Document 65pGwV7yE4yg0jOxEZ8m2pnr3

October 23, 1939 nr. 8. Wilbur Bpeieher Adelnlatrator, Industrial Hygiene Veetlngjheuse Blectrle Corporation But Pittsburgh, Pennsylvania Bur Wllburt Aank you for your lottor of October 21 inquiring about the cafe use of triehlorodiphenyl and a mixture of 40* trlehlcro bonaono and 60)1 hcxaehlorodlphonyl., -- Wo marteet triehlorodiphenyl as/^Aroelor 1242"/ Tho eanblnatian of hexaehlorodiphenyl andNtOd triohloroConxeno la known aa PQ*. Tho diphonyiurtfila combination ia our 9m phyaical and chontool proportioa of tho Aroalora mentioned arc shown on tho table on pmgeo 4 and 3 of tho onoloaod Atoelcr bulletin* ftieloeed alao ia a reprint indlaatAng tho roeulta of ohronia tomlelty atudiae with AroclorsgAr and 1234. Ttvo foilouing canaonta anaiwrlng your quaatiana aerially are baaed on infovnation contained in theae bulletinc. Z believe prolonged and repeated akin eontaet with any of the Aroalora should bo avoided for two reasons, in the firct ?laee, the leea ehlerinated produeta are liquids and are axeelent solvents for oils and fata in the akin aa well as other orgenie eaterisle. Beeondly. it la poeeible that prolonged or repeated akin eontaet could load to ohloreeas* Z know or only two tweob whore aueh experience bee developed during the long history of production and use of tho Aroolora* Zn cm oeae, an Areolar woe being used so a heat transfer aadiua in a eyeten that allowed vapors to escape when the uaterlal was heated to 600}. Several workmen developed "blackheads" Milch were found by an industrial physician but which in his words wore *e in significant that aw sen were nod aware of then nor would a general praetitloner notice then* this indicates te no, however. OSW 018276 STLCOPCB4004820 JW. B. Wilbur Speioher--Page 2~0otober 23, 1959 that sufficient exposure, Aether by Inhalation of vapor* or akin contact, can result in ohloracna which I think w auat assume could be an indication of more serious systeaic injury if the exposure was allowed to continue. A second ease of mild ohloracna about which we have any knowledge resulted from workmen dipping their hands in the liquid Areolar as if it were mineral oil or vegetable oil. In addition, their clothing sooner or later became impregnated with the material and thus exposure was magnified. You asked at what temperature local exhaust ventilation should be provided. Although the distillation range for Aroelor 1242 ia 325-360C. and 385-420c. for Aroolor 1200, I feel that good practice dictates that local exhaust ventilation be provided when any of the Aroolora are heated above 1507. in open tanks or in any systems where the material is not in a completely enclosed system (vapor-proof tanks, kettles, pumps, piping, etc,), This may be ultra conservative because as the distil lation ranges and vapor pressure curves (page 12 of the Aroelor bulletin) indicate, the loss of vapors at 150P. should not be significant except in any work area where general ventilation or air changes do not exist. Your next question related again to possible skin and systemic effects and 1 believe It is answered above. In connection with the 40# trichlorobenzene-60# Aroelor 1260 combination, I believe the thoughts expressed above also apply. Z understand that the trlohlorobenzene which is used is a mixture of the l,2,3-> 1,2,4-, and l,3*5~lsoners which will begin to distill at 205C. Again, I believe this Indicates a low vapor pressure for the solvent st room temperatures, the only reference we have to triohlarobensene toxicity is con tained in the Public Health Service Publication No, 414 entitled "The Halogenated Hydrocarbons Toxicity and Potential Dangers" by Dr. w. P. von Oettingen, U.A. aovernsanb Printing Office, 1953 (pages 297-29S). Dr. von Oettingen refere to some work done in 1937 which indicated that the triehlarobenzene was less taxis than mono or dishlorobensene. In my opinion, a reasonable MAC for this material would be 100 parts per million. The enclosed publication on the toxicity of Aroolor 1242 and 1254 suggests an MAC for 1242 of 2 milligrams per cubic meter which is twice that reeossaended by the ACQIH for a chlorinated di phenyl of unstated chlorine content. In the ease of 1254, the publication suggests that the MAC of 1 milligram per cubic meter "recommended tentatively for safe industrial practice by the American Conference of Governmental Industrial Hygienists is reasonable. On the ether hand, reference te Henry Asyth's evenings Memorial Lecture of 1936 in which he diseuassd the basis for the then existing "hygienic standards" indicates that DSW 018277 STLCOPCB4004821 tfr. B. BXlbur %iahar~Pag 3~Oetober 13* 1959 Many um that MACS of 1 eg/eu.n. fw Arcelor 1249 and 0.5 ng/eu.a. far Areeler 1954 are aore realistis. la the ab sence of any ehrenie tonicity data on Arcelor I960* aa suggest an MUI of 0.5 eg/eu.n,, the aano aa In the aaaa of 1254* X hove baan In oaa plant where thaaa aatarlala vara used for capacitors and transformers. The earn and handling and the provision* of exhaust ventilation vara not in aaaordanaa with the thoughts expressed above. The only reported difficulty was scbm slid eye irritation ebon Impregnation cabinets whore the ltana vara heated te 110-1*0C. released vapors of trlahlarebensene end the Areolar into the workman when the cabinet dears ware npanad* Xn ay adnd* sush aabinets should be ventilated to rinrriB the vapara rather than allow than te be released into the i told that your eonpeny has had sons 20-25 years' with the produota diaeuaaed abeve. It was suggestad B. ferd* eanager of transfomsr aanufaaturlng at your Sharon riant would bo a scums of inform- experianae with Xnartaen PPO. Similarly* Mr. Wupbury ef your Blooningtcn* Indiana flant has baan ated with the use ef Aroelor 1249. perhaps you have aldiaeussed potential exposures with these gentlemen. If Interested in learning ef their preetleal exwlth these preduets. X lasts you in Pittsburgh next Binoerely* P idteelsr Assistant Director OSW 018278 STLCOPCB4004822