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ronnie once omaiii wes #R226 _ 1162 TAFT, STETTINIUS & HOLLISTER LLP aoggmonacme 425 WALNUT STREET, SUITE 1800 CINCINNATI, OHIO 45202-3957 Fasx 51m3.38n1.0205 cunnyesisenasgon ond Fait Soups AusS0i0 i wwwtaflaw com aE RSo8os1er3rg6A7e..nB0i8cL%oormT August 26, 2002 = CERTIFIED MAIL NO. 7002 0860 0006 6119 4910 RETURN RECEIPT REQUESTED IclRoISASSuRbCmission Desk 6301 Ivy Lane, Suite 300 Greenbelt, MD 20770 = 33 a 32 Eza 3% 5= Re: IRIS Sa ubmiss sion IN nventoo ry ford Perflg uoroocp tandics Acid-2Amm6 oniuy m Salt IRIS Submission Desk: On April 12. 2002, we submitted information to you in connection with the referenced IRIS Submission Inventory, pursuant to a January 9, 2002 notice in the Federal Register (627 Fed. Reg. 1214 referencing the (Jan. 9, 2002). We following additional are hereby supplementing our April information relating to the chemical 12, 2002. submission at issue. copies of by which are available from our files: 1 KOexllyegr,eY-namDaepneankdaa,natnHdepTahtuortmoaxnic,it"yInBhiybiStiixonSotrfuMctiutroaclhloyndDirsisailmiRleasrpiPreartoixoinsaonmdal Proliferating Agents." Toxicology 49-61 (1992); 2 Keller, Marsman, et al. "Several Non-Genotoxic Carcinogens Uncouple Mitochondrial Oxidative Phosphorylation," 1102 Biochemica et Biophysia Acta. 237-44 (1992); 3. Panaretakis, Shabalina, et al. "Reactive Oxygen Species and Mitochondria MReoddieanttePtehreoIxnidsuocmteiPornoolfifAepraotpotroasinsd iHneHpautmoacanrcHienpoagteon.maPeHfelupoGr2ooCcetlalnsoibcyAtchied." 173 Toxicology and Applied Pharmacology 56-64 (2001); 000040 4. NB-eErthhiyaluPmeerfalnudorWoaolcltaacnee,s"uPlefrofrlaumoirdooocEttahnaonaotle:, PPeerrfolxuiosroomoectParnoelsiuflefroantaitoen.aanndd Mitochondrial Biogenesis." 129 Toxicology Letters 23-32 (2002); 5. SMtiatrokcohvonadnrdiaWlalDlyascfeu,nct"iSotnru.c"tu6r6alTDoextiecrolmoigniacnatlsoSfciFelnucoesro2c4h4e-m2i5c2al(-2I0n0d2)u:ced 6. OFxosisdlaiteinv,e"PRheovsipehwo:ryMliattoicohno.n"d3r1iatlrMaedsiocfiCnl-einMo&lecLaubl.arScPiaetnhcoelsog3y5o-f6D7e(f2e0c0t1i)v:e 7. PWhaalrlmaocceoaln.dSTtoxairckolo.v"3M5i3t-o3c8ho(n2d0r0i0a)l; Targets of Drug Toxicity." 40 Annu. Rev. 8. 2Wa0l0l2acSeO,T"MPorleesecnutlaatrioMne):chaanndisms of Perfluorooctanesulfonate Toxicity," (March 9. APsusrdeys,s "RPisekr.f"lu(rNooavl.ky2l00A1nioSnEs:TATChePrCeassenetaftoironA)g.gregation to Develop SARs and RABirt ce: LR.arrEydAis.onWiHniltle.r,EsEqs.q JGeenrniafledrJ.SReaepdie(nU.SEEsPqA) ol ve Ver yous, | Robert ABfon + 000041