 (0 Co ro co . ... ;> '-i ' '3 .>4 -: -.. v..-i 14--T< VtiL 64, IM7 fhttM thr II dtk KtOK, ud detf. tnliKlwIii. cittf, tW ntt. jntM vu PMumavt inu ihuw>< MUhdm. InHhy pmmiwi, irhiWhimii iht staff ol curing plants, 7f of the mmpy ptnnm (t pun. met** to tiw tortbod* Uitffmvt Inti ib(d that oom of Ibr pn*. ftottiooi wtt Mmd with staff employed 2-5 yemn in tbo prints. In three um the proteioofimrai mew modified* the w- gWrelln Inctioa brine higher and the v-globulin Inciim bchi lover then in the prennf Hh neg. reactions to the fep* etet of O in the urine. It eis concluded that the cipebty of the ofpuea to mctaboltoc tl docrenaed ilttr 2 rein. M. Ben Elkscf Bffact of hmdhw p-xytone lattrtoa the oxidetie# ylntlto of tot Uver mitochondria. Hsia-Ytog Chen* Md Chen To Yuen (SMoviet Friendship Hoap., Peking, Chinn). Sriwf Wm Ho* Hath Ym SM*t It'n W* Li Htmtk />* 6(3)t 923~6(lM6)(Ch). Oml administration of beudiloio*h xylene (1* 0J6 i./kx./dey) to mu uncoupled the oxidetive phoa- pborylattoa of the liver mitochondria, in extent proportional to the durntion of I treatment. The dccroise in the production of ATP with insufiiaat energy supply of tissue mey be the basis of the toxic reunion of I such ns generalised weakness, fatigue, dhtotot hendnebe. BHJJ 13414 Adteneihto toartivattou capacity of the normal and of thn CCli priaouad liver pari--d in vitro. Bmmi Cottiner, L. Vnmlifi nnd Vkm Chivu (Acnd. Rep. Snc., Romania, Bu- chnraet). Stwddi Cmdfh FMfnwoi. 17(4), 335-7( 1P66)<Rom). Wnrmol tut liven, nnd liven originating from CCVtreated rat* were perfused with ndiennline in vitro. The litter showed n lowtntoof ndieunlimt dexrndntiou ns competed with the former. 8TJQ 13430 Pyinik add must in aento baibtamto poisonh|. B. P. Uuiaihov (S. 14. Kirov Mil. Med. Acad.* Leningrad). Twt AM. 33(10), l(O-4flfi60KRuss). in deep corns due to bubfenrat* htnticitiot* U ms. % pyruvic arid (1) wns found to the blood. Its omen, decreased with recovery to 0.77 ms. %. Whcm the t otos. itochcd l.B-2 mx. %, computations occurred and the nsparotfcn was disturbed. The 1 cona. was directly iwopsetifitoi to the sssuitf of mtoiirotiow, ns observed to n totnl of 33 primed bn--s, Miloitov Kslsb INK laMUte tl tosoynthoato of pratoto nnd nucleic nd4 by phtoiflr fpmfia to vivo. G. V, Kukushkina, L. B. Gor- Nmivs* omd N. M. Emnnuel (Inst. Chem. Phys.v Moscow). V*pr. MM. Atom. 12(A), 453-6(t066)<Rure). Mke with the BWidi ernes msdsssu or solid bcpntomn XXII were injected ohltnid.dwtomiy *C4abtkd L*mtooaesds (1) (Id pc./ tototoh No formt*-C (Q) (5 pc.) or sdcaane-#.C (HI) (17 tt). After B toto** owe croup wns mjccted iotrapcfitowcmlly with Pr toftote (IV) to 0.pi XaQ sod soother, with 4-mcthyh t| dl tot Mrtylplu owl (V) to 2% *. Tns IP. Controls were Ascitic fluid sample* were token i nt timr intervals from 0 to ICO I with n 5:4:1 mm. of 0.9% NaCl. 03if NuHPQi*sd02if KBiPOi. Mirewith solid tumor* were notoosd oftto IB mto* and the utimws, liver, kidneys, nod pins sue removed and toontmto. When 1 wns used, the mb were treated with cold 6% CUCCOOH nnd the pptd. pro- totos isototed nnd csnnd. When 0 and 111 were used. 5% Cl#- COOOH wushtoc* wen end. with EtOk the no. layer evnpd., and the reridwe (acid-sol. fraction) cured. for radkmctivtty. The sto'bwl fracture wns washed with cold 96% EtOH and touted few 10 mto* at 50* with EtOH-EtiO (2.1) to remove lipids. A sample wns cured- low radkrertivtty nnd the rest eetd. with 10% XaQ <pH 7.4-74) for 30 min. nt 95*. Nucleic acids were add. by nddtoc 9 to*, of told Id1,, EtOH and washed with 70% BtOH. la mke with ascites tumors, injecttoo of 75 me./ kg- of V dcotwsod 1 intwymtoM into protein by 30% s eon* pared with the auuuis; B0 rnc./kg. <4 V inhibited 1 imepun* tits almost eompktely. Injecttoo of 100 me. of V/kg. de creased m totofpmntiuo into .metric acids by Br;; Jilt me. of V/k|> tohibeted IQ inwptolin almcwt completely, injec tion of 30 mg. of IV/kg. or of 1JO mg. of V/kg. after 150 min. de creased O ineurporattoa into add-instd. fraction by 45-65%. toto rariek arid by M-dl*,;, toto and-vol. fraction by sad totoproteins, by 30-44*;. In mice with solid hepatoma, in jection of 150 mg. ui IV/kg. after 150 min. decreased I incorpora tion into tumor proteins by 26%; 200 my. of IV/kg. deermaed I Incorporation by 1X1%. Injection of 150-200 mg.Ag. of IV had no effect on protein biosynthesis in kidneys and the liver of normal mice nod to kidneys of tumor-bearing mice whieh showed some activation of I hrawnliun in the liver. Injection uf 200 mg* of IVAx- decreased I incorporation into spieim proteins of normal and tumor-bearing mke by 30%; 150 tng.Ax. had no effect on protein biosynthesis in the spleen. Fvlis Borrk 13444 Ixpartmaatal Intoxication by ammoaium salts. Fro- toctionny soma amino acids and thsk mechanism of action. F. Cimino and K. Salvatore (Univ. Naples). Bwhtm. Appi. 19 (2), 67-35(1966Kltal). The biochem. conversion of Nlft into urea is dkeussed relative to the protection afforded in acute and chronic NH mtoxicatton by some compds. assued, with the coo- wjo* pcoccm. Ptptl., acute Vila pto* rati by admaktinsf L-D NHAk. pnenfad by varying doses of protective amtua acid* and their rents. Bsied on mortality sod cnuvnlsmn, irtuusr (K) prwvidrs the most rffec- tivr priHretioo at as tow a dtsr a* 0.1 millinoWAl- A nwxt. (A) L^rnithtne and t-aspariic and at a dine of 1.0 millinud*/ kg. protect* as effectively as I. A emupamon of bk*id Nila and urea levels using i and A shows 1 to be mote effective a ptw tcciur than A. In rats iotoikatcd with a L.D.*of NHOAcand protected by A, wmethylaspartk acid injected intraperitancally in a dose of 3.4 millimolrs/kg. produors appro*. 64% mortality and 90% convulsions. Utilising this same procedure but sub- stituting I for A, the mortality and convulsions percentages de^ crease. Further, a dose of 0.5 millimole IAg- produces 3.3% mortality and 20% convulsions, while a dose of 1.0 millimole IAg. produces 21% mortality and 38% convulsions. 67 refer ences. Domenic A. Yavala 1345k Erythrocytic ALA dahydratass and load. D. Bonsig- nore, P. Galismoo, and C. Canasegna (Univ. Genoa). Pan* rettorsn MM. (Eagl. Ed.) 8(7-3). 232-4(lP66)(nf). Persons having l*b poisoning showed an increased urinary excretion of aminoievulmic add (ALA) (I), wbkh was assoed. with a sig nificantly deercuaed activity of I dehydratase to the erythrocytes. The assay of I dehydratase may be of significance in assessing the gravity of Pb pownisc, since in cxpli. animals the level of I dehydratase was related to the extent of the poisoning- B. 5. 5. R- Rao I244j Relations botwooa tbo porphyria metaboUrea and tbo nicotinic acid metabolism in sotumino poisonmg. L- Pccorm, A. Silvestrom, and A. Brancaccin Naples). FoaoMarrm MM. (Engl. Ed.) 8(7-8), 2fM-KU9b6)(En#). Pohoning of rab bits with PbfOAch decreased nicotinic add (I) by 75% to the blood and unne and markedly marased erytlirocyte-frce proto porphyria (II) (13-247 y %) and urinary coproporphyria (UI) (14-341 t/24 bis.), aminolevultoic acid (IV) (U.2-21 mg./l.), porphobilinogen (V) (trace-6,6 mg./l-)* and xanthurenic acid (VI)(l.(iKlH.3mg.A4hrx.). I administration either concurrently with or 15 days after Pb poisoning increased akutinemto and okotinuna and markedly inhibited (by 50-30%) the effects of Pb poisoning on II, UI, IV, V, and VI. The effects of Pb pobon- tog are probably mediated through inhibition of pyridine corn- xyme synthesis directly or indirectly through vitamin B inbibi- lion. HFJN 1247k Porphyrin to towaethyl load potooutof. M. Crcpet and P. Chkxura (Univ. Padua, Italy), ffseiniarrra MM, (Kngl. Ed.) 8(7-3). 295-301(1966XEng). The Icveto of ainmolevuliiiic add, Pb, and porphyrins were detd. to blood and unne samples of persons having Pb poisoning due to iaorg. Pb salts or Pb tetraethyl and also to cxptl. animals with expti. Pb poisoning. to patterning due to Pb tetraethyl caused a significant inmeaae to the lewH of free protoporphyrin in erythrocytes, while Pb poi soning due to inorg. Pb salt* caused an tncvmsod urinary exrae- tton of aminolevulinic acid and coproporphyrin. B. S. S. R. Rao I34ttm Bt Injury to rat and monkey Livor. Donald }. Sv<boda. Harold Grady, ami John Higgiwon (Univ. of Kan sas, Med. Center, Kansas City). *4mcr. J. faihot. 49(6), 10J3- 51(1^64)1 Eng). Oral administration of pure aftatosto B, (0.45- 3.76 mg.Ag.) or tocrapcritoocal injcctren of a 0.167-mg.Ag. dose into rats produced periportal parenchymal cell nccrusn and slight bile duct proliferation, together with *epn. of the granular mod fibrillar components of the nucleolus with the formation of nucleolar cup*. The alterations in fine structure were also found to monkeys after oral administration of (M5 tug- purified alia* tosto Bi/kg. or intlspcntonol injection of a 2.5-mg./kf dose. The livers of rats receiving an oral 0.4^mg./kg. dose 24-72 hra. before saoifice showed decreased levels of RXA and protein in both the nucleus and cytoplasm. The RNA-ti^DNA ratio in a total liver homogenate decreased by 40%, and that to a mclfsr fraction by 8V,: the protein-l^DNA ratio in the total homoge nate decreased by 24%. P.0 ratios showed decreasing values with increasing functional damage to the hepatic mitochondria after administration of ifiatosin Bt. Both 0 cunvumption and phosphorylation were inhibited, although the essentially normal O consumptMu 72 hr*, after administration of the toxin may have indicated rveovtfy of respiration without the concomitant return to normal phcwphorylatifin levels. The acute hepatic lesions shown by light microscopy of liver front treated monkeys re sembled the dtanges in human liver during acute viral hepatitis. Administration of pure allatoxto Bi (1 ppin. of a synthetic diet fed ad libitum to rats for 1 weeks) did not produce the nuclear, nudeolar, and cytoplosnik alterations found after the aeute administration, although wril-differentuted hcpstocvlluUr carci noma* appeared in rats whose livers otherwise showed little ab normality. 53 reference*. BPJN 1344a Dlatiibutton and excretion of cyctomat'k4C aodiua to HtlMll. Jonathan P. Miller* L. E. Michael Crawford, Kiibvrt C. Sondrrs, and Earl V. Cardinal (Dept, of Hiarmacitl., Abbott Labs., North Chicago). Buxkrm. Bwpkvi, Rn. Ctov, 25(2), 153-7( I960)< Eng). Na cyclamatc-MC dutnbutton, exerrttun. r`- * k, j 7T W---~ r-, . V*'. Q ;, v.r! .. rSa'an ; i $ i .1 >? 1^;i 'A i Emm '*;IvX` "vV- v-" &,.*' Y, . Yy-YY'-Y -yY . " :\V~. '' :'-.-T *1- "'3; i-:?Vl': ' . CrY "7 ~ > *` w t," , - -V 'j- v? ; YY:? "fY YY.YI-.V'Y' YY --' :/ Y-.-. A/ . _ v*sr ;Y Y-ir-'-iv' "; 'V-: ..---Y-v-'YY -- -"Y' -- ...Y , ; y '-. C , ' ai Y T* *:y ":' ' -'- * ,. - -f -yi vc*. >f.f.>. e# /. rtymrf FAm#-*f 1968, *'r*K *r> 16 JpJnf Uu' /mk/jl , l.ewmrvaif. 1`SSfil KaeasikW. Tthitkd. {KbcI. A rt d ttfflk ha* !ht it* by tona, VH 6 Ru** Ht.l>*thyWwe <70W*.' kwh Ik* imuWmi l KHM nmn wt Kllwwtt kv i u to rat* *ad toww iwnunl the hepatic the fsafiial fCt i i of (hr O bmrtl ui iu tfr*lna t^inai. gdivmiw uUtf tml hisfanonase sct/ritei, dorreasaftr the Far Ik tmarn tnyriiy o*d gas mist., US <h 5'. Cth, tyraitimr end hoinnJ** WsrH m the bbiod and organs of the (hr EvOH rwriKx o ibdiiliy Urtf. and peo;*iCi*wi ittmal* I he ilisiurbanres vbwrvvd ift maw t* (hr rw. of EtOH (hr (tfrlcwlr. Hvtfvrv. l (d Htr *ni1 r^t* with *rutr {vayrtliyfene judyamiar pmwning may be cyniw *( rmtd with iff, 0* *e AS CO 77',' > . Uw [|nr i.i i:>e ii rrnwil ohvl*dve deammatvin of endogenous amines muifflMM <4 hlOH ifii MiHilir (> thrl itmind mi 'hr tnii with the naiwviurut hamatam of al<leh>do. Niff, and Hi<l, rat. Thr prrtttmr conn, of MrCO, HOAr, (ivmt# hvl, *M Bi JR tortit and cm wtiarrd m all npli. Whrc KiOll tt om- SOMw Effect of olarin on phagacytoai* ift <break tnaitro* ww) AC (hor two different rttn. uktww M the Jactr hltffit noiaoftiag. rn)#-tn*ku, K L.; Chukichev, K. M.; pfmw ni tad Mcuir Irvnt <4 the perfusate vm no(l Mal'uiri.kif, A. ,\l. f I'cent, ('me., Fefin, I'SSK). FurniW. id both I7l*t ol rvpu, llocntf. lb* ulilarUM of lu<fw 1668, 3K3>. 'Russ'. Trmitrotohtcne (TNT) by noUlrd pfrfsted liver lohibitrd, Add rrrioor level* in- aibmmvtrml orally at 3(1 mg..kg d^dy for 0 days to rata t*n> cmard QiArhrdlT. when KtOlf wunmiuflMd at ibownully nH ^ressively drerraseil phi(irp<nii. Niann administered simuU ntn, ftJthouih no effect ruMtAl ta the ptduuir Wvrl\<4 (hrv lotw^iudy at 1 mg. kc. *.c. prevented this dtcreatg and even m mctiM'tn *bn KtOH was caniunnl #1 norm*! run. ,'7 eicu^l the plufeitwviif activity of the leukocytes to |.6-times(he rdmiMi, KCVL levi I in cimtrul rat*. 1 BJJR SWIft Actio* of Wrytliom btc oft primary nlwm of swine 505W* Pathogenic effect of chroaic arpoasra to vinyl chloride *sfla. Vetm Talluri, Mans; Ouiggam, Vivian* Sinu, on rabbit*. Valin, A. X.; I'Uikhnva, K. |. <|nst. Gig. Tr. l*rof Svaa, Italy). Caryofagm 1907. 2ib4), 365-07 (Enel. The rj|*4,, (Hirki, I'SSR). Fatmnkoi. Tttkttkai. 1968, 31(3). 3W- effect of fir** poisoning on mitosis and roocpliofovy of *we 7j (Hu**). Jn rabbit* ripani Pi vinyl chloride (9-10 ntg./l. kslnrf evil ind lymphocyte cultures was Kwlml. Treatment *Kl Utr 4 hrs. daily (* 5.6 months altered d-wmve* (frequency with Be*4 had a hamful effect on All the mitotic phase* and >H0 11/.) apprarn] on the rlpclrueacTphafograiti from the an* abaoraolfty of duMBMomn ii frequent, Ac liuh rwwnt. fr/Htr hv|v*tlulanuc nuclei, and the pn<nrti.ili of the anterior the Action of Be** was less pronounced on kidney cells than on and ptisirrmr nuclei mcti .tsrd by IX -30 and 70*WrJ, reap., over lymphocytes. Be4* eaerti its toxic actum by oinipeiitwm onitrnl values. Concntnit.int chance* in the cardmv asciiUr tye with Me** either in the activation of tlN'A polymer*** or m ii m (bradyc.infM, arrlivtlmua, dittravd voltage of the to< the binding of DN'A to histones. L. Mironc dutdiMl iltMriK-TirdHiL'ram pc-^ks nr whole complete*, decreased 80992q Protactie* effect of ethyl alcohol towards tllyl sico- `Ui(vtnm <( %yHt<ile, mcrea^d arterial presnm. and teUhlni boMadneed hepatic leaiaaa, Schwartmann, V., Infante, K.; 1 (!,-! il.)\v i .dxi ipmtrrrd. The functional change* tn the an- kaisonmer. A.; Caeoli. J. (CHI' Samt-Antoine, l'arit. Ff.. Urrmr -ml intrrnr hyivithalamic nuclei may have a rule in the C. R. .Vac. fisef. 1067, 101(12). 2426 p tfr), A t*>.nim. per .if toxic aiieujncumxis due to vinyl chloride. fusion of notated rat liver with blood come, allyl ale. nt.oiA ml.' BJJR 1M mi.) caused a release of lactic dehydrogenase, male !chy. S0600r Brown FK- III. Admiaiatrstioa of high doft* 16 dfOfesMie. and glutamic-pyruvic transaminase into (he ( rfuwir rtand mice (7r.f-. I*.; Gaunt. I. K.; Itall, 1>. Colbert, and a simultaneous depletion of tliese rniytticx from the liver; L,; lldi\touot I'.li/abcth (lint. Iml, Bml Re*. Assoc., Car*hal- ale. dehydrocenase and chitamic dehydrogenase activities ton, l-.niil.). 'fwd. Tinud, 1968, *K1), 1-11 (Rug), were oot detected in the perfusate and were not deem*serf m the Acute oral luicity *tudie with Rmwn KK gave LUm values >2 liver. Biliary secretion was irreversibly arrested afirr lh-jo x. kr. and H g. kx. in mice and rats, wp. The values for i.p, nun, of ptdsMon, and hepatie Inwos occurred, A jvmifi, |m. injection were 1.3 Jx-'kg.m mice and ( 75*1.16 g. kc-mbits. fusmn with blood contg. htOif Pruir to the treatment ith all>l VVhen frprateil daily oral dom ranging from (1.1 to 2 g. kg. Were ak. prevented the enayme release, the hepatic lest ns and the wv*rn tn mts, a |frerpit**n wt. In** and a varuoUr myopathy effect on biliary secretion, and dul not cau* the ii*irfiv r*f ale. .f (hr heart and xkclrt^l mu<wlr* accompanied by bpufuKm dehydrngenav or glutamic dehydrogenase activities. 1(1'.IK fitrm.iHi0 mvurTtt! with diw <>f (.6 g kg, and over. At the 5<S9Jr Effect of ethanol on hepatic metabolism and entente liufu-t i|tw fm|>ioyi '2 g k*. >, there was also hepatic rvntfi* ACtiriti**. Nelsoo, Katricta Ann tIndiana I'niv,, l(l*hmiiig- l*lrtjJ,ir and rraI tulmUr dtgeneralion Kfeireattomt too. Indiana), 1967, l<4 pp. tKng). Avail- I'ntv. Mierntilms, with .titi)i*itic* tnlunil tlu wt^idrncr of muvlr lesions. Re* Aon Arbor, Mich., Order No. d^722K. From l>w. Anir. H (valid i.p. injection did nu| havesuy effect on the heart or skeletal 1999, 2fU). 4flm. SM>C niuvlr. Only 2 ul (he 0 cumponenfs of fJnoro FK, .ddumiivr 50594a Esfxy*liAked calcium tnUMport in liver mitochoodna 5-i p-ulfuphen>la/o .toluene tit *nd I2f-durata<w4-tp-ul(w> dmi&t carbon tetrachloride iatoaicataon. Carafoh. KmcMn; ph iivUio Iwn/enr dl*, |rmluced muscle damage after repealed Tiouot Roberta (L'niv. Modena, Modena, lu/y). Eip>. oral doe* of ii 5 g. k^. Oinipwraftle dow* of mists, contg. the Patkct. 1904,90). 131-40 (Kng). In rats intoxicated by the i-jv other i'*mj,*mruix a* writ j> 1 or 11 were considerably leu toxic, tnc mtubatiou of <1,3 ml. CCU 20ft g,, Co1* esmen. m hvw mito- 'After dadv ora) iltiw* of 1 g. kg., nwcle lesions were found iq cboodna increased ^10-fold within 1H>20 hrs. Koarver, i.|>. rat*, faliliito. and Kuiuea-pigs, tmt none were seen ft mice or injected *Ca was not taken up by hepatic itiituchondn.i m m- luni*tr(*- Hie niulu *uxceq that the mtrstmaJ tmenllora if toaieated rats as rapidly as in normal animals. In vitro, lu-p.-tu- n ^Htn^ililr for the breakdown of the cnmpoaAtt* of Brawn t*K Ditochoodria from CCU-intoxicated fats did not slmw imriniml to to*ic !>(><luct*. \ jrution> te(wrrn species and between ani Ca** uptake, but Ca*4 release induced by uxkUlivr phrph.r> U- mal* of Ihi *.inir *|H<ie* may lie due to qual. and quant, dif- lion unooupievs was greatly decreased. Tips sug/estrd tlui m lifimv'm the mtest-na! miiroliMl population. RC-V1* CCU mtoincstKKi, the balance between Al>K phosphorylati'm and Ca14 uptake is shifted m favor of the latter, thus cnntrthut* nt to the accumulation of Ca1* m mitochondria. UltJS S0S95t Protftcbra effecta of alpha-tocopherol no the hepato- tntklty of carbon tatrachloridc: an tltctma microscope study. MeMolesi, TmcopoUnst. Pharmacol,, t`mv. Milan. Milan, 1 t>*ly J. Exp* ,!/f. ratkei. 1968, tf(l), 141-7 (Bng). The oral adimm^ra. tionof 2.5ml. kg. CC1.dihl. 1. 2 w uh Ik> . pamtbn to rat > i*T'^lur^l severe hepatic lesions within 24 hrs. However, hvrr daniagi' as markedly reduced m rats i.p. mpvted with the hint ants>sil.mt( SObOls Brown FK IV. Cytopathlc effecta of Brown FX on cardiac and skeletal nmacle is the tat. T.; Mutr* A.; ('.oMierg^L,; !iat*tonr, Khialirth tfJrd. fnd. find. Res, Asaue., Ciirshalioti, Luiil.i. F<*nd <`otmet. Toueot. 1968, 0(1), 13-24 il'ng). Adm<rn%rration of 2 or 3 masxivetl x. kg.) oral doses of Rrown FK to rat\ mduci'd a myopathy in cardiac and skeletal rnu^lo ch.ir4(ien/(l fy multiple v.icimlrs *^1-2 a in dtam. VitU'tnjtlmjlly, !hv convxted of areas of fibrdloiyxt*, af* fiTiittc ontulty the A-b.md. Histfichetn., the myopathy was acoiNitMiind Uy a miHlerate increase in acid phosphatase activity aHwephcrd MKOiutr /125 mg. kg.), before CCU ailmiui^iri* and b* a Uo of ph<fphory(a<te activity. Sub*equetttfy, etuitpkte (on. This suggested that hptJ perosidn. is the primary mvha- ly<.:% n( tlu- .illn'nl filers ensued. In the heart, fysts was fol- fttsm of CCU hepstotoxicity. 27 references. IHlJN low-d iiy n-uroph.iKC mvasum and fibroblastic prulderatmn, 50896ti Diatributkm and toxicity of aliphatic hydrocarbons in and in skeUtal rnun'lr. by regeneration. The igqinigiKt of body batftfta. Shugaev, B. B. iVan^Uv. Mnl. lim., V.tntdavl. li|fc.{iw m m muscle filler* and in marmiduge* wg* scanty and USSR). Frm*koL Tokukoi. 1968, 3K3), 31 3 <Ku'M. (Va* *rr me. When Hfown FK was given in tlu* diet at a level of 2*`c, dinifttatog. was used to study the di^tnlmtinn of tl vnUtiir hy. i> i It'd* *i* and .m increase m the no. and electron d. of Ijrw^ dnxarbons in the mouse and rat body tissues. The v*.(jiilc iMim was ohsreved uU/asttuctutaUy ilurmg week 2*3 of the hydrocarbon conimt of (he brum and parrfichymat-nii organs list The'*- i!uifc'n were accompanied by a marked elevation was similar, but the level m the fatty titiue was signifuantly of hut.wl.cnt. deiiuinsirahh Arid phosphatase. I*nigresstve higher than in the bram, liver, kidney*. <r spleen. I hrf*- wa* a tlr|.rtiiMni of lipiiuxm was the principal |Nithlogical feature parallel between the ttikimty and effective nfrbril rrmen *.4 iwf ilunrtif s 3 In iu) fUrnagr to (he A- and Mu'idt tit both prrnr. divinyl, and laolaitylene, but M of butam, 2-methv {|wnt- ranfi.tr *nd skiUtal ntuwle distmcuidir* the llvown FK mytip- lasr, of 2-meihylprai'l'enr. The do mvl convu. *o hi tu v in atfiy from tfi.it known to lir t>roduc(-d tty high dines of corti- the medulla obtongata than in the cerebellum or cerehi*! 4*.rtps. oHiruxlv th\(otMu, .'(ilotiapunr, ot pfasitwicwf. ft'Mit ughemic HJJK tatn-igr .md If'iM tMuwle dainigr resulting from deprtvalum of 50597V Soma biochemical change* fit aviataia following scuta K, Ca, * Mt 1 hr l>Hungrt and acruniuiatwn of pafyathylaftr ptdyaa^oa poisoniflg sAfimdiaya, i*. A ^wuth * lifVituHin are *ugg-stise of ixiuiary lyvowmtal damage which ':w .. i Y-;', ' * \ - *' "7 ` * . * , ^ i, . - Svi] Z ??J5 J3 So 0) 03 otroo t `71: -Ci;. ->1 '-.ir,;. " "v >* - --V-S' Mum m iiw^wi a>tfii WiVi iit-.ti-.rm&itim 7&: Ji ^ci^Li T WgfcW''' - B*T!Ji ;?. :;- t-N vV-':^ ;. - .'r^ -u? CO 'S -`t I Ilf J4--TtafcoJocy Vot. 70, 1969 !&t4M 9m in Ik fatty Kid coapt, of (k Mo between HCN* ttald! and untreated nti, N. CmiIroiui. IlMUa Ctnttva of Urei daaag* civicd by hrilrtdln with ailjBiik to t modal of ontibepatotoxia tknpy. Vogel. Gacathcr; Temme, Inft (Biol, last. Madaa*. Cofi*ftr, Car.)* Araarrei.-FerscA, 1069* 19(4), 615-15 (Car). Silymann, the aatihepatotoxic mdi in the seeds of ^>kai m^nm, pKmicd Ik tout effects of pbaUoidin in mice, Silymann tru also effective m rrnnini the tonic effects of pbaUoidtn to mice intoxicated first with tbit compd. and then treated with tily- maria. Tbe satipbaJloMlin effect of silymarin depended oo the time interval between iatoxkmtioo and treatment* and oe the decree of liver damage. SQJG )U4Slp Btldoaco for th* bfeaettretto* of eUfremlBe. Aont, Stevca D. (Michigan State Univ., East Lansing, Mich.). Bub km. fikmrmmai. 1940. If(4). 929-32 (Each Mas. salivary activity in peotobarbitalmncstbetitcd cats occurred --1 hr. after i.v. administration of sla/ramine (04 mg./kg); tbe dura- tioa of ealivatMa wme extremely long, usually lasting for 6 hrs- after a single dam. la addn. to mfivation, moot of the exocrine glands were specifically stimulated by tlaffamine. Upon ad* atniMniioe of ikfraitiiae to cows, sheep, and fail with pan* creatic caanules there was also a substantial delay before an in* cream in pancreatic flow was observed. In mice, a longer delay omrred after i.v. injection of S rog./kg, than with i.p, adminis tration at tbe tame dose; this delay was feemad by injection dirretfy into tbe portal vein. Delay of the effect of the drug at 4 mg./kg. was significantly extended by briefly isolating (with damps) the liver of retsr tbe effect eras completely eliminated by the permanent isolation of the liver. Common inducers of bvtr dnuMnetaboiixing eaxymrs consistently reduced the delay in the induction of salivation in rake, while inhibitors of the en cysts oonnstcncly lengthened the delay. Thus, slalraimne seems to require activation by the liver before stimulating no crine glands, Tbe enzyme* involved in this *cttv*tioo are probably cheat responsible for the metabolism of most xeno- Mirtin BYJN UMSdq Nrnklim of yhorphotipfd* in the brain and Brer ad itb daring htebatbe with organephoeahoroa compounds. Dvorkre, v7Vu.; "Tnf'i*lo, A` . .P......(.P...a..v..l.o...v....Inst. ~Physio.l., .Le.nto* mud, USER). BymU.EMtp, Bud, XM, 1049,0713). SO 2 (Russ). OtfunnliiiRihnin* compd*. LG-63 (& mg./kg.) ond GA-rtl (0.4 mc-/kg*) administered im. to rats did not affect the level of pfiiwphnfipids in the brum ond liver or the rate of restoration of pbuephnbpids to the brain. The metabolism of phospholipids an the liver was increased 244*7 by organopbosphorus compd. 104} and 32.4*7 by OA41. Tbe increased intensity of phos pholipid metiholf may be connected in some way to increased activity of the hepatic ceils during fetwatm of the eholre- esterase inhibitor*. BJ JR 1U45V Toxicity atadleo In mteo treated with l^setsws- fnuifllilbibe (ara-C). Lcoch. William B.: Laater, W. Purnell, Jr,; Mayo* Joseph G.; Griswold, Daniel P., Jr.; Sehabri, Frank M. Jr. (Med. Center, Univ. of AUbnma, Birmingham, Ala.). Umar Art. 1949. 20(3). 52*4$ (Bug). Optimam therapeutic dosage schedules of l4reAbisofunflo yfcytaeinc (ara-C) admuktstered i.p. in mice (15 mg./kg.. every 1 bn. for 24 bra.) result in ka/yurihcctic damage to the aypt epithelial crlla of the intestinal mucosa. This damage is most severe at 4 hr*, (earliest observations made) after tbe end of the 24-hr. sourer, after which there is a rapid recovery to completion in 73 hr*. The damage is thus txanutury and resemble* that of hydroxyurea. This cycle of transitory intestinal damage fol lowed by iscuvtry ocean after each therapeutic- dotage schedule Of ara-C as loot as the schedule is not repeated more often than tvary 4th day. Progressive damage to the racestiaai nucow aeesmpamed by change* in tbe hematopoietic tissue* occurs only if this optimum therapeutic dose (15 mg./kg., every 3 bn.) Is ooucumed uninterrupted to the LDm dear (360 mg./ kg* to 72 bn.) and beyond. Irreversible change* are seen m the in- toainal nwna* and a progressive depopulation of the booc nunuv with alternate apfawa ensue*as the LDw fur > reached and sarpuased. RCTT ll|44a Effect af ktyUud bydreiytefucua (BBT) oo ret Brer rytorbramr aridsso activity. Pascal, Gerard; Tevromc, Tberene (Centre Recti. Nutr., C.N-K-S.. Bellevue, Fr.). C. A. Acad. Sti.. Parer. Nre. 0 1949,SffKflt ), 152*41 (Fr). The oral administration of BUT (0.057 io the food, a coneu. 50-fokl trettr than that anthmited for human food) Iv 1 week*corned a 13^22.(7 decrease in bepauc cytochrome oxidase activity la vat* of both win. The addn. of BIIT to rat liver homoge- uatco ot the level of 10 n./|. liver caused o I3r7 decrease in cytorbrumn oxidase activity. Tims. BUT appear* to exert aa antioxidant effect on in vivo metabolism. DFJF KU457t Activity af taeniae dreminane in ret kidney, liver, tad bleed during oxpenmeafal ureayl nitrate Intoxication, Baatjdc, Janinc; Dastide, Pierre (Fac. Mixte Med. IMiarm., Clermeat-Pcrread, Fr.). C. A. 3c. B(W. 1905, 162(5-4), 1106-71 (Fr). Guoniae deaminase activity (1) was studied in the liver, kidney, and blood of rets during exptl. intoxicatiou with nrenyf nitrate (1 mt/i.p- of a sofn. contg. 2 g,/l. p*r 100 g. body wt.), A* early as 24 hr*, later a progressive elevation f 1 was noted in all m *#, Imt there wa* a definite lowering of ( in the kidney for the first 12 hr*, after the start of intMicstmo. Dofothy J. Buehanan-Davidsoo IlMStu Escretieo oftetreethylgetmaniuin in the ret. Ous* trm. }.; Clavri. M. J.; Pitel. G. (Centre Kech. Toxictes, C.N.KdS., Toulouse, Fr.). C. R. S. Bud. 1905, 162(5-6), 1220-9 (Fr): cf. G. Pitet (1967). EuGe (I). a very rewstaat compd. in vitro, is degraded very rasdy in the ret. Although 1 has a very high b p., it is eliminated in large amts* during respire* tioo. The metabolite* of 1 found in rat urine are GeO* or the germanates. The metaboliwn of 1 is different from that of tetra ethyllead (II) or tctraethyltin (IQ). No evidence wa* found for the formation of trirthy(germanium, which explains the weak toxicity of 1 compared to XI and III. Dorothy J. Buchanan-Davidson 1I54S9V ff-frydrexybatyrrte dahydrogonx*# activity of rat kidney homogenate fraction* after experimental ureayl nitres* intoxication, Basttde, Janinc; Bastide, Pierre (Foe. Mixte Med. Pharm., Ocrmont-Fenund, Fr.). C. R. Smc. Bid, 1945, 162(6-9), 1492-3 (Fr). Most of the ohydrutybutyretc de hydrogenase activity of the rat kidney i* found io the reper- oataot after centn/ugatmu at 24,(00 g for 2 hr*. This activity demented with tune during exptl. uraayl nitrate poisoning, whereas the contents of protein, ONA, and RNA were relatively low and underwent but little variation. C. W. Aekereoo IM440p Effect of ethyl bromide on tho Uvor. Kanmullinn, N'. K-: Gixatullma, A, A. (L'fitn- Nucb.-iuM. lost. Gig. ProfxaboU Vf*. UBSK), Formed, rrinfiof. (.Vfetcew) 1949, 32<2), 165-7 (Russ). EtBr lumes (3.4 mg..1.) inhaled by rets and rabbits fir 4 hr*, daily for 0 months disrupted the func tional ability of the liver, decreased the hepatic glycogen and fat levels, and prolonged hexenal sleep. Granular dystrophy in the hepatic cells and a decreased KN'A level in the cytoplasm were detected. BJJR 11M6IQ Hsmopoierix in chronic babatrine prireoing of Vlstar rets. Levin, G. S.; Xovachrnko, Z. 1. (Cxb. Nauch.- Issied. Inst. Gcmatol. Pefeliv. Krovi, USSR). Frnrmmkil* TokttMtd. (Xfstrew) 1949, 32(2). 170-1 (Kuo*). Ifdaocrmc admutixtered u. at 3-10 mg./100 g, once a week for 1-6 mouths to Wixtar rets caused hepatic lesions, hypochromic aaemm* MvercretkmlueytoHS,o<irmoblastoss,andleukoprAio. Brythro- bUMC xprvut hyperplasia* an increased no. of mitoses* gad an increased do. of reticular and esp. pUimatie cells were observed. The observed change* m the Mood and bone marrow suggest development of an autoimmune form of hemolytic anemia ia response to chronic hebotrine poisKMimg. BJJK UJ462r Bonsano metabolism in the brer of xparimental and man. Tiunov, L. A.; Sokolova. T. 1.; Baadmaa, A. L. (USSR), fermakri. TokjikW. {Mtuew) 1949, 33(2), 165-6 (Ross). Tbe rate of CD# metabolism dunng 24 bn. of incubation was similar m Ibex homogenate* from bamaos and ratt, mure rapid in homogenate* from guinea pigs, and slower in rabbit fiver homogenate*. Speeiewspceific differences >teared to be revolved ut CH conversum, since tbe activities o( aryfi4* hydroxylase and glucuniayltraniJevmse inrreared white the sollanatiog system activity did not change an CHrVrvattd reta. In C*)1eUcitd rebbitx the Milfatc adenyltranderase and aryl suffocranifcrase activities decreoacd dunng diwupcioa of the sulfmutmc syttriu. The hiRh rate of Clli eonvemon is guinea pig* may be connected with the relatively high liver entaiaao activity. BJJR 113443a Effect of the sodium salt of ideooriao triybosphsta on experimental eyxtud* poiocoing of reta (mochaaiam of tho anodota) actios Mooketi, K. V.: Gaoxhare. P. S. (Odes*. Med. Inst., Odrnaa. USSR). FmtrnmM. Tokitkd. (Moscow) 1949. 33(3). 214-15 (Ra*s). Na ATP (0.5 ml. of a t% aria.) given t.c. or i.m. to reu 1 hr. prior to administration of the mta. lethal door of N*CS` prolonged survival. When given ax. im mediately after lethal cyanide poisoning it substantially extended the life spaa of 50' / and prevented ileath re the other 69% of the rets. The antidotie effect of ATP may remit from it* ability to restore respiration by bypassing cyisidHtniitivc enxyitm. BtCJR r* 1134641 Changea la tho cardiac activity of rat* chronically sxpoMil to vioyl chlorfito vapor*. Vasre, A. N.; Plokhova, K. I. (Go*`k. Nauch.-lssled. lost. Gig. Tr. Pref. Zobol., Gooki, USSR). Farmtkois TckitiM. (V*uw) 1949, 32(2), 239-2 (Kuxs)- Chrnotc (5 mouth*) exposure of reta to vinyl chloride vapor* ot 0.03-0-04 mg./l. disrupted cardiac work rhythm, in duced bradycardia and arrhythmia, and -educed the relative duration of l-ll and T-Il sound interval*. The relative dura tion of tbe Q-T complex did not change significantly. Within 15 day* after termination of punoning, the ret raniixc activity rhythm returned to normal, but the duration of tbe 1-11 and T-ll sound intervals remained below the lUittal level for another 15 day*. The maximal permissible cunrx. of vinyl chloride apparently it ugmficaatly less Ilian the U.03 mg./l. level pro* vxjuily estd. BJJR B K~-' l mm *. -- J -c . / 1 ?,' V 4"s . ' ** '.if:- i.%f ' , r ES rsp- yST'Vi _ ,ym 5 .-``is miriiii Yiiftttrflrififcli nUiWntf .it. . - ;-Ar^r i ifi'rata ~ ~)i; 2^6*1Q 'T.vS'. 3ft jH2:" ".1 i `"S ^ISF ^",4 V: * w1 4 *ri II Ttefctenp VoL 71, 1969 P% potemfaf ud mak-dcpmlTc piyrhiui* vt diiwH and tit striking bitwnB then noted. It n unciud tilt 7b may bo * toxic determinant in this peythoais. The Dirit tat (Dnvfc and Andclmnn, 1907) wai used lor tbn deti. of winary * aminolevulinic acid (I) Imb in patients tm eontrot*. Rendu showed on increasingly significant riw in . knit between etntrob nnd untreated patients and patients treated with LiiCOs* U may interim with Hb tyuthcxis in a similar way to Pb. 41 references. S- M. Maxwell Mite Effects of DTPA \dlethylenotriamiBoyoauatatk add) aeroaol on hmg contamination by Uatbasom. Pasquier, Christian; Voisin, Dominique; Tbieblemom, Ptcne; Perrault, Guard; Bayard, Jtnn P. (Dir. Prot* Some Radiol., C.E.N., Footenay-atu-Roees, Pr.). Comma. *<rf. At. |Pr.]f Rapp. 1960, CEA-R-3735, 19 pp. (Pr). Avail. CEA. By use of DTPA aeroeot in the treatment of pulmonary contamination by la, iu effectiveness was detd. as a function of time. Provided that h is administered at an early stage, in the 2 hn. after expo sure, >60% can be eliminated using lower thermpeutie doses than those prescribed for other methods of administration. Its amoen. with some ensymes did not enhance the therapeutic effect of the chelator. The const, for the passage of the DTPA- La eomptax fvesn the huig to the blood is --Q.OlO/min., corre sponding to a period of 44 min. A significant nonchelatahle fraction, persisting after prolonged action of the DTPA, of the enter of 40-15% is observed. DWJF 9M17t Forrfc cyanoferrate(U): as effective antidots in thaUna pftaflng. Heydlauf, Horst (lust. StruhJenbiol,. Kerafoncbnaguaitnam, Karlsruhe, Gcr.). Eur. J. Pharmacol. 1949, 6(3), 340-4 (Eng). The influence of orally administered fum. cyenofgmtcOl J, (Prussian Blue, PB) on the distribution 0*4 tuntmU "Tl eu studied in the rat. PB lowered the rt Isnlion of "Tl by inhibition of its absorption and reabsorption from the intestinal tract- The toxicity of TltSO, was decreased by PB. FB b saggested as aa antidote in T1 poisoning. V. N. Gupu Mite Cydohaimbli Hidurad altrattrnctaial changes la Iho adrenal cartas of tho rat. Dttmieh.Cs.; Szabo. D.; Okros, I* (last. Exp. Med., Hong. Aod. Sri., Budapest, Hung.). Erprrunlia IM9, 3X6), 103-6 (Eng). Wistar rats of both sexes oihsg about iHD g. vm used. Conspicuous changes in the allias urn.tin i of the aona (aicriilata cells were observed follow- mg dscapuatiao at SO min. even after the lowest (5 mg.) dose. At low power magaifieation, compact masses of irregular shape* madam d. and Idniud outlines were seen to have accumulated bstwsea arxanelka. la espts. involving both tydoheairmde and ACTH tHsmain, the ehaagm were similar, although the cells anptararf swollen. Similar observations were made m some eelb of the mu mniam, but not in the toua glomcnilosa. The indiags snggcstrd a ccnthtton between the substance seen to iiiaiimlste among organdies and the increased cholesterol tunum of ibe adrcuol cortex. The ullnstrueiural changes were ed an impainaeat of the enxyme system. P. J. Pariiek Effect of ocomao on tho level d ketone bodice in the > of ogponmaul animals of different species, liofmhue, L. A.; Tiunov. L. A.; Kolosova, T. S. (USSR). Tom Id. r*0n*d. (1toumo) 1906. 32(4), 466-7 (Russ). Rats "d mao* exposed to 30 ng. Me*CO I. and rabbits and guinea Mt expend to 73 mg. 1. for 2 hn. showed increased levels of ifaQ, acetonemic and, and d*hydnybutync acid m their tdnod and urioe tmamiuttly after inhalation and 24 hn. later, la aB 4 ipicni the d-bydroxybutync and level increased to a pater extent thaa dad the other ketone bodies. The largest in* croaaea in the MeiCO and acrtimcctie arid levels in the blood both immediately and 24 hn. alter acute inhalation occurred in rats aad the smallest chaagcaappeared in rabbits BJJk INrif Katare of tho acute actioa exerted on tho organic*. by mpnaothsanlsthylonodiainiDO. Tikhonov-* G. P.; Sidoro*, K. K. (Inst. Ifcil.