Document 5kkvZGy2ZVommo0rXee4RL778

AR226-2023 INTEROFFICE MEMORANDUM Data: Fronis Dept; T&l NO; 12-Oeo-1S96 02;30pm EPT ANTHONY J. [TONY] PLAYTIS PLAYTIS POLYMERS SHE&EA 304-863-2228 TO: ROBERT R. MATTSOM TO; YOUN6ER L. POWER, M.D. CC; Gregory A Chapman CO; BARRY L HUDSON CC: William J Vogler ( MATTSORR ) ( POHERYL ) ( CHAPMA6A ) ( HUOSONBL ) ( V08LERHJ AT A1 AT H8KVAX ) Subject: RE; O.H. Review -OpgaftofluopiRfr Compounds Ramirez and Reinhardt Bake a number of recommendations concerning medical surveillance for several biopwsisten-t fluorocheaical^, specifically.C-8 at Washington Works and TAP and HFPO trimer at Fayetteville Works. In this letter, I. list each recommendation- (CAPITAL LETTERS) a-long^ Mi-th what I believe is the appropriate action for this site. I tried to take into account the considerations that were raiseA in- our earlier discussion and also what I learned from talking to Gerry Kennedy, 1) CONTINUE, BUT ENHANCE PRIMARY PREVENTION THROUGH USE OF ENGINEERING CONTROLS AND UTILIZATION OF PERSONAL PROTECTIVE EQUIPMENT. The- site is already com^tted- to this course wf- action. One of the action points from my May 1996 summary of the 1995 blood! study results was to do j-ob reviews-and employee interviews, in ocdep to idatttify rout&s of C"8 exposure that may be better controlled. This analysis has recently been completed, and the peeulta will be Used by the &TO- in- its ongoing, efforts to improve C-8 handling. In fact, the job reviews showed a number of instances where the BTO proaetiv&ly installed englneepin^ e&n-tpols- that- seould reduce the potential for c-8 exposure. 2) EXPOSURE POTENTIAL AND. PROGRAM- EFFECTIVENESS.. SHOULD- BE MONITORED. BY BOTH AIR SAMPLING. AND BIOMONITORIN6. Me- alF&ady do this, with- rou-tine" induatpia-l- hygiene, a-ir monitoring, and Mith our 5-year blood testing. 3) SKIM. EXPOSURE POTENTIAL SHOULD- BE. ADDRESSED-. BY APPROPRIATE WIRE- SAMPLIN8 AND BIOHONITORIN8. Me- a-lpeady do the biomonj.twing, but wipfr- sampling has been limited to it If special studies, such as the one to determine the G-8 exposure from PEP dust. Additional wipe sampling would, be a. reasonable thing for u to do. any problem areas are identified, we should make a part of our routine monitoring, .....RECOMMEND PRE.ASSIGNMENT AND POST-ASSIGNMENT EXAMINATIONS BE CONDUCTED. WE ALSO RECOMMEND THAT BASELINE EXAMINATIONS BE CONDUCTED ON ALL CURRENT EMPLOYEES MHO HAVE NOT PAffFI&IPATE& IM PREVIOUS- SURVEILLANCE CAMPAIGNS. T^ESE EXAMINATIONS ARE TO INCLUDE: 1) MEDICAL HISTORY QUESTIONNAIRE INCLUDING! 8MOKIN8 HISTORY. 2) BLOOD TESTS - COMPLETE BLOOD COUNT - SMA-12 - FLUORINE-^-BLOOD-TEST. EID924123 There are two separate issues here. First, should Me force employees to be tested. Second, are the- reeetmeBtted tests- appropriate-. Voluntary participation in the 1895 blood study Mas about 50% of the employees who were contacted. Ttw only way to- get t(Wfe participation from the C-8-exposed cohort Mould be to force these people to submit to invasive medical if testing, This Mill create- employee relations issuer, and Me have to ask ourselves it is worthwhile to do so. Considering the lack of evidenoe of a 0-8 health problem, and the amount of. additional infopaiatioft to be gained,, and the low level of employee concern, I think the answer is no. This brings us to the question- ef the- usefulness- of the proposed tesjts, nhich seem more appropriate for the chemicals of concern at Fayetteville. In tha case of C-a, the target organs- are-Bot really known. The data from rodent studies are not applicable to humans, and all epideniologio Mork thus far, including- liver function studies, has-not shown-any eenfl^Otion between chronic C-8 exposure and human disease. I would recommend that we postpone any additional medical surveillance until the- cottple-tion- of the. planned rhe,su8 if monkey toxicology study. This study, using a more appropriate primate test speeiea-, should give us a nuefr better idea- of what, anything, to Monitor in humans. WE ALS& BECOMll& THAT PERMANENT- BOSTEBS.. BE. ESTABLISHED- FOB ORGANOFLUORINE COHORTS. THE FOLLOMIN6 INFORMATION SHOULD BE MAINTAINED FOR EACH COHORT MEMBEH; t) DEMOGRAPHIC IMFORWffEW -SeCTAt SECURITY MUMSEft, &1HTHDATE, $EX, ASD. 2) MOHK HISTORY INFORMATION - JOB TITLE, WORK AREA, ENTRANCE AND EXIT DATE& a). EXPOSURE HISTORY-IMDBttOUALAJOS/OROUP - AIB. MONITORIM DATA, BIOMONITORINQ DATA, MIPE SAWLIMQ OATA. We already do this at Washington Morks with- the-help^ at two computer programs, FLAIR and HYGIENE. WE RECOMMEH& THAT EACH iNCIDEttt OR EXPOSURE TO-ORaAMOFLllORItlE. COMPOUND?BE ADDRESSED ON A CASE BY CASE BASIS BY A QUALIFIED PEDICAL PROFESSIONAL. Bp. Power, the Plant Mecl-ieat SKpapiB-tendeBt-, routinely reviews each serious safety incident that involves an overexposure to a chemical agent, WE RECOMMEND THAT MONITORING- CONTINUE-TO-ENSURE-EXPOSUBEa ARE KEPT BELOW THE AEL. PERIODIC APPRAISALS OF THE DATA SHOULD BE GONE TO GUIDE FUTURE OCCUPATIONAL HEALTH EFFORTS CONeERNTOQ BRBANOFtUOfHNE WORKERS. - This is done as part of our routine industrial hygiene monitoring. PARTNERSHIP AMD EXCHANGE Ol? INFORtWaoH-MITO 3M- OB- OIHEB. MANUFACTURERS SHOULD BE CONTINUED. In the case of C-8, this is>-dar>fr at- the-SBU-lev&l and by Has^ell Laboratory. CONSIDERATION SHOULD BE 6I.VEN- TO UNDERTAKE- A STUDY. TO DETERMINE THE BLOpD ELIMINATION RATE OF OR6ANOFLUORINE COMPOUNDS.....REVIEW OF WASHINGTON WORKS EMPLOYEES- BLOOD RESULTS SueaESTS THAT A 1-ARQE ENSUflH-PaOL OP RETIRED OR TRANSFERRED ORQANOFLUORINE WORKERS IS NOW AVAILABLE FOR TESTING. This was. already done as- pact ot. war 1895- blood-study. The pool of test subjects is not large enough to be useful for two reasons. First, an initial C-& blaod- test must be run- vepy- elose- to- the-time-tha-t exposure- stops. This was the case for very few retirees. Second,..the limited data we do have EID924124 indicates there is a wide variablility in the rate of C-8 elimination, necessitating a. large grou(x of teat sub.] acts- ta gat. a- good average result.. It is unknown whether this variability is associated with individual metabolism, initial C-8 blood level, or test error. EID924125