Document 60XJjm8mMKj7ed59x1zx2aMR

AR226-1397 a em Er E. I. ou PonT bE NEMOURS & CoMPANY CENTRAWLILREMSIENAGRTCOHN.&DEDVEELLAOWPMAERNET 1D9E6P5A8RTMENT TOXICOLEZY AND INDUSTRIAL MEDICINE bec: 3C..FW.l RRaeiinnehsard-t/PsP.D C-. M-M5c6K2u3sick S. 6. Hundley/R. W. Hartgrove H. J. Trochimowicz/J. G. Aftosmis I-43 ARRR6 -- 139 7 March 16, 1982 1Dr5.79J2oseph Seifter OUf.fSi.ceEonfviTrooxnimcentSaulbstParnocteesction Agency W4a0s1hiMn"gtoSnt,reeDt.,C. S.W2.0460 Dear Dr. Seifter:' A ochcetmainccWaaeltehoanv(eCG-8es)sttuaditinieodtnhetDhaeaylbpil1n9aoceannrtdaatlfboyltlrooawrniasnlfgleyrmaaotfdemrilnn4aicls-tpeberlriofnolgduoratonh-de 1 acffreteteaalrseddtoisbsiesntugwe.eelneMvae2tlesarnondafl4tbhholeuororsdadaitonhcedanrpbldoaenccerneatatasle2,dlbe4,evtewlaesnednof84h1o4auCnrdsin- haopuprrsoxiamfatteerlydos1i2,ng.20 Tahned 1u2g egq/umilvalaetnt2s, i4,n dosing, respectively. Corresponding fetal maantder8nahlourbsloopdostweere levels (whole body 2gsays) were 0.7, 3, and 3 ug/ml. These data demonstrate that lic-labelled C-8 does transfer across the placenta of the rat. questiPolnesa.se call me (302-366-5259) if you have any further sincerely, GLK: seg Al, Katy GSeercatlidonL.SupKeernvniesdoyr,, fr. Acute Investigations BETTER THINGS FOR BETTER LIVING.... THROUGH CHEMISTRY EIDO71704 : oouOIgE