-Owi. Probl., Moscow, UbJ**). Farm**tft Toknkat. (JSssow) 1969, 32(4), 473-5 (Russ). Mt***ifianoU ctbyfencdiamme (1) injected into the stomach of rats in a max. foieralih dooe (2J g. kg. in 3)f aq. sold.) disrupted the acid* base balance m the Mood after >5 hr*., increased the pH from 7.16-745 (control) to 7.4-7.49, and increased the level of free bases. One day alter 1 injection the Ca level in the serum in* cruised, the time of blood coagulation decreased, the blood pH dropped to 7.11*744. and the amt. of free bases was below nor* mai. The level of globulins decreased and the content of ilbu* mins increased tn the blond; the level of chlorides tn the urine deoeased. 1 caused necrosis in the mucous membranes of dices* five system organs, probably through ns alk. properties. BJJK 9621a Changes la adrenaline*like substances in rabbit blood following chronic exposure to vinylchloride fum--. V*xm, A* N\; Plokhova, E. 1. (Inst. Gig. Tr. Prufzabt'l., Gorki, USSR). Cit. 77. Prof. ZaM. 1969. 13(6), 46-7 (Rum). A group of 6 chinchilla rabbits was exposed for 4 hr*, daily, (Airing 6 months, to the vapors of vinyl chloride (X) in air at tMJj- 0X13 mg /l. Samples of blood were taken from the ear veins and ^analyzed for adrenaline (tl)and adr*nhne-ltkc (12) substances. Briar* the npaun to l and also in the cuntrui group of rabbits the 11 and lla levels varied little and averaged 34 og.%. After 20 days exposure the kvel of 11 and tta rote to 6.15 af .'# after 40 day* it reached 6.6 *g.r aad it remained const, thereafter. The biopotential of the posterior hypothalamus also changed. These effects of 1 are the direct cause of hypertension. CPJ K )22r ATP aad lipid contents in tha liver of mica after in* halation of chlorinated hydrocarbons. Ovate, Maxaaa; Tomo* kuni, Katsumaro; Watanabe. Stuntaku (Med. Sch., Okayama Univ., Okayama, Japan). /W. Health (A'owaioki, Japan.) 1966. 6(3), 116-9 (Ong). The hepatic ATP level decrease and the onset of fatty liver as indicated by the increase in the amt. of the total lipids and triglycerides ia the mice exposed to 3 kiads of chlorinated hydrocarbons ant in the following order: CCU, tetrachloracthyknc, and trichloroethylene. The total lipid and triglyceride contents increased proportionately to the fall in the ATP level before and after the exposure to 3 kinds of chlorinated hydrocarbons. It was suggested that there is some dose rela tionship between the decreased hepatic ATP levels and the de velopment of fatty liver in chlorinated hydrocarbon poisonings. B. V. Shetty 9623s laffaeoc* of subacute intoxication with mingiaooa chloride and carbon tetrachloride on the lethal dote of digitozia, lanatoside C, and strophanthoside in guinea pigs. Lence, 1*.; VxIentincie*Bu(iihna. Metka (Med. Pac., Ljubljana, Yugo slavia). /efoj/op. Pkystot. Pkurmocoi. Aeta 1966, 4(2), 1&7-4H (Eng). Id guinea pigs tlte toxicity of the title cardiotonic gluco* sides is modified in subacute intoxications with MnClt and CCi (when evident morphological changes are restricted to the liver). The following do*c* were used: U.UI ml./kg. CCU in 2% oil soln. and O.OH3 g./kg. MnCU in 3% aq. soln., i.ra.. twice a week, or 10 times successively; gtucosides were administered 30-39 days after the last dose of CCU or MnClt. In intoxicated guinea pigs the lethal dose of digitoxtn did not differ significantly from that of controls. The lethal dose of lanatoside C was sigm&caotly smaller only tn CCU treated animals and the lethal dose .f stro phanthoside was significantly smaller in both intoxicated groups. G- Muacevic 96241 Antidotes for phoegene-lndoeed pulmonary edema. Boyd, Eldon M. (Queen's L'mv., Kingston, Ont.). J. Pkarm. Pharmacol. 1669, 21(h), 537 (Eng). Death rates from phosgene were reduced m rabbits, cats, and rats if the animals were allowed to inhale the phosgene through the nose rather than directly into the trachea. David D. Sabine 9625o Demetbylphilloia. 1'uchingcr, Iferwig; Wicland, Theodor (Univ. Frankfurt, Frankfurt, Gcr.). Justus Lirbtti Ann. Ckm. 1669, 725, 236-40 (Gcr). DeincthylphaUoin^H (I) was obtained by redn. of the CO group of ketophalloidin with aH-labrled N4aBH. I had almost the same toxicity as phalloidin. During storage 1 gave a degradation product whose uv spectrum indicated a autforide structure. BTJG 9626t Histochemical study of cytochrome oxidase cad peeinie dehydrogenase activity ia encephalon of rabbits poisoned by alcohol. LoMento, G.; Chian, A. (Umv. Catania, Caunia, Italy). A/rd. Leg. Arsu-nraxioni 1966, 10(3-4), 163-72 (Eng), An increase in both cytochrome oxidase and succinic dchydro* grnasc was observed in the cells of the cerebellar cortex of rabbits which had undergone either chronic or acute ale. poisoning, as compared to the nonpoisoned control animals. No change was evident in other eucrphalic regions. The increase of these en zyme* at cerebellar level agrees with the symptomatologies data indicative of functional damage of the area during ale. poisoning. Mumc W, Burgas S0627w Nicotine degradation in hamsters and rata sad its modification by foreign substeoce*. 11. Effect of carbon mon oxide treatment of the animals on their nicotine metabolism. Harke, Hans P.; FraUm, B.; Schultz, Ch.; DontenwiU, \V. (Inst- Wiss. Forschungstelle Yerband, Cigarettenmd., Ham burg, Gcr.). Saturvntunnkafttn 1969, 5(Xfi), 416 (Ger). Deg radation of nicotine to cottmne tn rat and hamster liver homog enate* was not affected by prior exposure to CO. GK JG 9626s Toxic effects of calcium, titanium, and niobium boride* ia rats. Kasparov, a. A.; Zhtlova. N. A. (USSR). .Vgr, Dannyc Tokukol. Redk, Mttol. Ikk .Sotdin. 1967, 152*60 (Russ)- From Rcf.Zh., Farmakol.. Kkttmater. Steditva. Tokti hot. 1968. Abitf. No. 7.54.779. LDs of Call* (1). during i.p. administration to rats, was 1.045 rug..`kg. Intoxication with I is expressed by depression and disorder in movement coordina tion. Chronic oral administration of 1 to rabbit* (100 nig. 'kg./* day for 4 months) caused leukocytosis, lymphocytosis, increase in concn. of (wr-globulins and activity or aldolaic, and decrease ui albumin in blood. Prothrombin in blood at heKtomof de creased and then increased to the end of e*pt. In lungs tiler* was polyemta of tissues and thickening of interalveolar septum*. In intrstioes there was sclerosis of all vessels in subniucoml layer, decreased glycogen in liver, and accumulation of acid inueofMilyiicchande* m the region of hepatic triad. Moderate intensification of luttg pattern was observed by x-ray tiudies in animals (Ml months after tingle intratracheal administration to rats of Ti boride (II), Nb boride iIII), and esp. of 1 (SO ing.). 'jwssms :v=..- ,:a __ . - 'n i-aai ate | f|| j-., .. ------------------ -"''4 ' I..V. Zi -4asr* i: & -JO Hi: 1 's t fc- r'.'; f_ - t ~ - *! . , * . ,; 'i 33 CO uCO N3 N3 IO 3D 99 (/} w M to CO V-C-l * t-C'i ; ',l-J "u - --i "f . t-V 3 v.*.> .-3 * .v2 - ^.v" ni: ilosSn 111 1J--Biochemistry Vol. 71. 19^9 110973 animal*. The major difference lie*' in the tarter maintenance raquirements el the mouse due to its hither metabolic rate. Philip Jacobson 110561J Loveli of Imauaegtobuliaa (^O^M.^A) in normal Children. Tabata. Kihachiro (Kyoto Uaiv,, Kyoto. Japan). Skonik* JCiyo 1905. 14(0). 379-00 (Eng). Levels of serum immunoglobulin* were detd. by the antibody near place method m maternal and cord blood at the time of delivery and in groups of normal iafaoU and children up to age 15. ?A was absent from cord blood, yM present only m traces, whereas tbc levels of vG m cord blood were equal to or above those in maternal blood. Minimum levels of yG were found at 3 and 5 months, then rose lowly, not ettamiat the adult range until age 11. Levels of yM reached half the mate found in adults by 3 months, but did not marb adult levels until 3 ym. Level* of yA were less then half tk adult mate UP to aye 5. then rose rapidly. Jacob Sack* 115964k Pnljm*i|)liiiiii of transferrin* of bovine, pornno, and mIps aasn. as dotsiaijawl by maaas af acrylainida-gtl disc etaewaphaeoai*. Donicr. Joseph L. (Vniv. of lllinoia. Irbana, 111.)* 1965,65 pp. (Eng). Avail, fmv. Microfilms, Ann Arbor, Mich*. Order No. 6*10,657. Prom Du#. AkiU. B 1969, J9{ 12), 4737. &NDC 110965m HamgflsbM I spots Baltimore, a third typa of a Id grmaevor iP*). Quotas, Wolfram; Smith, Ernest Wendell (Sch.of U<4h Johns Hopkins Vniv., Baltimore. Md.L Ear. J. jisdm. )M9, 10(2)J7id(Ett|i. A new Lepoer-type lib m a pm of Nemo descent has hern identified. In this person a aw Hb (llbUpwu,itiM) **i delected. An abnormal Mdaa was isolated and fingerprinted. This hybrid-type pro- tem twmsmabiy inw as a consequent* of unequal crowding over batniau the 4 sad 4 gene*, as ws* cooctaded for llb-Lrporew gad Ifh I ipnatn n. n Is the new Lepvre-typ* lib dtunhul boa the uo--vr coadd be placed between residues I" and This typw of cm mover should oner with the highest frequency if Owoor enr a equally frequent between toy nucleotide* and if abetaa favors sm of the croasovve type*. RCDV 110564a Gi--tit gad ftuhiawhl rggnUttoB of btpatic Paadaoievuhnste dabydrataM m mac*. Doyle. Damll J ; trbikg, fcubetl T. iSch. of Med.. Stanford I'niv.. Stanford. Cald.). J. M. fkrm. 1969, WJ)l S+49-69 (Engl. The mduiM by wbwb the Irvuiimte km (bt) regulate* the tissue activity of I smimitmiituate dehydrate*# a mate has been etamd. The nasnyaMe hepatic catvnw activity in hmaocygous Lt* mouse Pam. iip<**n4 by G3TBI d, a between ooe-third #ud (At* hgk that uf faamueycoar Lr" strums. This difference m mrytoe gctrvny is dae to g fdinui to amt. if enzyme pnKtm as demon* muted by --nuanrhem. technique* with an antibody *petiftr for I ammmh i yhuate dehydratase. Combined immusorhrm. and aatapsc uduqsn show that the kmlflitt locus regulates the cwacu- at hepatic I aminnkvultnotc dehydratase by acting at the ftrvef of eatyiar tynkw. The rate of degradation id hepatic mryww a the same m both hv sod huh activity strains: when opmuf as a halfddc, da is equal to b-6 days. The pattern of f amianie*uiia*t detipdiatase development with ace is tmuiar in Itvera f bath tow aad high activity strain*. The tpeeft* activity of the ttrynt a high ia fetal liver, derm*#* during ;c rvvtal day* grew to berth, and increase* to the adult 1***1 during the hew J weeks of postnatal Me The activity of kirn no- Irmiuutr dehydratase is frtaj n also regulated bv i^r hevulinate tones. The rticyme m fetal l<*ee it appro* tw*e s* active tataJytwaUy as the enzyme ui sdult fiver irlatice to it* IsartMS as aa aattgeu. The fetal enivme &lv> apt*arx to he different m stability to heat and proteolytic inactivation IIjw- ever, legal and adult easymet are similar by other phvun hen uiUJia. mriodmg eketropboregic mobtlity, Mdunentativti *<#5.. aad A*, for the substrate. RCJN II0567p IduBUAeaboa and (ttetu coowal of two now lo- daaasty lipoprotein aUovypea. phouocroupa at tho Lpq locus Albers, John j.; Dray, Sheldon <Mfd. Center. 1'niv. of Jllmi'i*. Cbtcugo, Iff.). J. tmmmwU. 1969. liWiJ tEqg}. bee C4 99: KMdtOs. VN'JZ ll0965g Madiftfiriao by crude bistone* of ton* activity for lactata dabydratauaga. Latncr. A. L.: Longstaff, E. >kuy. Vsctona laftrmary, Newcastle upon Tyne. Engl.). .Ysfarr (Londou) 1969, ^J4t53l4>, 71-3 (Eng)- Addn. of crude ulf tbyrout htstonc to the mouse kidney organ culture m< rested the proportion of tbc lactntc dehydrugeosse 1 L.DH) iwuyinr* wHk h moved more rapidly toward the anode duimg tlectrophomi*. If a crude rut liver histuoc fractioo wa added to the culture, the increase was n the directmo of the slower moving LJ)H iwrymr*. In the culture* reposed to the crude calf thymus histone, the parent of LDH-1 and tne H subunit contribution to the total LDH activity significantly increased, whereas the opposite was found With the rat liver histone prepn.; LDH-5 and the M sul>> unit stgnificantly mcressed. Enrichment of the medium with ammo acid* present in the ca?' thymus histone prepn. did not alter the isozyme pattern. mdKatmc that the changes in I^DII pattern were not cau*ed by hydrolyn* of the Imtone. Gene, masking by histone* apparently is nmtspeetfic. and the vnide rst. may contain factors, not necessarily histones, which ^JJ **1** activity in a manner that i* not mwvic* specific. BSJN ]|0569r Changes in the activity of isolated vascular fsiootli mutcls la response to reduced osmolality, jonsson, Olof1 t^mv. (Voteborg, Goteborg. Sweil.). drta Phynul. .Vand. 1969. 7711), 191-^tW fEng). I'he effes't* of hypoosmolarity on the spoil- tanewus activity of the smooth musrJe m the tvilated portal vein of the rat have been studied in soln*. with varied ionic tompn. A comparison between the stnnuUtry effect* of lowered osmolahty and increased |K#|* fraternal K* concti.) indicate^ tliat at norma) |K*]4 in the control state the excitation caused_by hypo- tonHTity k not mediated only via change* in the | K ' I IK' I* ratio. The response to hypoosmolarity at a higher |K4|# s_. however, more readily explained by the change m |K*].|K*U whwh occur* in aasocn. with the swelling of ihe cell*. This might be attributed to the fart that the membrane potential of smooth muscle is more dependent nn the trunsmembrgne ronm. gradient for K * at higher level* of (K *). The stimulatnpr effect* of hypo- osmolarity are markedly reduced at a low (Na*j but are not considerably affected by comparable redn*. m |K*U or This indicate* that the tranimembrsne Na* gradient i* involved in the mechanism* by which hypoosmolarity notes the spon taneous activity of vascular smooth muscle. One possible interpretation is that the swelling of the ftiuvk cells in hypotome yiltn. cause* an increase in the iwmtcmbdity of the cell membrane to the relatively larger Na* K^\'Y 110570j Saeretios af rat paocrea* paifttaad with plaamg from rats fed soybean trypsin inhibitor. Khavambashi.il.; I.yman. H L, (I'mv. of Cahlomia. Urrkrley, Cald.)- .Iwn. J. /'imd. I960,31713). fifd-51 *Eng>. U*hen plasma from rat* frd w*yliean trypsin tnhdiitfir wa* perfuseii (hrnugh an i*Uln|, iiMfd rat pancreas. *niyla*c tecretion was greater than that of a pancreas perfused with plasma from fat* fed the same diet without trvpxin inhibitor. Addn. of atropine to the perfusate did nut inhibit the Memory response. The pU*ma factor wa* relatively unstable upon itoeage at 4* iSOfi lo** of activity m 4 day*) and appeared to be ataoxd. mainly with those plasma prmnn* of Itt.flflrt mol. wt. or fe**. Thus, active soybean trypm inhibitor enhanced the formation ami lor> release ol a hunntral pam rrory- mmltke substance that markedly stimulated external viiiyme leerrtxm of the rat pamrea*. KCDH 110971k Effect* of diet and catechol aminoa on bil* acid meUkoliam ig dop. Gan*. If.; Cater. NUfitvn H <Coll. of Med.. I'niv, of VernvHit. Uuilmictnn. Vt.v Amet. J. PirtiM. 1969, ^17<4\ 10lfc-_*4 'Enel. Five adult male dug* were uinmllr prepd. with t#dyvtn>; tubifig plaint the upfwr duodenum. Fjth ike wa* turn * huin'-*and and sample* of calltladder bile were vnh<!fmn over a I'Uilay jwiid The iaurtwho.V and poo) as 7^ kg Uaiv t. and I*.ill- bfe wa* 3 J day* when dw* were tivm a dtv dug lund diet. Fptfiephnne ;n ud, i*.m | m; K' day. nwrvawd plasma ha> le*(en>l coo^n*., prc*!urd a .l'1 redn. rn ihe taun*Indie avid pvil sue. and increased the rate M devhnrof iperiiii radMhietivity f )**th taur*.# holic ami t-iundeM**, hnbe at id-. 1 hr half-life uf taur*xh"li-*ur a. id during epinephrine ailmmi*tfatit>n at I day* Noretvnephnne m oil. OH to mg .'tee luv leg. djv, pr<Hluc-<l a m<alfM dnrease ;n tl;e half > fed tjur(*h*lic l,t`attd without .gmfirant e>vaimh* n p!a*;na i:n`le*trril t*n,n*. A dietary supplement *rf ' lb. beef pl* . 3 < tif clmfe*terd pv? day mulled at tiuTeased p)a*ma i'h-di^trrol iMijin*., intreaw* in th* iaur*hoiir afl pori utr. and a dntvase m the halfdife id aurtwhohr.,*(` rpmephi.'ie adtniMi'.traimn further in- ,rrawd r-a^ma thi!e^trroi cn< u* m ihlt*icru|-fed d.n-*-. Imt did not * vhiiV antly alter hue i rietat^ih-m R t` 1)11 110572m Effect of osmolanty on eamna rentl satcular reantance r.actua. S#r/i*`. Ni>tt. lerry Utiijauun; Chou. Chmc-Chung. Kaddy. Frsn^i* 1 (Michigan State I'niv . hast Lansing, Mich * ,lnee. J /`krii.-*, 1969. i.`l7-4*. *3 *F.n*i. Tie effe**tt id chance* m renal lWaal nsmolafity, jr*e <Ju< of by t low intraarterial <W mini. f dcstro*#, Nad. and urea, on renal rr*lamr were *> demaiKally tutml. in the dog. Infusion of a hyperosmotic vdn. of dextrose for ,1 min produced a (all in renal vj^ubf re*t<*anie whivh wa* sustainetl fur the entire mtu-ion pernl. On termination of the iiifuimn, resistance returmd in the cuiitrol level. Infusion of a *ln. of hypenwimtx' N'aCI or urea, on the otlier him!, produced a fall in resistance whnh waned with tune. I'urthermore. on stopping ihe infusion, resistance transiently ro*# well above the control level, particularly m the case'd urea. Intraarterial mfusHiu of an isosmotie snln. of urea and of hyposnmne soln*. of all three substance* produced large imrease* in resistance. Studies con- canting lymphatic ve**cl pressure and erll-frer perfusion, a* well a* the finding* of others, are consistent with the hypothesis tliat the change* in resistance result, to a large extent, from active vhomotion, possibly due tv o-iinote- change* m the water conirnt of the smooth muscle evil* RCDII 1I057JA MetcboUgm of alJyl compounds iA the rat, Clapp. J. J., Kave. C. M.J Young, Leslie Sr. Ihoma*'* Itosp. Med. .Vh., London, KstU- fti<w4ra. J. 1969, 114(1), til1 *1* ll'.ng). A mercaptuftc acid was isolated from the unite of rat* treated s.v- ? 3 '? mOilm 7/' !\o^3H - ^ > -.V'J ."H -` ' -j ` t> A. .v. v - -V*JriT^! ;. 3 ..O'y : .. ->; -* ' :. -* J-+'" '% T- ' with CHi:CHOAc or CHiiClfOIt tnd identified u 3-hydrnxy* propylmercnptunc odd (AT-acetyl-.V*(3*hydroxypropyU-L*<-ys toine, I). There wu no evidence for the pmrflct of allylmer* Capture acid (ALacetyl-.?-aliy|-i.-cysteine. II) in the urine of that animals. II, however, wu detected in the urine of ruts injected s.e. with CHi:CHCl, A'**llylglutathione, end .V-ailyl-L* cysteine. Rats treated with CH:C11C1 also excreted 1. Met* capture acids apparently arise by the reaction of ally) cumpds or their active derivs. with glutathione. BQJN ~~ 110874? Motabolitaa of octodotbipine eliminated In human tad rat urine. Quetsnerova, Milena; Svatrk, .; Metywva, Jtrma (Res. lost. I*harm. Biochem., Prague, Cxcch.). J. IPOO, lI4(2).33(M2(Rng). Four metabolites and utichaneed Ortociothcpmc were extd. with dk-hloroethanc from the urine of hnmans oven octoriothcptoe. These substances were nlatcd and purified by column and thui-layer chromatog. By chro- faataampbir, spectrophotometnc, and polarrsgraphic anal., vac hang* rt swtndothepme and 3 of the metabolites were identified InmwcfcwloUcjMBe, noroctocMhrptne A'-oxide. and octcxlothe* pot .Vmsk). The prnem-e of glurunuitdes in human urine The same cnrtabolita and unchanged oetoc h>t hepine *v*c alo found m rat tinne by thtwnutwg, RCFG 110573e Mochautm by which kacine and arftaine stimnlata inaim rmaana ta v*a. MUfirr, K. 1). O. *l`niv. West Indies, kiscuw, Jinsnk, fliurtm. B&pkrt, Aria IW, IWUi, 1&4-A (Cat'' Hod ntalit rrleaw in young rabbit pancreas stares an vitro was htcbrr m the immnr of leucine lAm.l/j tlcan d annnv ihsl/i (n the absence of glucose). Gluatun <5 *- mt.l. tbeWptiyllDie (lm.1/), dibwt)T>) rycla- AMP (ImA/). *r taHOisr i2ni/i stimulated laxuli* release in the presence of Imnsr tot wot n the feme ni argwmc. Argtaine-xtimuiated bnaal nwln rrkaw prehaps works by itkiunt clu*<rnfi fixwi the etdk. The swthannm of tV lm ine>mdoted stimuuintn is ddrr--t, pttdmhiy % ia the adewyl nvliw system. HbJ N I IflffTta Cytoehtminl atudy of the dieuiboboa and coateat of mdaspstHH and if i luKtwsd troop* of proteins an iso lated iwriiofts-- f the caatrai sinioi system following forcti a Mdi iiptSiS. Tsnasyu, K. L iKrrttn, Mid lint.. Fima. 13MU. A*J. Zk .irm. 1004, 22 .V. 97 S ku . Cpwhm ad vnrwms pans of rabbit central nervous system (ikfwlnt wtuni liiril tanclu. swrln <M the XI! crania) nerve, and afcsa watw area of lean cxaiei * displayed higher nUetn !e<*- pstiw iwiisi hi Mali main) with related i.v. oy'tMi of awwsl How itsa. Hw peek dfn t was .'rfn,4 to the 4th day after Ue tare a/nm X * change* were wen in ivntcmt ltd <sWitaa d pr Mexw Ml pmpi X taunr/uk 110577s OB A psbaas is mows# senbeyoak fibrobUft-Lke CoAate nm. masliWS by nnrnm factors. Vu. M . OdlmS, |. ki- (id'iiitfis, V 1 , hentwa. K, R 'M<*k (>*, ('w .Mww, t'S!*R>. />k/. ,(W. .V*a4 \\x* 1404. 1*7 4\ VIA- IbjCytoi! 'Raasi. Aatoendmcraphy was ink to follow the UNA lystlw in wnslr layer cwlturvs of nw eiohryo biaiS liii wtts a lartaibamoi bvdrulysatr and us wnim mku m the (Mwavd tbytaniiae *// i4tW4 at sartuo* pmvii uf iuitore ace. Thr a4n d *11 ihao was intrvawd by addn in- tsmlae w famsenal HyihiiMidtifi. KNiv, and dtcunom The twe of *M nuke seas tie mall of umititiio if the entry u tr.r iwAs sat* tW l^pf*ase d dweiitpcnewi M Kubliptfl (I0S7P ZAact d pregnancy oad oral cnatrareptivta ce [!< rrT H kmtit irmYilisni 7askmeti. Mar'# K />4<kr.iw 14*4, KVih. 474-KJ A review T-,e eflm .( t-.m pf|BiBiy and oral riouuepinn o> dubrtH(e*ivu. an>l t; ry nay came detefiuratnai 4 cbatise tuferar.^c in )nwh:.y f>tneti. The wpnwa tends to ssanpvosate thn. bv rriiuiKr! *; ertetMw, abub leads to h>-partasal<ni*fti 4.t references _ _ I. ti.-Zewi 11051*1 Effect of pyndaaal S'*phoophat oa the strencth of Bli iff hSi llatkiHn, Robert |> m\ Co!! [.iimliin, Lon don, Eatl). tlxpftf*!** 1444. ,,'V pt . O , j.nt Imi- ant with |(ha,l/ pynduval ,V-y(KK|ih4tr >lnti v.ir* rrtluir<! the lUtnstb of rat tail skin |^r*rewvr)y suh tunc of in^ututi-m The reda. was fesrfaibJe, with streneth leiurnm en t!'c nags were plated in buffrml ulmr FyndoiAm* <e or y>r. doiiae at lOmif had no comparable effect Thr ei!e\t of I redwted m the (Xmar of loiiw. Frrtfruiineiit of the skin with XaBH.. loHnvrd by wasiuttc in salme lai^er. lircelv mlnJctci the effect of f. I'retreat meat with NIL* >11 aU> mhibitrd the effect of I. Treatment with NMiOH after ! prevented the re cnecry of strength on ailw^uent transfer to the saline buffer: HaXXlIf had a similar effect, lhe effect of I on km itrntrili is apparently brought about by rupture uf axomethine Ititkaert farmed between an aldehyde and an amino croup HSfN' 1108Mb DUbetagiaic effect of L-aiparagu&ase. Khan, Atfianultah: Adachi. M it sun; Hill. Jovph Ma, (*]a>hAn \Vjd- ley Inst* of Mol. hfrrf., Dallas, Tes ). J llm i\ndo*r\n<*l, Mrttk. 1444, 29(10), 1373-0 4ln;> l he effects of AVbnoivi <e/ L-aspafngmase i.'inO-.VMliS) I V. ki . v.i. wLuh has Iwvn used to imluce remission of human atute lymphatic and myelog enous leukemias m depletion of an ammo and essentia! for come neoplastic cells, on rabbit hluod and urinary riucose Irvek were tludinl. A <inw o( JI.IO IX'. L-as|i,raimivl:.. rvokJ hyper- glycemia and ulycosurta in most of the animals, this is equal to a dose which induced hyperglycemia when given to patients. All rabbit, rnrivinii 10,0)0 l.l'. L..,pa,inic/k*. or more *noed diabetogenic responses, but these effects were temporary (*-13 days) and were not a&socd. wdh any histological changes in the pancreatic islrti, except in I rabbit which showed islet hyaJimi*- tion. DDJN HOSSlp Effect of Bidrio on tha meUboliam of dietary com ponents by the bovine. Luwrey. K. S.; Bowman. Malcolm C.; Knox. F- E. (Coastal IMain Hxp. Sta., Agr. Res. St:v., Tilton, ('.a,). J. Dairy Sn. 1444. Mi(>-3 'ng). Sii stetn as'eraging 400 kg. m wt. were used in a swuehback trial to study the effect of spiking coni silage with 15.7 ppm. (0.24 mg.rkg. bndv wt.) of the firsttcide Bidrm (3-(dimethosyphosphinyloxy^ ,V..V-dimethyl-rf<-i rutonamidei n blood cholinesterase, digest ibility of dietary' components, utihxatioti of N. and rumen fermen tation. Uidrtn residue* were not fmmd cither in the urine or in the feces nf animals ingesting Hidnn. Axodrin, a metabolite of Hidrin. was n<g present in the feces of treated ammaU but aver aged 0.15ii ppin. in the urine. Based on uruie vol. this repre sented l./)^ of the ingested Bidrm- Blood rholmestrrase was depressetl to ,10't of pretreatmmt values by the end of the 42^1ay eept). period, whereas atnvity vf steers fe<l untreated sdige was unaffected. In the tn*t*boltm trial conducted during the last 14 da>t f the 42-day pt-nod Hulrm liad no effect on the digest- ihility nf dietary' r<mTp.knents ulry matter, rude protem, ether ext-, crude M>ef, X-frcr ext . amt gross energy), the utilisation of \, or rumen fermr'itainkn RCI.I) 110$A2q Effect of a second dot* of cadmium salts on vascular prmetbiUr> in the rat tesut. Clegg, H. J.: Carr, Ian; Niemi, M M'tm Shcd;tld, Stieftield, Fngl... J, F.*d+r.aef, 1444, 43 ij\ JfiA-v *Knc'< Two doses *f CdCIi were given to rats at interval' varying from 74 to 144 days. After the wvood dose the blpd vessels in the trii and initial segment of the epididymis showed im reused pefmrabthty. as fem>nistraied by i.v. markers, to the trsfn. leaking vessel* were usually found in areas where interstitial celt* were abundant. UCkV HOSUr Add-base tnd electrolyte changes induced by scuts isotonk tatisc infusion in the nephrectonured doc. Rosenbaum. HaiTy J.; Mak.tff, Dwight L , Maxwell. Munon If.; Ilogh- <ughi. MkIucI Cela/s-Sinai Mexl. Res Inst- Los Angeles. Calif.). J Uk, a%m, Xfrd, 1444. 74 .*!. 427-33 (Fog). The iwi lianum and extent t*f "dilutMMi acidosix" I.v ante infusions of mt)g saline wax studies! in srphm lomired dugs. Infusions of ^i. And !<> m) kg of lawly wt. UU'Ht'truup*/, 7, ami ,1) ovet a 3i)-mm. peiresulted in exixaiellular fluid expansion* of 24 4 r I 7`.. ;N h - -2 2'i, and 33 t .`.5**, re*P- pCO| was kepi unit B'wtv xpat'e* were tneasuresl iv*tupnally, and mtra* eel'ular H* utivity bv .*.VdimeiSvI-2.4-Axioli<liiiedtone-HC. The estracrliulae Ikwarhunatect.iicn, dxs rrawxl only --2-4 t 0.7 mrq I #mf *2.3 t 'll meet 1 in t*r*ni;'- t and 7 and --3.0 I ii in <*,rnup J. The tots) smt of extracellular bicarbonate in- trea-ed --( d e 0 2 meq kg *f H\V, *(>,M 0,2 meq. kg. of B'A\ and * I j j 0 4 meq kg of U`.V :r, eaili group, rv*|i. Con* r<imiur*il\. the foul s*nt. W extra* *! u'sr fluid K increased +0.3 i <> f> itie<i k*rf |<W, +0 .* to) meq. kg nf UVV, and +0.4 - n.1 . . kg *( IUV. re*p . wtiile there wax nn drrreasr in t ,tr. e!iu #t K i '*1, i. It wax sugcextrd that t >r extra* * Uular bi* ji-Mit*- #r ' k r.* were deien.U'd by shifts *f |( * into cell* *>r tr- A/ts-Mtr <>ut *f >m lOiijuncteKi with a shift uf K is.it of if!!' Dr-j-Jte jhc pfesumei! II* '**r bharlxonate) flux, ti.-re wer*- n-i on * lunges *4 H* aitivity. The conceptual *.t'e*'rv ( f* r# elJular ,il;iuth,x atid'isix*' i* sglid 1'iUt uf limited marnitud* #;.! httte ri*:i. x.gnutksme when eipanxion is relatively ;<> CohiUr buffer,nf mimmitex tte extracellular acidosis. a*:d the stuft *4 k t^ui uf cells present* hypokalemia, RCKV IlCMas Effect of erythropoietin os boss marrow rt-amino- levvtimc acid cestheuse and hcm lynOitliif fi*Mt**mley, |v ui S . Vnth^. t '., Ann ' Vririjn* Kosp., Oklahoma C'tv, OVU i / hih. (Via .1/ed 743. 443 .V2 (Hng), A; m s'tr-* tulturr mr*)i**d lias hrcti a<l,ipte*l fc*r rabbit bone marr*w a*i I ha- permitted tm-isureinent **l the effect of erythro- jvjetin on A-aminfkitvulmii a* id synthetase and heme synthetase aiticiiies m marrow ceils. In this system, erythropoietin en- lu:.'e*l A aninKrtvuhnic ami svntlietaxc activity. This effect `4s iletextable as early axO hrs. after contact with er>'thp>poictin. I)-e max. eiiryme a. tmtv oltserved wii 2f*Fi greater m stim ulated than tn control cultures. Studies with inhibitors of pre^ tent synthros suggested that erythropoietin increased the xyn- thex'X of the eutyme. No stimulatory effect by erythropoietin on heme synthetase activity was oltservetl, RCKV l (OSftSt Actioo of adenosine triphosphate on the deproaacd ipootaneoua electrical activity of the dog cerebral cortex, lienti. f.i.ui; Arfipom, Lima. I;errara, A-. Mas*lierfia, 1*. tl>rp. IMtamukiol., Intv. Pavia. Pavia, Italy). J. I'h.trm .SVt. 1444, UHl-3 (line). The repeated suppression uf the ventda* turn and Die cir< uUtion nf the brain m the <I**k induces a high de pression or a xilrtice of cle*4. activity of tnr corticaJ and sub* cortical centers. The recovery oi respiratory and circulatory 30 B (0 CO to IO aiiku .4,.*s r'->' .fk v Fj?s* vv'i fi.i.EiUif, ,U?I T- ' MP, ifHr^ tt- r-"fr'> ------.*-,*** kttart+il ib liHriArririiw.x L-. \ '- -*- ' Y- 3 i V.~V- -- t. a. Toaaataow 4110*1 lUMhp ft Schottek. WoKfanf (AM. ArtoitMoiikoT, Holeweten*, Gtr.). On*. J-o*. (Leip. fif) 1*4*. 31(11). 700-11 (Of). A iwn* with 34 rtf.. Th* toxicity of vinyl chloride is uitnola and huinua. ond the relation of th* chem. dnttai of th* coenpd. to it* taucity wert die- tt***d. CCJG 4U10r MVrnWnyitelTy tontrnctod hanvy B*ttl l*tiic*tlo*. Avar anlOd* onto**, * method f*r locaiiaad hleinchexnlml 4- tacUaa *f haaey BMtalo la Ua*wM. Hudet, Gerhard (G*r.). lfilili*i 1*4*. 58(11). 272-5 (C*r). A lent* of wort a or* catcd which iUottnte* the ealae ft the rnmhinolioa ft lieht oi. rtueiupy with hiatacham. trduowi (or the detect**, locabj*- tioo. ud identihcaiiaa at H*. Pb, Bi, Fe. Zn. ud Co w cell* and theae*. HifhUfhtaaf the wive* ailhd* hmochew. orueedTe 1ft pen**ted alaac With ii|tio*umt phn<nni*rpOe. t nh. Srihe G. Dthnbottel 41111* Pamhfrt ft lh* hamedynanfr. Hirheatiral. *ad mwphataclc cheap** ia aepeehaaetai aadatatb* *heth. St**. Ml, Knwtd IZ tfkt. Ajenaearahicn. AM. Lodi, Palaadi. Pfftttj Hif. lift. A*. 1***, 33(5). 401-50 fPxdl. A note* h t me at taethodi la dew- hiaodjoee *. tiinhna.. *ad at. plaf. theati. lhr motor * iheaeei a that. eh*. crpJml e tof hhlln . aart damapreaia^mandeanai-- Moo*repel i*e* l*ta lh at. |44 rtf*. V. fiatai 4Mltt tapnMB Bah. Vehadoh rlhtn law . homh. Iwnrti. r**K Cm*. Tha fofe. 1*0*. i*a-2ta (Ko*). Feed b* Law*. In* R dead, few .Mra V#t, K.V. Dwtorr wane, imtahif aad nhnt at Imi June* A.; Srihold, H. R. (Tulan* Unit., Covinftun, U.). rvof. Apft. Pharmatfl. 1*4*. I.V3). 434-31 <Eo*). The toxic tfleet, of ethylene flycol in avail m*c*i)ur iprcin * re potted. The coatpd. *** aditumetered ia the dnnkine w*ler *t coacn*. of 0.35-10'!*. And hntal. audit* were node *!irr acute end ebrona *dmini>tf*t*. With iherieeptionof few animal* (which hod Co ocolete cryttale in thr brmut). xwniAcanl pothol. nlleratioa* wet* limited to the kidney*. Anmtol* rrcetvinf 13 ml/ky or amre f ethylene flycol h*d Co o**l*le cry*ti* wilhio proeimol renol tvhalcv nod owed, tabular d**einrtioo. He- pvtr th* sbxence of cryualt ia uimh ttcetvmf < 15 ml Vx.dhM ihinanil*! dnatafe an* fiomd, hod uoeeoim mi urrtd m eotae nmmnk. aaffntm* tou edect of ethylene flytoi apari from i! mart neon to oxeJjc *ctd. 41120kg A rHaiiptlwliow rnmdf 11 thg RC2B f iM mt>wl arwa IV. Ca>inNgiyfa^ mshm--ivU* tC$t grmf. Stftta*, G. E.. Siwu, C Fr4, U. K-; liiftM*. L. H ; ll/IU*d. D. ft. Artrftftl. M4.|. (*.5. Qjowf4w M. .*. r*4 .41> W?( AD-Mg. j rf*. (Ea*,. a*i4. CFStt. rni r V A#I. /V' mi. IJJ. A <4 tW tf4tr, wKy, *4 tt C5 M.ffcrn ta Ci ft**#, ft* V M vjl Th* Mg pMMMt lf*lM Krt 4IW Uv * kwf 4aH *rt tit piMbHt/y <njpMhhi, I^ptl IMIi. tVv Ml VM iwnffpl si I A*l *> <Uy< |*W n>l Mil tfUHw 1*4 4pn)w iwtrmi firti iftfV ft Xio fVy **ff bh , l,1 ,* ft# ! ** inM H t.'kt Ni , ftp( *f H4 WM I Wifi Jl) * M# 4p Ifn ft tMftfaftgw ft*^ M (teat* igmivfi 0%mm4 *.* ft Wftftt * % U ik 1 i ^ Pm***' Un *** i.a*# r**ft /ftF. krftt* /*<M 1*44, *1 ft! * **/ T4 :*i. Hft tiwft im;^atl v fthf * M# tv * O !!* f|IIMA ( ** Mtai*a*l Ipfti eft iMIf ftftft ft*** **M*J< ^trtft wi .1 :r `^ ft- rd . a* 4 1 ` .^4.: I 2:^ ; a p .44 p.`4ft .: - - . . , . .. t ' H, , '* Vi*- 7* -- r_ 3 ja : ' , 1 S/1 . f'X fe: v *2!. .= aro^e-. 73; L=-' ':-r? :"7 ?J -- ..is .? -! '* , '7l . T, - -I , ; i 14--Toxlcotofy Vol. 73. 1970 5994 cardioframs. isd is cardiac, tnu), and lung morphol. The recommended nu. permissible conen. *u 0,3 mg of $b/m* if present is SbFi. John Howe Scott IS98U InlliMti of cadmium compounds on the (iMntiri taction, Tsvetkova, R, p, (Med. Inst. im. Sechenora, Mos cow, USSR). Gif. Tr. Prof. ZoM. 1970, 14(3). 21-3 (Russ). The effect produced by various Cd compds. on the generative function of 106 females working with alkali storage batteries and chem. reagents coutg. Cd and Zn was studied. The women were exposed to the effect of Cd compds. in concns. of 0.03-35 mg-m1. These concns. do not affect the menstrual cycle, the course ol testation/ and term of delivery. However, the wt. of children bora of these females differed significantly from that of neonates of nonesposed females. Espti. on vats divulged the functional effect of CdSOi on the estreus cycle in femalm. The wt. of preg nant females exposed to the action of CdSO and the wt. of new* bon rats were significantly below that in control animals. The liven of newborn rats born to.esposcd female rats contained 2.5 times as much Cd as those of the control animals. Within 3 Booths after delivery 7^} of control animals and 'Jbr} of treated rats died. After 7 months' exposure to Cd the wti. of the preg nant rats and control animals were not different. G. Muacevtc 65982b Action of the polycyclic aromatic hydrocarbon J.4- baatopyrasa on iaoUted mitochondria of normal and tumor cells. Ovethntkova, N. A.; Pettikrvith. S. B. (Inst. Chem. Natur. Compds.. Moscow. USSR). I*. A had. Souk SSSR. Set. Bud. 1970, (4), 618-20 (Rum). Respiration of rat liver mitochondria with succinate was markedly inhibited by 3,4-brnsopyrene when incubated for 15 mm at 26* in the dark, and wen more m when illuminated by long-wave uv light. Only a slight effect nf 3.4* bnuopymir was obsd. under similar conditions with mitochon* dtia from Jensen sarroma.'presumably due to disturbances m the cytochrome system. Petr Skrabanek 85963c Selenium. Hogue, Douglas E. (Dtp. of Amm. Sn_, CornellUniv., Ithaca. X.Y.). J. 1970.63<ft), 1135-7 (Eng). Se tniirity and deficiency in animals is reviewed with 27 refs. BCJX 850844 AccuuuiUtiou of maaganeae in rats dnriag expertmental nrnifnena tatoxiutua. Uoyadzhtev, V.; khslwhrva, L-; Denev, J. (Hop. Yama, Varna, Buir.K J. Emr. Tnutd. 1969, 2(4), 212-15 (Fr). The rlntnlniue of Mn is varowi* tissues of rata given WO mg Mu** (sola, of MnClt> kg onllv, every other day for GO days, was cmamd. In control animals, the highest (worn, of Mn was found in the adrenals, team. Im, kidneys, blood, and parietal booe followed in this order- Fvpil. Mn poisoning increased the rana. iu all tissues but it was highest in blood and Wain and lowest in liver. A canvlato*n existed between the accumulation of Mn and the duration of pnitnning, Run If. Zincvaf 85985a Sffact of alpha naphthyl iacthiocyanate on the liver af cheep and calvaa. Gopmath. C.; Ford, K. J. 11- f>*p. Vet. Clin. Stud.. Univ. Liverpool. Liverpool. P.ngl >. J. Potkoi. 1970, 100(4), 209 NO (Hugh wXaphthyl iui(hnr>Mttr (AXITX100, 400, or fkgtfng kg. intragastmally imreawd tvitti the diffuse ATPaw activity around the canalH-uh and (Hr situs*- oidal alk. phosphatase activity, and decraated glutamate rirhy- rfvDftssir, stsreime Irusatlium miuctew, and wteraw activity in calf and sheep liven. In the serum, wrflntol dehsdrogmaxr. glutamate dehydrogenase, and amuv activity bilirubin evneo. meleased, and Hrofuudphihakio Oraroiwe decreesod following AX1T administration- Hepatic pripiiul cells showed swelling, vacuolatioa. and loss of particulate xtainsfu; In addu. to the above changes, chronic tdminisiri(Mtt l A.NJT (50 of Idl mg/kg day) decreased the albumin*to.gk>(aiim ratio in the plasma and caused intrava^ular rad sell breakdown. DZJX 85986C Role of gutroiateftiaai absorption f kerooene m pro ducing putumonitia in doga. Wolfe. Bruce M.. ItpUur. Afmand E.; Shields. J. B. tSch. of Med.. St. Lmi.s Cniv.. St, Louis, Mo-). J. Prdtat. 1970, 76(G), **>7-73 <Fng`. After kerosene was injected directly into the stomachs of 7 pups. tume of the animals had any radio!, evidence of jUKiimiHiitiv while after death, 5 of the 7 had histol. suggestions of edema. One li*d a focal hemoeriiage. DCJ X S987g Solar simulator sunacreen evaluation* in guinea pigs. YankcU, Samuel; Martin, Garland X.; Piechuia.ll-, Hmkeft. W. A.; Dolan, Margaret M. (Smith Kline and French Ltd.. Montreal. Cau.). J. Aur. Cerawf. Ckem. 1970. 2IK>. 