Document 5kJmdqeqv1o6aLnBRZ8Qjw7xV

JLeetl laidhacslrfes A2ssMaSolS]ra,Iiia, a3MADI*ONAV(NUI *: >' mew TOUK. x, Y. 100IT * MU COM (I* I July 0^, 1966 ,! ! i P*naylv*al* St*to Air PollutLoo Control Comlscloo e/o Dep*rto*nt Of Health Division of Air Pollution Control Poet Offloe Box 90 Hsrricburt, P>. 17101 Geotleaeaj 2 V* have boos *4vl**d that your CcanUtloo 1* cca- J i Herts* the drafting of *lr <p-*llty enter!*, locludln^. i*e for lead. Vo would, therefore, Ilk* to Infora yen of r -'Ch prograns which the lead industry h** under v*y and utile, -i concerned with lev Ict-el exposure* of tie kind likely t. -ur la the cahleat atneephere and which *re declined to pror-- scientific answer* to queetloc* likely to *rl* vtven criteria or* being let*rained. About four yr*r age sensor* of the 1**4 ind-i.ry *td the U.3. Public Health Service agreed tfctt It would o t* tc -etlgs * project, or project*, which would le*d to *a**-.-* to the quonico ** to vh*t effect low level exposure to 1**4 vouU. b*v# eo the husxa syttca and to attempt to ^uaatltat* *uch expoeurt* In tern* of cooeestratlca of 1**4 la lr. The Kettering Laboratory *t up *0 experlaratal protocol tC*. would ue bucan volunteer* la exposure charter* and expo*# the * volunteer* to low level, and incre**irg aaCuat* Of le*4 la air. 1 The level* of lead satatalsed la the** Inhalation chasbere would be progre**lv#ly Increased la *ult*ble Increcent* of <tc eatret loo *od tine. S' la order to te*t whether or not *ucb *a e~. rlneat would give igntflcant recult*, the first pfc**e attempted to **ure th* effect of eootUuOu* exposure *t 150 alcroen-a* per .lOU neter of *lr. You will nraenber tht 150 aicro^nu* per ..Ale **ter of *ir was the 0*4 industrial hygiene expo*..-* Halt for sight boure * 4*7. Thl* pfc**e of the experlaeat v** ecapiet*4 and shoved that when huswao beta** are exposed continuously ;o .>0 nlcrogreg** per cubic a*ter of 1**4 la *1r, la o*whai *V!"* *11* 1 .5 '3 2 S j . Pennsylvania State Air Pollution Control Coocissloo over tvo year* blood lead level* would reach 80 sicrogra&s per coat, which 1* the Halt prescribed by Dr. Kehoe below which clinical cAalfestatlcns ere not found. The cost important res*on for performing this first phe.se vu to test the method sod to determine whether It could provide slgniTlcaat result* wihout necessity of coo!Islr-g * human subject In an exposure chamber for 2b hour* * day. Here Is s brief outline of the experimental method thst vu used: First so exposure of two hours e dsy until squlllbrlua value* of lead In blood were reached, then four hours s day until equilibrium values of lead In blood were reached, then eight hours a day and finally sixteen hours a day. Using these equilibrium blood values as points ca sn exposure curve it vs possible to ex trapolate the curve to the point of twenty fo-r hours a day. Tala satisfied us that the use of lncrenental tines gave significant results, result* vhlch coincide with those obtained In ether human exposure studies. Each of these experiments requires at least one year to ccaplete and we are now la o-r third year of operating this study. Ve now have tvo sea being exposed la Inhalation chAnoers and plan to continue the study util significant sad reproducible results have beea obtained. Financial support for these studies, sa veil as several other Inhalation casnoer stucica using rats as confirmation. Is proviusd by 'he Ic-.i tn-uvl.-y, 'T.-.c ;.--.-lcsa tvtroleua latHi-h and the United States Public Health Service. The State Health Deport* sent In California has agreed with us that these are valuable experiment* and that the results will be of great Interest to them when they are ready to detemlae air quality criteria for lead. Ve, therefore, suggest to your Ccrxxlsslon, that the results of these experiments will be of equal value Vo you la the determination of rational and scientific air quality criteria. This study 1* being performed la the public Interest and the results will be node taeva to all interested parties. Thus far sufficient dAt* has sot been acc-tulated to provide a sv_-.ber, or nush.rs, vnst would be of scientific signifi cance. Ve have assured that sir quality criteria far tshio mate rials should be derived free, data thst is stgnlf leant la terns of hw-An health. Our stulies ere unique is the field if lr pollution, si's of co.rse exceedingly expansive la le;~.e of dollars, but, wn*t is neat important, give u results that hrsotly relate to human physiology, results that do not have to S# satrap* olated frua one animal species to another. i VBA. Of.' r 't'Sivv, . *. ies.m.1 v.g J-- mjia >sr.. ws e : '* -fasttE,-' -- r Page Three Pennsylvania State Air Pollution Control Cosclssioo s The lead industry hai in the past, and vill continue in the future, to act in a recpcnsiole rurstr and vill cooperate vlth all interested Government and private agencies in evaluation of lend and tnc pun lie health. Our iniustry and its members have spent r~..y millions of dollars on the evaluation of the relationship of lead to problems of health: therefore, ve believe ve are in a position to ask your cooperation, end to cooperate vlth you in the establishment of scientific and reasonable air quality standards. In our opinion one cf the most important activities of Government areno lea in the field of air conservation and pollution control it toe establishment of reasonable air quality criteria. Che report of the Research K&nagesest Advisory Panel to the Committee ca Science and Aatrccautlcs cf the U. S. House cf Representatives, which is entitled "Che Adequacy of Cechrolopy for Pollution Abatement*, nausea the following statement vnich is pertinent to our discussion here: ; ! r f i; f i ; ; : !.- f Oace the seals of pollution abatement are f' agreed on, attention can be directed to the equally important questions of how the goals can be attained ' cost effectively, end who tnould pay the costs of ; measures to bring about the desired conditions, 1 i | Che panel believes that science and technology ! trust play an important role in finding answers to ail of these questions. CUv'-e nnat are cat in hamcr.y vitn the e -; - < 'i u.-. deriving t-.e fieud t a j never to attained. Very truly yours. I*oo 0. fowler i ECfiJb cj Hr. Allan D- randt Kr. Victor H. gussaan i5 9 d S 1'