607-12 (Gng). Eight sunscreen prepas. contg. such active ingredient* as iirawyi*pA,,.Y*dimr<hyUimftab*ftfDate, homomruthyl saiicylate. and p-ammobenaoic acid, wrre evaluated on guinea pigs with eaptl.-ioduced erythema both with and without trashing after application. On the nontrashed site, most of the sunscreens tested protected from irradn. ranging from I mio. rrythemal dose (MED) to 3 When sunscreen sites were nnsed with water, only noemyle.,V,.V*fim*ihylaminobentoeie in *.V,' EtOII ale. ur hydroalc lotion with emollients and pamtnnbmsiuc add in 7.V, KtOII slviwed protection at 1 MED; 2 of these prriint showed some protection from higher exposures. DZJX I598fth Pathology of wioyl chlorid*. Viola, 1'. Luigi (1st. Patol. Gen.. Univ. I'erugia, Perugia, Italy). Mtd. Lu: 1970, 61(3), 174-60 (Eng). Twenty-five rats after being exposed to vapors of vinyl chloride (3tMNK) ppm) 4 hr day 5 days a week for 12 month* were sacrificed in lots at 2d*day inimaN. After 10 months some animals shown] a decrease in wt. and aggressiveness to outside stimuli and disturbed equil. Thirteen animals dird from cardiorespiratory complications. Two tmttuh dud from hematopentoneum. Most of the animals showed jhitlud. de generation of the brain, liver, kidneys, and thyroid. Sis rats showed histopathol. alterations of the skeleton. Degeneration of the skeleton and connective tissue was similar to that oloervc-d in human acroosteolysis of the hands. L. D. Pagimttu 85989) Pathomorpholugieal changes in the lung* during experiment* involving boron carbide and corundum dust. Rrunshtcm, l. P.; Danilova, R. 1. il'rb. Nauch.-lsslvd. Inst. Sanit., Gig. Pitiful**!,, USSR). Mtd-Zk. I tb. 1900, U2.4-2 (Russ). Stale rats 11.5 month old * were given btfn carlnde ami cvrundum dust intrairacheally m a d'*c of A* mg ttd of physiol, saline. The dust of various lioproiniis rottUnind aU>ut i AliO. The animats were killrd after 3. !, and 12 months. IntoricatiuO with dust resulted in inffamniator) prnrvws with penhironchral and tenvavuhr hIoiw*. S>mie animals had catarrhal pneumonia. The prrmrabihty f the arterial wall imm'cd and dystrophy of tonnestivt tis^ie. nuvtl l>y destnu - linn of the proi'dlagen comjdev. cauwd rtluular pneumt*-- tenisis, M. Slavikova 65990c Eftibryotoiie actions of trypan bio* in mice in relation lo the time of administration. SMurt^r. <. `Inst. 7`osikJ., Farbenfahnken Hayrr ),(., \Yupt<*rtal-M1*rfr!tl. ('*cr.t. Sonmyn^Sikmtitdfbrtti .1*, k. f'L*rmutkri. 1970. 2!* ;* (CWr). Mur received 1 s,*.. injevtom of tryjiaii Idtoe 1 l,B| mg kg* at days f> 14 of pregnamy. Injetiion at day H ouvil lu<lir( prrrrotages of rrwirptions or fnaliormatums notably rxeit- cephaly). Injection at days M to 14 tuiv growth vrtarilaiion. J Dulren**> 659914 Production of atherosclerosis in UthytUic aorta* of ret*. Il'Oiida, Vasuhito. Swruhi, Mmm lw-p *,( Pathol , Raylog C<dl. of Med., Houston, To.1979. 3f4), 267- 7i* tKng*. Wranhoc male rats mimnr .1 *m*i*i*.. pwmitnle funurate iRAPN* i".r, ftf 3 *rrk. amt led an atherogenic d*et supplemrntrtl with .2', M \PV (* t wevki. and with IM1, R.\PX for 9 wtrks exhibit'd yros utility] .4 the aorta in as early as 3 weeks. Ihsws ts| .f (!* *4t were (iilol with prtddrratmg tneil.al itlis ami m t1** sutwod.*- Ihehat rone, the scuu**th ihuslr nlh ere nt<<d ith macrophage*, Between tie ini am) urntrot aninu'v t*t. <( the map*r srfom lipid IfMti'.ms wrt M^no*antis iMftrmt, ties iXMlKatmg that latent* xhan*rs *4 tat "..)% a* nee repair <4 damag'd me)i4 Im rt,ia^ ,ni:n^; h|i*i lera^ot*ofi. C * | N 5992* Hutolofkal and btstochemKal pattw* of the leslr* of rat* evpoacd to carbon dtaulhde. (**atd/ik. Mo an Akatt. Mr<! , inm P/land`> /`*'s /W 1979 .1 1,** r t IVJ i. In rat* Us i p adnitm-ifat x >, 1 .* .a . VHg kf evTfy *>t>ier day h*f l,'**ias . . anl strop,1.* !.a>ces were e. t! *|rryt"Oi.. r' "< and I'llerstiliai t;s*ur when fie nw sg -I . sa* * n rv*f than dav t, Imsefs.tnhly ol fa , . o |s*.luLitd 650ojf Pathogeneits of ashetiotis Si%t*v > * k - . r k n lad I*cp Itol !rd Mol . I > / J' */s4 ,\i lit BmJ. iV70, Ml. li* Iv M* hue lh* .r*-f stnwturr *4 iire*.i!- iU'i>n t aiui i^iulti i* rr-|e*n'-*,4e l.g tl*eif similar r*oxiH>- U*l itx*i Juim.I |ni in><o(i cltanges in u:ne4 in*:* *! */a* * f a-t *!*-* ""ry, Bimirphow* t *,;! n*.t kr>ot t aiol suan* siae i* anils to, n awt llie O '-tttwmvptem <4 wiisai, ..I wh.lt ni*e at;d t` e ckttmlm fra't**n*4 rabUi (,ypnf <aruni ,<*?iipar( *!" anwifphou* I. uaj Just. Mer cU%. and <r> :.i" rotiV asbesttt* lau*ry w*rker* iri the *ml as.ttw . which hove higli'# au u* cl Uiurf Mafv hasr a hirlt* r ns hIcimc *4 ashrst*sts than woiUrs m |Ot4rair> 4*pi* . *re i'w l4 conm. is highest lU IN 65994g Inhibitwo of the acute ethanol induced fatty liver by pyralolf Mtrfgan. J C . D<- J u/>. Ncltclj- R Sli cf M*d . IuUqc I'iiis.. Xr Orleans, la v, Etp Bt.>' tferf. 1979. |.T4' J , 4d_* i) ipiwi Shit pxn/**lr s|h>'to ally inUilnt* liver ale. ilrlivdnti'ritiv and imtu:rs n>e mtijh-IiMii tf h.tOII, itodiA were undertaken m rat* t,< exaluate fl<r mdutme >4 inhibition of KtOII melaluhsm n the drs-h>pmrnt i4 an a< ute EtOH-indused fatts User. In arcvemmi wtfli prrvnmx oleweva. turns. 2>t hr after KtOII adinmistiotcn a tmrrj** iti hrpatu tnglycende enmn. twiurrtd. In mirknl c>nirj*i, tlie p\rar*de- and HtOH-treated group showed tcmplete iiihilntiiin tf l;tOII- induced hepatic tnrlytrfule aciumulatuici. The prevention of the EtOH-tndureri hepatic tngl>rerde actumulatHHi isrurtvtl in the presence of enltaiued bU**l F.tOH xiinvu*. m the psratole group. The CCh-induted fatty liver and plasma hypotriglyx * endemi* was not mollified by pyraxole, tietiotitig specificity in 'i u-wv f^ r ^ '- yyi 76 ' ;Sf3 ' , 2 ' ' TsitlW ' , -:. .v/^J ^1 ~S T > ' *>Vt V,' - - 7rS ' V, >* *. ; i ..i 3D 't -a C/> - n pfc CO . Vf ro ro "vi .1 ;1 mi,Ataro, W. R. (Dip. BkL, Unr, SouU Ktond*, Twnp,. Ha.), ft*. CW v. AMI), 7S-*> (Em) EMM mma tumor Natal i.ntil IwtoTW d IW mm mi wmiM im ImiMi alia* tad Uoad to wttlc tm .hr mrtott ti i'u ihdn la MMl MMim. WMi Uw taaor ndi sad lynphiMytH acre MM to didscM ilida, tbBMsl dmtunlioa s4 the dseiy- tflSMIS lullsmi in (DNP) ns [Tuts in the tumor nils. When th* tn *U types stn aM and stInched on common ilidn, tbs DNP thermal dsantmstioa m cmtir in the lymphocytes and aidtine oenuted at a hither temp, in both cell types. This fihllnu held ntaidkm of the relative proportions of other cell type in a mist. However, when the tumor cells constituted I he Mjority cell type, the didcresses in DNP thermal stability was i of hbook origin transplanted la Abdnlla, Ahmad M.; Olivers John A. (Gavin Mite Mem. Caaccf Found.. R. Victoria Hosp., Mon treal, Quo*). J. Uni. 1971. 100(4), 590-4 (Eng). A tran- ptoflfHc arciimni mi propagated in the hamster with evident c MUiniim that it it a 4^methylchQlaatiirene-tran*fumifd w dnomn. Roland S. Pianutti U72r Dynamic* of RITA oocrftfoa lata a cattura medium" by Bhrilch firlnmw call* la a abort-ttvod enlture. kyarant- am, I. N. (USSR). Sb. Atpir. Rob., Kazan. Gat. L mv.t ftfnfr. Namki 1969, 199-32 (Rims). Edited by Belyaeva. M. I. Kama. Goa. Uni?,: Kaaaa, Ukr. USSR. The Ehrlich car* edit hamatod the 6th day altc tmotplaniatioo were centrifuged from the sadtie fluid, the damaae waa controlled by staining with neutral rod, and the cdls {2-6 X 10*/ml > incubated far 9*34 hr at 37" in Hanks sola, with 10% inactivated calf serum. Tbe 2<ual mmpies of the medium were taken at 30-min intervals. The cell* retained their physiol, activity for 3-4 hr. tbe dead cells averaging Using the ar incorporation into RNA and a quant. RNA detn. the RN'A content in the adis ami la the medium waa studied. RNA secretion into the medium teamed during the incubation from 21.1 af/ml at the *!*"jf to 32.9 at 2J6 hr. At the 3-5-hr interval, when the smetk odl* mrpansd the active oocs, the secretion rate de meaned to 21.4 nf/mi. Ivo Kunvtyr 2173a Eton tjs--part in aadtoa tumor calls. Guenther, Th.; Dora* F. (Zentraliast* Btochem. Biophy*., Freie Univ., Berlin, Gar,). Z. Kim. CMa, Klim. Bvrkam. 1971, 915), 438-12 (Gmjs Uptake and rdeane of *Zn by asrire* tumor cells erv Independent of ceil metabolism. SH reagents increased the rate of both uptake and relearn of *Zn. The rate of Zn transport was decreased by incubauon at 0" and by changes ia pH. IVotrins of the cell membrane are probably involved ia Zo transport. Accumulation of 2a it attributed to complex formation within the tdl# . V. N. Neknusotf 23741 OacCak massnei of rat skin. lunp. and bones to vM chloride. Viola, P. A,; Bifotti, A. (kextna Elena Inst. Caacar Res.. Rome, Italy). Canrtr fits. 1971, 31(5), SIA-TJ (Bag). Rats caponed for 12 months to vinyl chloride vapors (a coast, flow mi air coats. 3% voi./vol., 4 hr/day, 5 days/week) developed skin, lung, and bone tumors. The cutaneous system l waa the moat susceptible. " 237Su poeitbte import-- of the rtadlac mechanism of DNA la rnrrt--pniris Lowdia, P. O. (Dcp. Quantum Chem., Uppeak Uak.. Uppsala. Swcd.). Phyt.-Chem. Mtck. Gnrnnog., Pm. Imi. Symp. I96fl (Pub. 1909), 203-7 (Eng). Edited by * B. D. Isr. Acad. 5d. Hum.: Jerusalem, Iviri. if involve damage to the protein (or other) ed" part of the DMA code. Reading the ____ _ portion would produce normal protein*, but m the wrong ceils, against which iaumtaoi. ddcnui might not operate. Aaal. of the proteinsof raaiigssat cells it proposed. J. Bunvan 2379a Radloflobtslla * and inuntmaspocidclty la te trgifpkntrfl hmaaa ahoriacaitlaome* Mizrjewski. Gerald i, Jom; Bartm, Jennifer (Gen. Med* kes.. Veterans ___ Hosp., Ana Arbor, Mich.). Amur. J. Obtui. Gymtcoi. 1971, 111(3), 413-18 (Eng). Uwaan choriocarcinoma trmns- fdaat* la hamstm cheek pouches coned, both railndabelcd im* MX aad Aonimtnunc rabbit immunO|k>bulin G <IgG) as sliown hr radionutov** immtiaoduoreacmce, and >pe% trometric anal, lag intravascular activity and ia vivo immunoapcMfictty of lariingjrhiilin prvpae, was shwwn by usuix unuxxed w ludr rabbit PA as hlockiag agents# Uataggcd rabbit aat*hutnaa ihiriuoK ptedotropia serum could faiudt tsdwopte it tumor and sn In owaaaas4. wsnxasw nIM wrs ifawf swm iUtoan*r aui smw m4 amaaaac Uatw we* am* uw to<4 iK< a iw iww, ttwo (tws rmrnHr tsUwa let, wpsaae, I'wsUr aaksams in tie twwr`i Mrmsti I<0 sgtm m i. U. Usisifl Xjytw f inis iffPsw a kmu kaimd sad kypenrophk pear. I. kdtMs. kitvf, Hwtt R . fcrm*oa, Albert (Ftp. rSrt. Imai, Natl. Mwi Un| 1'Ul., ikttinds. Md.). >)rf F*mm WM. LV. 9 MeaMirvtaewt of imihm bydAisyUw* totmy 11 is *km iMihitn well with the rate d rdhidi lysdwu. this uudy kwpuw 1 ia kekad. hypertrophic war, and wamaJ skm tJ humans, la skin, 1 was assayed by inrubuting mani of >kin for &) min with a bid. prepd. I'f/iiXirfinr Ubrfa) pruionliiini substrate a the presence d eserss rdacwi. Tlte results tndnate that the rate d cd- Ugen produi'ttoa a meawirru by 1 Mgniikanfiy elevated in keloid* and hypmropiHt uar> end partly explains the abnormal ediarm iiniowti-*n in t)ie*e ute* Sidney Wrist 2l7ia Carsotaas eosenaa synthetiaa of the liver aad hep atoma. Panhta, A. V; Lednicva, S. B. <Naurhn^l--led Inst. Onkd, im. Petrova. Leningrad, USSR). Oakl. Akmd. Kami SSSK 1971, 2 k>(3), 736 V i&iurhemj (Ruts). The biAiyntlmti Of rarnoune and anserine in tbe liver of healthy mice a* cumpered to tliat with animal* with hepatoma and it was *hown ttut tlie tumor formation did not aflect the liver activity toward nrn^inc cynthrut in any meaningful way. The work ua* dune with %SQ tracing of Unine and histidine residue*. r,. M. Kuwktpnfl 2379y Effect of lymphosarcoma on contest of aulfbydryt sad disulfide groups tn tomor-beanne animal organs Dadyko, T. 1.: Novikova. E. N, (I'SHK) Zdrut*>vkhr. Brlarutt. 1970, No. 6, 47-^4) iUiuO. From Rtf, /A., Aid, Khtm. 1970. Abstr. No. lQM.'Oit. Content uf SH and -^itogroups in the Wood serum drcfeaied gradually m tali uilh l'h** lymphosarcoma during tumor development; mm. content of SfI groups in the liver corresponded to thrir max. content m tumor tissue. Coo- tent of Sf 1-groups increased and -&S-groups decreased during tumor tissue growth. Z3&0S Subtlity of chromatographic patterns of amiaaacyl traaslor ribooudelc add from individual mouse plasmacytomas aad variability among different uamuDOglobBlia A producing plasmacytomas and normal organa. Musbinski, J. Frederic (Lab. Ceil. Riot., Natl. Cancer lost., Bcthcsda, Md.). * dumislrt 1971, 1UCJ1)* 3917-24 (Eng). The leucyl-, seryl-, and tyrosyl-tkNAs from IxA-producing plasmacytomas amt normal tissues w*f* compared using fevefsed-phase cliromatog. The biol. stability of these chmmatof. patterns mas established by comparing the patterns of these aminoacybtkNAi from different uampUnt generations of a single tumor line, which were found to be very simiiar. Confirmation of the concept that such pettems reflect a stable population of luwccepting spectea of tRNA comes from the finding that the tkNAs from two dif ferent tumor lines which originated in the iame primary mouse have the same partem* for the three ammwicyJ*tk\As examd. Four normal tissues examd. in this way howia<i almost no varia tion iu the chrmnaiog. pattern of tymsyl-CKNA, small dtfleroicea in Irucyj.tRNA, and son.rwiiat greater differences in seryl- tRNA patterns. Four plasma cell tumors which secrete IgA inmiUBOglubulins with antibody activity showed pattern dif ferences tuiofli tliern.se!v which were much more striking than the differences among the normal organs. 1'nsMble sources of this variable decree of pattern variation are discussed. ;j81t Hi^ndine decarboxvlasa in the transplantable argyr^ phiUc gastric carcinoid of faiemy* natalensia. Hosoda* S.; Nakamura, W.; Snell, K. C.; Stewart. i|. L. <t*ab. Pathol.. Aiciii Cancer Cent. Res. Inst., Nagoya, Japan). Btrnktm, PKatmarof 1971, `JOfpti, UflTl-6 (Eng). A tmosplantaWc argysopliilic gastric carcinoid of Praomti sth/rasir contained appreciable activities of specific histidine accarbosyUse and ammatic cells, probably histamine<onte. argytophit cells dis tributed in the gastric mucu>a. Specific nistuiine decarboxylase fne front aromatic L-ammo acid derarboxyUsc was purified KMohi by aetd plu* heat treatment and stif>^equeiit (Nl()iSO pptn.: it was not e*vcntilty different from that ptvpd. from other mammalian wsmi. ZJ82u Autoradiographic studies on cellular proliferation la vivo of human gastric mucosa in normal and pathologic con ditions. after artenai perfusion of tritiated tbvnudina. Matvo- nu>to, lla^ime Scornrt Dep. Fathol., Kyoto ITriect, Univ. Med., Kyoto, Japan). Ky*no Fnrattt Ik* /hipiix Zoukr 1971. HX7), 39U-418 (Japan). lioUiiuc gluctwe soin. runtg thymidine- *H was injected into an artery r*f gamine cancer twttcuts with an injection pr**-ufe dight'v above the systolic pressure; th* dura tion of injection was Uhiully almut -i>) min. Tlie labeling index- (LI) was almost equal at *nv site of the tumor. The Ll was given for various type* *t u^'Iumiii. 'Hierc uu u, difference in LJ of gastric isran<><ui and itn >aMattc rarcmnnia in the lymph nodes. Chtomc ga-lntis was found in noni-ancefuus regions around the tumor, W. K- Kim bK^w ' fft ryitii vHivctir.il1 ' 99ti[ 1*4!]' BIOCHEMISTRY 12947-12964 tr .gimti. The peptide consisted of 9 kinds of amino acid. In this preparation one peptide may be linked to the phosphate of terminal adenylic acid through lls amino terminal, serine, as phosphoamlde. --Authors. 112947. LINDLEY, H. (Commonwlth. Set. and Indust, Res. Organ., ^klboume, Australia.) The rt-nfiion of Ihlol compounds and chloroBtrtamldc. 2. The reaction hrturrn chloroacctamlde and cysteine ocpIidcsT Dlochem. Jour. 8275):*Tl8-44$.-- lllus. 1962.--The theory of kinetics of the reaction between chloroacctamlde and amino thiols developed by Llndlcy (1900) has been further investigated. The reaction between four cysteine peptides and chloroacctamlde has been studied experimentally. For three of the peptides It appears probable that pKSH>PKNH]*: for ft* fourth peptide, glutathione, pKnHs* >pKsh> --Author. 12948. LISTER, J. H. (Inst. Cancer Res., London, England.) Svrtthesis of purines from pyrimidines. Revs. Pure and AddL Chem. uTiri^s^snriurmL------------------ 12949. LORAND. L. (Northwestern Unlv., Evanston, UL). W. T. BRANNEN Jr., and N. G. RULE. Thrombin-catalysed hydrolysis of p-nitrophcnyl esters. Arch. Blochem. and Blophys. 96(1); 147-161. Dlus. l56'2,--A scries of p-nttrophenyl esters, whose rates of basic hydrolysis varied over 100-fold, were synthesized. The thrombincatalyzed hydrolysis did not follow the relative order of the non-eozymlc breakdown of these substrates, but It showed a range of turnovers of about 2500-fold In going from p-nltrophenyl acetate through acetylglycinate, lodoacetate, acetyl-L-leuclnate, carbobenzoxyglyclnate to caibobenzoxy-L-phenylalanlnate and carbobenzoxy-L-tyroslnate. The latter two compounds are as good thrombin substrates as N-ptosyl-L-argtnlne methyl ester. It is concluded that the presence of an apolar phenyl side chain In the substrate molecule playa an Important part (n promoting Its hydrolysis by the enzyme.--L. Lorand. 12950. MAKINO, KATASHI, YOSHINORIJOH, and FUKUICffl BASEGAWA. (Jlkel Unlv. Sch. Med., Mlnatoku, Tokyo, Japan.) The detection of mausamine In the brain of mouse. Blochem. and Blophys. Res. Communications 6(6): 414-437. lllus. 1962. 12951. MILLS, J. A. (Commonwlth. Scl. and Indust. Res. Organ., Adelaide, Australia.) Association of polyhydroxy compounds with cations in solution. Blochem. and Blophys. Res. Communications 6(5); 418-421. lllus. 1962. ^J2952. MeNUTT, W. S. (Tufts Sch. Med., Boston, Mass.) The ^^jporatlon of the four normal atoma of purines Into the pyrimidine t^HpyTazlne rings of rlboflavTiu Jour. Amer. Chem. Soc, 83(10): zBS-2307. 1961.--The use ol NlS labeled adenine and N^ and C" labeled xanthine indicate that all of the atoma of carbon are incorporated into the 8 position in riboflavin by the yeast, Eremothecium ashbyll. --G. S. Rabldeau. 12953. OGLE, JAMES D., RALPH B. ARUNGHAUS, and MILAN A. LOGAN. (U. Cincinnati Coll. Med., Ohio.) Studies on peptides obtained lrom enzymic digests of collagen with evidence lor the presence of an unidentified compound In this protein. Arch. Blochem. and Blophys. 94(1): 85-9$. tllus. 1961.--Bovine achllles tendon collagen was hydrolyzed by the exoenzymes ot C. histolytlcum and by crude trypsin following heat denaturatlon. Thirty peptides, most of which contained proline and/or hydroxyprollne, were found in the acidic, neutral, and weakly basic fractions. These tractions represented 82% of the prollne, 89% of the hydroxyprollne, and only 15% of the arginine in collagen, with the exception of two trlpeptldes previously reported, none of the peptides accounted for over 1% of collagen, indicating that these peptide residues apparently do not repeat often In the collagen molecule. The sequence of five of the peptides was determined. The sequences were Gly.Ala.Hypro, Ala.Hypro, Gly.Pro.Arg, Gly.Glu, and Gly.XHypro where X refers to a residue not heretofore Identified In collagen. Thisunidentified compound has been Isolated from complete acid hydrolyzatbs of collagen. The results of preliminary studies on It are given. --Authors. 12954. OOMORI, SHINJL and SHUNZI MIZUHARA. (Okayama Unlv. Red. Sch., Japan.) Structure of a new sulfur-containing amino acid. Arch. Blochem. and'Oiophys. 96(1): 179-185. Ulus. 1962.--For the determination of the structure of a new sulfur-containing amino acid Isolated from the urine of hypercholesterolemie patients (A. Blochem. Blophys, 92: 53-57. 1961), the following compounds were synthesized: S-(lsopropylcarboxymethyl)cytelne (I), S-(l,l-dlmeftyl-2-czrboxyethyl) cysteine (II). S-(1.2-dlmethyl-2-carboxyelhyl)cystelne (HI), S-(2-ethyl2-carboxyeUiyl)cystelne (IV), S-(propyIcarboxymethyl)cystelne (V), B-(2-methyl-3-carbozypropyl)cyetelne (VI). The synthetic compound 0) ie Imind to be Identical with the new amtno acid In the following respects: infrared spectrum, Rf values on paper chromatogram, and elemental analysis. The new amino acid was named "lsovalthine'. --Authors. 5. OR6, J., snd A. P. KIMBALL. (U. Houston, Tex.) Synthesis under possible primitive earth conditions. L Adenine Irom hydrogen cyanide. Arch. Blochem. and Blophys. 94f2): 217-227. Dlus. 1*617--Adenine "has been synthesized In substantial amounts by heating a solution of hydrogen cyanide (1 to IS M) in aqueous ammonia for one or several days at moderate temperatures (27* to 100*), The Insoluble blsck polymer Of hydrogen cyanide was removed by centrifugation and adenine was isolated from the red-brown supernatant solution by chromatographic.methods. The main UV absorbing compound ol the reaction product was identified as adenine by 8 different procedures, among which, UV spectrophotometry, melting point of Its picrate, and the specific method of Gerlach and DOring were used. From a 11.1 M.hydrogen cyanide reaction mixture, at 70*, a yield of 110 mg of adenine per liter Of original reaction mixture was obtained, which could be Increased to 685 mg by evaporation ol the supernatant to dryness on the steam bath and subsequent treatment of the residue with hydrochloric acid. Since adenine Is an essential building block of nucleic acids and of the most Important coenzymcs, and since hydrogen cyanide, ammonia and water are common natural constituents Of the eolar system, theee experiments are considered of significance In relation to the problem ot the origin of life. In particular, the experiments provide the first demonstration of the spontaneous synthesis of adenine from simple compounds of carbon and nitrogen under conditions presumed to have existed on the primitive earth.--Authors. ^ 12958^ PAHREN, R. R., and D. E. BLOODGOOD. (Purdue U.. Lafayette, Indiana.) Biological oxidation of several vinyl compounds. Jour. Water Pollution Control Fed. 33(3): 233-238. 1981.--The progresa of biochemical oxidation of five vtnyl compounds including acrylic and methacryltc acid, methyl methacrylate, vinyl acetate, and styrene using an initial concentration of 10 r.ig per liter, employing carbon dioxide production as the oxidation parameter. None of the compounds resisted oxidation although methyl methacrylate was less readily attacked. Infra red analyses after several weeks revealed no Identifiable Inter mediate oxidation products or original Bubstrate. --Isaiah Gellman. 12957. RAFELSON, M. E. Jr., H. CLAUSER, and J. LEGAULTDEMARE. (Lab. Chlm. BloL, Boulevard Raspall, Paris, France.) Removal of sialic acid from serum gonadotropin by acidic and enzymic hydrolysis. BlocKlm. et Blophys. Acta 47(2): 406-407. lllus. 1961. 12958. RAMACHANDRAN, L. K. (Indian Inst. Set., Bangalore.) Elaatoldln-a mixture of three proteins. Blochem. and Blophys. Res. Communications 6(6): 443-448. lllus! 1962. 12959. SCHMID, K., and J. P. BINETTE. (Harvard Med. Sch., Boston, Mass.) Polymorphism of crl-actd glycoprotein. Nature 190(4776): 630-6317 Ulus. 1981. t 12960. SJdVALL, J. (Karollnska Inst., Stockholm, Sweden.), C. R. MELONI, and D. A. TURNER. A study of the separation of substituted cholanlc acids by gas-liquid chromatography. Jour. Lipid Rea. 2(4): 317-320. lllus. 1961.--Suitable conditions lor the gas-liquid chromatography of a number of substituted methyl cbolanates are described. The effects of various functional groups on the retention times have been studied, using as liquid phase two types of silicone gum rubbers differing in their content of phenyl groups. --Authors. 12961. REISFELD, R. A., et al. (Merck, Sharp and Dohme Res. Lab., Rahway, N. J.) Purification and characterization of sheen prolactin. Jtwr. Amer. Chera/Soc. 83(l7): 371l7-372?. 1961.--Column chromatography of sheep prolactin indicates a polypeptide chain with an Inter-chain disulfide linkage group.--G. S. Rabldeau. 12962. ROBERTS, JOHN D. [Editor-In-Chief,] Organic syntheses. An annual publication ol satisfactory methods for the preparation of organic chemicals. Vol. 41. ix+118p. John Wiley and Sons, Inc.: New York 16. 1961. Pr. $4.--As the subtitle implies this volume continues the excellent record of Its predecessors in presenting methods for preparing some 29 different compounds. All procedures have been rigorously checked, and are accompanied by detailed notes upon sources of materials and preferred laboratory techniques.--H. M. Vars. 12963. SHIFR1N, SIDNEY. (Natl. Inst. Health, Bethesda, Md.) Examination of side-chain Interactions In poly-L-trvptophan. Nature mum]-. 7&iTitiu*ns5L-- ----------- ---- t 12964. SLATER, E. C,, H. RUDNEY, J. BOUMAN, and J. LINKS. (U. Amsterdam, Netherlands.) The possibility of a-tocopherol In the respiratory chain. HI. The tocopherol and ubiquinone content ot heart-muscle preparation. Blochlm. et Blophys. Acta 4l(3): 497-S14. lllus. 1961.--(1) A procedure lor Isolating pure ublquinone-50 from horse heart 1s described. (2) A method of determining the ubiquinone content of heart and hcart-muecle preparation Is given. (3) Treatment of ubiquinone with ascorbic acid In HC1 In the presence of pyrogallol gtvee a reduction product, In about 30% yield, which is not the same as ublqutnol. Its properties suggest that It is ublchromanoi or a derivative thereof. (4) This product Is not distinguishable from a-tocopherol by the procedure previously used for measuring the a-tocopherol content of heart-muscle preparation and Is responsible for the 'extra otoeopherol' previously reported therein. (5) Vitamin Ki treated under similar conditions slso gives a stable reduction product which la also R&S 131228 1928-2836 TOXICOLOGY. GENERAL | Vol. 88] 272 R&S 131229 of tablet dust.] ARCH TOXIKOL 22(3): fS0-J58. IIIusTTSBS.--Three non-lethal poisonings due to Inhalation of dint during (ablctting of trifluoperazine (Strlaxlne, Jatrnneural) In a small factory are reported. Extrap) ramlrial reactions occurred In 2, and angina peetortn In the 3rd. Significant lymphocytosis occurred In 2; hemotoxic effect*, although prevlounly unreported, are possibly dangerous In Irlfluoperattne intoxications.--G. A, Emerson, 2928. PLUNKETT, E. F. Handbook of Industrial toxicology, rill* 480p. Chemical Publishing Company, Ini: New York, 1966. Pr. 816.50.--This book Is conveniently arranged for ready spotting of the various chemicals, drugs. Insecticides, and other compounds. The citric* are listed by thetr most familiar names from Abrln to Zirconium. Each entry has all the data that the seeker would need to know..synonyms, all aspects of toxicity, tests, treatment, and precautions to be observed, There Is a bibliography, and a subject index. 2929. SAKHNOVSKAYA, N. N. VUyanle uslovli vneshnei aredy na karttnu krovi naaelenlya, prozhivayushchego v zone Rozdol'skogo gornoknimicheskogo komblnata. (The effect of environmental conditions on the health of the population living near the Rozdol* Mining and Chemical Plant.) Inc Doklady I soobshcheniya L'vovskogo otdelenlya Geografirheskogo obshchestva Ukrainskol SSR za 1968 god. [Reports and communications of the L'vov Section of the Geographical Society of the Ukrainian SSR for 1968.] L'vov, Univ.: L'vov. 66-62. 1965. From: REF ZH OTD VYPUSK FARMAKOL KHIM1TERAP SREDSTVA TOK51KOL* 1966, No. 12.68.586. (Translatlon)--A study was made sf the condition of the peripheral blood In 300 persons (group 1) living for 3*8 years within 2 km of the sulfur-producing plant. The H-S content of the air In the residential zone exceeded the maximum single and also the average dally permissible concentrations. As controls, use was made of the population of a place 7 km from the plant (group 2) where the HjS levels were below the permissible values. The pathological changes in the blood in the area near the plant were observed in children and adults In about 65% of the cases. Women and children showed moderate erythropenia In conjunction with a low hemoglobin concentration; all categories examined in this group showed a rise in monocytes and a fail in segmented neutrophils; there was a rise in the number of stab leukocytes in glris, and adults showed a tendency to an increased number of eosinophils; in women and children the erythrocyte sedimentation rate was somewhat accelerated. The number of leukocytes in women of group 1 was clearly reduced but remained at the lower limit of normal. Changes in the morphological composition of the blood in children of group 2 were observed In 15% of the cases and in adults in 25%. Changes In the blood picture, which arc an Important parameter of the action of atmospheric contamination, make it possible to reveal initial changes in the body before the emergence of plain symptoms of disease. 2930. SCHONTNG, F. W. (Hautklin,, Johannes Gutenberg-Unlv., Mainz, West Ger.) Acrolein-Dermatitis im Beretch des aeuaseren maennUcben Genitale. (Acrolein dermatitis of the sexual organs of man,] BERUF5DEFMATOSEN 18(2): 98-99. Ulus. 1966. (Engl, and Pr. sum.]--The report deals with a deep gangrenous ulceration due to acrolein on the sexual organs of a 57 year old male worker in a chemical factory.--Author. 2931. SOLODUKHO, Yu. Z. Soatoyanle elektrolltnogo obmena u raboctukh v ualovlyakh deistvlya uglevodorodov nefti. (The condition of electrolyte metabolism in workers exposed to petroleum hydro carbons.) lit Materlalv Nauchnoi konferentsii. posvyashchennol voprosam gigleny truda, promyshlennol tokslkologtl 1 professional^ no! patologtl v neftyanol i neftekhlmlcheskol promyshlennostl, 1966. [Information on the 1966 scientific conference on problems of labor hygiene, industrial toxicology, and occupational pathology in the petroleum and petrochemical industry.] Baku. 98. 1966. From: REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA T0K5IK0L, 1967, No. 2.58.819. ("t 2932.') WILSON, REX K. (500 S. Main St., Akron, Ohio, USA.), "WILLIAM E. McCORMICK. CAFOLL F. TATUM, and JOHN U CREECH. Occupational acroosteolysls. J AMER MED ASS 201(8): 577-661. tlius. 1967.--In 3i cases of acroosteolysls of the hands of workmen associated with vinyl chlonde (CHjCHCl) polymerization processes, the osteolysis was specific to the distal phalange* of hands and was frequently associated with Raynaud's symptom*. Affected personnel ranged In age from 26 to 87. The disorder is believed to have resulted from a combination of physical Insult, chemical tnault, and * personal idiosyncrasy. The specific causee are unknown. The pre valence was found to be less than 3% among employees performing similar work. No cases were found in workmen using or processing the polymer or manufacturing commercial resins.--Authors. VETERINARY TOXICOLOGY (See also "Feeds and Feeding" under Animat production (Includes Fur-Beartng Animals); "Feeds and Feeding" under Poultry Production; "Pathology" under Veterinary Science) t 2933. CRUMP, M. H. (Dop. Vet. Physiol., Iowa Stale Univ., Amea, Iowa. USA.), E. B. SMALLEY, P. E, NICHOLS, and t). P. RAINEY. Pharmacologic properties ol a slobber-Inducing myrotoxln from fthlzocloma lerumifticola. AM HU J Vfcif RES ^8(128): 865-878. Ulus, 1967.--Dairy rattle, beef caltlc, sheep, pigs, chickens, and rata salivated intensely when force-fed extract* from pure cultures of Rhlzoctonla legumlnlrola. Individual guinea pigs differed In their response to crude extracts of the fungus. Doses causing death in 50% of 200- to 300-g guinea pigs were not lethal to 800- to 500-g guinea pigs. Sublcthal doses Induced salivation lasting 7 hr. or more, and salivation periodically fluctuated between Intense and no response in a given 30- min, period. Differences were not seen In the salivation response between male and female guinea pigs. Partially purified toxin (1 mg,/kg of body weight) was lethal to guinea pigs either forcefed or inoculated subcutaneously or intrapcrltoneally. Rectal temperature* of guinea pigs given lethal or aublethal doses decreased as much as 8 degrees below normal temperatures. Toxin action waa prevented by administering atropine or methanthcline bromide and delayed with hexamethonlum bromide. The toxin did not Inhibit blood cholinesterase, activity.' Signs of toxicosis in guinea pigs were lacrlBu tton, salivation,' frequent defecation, and urination; dyspnea occurred just before death. Postmortem lesions included enlarged, emphysema, tous lungs and centrolobular necrosis of the liver. Suffocation was the most probable cause of death.-- Authors. T 2938. GOODWIN, DAN E. (Wfnrock Farms, Morrilton, Arkansas, USA.) Ereot poisoning of cattle grazing dx|H* grass (Pasoalum dUatatum. Claviceps pasoalll. J AMER VET MED ASS 151(2): 208-205. Ulus. 1967.--Ergot poisoning occurred in 2 herds of cattle grazing Dalllsgrass. In both instances, large numbers of cattle were moved Into relatively small pastures that had been previously grazed by smaller numbers of susceptible animals without incident--Author. t 2935. KONDOS, A. C., and G. L. McCLYMONT. (Sch, Rural Sei., Univ. N. Engl., Armidale, N. S, W., AusL) Pharmacology and toxi cology of carbon tetrachloride in the sheen: IV. Reduction and aug mentation Of toxicity by selenium. AUST J AGR RES 18(8): 667682. Illus. 1967.--Susceptibility of sheep to toxic effects of carbon tetrachloride (CCU) was assessed by determining the increase in plasma levels of isocltric dehydrogenase (1CD) and glutamic trans aminase (GOT) and by other criteria. Susceptibility was increased by oral administration of 1 mg of selenium (Se) as sodium selenite plus 100 Lu. of tocopherol acetate on alternate day* for 120 days, 2 mg Se per day for 21 days, and 6 mg Se per day for 6 days, before dosing with CC18. Susceptibility was reduced by smaller total amounts of Se, and by oral doses of 6 mg Se per day for 3 days, a single oral or intramuscular dose of 5 or 12 mg c. 20 hr. or 5 or 12 mg orally 10-20 min, before dosing with CCI4. One 5 mg dose at 20 hr and a second 20 min before CC18 was more effective than either alone. Sheep from 2 different sources differed considerably in their susceptibility to CCI4. In the more susceptible sheep Se administra tion reduced susceptibility to a level comparable with that shown by the naturally resistant animals. Administration of Se to sheep dosed with CQ4 and then given a high-protein diet resulted in lower GOT levels, milder clinical Blgns, and a great reduction in mortality. In field teste on properties with a recent history of CCI4 poisoning, oral administration of 6 mg Se about 20 min before CCI4 significantly reduced susceptibility. Administration of Se to fluke-infested eheep did not protect the liver Quite (Fasciola heoatlca) against CCI4. --Authors, 2936. WESLEY, R. L. (Virginia Polytech. tost, Blacksburg, Virginia, USA.), A. R. STEMP, B, J. LBKA, and W. J. STADELMAN. Depletion of DDT from commercial layers. POULTRY SCI 85(2): 321-328. 1966.--Three groups of 50 Leghorn laying hens In single cages were administered DDT by capsule at 15 ppm (calculated on feed Intake) for 5 consecutive days. Group 1 was fed only Purdue standard laying ration. Group 2 and 3 were starved for18 hr. following final administration of DDT. Group 2 received 1/5 normal intake of a ration consisting of a complete pre-mix of all necessary vitamins and minerals plus soybean oil meal (50% protein), for 4 weeks, and then returned to full-feed. Group 3 received 1/5 their normal Intake for two weeks; then 3 lbs. cracked corn plus 3 lbs. of the standard laying ration for 2 more weeks and then returned to full-feed. At weekly intervals 3 birds were selected at random from each group and eacrUlced until each group was depelcted. One gram samples of abdominal fat were analyzed for DDT using flortsll clean up and electron capture gas chromatography. The yolks ol eggs laid by each group prior to slaughter were analyzed for DDT using the same method. Residual DDT in abdominal fat declined from 9.37, 9.55, end 9.75 ppm to 1.53, .35, and .60 ppm, in groups 1, 2, and 3, respectively in 13 weeks. Residual DDT In egg yolks declined from a peak of 4.58, 4.60 and 8.78 ppm to only .81, .15 and .38 ppm in groins 1, 2 and 3, respectively, in IT weeka, "Authors. 122362-122393 TOXICOLOGY, GENE UAL (VoL 49) U HO ' tlon of the rate of lo of lindane from both leaf and plana surface* as Influenced by temperature and humidity."Authors. 122382. STRELETS, N. N. K voproau o geneze smertl prl alkogol* nom op'yanrnll. |Thr problem of the cause of death in alcoholic drunk enness.) tr LENiSGItAb INST uSbvfnSFrVIUt'll (U. 154-155.----T5CBTTrom: REF Zll OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSIKOL, 1967, No. 12.64.1056. (Translation)--A description Is plven of the angiotroplc edema of the soft oalate and uvula occurring repeat edly In subjects observed after nervous stimulation and alcoholic drunk enness. It is suggested that the cause of death in alcoholic Intoxication In some persons can be mechanical asphyxia. 122383. TEREKHOV, Yu. A., and E. S. LEVASHOV. Ekranirovannaya satravochnaya kamera dtya tokstkologlchesklkh I rizlologlchesklkh Issledovantya. (A screened chamber for exposure to toxic substances lor toxics logical and physiological studies.| `fli UFlM NAUClf-IiJiJLtiriNJJT GIG PhOl ZAUOL3. 334-sib. 1966) 1967]. From: REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOK5IKOL: 1968, No. 2.54.738. 122384. TOSTANOVSKATA, A. A.. V. S. LAPCHENKO, V. E. RODIENKO, V. I. SVATKOV, and G. P. EGOROVA. Nekotorye dannye o komblntrovannom dclstvtl smesl DDT 1 khlorofosa v ostrom eksperlmente. [Some data on the combined action of a mixture of DDT and chloroPhoa In acute experiments. | liu Gtgicna pttantya. jThe hygiene pi nutri tion.) Kiev. 151-153. lade. From: HEF ZH OTD VTP FARMAKOL KHIMIOTER SREDSTVA TOKSIKOL, 1968, No. 2.54.864. (Translation)-- The DDT and chlorophos were given once, separately or mixed, lntragastrlcally, to rats at 1/2 of the LD50. The rats were killed 15 min. later when marked symptoms ol poisoning had developed. There was a rise in the blood sugar of all the animals, especially those given Chlorophos, In which It reached 124.4 mg%; there was a reduction In the liver glycogen Concentration which was greatest In rats gtven chlorophos (1.64%) and least In rats given DDT (2.89%); there was a reduction in the concentration of lipids, chiefly In the zona faaclculata when the mixture was given; the mixture also decreased the cholinest erase activity of the erythrocytes but less than DDT alone, while chloro phos alone Increased Its activity. In all the rats histological studies showed generally marked hemodynamic disorders. The (inferences tn the action of chlorophos and DDT given separately from the action of the mixture are emphasized. 1223B5. TOSTANOVSKAYA, A, A., V. S. LAPCHENKO, V. I. SVATKOV, G. P. EGOROVA, and V. E. GORDIENKO. (Kiev Res. Inst. Nutr. Hyg., Kiev, USSR.) O komblntrovannom delstvll DDT 1 khloro fosa, tlofosa 1 khlorofosa. ) Combined action of DDT with chlorophos and of thiophos with chlorophos. | vup PitaN 117(3): '69-13, 1968. fEngl. sum.j--lestb were conducted in albino rats by Instituting acute, subacute and chronic experiments with peroral introduction of the poisons. LD5Q was adopted as an initial dose in the mixtures taken at a ratio 1; 1. With a single introduction of the mixture comprising DDT and chlorophos there Is an antagonism with prevalent action of chloro phos, whereas in multiple administration, DDT appears predominant The mixture of thiophos with chlorophos is more potent than each one of these substances taken Individually.--Author*. _1223B6. VAZIN, A. N,, and E. I. PLOKHOVA. (Init. Ind. Hyg. Oecup. Die.,'Gor'kl, USSR.) K patogenezu zabolcvanlya, voznikayushchego prt khronlcheskom vozdelstvtl na organlzm khloristogo vinlla. f Pathogen esis of a disease, developing during chronic action of vinyl chloride on Ute organism.| FARMAKOL `TOKSIKOL 3l(3): 369-372. Ulus. 1966, )Engl. sum.)--Tests were conducted in rabbits to study the bio electric activity of the brain cortex, anterior and posterior groups of the hypothalamus nuclei, along with the pulse, arterial pressure and circulation rate during chronic poisonings of animals with vinyl chlor ide (In a concentration of 9--10 mg/llter. Evidence was produced show ing that, parallel with changes In the bioelectric acttvtty (appearance of 6-rhythms with a frequency of about 80 per/sec, rising mean bioelectric activity of the anterior and posterior groups of the hypothalamus nuclei) there appeared also changes In the circulation functions under study. It is inferred that in the mechanisms underlying the development of pathology secondary to a chronic effect of vinyl chloride a definite role Is played by the functional condition of the hypothalamua.--Authors. 122387. VINOKUROVA, M. K., and S. A. STEPANOV. Tokslkologtcheskaya kharakterlstlka gerbltslda fchlorazlna. fA toxicological character ization ot the herbicide chloraztnf2-chioro-4i6-bia-dlcthylamlno-s- *~ lrmine|,| in: tliglcna 1 toEsikologlya pestltstdov 1 kllnlka otravleniva. [The hygiene and toxicology of pesticides and clinical aspects of poison ing.) ZdoroVya: Kiev. 4. 175-178. 1966. From: REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSIKOL, 1968, No. 2.54.887. 122388. WEINSTEIN, I. (Vanderbilt Univ. Med. Sch,, Nashville, Tenn., USA.), L. WILLHITE, H. A. KLAUSNER, and M. HEIMBERG. The re quirement of free laity acids for the fatty liver of CCL Intoxication. T'HOCSOC EXP BtOL MED 127(3): B5U^5T~Hlus.lSW.~ livers Isolated surgically from normal animals and from rats intoxicated with CCI4 were perfused In vitro with a medium into which palmitic add was Infused continuously. Livers from normal rats were also treated with CCl^ In vitro by direct addition of the chlorinated hydrocarbon to the medium. Under these conditions, poisoning with CC1< resulted In In. hlbttlon of net release of triglyceride by the liver Into the pertusale and simultaneous accumulation of triglyceride In the liver. These ' observations support the hypothesis that the latty liver of CCI4 Into*- 1 lcatlon results primarily from Interference with the biochemical meek. antsms Involved In formation and release of the triglyceride tn the very low density lipoprotein ol the serum.--Author*. t 1 122389. ZYADDAROVA, S. A., M. N. KUKUNA, and E. V. TEPLYAK- OVA, (Leningrad Sanlt, Hyg, Med. Inst., Leningrad, USSR.) Ctglen- Icheskaya l toksikologlcheskaya kharakterlstlka preparatx khlorid chetvertlchnogo ammonievogo osnovaniya. [ Hygienic and toxicologic features of an ammonium tetrachloride base compound. | olt SanIt 33(5): 14-18. Ulus. 1906. (Kngl. sum.)--txperlmental investigation* Of a possible effect produced by the compound 34 (ammonium tetrachlor. Ide base) on organoleptic properties of water, the sanitary regime ot water bodies and the state of experimental animals in acute and chronic sanitary toxicologic tests showed that concentration* of this compound, occurring In the water as a detergent, should be limited according to it, effect on the sanitary regime, Its recommended maximum permissible concentration In water bodies t* set at a level of 0.05 mg/llter.--Authon FOOD RESIDUES, ADDITIVES AND PRESERVATIVES (See also Food Technology; "Veterinary Toxicology under Toxicology, General; "Disinfection and Vector Control (Includes Pesticides)under RibUc Health; "Insecticides; Chemical and niyslcal Con trol, Apparatus' under Economic Entomology (Includes Arachnoid* 122390. BAYZER, H. (Biol. Forschung Osterrelchle. Stlckstoff, A C Linz, Austria.) Nachwels und quantitative Beetlmmung von Chlonho) lnchlorid In btologlschen Material. (Detection and quantitative detent tlon of chlorocholln chloride In biological material. [ monaVsh CH! Oa(i): 1826-1831. 1967. [Engl. Sum.)--A method (or isolation and qy tltatlve determination of mlcrogram amounts of chlorochollne chlorl (CCC) extracted from green leave*, fruits, grains, straw, floor, etc. Is described. Quaternary ammonium compounds are separated by lea exchange column chromatography. Isolation of CCC by preparative thin Igybr chromatography on cellulose layers Is followed either by a quantitative colorimetric method using Iodine reagent or by a semiquantitative chromatographic method on cellulose thin layers.--Author*. t 122391. BUGG, JOHN C. Jr., JAMES E. HIGGINS, and ERIC A. ROBERTSON, Jr. (Humble Oil and Refining Co., New Orleans, La,, USA.) Chlorinated pesticide levels In the eastern oyster (Craasoatrq virginlea) from selected areas ol the South Atlantic and Gulf-ol-Mexlca. PESTIC MONIT J 1(3): 9-12. 1967.--Oysters were collected from estuarine areas tn South Carolina, Georgia, Florida, Mississippi, Louisiana, and Teias and analyzed for pesticide residues. Pesticide levels were determined by the electron capture gas chromatography method and were confirmed by thin layer chromatography and dual column electron capture gas chromatography. In general, chlorinated pesticides were either not detected or were found at relatively low levels In samples collected from the Atlantic and Gulf Coast areas. Of a total of 133 samples, 94.7% contained 1 or more pesticides; 89.5% contained 2 or more; 81.2% contained 3 or more; 63.9% con tained 4 or more; and 31.9% contatned 5 or more. The level o( sensiti vity for pesticide residues was 0.01 ppm. Some correlation was found between spraying operations and pesticide level* In the oysters. --Author). 1 * t 122392. CASPER. VICTOR L. (Gulf Coast Mar. Health Sci. Lab., Dauphin Island, Ala., USA.) Galveston Bay pesticide study: water and oyster sample analyzed lor pesticide residues following mosquito control program. PESTIC MONIT J 1(31: 13-15. Map. 1367.--The purpose of this study was to determine the effect of increased peettetde applications in the Houston area on shellfish and shellfish-growing waters of Galveston Bay, The study was conducted during the fall of 1964 following a large-scale mosquito control program In the Houston area. Water and osyter samples were collected In Sept, and Oct. 1964, during and alter the mosquito control operations. Oyster samples collected in this study were compared to samples collected from April to July 1964, prior to the mosquito operations. Analyses Included determination of levels of BHC-llndane, DDE, DDT, dleldrln, endrln, heptachlor, aldrtn, chlordane, heptachlor epoxide, methoxychlor, toxaphene, and Trtthlon. Pesticide level* were determined by the use of electron capture gas-llquld chromatog raphy, with thin layer chromatography for confirmation. Pesticide levels In both water and oysters were low at all times. The dats Indicate little or no Increase in levels due to the control program Is Houston.--Author. , 1 t 122393. DUGGAN, R. E. (Food and Drug Admin., Washington, D. C., USA.) Chlorinated pesticide residues In fluid milk and other dairy products In the United states PESTIC MCNIT J 1(3): 2-3. lSfir" The findings on 12,336 objective samples of milk and dairy products examined by the U. S. Food and Drug Administration from domestic and imported lots during the period July 1, 1963, through June 30, 1966, are reported. A majority ol the samples contatned pesticide residues. Residue* of DDT, DDE, IDE, dleldrln, heptachlor epoxide. 1 t 1 r e o L r. a e c t. v [; h Z N c P u O' Tt d if a A d T' h. u S' fl tt !> c'. It, t P tc 1. n d ai  3091.1 -3?h9 TOXICOLOGY |Vol, SO) 2m streptomycin jwnrMinlF, rtlhydroelrf'plrunyrln pxnthotcnatc, pasomycln, florlmyrln and knnamtcln arc prrm ntcd. Complex compound* at dlhydrostrcptomycln with ascorbic, panlholcnlc or p-amlnnsalyclllc rid *rr less loxtc than *trc|ttotnyetn millatc or dlhydrontrrplnmycln, AH above dthydrostrrptomycln drrlyallvri may be usrd In case* with aide rffrctn of streptomycin sulfate, Pasomycln Is preferable since It combines 2 main antttuhrrculou* preparations (dihydrostreptomycin and PAS). Flortmyeln and kanamycln are more toxic than streptomycin sulfate or dlhydrostrcptomycln and their derivatives. These antibiotics should be limited by patients with progressive processes and *trr|*omycin resistance. Flortmyeln and kanamycln are ototoxic and should be used only In stationary conditions wtth constant examination of hearing.--Authors. t 30951. TAYLOR, T. G., K. M. L. MORRIS, and JEAN KIRKLEY. (Agr. Res. Counc, Poultry Res. Cent., Edinburgh, Scot,, UK.) Effect of dietary excesses of vitamins A and D on some constituents of the blood of chicks,' tiRITJHUTft 22(4): 713-72^ IBfife.'-*Group* of chirks were given diets containing 4 levels of vitamins A and D, 1, 10, 100 and 1000 times the basal level, in all IS combinations, with the object of Investigating a possible antagonism between the 2 vitamins. Only diets containing 1000 times the basal level (approx. 1100 times the dietary requirements) of 1 or both vitamins depressed growth and Induced changes In the blood. The packed cell volume was substantially reduced from 4 wk of age In the chick* given the highest level of vitamin A. This was probably due to an effect of the vitamin on the fragility of the red cells and thus on their life span. Chicks given the toxic level of vitamin D showed an increase In plasma Ca and a decrease In plasma inorganic P. The highest level of vitamin A depressed plasma Ca without Influencing plasma inorganic P. Increasing amounts of vitamin A given In combination with the highest level of vitamin D caused a progressive Increase In the plasma Inorganic P. The highest level of dietary vitamin A significantly Increased the activity in the plasma of 3 lysosomal enzymes: add phosphatase, 0-glucuronidase and arylsulphatase. Excess vitamin D given in conjunction with the basal level of vitamin A significantly depressed the plasma acid phosphatase and the activity of this enzyme Increased 33 with Increasing amount* of vitamin A. Excess vitamin D had no Influence on the ether hydrolases studied. A marked antagonism between the effects of excessive amounts of the 2 vitamins occurred (/) only In respect of their action* on the plasma level* of Ca, Inorganic P and acid phosphatase, all of which are Involved In bone metabolism. --Authors. co 30952. TUMARXIN, R. I. (N. F. Gamaleya Inst. Epidemiol. Micro N3 biol., Acad. Med. Set. USSR, Moscow, USSR.) X voprosu o mekhanixms CO tokslcheskogo delstvlya antiblotlkov tetratslkllnovot gruppy na pechen*. (Mechanism of the toxic effect of the tetracvcline group of antibiotics on the "llvet-.T' AMTIblOTtKt "13(2): MT4SS. 1S8S. |fcngl, sum.| --fchlortetracycllne In high doses In rats increased histidine deaminase and urokaninaae activity. Oxytctracycllne had a slight effect on hlstidlnedeaminaae activity and suppressed urokanlnase activity. Tetra cycline effect was similar to that of oxytctracycllne. Chlortetracycllne has a higher toxicity.--Author. 30953. TYUL*MANKOV, V. N., and B. X. LUGOVSKR. Sosudlstye oslozhenentya prl lechenii pstkhtcheskl bol'nykh amlnazlnom. (Vascular complications during aminaaine fchlorbromazlne) treatment o? mental tntiema.r 2H REtlftOPATftL PflxhlAt 1m S 5 KORSAKOVA 68(1): 111-115. 1968. [Engl, sum,]--The main syndromes were cerebral hemorrhages and thrombotic vaacular affections of vitally important organs. Amlnazine probably Increases coagulability. A thorough control (Including laboratorlal and tests) of old patients sad ptlents wtth hypertensive disease must be made In the process of amlnazine treatment.--From auth. sum. t 30954. WEISS, HARVEY J. (Mt. Stnal Hosp., New York, N. Y., USA.), LOUIS M. ALEDORT, and SHAUL EOCHWA. The effect of ealtcylatos on the hemostatic properties of platelets In main. J CUN INVEST iffsyi 2169-2180. Ulus. 1968.--Ingestion of 1.5 g of aspirin, but not of sodium salicylate, produced a significant prolonga tion of the bleeding lime in 6 normal male subject! when compared with the effecta of a placebo. Similar differences In the effect of the 2 drugs on platelets was also observed. Aspirin Ingestion resulted In Impaired platelet aggregation by connective tlasue and waa associated with a decreased release of platelet ADP; sodium salicylate had no effect on these values. In vitro, Incubation of platelet-rich plasma with an optimum aspirin concentration of 0.045 mg/ml Inhibited both the adhesion of platelets to connective tissue and the release of ADP as well an the 2ndary wave of platelet aggregation produced with ADP or epinephrine. Sodium salicylate had no effect on these reactions, which were also normal In patients with von WUlcbrand'a disease. The Inhibitory effect produced by Ingesting a single 1.8 g dose of aspirin was detectable for 4-7 days at which time salicylate was no longer detectable In the blood, which suggested an Irreversible effect on the platelet. Aspirin also Inhibited the release of platelet ATP, but had no effect on the platelet surface charge, available platelet ATP or ADP, or the destruction of ADP by plasma ADPaae. These studies support the hypothesis that ingeatlon of aaplrln, In contrast to sodium salicylate, prolongs the bleeding time by Inhibiting the release of platelet ADP, perhaps reflecting the findings In other cell systems that aspirin alters membrane permeability.--Author!. 30955. ANONYMOUS. The kidney and oral calcium therapy. ANN INTERN MED 60(5): IMPTOH: rWT^TTimighTaCOj lf valuable as sn antacid, severe and possibly Irreversible injury to the kidney may occur from Its prolonged use In conjunction with s high mtlk Intake. Evidence of renal [unction disturbance may be shown by a rise In serum creatinine and renal N. During treatment with CaCOj a patient's serum Ca level should be watched tor early signs of Ca nephrofnthy within the 1st 7 days of treatment. INDUSTRIAL TOXICOLOGY (See also 'Pathology" under Respiratory System; "Environmental Health - 'Occupational Health,' and 'Radiation Health' " under Public Health) 30956. GANDEVIA, BRYAN. (Dtv. Thorac. Med., Unlv. N. S. W,, Sydney, N. S. W., Aust.) Pulmonary function In asbestos workers: A three-year follow-up study/ "AMH REV IttISP PIS 98(2): 427. Ulus. 1967. [Span, and Fr. sum.)--Ventilatory capacity and ventilatory response to a standard exercise test were measured In s series of 41 male workers in a factory making aabestos products, and was rspeated about 3 1/3 yr later. Twelve men left the Industry during the Intsrmln, They had a significantly lower vital capacity after adjustment for age, and a significantly higher ventilatory requirement for exerciae than those who remained In the industry. This pattern of functional abnormality contrasts wtth that found Is subjects admitting to peralstent cough and sputum, In whom a significant reduction was demonstrated In age-adjusted forced expiratory volume at 1 sec. In a control series, observed and predicted changes In pulmonary function over the observation period showed reasonable agreement. The asbestos workers showed a greater decrease in forced expiratory volume at 1 sec. than predicted, and poaslbly greater changes In vital capacity and ventilatory require ment for exercise. The trend toward functional abnormality Is con sistent with, although not indicative of, the development of asbestoslx. Serial pulmonary function tests are likely to be more informative than serial roentgenograms.--From auth. sum. t _30957,; HARRIS, D. KENWIN, and W, G. F. ADAMS. Acro-osteolysU occurring In men engaged In the polymerization of vinyl chloride. BRIT MED J 5567, 712-214. llius. 1967.--Two cases of aerooateolysls occurring In men engaged In the polymerization of vinyl chloride arc described. The bones affected were the terminal phalanges of the fingers and the aacrolUac Joints, but in 1 case the patella and In the other the phalanges of the feet were involved. The condition was-accompanied by Raynaud's phenomenon and akin lealcni. This condition Is prohably a self-limiting disease.--Authors, 30956. SAMEDOV, I. G. O nespetsiflcheskikh proyavleniyakh delstvlya uglevodorodov v malykh kontssntratslyakh. (Nonspecific manifestations of low concentrations of hydrocarbons. | AZERB MED ZK 6. 55-61"T8S7. "From: REF 2H 0T& VYP FARMAKOL KHIMIOTER SREDSTVA TOKSIKOL, 1968, No. 4.54.915. (Translation) --Workers were tested at a petroleum-processing plant where the concentration of hydrocarbon vapors did not exceed the maximum allowable (0.07-0.48 mg/1. Rabblta and guinea pigs were treated under varioua italic regimes with the vapors of gasoline B-70 at 0.95-1.1 ml/1, 4 hr/day, 6 tlmcs/week for 4 mo. The workers and the animals showed a rise In the concentration of blood acetylcholine and eptnephrtne-Uke substances. Animals treated constantly and evenly with increasing hydrocarbon concentrations showed these tendencies, but they were less marked. Chollnesteraae activity in the workers did not differ from that of controls, but it was reduced In treated animals, especially when the treatment waa with fluctuating concentrations of hydrocarbons. Pseudochollnesterase activity did not change In either persons or animals. Dally urinary excretion of 17-ketosterolds by treated rabbits was of a phasic character: the levated activity of the adrenocortical function waa soon replaced by reduced activity. Only under the action of sharply fluctuating hydrocarbon concentrations was there a prolonged rue In 17-kctosterold excretion. Maximum depression In the concentration of vitamins C and B] In the blood, urine, and organs was noted in animals treated with steadily and evenly Increasing and also sharply fluctuating hydrocarbon concentrations. Changes in the electrolyte metabolism with low concentrations was Insignificant. The princlpd changes with low hydrocarbon concentrations were In the functional condition of the autonomic and endocrine systems (changes in the metabolism of mediating substances and vitamins and in adreno cortical function). These changes are probably nonspecific and of a compensatory-adaptatlonal nature. Over a certain period they may lead to persistent snd even organic changes. , 30958. SPAK, IVAR. (Dep. Surg., Lanslasarettet, Hassleholm, Swsd.) Finger injury caused by paint spray gun ACTA CHIR 2981 SCA ln|e< com A sr of p Iron reac (See US/ and T5Twell the Ins (thf t 30 Ondt staff W of lc dese chol' of lc bein: men-, eirei fallu t 30 (Roe devf scr nuni 90% of tot snd 1 et thi at la< and t floor ealvt kerat preswere anlir to be fad c rcdui 30HOL Kale JCT. Swell blooc [mea cone mart jnsn were rece free stati nexec was With! reco in tt and < (See a 4829[i970] toxicology 48730 -49738 estlimitlon* were carried otX on blood specimens from more than 350 suggests that either continuous atr monitoring or breath analysla ndlvidiCtl* employed at urban and rural nervier xtallon.1. The results Is valid for entlmating (hr worker's Individual dally exposure to VC1. show that exposures to excessive concentrations of CO arc Infrequent and provides further evidence that breath analysis Is a useful Industrial and that clprelte smoke Is normally a more significant source of hygiene technique (or evaliollng vapor exposure. CO than m<*or vehicle exhaust pises. 09730. BUCKWALD. HERDERT. (Alberta Drp. Health, Ind. Health t 49735. PIMENTEL, J. CORTEZ, and FERNANDO MARQUES. (Pe. Med., UHlv., Lisbon, Port.) Vineyard sprayer's lung. A new occumtlonal ^5b., Edmonton, Alberta, Can.) A rapid and sensitive method for disease. THORAX 24(6): 678-088. lllus. 1969.--The mildew ol estlimtlnc earlinn monoxide'In blood and Its application In problem the vineyards Is prcvenled by the use of sprays with a soliklcn of copper areas, AMER IND IIYG ASS J 30(G): 504-569. Ulus. 1969.--The sulfate nciirallzcd with hydrated lime. The Inhalation of this solution speetroftiotometrie method of Commina and Lawther (1965) (or estimat while spraying may give rise to predominantly Interstitial pulmonary ing carbon monoxide In snail samples of blood (0.03 cm3) was adapted lesions which may lead to respiratory Insufficiency. These lesions, lor use In Industrial hygiene with particular reference to certain which were experimentally reproduced In guinea-pigs, have a well- problem areas. Blood specimens are collected and sealed Into short defined histological picture characterized by 3 stages--Intra-alveolar lengths of heparinized capillary tubing. Once sealed, the specimens desqiamatton of macrophages, formation of predominantly histiocytic will keep for several days allowing for delays such as mailing prior granulomas In the septa, and the healing of these lesions generally to analysis. The accuracy and limitations of the method are discussed. under the form of flbro-hyaline nodules very similar to (hose found In silicosis. These lesions contain variable amounts of copper. The patho t 49731. BUTLER, FRANK E. (Savannah River Lab., E. I. duPont de genesis of these lesions and the possibility of thetr regression when Nemours and Co., Aiken, S. C., USA.) Concentration of beryllium from the offending agent is removed are discussed; and the value of ling hloloqiral samples. AMER IND HYG ASS J 30(6): 559-563. lllus. biopsy and the necessity of protecting these workers are stressed. 1969.--| Beryllium is an extremely toxic element which must be handled under strict control to avoid health hazards to perstmnel.] Two new t 49736. TAYLCR, WILLIAM, HODA A. GUIRGIS, and WILLIAM K. methods for concentrating beryllium from biological samples are STEWART. (Dep. Soc. and Occup. Med., Dundee, Scot., UK.) investiga reported. Ole method is the exchange of beryllium from dilute HC1 tion of a population exposed to organomcrcurlat seed dressings, to dl-2-ethylhexyl phosphoric acid (HDEHP), This exchange requires ARCH ENVIRON HEALTH l9(4): 505-509. fllua. 1969.--Urinary 30 min of mixing, in the other method, beryllium as an oxalate anion mercury and protein o<*pi* rates, together with serum phosphoglucoee complex Is exchanged to trllsooctylamlne (TIOA) tn 10 sec. Although lsomerase activity, in 33 cereal seed dressers In East Scotland, neither method ts specific for beryllium, microgram quantities of the employed seasonally, were compared with 33 age-matched controls. element can be wpirated from gram quantltlea of solids. When 1 liter Increased mercury urinary concentrations, significant low-grade pro of urine that contained 7Be tracer was wet-ashed to 12 gm of Inorganic teinuria, and Inhibition of serum pbosphoglucose lsomerase were salts and concentrated by the TIOA method, 95%. of the tracer was found. Blood mercury concentrations were significantly higher than recovered, and only 6 mg of solids accompinted the ?Be, In other tests normal controls. The enzymic activity of glutathione reductase tn the of the TIOA method, 7Be In ten 250-ml urine samples was recovered sera of the seed dressers was within the normal range. There were at 98 + 1% (relative standard deviation), and stable 3Be In microgram no significant abnormalities in the electrocardiographic recordings amounts was separated from urine and analyzed by atomic absorption' In the seed dressers. The pathological and prognostic significance of spectrometry with similar recoveries. these abnormalities la incertain, but the results indicate the need for stricter protective measures. t 49732. llAUN, C. C. (SysteMed, Corp., Dayton, Ohio, USA.), E. H. VERNOT, D. L. GEIGER, and J. M. McNEP.NEY. The inhalation toxicity t 49737. RAY, R. P,, and W. R. SHILLER. (Nav. Submar. Med. Cent., of pyrolysis products of bromochloromcthane (CTly BrCl) and bromo- Groton, Conn., USA.) Salivary thiocyanate secretion during a fleet trlfluoromethane (CBrfX' AMER IND HYG ASS J 30(6): 551-554. ballistic missile submarine patrol. US NAV SUBMAR MED CENTER Ulus. 1969.--The inhalation toxlcttles (14-day LC50 values for 15-mln REP' 561. 1-4. 1969.--Tobacco smoke products make up an undeter exposures) of the pyrolysis products of 2 fire extinguisher compounds, mined amoult of the atmospheric contaminants of a fleet ballistic missile CH3BrCl and CBrFj, were determined for albino rats. Both compounds, submarine. A biological measurement of the degree of effective tobacco ently used by the USAF for aircraft fires, were pyrolyzed at 800"C Inhalation both in smokers and non-smokers would be a useful tool In drogen-oxygen Qarne. The principal constituents of the pyrolysis environmental health studies. Salivary thiocyanate levels seemed promis ucts were identified and quantitated. The determined LCjq value ing as such a tool. Thirty volunteers were selected from a submarine of 2300 ppm for pyrolyzed CBrF, produced a hydrogen fluoride concentra crew: 14 smokers and 16 non-smokers. Saliva was collected by stantbrd tion of 24 80 ppm consistent with the reported LG-a value for a single methods during refit and on patroL Thiocyanate content was measured 15-mln exposure to thlB ^s. The pyrolysis products generated from a and relationships ware sought with dietary, smoking and patrol tactors. concentration of 465 ppm of CHjBrCl killed 50% of rats exposed lor 15 Strong positive relationships were found between the thiocyanate levels min. The toxic response producing this LC50 value appeared to result and smoking, bi* no significant changes were found In either smokers lrom a mixture of hydrogen chloride, hydrogen bromide, and bromine gases. or nen-smokers on patrol. No relationships were found with dietary factors or with the amount smoked. R is concluded that the atmospheric effects are m* extreme enough to be detected by this biological method. t 49733. JOHNSON, DOUGLAS L., JEROME J. HEALEY, HOWARD E. AYER, and JEREMIAH R. LYNCH. (Bur. Occup. Safety and Health, 49738. H1NE, C. H. (Hine Lab., lnc,, San Francisco, Calif., ISA.), Cincinnati, Ohio, USA.) Exposure to fibers in the manufacture of R. D. CAVALLI, and S. M. BELTRAN. Percutaneous absorption of fibrous glass. AMER IND HYG ASS J 30(6): 545-550. lllus. 1969.-- lead from Industrial lubricants. J OCCUP MED 11(11): 568-575. As part of its study of health hazards associated with the manufacture 1969.--Experimental evaluation of lead naphthenate absorption as a and processing of fibrous materials, the Bureau of Occupational Safety component of Industrial greases and oils Indicated that such products and Health is conducting a cohort analysis of past workers in the fibrous would pass through rabbits' skin to give an elevation of blood lead glass Industry. Environmental surveys to estimate the degree of expos levels. No physiologic or pathologic changes were noted. The 20 applica ure of fibrous glass workers to fibers that are respirable indicated tions, to the skin of human volunteers, of a lead naphthenate-contalning that the exposure had been negligible. Preset* average concentrations oil having a total dose of 0.81 gm of lead also resulted In an elevation ol libers In air are low, as is the total airborne glass concentration. of the total body burden of lead, as Indicated by Increased urinary Concentration ranges and averages in glass fiber Insulation and glass excretion of lead and increased blood lead values. Skin lrrltatlm textile fiber manufacturing are compared with those existing in other did not occur, and would not serve as a significant warning property. mineral industries (or potential health Implications. No Indications of altered physiology or biochemistry, or lead Intoxication, were noted tn these persons or repeated observations. However, due ;t 49734. BARETTA, EDWARD D. (Mirquette Sch. Med., Milwaukee, to the cumulative properties of lead, the use of lead-naphthenate-contain- Wl5,, USA.), RICKARD D. STEWART, and JOHN E. MUTCHLER. Moni tng lubricants, wider conditions In which significant skin contact can be toring exposures to vinyl chloride vapor: Dreath analysis and continuous anticipated, should be accompanied by an adequately supervised industrial- air sampling. AMER IND HYG ASS J 30(6): 537-544. lllus. hygiene program.--J. W. S. 1969.--An environmental survey was conducted to determine the time- weighted average expoeure (TWA) ol a group of chemical plat* workers 49739. HASEGAWA, HIROMICHI. (Nat. Inst. Ind. Health, Tokyo, to vinyl chloride (VC1) vapor. This survey featured continuous multipoint Jap,) (A study Of methyl Iodide potsonlng.1 JAP J IND HEALTH air sampling and analysts using an IR spectrophotometer. The inhalation 11(2): 73-7iT, lllus. 1969. [In Jap. with Engl, sum.]--This study was exposure data were digitized and recorded on taper tape for subsequent carried out to discover some early diagnostic methods for man exposed compeer analysis and derivation of chilly TWA values (or each worker. to methyl Iodide or methyl bromide. When methyl Iodide was adminis A breath sampling program wan cinducted concurrently with the environ tered to rabbits, this substance was found in the brain, especially tn mental survey, and a scries of breath decay curves relating postexposurs the cerebral cortex, and in the liver and kidneys. Galt disturbance, breath concentration to vapor exposure were derived from the tftita. the most severe effect of methyl Iodide on the nervous system, seemed To validate the breath curves derived from on-the-job data, postexposurs to be represented as an Increase of d-tubocurarlne susceptibility h curves were also constricted from breath data obtained following of the rabbit. In this stats of the rabbit, abnormal metabolic patterns (mental human exposures to carefully controlled concentrations 1 vapor. The close agreement between postexposure breath concen trations st the corresponding TWA'a obtained by each of the methods of Uplds and of energy rich phosphate compounds such as decreased phosphatldylserlne, lecithin and ATP were observed in the brain. As reported previously, changes of ssrum proteins and U|*ds were R&S 131232 TOOQCOLOGY 38121-38132 to tM (invneits. dryness, only oil fthi tendency o{ aggregation and (nod rafiarMy of suspension, hydrophobic, precipitating silicic add p 500 causes Urpc dual concentrations in the case of open handling, pt use requires certain protective measures.--.!. W. S. 31121. BAGNOVA, M. D., and B. V. TEPLYAKOVA. (r. F. F.risman Moscow Res. Inst. Hyp., Moscow, USSR.) Proftlaktlka profrsslonal'nykh zabolevantl knzht v ustovtyakh prnlzvodstva novykh khimlchrsklkh veshrhestv, | Prevention of occupational diseases of tonkin In the production of new chemical substances.| KUN MED JJI3J. 114-I1U. I!dili7 fhngl. sum.)--New chemical substances, nllrlles and amines, are derivatives of fatty adds, the physico chemical proredlcs of which are still not adequately studied. Accord ing to the literature amines exert a marked effect on the skin, Irritate the mucous membranes, In [articular the eyes and upper respiratory I tract, awl are endowed with a great toxicity. Workers (211] were rum'ined at a plant where fat-substitutes were synthesized. In 18.6% ot rases occupational diseases of the tldn were found. In Industrial renditions the best treatment was achieved with paste on a soap basts. Polyethylene film Is the best matedal for the manufacture of pro tective gloves.--C. M. M. '^38122? ANTONYUZHENKO, V. A. 0 professlonal'not tntokslkatstl 1*villkh!orldoni. (Occupational poisoning by vinyl chlodde.( GIG TR PROF ZABOL 1213): 3U-52. lUtiB.--experiments were conducted m workers who were severely poisoned by vinyl chloride. Only the msnllestatton of the stage I of poisoning, was completely reversible. Beginning with Stage II, the majority of poisoning manifestations yielded poorly to treatment. In a number of cases, the poisoning was * progressive process, notwithstanding the cessation of the contact with the toxic substance and intensive treatment.--Auth. sum. transl. 33123. COMBA, G. (Inst. Nac. Med. Segur. Trab., Madrid, Siatn.) AporUcionea al estudlo de la lncapacldad labors! en los neumoconldtlcos. IStudv of work disability in pneumoconiosis.1 MED SEGUR TRAB HttDRIUJ UJ(5!/63): Di-UK: HIusT "lSBSfrecd. 1969], [Engl., Fr. lid Ger. sum.]--In the absence of substantial changes In breathing caiaclty, ergosplrometry is an Indtspenilble technique for determining work disability. The correlation between working ability and changes in the static and dynamic values of maximum breathing caiaclty was itudicd by determination of the various cardiopulmonary parameters I during the stable state of the overload. The results are presented. i --J. W. S. 31123. GABOR, S,, T. FRITS, and Z. ANCA. (Instlt. Hyg., Clu], Rum.) Contribution a l'etude du metabollsme Uptdlque des poumons dins la slllcose experlmentale, Chez le rat. (The study of the llptd i mrtihollsm In rat lungs during experimental silicosis,] AKC'ri MAL TOOF'MED TRAV SEC'TO SOC 30(7/8): 313-320. Ulus. 19S9.-Rats vtuch were made silicotic by intratracheal instillation of 40iog of I qiartz showed changes in the enzymatic activity during silica Instillation. Acid litase after an Initial decrease shown an Increased ltpolyttc activity during the stage of established silicosis. In the same way, the lipo protein-Upase shows increased activity during established silicosis |havlng presented oscillations In the early stages of the experimental diuease]. As for the pulmonary aconltaae, its activity decreases. The rate of tree fatty adds In the pulmonary tissue stays appreciably normal; on the other hand there is a noticeable decrease cd these uids In the blood serum throughout the evolution of the silicosis.--H. C. VETERINARY TOXICOLOGY ! 33125. CLARKE, E. C. C. (Roy. Vet. Coll., London, Engl., UK.) i fttsonlng In the pig f review]. BRIT VET J 125(6): 289-293. ! t 38126. FRIES, G. F-, G. S. MARROW, and C. H. GORDON. i tAajm. Husb. Res. Dlv., Bcltsvlllc, Md., USA.) Comparative excretton and retention of DDT analogs by dairy cows, J DAIRY SOI Wic. muo-mui. mus. lutiu.--Three groups"of 3 costs each were i Inf25 mg of p,p-DDT, p,p'-DDD, or p,p'-DDE per day tor 60days. Concentrations of the compounds In milk fat approached, but did not rrach, equilibrium during the feeding period. From 40 to 60 days, i 13.11 of the p,p -DDE, 7.6% of the p,p'-DDD, and 5.1% of the p.p'.DDT u p,p-DDT (2.1%) and p,p'-DDD (3.0%) were excreted In the milk. Men the tending of the compounds ended at 60 days, the decline In milk tat concentrations of all compounds could be described as the um of 2 lst-order terms. The Initial partial concentrations of ths 1m term were 0.41, 9.91, and 0.41 with rates of decline of 67, 41, end 317 per day tor p,p'-DDT, p,p'-DDD, and p,p'-DDE, respectively. Tie Jntttal psrtlal concentrations al the 2nd term were 0.59, 0.09, aM 0,59, with rstes of decline of 1.3, 2.6, and 1.3% per day, respectively. 3*127. WORD, J. D., U C. MARTIN, D. L. WILLIAMS, E. I. MLUAMS, R. J. RANCIERA, T. E. NELSON, and A. D. TILLMAN. IDrp.Antm.Sct., Ckla. Unlv.. Stillwater. Okla.. USA.) Urea toxicity |imir In the bovine. J ANIM SCI 29(5): 786-791. Illua. lflSB.-- Ins itmclty win produced In pregnant cows when dosed by drench with urea at a level nf 0.44 gmAg body weight. Symptoms of urea toxicity appeared within 10 min. Thin treatment proved fatal to eown which had heen previously fasted and then administered a 5% v/v solution of srettc acid at the rate of 2 moles of aretlc acid per mole of urea. A method was developed for handling pregnant cows to obtain high blood Nllj-N levels for a short period of lime but lo keep the cows alive. Cows were fed a poor-quality grass hay up to the time of urea administration. Four hr prior to urea administra tion, they were fed grain sorghum at a level of 5 gm/kg body weight for a standard weight of 352 kg with adjustment (or greater weights being made on the basts of W -75kg. When acetic aetd was given at the rale of 2 moles/mole of urea at 15 min and at the rate or 1 mole/ mole of urea 160 min after the urea was administered the animals survived. Using this procedure, 29 pregnant cows were treated and only 2 death occurred. Treated cows and their paired controls were kept under regular management conditions for another 12 mo. and treatment had no effect on number of calves bora, birth weight, weaning weight of the calves, or weight changes and rebreedlng performance ot the cows.--J. W. S. t 36128. CARR, S. B. (Vtt. Polytcch. Inst., Blacksburg, va.., USA.), and DON R. JACOBSON. Bovine physiological responses to toxic ser~ (lir nSZ-ngSnBea--fescue and related conditions for application In a btwssay. XTlAIRY 52 Physiological responses were ob. served tn 85 male Holstein calves In mostly paired comparisons for the ultimate development of a suitable bloassay technique for fescue toxicity. The effects of environmental temperature, level of feed Intake, orgotamlne tartrate, and extracts of both toxic fescue and nontoxic orchardgrass on skin temperature of the distal portion of the tall were recorded. The 80% ethanol extract from toxic fescue caused a significant decrease In tatl temperature, whereas nontoxtc orchardgrass did not. Some differences in heart and respiration rates occurred. Multiple correlation and regression analysis Indicated that room tem perature and level of feed Intake explained 57% of the variation In dally mean skin temperature of the tails of the animals In a room with continuous air movement. Complete removal of feed from the animals for 2 meals before obtaining measurements also caused reduced tatl ' temperature, heart rate, and respiration rate. The most consistent . response differences between presumably toxic and nontoxtc extracts were obtained the day of treatment for intrapentoneal administration and the day following treatment for oral administration. The assay procedure described employing skin temperature appears to be the most discriminating for detecting reduced blood flow resulting from the administration of extracts of toxic fescus. f 38129. MOUNT, DONALD J.. and CHARLES F. STEPHAN. (Nat. Water Contr. Lab., Duluth, Minn., USA.). Chronic toxicity of copper to the fathead minnow (Mmephales promelas) tn soft water, J FISH RES BOARD CAN 26(3): 2449-24577 1969--TSe maximum acceptable toxicant concentration of copper for the fathead minnow (Plmephales promelas, Raflnesque) in water having an EDTA hardness of 30 mg/liter (as CaCO^) was found to be between 0.13 and 0.22 of the 96-hr TL_ [median tolerance limits] value, using survival, growth, and reproduction to evaluate effect. In an earlier atudy the application factor for copper in water with an EDTA hardness at 200 mg/llter (as CaCp3) was found to be between 0.03 and 0.08 for the same spectes. Suggestions are made that should increase the accuracy and precision of future determinations of application factors. 38130. KRATZER, F. H., D. BANDY, M. WILEY, and A. N. BOOTH. (Agr. Ret. Serv.. Albany, Calif., USA.) Anatoxin eltects In poultry. PROC SOC EXP BIOL MED 131(4): 1281-1284. 1969.--A systematic study was made of the effect of graded level* of dietary anatoxin on the performance ot brollere under etmulated practical conditions. No adverse effects were detected when a ration containing 400 ppb aflatotln was fed to Arbor-Acres broiler chicks from 1 day to S wk of age. At higher levels (800 and 1600 ppb) adverse liver effects were detected, based on biochemical and hlatological studies. By chemical analysts, no evidence of anatoxin was found In the meat, liver or blood of broilers fed 1600 ppb for 60 days prior to elaughte'r, nor In the eggs, meat, liver, or blood of White Leghorn hens fed a ration containing 2700 ppb anatoxin for a period of 4B daya. t 38131. STUDIER, EUGENE H., and A. A. FRESQUEZ. (Biol. Dep., N. Mex. Highlands Univ., Las Vegas, N. Mex., USA.) Carbon dioxide. A mechanism of ammonia tolerance In mammals. ECOLOGY 50(3): 492-494. lllus. lltttw.-- When guano bats, taaarlda braslltcnslg,Inhale ammonia in air mixtures, CO2 Is passively retained In sufficient amounts to neutralise alkali excess resulting from increased blood ammonia levels. There le no change In blood CO2 levels In house mice, Mue musculue. Little brown bats, Myotls luclfugus, are intermediate tn this respect. Passive CO2 retention Is clearly related to ammonia toteranco In those animals. t 38132. VAN KAMPEN, KENT R., and LYNN F. JAMES. (Agr. Res. Serv., US. Dep. Agr., Logan, Utah, USA.) Acute Halogeton poisoning of sheep: Pathogenesis of lesions, AMkk j vlt kls 30(10): 1779I itu. uIusTlBeiJ,--Twelve mature sheep were given a lethal dose R&S 131233 . ' 43040-13950 TOXICOLOGY (VoL $1) 42( R&S 131234 Dlua. 1968|recd, 1969). (In Jap. with Enel, sum.]--For Die pollutants produced by exhaust pas from motor vehicles and blast Inc gas Iron dynamite, rarbon mono*Ido, nitrogen oxides and dust were determined Inside the Nlhonzaka Tunnel under construction for the Tokyo-Nagoya Expressway, The pollutants obtained near the blasting place showed high concentrations of carbon monoxide, nitrogen oxides and the Out, with levels of 350-1,200 ppm, 10-35 ppm, and 5,3-60.5 mg/in3, respectively. These results were due to defective ventilation, 43940. MIRKINA. K. S., and V. L ERMOUNSKH. O sluchayakh etrmvlenlya rtut'yu sredl medltstnsklkh rabotntkov. [Cases of mercury poisoning among medical workers,1 SB NAUCH TR KUIBYSHEV NAUC1I-ISSLED INST EPIDEMIOL GIG 5. 82-83. 1968. Translated from REF ZH OTD VYP FARMAKOL IQIIMIOTER SREDSTVA TOKSIKOL, 19G9, No. 5.54.725.--Observations were made of 4 cases of Hg poisoning In medical personnel as a result of Infraction ol the rules tor working with apparatus containing Hg. The studies, which were carried cut In several medical Institutions, revealed the presence of Hg In washings from equipment, walls, floors and In the air of the location. In a number of cases the concentration of Hg elgnlflcantly exceeded the maximum allowable concentration. Working with apparatus containing Hg can be a considerable danger when the rules lor safety techniquee are not observed. 43941. IVANOVA, L S., and M. M. MEL'NIKOVA. (Cent Inst. Postgrad. Med,, Moscow, USSR.) K voprosu o sostoyanll zdorov'ya rabochlkh v proizvodstve nltrofoskL [Problems regarding the health Conditions of workers in nitrogen-phosphorus-potassium IcrUlt-er factories.I GIG TR PROF ZABOL 12(12): 49-50. 1968.--Observa tions conducted on 187 workers, disclosed the presence of different degrees of bronchitis, which were observed In marked and fanctlonal disorders of the nervous system In the form of vegetative dysfunction. The effect of a number of aubatancea, having a stimulating effect (auch fcs chlorine and sulfurous compounds) had a significant role In ths development of bronchitis. Changes occurring In the nerve system are connected with the effect of a complex of chemical eubetances, --L. G. G. 43942. BUSHUEVA, T. L, E. A. ZABOZLAEVA, and A. Ya. YAKUBOV. K voprosu o delstvli yadokhimikatov na aktlvnost* syvorotochnykh fermentov 1 belkovuyu kxrttnu krovL [The action of chemical poisons on the serum enzyme activity and the blood protein picture.I TR TRADZH MED INST 96. 139-142. 1968. Translated from REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSIKOL, 1969, No. 8.54.939.--When cotton was being sprayed with organophosphorus Insecticides, the concentration ol them In the air of the working zona was 0.00002-0.002 mg/1. In the air of warehouse locations It was 0.0008-0.002 mg/1. When cotton was dusted with DDT from tractors, the concentration of It In the afr of the working zone was 0.002-0.04 mg/1. Ninety persons were examined before the beginning of the field work season when the chemical poisons were used and 36 were examined (hiring the season (6 of them were worklng wlth chemlal poisons lor the 1st time and the remainder had exposure histories from 1 to more than 5 yr). Before the beginning of work organophosphorus In secticides were not found In the blood of those examined. They were found In the blood of 50% of them (hiring the working srasan, A decrease waa noted In the serum cholinesterase and alanine amino transferase. There was also a decrease In the serum albumins and an Increase In the a j and gamma globulins and In the albumtn-to-globulln ratio. In some of those examined the thymol test was positive. These results are evaluated as the result of a disturbance of liver hmctlon. --S. T. 43943. POKROVSKH, V. A., A. S. FAUSTOV, and S. V. IVANOV. O peresmotre 1 utochenll predel'no dopusttmykh kontsentratsll benzoin, tohiola, ettlbenzola 1 dietlibenzola v voidukhe prolzvodstvennykh pomeshchenlL [Review and refinement of the maximum allowable concentrations of benzene, toluene, ethylbenzene, and dlcthvlbenzene In toe air o( Industrial locations, | TR VORONEZH MED INST 73T" 13-19. 1906. Translated from KEF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSIKOL, 1969, No. 4.54.869.--From the literature and experimental data on the toxicohyglenlc estimation of aromatic hydrocarbons, reduction of the maximum allowable concen tration In the atr of Industrial locations la recommended as follows: benzene, from 20 to 5 mg/ m3 and toluene from 50 to 10. The maximum allowable concentration for ethylbenzene as 5 mg/m3 and for diethyl benzene 10 mg/m3 remains the same. When estimates are made of the toxic action of the substances of a single homologous series, methods should be used which are adequate for this group of substances and they should be used In mil the laboratories developing the maximi m allowable concentrations. While their value Is being decided, there shtxild be obligatory conslderatlcm of the clinical material. 43944. PARAMONCHIK. V. M., and V. I. PLATONOVA. Q funktstoial' noni sostoyanll pechenl 1 zheludka u Ills, podverpyushchlkhsya tvozdelstviyu khlororgantcheskikh yadokhimikatov. [functional state 'of the liver and stoimch In people, affected bv organochlortde chemical poisons, | GIG 771 PltOF ZABOL 12(31: 27-3 LI 986. lEmri. sum.)-- Investlifatlims covered functional state of the liver and stomach In 70 persons handling organochlorous compounds (DDT, hexachlorane, ether sulfonate). Persons with a relatively short service record (up to 19 yr) had Increased acidic and pepsinogenous gastric functions and slightly pronounced disorders of the liver hmctlon. Inhibition of the acidic and pepsinogenous gastric hinctlons, along with a marked derangement of the proteldlne, carbohydrate, pigmental, antitoxic and secretory-function of the liver occurred In persons with a long servlet record (In excess of 10 yr) exposed to effects of organochlorous com pounds,--C. M. M. -'"43945. "VAZIN, A. N.. and E. I. PLOKHOVA. K iozdanlyu ekeperlmental'tiol modell "tokelchcekogo angloncvroza", voxntkayushchego pr| khronlcheskom vozdelstvll na organlzm parov vlnllkhlorlda. [Creation of an experimental model of 'toxic angloneurosls" developing front lh*~ chronic action of vinyl chloride vapors on an organism, | QIC! TR PROF ZABOL 12(7): 47-49, 1908.--In rabbits the chronic action o( vinyl chloride vapors at concentrations of 9-10 mg/lltcr alters the rate of cardiac contractions, disturbs the electrical and mechanical activity of the heart, changes the level of maximum arterial blood pressure and causes a reduction in the rate of linear blood flow. The changes described in the functions of the cardiovascular system In ike experimental rabbits Indicate that the model of the pathology which develops from the chronic action of vinyl chloride on an organism an be uaelitl for studying questions of the pathogenesis and experimental therapy of toxic angloneurosls. 43946. GRATSIANSKAYA, L. N,, and E. N. SOLOV'EVA. Prlehbiy dlltel'not Invalldnostl prl khronichesklkh professlonal'nykh tntokslkatil- yakh. [Reasons for orolonged invalidism during chronic occuoattoml Intoxication,[ GIG TR PROF ZABOL 12(8): [fcngl. ~ sum.j--Case histories of 187 persons Incapacitated by chronic poleonlni with Mn, gasoline, benzene substances and Pb were analyzed (starting from the beginning of Invalidism), The follow-up period averaged 6,5 yr, InveetlgUlons showed perilstance at clinical manifestations ef poisoning despite discontinuation of any exposure to the effects at talc substances. Causes responsible for the continued Incapacitation of individuals trained and untrained for new occupations were analyzed. A medical approach to treating these 2 groups of patients was suggested --CM.il 43947, APEL' Ya. A. Materlaly k toksikologit nekotorykh promezhnto. drnykh prodiktov prl proizvodstve lzoprenovogo kauchuka. [Infornatlm on the toxicology of some intermediate predicts in the production of lsoprene rubber. 1 SB nXuCH~TR KUIBYSHEV NAUCH-ISSLED tNST EPIDEMIOL GIG 5. 87-88. 1968. From: REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSIKOL, 1969, No. 1.54.885. 4 I * ' 43948. TILLER, J. R., R. S. 7. SCHILLING, and J. N. MORRIS. 1 (London Seh. Hyg. and Trop. Me<L, London, Engl., UK.) Occupational talc factor in mortality from coronary heart disease. BRIT MED J 4(5628): 407-411. Ulus. 1968.--Between 1933 and 1962 42% of 223 deaths of male workers exposed to carbon disulfide In 3 viscose rayon factories In England and Wales were certified to coronary heart disease--compared with 24% of the deaths In the other worker* of the 1 same age, 17% of the deaths In other local men, and 14% In the 1 Registrar General's Tables, Of men with more than 10 yr In the rayon Indistry employed in 1 of the factories, those exposed to carbon 1 disulfide had death rates from coronary heart disease between 195D and 1984 2 1/2 times that of the other workers. This evidence of an occupational risk of coronary heart disease from long-term exposure to low concentrations of CSj was strongest in the 1940s and slight In 1958-62; It may relate to wartime plant conditions. Current and prospec tive biochemical and morbidity surveys of exposed workers are now needed. These may also throw light on general issues of atherosclero sis and coronary heart disease.--J. W. S. 43949. ZAEVA, G. N., I. P. ULANOVA (Inst Ind. Hyg. Occup. pfr., Acad. Med, ScL USSR, Moscow, USSR.), and L. A. DUEVA. Materlaly k peresmotru predel'no dopustlmol kontsentratsll formal'de glda v vozdukhc prolzvodstvennykh pomeshchenlL [Materials for a reexamlmtlon of the maximal permissible concentration of formaldehyde in the atr of Industrial establishments, I GIG TR PROF ZADOL 12(7); ie-20. 19C8, [Engl. sum.J--ln a concentration of 5 mg/cublc m. formaldehyde produces general talc and irritative effects and some nonllestatlcni of sensitization. Clinical and hygienic observations made In a number of woodworking and textile Industries demonstrated that on the level of 5 mg/cublc m formaldehyde provoked irritation of the upper respiratory tract and increased the Incidence of disease among workers. The maximal permissible concentration of formaldehyde should be rediced to 0,5 mg/cublc m.--C. M. M. I I , I I 43950. LOPEZ-AREAL DEL AMO. LUIS (SanaL Antltuberc. tafanL, Bilbao, Spain.), and ISAAC FERNANDEZ MARTIN GRANIZO. Neumoeonto*Is seudotumoral por talco y caolUL [Pseudotumoral pneumoconio sis by talc and kaolin, 1 ENFERM TORAX 17(67): 3611-410. OJuA 196U[recd. luoyj.--A pneumoconiosis In a 64 yr old rubber worker <* discovered after he had worked In ths rubber Indistry for 10 yr. Radiological nanlfestatlonx included pleural thickening; the d|Ar*f* 113968-113680 TOXICOLOGY [VoL SI] Hill 113968. PALK3N, V. N. (Med. Inst., Novosibirsk, USSR.) O nrsprtsiftrhrsklkh pncvmonfyakh pri siUkozc. [Nonspecific pneumonia accompanying silicosis.[ GIG TR PROF ZADOL 13(2): bU-UU. I9C9. --Observations ol 2!! patients suffering (ram silicosis and non specific pneumonia revealed that the course and outcome of nonspecific pneumonia In such cases Is highly dependent on the condition of the bronchial tree. In cases of chronic deforming bronchitis, the pneu monia Is protracted and results In the formation of large foci of fibrosis In the silicotic lung. Chronic deforming bronchitis vas.chtcfly ob served In patients who had long ceased to have contact with mineral dust.--A. M. H. 113969. KHADZtllEVA, E. D. (Inst. Ind. llyg. Occup. DIs., Acad. Med. Sci. USSR, Moscow, USSR.) Vllyanic kaprolaktama na prolxvo- dilcl* nuyu funktslyu belykh krys. [Effect of caprolactam on the reproductive function of white rats. | GIG SANIT Zb-ZB."1969. [Lnf.l. sum. |--The etfecl oi caprolactam was studied on the reproductive functions ol albino rats. A dynamic Inhalation poisoning of 107 albino female rats after their Impregnation with caprolactam at different concentrations proved (his substance to affect the conception, the multiplication, the fertility, the course of pregnancy, and the Intra uterine development of the fetus in experimental animals. --L. L. 113970. IZRAEL'SON, Z. 1., (Editor.] Toksikologlyanovykb khimichesklkh veshchcstv, vnedryaemykh v rezlnovuyu 1 shinnuyu promyshlcnnost'. [The toxicology ol new chemicals being introduced Into the rubber and tire industries. I 23Vp. Illus. Meditslna; Moscow, iSWTPrrSZ kopecIts. Iron.: "ftEF ZH OTD VYP FARMAKOL KHIMIO- TER SREDSTVA TOKSIKOL, 1969, No. f.54.886. 113971. KUL1NSKAYA, I. L. (Dep. tad. Hyg., Kharkov Inst. Postgrad Med., Kharkov, USSR.) Nekotorye izmeneniya medlatornogo obmena pri ostrom I khronteheskom otravlcnll serouglerodom. [Some changes of acetylcholine metabolism In acute and chronic poisoning with carbon disulfide. [ GIG SANIT ~34(1): 28-33. 1969. [ Engl, sum. j--in chronic intoxication with CS2 at a concentration of 10 mg/m* certain periodical changes were noted In the cholinergic system of the blood and the acetylcholine content norepinephrine. After chronic intoxication for a period of 11 1/2 mo, a fall of acetylcholine concen tration was noted in the cerebrum, the liver, the kidneys and the spleen. A certain tendency to decrease the acetylcholinesterase activity in the spleen was also noted. The norepinephrine content in the cerebrum and the heart and the epinephrine content in the adrenal glands presented no significant changes. Norepinephrine was discovered in the adrenal glands in some of the rabbits. After acute poisoning with CS2 (12, 500 mg/m2) for 2 hr. the acetylcholinesterase activity decreased in the blood and increased In the cerebrum. The concen tration of acetylcholine in the spleen dlminlahed. Acute CSg poisoning brought about a pronounced fall of calacholamine content in the cere brum, the heart and the adrenal glands. More pronounced shifts of the cholinergic system developed In chronic intoxication and In the sympathico-adrenal system in acute poisoning. The acetylcholine system is a sensitive test for detecting functional changea in the action of noxious industrial factors of small Intensity. --C. M. M. 113972. BARSEGYAN, G. B. (Dep. Ind. Hyg., Yerevan Med. Inst., Yerevan, USSR.) Predel* no dopustimaya kontsentrataiya 1,3-dlkhlorbutena-2 v vozdukhe proizvodstvennykh pomeshchenli. [Maximum permissible concentrations of 1, 3-dlchlorobutene-2 in the air ol inSust'irTal premises. | ZH EKSP KLIN MED 9(6): 66-72. Studies conducted on white mice, rats, rabbits and humans showed that the concentration of this compound is 0.01 mg/l in a chronic experi ment. The recommended permissible concentration for working estab lishments is 0.001 mg/l.--S. T. 113973. DOSKIN, V. A. (Dep. Hyg. Child. Adolescents, 1. M, Sechenov 1st Moseow Med. Inst., Moscow, USSR.) O chuvstvttel noati organizma podrostkov 1 yunoshet k promyshlennym yadam. [Sensitivity of iikilturtitiH and youths to Industrial poisons. [ GIG SANIT M~103. [DAS'--Tne uvatlnliln liti-ruturo on tilt, rflnrl of Industrial toxic nubstanres on growing uikilrscrnts and yuuilin Is rovluwed. --J, 8. 113974. ALEKPEROV, I. I., V. G. KNADENGOF, and M. I. VINOKUROVA. (E. M. Efcndl-Zad Inst. Ind. Hyg., Occup. DIs., Baku, USSR.) Funktaional' noc soatoyanle serdechno-sosudlstoi alstcmy u rabotayushchikh s uglcvodorodami netti. [Functional state of the cardiovascular system of persons who work with petroleum hydrocar bons J GIG TK PROF ZAliOL 13(2): -(9-50. 19C9. --Clinical studies of 50 petroleum industry workers (20 to 40 yr of age), who worked under conditions of direct contact with petroleum products, were contrasted with data on 20 institutional workers of the same age distribution to detect functional shifts in the cardiovascular system under the influence of exposure to such products as styrene, divtnyl, ethylbenzene, etc. ECG changes were basically expressed In small dystrophic alterations of (he myocardium resulting In a slightly Impaired myocardial con tractile function. Oscillographic study of the vascular tonus revealed a prevalence of cases with a reduced mean arterial pressure, a con dition typical for persons frequently exposed to hydrocarbons. The oscillographic Index, which reflects the effects of autonomic regulation. was asymmetric. Caplllaroseopy revealed static-atonic functional reactions with impaired resistance. --A. M. II. 113975, PENKOVICIl; A. A. (Inst. Ind. Hyg. Occup. DIs., Gor'ki, USSR.) K otsenke lzmcnenll v malom krugc krovoobrashchcnlya u bol' nykh nvlevyml zabolcvantyaml legikh. [Assessment of changes In pulmonary circulation in pneumoconlosln paticntsT] GIG Tlk PKQF ZADOL 13(5): 40-43/ lltfi'J.--The character, frequency and ex pressivity of shifls caused by changes in pulmonary circulation in patients with occupational bronchitis and pneumoconiosis were evaluated On the basis of ECG, polycardiography and pulmonary rheography data. Morphological deviations and functional disturbances In the apparatus of external respiration arc significant in the development of changes in pulmonary circulation in pneumoconiosis patients. The use of these methods sometimes reveals even at early stages of pulmonary In sufficiency, a number of functional shifts In pulmonary circulation, which can be regarded as the result of an increase of pulmonary arterial resistance. --J. S. ( ^-- I I _ 11397(0 VAZ1N, A. N., and E. L PLOKHOVA. (Inst. bid. Hyg., Occup. Die., Gorki, USSR.) Dinamika soderzhanlya adrcnallnopodobnykh veshchcstv v krovl krollkov pri khronlcheskom vozdeistvll parov vlnllkhlorida. [Dynamic changes in eplncphrlne-llke substances in rabbit blood following chronic exposure to Vinyl chloride famgrr--GIG 'CR-pROF ~gre0L 13(6): 4^47.1868.~Chrwgc ' action of vinyl chloride fumes causes profound functional changes In the anterior and, most particularly, in the posterior nuclei of the hypothalamus. This leads to hyperadrenaliem, resulting in a patho logical toxic iflgloneurosls.--R. B. C. 113977. VOL'FOVSKAYA, R. N., and L D. MAKULOVA. (Inst. Ind. Hyg. Occup. Die., Acad. Med, Set., USSR, Moscow, USSR.) K voprosu o techenll anglodlstonlcheskikh sostoyanil s arterlal'noi glpertoniel tokslcheskoi etlologll, [Course of ingjodvstonlc conditions with arterial hypertension of toxic etiology. | GIG TR PROF ZABOL 12(11): 12-15. Illus. 1966. [EngL sum. j--Observallcns were made for as ltxig as 6 -10 yr or mare or 69 motor car drivers up to the age eg 40 (65 males and 4 females) with a long record of chronic CO poisoning (36 persons) and chronic poisoning with ethylated gasoline end CO (31 persons). Note was taken of the intensity of the anglodystonlc syndrome, such as encephaila, vertigo, diencephalic crises and manifestations of coronary spasms. As well as Increasing organic symptoms which were apparent in 15 cases, 25 persons developed hypertensive disease within the observation period (mostly at the age of 40-45), Hypertensive disease ordinarily proceeded against the background of residual manlfestatio'-y or remote consequences of the sustained poisoning, being distinguished by a specific evolution. Pro nounced vegetative symptoms, diencephalic crises, syncopes, short lapses of consciousness endocrine disturbances in association with sn trganic brain lesion or affection of the peripheral nervous system were noted. The tGc engiodystonlc syndrome as well as arterial hypertension furthered the development of hypertensive disease. --L.M.L. t t iI t V 1 1 113976. SEDOV, A. V,, and A. N. MAZIN. (Inst. Biophye., Min. Health USSR, Moseow, USSR.) K voprosu o normlrovanli vrednykh prlmesel vo vdykhaemykh gazovykh smesyakh. [Problem of standardi zation of noxious admixtures in Inhaled gaseous mixtures. I GIG SANlt 33(2): 82-94. 1968.--Data on gaseous toxic substances (CO2, CO, NH3) in exhaled air compiled from their maximum permissible con centrations in the air of industrial establishments show that their maximum permissible cmcentratlons do nrt depend on their concentra tions in air exhaled by humans.--L. K. R. 113979. VENGERSKAYA, Ktu Ya., and N. M. DEMIDENKO. (Tash kent Med. Inst., USSR.) Metod opredelenlya pentakhlorfenola v vozdukhe pri uel'skakhozyaitvennykh rabetakh. [Method for deter mining pcntachlorophcnol in thn air during agricultural workTl CTG SANIT 33(2): 57-tiH, lDdri,'--This melliod confiiMrd irf using liquid meiltn (a 0.BT sulutlnn nf sodium csrlinnnin, 0.01 and 0.001 N snnillins of sodium hydrmiilp, acetone and ethyl alcohol, aa well as allies gel) and certain filters. The reaction was verified with various agents. The best effect was obtained with the reaction with plramldon (dlmethylamlnoantlpyrine). The sensitivity of the method le 0,5 pg. --L.K.H. 113980. MATYSYAK, V. G. O vliyanll parov benzlna na menstrual'nuyu 1 detorodnuyu funktsll 1 glnekologlcheskuyu zabolevaemost' rabffnlts rezinovoi promyahlennostl. [The e(fect of gasoline vapors on the menstrual and childbearing functions and the gynccoioocaimorbidity of femaie workers at a synthetic rubber factory. I Tk AZtiti! tJAucH1SSLED INST GIG TR MOV ZADOL--2: "74-80. 1968. Translated from REF ZH OTD VYP FARMAKOL KIOMIOTER SREDSTVA TOKSI KOL, 1969, No. 11.54.1199.--Examinations were made cf 3017 female workers [19-40 yrold| In ths synthetic rubber Industry, whose length of service in the industry was 6-16 yr. There were disturbances of the menstrual cycle and menopausal disorders. A decrease In the average number if pregnancies, and Increase In the frequency of spontaneous abortions and premature births. In the number of Infant* born dead; and t r( i 1. t \ 1 t ! r t 1 1 * c c : 1 t 1 I \ f r / a C / v l ra 1 i. ia r r c P t* B P * T 2 l S c P It h o V P c t t T It <* K R&S 131235 nm |3-f39 11970] TOXICOLOGY 136676-136689 R&S 131236 INDUSTRIAL TOXICOLOGY $r* >l*o: Public Health - Occup.itlon.il Health, Radiation Health i 136676. MOSKQWITZ, nOnERT L. <185 Lexington Ave., Paaaalc, USA.) Tale pnoumoroniosls: A treated rase. CHEST 58(1)? Hi. Illus. 19V0,--me ease ol a young woman with pneumoconiosis to chronic aerosol Inhalation is reported. It was evident from both X-rav film* and biopsy studies that the limp showed both prsnulotnatous (carlvl and tibrntle (late) rhanprs. The patient showed marked subjective as writ as objective evidence ot Improvement after treatment with prednisone. t 136677. MORSE, KENNETH M. (US. Steel Cnrp., Pltlsburph, pa., USA.) Dust ronlrol praetires in the bituminous coal mining industry. AM bn IND HYG ASS .1 31(2): 160-169. Illus. 1970.-- The nee? for improved dust control in bituminous coal mlninp is reco(3it7ed bv the industry and considerable effort in this direction Is hemp aiipllcd. The peneral methods of dust suppression consist of wet rutting and water sprays at dust sources in handling the coal to prevent dust generation; high pressure sprays on (he mlninp machine to reduce airborne dust; wet drilling; the use of dust collectors on roof bolting drills; face ventilation by the line brattice or exhaust tubing and auxiliary lan method; limiting a single machine In each spilt ol air and the use of filter and air supplied respiratory equipment. This paper dismisses each ol these control measures with emphasis on preventing the generation of dust and the application of (mod face ventilation praclice. 136678. ALIDAEV, T. S. Reflektomye reaktxtl cheloveka prl vdvkhanti mikrokontsentratsii tsiklogeksana i smesi ego s benzolom. (The human reflex reactions under inhalation ol mlcroconccntratlons of evcloliexane and its mixture with benzene.| tR UHM NAUCHISSLED IN^T GIG PH6E2ABOL 4; 26CI-J65. 1968. Translated from REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSIKOL, 1969, No. 10.54.883.--Studies were made of the level of the reflex action ol cyclohexane (I), benzene (ID and their mixture on the olfactory sense and on the development of a conditioned electrocortieal reflex. The threshold of the olfactory perception of I was 1.8 mg/m-*, that of It, 2.9. The subthreshold of olfactory perception was 1.4 and 2.5, respectively. For the mixture of t and 11, action of the simple summational type was established. The perceptible concentration was equal to the threshold concentration, the undetectable concentration was 0.8 times the threshold. According to the EEG test, the threshold of 1 was also 1,8 mg''m3. A subthreshold concentration of I of 1.4 tu^^ was suggested as the maximum allowable concentration. When occur in the air together, their concentration should not exceed tn^Pnividual maximum allowable concentrations. There is a biblio graphy with 15 references.--S. T. 136679. FRANCO, P. (1st. lg.. Untv. Roma, Rome, Italy.) Vn episodto di awelcnamento colletttvo da gas tossicl a bordo dl una nave mercantile. I Gas poisoning aboard a merchant ship. 1 ANN SANITA PUBB 29(2): 409-4io. 1968. |Fr., ngl. and Span, sum.]--The occurrence of several cases of pas poisoning (including a fatal one) caused by hydrogen sulfide and arsenic hydride aboard a merchant ship carrying siliceous iron is described. The necessary measures to be adopted ior the protection ot crews dealing with such dangerous material are outlined.--J. W. S. 136630. SHALAMBERIDZE, O. P., 0. I. DEDABR1SHVIU, R. I. EVDOKIMOVA, Ts. A. NAD1RADZE, and T. A. NATADZE. Vilyanie proizvodstvennykh vybrosov khunkombinata s prelmushchestvennym soderzhamem semistogo gaza 1 dvuokisi azota na nekotorye pokazateli sostoyaniya zdorov' ya i flzicheskogo razvttiya detcl. (The effect of industrial effluents from a chemical factory containing mostly sulfur .dioxide and nitrogen peroxide on some variables of the hcaltn and physi cal development of children. | SB TlTNAUCll-ISfelED INST SANIT GiC (jftL'Z SSIl 6; 399-364. lflfiB. Trannlaird from REF 7,11 OTD VYP FAHMAKOI. KIIIMIfm:it Sltl lWTVA TfiK.SIKOI^ 1970, No. 1.54.1530. -A Miilv w.tH niadr nf Uh* jjlivMc.il i1iivi.|m|,iiii.)i( null lii*ullh nf 448 rliiliimi aged 5 tu 6 vr who lived wtlliln a rmlliin nf I km from n rln-mn.il l.u t.irv prndm-tng N fertilizer and caprolactam materials. The ronrrntration nf NOj, SOj, and CO exceeded the maximum allowable concentrations up to 2 km from the chemical factory. Controls, con sisted of 423 children living 6 km from the factory. In the children of the control group all the variables of their physical development were higher than in the children from the area with the contaminated atmo sphere, In the Litter children observations were made more frequently oi an increase in the size ol the peripheral lymph nodes (by 10'x) and the tonsils (by 16V) --S. T, 136681, YOSH1DA, KYOKO (Sumitomo Hoep., Osaka, Jap.I YOSH1HIKO KOMOIKE, SHOOKO NAGAM1NE, and SHUN* ICH1 HOR1GUCHI, ICoproporphyrln in the urine of lead handlers: I. SuppleWfnMwrfport on determination. I s'UMITOMb lillLL (NO HEALTH L I968|ret-d. 19G9J. (In Jap. with Engl, sum.]--While "fb'^^ffeproporphyrln which provides a useful Index for an early diagnosis of latent industrial lead poisoning was being determined in lead handlers, Its chronological decay was studied experimentally. Urinary roproporphyrln was easily dissolved when exposed to direct sunlight. In 24 hr fluorescence completely disappeared. When the urine was stored In a cold, dark place, it showed a considerable decay and increase in 4- 5 days. Determination of urinary roproporphyrln should be done not later than the day oiler obtaining the urine speci mens. if kept in a cold, dark place, those specimens should not be stored longer than 3 davs.--J. W, S. ^ 138682. HORIGUCin, SHUNMCm. (Osaka City Unlv. Med. Seh., Osaka, Jap.) |A review nn Ihe recent 10 years llteralures of lolucne poisoning. I SUMiTOMG DULL IND IIFAlI II T9GB|rrcd. 1363], |in Jap. with Engl, sum.]--Since the 1st laial case of benzene poisoning was found in 1957 among thrjrinyl chloride sandal manufacturers in Osaka, the Incidence has~bccn'on the increase. An attempt was made to employ toluene which is similar to and less toxic than benzene, ns a substitute for benzene. However, studies have been more centered on benzene than toluene, II Is only recently that toluene has been investigated. The literature on toluene poisoning at home and abroad for the past 10 yr or so is listed. --J. W. S. 136683. IL'IN, B. 1,, L. I. KOGAN, and N. V. BUZULUT5KI1. Gnoinichkovye zabolevanlya u Ilts rabotayushehlkh s goryuche-smazochnyml veshchestvaml. [Abscesslike diseases ot persons who work with fuels and lubricants.) VOfeNNO-MfeD ZH 9. 69. 1969.--Ob servations oi 81 persons with different forms of pyodcrmalitis (folli culitis, furuneull, furunculosis, hldradenitls) are presented. Pro phylactic measures for treating the skin alter contamination with fuel products such as gasoline, diesel fuels, and lubricants, which were established to be the initial causes of the conditions, are listed (use . of lanolin base cleaning pastes, rinsing or rubbing the skin with alco hol, glycerine and chloramine solution).--A. M. H. 136884. RUSSKIKH, V. A., and N. S. LASHCHENKO. (Inst. Ind. Hyg. Occup. Dis,, Gorki, USSR.) K voprosu ob ozdorovlenii uslovtl truda v protzvodstve granozana. (Sanitation of work conditions in Ceresan industry. 1 GIG TR PROF ZABOL 13(10): ll-14. 1969. [Engl. sum. J--Data derived from hygienic and clinical investigation carried out over a period of many years and characterizing the effective ness of health measures are presented. Recommendations for further Improvement of work conditions in the Industry producing Ceresan, ethylmereuric chloride seed fungicide, are given.--C. M. M. 136685. BE HINT, F., P. PELLEGRINI, and V. COLAMU5SI. (1st. Pafol. Spec, Med., Univ., Ferrara, Italy.) Elimlnszlone urinaria di piombo e coproporfirine durante 11 procedlmento dl lavorazione del piombo tetraetile e tetrametile in ralfinerie di petrol!. (Urinary elimination ol lead and coproporphyrins when working with tetraethyl and tetramethyi lead in oil refineries. I LaVORO UMANO 2i(li/12); 49!)-5ll. 196^( reed, 19701, Ifind. sum. ]--A study on urinary lead and coproporphyrins in some workers of an oil refinery before work, immediately after work and 24-48 hr after work was carried out. The amount of lead found in the urine was within normal limits when the Individual protecting equipment was perfect (an increase in the urinary coproporphyrin was observed in some cases) even if the concentration of lead (which varies remarkably according to ventilation) is higher thanm.a.c. [maximum allowable concentration],--J. W. S. 136686. STAMM, E., andE. KERSTEN. (Inst, Arbeitshyg., Univ., Rostock, EastGer.) Untersuchungen zur Gefaehrdungsmoeglichkiet der Maschinenpersonale durch Schiffsdiesel-abgase. (Evaluation of exposure of engine room personnel to diesel exhaust-gases of a ship. 1 vfeRKEhRSfeb GRENZfiETfi i'TfJT: Tfie-ilft", llGs. "iM6. [fengi., Fr. and Russ, sum.]--Toxicological relevance and concentrations of CO, CO2, hydrocarbons, polycyclic compounds, aldehydes, nitrous oxides, ammonia, and soot and oil smoke in Diesel exhaust gases are dis cussed; a plan for sampling and analyzing with regard to chemical deter mination In the air of the engineroom of a ship is presented. Results of measurement show a temporary exreeding of the maximum admissible value only for hydrorurbunn, --J, W. S. 130687. GASPARYAN, E. 1. Reaktsiya morfologichcskoi dlssotsiaisll krovi u rabochtkh, zanyatykh v protzvodstve khloroprenovogo kauchuka. [Morphological dissociation reaction of the blood m workers producing chtoroprene rubber. | SB NAUCH TR NAUtH-ISSLED INST " tfeMATOL PtlRE t.IV KHOVI ARM SSR 11/12. 361-364. 1988; (Arm. sum,] From: REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSIKOL, 1969, No. 11.54.964. 138686. VON UBISCH, HANS, The concentrations of sulphur dioxide Inside 1 modern office building. ftoRb HVC TlbSKR 6l(l): 25-14. Ulus! 1970.--It Is shown that the straight-forward ventilation system of a large office building reduces the SO, concentration of the ambient city air to about 601?. visitors from the street, however, appear to carry considerable quantities of air through revolving doors. By proper design of a building, it should thus be possible to improve Us air quality considerably, --J, W. 5. 46266-46296 TOXICOLOGY |Vol. 52(8)) 4702 These rats Inst their toxicity symptoms and gained normal weight. --J. W. S. 46286. SEYAMA, 1SSE1. ntlrnnhlma Untv. Med. Sch., Hiroshima, Jap.) Efleet of grayanoinxln 1 on the electrical properties al rat skeletal musrlc llhrrs. .IAT .1 I'lIVStOL toUf: 3m-38j. tllus. 19L/0.--Etleel ol gravanotnxln 1 on the soleus and extensor digllorum longus muscles of rats was studied by the electrophyslologieal methods. Grayanotoxln 1 has an Inhibitory ellect on the Initiation of action poten tials of fibers of both muscles. This toxin causes a gradual decrease of the resting potential and an elevation of the critical firing level. As decrease In resting potential Induced by this toxin was always associated with reduction of the effective membrane resistance and these phenomena were not observed upon withdrawal of Na from the medium, depolarization of the membrane in the toxic solution Is con sidered to be due to Increased permeability of the membrane to Na ions.--J. W, S, 46287. ROTH, L., P. TVRCANU, O. MOISE, P. CARTIANU, V. SEROAN, and GH. MOISE. (Clin. II. Med., Inst. Med., Timisoara, Rum.) Contrtbutll la stulut slndromulul hemoraglc 5n benzenlsm. fhe study of hemorrhagic syndrome In benzene poisoning.) IG1ENA i 9<-i): 221J-235. 1970. |fr., Ger., Engl, and Russ. sum. j--Hemostasis determined in 20 patients with chronic benzene poisoning (8 with hemor rhagic syndrome and 12 without hemorrhages) showed periodic hypocoagulability, more accentuated in the patients with hemorrhages, due to insufficient thromboplastinogcnesis. Comparative prothrombin con sumption in the 2 groups showed statistically significant differences, the.values being almost normal in the non-hemorrhaglc cases. The same difference was observed with regard to vascular fragility. In chronic benzene poisoning, the hemorrhagic syndrome appears to be due especially to thrombocytopcnia-thrombocytopathy and to capillary fragility. The situation is sometimes aggravated by accumulation and by the subacute fibrinolysis. The dyscrasla defects observed are likewise correlated with the presence of paraproteins; it Is assumed that in chronic benzene poisoning paraproteins may Interfere with the hemostasis-coagulation mechanisms, both by neutralization of certain platelet functions and by their capillarotoxic function.--J. W. S. 46288. AKIYAMA, AKIO. (Dep. Biol., Toho Unlv., Chiba, Jap.) Acute toxicity of two organic mercury compounds to the leleost. Orvzlas iatlpes, in different stages of development. BULL JAP SOC SCI FISH 36(6): 563-57(1. Illus. 1970.--The differential susceptibility of eggs, developing embryos, fry and adults of a cypridont fish, O. talipes, were studied on the basis of the 24 hr Median Tolerance Limit [TLm] to the organic mercury compounds, phenylmercurlc acetate [PMA] and metoxyethylmercuric chloride. The aliphatic organic mercury, metoxyethylmercuric chloride was less toxic than the aromatic organic mer cury, phenylmercurlc acetate, Tor metoxyethylmercuric chloride, 24 hr TLm for eggs, fry and adults was 0.50-1.30 ppm, 1.48 ppm and 1,74 ppm respectively, while for phenylmercurlc acetate, 0.18-0.26 ppm, 0.03 ppm and (L2l ppm respectively. To all toxicants applied, adult fish were more tolerant than fry, but eggs in the solution of PMA were the most resistant. In developing embryos, 24 hr TLm for the organic mercury compounds gradually Increased through the early stage, passed through a maximum In the medium phase [5-day-oldj, and finally fell off in (he later phase. With the growth of the fish, 24 hr TLm increased logarithmically.--J. W. S. 46289. JACOBS, RAE R., BRYN T. WILLIAMS, and WORTHINGTON C. SCHENK, Jr. (Veterans Admin. Hosp., Buffalo, N. Y., USA.) Cardiac and svstemlc toxicity of hyperbaric oxygen. J THORAC CAEbiOVAsc SOftC'' 55M): 555'-K7. hfiST iS70r~Dogs subjected to 4 atm of 02 for 30 min showed a fall in cardiac output, cardiac power, systemic O2 consumption, and cardiac efficiency. Although (he amount of O2 required for metabolism was offered to the tissues with a reduc tion in cardiac work, the tissues were not able to utilize the Og. The mode of action of the systemic and cardiac O2 toxicity la not evident In thte study.--J. W. S. 48290. nnOWN, STUART I. (N. Y. Honp.-Cornoll Unlv. Med. Cent., New York, N. Y., USA.), CAROL A. WELLER, and SIIINOBU AKIYA. Pathogenesis of ulcers of Hit* alkali-burned cornea, ARCH OPI1THALMOL B3I2): 205-208. tllus. 1970.--Intraiamctlar Injections of small quantities of harvested collagcnase from the ulcerated tissues of alkaliburned corneas produce full thlckneBS ulcers In intact-alkali-burned rneas (rabbits). This Is (he final proof that the enzyme Is responsible r the ulcere of the alkali-burned cornea. The enzyme Is produced the epithelium and cellular elements of the stroma. A scheme for e pathogenesis of the alkali-burned corneal ulcers Is presented and expanded to implicate the enzyme in many clinical destructive condtXU.--J. W. S. 40231. WOOLLEY, DOROTHY E. Rnd. Med. and Surg., P.O. Box 16, Miami, Fla., USA.) Effects of acute and chronic exposure to DDT y] of I>DT-drue Interactions on experimental seizure responses, (I) MEtTSUItC ~3TO): 361-365. tICs, 1970.--The eHect~of PDT id of drugs were Investigated In rats, measuring the duration of the liases of the maslmal eliTtroshnrk seizures (MES). The alterations produced by DDT were unexpected: although the dosrs administered usually produce hvpcrrxcllatlon and tremor, the effects were similar to those produced by pentobarbital, and opposite to those of some excitant drugs. The results show that the rhrnnlc exposure of the rat to levels of DDT as low as 5 ppm can produce effects detectable with the MES. Also, DDT-drug Interactions often arc unexpected,--.!, w. s, t 46292. MARUYAMA, YOSHIAKI, KAZUIHDE KOM1YA, and TERL'O MANRI. (At. Res. Lab., Musashl Inst. Tcchnol., Kawasaki, Honshu, Jap.) Determination of copper, arsenic and mercury tn cigarettes hv ncutron~aciivation analysts. RAUIOIsOtOI'KS lbtii: 25U-HW. l'J/Q. --U lias berome an important task to determine the levels of pesticides In biological materials. Radloartivation analysis is very useful for this purpose. In (his study, the Cu, As and fig contents of cigarettes were determined by neutron activation analysis. Alter decomposition of the Irradiated samples with a mixture of nltrtc and sulfuric acids, Hg and Aa were separated by distillation, and precipitated as sulfides. Cu was precipitated also as sulfide. The determination of these ele ments was based on the detection of the gamma-rays of 64Cu, 76^1 and 191Hg formed In the (n,gamma) reactions.--J. W. S. INDUSTRIAL TOXICOLOGY See also: Public Health - Occupational Health, Radiation Health t 46293. COHEN, SEYMOUR I., GEORGE DORION, JOHN R. GOLDSMITH (2151 Berkeley Way, Berkeley, Calif., USA.), and SOLBERT PERMUTT. Carbon monoxide uptake by inspectors at a United States-Mexico border statlon. ARCH ENV1RONHEALTH 22(1): 47-54. Illus. 1371,Coliectlon of explred-air CO aamples was utilized to examine Inspector! on the border to determine if significant Increases in COKb occur. Border Inspectors (28) were categorized as to smoking habits and work shift CO exposures. Employees not actively engaged ui car inspection duties constituted the control group. Following shifts when particularly high ambient CO levels persisted, significant Increases in COHb were noted in both smokers and nonsmokers. Controls did not exhibit signif icant alterations in COHb levels. The hazards of such COHb elevations to exposed individuals are discussed In light of recent evldenct of a lack of threshold for cardiovascular and CNS effects. f 46294? DINMAN, BERTRAM D. (Inst. Environ, and Ind. Health, Unlv. Mich., Ann Arbor, Mich., USA.), WARREN A. COOK, WALTER M. WHITEHOUSE, HAROLD J. MAGNUSON, and THEODORE DITCHECK. Occupational acroosteolvsls: I. An epidemiological studv. ARCH ENVIRON HEALTH 22(1): 61-73. tllus. 1071.--An epidemiological study was performed covering 5,011 employees with 21,510 man-years experience In various phases of vinyl chloride (VC) and polyvinyl chloride (PVC) manufacturing in 32 plants throughout the USA and Canada. The total number of definitive cases of acroosteolysis (AOL) was 25; 16 other individuals were under suspicion. This conditlon-ls clearly associated with.the hand cleaning of polymerlzers. Workers engaged In other phases of VC or PVC manufacturing do not appear to be at risk of developing AOL. The importance of Raynaud's phenom enon as a concomitant of AOL is emphasized. Several statistical approaches for rapid medical survey are suggested. Acroosteolysis appears to be a systemic rather than local disease. Presently, neither the etiological agent nor its portal of entry is known. t 46295. COOK, WARREN A., PAUL M. GIEVER, BERTRAM D. DINMAN (Sch. Pub. Health, Unlv. Mich., Ann Arbor, Mich., USA.), and HAROLD J. MAGNUSON. Occupational acroosteolvsls: H. An Industrial hygiene study. ARCH ENVIRON HEALTH 22(1): 74-82. Illus. 1971.--An industrial hygiene survey was conducted In respect to occupational acroosteolysis (AOL) In 32 plants engaged in produc tion and compounding of polyvinyl chloride. Thu survey was limited to inspection of facilities, interrogation of technical personnel, and statistical analyses. All manufacturing processes and chemicals utilized were explored, A major objective was the Identification of variables in processes and chemicals that were peculiar to those plants affording known canes of AOL. No such processes or chemicals were found. The survey brought to light a number of situations sus pected of relationship to the precUc cause of AOL, some at which require additional exploration. Most positive of these was the finding that essentially all of the persons who developed AOL had served as reactor cleaners using manual methods. T 46296. DODSON, VERNON N., BERTRAM 0. DINMAN (Inst. Environ, and Ind. Health, Unlv, Mich., Ann Arbor, Mich., USA.), WALTER M. WHITEHOUSE, AHMED N. M. NASR, and HAROLD J. MAGNUSON. Occupational acroosteolysis: HI. A clinical study. ARCH ENVIRON HEALTH 22(l): 83-91. tllus. 1971.--Four subject* with acroosteolysis were studied clinically. All had osteolytic lesions, especially In the distal phalanges ol the hands, and Raynaud's phenom enon. All had worked aa polyvinyl chloride reactor-vessel cleaners, with hand scraping being the common mode of operation. Raynaud's phenomenon anteceded osteolytic lesions. One of the eubjects was In negative Ca and P balance. Plethyamographlc abnormalities were present in 3. Esophageal motility was normal.. Scintiscans (4 the le m r M In a: Tt th' pn m. tl di pn ov co; tlo CO! wh Sic gr. not cor t< US. AC Ex: bio ath sec Wai myi di5: in t. deir wit) eric bull The com t 4( Luc and err to til In Ir tser. to si dose 1st < on a thes. i grou . asse t 46: G. C labor I --Th find:. 6,7-e naphzer y Thre Elghaurc blood abscr Seve: ceas. later tion r initu days. expo; than . 46Jand 1 chic: olisn 5337' inter prut hyt*v I R&S 131237 4704 lApr. IS. M>71| TOXICOLOGY 46319-4632V , cleaning, hydraulic wash-out) and hygienic (anil-dual respirators, proiccilvc pastes) measures were recommended. Introduction ol such measures at a number o( electric power stations helped to drastically reduce the concentration of fuel and cinder dust In the atmosphere of wnirifkcnilscs and to do awav with acute and chronic occupational dl^B.--C. M. M. 46319. PAVIOVA, L. P. (M. M. Efendl-zadr Inst. lnd. live. Occup. Dis., Summit. USSR.) Materlaly k obnsnovanlvu predel'no dopusllmoi kontscntralsli dllr.opropllbcnr.nloy vor.dukhe prolzvodstrcnmkh ponteshrhenil. I Materials (or establishing Ihe maximum permissible conrent ration of diiyopropyl benzenes In "the air Ot imtu-lrial premises,| GIG Tit 1'HOK /.AHO17 1412): 4143, Ulus. 11170. |KngT. sum.|--The comparative toxicity of m- and pPIPB |diisopropvllienzrnes| was studied at lethal, toxic and thresh old concentrations and dosages. DIPD are virtually devoid of cumulatlrecapabilitv. Chronic action of their lumcs at a concentration ol 1 mg I produced CNS inhibition, disturbances of the anti toxic-synthetic and protein-forming function of the liver and sharply pronounced primary leukocytosis with subsequent tendency towards leukopenia. Concentration of 0.2 mg I was the threshold value In a chronic test. Dim (0.06 mg 1) was (he recommended maximum permissible concentration (or. the atmosphere around work places. . --C.M.M. 46320. SIMPSON, G. R. fDiv. Occup. Health. Lidcombe,' N. S. W., Aust.) Exposure to dust in the cotion-garnrtting industry. MED J AUST 57-1(23); 1151-1152. 1970.--Six cotlon-garncttlng plants were examined and cotton-dust concentrations of 6 to 21 mg'cu m were recorded in the In-plant atmospheric breathing-zone. Tests of lung (unction of the operators showed an over-all average fall of forced expiratory volume [FEVj | of 0.12 1. In more dusty areas, an average fall in FEVj of 0.28 l was recorded. At dust concentra tions in the vicinity of 6 mg ' cu m, little change in FEVj occurred. As the air-borne dust was not entirely raw cotton, a figure of 5 mg cu m of cotton dust in air is suggested as a tentative thresh old value for this type of work. The use of exhaust ventilation is recommended to reduce Ihe concentration of cotton dust in air. -C. M. M, 46321. MEL'NIKOVA, M. M,, I. S. IVANOVA, and B. A. YAMPOL'SKAYA. (Cent. Inst. Postgrad. Med., Moscow, USSR.) K klinike khronicheskoi intoksikatsii okis'yu ugleroda. [Clinical picture In chronic carbon monoxide poisoning,I GIG TR PROF ZABOL 14(9): 23-2j^J97Q. |Engl. sum.|--Results of an examination of 286 wor^^^ngagod in servicing taxi-fleet garages of the city of M whose occupational activities involved their being exposed to the effect of elevated concentrations of CO exhaust gas are pre sented. A high incidence of functional disorders implicating the CNS, appearing in conjunction with vegetative-vascular dysfunction, hyper tensive reactions and ECG signs of focal and diffuse myocardial changes, was noted: A high carboxy Hb level in these persons con firmed the etiological role played by CO In the development of these changes.--C. M. M. 46322. BLAGODATIN, V. M., I. A. GOLOVA, N. K. BLAGODATKINA, E. P. RUMYANTSEVA, L. A. GORYACHEVA, N. K, ALIEVA, and E. a. GRONSBERG. (Inst. Ind. Hyg. Occup. Dis., Gorki, USSR.) Voprosy gigienv truda i profpatoiogii v proizvodstve organicheskogo stekla. [Issues of industrial hygiene and occupational pathology in he manufacture of organic glass.| GIG TR PROF ZABOL 14(8): 11-14. 1970. | Engi. sum, Four factories manufacturing organic Slass fpoiym "thy(acrylate) destined for different purposes were reviewed. A feature common to all of them was air pollution in work premises with methybnrthacrvlate (MMA) ftun-s. Its concentra tor! varied within a wide range. MMA produced an adverse effect at the health of the workers, manifesting itself in the development jf chronic occupational poisoning.--C. M. M. 46323. GI.iKSIITFIN, M. D, Sla/hevye (umbennosti artcrlal'nngo onusa u ral,4a\ushchlkh s mnInM-rnvnlvntl nrftvanil. | I.rngih-w-mri' ri-hiti'd leattireH of tlm artenal tonus In persons working tut, |..w-sullu"r'|i''lriileuniT Tit A'ZKfUl NAUCII-I.SSI.kT} INhTTItG m p[(0F 7.AT)0l~T, MT74. I960. From: REF Zlf OTD VYP 1 ARM \KOL KHIMIOTER SREDSTVA TOKSIKOL, 1970, No. 1.54.1315. 46324. KHLEBNIKOVA, M, I., E. V. GLADKOVA, L. T. KURENKO, I. V. PSHENITSYN, and B. M. SHALIN. (Inst. Ind. Hyg. Occup. >is., Gorki, USSR.) Voprosy gigieny truda I sostoyatue zdorov'ya abnchikh v proizvodstve o-ioluidma. [Problems ot Industrial vgtene and health status of workers engaged in Ihe production of Moruidtmq GIG TR i>IT0f ZAltoC 14/8): 7-10.1D70. [Engl, tim,|--Work conditions and health status of workers engaged in the nxiur iion ol o-toludine were studied. The air of work premises ontuMkincreased cnncenirailons of o-toluldtne and o-n-toluene. ',m^^Bers demonstrated dysurtc manifestations. Initial palhowe^Bneratlon* of The urinary bladder mucosa and, in individual estances, bladder papillomaa. These change* and disorders were 1 an occupational nature. Special experimental investigations are needed to determine Ihe extent of ihe hazard caused by each toluidine Isomer In regard to the development ol urinary bladder tumors. --C. M. M. 46325. AGARKOV, F. T., and S.V. AGARKOVA. (A. M. Gorkll Med. Ins!., Donetsk, USSR.) O temperature wriykhaemogo vnrdukha I konditslonlruvushcHel funklsll dvkitaiel'nogo apparaia zdorovykh I bol'nykh pnevmnkontozom shakhlerov. [Temperature of exhaled air and conditioning (unction of the respiratory apparatus In healthy and pneumocoolosls-aftectrd miners.| U'fCT Tit Pltol' ZAHOL 14(2): 31-34. l'J70; |Kngl, sum.|--The expired air temperature was registered In 864 practically healthy and pneumoconiosis-affected misers by an electrothcrmom-lcr provided with a highly sensitive and low-inertia thermistor sensor. This was paralleled by Ihe measurement of vital capacity of the lungs. The data obtained formed a basis for determining reserve conditioning potentialities of the respiratory system. The expired air temperature in practically healthy miners is approximately the same as in normal subjects not engaged in mining, averaging 34.37 + 0.03*C. In pneumoconiosis and its progressive development, the temperature of expired air goes down. This is accompanied by a distinct decrease of reserve conditioning possibilities of the respiratory system. The Intensity with which the conditioning function declines augments as the pro cess of pneumoconiosis progresses In Its development.-*C. M. M. 46326. MARIN, A. M., and A. 0. NAVAKATIKYAN. (Inst. Ind. Hyg, Occup. Dis., Donetsk, USSR.) KUniko-fiziologichcskaya kharaktertstika pylevogo bronkhiia u podzemnvkh rabochlkh ugol'nykh shakht. [CUnlcal-ohyslologlcal characteristics of dust-induced bronchitis in underground coal miners,| GIG TR PROF ZABOL 14(2): 28-31. 1970. |Engl. stun.|--Patients |70| with chrome dustinduced bronchitis of long standing were reported. Transformation into (17.11) and suspected pneumoconiosis (8.61 of cases) were noted alter a lapse of 2-5 yr. In patients with bronchitis exhibiting no signs of pulmonary fibrosis, non-diseased miners and practically healthy individuals with no service record In an atmospheric environ ment of high dustiness the vital capacity of the lungs (VCL), resid ual air -(RA), total lung capacity (TLC), maximum volumetric expiration rate (MVER) and maximum volumetric Inspiration rate (MVTR) were determined. When measured, these indices were contrasted against the due values. A distinct rise of RA and an appre ciably fall of the VLC, MVER and MVIR were recorded in patients suffering from chronic bronchitis. Increased RA figures were registered also in non-diseased miners with long service-record, proving early development of manifestations typical of emphysema and deranged pulmonary ventilation.-*C. M. M. 46327. KHENOXH, E. A, Glgienicheskaya otsenka uslovii truda rabotayushchlkh prl mokrykh protsessakh mekhanicheskol obrabotki izdelil iz stekla I khrystalya, [Hygienic evaluation of the working conditions iii wet machining processes ot glass and crystal wareTI GIG TR PROF ZABOL HU): 45-46. 1970. --Wet processes of machining glass, crystal and quartz ware (grinding, polishing and faceting) are accompanied by consider able release of quartz-containing dust Into the air of the work rooms. Grinding and polishing are done mostly by hand and require appre ciable physical exertion on the part of the workers. The consider able release of dust makes It necessary to equip the grinding and polishing equipment with exhaust fans. The occupations of grinders and polishers should be included among those that are deleterious. These workers must undergo mandatory preliminary and periodic medical examinations.--J, S. ^4632b7 SMIRNOVA, N. A., and N. P. GRAN1X. (Gorki Inst. Ind. Hyg. Occup. Dis., Gorki, USSR.) Ob otdalennykh posledstviyakh professional'nykh ostrykn otravlenil nekotorymi uglevodorodami i licit proizvodnyml. [Long-term side effects of acute occupational poisoning by certain hvdrocaroons and their ScnviittvesT)GIG TR PROF ZAHOL 14(5): 50-51. 1970.--A study nf the side effects of oerupallim.il poisoning in 35 persons (olefins, 0; benzyl, 5; ntelhylene chloride, 3; vinyl chloride. 2; (rlcblornethyleite, B; dlchlororthnne, 6; letrachiororthanc, l; chlorobenzene, 3; polychlorobutane, 1) Is reported. In all cases residual effects in the form of functional disturbances of the CNS, symptoms of sympathetic-sensory polyneuritis or organic dis order of Uie brain were observed. The frequency and degree of expression of these side effects depend upon the severity of intoxi cation suffered, previous CNS diseases and the time of return to work after neurotropic poisoning.--C.P. 46329. ENTERLINE, PHILIP E. (Grad. Sch. Pub. Health, Univ., Pittsburgh, Pa., USA.) Validating thresholds using Industrial records, J OCCUP MEG ill2): IU-3i. Ulus. 1970.-industry Has some fairly accessible records which might be useful in establishing Threshold Limit Values for certain substances. These are employment and exposure records on retired populations and records on mortality in these populations. Data available from theae records meet all the requirements for good epidemiological investi gations, There might even be same advantage in pooling retirement sskschwoee^wj R&S 131238 * 7LOCY (Vnl. 52(211] 12204 1971.--In the development of pulmonary silicosis In rals studies on changes In the trial, cslerlflrd. Irre cholesterol awl phospholipids wit made tn lungs. liver and blood plasma over a period o( 200 days. Total cholesterol. Us tractions and phospholipid content Increased with time tn the limps of silicotic animals. Iltstochcmtcally sudanophlllc materials were observed In the cytoplasm ol pulmonary macrophages. Changes similar to those of lungs were not observed in liver and blood plasma; the Increased lipid content ol lungs during experimental pul monary silicosis may be due to the localized degenerative action ot silica on macrophages. t 122288. MUELLER, W,, and C. HOLZAPFEL. ansi. Arbelfshyg., Univ., Jena. E. Ger.) Uebor die Bczlchung zwischcn Delia-Aminolaevullnsaeure-Ausscheldung lm Marn und Blutblclspicgol bel Arbcllcrn mtt unterschledlicher Blelexposltlon. (The relitIonship between A 1.A In urine and lead In blood In workers with dtllcrcnt lead-exposure.| fNT ARCH ARBEITSMED 2W): 331-337. Uhis. 1971. |Engl. summ.]--In 3 groups ot dillercntly exposed lead-workers the relationship between ALA |gamma-aminolevulinic acid] In urine and Pb tn blood was in vestigated. This relationship is not constant and depends on the kind and intensity of exposure. It Is difficult to establish an acceptable limit value of the ALA-output In urine. Women seem more sensitive to Pbdhan men. 122289. LIVSHITS. O. D. O votmozhnOBtl Izpol* zovanlya mestnykh pektinsoderzhashchlkh pishchcvvkh produklov v profllaktike saturnisms. |The possibility of using local pectin-contain lug food products lor the prophylaxis of lead poisoning.) TR PERM MED INST 82; 154-199. 1970. Translated from REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSIKOL. 1970, No. 10.54.589.--For 4 mo. lead acetate at 50 mg/kg was fed intragastrlcally to 2-mo.-old male rats. Those ot group 1 were maintained on the usual ration and those of group 2 were given the usual ration - 50% raw carrots. By the end of the exposure to pb, the rats of group 1 had developed the symptoms ot chronic Pb poisoning; torpor, disturbances ofnutrition, loss of hair and a re duction in food consumption. During the entire period ol observation all the rats of group 2 remained well, gained weight and had a good appetite. In rats of group 2 the daily diuresis was 9-11 ml. On the 20th -25th day of exposure those of group 1 showed hypouria (3-4 ml). The average weight at the end of the experiment was 154.1 g for group 1 and 192 g for group 2. The kidneys and gastrointestinal tract of the rats ol group 2 excreted 97.5 mg Pb (85" of that taken into the body) and rats of group 1, 60 mg (40%). The prophylactic action of local pectin-containing food products should be studied for use in the thera peutic -prophylactic diet of workers exposed to Pb.--S. T. 122290. LOSKUTOV, N*F,, and N. F. SHUSTVAL'. Izmcncnie elcktrokardlogrammy pod vUyaniem krotononitrila i izokrotono-nitrila. [Changes in the electrocardiogram under the action of crotononttrlle and isocrotononitnlo.l TR KHAR'KOV MED IN^T 81. 135-139. 1969. Translated from REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSIKOL, 1970, No, 8.54.635.--In rats and guinea pigs given a single median lethal dose ol crotononttrlle (I) or isocrotononitrile (II; used in the production of synthetic rubber), the ECG showed a reduction In the voltage of the QRS complex, an Increase in the num ber of heartbeats to 600/min, an upward shift from the baseline of segment ST, and the appearance of a high, pointed T wave (for 3-4 days), in subacute experiments I was given Intragastrlcally to rats at 100 and 50 mg/kg and Q at 17 and 34 mg/kg for 1,5 mo. Guinea pigs were given an aqueous solution of 27 or 55 mg/kg of I to drink (or 2.5 mo. The rats showed an increase in the heart rate, upward displace ment ol the ST segment (Tom the baseline, an Increase in the T2-3 wave to 7-8 mm, a reduction in the QRS voltage, an Increase In the PQ Interval, and. In some of the animals, slnoauricular blockade or blockade of the left branch of the bundle of HU. Changed of this type were also found In guinea pigs. Impairment of the principal functions of the myocardium occurs; the conductivity, excitability, automatism, and contractility, this Is explained by Impairment of the metabolic processes in the myocardium caused by the poisoning. There U a bib liography with 10 references. From the Ukrainian Institute tor the Postgraduate Education of Doctors, Khar'kov, USSR.--S. T. '------ 1 \_122201 ,, BASALAEV, A. V. (Gorki Inst. Ind, llyg. Occup.Dls., Gorki, USSR.) Opyt prlmoncniya krupnokadrovol flyuorografu pri ossledovanit skolcta u rabotayushchtkh v kontakte s ncprcdcl'nymi ugtevodorami etilcnogo ryada (olefinaml) I tkh khiorprotzvodnymt (khlorvlnil, trtkhlore! lien). (Experience with the use of large-frame photofinorography In examining skeletal Imnes ol persons occupationally dealing with unsaturaied hydrocarbons ol the ethylene series (olefins) and Ihclr chlorine rierlvailvoB (vinyl chloride, trlchlorclliylcnc).*] GIG TR PROF ZAt>OL 14(11): 34-37. 1970. [Engl. RUm.|--These examinations re vealed a definite reconstruct ton In the bones; osteosclerosis, osteo porosis, osteolysis and cystic changes. Traumatization of the limbs and prevalence In the clinical poisoning picture of these symptoms R&S 131239 l I w I I iw P f T x } * r- I 1 9 \ r I i i V. X I *m l l l 1 tm 1 I l l f 12205 (Nov. 1, 1071] TOXK suggested lesions of higher vegetative centers, particularly of the hy pothalamic region. These changes may be of a ncurodystrnphic nature, 5 Large-Irame photofluorngraphy may be recommended for roentcenologi cal examinations of (he skeleton (n occupational groups with potential bone pathology.--C. M. M. 122292. AMIROV, R. O.. 1.1. ALEKPEROV, and V. D. pIVOl^Hk K sanllarno-glgienlchesknl kharakterlsllke uslnvli truda rabotai^ffichlkh prl poluchcnlt kataptna (IKIKhP-2). |A sank ary-hygienic characterlzatlon ot Ihc working condition* of persons producing katapln (IKIKhP-2) I-(n-do<lervllien7.vl)-pyrHllnim.f tn AZFHirNAUCH-ISSlEd INST GIG TR PROF ZAflOL 3. 139-143. 1969. From; REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSIKOL. 1970, No. 1.54.1319. 122293. BRAKHINOVA, I. T., and G. V. SAMSONOV. Sravnllel'naya otsenka vllyanlya na organism nltrldov perekhodnykh metallov I nemetzilov. [Comparative study of the effect of transitional metal and nonmctalllc nitrides on the hody.| do TR PROF ZABOL 1-4112); 45-50. 1970) reed. 19711.--In experiments with white rats nitrides of nonmetals including BN. SijN^ and BNC had weakly pronounced fibrogenle activity and caused pncumoconlotlc changes. Metal-Uke nitrides Including TIN, ZrN and NbN in addition caused dystrophy of the liver and epithelium of the renal convoluted tubules. The recommended maximum permissible dose tor nttridrs ol non-metal* and NbN Is 10 mg/m3, for AIN Is 4 mg/m3 and for ZrN Is 5 mg/m3. The toxic ef fects of nitrides corresponded to their electron structure. Their biological activity decreased with the increased possibility of forming S2p-clectron configurations during Interaction with N of non-metals and seml-metals and also d5-configurations with the formation of nitrides of transitional metals.--N. L. G. ihUTi* rutflUVIVfV, >.v..WHni iiju MwwTiutjrd hbuii u khlopkorobov, vyzvannye yadokhlmlkataml, 1 meropriyatiya po lkh profllaktike. (Occupational skin diseases In cotton growers caused by chemical poisons and measures tor their prevention.! GIG TR PROF ZABOL 14(1 ji); 35-37. 1970|recd. 1971].--Dermatitis and eczema occurred In 30 persons out of 32 in direct contact with DDT and hexachloranc. The disturbances were of a seasonal nature. Of 633 cotton growers, the skin was sensitive to the phosphoorganic insecticides methylmercaptophos, octamethyl and butyphos In 42%. The time of development of sensitization to different chemicals yarled and depended on body response, concentration of the chemical, work conditions and the nature of contact.--N. L. O. TALIN. Opyt medlkamentoznoi profllaktiki porazhenil nervnol sl^^a prl intoksikatsli ognestoiklm maslorn "Iwlol'-S". [ExjTiene_iTM|W medical prevention of injury to the nervous system In poisoning witr the fireproof oil ~tviorJ".I GIG Tfo PROf ZA60L 14(15); 3V59. 1970(rccd. 1971].--Persons working without gas masks In the remains of a breakdown at an electric power station were intoxicated by the fumes of ~Ivlol-3", a compound based un trixylenylphosphate, vitamin E, vitamin-Bg and phytln was effective in preventing damage to the nervous system.--N. L. G. 122296. ELlSmSKAYA, R. V. Sostoyanie plodovitosti u zhlvotnykh pri khronicheskom vozdeistvil parov metadizopropllbenzola. (Condition of fecundity In animals subjected to chronic effects of metadlisopropvibenzene fumes.7 GIG TR PROF ZABOL 14(12); 44-46, 1970(reed. 1971J.--White rats (45) with strictly periodic oestral cycles were ex posed to the fumes of metadilsopropylbenzene In concentrations of 0.2 mg/1 and 1 mg/1 5 hr dally S times a wk for 5 mo. The course of the sexual cycle was disturbed with characteristic prolonged flow. The capacity for conception was substantially decreased. The average number of offspring decreased as well as their weight. Gonadotropic effects of the compound are Indicated. Women's work In the presence ot this compound should be regulated.--N. L. G. 122297. SUKHAREVSKAYA, T. M., L. S. SAVEL'EVA, and A. I. VOROTNIKOVA. (Novoslb. Santt. InSt., Novoslb., USSR.) Opyt prlmeneniya < -amtnokapronovol ktsloty pri khronlchrskoi Intoksikatsli benzolom 1 ego gomologamt. (Experience using `-amlnocapronlc acid In chronic poisoning with benzene and its homo tones.) GIG TR PROF ZABOL 14(12): 39-41, 107O[rccd, 197l|.--* -Armnocapronlc acid, vitamins Bg and B12, glucose and Fe preparations were used to treat 12 patients with chronic poisoning by benzene and its homologues with symptoms of hemorrhagic diathesis. A hemostatic effect was obtained in 12- days in patients with mild symptoms of hemophiUa and in 2-3 day days in those with pronounced manifestations of diathesis, in addition to the hemostatic effect, capillary permeabiuty and the fibrinolytic activity of the blood decreased and blood coagulation time speeded up. The number of mature platelets Increased after treatment and the num ber of old thrombocyte forms Increased.--N. L. G. 122298. MAN'KO, N. N. (Inst. Hyp. Toxicol, pestle. Polym, plas^^ Subs!., Kiev, USSR.) Obosnovanie predel'no dopustlmol kontsentrat^^A Fozalona v vozdukhe rabochei zony. (Substantiation of the maxlmun^^y permissible concentration of Fozalon In the air of a production area. &1g TR PROF ZABOL 13113): 4(=MT"Ulua. 1470|recd,' 19711.--We"  '75521-75530 . TOXICOLOGY (Vol. 52(13)] 7554 '"7^52)* KUDRYAVTSEVA. O. F, (Dzerzhlnsk Inst. Ind. Hvg. Occup. "^gTrilirrihiB-ik. USSR.) K khnrakleristikc rlrklrnkarrilngrafichcsklkh tzrocfiroll u holriykh khmnirhrskoi in^oksikatsici khlrtrintym vlnitom. ICharnrlrrint^r!! circirpcardiotfraphtf changes in patients with vinyl chloric1<t_pf1isnntnC. 1 OiCTTR PROF ZAHOt. M(R): 54-!>6.' 19^5"--eG ndies of 50 male and 43 female workers suffering chronic vinyl chloride Ilisonfng revealed cardiovascular disturbances manifested as changes rhythm, conductance and repolari^ation processes and an increase in svstohe index. ECG data should be used to determine the condition of the heart when evaluating the degree of vinyl chloride poisoning in a patient,--C. P, 75522. PENKKOV1CH. A. A.. 1. S, FAERMAH. and E. V. GLADKOVA. (Inst. Ind. Ilyg. Occup. Ds.. Gorki, USSR.) K voprosu ob otsenke I soflloyanfi funktsh vneshnego dvkhaniya pri pylevykh rabolcvanivakh bronkho* legoehnogo apparata. [The evaluation and state of the external respira tion function in doslindurod disorders of the broncho-pulmonary system.1 GIG TR PROF ZADOL 14lll]: 7-10. 1970. (Engl. sum.|--The nature and extent of changes In a number of ventilation figures were dependent on the decree of respiratory incompetence and the form and stage of the coniotic process in the lungs. The results of 1459 examinations were subjected to electronic data processing. The most specific indices char acterizing the disturbed external respiration function were the maximum pulmonary ventilation, maximum expiration rate and the arterial blood O2 saturation. No conclusive differences of ventilation figures in pa tients with dissimilar forms and stages of pneumoconiosis could be dis closed. The most serious disorders of the ventilation function were noted in patients with pneumoconiosis accompanied by clinical manifestations of chronic bronchitis.--C. M. M. 75523. IL'INA. V. A., and T. A. KOCHETKOVA. (Inst. Ind. Hyg. Oc cup. Dts., Acad. Med. Sci. USSR. Moscow, USSR.) Eksperimental'nyi pnevmoskleroz pri vdykhanii aerozolei magnievolitlevykh splavov. (Ex perimental pneumosclerosis from inhalation of magnesium-lithium alloy aernsols.l GIG TR PROF ZABOL 14(2): 17-21. 1970. (Engl, sum. I-- When inhaled. Mg-Li alloys hare an irritating action on the mucosa of the upper respiratory tract and pulmonary tissue and cause a number of changes in the respiratory organs. These include moderate catarrhal tracheitis, bronchitis, interstitial pneumonia, diffuse sclerosis and em physema of the lungs. The extent ot ihc pathological process becomes greater as the LI proportion in the alloy increases.--C. M. M. 75524. ZHDANEEVA. G. S. O rentgenologicheskikh izmeneniyakh v legkikh pri intoksikatsti karbonil-nikelem v ostrom 1 otdalennom period- (X-rav changes in the lungs with nickel carbonyl poisoning in the He phase and later.I KAZAN MED ZH 1. 47-50. 1970. Translated m REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSKOL, 1970, No. 7.54.769.--In 5 men and 2 women (of whom 6 were 21-31 yr old and 1, 52) who had undergone acute poisoning from Inhaling nickel carbonyl, observations were made Of the organs of the thorax for 7-12 yr. On the 2nd or 3rd day after the poisoning, a high position of the diaphragm was noted. The respiratory movements of the diaphragm were not determined or were limited. There was reduced air content of the pulmonary field. Two patients showed intensification and vaguesness of the lung picture and of the roots of the lungs and the remainder also showed bilateral foci. Retrograde development of the X-ray changes began on the 7th-12th days. The outcome of the poisoning was favorable in all the young people. Dynamic observations for 10-12 yr showed that they were completely recovered. Regression of the X-ray changes in the older patient was noted until the 29th day. The position and respira tory movements of the diaphragm were restored in 3 mo. The picture of the lungs and roots became as they originally were in 2 yr after the poisoning. After 7 yr the patient developed pneumosclerosis, cardio sclerosis and stage 1 respiratory insufficiency. Nickel carbonyl poison ing is probably not the determining (actor in the growth of the sclerotic process. Its principal toxic effect is a disturbance of the lung capil laries and arterioles. Acute poisoning in healthy persons does not leave after effects.--S. T. 75525. OSETROVA. V. I. Sostoyanie zdorov'ya rabochikh tsekha flotofabnki Berezmkovskogo kaliinogo kombinata po dannym periodichesklkh meditsinsktkh osmotrov. (The health of workers at the flotation compound plant of the Bcrezovskii Potassium Combine, according to data from periodic physical examinations,I TR"pERM'MED"lNST 62: B8-90. 1970. Translated from REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSKOL, 1970, No. 10.54.757.--Of 137 workers examined 70% were women, 50 had worked less than 10 yr and 77 more in the flota tion compound plant of the potassium combine. The potentially occupa tionally harmful products there consisted of higher aliphatic amines of fatty acids at concentrations tens of times the maximum allowable with a relative humidity of up to 96'J. and temperature In the plant of up to 30'C. The patients complained mostly of headache. Of those examined, 50" showed moderate tachycardia, dulling of heart tones, labile blood pi unsure and functional CNS disorders. Tenderness In the right sub- at area was noted in 18 patients and urnblltn was found In the urine |ost of those examined. Equipment operators exposed most to amines red an Increase tn the number of reticulocytes and thrombocytopenia. --S. T. 75526. MOZAN. C., A, IJICQUANITJ, and L. PETTINATI. (1st. Med. Lav., Turin, Italy.) Evaluation du risque induil par les loxtques indus tries. (Evaluation of Ihe hnrz-irds rrealed by Industrial inxins.) ARCH MAL PROF MED THAV SEC SOC 3llll: 141-146. 1970.--The means of evaluating the atmospheric hazard ereaied hy Industrial toxins that are currently practiced appear to be unsatisfactory and open to criticism. Results obtained with them arc inadmissible. The problem of normaliz ing systems ot sampling and quantitative determination of toxins is pres sing and essential. Well-defined norms should be given regarding the speed of air sampling and Ihe point or points where sampling is to be done. In evaluating the risk Involved. Ihe phenomenon of toxin condensatton upon different surfaces of work areas which become secondary sources of pollution must nof be forgutlcn. The only system appearing to show this part of the hazard is that of quantitative determinations in series, even at times when the specific risk is theoretically null, so that characteristic profiles for each work cycle can be obtained. Even tn this ease, a standard method should be used to obtain comparable and reproducible evaluations. This Is the only way to obtain valid param eters of the hazard created by atmospheric toxins. These parameters are essential for a program of organized and systematic prevention. -S. L. R. 75527. FUJU. TAMOTSU. (Osaka Univ. Med. Sch.. Osaka. Jap.) (Pneu moconiosis caused by ~Scndo~ dust among rush-mat workers.) NIPPON ACTA RADIOL 30(3): 266-286. Illus. 1970. (In Jap. with Engl. sum.]-- Fancy mat workers are exposed to dense dust of ~sendo~ (a sort of day used to dye rush) in the process of rush-mat manufacturing. In order to confirm the possibility of the development of pneumoconiosis due to "sendo", mass survey of workers in domestic rush-mat workshops was performed by direct chest roentgenography. Pneumoconiotic nodules found in the roentgenograms were not uniform in size. These shadows were mainly composed of punctiform opacities from 0.5-1.0 mm in di ameter and were distributed evenly throughout the lung fields. Because of the smallness of individual dust focus, sparse opacities in the early stage of pneumoconiosis were difficult to demonstrate in routine X-ray film. More pneumoconiotic nodules were usually evidenced in the direct 2-fold magnification radiograms than in conventional films. These find ings were similar to those of some sorts of atypical silicosis and other nonsilicotlc pneumoconioses, especially pneumoconiosis caused by clay dust inhalation. Fibrous thickening of the pleura due to pneumoconiosis was not remarkable. Hilar shadows showed no enlargement. Pulmonary emphysema was not so conspicuous. As to the complications in the lung, cases with active pulmonary tuberculosis were not seen. Of 47 workers with distinct pneumoconiosis, 17 had slightly impaired lung function and 6 had moderate impairment. Pneumonconiotic workers should be removed from areas of high dust exposure to protect them from the de velopment of the disease. "Akashl Sendos" which are used in Okayama Prefecture, are composed of about 20% quartz and many kinds ot clay minerals. The pneumoconiosis due to 'sendo" is a sort of atypical silico sis caused by the dust which contains free silica in low percentage and. at the same time, may be Included in clay pneumoconiosis.--C. M. M. 75528. IL'INA, V. A. (Inst. Ind. Hyg. Occup. Dis., Acad. Med. Sci. USSR, Moscow, USSR.) Voprosy gigieny truda pri poluchenii i obrabotke magnievolitlevykh splavov. (Occupational hygiene in obtaining and treat ing of magnesium-lithium alloys,I GIG SANIT $5(16): 24-in. 1970. (Engl, sum.]--Working conditions at the open-pit mining of Mg-Li alloys are characterized by the almost continuous formation of aerosol and its discharge into the air of the working zone. The aerosol dispersed phase consists mainly of lithium oxide, lithium carbonate, lithium chlo ride, lithium fluoride and magnesium oxide. The main sign of the inhaled effect of Mg-Li alloy aerosols is the development of an inflammatory pro cess In the respiratory tract and the lung tissues: tracheitis, bronchitis and interstitial pneumonia resulting in diffused pneumosclerosis and lung emphysema.--C. M. M. 75529. BATOL5KA, A., and H. MARINOVA. (Inst. Mai. Prof. et. Prot. Trav., Sofia, Bulg.) Modifications du glutathlon chez les travailieurs d'une entreprise mctallurglque mlniere. (Glutathione modifications in workers of a mining metallurgical flrm.l ARCH MAL PROF MED TRAV SEC SOC 31(3): 117-122. Illus. 1970.--A moderate clinical picture in dicating preliminary occupational poisoning was noted in workers having contact with Pb, As, Cd and Sb. Almost 1/3 of the workers had lowered Hb. Glutathione [GSH] amounts decreased. GSH inhibition was parallel to the length of time when contact with the substances occurred. The ef fect of glutatiol was favorable with regard to both the clinical picture and laboratory tests. Following administration of glutatiol, GSH concen tration, the reduced GSH/total GSH ratio and the amount of serum lactic dehydrogenase increased.--S. L. R. 75530. ASHBEL', S. I.. R. G. KHIL', I. L. YAKUB, and I. D. VOLKOVA. Ob effcktlvnostt lecheniya bol'nykh silikozom aerozolyami 1 elektroacrozolyami shchelochei. (The effectiveness of treating silicosis patients with aerosols and cleetroaerosols ot alkalies.) SB TR NAutH-lSSLED INST GIG TR PROFZABOL GRUZ SSR 12: 149-154. 1970. Translated from REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSKOL, 1970, No. 8.54.684.--Of 53 silicosis patients studied, 19, of whom 12 had chronic bronchitis, were treated with a 10% solution of sodium bicarbon ate (5 mi by inhalation at pH 8 for a course of 2 inhalations a day (or 10 R&S 131240 1 ( l W \ ( I ft l I I 108701-108713 NEOPLASMS AND NEOPLASTIC AGENTS [Vol. 52( 10)) 10844 '< Effprm -i DNA mnlcrular weight. INT J RADIAT IllOL 13(3): 337-24*1. niusn!T7l. |Fp. and ficr. *umm.|--The effects of in corporated 3it from trltiatcri dcoxvthymldlne ('H-T(lfl) on the molecular weight distribution of newly synthesized P38BF lymphoma erll DNA was Investigated, using the alkaline-sucrose sedimentation procedure. The average molecular weight of DNA tsotopleally labelled In the presence of excess 3H-TdR, was Inversely related to the level of Incorporated ^H, and Inversely related In a linear fashion to cell survival. Two DN\ components, of medium and high molecular weight are recognized and their possible Interrelation ship Is discussed. At low levels of 3h Incorporation, the mediumsized component IMnrs2.5x 10 daltons) Is converted entirely to the fraction of high molecular weight (M^v > 108 daltons) within 2 hr at 37C, but supralethal levels of Incorporated 3H, or Incubation at 47c, reduces the molecular weight of the larger component. The results suggest that the average molecular size of the newly synthe sized DNA of high molecular weight Is determined bv an equilibrium between strand breakage produced by Incorporated "*H and enzymatic elongation. t 108701. HILDERBRAND, J. (McLean Hosp., Belmont, Mass., 02178, USA.I, P. STRYCKMANS, and P. STOFFYN. Neutral glycolipids In leukemic and nonleukemic leukocytes. J LIPID RES 12/3): 361306. Dim. 1971.--Neutral lipids, free and total cholesterol, glycollpld and phospholipids were determined in 20 preparations of leukocytes distributed in 4 groups. Group 1 consisted of leukocytes fron non leukemic patients; group n, from patients with chronic myelogenous leukemia; group m, from patients with chronic lymphocytic leukemia; and group IV, from patients with acute leukemia. Two neutral glycolipids were found In nonleukemic mixed leukocyte populations. They were Identified as glucosylceramide and lactosylceramide. The same glycolipids were also present in leukemic cells, but striking differences in glycollpld composition were found in various types of leukocytes. Glycolipids accounted for 8.912.69 of the total lipids in leukocytes from group I, 11.4-20,4% in group 11,1.2-1.69 in group III and 0.5-4.99 in group IV. Glucosyl ceramide was the only glycolipid found in 7 out of 8 analyzed samples of lymphocytes, both normal and leukemic, Lactosylceramide was the major glycolipid in preparations consisting mainly of polymorpho nuclear, myeloid and blastic cells. Only lactosylceramide was found in platelets, where its concentration was about 100 times lower than in mixed leukocyte populations. 108702. KAHANOWICZ-FEIERBERG, J., and L ZIPRKOWSKY. (Tel Hashomer Govt. Hosp., Tel Aviv, Isr.) fDermatological manifestations Of leukemia.1 HAREFUAH J ISR MED ASS 77(9)t 408-410. 1969|recd. 197UJ. (In Heb. with Engl, and Fr, Sum!]--Two hundred and twelve cases of leukemia of various types were reviewed. In 105 patients skin manifestations were present, 38 of which were specific for the disease and 67 non-specific. Fortynine patients presented with skin lesions as the 1st sign of the disease.--E, S. 108703. GOULD, J. F., and J. H. P. MAIN. (Dep. Dent. Surg., Univ., Edinburgh, Scot., UK.) Primary lymphosarcoma of the maxil lary alveolar process. ORAL SURG ORAL MED ORAL PATHOL 28(1): 106-108. Ulus. I969[recd. 1970).--Lymphosarcoma is a rare condition of high malignancy. It may begin in the lymphatic tissue of 1 anatomic site, or it may be more diffuse. In either case, it may spread to adjacent lymph nodes. It can also spread via the bloodstream and form distant metastases. Lymphosarcomas in the nasopharynx are not uncommon, but those presenting as solitary lesions in the jaws are rare. For this reason, the present case is considered to be of some interest.--E. S. 106704. FRANK, WERNER, and ARWID SCHEPKY. (Zool. Inst., Univ. Stuttgart-Hobenheim, West Ger.) Metastasierendes lymphosarkom bei elner Riesenschlange, eunectes munnus (Linnaeus, 1758). (Metastasizing lymphosarcoma in an anaconda. Eunectes munnus (Tinnaims, 1755).! PAlitOL VEt' 6(5): 437-443. Illua. 1969|recd. 1970). [Engl. sum.]--This report of a tumor of the hemato poietic system in an anaconda snake, Eunectes murinus, is the 1st of such a growth in a reptile. The primary site was apparently in undifferentiated mesenchymal cells in the liver and secondary deposits occurred In the thyroid, spleen, pancreas and kidneys. The lymphoblast was the predominant ceil type in all of these organs. The tumor is designated as a lymphosarcoma.--E. S. 108705. GLINSKA, HALINA, and BOGUMIL ADAMCZYK. (Inst. Onkol., Cracow, Pol.) Badania elektrotoretyczne blalek surowlcy krwi u ehoryeh z miesakami limfatycznymi. [Electrophoretic lnvestlgations of serum proteins of patients with lymphosareotnaTl N5WOTW6RY 19(4): 257-2G2. 1969[rec'd. T47o|. [Engl, and Russ, sum.|--Electrophoretic determination of blood serum proteins was carried out In a group of 32 patients with microscopically confirmed lymphosarcoma. Hvpoalbumtnemla and hyper nj-globulinemla were observed In all patients. A correlation was found between the degree of dysproteinemla and the clinical course as well as the presence of liver metastases.--E. S. 108700. CHOTFCKI, nOHDAN, HALINA JOIIANOW1CZ, GRZEGORZ KOCIOKEK, and ALEXANDER LAUOANSKI. ful. Okopowa 20 m. 1., Lodz, Pol.) Lymphoblastoma macrofolllcularc (Morbus Brill-Symmersl). I Macrofoli leular lymphohla stoma (Brill-Symmers disease).! OTOI-AliYNGOL POL 24(51: 535539. Ulus. 1970[ reed. 1971]! |Engl. and Russ, Bumm.|--The course, diagnosis and prognosis In Brill-Symmers disease are described and the possibility of transformation of this disease Into a malignant lymphoblastoma Is suggested. Observations of the treated patients are Included,--E. S. 108707, FAKHRI, O., and J. R. HOBBS. (Roy. Postgrad. Med. Seh., London, Engl., UK.) The serum paraprotein levet relaled to the number of plasmaevtoma-5563 cells In C3I1 mice. bitlT J CANCER 24(2): 3'JS-j()7. lllus. 1570.--An ascitic form of plasma cytoma (MP-5563) In C3H mice proved stable On transplantation. A simple linear relationship was demonstrated between the serum level ol the paraprotein produced and the total number of plasma cytoma cells within the ascitic fluid.--E. S. 108708. FAKTIRI, O. .(Roy. Postgrad. Med. Scti., London, Engl., UK.) The growth characteristics of an ascitic plasmacytoma (MP 5S&3) terminating bv fistulous communication with the blood stream....BRIT J CANCER 24(2): 389-354711!us. lS70.-The.. growth of ascitic mouse plasmacytoma 5563 was monitored by "Crred blood cell (RBC) dilutions within the peritoneal cavity together with differential cell counts and protein production measurements. Following the l.p. transplantation of one million tumor cells, there la a latency period of 4 days, possibly explained as only a 5% survival of the Inoculum. This is followed by logarithmic growth from 4-8 days with a doubling time of 18 hr, always similar in different animals. Eventually after 8 days and alter about 100 million cells an asymptote is reached which is due to a fistula-like communication between blood stream and peritoneal cavity. This terminal phase (9-10 days) is rapidly followed bv death of the mouse. Reliable tumor cell counts can only be achieved between 4 and B days.--E. S. 108709. PILCHER, J., and M. ZUBAIR. (North. Gen. Hosp., Sheffield S5 7AU. Engl.. UK.) Hodgkins disease and pericardial effusion. THORAX 25(5): 631-633. Ulus. 1970jrecd. 1971).--A case of Hodgkin's disease presenting with pericardial effusion is described. The relevant literature is reviewed.--E. S. 108710. RUSTEIfCA, P. B,, and P. L TARVIDAS. Soderzhanit Al, Nl, Zn, Mn, Cu, Ti, v tsel'not krovi krupnogo rogatogo skota prt khronicheskom limfoleikoze. [Content of aluminum, nickel, zinc, * manganese, cornier and titanium In the blood of cows with chronic lymphoid leukemia. | TR AKAD NAUK LIT S5R SER V BIOL NAUK 1. 177-180. 1&70. [Engl. summ.J--ISP-28 spectrography was used to determine the serum content of some metallic elements in cows with Chronic lymphoid leukemia. The Al content was 2.& times and the Nl content was 1.5-2 times that of normal animals. A 19% decrease in the Zn content was noted In leukemic animals. The Mn, Cu and Tl content remained unchanged.--E. S. 108711. RUSTEIKA, P. B. Soderzhanie Al, Nl, Zn, Fe, Mn, Cu, Tl v syvorotke krovi krupnogo rogatogo skota prl khronicheskom limfoleikoze. [Content of aluminum, nickel, zinc, manganese, iron, cornier and titanium in the blood of cows with chrome lymphoid leukemia.I Trt AKAB NAUk Lit SSR SEft V BtOL NAlfK 1. 181- 185. 1970. [Engl, summ.]--ISP-28 spectrography was used to determine the content of some metallic elements in cows with chronic lymphoid leukemia. The Al content was 6 times and the Mn content was 1.5 times that of normal animals, A 20% decrease In the Zn content was noted In leukemic animals, while the Fe, Cu, Ti and Nl content remained unchanged.--E. S. I 1 i I I l I 108712, OGAWA, MAfOO, DORIS H. WURSTER, and O. ROSS McINTYRE. (Dartmouth Med. Sch., Hanover, N. H., USA.) Multiple myeloma in one of a pair of monozygotic twins. ACTA HAEMATOL (fiXSEL) 44(5): 295-304. Ulus. l970|recd. 1471].--A case of multiple myeloma in 1 of a pair of monozygotic twins is described. Cytogenetic studies of the blood and bone marrow cells revealed that both of the twins had aneuplold cells with numerous inconsis tent abnormalities and 1 consistent abnormality (an extra chromo some of a size corresponding to No. 19-22 elements) in a low per centage of cells. The significance of this case and the cytogenetic findings with respect to the role of genetic and environmental fac tors in the pathogenesis of myeloma is discussed.--E. S. 108713. SCHWEYER, H., J. R. RUETTNER, and G. PEDIO. (Inst, Pathol. Anat. Univ., Zurich, Switc.) Thrombozytopenie belm experimentellen HIPA plasmozytom dor BALB/c Maus. [Thrombocytopenia In experimental HIPA plasmacvtoma in BALB/c mouse.| ACTA HAEMATOL (BASEL) 44(b): 3ff5-319. Ulus" 1970[recd. 1971]. [Engl, sum.]--The transplantable HIPA plasmocytoma of BALB/c mice Is usually associated with hemorrhagic ascites. Serial thrombocyte counts were made from the day of transplantation I Uri to V a lb to a nM Incr dirr and dam 1* TR2 Fes grai Op^i thvr in.: are The wer nos Y' thyr 1C Afr* IS? Bur. res; insc hist Sout cone of ti Burl TK Der rat 51 b 12 r lunc the . wer. and of lu of th turn' nun*. nose rep tK NEV USA care of p: live: hepa had eithi was inCi: men Daw gem t It and Ma in n X: con dos* nr redu dipt thcr test the Of u eye; the* do* uret R&S 131241 / ./> - -/ I C.tr- / 4 IN TICIMEXTART aYa'TEM (V i. j).: , 474 sirrrlc tec?-nlaue Ior m^n*-jrtnir skin r^ndurl 1\ ifv. MED RTOL ENG "1? 41; ^.n^T;ill,^. 1(>72.--A simple portable apparatus Js described for mondortnc the conductivity of the skin. After the Bfcysioleglral rationale of the technique Is appreciated, a means of Hsesslng nonspecific responses to various stimuli will be provided. W J. J. B. 8432. CRAMER, H. J. (Hautklln. Med. Akad., Element-Gottwa Id - St. 34, DDR-501 Erfurt, East Grr.) Untrrsuchungen zum Naehweis gebundener bzw. masklerter Llplde In der Dermato-lllstolople. jgtudles on the drlertlon of bound or masked lipids In dermatn- .7 bKJTMAf'oi. MONATSSCnn ' fioT-itffl'/ liTiw. RTlfrrcil. 1972). fEnfcl, Pumm,|-Four methods were used to de* teet masked lipids Including: longer staining time, higher temper ature, Berenhaums's C-mrthod, and the Sudan-Burnt Berenbaum techniques. These methods were poor in 75 biopsies of various dermatosis. The importance and problems of paraffin sections, Sudan black as an indicator and control extractions were presented. --A. V. S. 8433. SCUTT, R. W. B. (R. Navy Hosp., Hasla r, Gosport, Hants., Engl., UK.) The chemical removal of tattoos. BRJPLASTSURG 25(2): 189-194. Ulus. 197^--A modification of a well-tried chemical technique for removing tattoos is presented as a safe, simple and effective out-patient procedure requiring virtually no after-care. A solution of tannic acid, glycerine and distilled HjO (2:1:1) Is swabbed over the area and tattooed Into the skin. A silver nitrate stick is rubbed over the area.--J. L. S. PATHOLOGY See also: Allergy Immunology (Immunochcmistry), especially Immunopathology (Tissue Immunology) Medical and Clinical Microbiology (includes Veterinary) Neoplasms and Neoplastic Agents Parasitology (includes Ecto- and Endoparasltes) Pathology, General and Miscellaneous - Inflammation and Inflammatory Diseases Public Health - Epidemiology Toxicology mi434. TRONNIER, R. (Univ. Hautklln., D 74 Tuebingen, West. .) Experlmentalle Entzuendung der Haut bel Tier und Mensch. _ perimental inflammation of the skin In animals and man.l 1NT i KLIN PHARMAKOL THER TOXIKOL 5(2): 152-165. Ulus. 1971 [reed. 1972). [Engl, summ.)--Several models of inflammation are described without detailed data on experimental performance. ~J. J. a t 8435. SZALAY, GLENN C. (South. Calif. Perm. Med. Group, 1050 West Pacific Coast Highw., Harbor City, Calif. 90710, USA.) and E. DAVID WEINSTEIN. Questionable Bloom syndrome in a Negro girl. AM J DIS CHILD 124(2): 245-248. Illus. 1972.--The Bloom syndrome, a genodermatosia, is described here for the first time in a Negro; the patient did not manifest telangiectatic erythema, one of the cardinal features of the syndrome. A new subgroup of the Intrauterine growth retardation syndrome was not postulated.' Her condition satisfied the other 2 major criteria of the Bloom syn drome and multiple minor criteria, including parental consanguinity and chromosomal changes. f t^43sT' MEYEISON, LAWRENCE B. (Irving Med. Prof. Village, '' 2101 MacArthur Blvd., Irving, Tex. 75061, USA.) and GERHARD C. MEIER. Cutaneous lesions in acroosteoiysis. ARCH DERMATOL 106(2); 224-22'?. Illus. 1972,--A patient with idiopathic acroosteoiy sis had unique papular skin lesions. Evidently, similar lesions were previously mentioned only in connection with acroosteoiysis seen in vinyl ehlorlde processing, and a detailed description of these was not noted In the literature. t 8437. GIROUX, JEAN-MARIO 'Hotel-Dieu Montreal, 3840 Saint Urbam, Montreal 131, Que., Can.) and ANDRE BARI3EAU. Erythrokeralodermla with ataxia. ARCH DERMATOL 106(2): 163-inh, Illus. 1972.--An apparently new neurocutaneous syndrome was observed In 25 members from over 5 generations in a family of French Canadian ethnic background. The syndrome is characterized by the appearance soon after birth, of papulosquamous erythematous plaques which have mild variations in intensity and which tend to sub side during the summer months. In most cases, the cutaneous mani festations almost disappear near the age of 25, sometimes to reapi- ar after the age of 40, At that time, a slowly progressive neuro- ;al syndrome, with decreased tendon reflexes, nystagmus, rthrla, and severe gait ataxia, becomes the predominant feature, syndrome Is inherited in an autosomal dominant fashion, t 843R, UITTO, JOUNI, SEPPO LiNDY, IIEIKKI TURTO and LB DANfELAEN. fDep, Dermatol., Univ, Copenh,, BlegdamaveJ 9, 2100 Cofwnhagen, Den.) Lactate dehvdrocenase in Pseudoxanthoma elasilcum: Total arilvily and isoenzyme distribution in th* skm._ .TINVEST ISfcltMATO!V" 55(2T." m-l^ Illus. 1972.'.-:fetal ailivity and Isoenzyme distribution of lactate dehydrogenase fLDII) were as sayed id Ihc skjn of patients with pseudoxanthoma elasticum (PXE). The values oixalned from lesions of 9 patients with typical PXE were compared to those obtained from 8 age-matched controls. In the skin, all LDH Isoenzymes, with the exception of LDIIj, could be detected, LDII5 being the predominant one. The Isoenzyme pattern in PXE was characterized by decreased LDI1 activity in inoenzyme fraction LDH5 and increased in fraction LDIIj, as compared lo the controls, in agreement with these changes, the relative proportion of polypeptide M, the sub-unit predominant In cathodic Isoenzymes, was decreased In PXE. Total LDH activity wan not chanced In thin disorder. t 8439. MARCOLB, MARVIN H. fDep. Dermatol., Univ. Wis. Med. Cent., 1300 University Ave., Madison, Wis., 53706, USA.), GARRETT A. COOPER and STUPE A. M. JOHNSON. Keratosis lichenoides Chronica. ARCH DERMATOL 195(5): 739-143. illus. 1972.--A patient had a unique IS yr history of a progressive, recalcitrant, papulosquamous eruption and persistent hoarseness. Histologically, the eruption showed parakeratosis, orthohyperkeratosis, atrophy of the malplghlan layer and a lichenoid histiocytic and lymphocytic dermal infiltrate. This cutaneous eruption, previously unreported, should be designated 'keratosis lichenoides chronica." t 8440. FBHER, LOUIS E. (Div. Dermatol., Scripps Clin., Res. Found., 476 Prospect St., La Jolla, Calif. 92037, USA.) and HOWARD I. MAIBACH. The effect of occlusive and semlpermeable dressings on the mitotic activity of normal and wounded human epidermis. DR J DERMATOL 86(6): 593-699. 1972.--Occlusion increased the rate of closure of superficial wounds and inhibited cell division both of psoriatic lesions and stripped skin. Four dressings: an occlusive, adhesive tape; the adhesive backing from this tape; a less occlusive adhesive tape; and an occlusive, non-adhesive film, were used to cover regions of normal and stripped skin for periods from 2-6 days. A slight increase In mitotic rate and epidermal thickness of normal skin resulted. A decreased mitotic rate and increased thickness of stripped skin, under all dressings was found. The less occlusive films msy be useful In accelerating the healing of wounds wtthoid adding the risk of infection seen under complete occlusion. t 8441. STEKSTROM, STEN (Dep. Plastic Surg., Univ. Hosp., Umea, Swed.), FRANK BERGMAN and SVEN BERGMAN. Wound healing with ordinary adhesive tape: A clinical and experimental slffir~5<:/Nb J frost ftfeCONSTR SUftG 6(11: 4n-46. Ulus. 1972.--The good clinical experience of treating human wounds with ordinary adhesive tape is presented. These experiences are com pared with the results of experiments on animals concerned with the healing time of wounds and histological and bacteriological conditions. t 8442. LEWIN, KLAUS (Dep. Pathol. Stanford Univ. Sch. Med., Stanford, Calir. 94305, USA.), SHARON DE WIT and RICHARD A. FERRINGTON. Pathology of the finger nail in psoriasis; A clinicopathologlcal study. BR J DERMATOL 86(6): 555-563. Illus. 1972. --Seven cases were studied. Psoriasis of the finger nail produces a metaplastic change of the nail matrix and nail bed to skin-like epi thelium, following which the histological changes are essentially similar to those seen in the skin. The resulting lesions of the finger nail are of 2 types: nail plate abnormalities, the nature of which de pends upon the site and the duration of disease in the matrix; and nail bed abnormalities, consisting of onycholysis, subungual keratosis and splinter hemorrhages. 8443. GWIEZDZINSKI, ZENON and BOHDAN SZ75ZYMAR. (Stud. Med. Sere, tmprov., Bydgoszcz, Pol.) Dwa przvpadkl masto cytosis cutis solitarla (naevlformls) u dziccl. (Two cases of masto cytosis cutis HOlltarln fnaevlformla) In children.] PEDIATR POL 48(6): 783-1857 Illus. 1971|rccd. 19121.--The 2 reported cases of this disease are characterized by a rarely recorded localization. Darter's symptom is Implicated in the clinical diagnosis of some skin rashes of the birthmark type. The rashes were found on the face and neck. A positive Darter's symptom Is more indicative than histological examination. Microscopic analyses may prove mis leading owing to the trauma during sectioning and possible inac curacies during the making of slides resulting in disintegration of the metachrome granulations in mast celts, --(Courtesy NSF PL 83-480). PHYSIOLOGY AND BIOCHEMBTRY t 8444. OIIKAWARA, AKIRA, KENNETH M. IIALPRIN (1201 Northwest 16th St., Miami, Fla., USA.) and VICTOR LEVINE. The enzymes of glycogen metabolism In the various cell fractions from the normal human epidermis. J INVEST DERMATOL 59(2): IBl191, Illus. 1972,--in the normal human epidermis, glycogen synthe tase Is sedimented with glycogen as Is the glycogen synthetase D phosphatase which converts the D to the I form. Glycogen synthetase ZVZISl s * u 1107 (Jnn. IS. 1913] TOXICOLOGY 11445-1H58 environmental and industrial toxicology Sre also: Public Health - Occupational Health, Radiation Health t 11445. JONES, ft. D. (Pham. Dlv,, I. C. I. Ltd,, Aldorley Park, Macclesfield, Cheshire, End., UK.), B. T. COMMINS and A. A. CFRNK. nlnort lead and carhoxvhaemoeloliln levels in I/inrinn taxi drivers. LANCET (NORTH AM ED) --2(7772): 302-303. 1972.--Among 50 London taxi drivers the mean blood-lead was 28,7 pg/100 ml. There was no dlltcrcnre ol statistical significance in the blood-levels of smokers and non-smokers, nor between the blood-leads of night-shift and day-shift drivers, Carboxyhemoglobin levels of smokers were significantly higher than those of non-smokers, and the levels were significantly higher In day drivers than In night drivers. t 11446. MC INTDIE, MATILDA S. and CAROL R. ANGLE. (Dep. Pcdiatr., Univ, Ncbr. Coll. Med,, Omaha, Nebr, 68I0S, USA.) Air lead: Relation to lead In blood of black school children deficient in clueose-fi-n hosphatc dehydrogenase, SCIENCE (WASH) 177(4048): 520-422. Ulus. 19T2.--Black children (44) at 2 elementary schools within 0.7 mi of a battery plant had significantly higher (P<0.01) concentrations of Pb In their bloods (34.1 * 9.7, pg/lOOmm, mean * SD) than 122 students (26 J * 7,1) at 7 schools 1-3 ml distant; 5 mo. later there was a comparable difference between red ceU Pb values (54.1 + 18.5 vs. 37,4 - 12.6). Among the blacks, those deficient in glucose-6-phosphate dehydrogenase had a higher (P<.005) concentra tion of Pb in the blood after correction for anemia (32.9 + 9,7) than the nondeficient (25.7 _* 8 J), and a higher concentration in the red cells (47J * 14.7 as compared to 35.6 * 15.8 P< .001); the enzyme effect was independent of geographic location. t 11447. MARKOWITZ, SAUL S,, CHARLES J. MC DONALD (Roger Williams Gen. Hosp., 825 Chalkstone Ave,, Providence, R. 1.02908, USA.). WILLIAM FETHERE and MARVIN S.KERZNER. Occupational acroosteolysls. ARCH DERMATOL 106(2): 219-223. nius. 1972.-- Occupational acroosteolysls is an unusual disease In which aflected persons have sclerodermold-like lesions of the skin, conditions similar to Raynaud's phenomenon, and asymptomatic, bony defects of the extremities. Evidently, the disease is confined solely to workers In the plastics industry, specifically those engaged in the production of polyvinyl chloride from vinyl chloride. The incidence of the disease is unknown but is thought to occur In 3% or less of workers. t 11448. WILDISH, D.J, (Pish. Re*. Board, Can. Biol. Stn,, St. Andrews, N. B., Can.) Acute toxicity of polyoxyethylene esters and polyoxyethylene ethers to S, salar and G. oceantcus, watch 6(7); 759-762. Ulus. 1972.--polyoxyethylene ethers are more toxic to aquatic fauna than polyoxyethylene esters. Polyoxyethylene (4) lauryl ether is 9 times more toxic than polyoxyethylene (14) monolaurate at the ILL [incipient lethal levels] to Salmo salar and 14,000 times more toxic at the 96-hr LC50 [lethal concentration median] to Gammarus oceantcus Sergestrale. t 11449. HOFMANN, A. (Inst. Toxlkol., E. Merck Darmstadt, D-6100 Darmstadt 2, West Ger.) and M. NEUFELDER. Tierexpertmentelle Untersuchungen zur gewerbetoxikologischen Beurteilung von 2-chloraethylisocyanat. fAn investigation of 2-chloroethvl Isocyanate in laboratory animals with regard to the implications as a potential occupational hazard,I ARCH TOX1KOL 29(1): 73-84. Ulus. 1972. [Engl, summ.j--The acute oral toxicity of 2-chloroethyl Isocyan ate (CAIC) is 396 mg/kg for male rats and 630 mg/kg for female mice. The extremely small quantity of 5 pi CAIC caused severe Irritation in the eyes of rabbits, particularly of the conjunctiva. The eltin was abo affected considerably, inhalation experiments. Involving a new version of a proven method for generating air-vapor mixtures, pro duced no evidence of systemic toxicity, but let CAIC be classified as an irritant vapor to the respiratory tract. The LC50 for rate is 6,3 ppm after exposure for 6 hr, while rats In 2 experiments involving 10-day exposures to vapor concentrations of 3.1 and 3JB ppm, respec tively, survived. After a fortnight's withdrawal following each experi ment, histological examinations showed tracheobronchitis and broncho pneumonia but no pathological change In any other organ examined. A threshold limit value (TLV) of 0.02 ppm was suggested. t 11450. JOSE, FRANCISCO R. (Dep. Physiol. Hyg. Nutr., Univ. Philipp,, Manila, Philipp.) A study of lead hazard in some lead process ing industries. ACTA MED PHJUPP 8(2): 48-54. 1972,--TWo batlery plants, 2 paint establishments and 1 company manufacturing bad oxide were studied to evaluate the extent and intensity of Pb hazard. Methods of evaluation used were levels of Pb in air, and urinary Pb, ' stippled red cell count and clinical manifestations suggestive of Pb intoxication among employees In the establishments. Levels of Pb in air, Pb concentration in the urine and stippled red cell count were higher In Use lead oxide and battery plants than In those engaged In paint manufacturing. Clinical manifestations suggestive of Pb poisoning were abo more frequent. Good correlation was observed between the laboratory findings and the clinical manifestations Indica tive of mild Pb poisoning. t 11451. GOODWIN, JOHN W, (Day, Zlmmermann, Inc., I/me Star Dlv,, Texarkana, Tea. 75501, USA.) Twenty years handling TNT in a hell Iwariing plant, AM IND MYG ASSOC J 33(1). 41-44. Ulus. thr handling of TNT within Iho mumlims industry, human exposure to thin substance cannot be completely avoided. Hie goal of a Preventive Medleat Program is to prevent such exposures from causing any permanent damage to workers. Fxhaust ventilation with wet scrubbers, use of protective clothing, mandatory practice of good personal hygiene, and careful medical supervision have combined to accomplish thin goal. The use ot the Hiymol Turbidity Test in such a program was a valuable Indicator of liver malfunction. t 11452^-KRAMER, C. G. (Dow Chcm. Co., Midland, Mich. 48640, ~US7Q and J. E. MUTCHLER. The rnrrelatinn of clinical and environ- mental measurements for workers rxt>osod to vinyl chloride, AM IND HYG ASSOC J 33(1): 19-36. Illus. 1972,--A method 7x1^scribed for the statistical consolidation and correlation of environmental measurements and clinical findings using as an example a group of healthy male workers exposed routinely io vinyl chloride for period* up to 25 yr. Retrospective In nature the study reveals several statis tically significant effects from chrenlc exposures to vinyl chloride and traces of vtnylidene chloride, t 11453. EL-DAKHAKHNY, ABDEL-ARIZ and YASSIN M. EL-5ADK. (Dep. Occup.Health, High Inst. Public Health, Alexandria Univ., Alexandria, UAR.) Lead In hair among exposed workers. AM IND HYG ASSOC J 33(l): 31-34. lllua. 19)2,--In a study performed on 67 Pb exposed workers, a correlation was found between levels of Pb In hair and the biochemical and clinical finding*. A Pb level in hair of more than 30 ug/g could be considered as a sign oi excessive Pb level. t 11454. LAUWEAYS, R,, R. DELBROECK and M.D. YENS. (Unite Toxicol. Pathol. Travail, Catholic Univ. Louvain, Ave. ChapeUe-aux Champs 4, 1200 Brussels, Belg.) Automated analysts of delta-amlnolaevullnic acid in urine. CLIN CHIM ACTA 40(2): 443-447. Illus. 1972.--The addition of an internal standard of 5 -aminolevulinic acid to the urine allows the colorimetric determination of this metabolite without (he need of a preliminary chromatographic separation. The speed and accuracy make the procedure suitable for the periodic control of workers exposed to Pb. ' 11455. MKSIC, J. and S. HUKOVIC. (Inst. Fannakol. TiksikoU Med. Fak,, Sarajevo, YUgoslJ Uzrocl nastajanja kronicnog opstrukttv-, nog bronhitisa n radnika erne metalurgtje, (Causes of chronic obstruct tire bronchitis In ferrous metallurgy worksrsTT ARH HIG RADA u TOKSKOL 22(1): 9-32. Ulus. 19?i[recd. 197i). [Engl. summ.}--An analysis was performed on 400 people working and living under differ ent conditions of exposure to air pollution. Respiratory symptoms were questioned and the ventilation function of the lungs, O, and COj content of arterial blood, presence of allergic phenomena, data on smoking habits and the consequences in pulmonary and cardiovascular systems ware studied. The 8 metal tons that constituted the dust were investigated. Experiments were abo performed on frogs (Rana ridibunda).--J. F. L. 11456. GONCHARUK, E. I., A. A. POLYANSKII, 1.1. SHVAKO and A, A, CHKIN. (Dep. Public Hyg,, Kiev Med, Inst., Kiev, USSR.) Fazovye izmeneniya funktsll shchitovidnoi zheiezy u krys pri khronicheskom vozdeistvii dibromantina. (Phase alterations of thyroid function in rats exposed to the chronic activity of dibromanthm.l GIG SANIT 36(10): 108-109. Illus. 197l[recd, 1972].--The functional condition of the thyroid was studied in rats with 1-131 after drinking HjO with dlbramanthin concentrations close to those found in swtmming pools disinfected with this chemical. In the 1st mo. there was some excitation of thyroid function. In a 4 mo. experiment, this latter effect was replaced at later periods by pronounced inhibition. Harmful effects on humans are not certain,--N. L. G. 11457, FROLOVA, A. D. (On the methods of studying btotransformatlon of poisons In organisms.) PRAC LEK 24(2/3): 61-66. 1972. [Czech, and Engl, summ.j--The mechanism of the toxic effect of Industrial poisons was discussed. The lack of methods for Identifica tion of chemical substances and products of their transformation in biologic material, made these studies rather difficult. Simple methodic approach affording Indirect assessment of the fate of foreign substances in the organism had not yet lost its importance. The effectiveness cf proposed simple procedures for studies of the (ate ot poisons was demonstrated with 3 representatives from the series of tluorated compounds.--J, A. L, 11458. F1SEROVA-BERGEROVA, VERA (Reprints: Vera FiserovaBergerova Thomas, 145 S.E. 25th Road, Miami, Fla. 33129, USA.) and J. LUDVK CETTL. Elektricky model pro vstrebavani metaboba-^ muB a vyhicovan! benzenu u cloreka. (Electric model for the absorntitM metabolism and excretion of benzene in man.) PRAC LEK 24(2/3): ^ 56-60, Illus. 1972. (Russ, and Engl, summ.j--Hie values for the resistance and capacitiea in the electrical analogue were derived by analogy to physiological factors for a 70 kilo man (blood flow in tissue. R&S 131243 f 11 7 Ih. 1973] * toxicology tm'j-iHM ENVIRONMENTAL AND INDUSTRIAL TOXICOLOGY Ser aln: Public Health - Occupational Health, Radiation Health f 11445. JONFS, R, D, (Pharm. Div,, t, C. I. Ud,, Alderley Park, MaeclestleW, Cheshire, Enel., UK.l.B. T. COMMINS and A. A. CFRNDC. Blood lead and rarlmxvhnomoglobln levels in London taxi drivers,. LANCET (NORTH AM ED) ~2(7772): 302-303. 1972.--Among SO London taxi drivers the mean blood-lead was 28.7 (ig/100 ml. There was no dilference of statistical significance In the blood-levels of smokers and non-smokers, nor between the blood-leads of night-shift and day-shift drivers. Carboxyhemoglobin levels of smokers were significantly higher than those of non-smokers, and the levels were significantly higher in day drivers than tn night drivers. t 11440. MC INTIHF, MATILDA S. and CAROL R. ANGLE. (Dep. peniatr., Univ, Nebr. CoH. Med., Omaha, Nebr, 68105, USA.) Air lead: Relation to lead in blood of black school children deficient In clurpse-fi-p hnsphatc dehydrogenase, SCIENCE (WASH) 177(4045): 320-322. Ulus. lSTi.--Black children (44) at 2 elementary schools within 0.7 mi of a battery plant had significantly higher (P<0.01) concentrations of Pb tn their bloods (34,1 - 9.7, pg/lOOmm, mean + SD) than 122 students (26J - 7.1) at 7 schools 1-3 mi distant; 5 mol later there was a comparable difference between red cell Pb values (54.1 - 18,5 vs, 37.4 12.6). Among the blacks, those detketent In glucose-6-phosphatedehydrogenase had a higher (P<.005) concentra tion of Pb in the blood after correction for anemia (32.9 + 9.7} than the nondeficient (25.7 - 8.8), and a higher concentration in the red cells (47J * 14.7 as compared to 35.6 + 15.8 P< .001); the enzyme eflect was independent of geographic location. t 11451, GOODWIN, JOHN W, (Day, Zlmmermann, Inc., Lone Star Dlv,, Texarkana, Tex. 75501, USA.) Twenty years handling TNT in a shell loading plant. AM IND HYG ASSOC J 33(1). 41-44. Illus. 1572.--In the handling of TNT within the munitions industry, human exposure to this substance cannot be completely avoided. The goal of a Preventive Medical Program is to prevent such exposures from causing any permanent damage to workers. Exhaust ventilation with wet scrubbers, use of protective clothing, mandatory practice o( good personal hygiene, and careful medical supervision have combined to accomplish this goal. The use ol the Thymol Turbidity Test in such a program was a valuable Indicator d( liver malfunction. t 11452. KRAMER, C. G. (Dow Chem. Co., Midland, Mich. 48640, USA.) and J, E. MUTCHLER. The correlation of clmtcnl and environ mental measurements for workers exposed to vinyl chloride, AM IND HYG ASSQCJ 33(1): 19-30. Illus. 1972,--A method is described lor the statistical consolidation and correlation of environmental measurements and clinical findings using as an example a group of healthy male workers exposed routinely to vuiyl chloride for periods up to 25 yr. Retrospective in nature the study reveals several statis tically significant effects from chronic exposures to vinyl chloride and traces of vlnylldene chloride, t 11453. EL-DAKHAKHNY, ABDEL-ARI2 and YASSIN M. EL-SADDE. (Dep. Occup. Health, High Inst, Public Health, Alexandria Univ., Alexandria, UARJ Lead In hair among exposed workers. AM IND HYG ASSOC J 33(1): 31-34, Illus. 1972.--In a study performed on 67 Pb exposed workers, a correlation was found between levels of Pb In hair and the biochemical and clinical findings. A Pb level in hair of more than 30 pg/g could be considered as a sign of excessive Pb level. 11447. MARKOWITZ, SAUL S,, CHARLES J. MC DONALD (Roger Williams Gen. Hosp., 825 Chalkstone Ave,, Providence. R. I. 02908, USA.), WILLIAM FETHERE and MARVIN S. KERZNER. Occupational acroosteolvsis. ARCH DERMATOL 106(2): 219-223. Illus. 1972.-- Occupational acroosteolysls is an unusual disease in which affected persons have sclerodermoid-like lesions of the skin, conditions similar to Raynaud's phenomenon, and asymptomatic, bony defects of the extremities. Evidently, the disease is confined solely to workers in the pListics industry, specifically those engaged in the production t 11454. LAUWERYS, R., R. DELBROECK and M. D. VENS. (Unite Toxicol. Pathol. Travail, Catholic Univ. Louvain, Ave. ChapeUe-aux Champs 4, 1200 Brussels, Belg.) Automated analvsls of delta-amino- laevullnic add in urine, CLIN CH1M ACTA 40(2): 443-447. Illus, 1972.--The addition of an internal standard of 5-aminolevulinic acid to the urine allows the colorimetric determination ol this metabolite without the need of a preliminary chromatographic separation. The speed and accuracy make the procedure suitable for the periodic control of workers exposed to Pb. 3 Qo (/) _i. ( IO of polyvinyl chloride from vinyl chloride. The incidence of the disease is unknown but is thought to occur in 3% or less of workers. ' 11455, MDCSIC, J. and 5. HUKOVIC. (Inst. Fannakol. Tiksikol., Med. Fak,, Sarajevo, Yugosl.) Uzrocl nastajanja kronicnog opstruktiv- J* t 11448. WILDISH, D.J. (Fish. Res. Board, Can. Biol. Stn,, St. Andrews, N. B., Can.) Acute toxicity of nolvoxvethv)ene esters and polvoxvethvlene ethers to S. salar and G. occanlcus. WATER RES 6(7]: 759-762. Ulus. 19727--Polyoxyethylene ethers are more toxic to aquatic fauna than polyoxyethylene esters. Polyoxyethylene (4) lauryl ether Is 9 times more toxic than polyoxyethylene (14) monolaurate at the ILL [Incipient lethal levels] to Salmo salar and 14,000 times more toxic at the 96-hr LC50 [lethal concentration median] to Gammarus oceanlcus Sergestrale. nog bronhttisa u radnika erne metalurgije. (Causes ol chronic obstructive bronchitis in ferrous metallurgy workers.l ARH H1G RADA TOKSKOL 22(1): 9-32. Illus. I971[reed. 1972], [Engl, summ.]--An analysis was performed on 400 people working and living under differ ent conditions of exposure to air pollution. Respiratory symptoms were questioned and the ventilation function of the lungs, 6? and CC2 content of arterial blood, presence of allergic phenomena, data on smoking habits and the consequences In pulmonary and cardiovascular systems were studied. Hie 6 metal Ions that constituted the dust were investigated. Experiments were also performed on frogs (Rana ridi- t 11449. HOFMANN, A. (hist. Toxikol., E. Merck Darmstadt, D-6100 bunda).--J. F. L. Darmstadt 2, West Ger.) and M. NEUFELDER. TierexpertmenteUe Untersuchungen zur gewerbetoxikologischen Beurteilung von 2-chloraethylisocyanat. (An investigation of 2-chloroethvl isocyanate In laboratory animals with regard to the implications as a potential occupational hazardTT ARCH TOX1KOL 29(1): 73-84. Illus. 1972. [Engl. summ.J--The acute oral toxicity of 2-chloroethyl Isocyan ate (CAtC) is 396 mg/kg for male rats and 630 mg/kg for female mice. The extremely small quantity of 5 pi CAIC caused severe irritation in the eyes of rabbits, particularly of the conjunctiva. The skin was also affected considerably. Inhalation experiments, involving a new version of a proven method for generating air-vapor mixtures, pro duced no evidence of systemic toxicity, but let CAIC be classified as an Irritant vapor to the respiratory tract. The LCjo lor rats Is 11456. GONCHARUK, E, I., A. A. POLYANSKII, I. 1. SHVAKO and A. A, CHIKIN. (Dep, Public Hyg,, Kiev Med. Inst., Kiev, USSR.) Fazuvye lzmenenlya funktsii shchitovidnoi zhelezy u krys pri khronicheskom vozdeistvti dibromantina. fPhase alterations of thyroid function In rats exposed to the chronic activity of dibromanthui.l GIG feANIT 36(10): 108-109, Ulus. 1971[recd. 1972].--The functional condition of the thyroid was studied in rats with 1-131 after drinking H2O with dlbromanthin concentrations close to those found in swimming pools disinfected with this chemical, m the 1st mo, there was some excitation of thyroid function, tn a 4 mo, experiment, this latter effect was replaced at later periods by pronounced inhibition. Harmful effects on humans are not certain.--N. L. G. 6J ppm after exposure lor 6 hr, while rats In 2 experiments Involving 10-day exposures to vapor concentrations of 3.1 and 3.8 ppm, respec tively, survived. After a fortnight's withdrawal following each experi ment, histological examinations showed tracheobronchitis and broncho I pneumonia hut no pathological change in any other organ examined. A threshold limit value (TLV) of 0.02 ppm was suggested. 11457. FROLOVA, A. D. (On the methods of studying btotransformatlon of poisons tn organisms.! PRAC LEK 24(2/3): 61 -66, 1971. [Czech, and Engl, summ.]--The mechanism of the toxic effect of Industrial poisons was discussed. The lack ot methods lor identifica tion of chemical substances and products of their transformation in biologic material, made these studies rather difficult. Simple methodic f 11450. JOSE, FRANCISCO R. (Dep. Physiol. Hyg. Nutr., Univ, Philipp., Manila, Philipp.) A study o( lead hazard in some lead Tirocess- lng Industries. ACTA MED PHILIPP 8(2): 48-54. 1972.--Two bat- " iery plants, 2 paint establishments and 1 company manufacturing lead oxide were studied to evaluate the extent and Intensity of Pb hazard. approach affording indirect assessment ol the late of foreign substances In the organism had not yet lost Its Importance. The effectiveness of proposed simple procedures for studies of the fate of poisons was demonstrated with 3 representatives from the series of fluorated compounds.--J. A. L. Methods of evaluation uaed were levels of Pb tn air, and urinary Pb, stippled red cell count and clinical manifestations suggestive ot Pb intoxicabnn among employees In the establishments. Levels of Pb in air, Pb concentration in the urine and stippled red cell count were higher in the lead oxide and battery plants than In those engaged in 11458. FISEROVA-BERGEROVA, VERA (Reprints: Vera FiserovaBergerova Thomas, 145 S.E. 25th Road, Miami, Fla. 33129, USA.) and J. LUDVK CETTL. Elektricky model pro vstrebavanl metabolismue a vylucovanl benzenu u eloveka. (Electric model for the absorption paint manufacturing. Clinical manifestations suggestive of Pb metabolism and excretion of benzene In man.l PRAC LEK 24(2/3); poisoning were also more frequent. Good correlation was observed (>8-6Q, IUue. 1972. [Russ, and Engl. summ.|--The values for the between the lalmratory findings and the clinical manifestations Indica resistance and capacities tn the electrical analogue were derived by tive of mild I'b poisoning. analogy to phyaioioglcal factors for a 70 kilo man (blood flow tn tissue. .Y (Vol, 55(8)] 3558 ivcn in vivo ntetllwlv Inhibit! (or 10-80 min a nucleoplasmtc type of INA polymerase in rat liver but the synthesis in vivo o( all species of luclear RNA remains blocked for several hours,--J, F. L. 38771. BROOKS. ROBERT 17. Jr. and JAMES A. VICK. (Dep. Pharmcot.. Walter Reed Army Inst. Res., Walter Reed Army Med. Cent., I'ashinplon. D. C. 20012, USA.) Toxicological studies ol bee venom In nice, dogs and monkeys. AM BEE J 112(7): 150-251. 1972.--Venom I Ajiis mellifera was injected, either l,v, or s.c.. Into experimental niniais. I.V. injections caused a precipitous decrease In blood pres:urc within 35 sec in both dogs and monkeys. It also decreased heart ate and depressed respiration. Dosages of 5 mg/kg in dope, or 2.S ne/kg in monkeys, l.v,, caused death from cardiovascular failure, imtlar responses were noted after s.c. injections, but median lethal lot-ages were higher: 200 mg/kg in dogs and 50 mg/kg In monkeys, rhe former is equivalent to about 2000 bee stiogs. Smaller dosages rcrc fatal to mice. Other physiological reactions are noted. --J. D. Hitchcock. 34772. ULANOVA, I. P., A. 1. KHALEPOand A. I. E1T1NG0N. (Inst, nd. Ilyg. Occup. Dis., Acad. Med. Set. USSR, Moscow, USSR.) Issledoanie kumulyativnykh svolstv khimlchcskikh soedinenii na porogovom irovne kak osnova prognozirovaniya khronicheskikh Intoksikatsli, Study into cumulative properties of chemical compounds at the threshild level as a basis lor prognostication of chronic poisonings.! QG R PROF ZADOL 16(3): 36-53. 1972. |Engl. summ.]--Cumulative ropcrtics ol chemical compounds at the threshold of their acute action >ere analyzed. Cumulation coefficients were deduced from the integral est changes and with reference to the summary-threshold value fea- uring the functional state of the nervous system. These coefficients roved to be much inferior to coefficients of cumulation determined 'ith reference to the animal lethality figures. The cumulation coefcienis at the threshold level supported a well-marked cumulative ca- acity of benzene, carbon tetrachloride, m-aminobenzotrifluoride and lorpholine. This was supported by the data derived from chronic exeriments, considering CCI4 and benzene, also by the available clinical nd hygienic observations. The estimated coelficient ol correlation etween the areas of chronic action and coefficients of cumulation for le substances under study at the threshold level was 0.99. This makes . possible to forecast possible developments of chronic poisoning. The lvestigatlon time was cut down to a maximum of 1 mo.**J. P. K. 34773. KOBULIYA. N. S,, L. E. GEDYMIN, F. R. HERNYAKHOVSK1I and O. P. ARKHIPOVA. (Cent. Res. Inst. Tuberc., timst. Health USSR, Moscow, USSR.) Izuchenie pronitsaemosti glstoematicheskikh bar'erov pri razlichnykh rezhimakh giperbaricheskoi ksigenatsii v eksperimente. I Permeability of histo-haematlc barriers 1 different regimes of experimental hyperbaric oxygenationTT K5P HIR ANESTEZIOL 17(2): 31-33. Ulus. 1972. |Engl. Summ.) --ExenmentaUy, 70 guinea pigs were subjected to 100% O2 in therapeutic 1-2.2 up to 3 ata) and toxic (4-5 ata) regimes of hyperbaric oxygenaon for 1-4 hr. Histology and radioactive indication (with streptomyin-S35 in 20.000 U/kg and with 14.2 pCi activity in 1 ml) were used to ssess various permeability levels in the histo-hematic barriers of the ings, liver, kidneys, spleen, myocardium and brain. Toxic regimes ere accompanied by a universal increase of vascular walls pertneabily, conditioned by structural lesions of the histo-heoiatic barriers. 'ith therapeutic regimes, vascular permeability rose only in the spleen, ver and kidneys, i.e., in.the organs with an increasing functional ac- vity under hyperbaric oxygenation, and was not accompanied by histotructural changes of the main elements of the hlsto-hematlc barrier. --J. L. S. 34774. CONDER. D. W,, P. C. OLOFFS and Y. S. SZETO. (Pestot. ent., Dep. Biol. Sci., Simon Fraser Univ., Burnaby 2, B. C., Can.) LC separation of hentachlor epoxide oxychlordane. a- and y-chlordane. ULL ENVIRON CON TAM Tm&dL 33-3S.lS72.~6LC ("gas------ quid chromatography] columns were used to Identify and quantitate rganochloridc pesticide residues. Such as 3% OV 1, 2% SE 30 plus OF 1, or 2% OV 1 plus 6% OV 210. They did not satisfactorily sep- rate the compounds of o-chlordanc. y-chlordane oxychlordane and eptachlorepoxide. Gas chromatograph Micro Tck MT 220 with Nl-83 lectron cepture detector method was employed In this experiment. --J. P. K. 34775. WALTSCHEWA, W. (Forschungsinst. ArbeitsschutZ, Bendtr.. lllvd. Petko Napotov 34, Sofia, Dulg.), M. SLATEWA and f. DCllAILOiV. Ilodcnvcracnderungen bei wcissen Ratten durch chroniche Vcrabreichung von Nickelsuilat. [Testicular changes due to longrm administration of nickel sulfate in ratsVl EXP PATHOL (JENA) 13/4); flG-iiSTUlus. 1672. |Engl. summ.J--Following long-term ickel-sullate intoxication in rats, severe lesions in the germ cells artlcuLrly in spermiogencsis could be demonstrated. Very few Changs were observed in the livers and kidneys. Nickel sulfate had a ee:ctive noxious effect on testicular parenchyma. --A. B. M. "* N., ^34776.' BASALAEV, A. V.. A. N. VAZIN and A. G. KOCHETKOV. 3. M. Kirov Cork. Med. Inst,, Gorki, USSR.) K patogenezu izmenenil, oznikayuahehikh ori dUtel'nom vozdeiatvll vinilkhlorlda. [ Pathogenesle R&S 131245 3557 (Mar. 15, 1973] TQXJCGI of changes develnnlng due to long-term cynosure to the effect of vinvlchloriijp.l GIG TH i'HOF ZAllOL lfi(2): 24-27. Ilius. t972. |Engl, aumm.|--Rabbits and rain which inhaled vinylchloride fumes in a^M^ Imal permissible concentration (0.03-0.04 mg/i). underwent a 6-^^B long ail-round examination by irfiyniolngical, biochemical, histoml^^F phologlcal and roentgcnodcnsltamctrlc methods. Changes in the bio electric activity of the hypothalamus, hypcradrenalincmia and function al troubles of the cardiovascular system were disclosed. Development Of rcBorptlve manifestations in the bone tissue was brought out mor phologically and osteoporosis--roentgenologicaUy. An inference te drawn as to a key importance of hypothalamic dysfunction in the patho genesis of the disease, this dysfunction giving rise to neurohumoral and neurovascular troubles leading to the development of dystrophic pro cesses In the bone tissue.--P. L. W. 34777. BAZIN, SUZANNE and ALBERT DELAUNAY. (CNRS, Inst. Pasteur, Serv. Pathol. Exp,, 92-Garches, Fr.) Action exercee par des substances lathyrogenes sur le collagene de granulomes. (Action ex erted by lathyrogentc substances on the collagen-of granulomas.I Cft HEBD SEANCES ACAD SCI SERDSCINAt (PARIS) 274(4): 618-620. 1972.--Polyvinyl sponges were implanted s.c. in Wistar rats. Ten days later, penicillamine was given orally in a dose of 20 mg/100 g of weight. In another group, p-mercaptoethylamine was given in a dose of 0.5 mg/100 g, i.p. Cranulomatous tissue surrounding the sponges and nor mal skin were extracted to give neutral and acid soluble collagen, col lagen labile at 60 and insoluble collagen. Both drugs gave comparable results. They did not modify the total collagen of normal skin, but de creased the collagen of granulomatous tissue slightly. Neutral soluble collagen was Increased and Insoluble collagen decreased in both types of tissue. The labile collagen increased in the granuloma and dimin ished In the skin. The acid soluble collagen increased 200% in the granuloma and 30% in the skin, tntermolecular bonds in collagen which are sensitive to lathyrogens are comparable in granuloma and in nor mal skin.--M. D. S. 34778. JCUDZINA, G. D. and D. I. GOLOVAN'. (A. N. Marzeeva Kiev Res. Inst. Gen. Public Hyg., Kiev, USSR.) Sravnitel'naya otsenka gerbitsldov gruppy khlorbenzoinoi kisloty eanltarno-toksikologicfaeikim metodom i metodom kul'tur kletok. (Comparative sanitary-toxicolog ical and eell-culture evaluation of the chlorfaenzoic acid herbicide group,I VRACH DEL6 1. 125-128. Ilius. 1972. [Engl, summ.)--Data of chronic sanitary-toxicological experiment on rabbits and a study of the effect of chlorbenzoic herbicide group indicate that the resulting these 2 methods concerning the toxicity of the herbicides coincidj^^B The use of cell-culture method for rapid hygienic evaluation of tlnVK- lcity of some herbicides is promising and further investigationa of this method are Justified.--P. L. W. 34779. COOPER, PHIUP and STEPHEN H. TOUNS. (Dep. Surg., Bronx Veterans Admin. Hosp., Bronx, N. Y. 10463, USA.) Relationship between smoking history and complications immediately following sur gery tor duodenal ulcer! MT SINAI J MED i9(j): 287-292. 1972.-- No evidence is given of an association between smoking and complica tions, nor between smoking and operative mortality, nor between smok ing and days to discharge. The most obvious trend is probably predict able, namely, patients over 50 have more complications and a higher mortality rate than those under 50. In spite of the relatively large number of patients included in this report the smoking habits, the age distribution, and disease rate in the population studied are quite likely to differ from the general population. Some inconsistencies were found between smoking histones taken on the same patient at different times. This may have resulted from the quality and accuracy of the informa tion given to the examiner by the patient. Few, if any, generalities should be drawn from this research. Results apply only to immediate postoperative findings and do not apply to long-range effects of smoking upon the patient after surgery for duodenal ulcer disease.--E. M. D. 34780. LISITSA, F. M. and L. A. MOTROVA. (Fac. Postgrad. Med.. Rlfpi Med. Inst,, Riga, USSR.) O klinicheskikh osobennostyakh alkogol*nykh pollnevrttov. |Clinical traits of alcoholic polyneuritis.) ZHNEVROPATOL PSIKHlATft 1M 5"k5rsAknA 72(5): 647-651. 1972. (Engl. summ.|--The traits of alcoholic polyneuritis in 27 patients were studied. Four main clinical variants of the disease were distinguished. The most characteristic and frequent form of alcoholic polyneuritis was the syndrome of sluggish paralysis in the parts of the tower extremi ties. A more common and mixed form of polyneuritis, sensonal and atactic forms, were rarely observed.--J. P. K. 34781. STEGER, ROBERT E. (Coop. Ext. Senr., N. M. State Univ., Las Cruces, N. M., USA.) Native plants poisonous to humans. J RANGE MANAGE 25(1): 1972,--A summary is given of the toxic principles, the plants, toxic parts, symptoms and some general comments for several commonly toxic plants In the U.S.A.--D. 'S|Bk 34782. PARTS, RENE-RAYMOND and ANNE-MARIE TESSIER^Rc. Ptiarm., Lab. Matiere Med., 4-ave. Observafolre, 75-Parts 6, Fr.) Presence de substances du groups des Cucurbitaeincs chcz diverses Euphorblacees toxiques afrtcatnce, notamment chcz Maprounea membranacea Pax el K. Hofm. [Presence of substances of the group of cu- curbiiaclnes in various African toxic Euphorbiarcae especially m Ma- * taUftsUAV.AJH.. " PHARMACOLOGY (3176-3181) cVe J Cardiac Rhythm I 3176 PHARMACOLOGY OF AUTONOMIC NEUROEFFECTOR TRANSMISSION TO CELLS OF THE EMBRYONIC HEART. K. LSffclbolz* Jod Dtpzrtxmt of Fh*rmeology, University of Eicut Hexlth Crater, Farmington, CT 06032. Intneellulzr tneabrrae potentials were recorded from p*cemaker colls in the sinus venosus of chick hearts from the fifth incubation dy to the first week after hatching* Trains of Impulses (1*100 Ha) ware applied to the sinus venosus re gion of isolated atria bathed in Tyrode solution at 30"C* In hearts incubated for 11 dayi or more, stimulation for 2-5 sec caused cardiolnhlbitlon that was aceostpanled by membrane hyperpolariration and reduced action potential duration* These affects vara blocked by atropine (l0"7g/ol) and by TTX (1(H& g/ml)t but not by bexamsthonlum (lO^^g/ml)* Theta data Indi cated that acetylcholine was released from Intracsrdlac post* ganglionic cholinergic aeons by propagated action potential#. Stimulation for 2-5 esc evoked cardlosceeleration after hatching (21 dayi)* The acceleration was associated with an increased rata of slow diastolic depolarization and was blocked by propranolol (10"*g/ml), Previous studies have shown that postjunctional cholinergic and adrenergic recep tors are present by the third lncubetion day. It is conclud ed that during ontogenesis of the chick heart: 1) the post junctional receptors for the neurotransmittsrs are operative before the appearance of autonomic aeuroeffector transmis sion, and 2) adrenergic transmission develops later than does cholinergic transmission* (Supported by USPHS Grant No* HL-13339.) 3179 fMASMACOUWV TIME COURSE OF SUSCEPTIBILITY TO EPINEPHRINE-INDUCED TACHY ARRHYTHMIAS IN THE CAT FOLLOWING INHALATION OF AEROSOL PRO PELLANT. Swammel 3. Thcaoson* and Willard S. Harris*. Univ. of Illinois Med. Ctr., Chicago, Illinois 60612 (Spon: ' T. C. West). Inhalation of high concentrations of aerosol propellants, e.g., CCl^S* i* known to cause sudden death in man, some times minutes after the end of exposure, and to sensitize dogs to severe epinephrine (Epi)-induced ventricular tachy arrhythmia#. To assess the duration and disappearance rate of j^rocardial sensitization, ve injected 13 pentobarbital- anesthetized cats i.v. with L or 8 ug/kg Epi before a h min inhalation of 375 CClgF2 -21S 0% -4# Ng and periodically for 10 min after the end of the inhalation. Electrocardiograms and Intraarterial pressures were recorded*and arterial blood levels of CCloFg ve*e measured by gas chromatography. Before exposure to CCI2F2* no cats **** Epi-induced ventricular tachyarrhythmias; after CClgFg, all developed Epi-induced ventricular tachyarrhytlzoias. With 8 pg/kg Epi, 8 of 6, 7 of 8, 2 of 7* and 1 of L cats had Epi-induced ventricular tachyarrhythmias at 3, 5* 8 and 10 min post CClgFg respec tively. In summary, susceptibility to Epi-induced ventricular tachyarrhythmias persisted after the end of CGlgFg exposure, varied inversely with time as did the CClgFo blood levels, and sometimes lasted as long as 10 min postinhalation of CCljFfi- 3177 DIFFERENCES IN EFFECTS OF ANTIARRMYTHM1C AGENTS ON CELL CULTURES. R. J. Ertel, G. Ouyang? P, Gifford? F. R. Franks* end D. E- Clarke. Univ. of Pittsburgh. Sch. of Pharmacy end The Western Pennsylvania Hosp., Pittsburgh, Pa. 15213 Various concentrations of quinidJne (ft), procaineamide (PA), dlphenylhydantoin (D), Udoceioe (L), propranolol (P) and bretylium (B) were studied on cultured myocardial cells obtain ed from 7-day old chick embryos. The effects obtained on the spontaneous beating rate (SBR) and number of beating cells (NBC) in cultures derived from whole hearts are shown. SBR . NBC $PA + ** t - Increase D,L + * - decrease B.P ** * ** no change Q and PA changed the monolayer of synchronously beating cells into two distinct cell populations, ona showing an enhanced rate whereas the other exhibited a decreased rate. This phen omenon wet absent in call cultures derived solely from ventri cular cells, whereas the effects of the othee antiArrhythmic! were not qualitatively altered. Surprisingly, 6 exhibited an anti-adrenergic action which appears to occur at the level of the S-edrenotropie receptor. The experimental observations provide a cisssification of the antiarrhythmic agents which is clcssly allied to that based on electro-physiological data and clinical usage in man. This close correlation suggests thet responses of chick myocardial cell cultures are highly repre sentative of adult mammalian myocardial mechanisms. (Supported by NIH Grant No. HL-IL823). 3160 PHARMACOLOGY ACUTE AND CHRONIC ADMINISTRATION OF MORPHINE SO* EFFECT OH HEART RATE AND VENTRICULAR CONTRACTILE FORCE. A. E. Lucas*. J, Hinkebeln*. R. Klmbler* and T. D* Darby. Department of Pharmacology, University of Louisville Health Sciences Center, Louisville, Kentucky 40201. The studies were carried out in anesthetized mongrel dogs. Ventricular contractile force (1ST) was measured by the strain gauge arch technique (P.S.E.B.M. 84:263, 1953). Arterial 'blood pressure (BP) was obtained from the fesioral artery. Heart rate w*a determined from these recordings. Alterations in the cardiovascular status were produced by admlnlstratIon of cardiovascular drugs: Methoxasilite and Nitroglycerin. The response to norepinephrine was obtained* After these control procedures the animals ware challenged with 10 mg/kg of mor phine SO* IV. The alterations in cardiovascular status were repeated. Vagotomy was cospletsd and the procedure repeated. These seme studies were carried out in dogs which were treated with Increasing doses of morphine for 28 days- It was found morphine stimulates the parasympathetic reflex control (?RC) of heart rata in the acute studies, while In the chronic animals the PRC was markedly depressed, suggesting sympathetic predominance. Pretreatment with reserplne for 3 days or concomitant administration of morphine and reserplne for the lest 14 days of the 28-day morphine treatment enhanced the PRC In the acute animals snd abolished the PRC depression in the chronic aniaale. (Supported by Kentucky, Louisville and Jefferson County Heart Association Grant #64315*) 3178 Km*- - METKYLCHLOROFORM-INDUCED FIBRILLATION IN THE MOOSE. A.M. Stroaberut L.O. Johnson* and L.M. Miller*(Spon: R.K. Richards) . Dept, of Pharmacology, Inst. of Clin. Med., Syntax Research, Palo Alto, Cal. 94304 Methylchloroform-induced fibrillation in the mouse has been employed as a screening procedure for the evaluation of antiarrhythmic properties of compounds (Hermansen, Acta pharaacol. at toxicol. 78: 17, 1970). We have attempted to clarify the mechanism of this fibrillation. Adrenalectomized mice and mice pretreated with 10 mg/kg of P-286 (a compound which blocks the release of adrenal cate cholamines) were not protected against methylchloroform-induced fibrillation. Mice pretreated with reserplne (5mg/kg) and reserplne pretreated adrenalectoraiaed mice were protected. The greatest pro tection was observed following intraperitoneal pretreatment with B-blockers (e.g. propranolol, 3mg/ kg). Commonly used antiarrhythmic drugs protected only at enormous and near toxic dose levels (e.g. ocaine, SOmg/kg and guinidine, 50mg/kg). Our #ults suggest that methylchloroform-induced fiblation in the mouse cannot serve as a test for compounds effective against non-adrenergic mediated arrhythmias. However, it does appear to be a rapid and inexpensive screening procedure for detecting cardiac B-receptor blocking activity. 3181 THE EFFECTS OF ISOFRCTEErKOi. ON CARDIAC CCNDncTKW IN MAN Rsmaah Dhlncra*. Edward Winslow*. Shahbudln Rahimtoola*. Maurice Pouaet*. and Kenneth Rosen* (SPON: Lawrence Isaac). Univ. of Illinois Hospitals, Chicago, IL 60612 His bundle (H) recording: ver* obtained in 43 pstlanta (pts) during Isoproterenol (lap) infusion. Tha group constated of 5 with normal and 38 with conductlm disturbances. Tha mean a SEM A-H interval in 30 pts with normal A-H (<130 msec) was 98 a 3.1 msec prior to and 77 3.1 msec during lap. Mean A-H In 9 pts with prolonged A-H wae 192 17.1 msec prior to and 146 a 14.6 msec during lap. Tha nan H-V In 29 pts with nor mal H-V 55) was 46 a 1.0 ease prior to and 41 a 1.0 msec dur ing infusion. In 11 pts with prolonged H-V, the aten veluee were 68 a 2.7 naec prior to end 59 a 2.7 mate during lap. All these decreaees vere significant (p<-01). The foliating im provements in conduction vers noted in pte vith 2 snd 3 A-V blocks during Ip: 1) total reversal of 2 block proximal to H In 2 of 3 pts, and in 1 of 2 pts vith block dlfltsl to H, 2) development of 2:1 conduction in 1 of 3 pts with 3 A-V block end 'split' H potentials, sad 3) development of 3:1 conduction in 1 of 3 pts vith 3 A-V block distal, to H. In summary, phar macological actions of lap includs facilitation of both normal and depressed conduction in the A-V node end the His Purklnje system. CO